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Chinese Herbal Medicine for Obesity: A Randomized, Double-Blinded, Multicenter, Prospective Trial.
- Source :
-
American Journal of Chinese Medicine . 2014, Vol. 42 Issue 6, p1345-1356. 12p. 1 Diagram, 2 Charts, 3 Graphs. - Publication Year :
- 2014
-
Abstract
- Obesity is a serious medical problem worldwide. As a holistic therapy, traditional Chinese medicine (TCM) may have a potential in obesity management. In this controlled trial, we evaluated the safety and effectiveness of Xin-Ju-Xiao-Gao-Fang (XJXGF), a TCM herbal formulation, in 140 obese subjects over a 24-week period. The XJXGF formula mainly consists of rhubarb, coptis, semen cassia, and citrus aurantium. Subjects with body mass index (BMI) 28-40 kg/m2 were recruited at 5 centers in China. We assessed the changes in subjects' body weight, its related parameters, and the reduction of insulin resistance (IR) after administration of XJXGF formula or low-dose XJXGF (10% of the XJXGF formula, as control). After 24-week treatment, among participants in the XJXGF formula group and low-dose XJXGF group, the mean ± SE changes in the body weight were -3.58 ± 0.48 and -1.91 ± 0.38 kg, respectively (p < 0.01). The changes in the IR-index of two groups were -2.65 ± 1.04 and -1.58 ± 1.3, respectively (p < 0 .05). There were no serious adverse events reported during the 24-week trial. Participants reported 7 minor adverse events, 4 in the XJXGF formula group and 3 in the low-dose XJXGF group (p = 0.578). Future studies are needed to investigate the clinical utility of this TCM formulation in the treatment of obese subjects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY treatment
*BODY weight
*CONFIDENCE intervals
*HIGH performance liquid chromatography
*LONGITUDINAL method
*CHINESE medicine
*RESEARCH funding
*STATISTICAL sampling
*STATISTICS
*T-test (Statistics)
*DATA analysis
*RANDOMIZED controlled trials
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
*MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 0192415X
- Volume :
- 42
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 100160165
- Full Text :
- https://doi.org/10.1142/S0192415X14500840