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Five new phenolic compounds from Dendrobium aphyllum.
- Source :
-
Fitoterapia . Jan2015, Vol. 100, p11-18. 8p. - Publication Year :
- 2015
-
Abstract
- One new phenanthrene, aphyllone A ( 1 ) and four new bibenzyl derivatives, aphyllone B ( 2 ) and aphyllals C–D ( 3 – 5 ), together with nine known compounds ( 6–14 ), were isolated from the stems of Dendrobium aphyllum (Roxb.) C. E. Fischer. The structures of these new compounds were elucidated by means of extensive spectroscopic analyses, and the absolute configuration of compound 1 was determined by single crystal X-ray diffraction and quantum calculations. Compounds 6 , 8 and 14 inhibited NO production at the concentration of 25 μM in LPS-stimulated RAW264.7 cells with the inhibition (%) of 32.48, 35.68, and 38.50. Compound 2 possessed significant DPPH radical scavenging activity with scavenging percentage of 87.97% at the concentration of 100 μg/mL. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHENOL analysis
*ALTERNATIVE medicine
*ANIMAL experimentation
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*DOSE-effect relationship in pharmacology
*FREE radicals
*MEDICINAL plants
*MICE
*NITRIC oxide
*SPECTRUM analysis
*PLANT stems
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 100
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 100682289
- Full Text :
- https://doi.org/10.1016/j.fitote.2014.11.004