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In or out? On the tightness of glycosomal compartmentalization of metabolites and enzymes in Trypanosoma brucei.

Authors :
Haanstra, Jurgen R.
Bakker, Barbara M.
Michels, Paul A.M.
Source :
Molecular & Biochemical Parasitology. Nov2014, Vol. 198 Issue 1, p18-28. 11p.
Publication Year :
2014

Abstract

Trypanosomatids sequester large parts of glucose metabolism inside specialised peroxisomes, called glycosomes. Many studies have shown that correct glycosomal compartmentalization of glycolytic enzymes is essential for bloodstream-form Trypanosoma brucei . The recent finding of pore-forming activities in glycosomal membrane preparations and extensions of the trypanosome glycolysis computer model with size-selective pores sparked again an old debate on the extent of (im)permeability of the glycosomal membrane and whether glycosomally located glycolytic enzymes could and should also be present with some activity in the cytosol. This review presents a critical discussion of the experimental and theoretical evidence for and against the different hypotheses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01666851
Volume :
198
Issue :
1
Database :
Academic Search Index
Journal :
Molecular & Biochemical Parasitology
Publication Type :
Academic Journal
Accession number :
100153336
Full Text :
https://doi.org/10.1016/j.molbiopara.2014.11.004