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Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes.
- Source :
-
British Journal of Haematology . Feb2015, Vol. 168 Issue 3, p361-370. 10p. 3 Charts, 3 Graphs. - Publication Year :
- 2015
-
Abstract
- The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes ( MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life ( Qo L) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy ( FACIT)- Fatigue scale and Qo L was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire- Core 30 ( EORTC QLQ- C30). Female gender ( P = 0·018), poor performance status (i.e., ECOG of 2-4) ( P < 0·001) and lower levels of haemoglobin ( Hb) ( P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global Qo L scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation ( SD), 18·3] and 69·0 ( SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall Qo L more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 168
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 100548685
- Full Text :
- https://doi.org/10.1111/bjh.13138