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The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2014, Vol. 2014, p1-7. 7p. 5 Graphs. - Publication Year :
- 2014
-
Abstract
- This study is undertaken to evaluate cognitive enhancing effect and neuroprotective effect of Loranthus parasiticus. Cognitive enhancing effect of Loranthus parasiticus was investigated on scopolamine-induced amnesia model in Morris water maze test and passive avoidance test. We also examined the neuroprotective effect on glutamate-induced cell death in HT22 cells by MTT assay. These results of Morris water maze test and passive avoidance test indicated that 10 and 50mg/kg of Loranthus parasiticus reversed scopolamine-induced memory deficits. Loranthus parasiticus also protected against glutamate-induced cytotoxicity in HT22 cells. As a result of in vitro test for elucidating possible mechanism, Loranthus parasiticus inhibited AChE activity, ROS production, and Ca2+ accumulation. Loranthus parasiticus showed memory enhancing effect and neuroprotective effect and these effects may be related to inhibition of AChE activity, ROS level, and Ca2+ influx. [ABSTRACT FROM AUTHOR]
- Subjects :
- *REACTIVE oxygen species
*ANALYSIS of variance
*ANIMAL experimentation
*APOPTOSIS
*CELL culture
*MEDICINAL plants
*MEMORY
*MEMORY disorders
*MICE
*ORAL drug administration
*RESEARCH funding
*SCOPOLAMINE
*STATISTICS
*TOXICITY testing
*PHYTOCHEMICALS
*PLANT extracts
*DATA analysis
*IN vitro studies
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2014
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 100528111
- Full Text :
- https://doi.org/10.1155/2014/860180