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MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation
- Source :
-
FEBS Letters . Jul2003, Vol. 546 Issue 1, p51. 8p. - Publication Year :
- 2003
-
Abstract
- That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation. [Copyright &y& Elsevier]
- Subjects :
- *PROTEIN kinases
*PHOSPHORYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 546
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 10062629
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00451-4