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Effects of switching from oral administration to intravenous injection of l-carnitine on lipid metabolism in hemodialysis patients.
- Source :
-
Clinical Kidney Journal . Oct2014, Vol. 7 Issue 5, p470-474. 5p. - Publication Year :
- 2014
-
Abstract
- Background Carnitine deficiency may contribute to cardiovascular disease (CVD) in patients with hemodialysis (HD). Dyslipidemia plays a role in CVD and its prevalence is also high in HD patients. We examined here the effects of switching from oral administration (PO) to intravenous (IV) injection of l-carnitine on lipid metabolism in patients with HD. Methods Nine HD patients who had received l-carnitine orally (900 mg/day) for 1 year were enrolled in this study. We examined whether lipid parameters were improved by switching to IV injection therapy of 1000 mg l-carnitine. Results IV injection of l-carnitine for 1 week significantly increased total, free and acyl carnitine levels both before and after HD. Switching to IV injection therapy for 1 and 4 weeks decreased serum free fatty acid (FFA) (322 ± 104 versus 261 ± 124 µmol/L) and increased high-density lipoprotein-cholesterol levels (1.46 ± 0.49 versus 1.63 ± 0.62 mmol/L), respectively. Change in FFA values from the baseline (ΔFFA) was positively correlated with the Δacyl/free carnitine ratio (r2 = 0.553, P = 0.022). Conclusion This study demonstrated that switching to IV l-carnitine therapy from oral supplementation improved lipid profiles, thus supporting the clinical utility of IV administration of l-carnitine for the treatment of patients on HD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20488505
- Volume :
- 7
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Clinical Kidney Journal
- Publication Type :
- Academic Journal
- Accession number :
- 100383772
- Full Text :
- https://doi.org/10.1093/ckj/sfu082