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Enantioselective trapping of phosphoramidate ammonium ylides with imino esters for synthesis of 2,3-diaminosuccinic acid derivatives.
- Source :
-
Chemical Communications . 2013, Vol. 49 Issue 39, p4238-4240. 3p. - Publication Year :
- 2013
-
Abstract
- A highly enantioselective trapping of protic phosphoramidate ammonium ylides with α-imino esters is reported. The intriguing Rh2(OAc)4 and chiral Brønsted acid co-catalyzed three-component Mannich-type reaction of a diazo compound, a phosphoramidate, and an α-imino ester provides a rapid and efficient access to 2,3-diaminosuccinic acid derivatives with a high level control of diastereo- and enantioselectivity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENANTIOSELECTIVE catalysis
*AMINE ylides
*ALKOXY compounds
*ESTERS
*SUCCINIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 49
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 100864985
- Full Text :
- https://doi.org/10.1039/c3cc36972b