73,787 results on '"*ELECTRIC impedance"'
Search Results
2. Phase angle differences between injured and uninjured athletes: A cross-sectional study
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Sganzerla, Gianfranco, Gobbo, Luis Alberto, Mendonça, André Luiz Bisel, Ravagnani, Fabricio Cesar de Paula, Oliveira-Junior, Silvio Assis de, Cordeiro, Vitor, and Coelho-Ravagnani, Christianne F.
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- 2025
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3. Local epicardial robotic-enhanced hybrid ablation efficacy predictors for persistent atrial fibrillation
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Celentano, Eduardo, Cristiano, Ernesto, Schena, Stefano, Gasparri, Mario, Ignatiuk, Barbara, Renda, Martina, Bia, Elena, Rainone, Raffaele, Graniero, Ascanio, Giroletti, Laura, Agnino, Alfonso, and De Groot, Natasja M.S.
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- 2024
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4. Phase Angle and Body Composition as Predictors of Fitness and Athletic Performance in Adolescent Boxers.
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Ayala-Guzmán, César Iván, Ortiz-Hernandez, Luis, Escudero Malpica, Cristian, Macias Rosas, Alejandro, and Castro Avila, Jesus Ivan
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BOXING ,CARDIOPULMONARY fitness ,BODY composition ,BIOELECTRIC impedance ,PHYSICAL fitness ,ATHLETIC ability ,ANTHROPOMETRY ,NUTRITION ,REGRESSION analysis ,ADOLESCENCE - Abstract
Background: Phase angle (PhA) is an indicator of cellular health, function, and integrity. PhA has been considered an indicator of nutritional and health status, but it is uncertain whether it could be used as a fitness or athletic performance indicator. Objective: To analyze the relationship between PhA and the fitness and athletic performance of adolescent boxers and to know whether this association is independent of body composition. Methods: Thirty-seven trained youth boxers (15–18 y old) participated in the study. Participants underwent anthropometry and bioelectrical impedance assessments. The following tests were conducted: Fitness-Gram battery; speed, agility, and quickness; ball throws; punch impact force; bench press maximal strength; and vertical and horizontal jumps. Linear regression models were estimated and adjusted by covariates. Results: The PhA was related to upper-limb strength. Nevertheless, in linear regression models, after adjusting models by body composition, only PhA remained as a predictor of relative maximal strength. The PhA was not a predictor of speed, agility, and quickness; cardiorespiratory fitness; or lower-limb power, in which adiposity was the main predictor of fitness. Conclusions: In adolescent boxers, PhA can predict upper-limb maximal strength independently of bioelectrical impedance analysis premises. However, compared with mucle mass, PhA is not a better predictor of upper-limb maximal strength. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Anomalous power-law behavior in the electrical impedance of endothelial cellular networks.
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Galpayage Dona, Kalpani N. U., Du, E., and Lau, A. W. C.
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ELECTRIC impedance , *BIOMATERIALS , *PERCOLATION , *INFLAMMATION , *EXPONENTS - Abstract
In this paper, we report on the electrical impedance measurement of human endothelial cellular networks and show the existence of emergent power law behavior in its admittance. In particular, we find that the admittance scales with the frequency ω as ωα, with the exponent that varies with the degree of the disruption caused by the inflammation in the endothelial cellular network. We demonstrate that the power law of the measured electrical admittance can be understood by a simple percolation model of a large R–C (resistor–capacitor) network, which allows us to relate quantitatively and the intensity of inflammation. Our results suggest that the electrical properties of heterogeneous biomaterials, like living tissues, behave as a complex microstructural network. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Non-Invasive Detection of Early-Stage Fatty Liver Disease via an On-Skin Impedance Sensor and Attention-Based Deep Learning.
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Wang, Kaidong, Margolis, Samuel, Cho, Jae, Wang, Shaolei, Arianpour, Brian, Jabalera, Alejandro, Yin, Junyi, Hong, Wen, Zhang, Yaran, Zhao, Peng, Zhu, Enbo, Reddy, Srinivasa, and Hsiai, Tzung
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attention mechanism ,deep learning ,electrical impedance ,nonalcoholic fatty liver disease ,on‐skin sensor ,Deep Learning ,Animals ,Non-alcoholic Fatty Liver Disease ,Mice ,Electric Impedance ,Disease Models ,Animal ,Early Diagnosis ,Mice ,Knockout ,Humans - Abstract
Early-stage nonalcoholic fatty liver disease (NAFLD) is a silent condition, with most cases going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non-invasive and cost-effective detection method for early-stage NAFLD detection is a public health priority but challenging. In this study, an adhesive, soft on-skin sensor with low electrode-skin contact impedance for early-stage NAFLD detection is fabricated. A method is developed to synthesize platinum nanoparticles and reduced graphene quantum dots onto the on-skin sensor to reduce electrode-skin contact impedance by increasing double-layer capacitance, thereby enhancing detection accuracy. Furthermore, an attention-based deep learning algorithm is introduced to differentiate impedance signals associated with early-stage NAFLD in high-fat-diet-fed low-density lipoprotein receptor knockout (Ldlr-/-) mice compared to healthy controls. The integration of an adhesive, soft on-skin sensor with low electrode-skin contact impedance and the attention-based deep learning algorithm significantly enhances the detection accuracy for early-stage NAFLD, achieving a rate above 97.5% with an area under the receiver operating characteristic curve (AUC) of 1.0. The findings present a non-invasive approach for early-stage NAFLD detection and display a strategy for improved early detection through on-skin electronics and deep learning.
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- 2024
7. FPGA implementation of a non-invasive prognostic system for classification of risk in dengue haemorrhagic fever.
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Devarasu, Neelamegam and Panneerselvam, Bhuvaneswari
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DENGUE hemorrhagic fever , *BIOELECTRIC impedance , *PLATELET count , *ASPARTATE aminotransferase , *DENGUE , *ALANINE aminotransferase - Abstract
A noninvasive investigation on 44 hospitalized Dengue Hemorrhagic Fever (DHF) subjects, male and female, aged 3 to 14, underwent a noninvasive study to determine the severity of dengue using bioelectrical impedance analysis. (BIA). Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Haematocrit (HCT), Platelet (PLT), and Alanine aminotransferase (ALT) levels were taken for classification of risk under low risk and high-risk DHF in 30 of the 44 subjects who were confirmed to be NS1 positive at the time of admission. It is discovered that the ratio of fluid volumes, hematocrit, and platelet count exhibit a linear association with measured bioelectrical impedance, conductivity, and phase angle on the body. A dual frequency method is suggested to determine the ratio of ECF/ICF, HCT, and PLT to provide a better and more accurate estimate of the hematological profile. The estimated hematological profile and the results of the blood investigation exhibit a reasonable correlation, according to the statistical analysis. A significant difference with DHF is also revealed by statistical analysis of the suggested method on other fever subjects. SVM classifiers were assigned this combination of estimated hematological features to categorize the risk category as either Normal, Low-Risk Dengue, or High-Risk Dengue. From the confusion matrix, the OAA SVM Classifier's overall accuracy was determined to be 98.90%, opening the door to the possibility of using it as a noninvasive prognostic system for tracking DHF subjects. [ABSTRACT FROM AUTHOR]
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- 2025
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8. Improve Strategy for Transient Power Angle Stability Control of VSG Combining Frequency Difference Feedback and Virtual Impedance.
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Wang, Dianlang, Yin, Qi, Wang, Haifeng, Chen, Jing, Miao, Hong, and Chen, Yihan
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SYNCHRONOUS generators ,ELECTRIC impedance ,PID controllers ,REACTIVE power control ,ELECTRIC power system stability - Abstract
As the penetration rate of distributed energy increases, the transient power angle stability problem of the virtual synchronous generator (VSG) has gradually become prominent. In view of the situation that the grid impedance ratio (R/X) is high and affects the transient power angle stability of VSG, this paper proposes a VSG transient power angle stability control strategy based on the combination of frequency difference feedback and virtual impedance. To improve the transient power angle stability of the VSG, a virtual impedance is adopted in the voltage loop to adjust the impedance ratio R/X; and the PI control feedback of the VSG frequency difference is introduced in the reactive power-voltage link of the VSG to enhance the damping effect. The second-order VSG dynamic nonlinear model considering the reactive power-voltage loop is established and the influence of different proportional integral (PI) control parameters on the system balance stability is analyzed. Moreover, the impact of the impedance ratio R/X on the transient power angle stability is presented using the equal area criterion. In the simulations, during the voltage dips with the reduction of R/X from 1.6 to 0.8, Δδ
1 is reduced from 0.194 rad to 0.072 rad, Δf1 is reduced from 0.170 to 0.093 Hz, which shows better transient power angle stability. Simulation results verify that compared with traditional VSG, the proposed method can effectively improve the transient power angle stability of the system. [ABSTRACT FROM AUTHOR]- Published
- 2025
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9. Association of Initial and Changes in Serum A-FABP Level With the Development and Improvement of Presarcopenia.
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Hu, Tingting, Xu, Yiting, Li, Xiaoya, Xiao, Yunfeng, Wang, Yufei, Bao, Yuqian, and Ma, Xiaojing
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MAGNETIC resonance imaging ,MUSCLE mass ,BIOELECTRIC impedance ,SKELETAL muscle ,LONGITUDINAL method - Abstract
Context Several cross-sectional studies have reported the association between serum adipocyte fatty acid–binding protein (A-FABP) level and presarcopenia. However, data on the effects of serum A-FABP level and its changes over time on the development and improvement of presarcopenia are scarce. Objective This study aimed to explore the association of serum A-FABP level with the incidence and improvement of presarcopenia in a community-based cohort, and further investigated the association of changes in serum A-FABP level with the incidence and improvement of presarcopenia. Methods This longitudinal cohort study included 1496 adults (41.2% men; median age, 58 [53-63] years) in 2013 to 2014 and was followed up to 2015 to 2016. Participants underwent serum A-FABP level measurements at baseline and a follow-up visit. Visceral fat area (VFA) was measured using magnetic resonance imaging. Skeletal muscle mass (SMM) was estimated by bioelectrical impedance analysis and converted to a skeletal muscle index (SMI). Presarcopenia was defined as SMI less than 1 SD of the sex-specific mean for the young reference group. Results During an average follow-up period of 2.1 years, baseline serum A-FABP level was positively associated with the incidence of presarcopenia (standardized by weight: risk ratio [RR] 3.22; 95% CI, 1.96-5.38; standardized by VFA: RR 2.11, 95% CI, 1.29-3.51) and negatively associated with the improvement of presarcopenia (standardized by weight: RR 0.66; 95% CI, 0.45-0.97; standardized by VFA: RR 0.71; 95% CI, 0.54-0.94), regardless of whether SMM was standardized by weight or VFA. Moreover, changes in serum A-FABP level provided additional information on the incidence and improvement of presarcopenia, independent of baseline serum A-FABP level (all P <.05). Conclusion Baseline serum A-FABP level and its changes were positively associated with the incidence and negatively associated with the improvement of presarcopenia. [ABSTRACT FROM AUTHOR]
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- 2025
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10. Associations of Regional Body Fat With Risk of Cardiovascular Disease and Mortality Among Individuals With Type 2 Diabetes.
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Qiu, Zixin, Lee, Dong Hoon, Lu, Qi, Li, Rui, Zhu, Kai, Li, Lin, Li, Ruyi, Pan, An, Giovannucci, Edward L, and Liu, Gang
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BIOELECTRIC impedance ,CARDIOVASCULAR disease related mortality ,TYPE 2 diabetes ,FAT ,MORTALITY - Abstract
Context It is largely unknown whether regional fat accumulation is associated with risk of cardiovascular disease (CVD) and mortality among individuals with type 2 diabetes (T2D), who often exhibit changes in relative fat distribution and have increased CVD risk. Objective To prospectively examine the association between regional body fat and risk of CVD in individuals with T2D and to determine whether the associations are independentof traditional measures of obesity. Methods The main analysis included 21 472 participants with T2D from the UK Biobank. Regional body fat was measured by bioelectric impedance assessment. Cox proportional-hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results Over a median of 7.7 years of follow-up, 3976 CVD events occurred. After multivariable adjustment, upper and lower body fat were independently and oppositely associated with CVD risk among patients with T2D. Higher arm fat percentage was linearly associated with increased CVD risk (P
nonlinear >.05), while higher trunk fat percentage was nonlinearly associated with increased CVD risk (Pnonlinear <.05). In contrast, higher leg fat percentage was nonlinearly associated with lower CVD risk (Pnonlinear <.05). When comparing extreme quartiles, the multivariable-adjusted HR (95% CI) of CVD was 0.72 (0.58-0.90) for leg fat percentage, 1.63 (1.29-2.05) for arm fat percentage, and 1.27 (1.06-1.52) for trunk fat percentage. Similar patterns of associations were observed for all-cause and CVD mortality. In addition, leg fat percentage, but not other regional fat percentage, was associated with CVD risk independently of traditional measures of obesity. Conclusion Among people with T2D, arm fat and trunk fat were positively, whereas leg fat was inversely, associated with the risk of CVD and mortality. These findings highlight the importance of considering both the amount and the location of body fat when assessing CVD and mortality risk among individuals with T2D. [ABSTRACT FROM AUTHOR]- Published
- 2025
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11. A novel electrochemical sensing strategy for determination of zearalenone in corn and wheat samples.
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Fei, Ximing
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ANALYTICAL chemistry ,AGRICULTURE ,ELECTROCHEMICAL sensors ,ELECTRIC impedance ,CYCLIC voltammetry - Abstract
In the present research, a novel and effective electrochemical sensing strategy for the trace measurement of zearalenone (ZEA) was investigated. The sensing platform is based on a Vulcan XC-72R carbon (VC)-Metal azolate framework (MAF) composite, which was utilized to modify a low expense carbon paste electrode (VC-MAF/CPE). The electrochemical characterization of the VC-MAF/CPE was studied using cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry and electrical impedance spectroscopy (EIS) analyses. The effect of buffer pH, modifier dosage and buffer type were also optimized using differential pulse voltammetry (DPV) method. The calibration range for ZEA detection was found to be 0.8 to 110 ng mL
− 1 under optimal experimental conditions. The detection limit was calculated to be 0.15 ng mL− 1 , based on S/N = 3. The selectivity of the sensor was evaluated against various interferents, including dopamine, ascorbic acid, glucose, fructose, and sucrose. Real sample analysis was successfully conducted using the suggested assay, demonstrating its applicability for ZEA detection in corn and wheat samples. In addition, the sensor exhibited good reproducibility with RSD value of 3.25%. This work shows the effectiveness of the VC-MAF/CPE sensor for ZEA determination in agricultural samples. [ABSTRACT FROM AUTHOR]- Published
- 2025
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12. Impact of nutritional status and pulmonary function on short- and long-term overall survival in hemodialysis patients.
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Aydın Güçlü, Özge, Erol, Hasim Atakan, Acet Öztürk, Nilüfer Aylin, Gorek Dilektasli, Asli, Coskun, Funda, Yıldız, Abdulmecid, and Karadag, Mehmet
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PULMONARY function tests , *CHRONIC kidney failure , *NUTRITIONAL assessment , *BODY composition , *BIOELECTRIC impedance - Abstract
Background: End-stage renal disease (ESRD) patients frequently experience protein-energy wasting (PEW), which increases their morbidity and mortality rates. Objective: This study explores the effects of nutritional status and pulmonary function on the short- and long-term mortality of ESRD patients undergoing hemodialysis. Materials and methods: 67 consecutive ESRD patients on maintenance hemodialysis were included in the study. The primary outcomes were all-cause one-year and five-year mortality. Data on demographic characteristics, comorbidities, and laboratory findings were collected. Pulmonary function tests were conducted along with body composition measurements using bioelectrical impedance analysis (BIA). Malnutrition was assessed using the Prognostic Nutritional Index (PNI). Results: The median age of the patients was 60.9 ± 12.4 years, with 58.3% being male. Pulmonary function parameters (FEV1 and FVC) were significantly associated with short-term mortality. The PNI was a significant predictor of both short-term and long-term mortality. A PNI score ≤ 39.01 was associated with increased short-term mortality (HR: 0.65, 95% CI: 0.48–0.88, p = 0.006), while a score ≤ 40 was linked to increased long-term mortality (HR: 0.80, 95% CI: 0.67–0.95, p = 0.015). Additionally, older age (HR: 1.06, 95% CI: 1.01–1.12, p = 0.021) and higher glomerular filtration rate (GFR) (HR: 1.23, 95% CI: 1.02–1.42, p = 0.024) were related to increased long-term mortality risk. Conclusion: The study demonstrates that PNI, age, and pulmonary function are critical factors influencing the survival of hemodialysis patients. These findings underscore the importance of comprehensive nutritional and pulmonary assessment to improve clinical outcomes in this population. [ABSTRACT FROM AUTHOR]
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- 2025
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13. Digital twin driven electrode optimization for wearable bladder monitoring via bioimpedance.
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Crane, H. Trask, Berkebile, John A., Mabrouk, Samer, Riccardelli, Nicholas, and Inan, Omer T.
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MORTALITY prevention ,BLADDER physiology ,DRINKING (Physiology) ,WEARABLE technology ,BIOELECTRIC impedance ,HEART failure ,DESCRIPTIVE statistics ,PATIENT monitoring ,DATA analysis software ,ELECTRODES - Abstract
Monitoring fluid intake and output for congestive heart failure (CHF) patients is an essential tool to prevent fluid overload, a principal cause of hospital admissions. Addressing this, bladder volume measurement systems utilizing bioimpedance and electrical impedance tomography have been proposed, with limited exploration of continuous monitoring within a wearable design. Advancing this format, we developed a conductivity digital twin from radiological data, where we performed exhaustive simulations to optimize electrode sensitivity on an individual basis. Our optimized placement demonstrated an efficient proof-of-concept volume estimation that required as few as seven measurement frames while maintaining low errors (CI 95% −1.11% to 1.00%) for volumes ≥100 mL. Additionally, we quantify the impact of ascites, a common confounding condition in CHF, on the bioimpedance signal. By improving monitoring technology, we aim to reduce CHF mortality by empowering patients and clinicians with a more thorough understanding of fluid status. [ABSTRACT FROM AUTHOR]
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- 2025
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14. Phase angle in bioelectrical impedance analysis for assessing congestion in acute heart failure.
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Sohn, Sangho, Jeon, Jinsung, Lee, Ji Eun, Park, Soo Hyung, Kang, Dong Oh, Park, Eun Jin, Lee, Dae-In, Choi, Jah Yeon, Roh, Seung Young, Na, Jin Oh, Choi, Cheol Ung, Kim, Jin Won, Rha, Seung Woon, Park, Chang Gyu, Lee, Sunki, and Kim, Eung Ju
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BIOELECTRIC impedance , *RECEIVER operating characteristic curves , *PATIENT self-monitoring , *HEART failure , *BODY fluids - Abstract
Background: The phase angle (PhA) in bioelectrical impedance analysis (BIA) reflects the cell membrane integrity or body fluid equilibrium. We examined how the PhA aligns with previously known markers of acute heart failure (HF) and assessed its value as a screening tool. Methods: PhA was measured in 50 patients with HF and 20 non-HF controls along with the edema index (EI), another BIA parameter suggestive of edema. Chest computed tomography-measured lung fluid content (LFC) was used to assess pulmonary congestion. A correlation analysis was conducted to evaluate the relationships between PhA and EI, NT-proBNP, and LFC. Receiver operating characteristic (ROC) curve analysis was used to determine the cut-off values for PhA and EI for classifying patients with HF. The area under the curve (AUC) was compared using the DeLong test to evaluate the performance of PhA and EI compared to that of LFC in correctly classifying HF. Results: The PhA levels were significantly lower in the HF group. Whole-body PhA was 4.49° in the HF group and 5.68° in the control group. Moderate and significant correlation was observed between PhA measured at 50-kHz and both NT-proBNP (-0.56 to -0.27, all p-values<0.05) and LFC (-0.52 to -0.41, all p-values <0.05). The AUC for whole-body PhA was 0.827 (confidence interval [CI] 0.724–0.931, p<0.01) and was 0.883 (CI 0.806–0.961, p<0.01) for EI, and the optimal cutoffs were estimated as 5° (sensitivity 0.84, specificity 0.80) and 0.394 (sensitivity 0.78, specificity 0.95), respectively. When both PhA and EI were included in the model, the AUC increased to 0.905, and this was comparable to that of LFC (AUC = 0.913, p = 0.857). Conclusions: PhA exhibited a correlation with known markers of HF and demonstrated its potential as a non-invasive screening tool for the early detection of HF exacerbation. The combined use of PhA and EI can provide a robust alternative for routine self-monitoring in patients with HF, thereby enhancing early intervention. [ABSTRACT FROM AUTHOR]
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- 2025
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15. Evaluating the impact of visceral fat on the outcomes of frozen embryo transfer via bioelectrical impedance analysis.
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Ni, Danyu, Wei, Yi, Xie, Qijun, Wang, Xinyu, Yu, Kaidi, Jiang, Wei, Yang, Ye, and Ling, Xiufeng
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PREGNANCY outcomes ,BIOELECTRIC impedance ,REPRODUCTIVE technology ,EMBRYO transfer ,EMBRYO implantation ,FROZEN human embryos - Abstract
Objectives: The increasing prevalence of obesity underscores the need to explore its impact on assisted reproductive technology (ART) outcomes. This study aims to evaluate the association between visceral fat area (VFA), measured by bioelectrical impedance analysis (BIA), and pregnancy outcomes following frozen embryo transfer (FET). Methods: In this retrospective clinical study, the data of 1,510 patients who underwent FET between April 2022 and April 2023 were analyzed. The VFA was measured by BIA, and patients were categorized into low and high VFA groups based on a threshold of 65 cm². Pregnancy outcomes were compared between the two groups. Univariable and multivariate logistic regression analyses, along with restricted cubic spline (RCS) modeling, were used to adjust for age, body mass index (BMI), and basal estradiol (E2) levels to determine the relationship between VFA and FET outcomes. Results: There were significant differences in baseline characteristics and outcomes between the two groups. The high VFA group was characterized by older age and a lower basal estradiol (E2) level. The biochemical pregnancy rate, implantation rate, clinical pregnancy rate (CPR), and live birth rate (LBR) were significantly lower in the high VFA group. Logistic regression revealed a significant negative correlation between the high VFA group and both CPR and LBR. The RCS model demonstrated that the VFA was nonlinearly correlated with CPR and LBR. Subgroup analysis showed that among individuals under 35 years of age or with a BMI < 24, high VFA was significantly associated with poorer CPR and LBR. Conclusions: High VFA is associated with poorer pregnancy outcomes after FET in female patients with infertility, with both CPR and LBR decreasing as VFA increases. Clinicians should consider VFA as an important reference for targeted fat management interventions to optimize reproductive success, especially when VFA exceeds 65 cm². [ABSTRACT FROM AUTHOR]
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- 2025
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16. Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass.
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Vargas-Errázuriz, Patricio, Dreyse, Natalia, López, René, Cano-Cappellacci, Marcelo, Graf, Jerónimo, and Guerrero, Julia
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MUSCLE mass ,BIOELECTRIC impedance ,BIOMARKERS ,CRITICALLY ill ,MULTIVARIATE analysis - Abstract
Assessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°) derived from bioelectrical impedance analysis (BIA) as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DCE), a structural and metabolic muscle mass marker. In 20 ICU patients, we observed a linear relationship between PA° and DCE at initial (S1) and follow-up (S2) points, with Rho values of 0.78 and 0.65, respectively, as well as between their percentage changes (Rho = 0.80). Multivariate analysis confirmed a strong association between changes in PA° and DCE (adjusted R
2 of 0.73), while changes in the extracellular water to total body water (ECW/TBW) ratio showed no significant association. This study establishes a relationship between a BIA-derived independent-weight parameter and DCE, highlighting the potential of PA° for muscle mass monitoring during acute changes, such as those seen in ICU settings. Integrating PA° into clinical practice could provide a non-invasive and reliable tool to enhance muscle assessment and support targeted interventions in critically ill patients. [ABSTRACT FROM AUTHOR]- Published
- 2025
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17. Fluoxetine exerts anti-proliferative effect in human epidermal keratinocytes.
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Ádám, Dorottya, Arany, József, Tóth, Kinga Fanni, Póliska, Szilárd, Váradi, Judit, Kolozsi, Péter, Tóth, Dezső, Niehues, Hanna, van den Bogaard, Ellen H., Soeberdt, Michael, Abels, Christoph, and Oláh, Attila
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PHOSPHATIDYLINOSITOL 3-kinases , *ELECTRIC impedance , *GENE expression , *KERATINOCYTES , *ENDOTHELINS - Abstract
We have recently shown that fluoxetine (FX) suppressed polyinosinic-polycytidylic acid-induced inflammatory response and endothelin release in human epidermal keratinocytes, via the indirect inhibition of the phosphoinositide 3-kinase (PI3K)-pathway. Because PI3K-signaling is a positive regulator of the proliferation, in the current, highly focused follow-up study, we assessed the effects of FX (14 µM) on the proliferation and differentiation of human epidermal keratinocytes. We found that FX exerted anti-proliferative actions in 2D cultures (HaCaT and primary human epidermal keratinocytes [NHEKs]; 48- and 72-h; CyQUANT-assay) as well as in 3D reconstructed epidermal equivalents (48-h; Ki-67 immunohistochemistry). Importantly, FX did not influence epidermal thickness (hematoxylin-eosin staining), and it did not have a major impact on the differentiation-associated alteration of the gene expression pattern (24-h treatments; RNA-Seq). Moreover, neither keratin (K)-1, nor K10 expression was altered by FX in NHEKs (RT-qPCR) or in 3D epidermal equivalents (semi-quantitative immunohistomorphometry). FX did not influence differentiation-induced up-regulation of occludin (RT-qPCR; NHEKs), and did not alter differentiation-associated barrier forming capacity of epidermal keratinocytes (electrical impedance; Lucifer Yellow penetration assay). Our data indicate that, besides the previously reported combined anti-inflammatory and putative anti-pruritic effects, FX may also suppress proliferation of human epidermal keratinocytes without impairing their differentiation and barrier-forming capacity. [ABSTRACT FROM AUTHOR]
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- 2025
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18. Portable devices for periodic monitoring of bioelectrical impedance along meridian pathways in healthy individuals.
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Xu, Yu-Chen, Cao, Xiu-Yan, Liu, Shuai, Liu, Bo, Chen, Hao, Cheng, Min, and Ye, Wei-Hua
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BIOELECTRIC impedance , *CHINESE medicine , *LARGE intestine , *SMALL intestine , *SPLEEN - Abstract
Objective: This study aims to investigate the monthly variation patterns of bioelectrical impedance (BEI) along 24 meridian pathways in healthy individuals. Methods: A cohort of 684 healthy middle-aged participants from North China was enrolled between July 1, 2017, and September 5, 2020. BEI measurements were consistently recorded along the 24 meridian pathways over the study period. The collected BEI data were subjected to statistical analysis, and line charts were constructed to depict the temporal variation patterns. Results: Analysis revealed that BEI values along the 24 meridian pathways followed a normal distribution over a 12-month period. In the first group of meridians, which includes the lung, large intestine, heart, small intestine, pericardium, and triple-energizer meridians, significant monthly variations were observed. The second group, comprising the spleen, stomach, bladder, kidney, gallbladder, and liver meridians, exhibited marked differences primarily between March and April (P < 0.05), with a peak in April and relatively stable values thereafter. Synchronous BEI fluctuations were evident on the left and right sides of the body, and both groups of meridian pathways displayed similar variation patterns. These patterns largely corresponded to fluctuations observed in the spleen meridian. Conclusion: The consistent monthly variation patterns in BEI along the 24 meridian pathways among healthy middle-aged individuals align with Traditional Chinese Medicine (TCM) concepts of meridians and collaterals. The spleen meridian, in particular, appears to play a crucial role in influencing these bioelectrical fluctuations, as posited in TCM theory. From a bioelectrical standpoint, this study provides empirical support for the potential existence and functionality of meridians and collaterals, offering a scientific perspective that complements ancient TCM principles. [ABSTRACT FROM AUTHOR]
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- 2025
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19. Advances in the estimation of body fat percentage using an artificial intelligence 2D-photo method.
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Ferreira, Tathiany J., Salvador, Igor C., Pessanha, Carolina R., da Silva, Renata R. M., Pereira, Aline D., Horst, Maria A., Carvalho, Denise P., Koury, Josely C., and Pierucci, Anna P. T. R.
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PHOTON absorptiometry ,CROSS-sectional method ,ADIPOSE tissues ,RESEARCH funding ,SKINFOLD thickness ,ARTIFICIAL intelligence ,PHOTOGRAPHY ,BIOELECTRIC impedance - Abstract
There is a growing need to evaluate the agreement between the field methods and integrate artificial intelligence (AI) using two-dimensional (2D) photos for enhanced real-world analysis. This study evaluated the agreement between AI-2D photos and the clinical reference method, dual-energy X-ray absorptiometry (DXA) to estimate the body fat percentage (BFP). Other methods were also investigated, including skinfolds, A-mode ultrasound, and bioelectrical impedance analysis (BIA). This cross-sectional study was conducted on 1273 adults of both sexes. The Bland–Altman plots, Lin's Correlation Coefficient of Agreement (CCC), and error analyses were calculated. AI-2D photos demonstrated substantial agreement with DXA presenting the highest agreement (CCC ≥ 0.96) among all the investigated methods. InBody-270 and Omron HBF-514 BIA devices showed moderate agreement (CCC = 0.90 to 0.95) for all participants, age groups >30 years, and body mass index >25 kg/m
2 . AI-2D photos can be interchangeable with DXA, providing a practical, accessible alternative and an easy-to-use system for BFP estimation. [ABSTRACT FROM AUTHOR]- Published
- 2025
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20. Field-Programmable Gate Array (FPGA)-Based Lock-In Amplifier System with Signal Enhancement: A Comprehensive Review on the Design for Advanced Measurement Applications.
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Galaviz-Aguilar, Jose Alejandro, Vargas-Rosales, Cesar, Falcone, Francisco, and Aguilar-Avelar, Carlos
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ADDITIVE white Gaussian noise , *GATE array circuits , *BIOELECTRIC impedance , *PHASE detectors , *ELECTRIC impedance - Abstract
Lock-in amplifiers (LIAs) are critical tools in precision measurement, particularly for applications involving weak signals obscured by noise. Advances in signal processing algorithms and hardware synthesis have enabled accurate signal extraction, even in extremely noisy environments, making LIAs indispensable in sensor applications for healthcare, industry, and other services. For instance, the electrical impedance measurement of the human body, organs, tissues, and cells, known as bioelectrical impedance, is commonly used in biomedical and healthcare applications because it is non-invasive and relatively inexpensive. Also, due to its portability and miniaturization capabilities, it has great potential for the development of new point-of-care and portable testing devices. In this document, we highlight existing techniques for high-frequency resolution and precise phase detection in LIA reference signals from field-programmable gate array (FPGA) designs. A comprehensive review is presented under the key requirements and techniques for single- and dual-phase digital LIA architectures, where relevant insights are provided to address the LIAs' digital precision in measurement system configurations. Furthermore, the document highlights a novel method to enhance the spurious-free dynamic range (SFDR), thereby advancing the precision and effectiveness of LIAs in complex measurement environments. Finally, we summarize the diverse applications of impedance measurement, highlighting the wide range of fields that can benefit from the design of high performance in modern measurement technologies. [ABSTRACT FROM AUTHOR]
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- 2025
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21. Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study.
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Hernández, Aura Rocío, Sepulveda, Lady, Hata, Yoshie, Castellanos, Leonardo, Björklund, Sebastian, Ruzgas, Tautgirdas, and Aragón, Marcela
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ELECTRIC impedance , *IMPEDANCE spectroscopy , *LIGHT scattering , *SKIN cancer , *SARGASSUM - Abstract
Skin cancer is one of the most common types of cancer worldwide, with exposure to UVB radiation being a significant risk factor for its development. To prevent skin cancer, continuous research efforts have focused on finding suitable photoprotective ingredients from natural sources that are also environmentally friendly. This study aimed to develop oil-in-water photoprotective nanoemulsions containing marine macroalgae extract. A Box–Behnken experimental design was used to identify the most promising formulation composition, resulting in optimal physical properties. These properties, including droplet size, polydispersity index (PDI), and zeta potential, were evaluated using dynamic light scattering (DLS). To assess the photoprotection capacity of the formulations, electrical impedance spectroscopy (EIS) was employed to evaluate alterations in the electrical characteristics of excised pig skin membranes placed in Franz cells equipped with a 4-electrode set-up. The final composition of the nanoemulsion was caprylic/capric triglycerides 4%, Macrogolglycerol ricinoleate 30%, and algae extract 1%. The nanoemulsions had an average droplet size of 128.5 ± 8.6 nm, a PDI of 0.25 ± 0.06, and a zeta potential of 45.14 ± 0.02 mV. Compared to the control group, the photoprotective capacity of the oil-in-water nanoemulsions was statistically significant. Specifically, only a 15% reduction in the skin membrane electrical resistance following UVB exposure was observed when the formulation containing algae extract was used, whereas a 50% reduction was observed for the vehicle. In conclusion, this work demonstrates that the developed nanoemulsions based on natural ingredients show promising protective capacity against UVB exposure of the skin. [ABSTRACT FROM AUTHOR]
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- 2025
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22. Usefulness of body composition assessment by bioelectrical impedance vector analysis in subacute post-stroke patients in rehabilitation.
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Guerrini, Alessandro, Siotto, Mariacristina, Cocco, Carola, Germanotta, Marco, Cipollini, Valeria, Cortellini, Laura, Pavan, Arianna, Lattanzi, Stefania, Insalaco, Sabina, Khazrai, Yeganeh Manon, and Aprile, Irene Giovanna
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OLDER patients , *BODY composition , *BIOELECTRIC impedance , *MUSCLE mass , *VECTOR analysis - Abstract
Bioelectrical Impedance Vector Analysis (BIVA) is a valuable tool for evaluating hydration and body composition, but its application in subacute post-stroke patients remains unexplored. This study aimed to fill this gap by analyzing BIVA in a cohort of 87 subacute post-stroke patients (42 women, mean age 69 ± 12) undergoing rehabilitation. At admission (T0), diagnosis of malnutrition with GLIM criteria and of sarcopenia with EWGSOP2 was done, and patients were analyzed with BIVA. The change in modified Barthel Index (mBIT1-mBIT0) was assessed to evaluate the improvement in functional recovery. BIVA revealed that both adult patients (< 65 years, n = 29) and elderly patients (≥ 65 years, n = 58) exhibited high body fluid overload and low muscle mass. Additionally, BIVA revealed a significant rightward shift of the bioimpedance vectors in malnourished (n = 37) versus non-malnourished patients (T2 = 56.9, p < 0.001, D = 1.68) and in sarcopenic (n = 24) versus non-sarcopenic patients (T2 = 36.4, p < 0.001, D = 1.5). Lastly, the BIVA distinguished patients with greater improvement (n = 53) from patients with lower improvement (n = 34) (T2 = 10.6, p = 0.007, D = 0.7). In conclusion, BIVA is an effective, easy-to-use tool for evaluating hydration, nutritional status, and recovery in post-stroke rehabilitation. [ABSTRACT FROM AUTHOR]
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- 2025
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23. Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features.
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Qu, Shuoyao, Feng, Enzhi, Dong, Daihan, Yang, Lin, Dai, Meng, Frerichs, Inéz, Liu, Shaojie, Gao, Yi, Zheng, Jinping, Song, Liqiang, and Zhao, Zhanqi
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ELECTRIC impedance ,SPIROMETRY ,SENSITIVITY & specificity (Statistics) ,LUNGS - Abstract
Early detection of lung function impairment is crucial. However, the sensitivity of spirometry in detecting early lung function deterioration is limited. In this study, lungs of 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measurements were conducted in 130 participants with normal spirometry for concept establishment phase and 105 for validation phase. A follow-up CT examination was suggested for participants with abnormal regional time constant or tobacco consumption ≥10 pack-years. Using CT as reference, the sensitivity and specificity of electrical impedance tomography-based screening were 81.3% and 50.0%, respectively in the concept establishment phase. In the validation phase, the sensitivity and specificity were 77.9% and 50.0%. In this study we show that conventional spirometry may not capture early changes that occur at a regional level. The regional time constant based on electrical impedance tomography can be a promising tool for early screening of lung function impairment. Clinical trial registration: ChiCTR2300076673, www.chictr.org.cn. The study explores the possibility of using electrical impedance tomography (EIT) as an early screening method to identify lung function impairment in participants with normal spirometry results. It identifies EIT-based regional τ values can be a promising tool for early screening of lung function impairment. [ABSTRACT FROM AUTHOR]
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- 2025
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24. Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults.
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Mecherques-Carini, Malek, Albaladejo-Saura, Mario, Esparza-Ros, Francisco, Baglietto, Nicolás, and Vaquero-Cristóbal, Raquel
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BODY composition , *DUAL-energy X-ray absorptiometry , *ADIPOSE tissues , *FAT analysis , *BIOELECTRIC impedance - Abstract
Background: Accurate body fat distribution assessment is essential for managing cardiovascular disease and metabolic disorders. Although several methods are available for segmental fat analysis, few studies have examined the validity of affordable methods such as Bioelectrical Impedance Analysis (BIA) against the reference method, Dual-Energy X-ray Absorptiometry (DXA). This study aimed to assess the validity of BIA as compared to DXA for segmental fat mass assessment, and to develop anthropometric multivariate regression models that offer a cost-effective alternative for health professionals in clinical and public health settings. Methods: Cross-sectional study that included 264 young adults (161 males, mean age = 23.04 ± 5.61 years; and 103 females, mean age = 22.29 ± 5.98 years). Segmental fat mass was measured using DXA and BIA, and anthropometric measurements were collected following the ISAK protocol. Results: Significant differences were found between DXA and BIA for segmental fat mass (p < 0.001). Sex significantly influenced the results (p < 0.05), while BMI and hydration status had no significant impacts. The Bland-Altman analysis revealed significant differences (p < 0.001) between BIA and DXA for fat mass in the upper and lower limbs. Trunk fat mass also differed significantly in males and females (p < 0.001), except for the overall sample (p = 0.088). Anthropometric multivariate regression models showed a high predictive accuracy for both females (R²=0.766–0.910; p < 0.001) and males (R²=0.758–0.887; p < 0.001). Key predictors of segmental fat mass included body mass (r = 0.606–0.867; p < 0.001), skinfold thickness (r = 0.688–0.893; p < 0.001), and waist girth (r = 0.883 − 0.810; p < 0.001). Peripheral skinfolds were highly predictive for upper and lower limbs, while waist girth was relevant for trunk fat mass. Conclusions: DXA and BIA are not interchangeable for segmental fat analysis due to the significant differences observed. However, the anthropometric multivariate regression models developed provide a cost-effective and reliable alternative for predicting segmental fat mass in clinical settings where DXA is unavailable. Trial registration: Not applicable. [ABSTRACT FROM AUTHOR]
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- 2025
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25. Neutrophil-to-lymphocyte ratio as a novel predictor of sarcopenia in maintenance hemodialysis patients: a cross-sectional study exploring associations across body composition categories.
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M., Yogesh, Parmar, Parth Anilbhai, Sharma, Soumya, Kakadiya, Jay Pareshbhai, and Lakkad, Dhruv
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BODY composition , *NEUTROPHIL lymphocyte ratio , *BIOELECTRIC impedance , *SARCOPENIA , *HEMODIALYSIS patients - Abstract
Background: Sarcopenia is prevalent among hemodialysis patients and is associated with poor outcomes. The neutrophil-to-lymphocyte ratio (NLR), an easily obtainable marker of inflammation, may predict sarcopenia risk. This study aimed to investigate the association between NLR and sarcopenia risk in maintenance hemodialysis patients, examining this association in the context of obesity. Methods: This cross-sectional study included 411 maintenance hemodialysis patients. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria-2019 (AWGS 2019). Body composition was assessed using bioelectrical impedance analysis. Logistic regression models examined associations between NLR and sarcopenia risk, adjusting for potential confounders. Analyses were stratified by obesity status. Results: The prevalence of sarcopenia was 51% (95% CI: 45.1-54.9%), with 37.2% classified as sarcopenic non-obese and 13.6% as sarcopenic obese. In fully adjusted models, each unit increase in NLR was associated with 10% higher odds of sarcopenia overall (OR 1.10, 95% CI: 1.00-1.21, p = 0.048). This association remained significant in sarcopenic obese patients (OR 1.15, 95% CI: 1.00-1.32, p = 0.049). Patients in the highest NLR tertile had 1.95 times higher odds of sarcopenia compared to the lowest tertile (95% CI: 1.12–3.40, p = 0.018), with a significant trend across tertiles (p-trend = 0.015). Conclusions: NLR is independently associated with sarcopenia risk in hemodialysis patients, including those with obesity. These findings suggest NLR could serve as a simple, cost-effective tool for identifying hemodialysis patients at high risk of sarcopenia, potentially facilitating early intervention strategies. [ABSTRACT FROM AUTHOR]
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- 2025
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26. Electrical impedance-based tissue classification for bladder tumor differentiation.
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Veil, Carina, Krauß, Franziska, Amend, Bastian, Fend, Falko, and Sawodny, Oliver
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ELECTRIC impedance , *TISSUE differentiation , *GAUSSIAN processes , *FEATURE extraction , *DEFORMATIONS (Mechanics) - Abstract
Including sensor information in medical interventions aims to support surgeons to decide on subsequent action steps by characterizing tissue intraoperatively. With bladder cancer, an important issue is tumor recurrence because of failure to remove the entire tumor. Impedance measurements can help to classify bladder tissue and give the surgeons an indication on how much tissue to remove. Over the years of research, it became obvious that electrical impedance spectroscopy is a very promising tool for tissue differentiation, but also a very sensitive one. While differentiation in preliminary studies shows great potential, challenges arise when transferring this concept to real, intraoperative conditions, mainly due to the influence of preoperative radiotherapy, possibly different tumor types, and mechanical tissue deformations due to peristalsis or unsteady contact force of the sensor. This work proposes a patient-based classification approach that evaluates the distance of an unknown measurement to a healthy reference of the same patient, essentially a relative classification of the difference in impedance that is robust against inter-individual differences and systematic errors. A diversified dataset covering multiple disturbance scenarios is recorded. Two alternatives to define features from the impedance data are investigated, namely using measurement points and model-based parameters. Based on the distance of the feature vector of a unknown measurement to a healthy reference, a Gaussian process classifier is trained. The approach achieves a high classification accuracy of up to 100% on noise-free impedance data recorded under controlled conditions. Even when the differentiation is more ambiguous due to external disturbances, the presented approach still achieves a classification accuracy of 80%. These results are a starting point to tackle intraoperative bladder tissue characterization and decrease the recurrence rate. [ABSTRACT FROM AUTHOR]
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- 2025
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27. Investigation into the Characteristics of Nanoporous Carbon/Silica-Nickel Nanocomposite for high-frequency Applications.
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Sayari, F., Mansour, N. Ben, Kraini, M., Wederni, M. A., Hjiri, M., Aouaini, F., Sharma, A., and El Mir, L.
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EQUIVALENT electric circuits , *ELECTRIC impedance , *HOPPING conduction , *ELECTRIC conductivity , *FOURIER transform infrared spectroscopy , *NICKEL oxides - Abstract
The synthesis process involved integrating nickel oxide nanoparticles into a Carbon/Silica host matrix using the sol-gel method, resulting in the formation of a Carbon/Silica-Nickel nanocomposite. This nanocomposite was subjected to pyrolysis at 650 °C for two hours.The XRD diffractogram revealed a broad diffraction peak characteristic of amorphous silica and carbon phases, alongside three distinct peaks attributed to nickel. The XPS analysis identified five prominent peaks corresponding to Si 2p, Si 2s, C 1s, O 1s, and Ni 2p. SEM and TEM images showcased the porous texture and agglomeration of nanoparticles, respectively. FTIR spectroscopy indicated the presence of three major peaks associated with Si-O-Si, C-C, and Ni-O vibrations. Raman spectroscopy showed that electrical conduction is facilitated by the graphite nanoparticles. The direct current electrical conductivity (σdc) was exploited using Variable Range Hopping and Nearest Neighbor Hopping conduction models. The alternating current electrical conductivity (σac) suggested the dominance of the Overlapping Large Polaron Tunnelling model. The complex impedance and electrical modulus were studied to determine the equivalent circuit and understand the electric relaxation process. The dielectric properties explained the occurrence of Maxwell-Wagner interfacial polarization. [ABSTRACT FROM AUTHOR]
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- 2025
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28. A novel microfluidic chip based on an impedance-enhanced electrochemical immunoassay.
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Tsai, Sung-Lin, Wey, Jiunn-Jye, Lai, Szu-Chia, and Huang, Yu-Yin
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EMERGING infectious diseases , *ELECTRIC impedance , *MICROFLUIDIC devices , *VIRAL proteins , *ELECTRONIC equipment , *IMMUNOASSAY - Abstract
Electrochemical immunoassays have been employed in clinical diagnostics for a considerable duration. The use of microspheres or microbeads as carriers for biomarkers serves as a foundational platform for biochemical testing. In conventional electrochemical immunoassays, constant potential instruments are predominantly utilized to measure current variations on the electrode surface, thereby achieving optimal sensitivity. However, the bio-modified electrode surface introduces complexities in cleaning, separation, and other applications. We present a novel microfluidic device based on an impedance-enhanced electrochemical immunoassay that introduces a continuous fluid quantitative platform that employs freely moving multiplex beads containing antigens bound to magnetic and dielectric micro/nanobeads, which are measured using an electrochemical impedance biosensor, all within a one-way microchannel of a microfluidic chip. This device utilizes antibody-coated magnetic beads and dielectric beads conjugated with detection antibodies for quantitative analysis in conjunction with portable electronic devices. Additionally, we have developed an innovative algorithm for microbead analysis based on the modeling of coplanar electrodes to detect viral proteins. This unique bead-based technology has been successfully integrated into a microfluidic chip and proved to have effectively detected COVID-19. The proposed device leverages bead-based technology and electrical impedance characteristics, offering substantial potential for integration with miniaturized electronic elements. This microfluidic device facilitates simple, rapid, efficient, portable, compact, and cost-effective high-throughput measurements, thereby enhancing clinical diagnostic capabilities for emerging infectious diseases. [ABSTRACT FROM AUTHOR]
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- 2025
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29. The Influence of Body Composition, Lifestyle, and Dietary Components on Adiponectin and Resistin Levels and AR Index in Obese Individuals.
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Polak-Szczybyło, Ewelina and Tabarkiewicz, Jacek
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MONOUNSATURATED fatty acids , *ADIPOSE tissues , *BODY mass index , *BIOELECTRIC impedance , *ADIPONECTIN , *ADIPOKINES , *RESISTIN - Abstract
Adipose tissue of obese people secretes a number of adipokines, including adiponectin and resistin, which have an antagonistic effect on the human metabolism, influencing the pathogenesis of many diseases based on low-grade inflammation. Body composition analysis using bioelectrical impedance analysis (BIA) was performed in 84 adults with obesity, i.e., body mass index (BMI) greater than or equal to 30 kg/m2. Serum was collected to analyze the concentration of adiponectin (ApN) and resistin. The subjects additionally completed a food frequency questionnaire FFQ-6 and a three-day food diary. Adiponectin-resistin index (AR index) was calculated. The results show a positive correlation between resistin levels and BMI and subcutaneous fat content. AR index value was also positively associated with the amount of adipose tissue and body mass. Adiponectin level in the serum of the studied individuals decreased with the content of lean tissue. Adiponectin level also decreased with the amount of carbohydrates, amount of starch, and glycemic load of the diet. Resistin decreased in patients who frequently consumed white pasta and red meat, while AR index was positively associated with the amount of white rice and saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) consumed but negatively associated with the frequent consumption of carbohydrates, including starch. Physical activity was negatively correlated with adiponectin levels and AR index. We concluded that body composition significantly influenced serum resistin and adiponectin concentrations the AR index. Dietary components also had a significant effect. [ABSTRACT FROM AUTHOR]
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- 2025
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30. Relationship Between Diaphragm Function and Sarcopenia Assessed by Ultrasound: A Cross-Sectional Study.
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Shinohara, Takahiro, Yamada, Toru, Ouchi, Shuji, Mabuchi, Suguru, Hanazawa, Ryoichi, Nakagawa, Kazuharu, Yoshimi, Kanako, Mayama, Tatsuya, Horike, Ayane, Toyoshima, Kenji, Tamura, Yoshiaki, Araki, Atsushi, Tohara, Haruka, Hirakawa, Akihiro, Kimura, Takuma, Ishida, Takeshi, and Hashimoto, Masayoshi
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PULMONARY function tests , *MUSCLE mass , *BIOELECTRIC impedance , *SARCOPENIA , *SKELETAL muscle - Abstract
Background/Objectives: The diaphragm is important for respiration, but the effects of age-related muscle loss and sarcopenia on diaphragm function are unclear. We evaluated the associations of sarcopenia and skeletal muscle mass (SMM) with diaphragm function. Methods: This study was conducted at three Japanese hospitals from May 2023 to September 2024. The participants underwent bioelectrical impedance for SMM assessment, as well as pulmonary function tests. Diaphragm ultrasound was used to measure the thickness at functional residual capacity (FRC), thickening fraction (TF), and diaphragm excursion (DE) during deep breathing (DB), and their associations with sarcopenia and low skeletal muscle index (SMI) were analyzed. Results: Overall, 148 patients (mean age 78.1 years; sarcopenia, n = 35; non-sarcopenia, n = 103) were included. No statistically significant differences in thickness(FRC), TF and DE were observed between the sarcopenia group and the non-sarcopenia group. The low SMI group had significantly lower thickness (difference −0.22, 95% CI; −0.41, −0.29) and DE (difference −9.2, 95%CI; −14.0, −4.49) than the normal SMI group. Multivariable linear regression analyses adjusted for age, sex, and stature revealed no association between thickness (FRC) and sarcopenia (p = 0.98), but thickness (FRC) was negatively associated with low SMI (p = 0.034). DE during DB was negatively associated with sarcopenia (p = 0.024) and low SMI (p = 0.001). TF showed no associations. Conclusions: DE during DB was reduced in patients with sarcopenia and low SMI, and thickness (FRC) was reduced in those with low SMI without sarcopenia. [ABSTRACT FROM AUTHOR]
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- 2025
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31. Trying to Kill a Killer; Impressive Killing of Patient Derived Glioblastoma Cultures Using NK-92 Natural Killer Cells Reveals Both Sensitive and Highly Resistant Glioblastoma Cells.
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Yu, Jane, Kim, Hyeon Joo, Reinecke, Jordyn, Hucklesby, James, Read, Tennille, Anchan, Akshata, Angel, Catherine E., and Graham, Euan Scott
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KILLER cells , *BRAIN tumors , *ELECTRIC impedance , *GLIOBLASTOMA multiforme , *CELL death - Abstract
The overall goal of this work was to assess the ability of Natural Killer cells to kill cultures of patient-derived glioblastoma cells. Herein we report impressive levels of NK-92 mediated killing of various patient-derived glioblastoma cultures observed at ET (effector: target) ratios of 5:1 and 1:1. This enabled direct comparison of the degree of glioblastoma cell loss across a broader range of glioblastoma cultures. Importantly, even at high ET ratios of 5:1, there are always subpopulations of glioblastoma cells that prove very challenging to kill that evade the NK-92 cells. Of value in this study has been the application of ECIS (Electric Cell–Substrate Impedance Sensing) biosensor technology to monitor the glioblastoma cells in real-time, enabling temporal assessment of the NK-92 cells. ECIS has been powerful in revealing that at higher ET ratios, the glioblastoma cells are acutely sensitive to the NK-92 cells, and the observed glioblastoma cell death is supported by the high-content imaging data. Moreover, long-term ECIS experiments reveal that the surviving glioblastoma cells were then able to grow and reseed the culture, which was evident 300–500 h after the addition of the NK-92 cells. This was observed for multiple glioblastoma lines. In addition, our imaging provides evidence that some NK-92 cells appear to be compromised early, which would be consistent with potent evasive mechanisms by the glioblastoma tumour cells. This research strongly highlights the potential for NK-92 cells to kill glioblastoma tumour cells and provides a basis to identify the mechanism utilised by the surviving glioblastoma cells that we now need to target to achieve maximal cytolysis of the resistant glioblastoma cells. It is survival of the highly resistant glioblastoma clones that results in tumour relapse. [ABSTRACT FROM AUTHOR]
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- 2025
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32. Independent Component Analysis-Based Harmonic Transfer Impedance Estimation for Networks with Multiple Harmonic Sources †.
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de Oliveira, Mateus M., Silva, Leandro R. M., Melo, Igor D., Duque, Carlos A., and Ribeiro, Paulo F.
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ELECTRIC power systems , *ELECTRIC impedance , *UNITS of measurement , *DATA mining , *PROBLEM solving , *INDEPENDENT component analysis - Abstract
This paper presents a novel methodology to estimate the harmonic transfer impedances in electric power systems with multiple harmonic sources (HSs). The purpose is to determine the responsibility of each HS for the total harmonic distortion at a specific bus within the system, addressing a critical issue in the power quality field. To achieve this objective, it is necessary to estimate not only the individual HS, but also the transfer impedances between each source and the bus under analysis (BUA). Most methods for solving this problem are based on proper network modeling or restrict variations in harmonic sources to a single source at a time. The proposed methodology has overcome this limitation. For this, synchronized current and voltage phasors are measured at the BUA. Once the measurements are gathered, the Independent Component Analysis (ICA) method is applied to estimate the Norton equivalent. The harmonic transfer impedance (HTI) is then determined using the information provided by the ICA. To enhance the accuracy of HTI estimation, three procedures are employed for data mining the parameters provided by ICA over time to generate a well-conditioned system. Once the HTI is satisfactorily determined, the individual harmonic contributions (IHCs), i.e., the harmonic responsibility, can be estimated accurately. The effectiveness and performance of the method are demonstrated based on computational simulations using distribution and transmission systems. Additionally, the methodology is validated with real data collected from a Brazilian transmission system monitored by synchronized power quality measurement units. Simulated results show that the Total Vector Error (TVE) is less than 0.4%, and for the field data test, the TVE is less than 2%. [ABSTRACT FROM AUTHOR]
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- 2025
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33. Effects of Benesco™ on Esophageal Sensitivity, Mucosal Barrier Function, and Reflux Symptoms: A Mechanistic Study.
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Kuipers, Thijs, Nijhuis, Renske A. B. Oude, Masclee, Gwen M. C., and Bredenoord, Albert J.
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MEDICAL sciences , *PROTON pump inhibitors , *ELECTRIC impedance , *GASTROESOPHAGEAL reflux ,WESTERN countries - Abstract
Introduction: Gastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal diseases in the western world. Proton pump inhibitors (PPIs) are the cornerstone of GERD management however a subset of patients seeks for (natural) alternative therapies. Benesco™ is an over-the-counter supplement, of which the active ingredient is quercetin and has a presumed positive effect on esophageal barrier function. The aim of this study was therefore to evaluate the effect of benesco™ on esophageal sensitivity, mucosal barrier function, and reflux symptoms. Methods: Patients with GERD were evaluated using acid perfusion tests, an upper endoscopy with electrical tissue impedance spectroscopy, and esophageal biopsies. Results: 8 patients (3 men, median age 45 (34–64)) were included. The perfusion sensitivity score (PSS) did not change significantly after treatment with benesco™ (90.5 (21.4–129.7) to 62.5 (16.4–96.9) p = 0.123). Esophageal sensitivity based on the maximum reported VAS score during the esophageal acid perfusion test did not change significantly after treatment with benesco™ (7.4 (5.3–9.8) to 7.7 (5.3–8.7) p = 0.482). Furthermore, no effects were seen on measures of mucosal barrier function such as extracellular in vivo impedance (ETIS) (6807 (5153–8883) Ω·m vs 6702 (5106–7847) Ω·m, p = 0.575), in vitro transepithelial electrical resistance (TEER) (183 (153–204) Ω.cm2 vs 201 (128–250) Ω.cm2, p = 1.000), or fluorescein flux (896 (73–1922) nmol/cm2/h vs 811 (187–2693) nmol/cm2/h, p = 0.237). Conclusion: We did not observe an improvement of acid perception, mucosal barrier function, or reflux symptoms by benesco™ in this study. Trial registration: Dutch Trial Register number: NL9324 [ABSTRACT FROM AUTHOR]
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- 2025
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34. Effects of muscle quantity, muscle quality, and phase angle on whole-body reaction time in 5164 adults aged 20–91 years.
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Fukuda, Wataru, Yoshihisa, Takeshi, and Yamada, Yosuke
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BIOELECTRIC impedance , *BODY mass index , *LEAN body mass , *PHYSICAL mobility , *MUSCLE strength - Abstract
Purpose: Muscle quantity, defined as appendicular lean mass (ALM); muscle quality, defined as the ratio of muscle strength to ALM; and bioelectrical impedance analysis (BIA)-derived phase angle (PhA) are determinants of physical performance. We examined whether muscle quality indices were significant predictors of the whole-body reaction time (WBRT) in healthy female and male adults aged 20–91 years. Methods: Data from 5164 adults (2869 women and 2295 men; mean age ± standard deviation, 60.9 ± 15.6 years) were analyzed. Height and weight were measured, and body mass index was calculated. ALM was estimated using a previously validated 8-electrode multi-frequency BIA. PhA was measured at 50 kHz using a BIA device. Knee extension strength (KES), leg extension power (LEP), and flexibility were examined. The ALM to weight (ALM/weight), KES to ALM (KES/ALM), and LEP to KES (LEP/KES) ratios were calculated. In the WBRT test, participants were asked to stand on a force plate and jump upright as quickly as possible in response to a light stimulus. The WBRT was divided into the response initiation and motion execution phases. Results: ALM/weight, KES/ALM, LEP/KES, PhA, and flexibility were significant independent predictors of WBRT and the time of the motion execution phase (p < 0.001). However, PhA was not a significant predictor of the time of response initiation phase. Conclusion: Muscle quantity (ALM/weight), muscle quality (KES/ALM and LEP/KES), PhA, and flexibility are determinants of WBRT test performance, particularly in the motion execution phase. [ABSTRACT FROM AUTHOR]
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- 2025
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35. Pre‐stroke patient characteristics that influence skeletal muscle quality: A cross‐sectional study.
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Honma, Keisuke, Honda, Yosuke, Nagase, Masahiro, Nakao, Yuta, Sota, Koichiro, Sasanuma, Naoki, Igeta, Masataka, Uchiyama, Yuki, and Domen, Kazuhisa
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FUNCTIONAL independence measure , *TYPE 2 diabetes , *MULTIPLE regression analysis , *SKELETAL muscle , *BIOELECTRIC impedance - Abstract
Aim Methods Results Conclusions One of the parameters that is measurable using bioelectrical impedance is the phase angle (PhA), which is an indicator of skeletal muscle quality. The PhA reflects cellular health and nutritional status and is an important parameter for monitoring recovery after stroke. However, the factors affecting skeletal muscle quality remain unclear. Therefore, this study aimed to identify the factors associated with skeletal muscle quality in patients with acute stroke.A total of 505 consecutively hospitalized patients with acute stroke were included in this study. The primary outcome was the PhA measured by bioelectrical impedance analysis, which evaluates muscle quality. Multiple regression analysis was performed to identify the factors affecting PhA.The mean age of the participants was 75.1 years, and 44% were female. The median National Institutes of Health Stroke Scale (NIHSS) score upon admission was 4, and the mean length of stay was 18 days. The mean PhA for skeletal muscle quality was 4.9° in males and 3.9° in females. Multiple regression analysis showed that age, sex, pre‐stroke modified Rankin Scale (pre‐mRS), Geriatric Nutritional Risk Index, type 2 diabetes mellitus, atrial fibrillation, and chronic kidney disease had independent effects on PhA (R2 = 0.575; P = 0.001). Age, pre‐mRS, NIHSS, dementia, and PhA independently associated with functional independence measure at discharge (R2 = 0.657; P = 0.001).This study identified determinants contributing to the deterioration of muscle quality upon admission in acute stroke patients. Further investigation is needed to ascertain whether modulation of these factors improves muscle quality.
Geriatr Gerontol Int 2025; ••: ••–•• . [ABSTRACT FROM AUTHOR]- Published
- 2025
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36. Characterization of temperature-dependent full-matrix constants of [001]c-poled Mn-doped 28PIN-43PMN-29PT single crystals using one sample.
- Author
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Zhang, Kai, Xiao, Ailing, Tang, Liguo, Xu, Guisheng, and Luo, Wenyu
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RESONANT ultrasound spectroscopy , *ELECTRIC impedance , *PIEZOELECTRIC devices , *PERMITTIVITY , *DIELECTRIC properties - Abstract
[001] c -poled Mn-doped xPb(In 1/2 Nb 1/2)O 3 –(1–x–y)Pb(Mg 1/3 Nb 2/3)O 3 –yPbTiO 3 (PIN–PMN–PT:Mn) single crystals (SCs) in the rhombohedral phase possess not only excellent piezoelectric properties but also a high mechanical quality factor, which make them suitable for fabricating high-performance piezoelectric devices. Characterizing the temperature dependence (TD) of full-matrix constants is indispensable for their use in device design. However, there is a significant lack of relevant data. In this study, the TD of the clamped dielectric properties of [001] c -poled 28PIN-43PMN-29PT:Mn SCs was characterized using a dielectric temperature spectroscopy measurement system from 0 to 60 °C. Their elastic and piezoelectric constants were measured using resonant ultrasound spectroscopy in the same temperature range. With an increase in the temperature, all the elastic stiffness constants decreased, whereas all the clamped dielectric constants and the absolute values of all the piezoelectric stress constants increased. The characterization process required only a single sample, which ensured the consistency of the results. Furthermore, the electrical impedance spectra of the sample at 30 and 50 °C were measured and compared with those simulated using the finite-element method with the characterization results. The close agreement between them confirmed the reliability of the characterization results. [ABSTRACT FROM AUTHOR]
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- 2025
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37. A Novel Point-of-Care Prediction Model for Steatotic Liver Disease: Expected Role of Mass Screening in the Global Obesity Crisis.
- Author
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Jeayeon Park, Goh Eun Chung, Yoosoo Chang, So Eun Kim, Won Sohn, Seungho Ryu, Yunmi Ko, Youngsu Park, Moon Haeng Hur, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, and Yoon Jun Kim
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MACHINE learning , *RECEIVER operating characteristic curves , *FATTY liver , *YOUNG adults , *BIOELECTRIC impedance - Abstract
Background/Aims: The incidence of steatotic liver disease (SLD) is increasing across all age groups as the incidence of obesity increases worldwide. The existing noninvasive prediction models for SLD require laboratory tests or imaging and perform poorly in the early diagnosis of infrequently screened populations such as young adults and individuals with healthcare dis- parities. We developed a machine learning-based point-of-care prediction model for SLD that is readily available to the broader population with the aim of facilitating early detection and timely intervention and ultimately reducing the burden of SLD. Methods: We retrospectively analyzed the clinical data of 28,506 adults who had routine health check-ups in South Korea from January to December 2022. A total of 229,162 individuals were included in the external validation study. Data were analyzed and predictions were made using a logistic regression model with machine learning algorithms. Results: A total of 20,094 individuals were categorized into SLD and non-SLD groups on the basis of the presence of fatty liver disease. We developed three prediction models: SLD model 1, which included age and body mass index (BMI); SLD model 2, which included BMI and body fat per muscle mass; and SLD model 3, which included BMI and visceral fat per muscle mass. In the derivation cohort, the area under the receiver operating characteristic curve (AUROC) was 0.817 for model 1, 0.821 for model 2, and 0.820 for model 3. In the internal validation cohort, 86.9% of individuals were correctly classified by the SLD models. The external validation study revealed an AUROC above 0.84 for all the models. Conclusions: As our three novel SLD prediction models are cost-effective, noninvasive, and accessible, they could serve as validated clinical tools for mass screening of SLD. [ABSTRACT FROM AUTHOR]
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- 2025
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38. Novel, compact electrochemical and impedance instrumentation.
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Tran Nhu, Chi, Vu Quoc, Tuan, Do Quang, Loc, Nguyen Dang, Phu, Nguyen Hong, Son, Chu Duc, Trinh, and Bui Thanh, Tung
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ANALOG integrated circuits , *RC circuits , *HIGH performance computing , *IMPEDANCE spectroscopy , *ELECTRIC impedance - Abstract
This paper presents the development of a novel, compact electrochemical and impedance instrumentation utilizing an analog integrated circuit (IC) for biosensing applications. Given the increasing availability of multifunctional integrated circuits (ICs), there is a growing need for devices capable of versatile applications spanning multiple fields. To address this requirement, a design was tailored to accommodate multifunctional techniques for biosensing. By combining multi-layer printed circuit board (PCB) techniques with 3D printing, the module was compact and capable of cyclic voltammetry (CV) and electrical impedance spectroscopy (EIS) measurements. Additionally, a comparison was conducted between the CV functionality of a commercial and the customized module. The results demonstrated that the customized module outperformed the commercial module. The Bode and Nyquist plots obtained from the EIS measurements accurately depicted the impedance values of resistance (R) and capacitance (C) in basic RC circuits. The experimental results show the error of R was below 2% and C was below 4% across the full frequency range from 500 Hz to 10 kHz. Furthermore, the high performance of this system was demonstrated by its successful application in monitoring the ripeness of bananas through EIS measurements. These measurements specified the total impedance and phase to assess the ripening stages accurately. This suggests the potential of the proposed system for utilizing impedance measurements in controlling fruit quality. Based on the achieved results, the proposed system holds promise for various electrochemical research and monitoring applications, particularly for electrochemical sensors and biosensors. [ABSTRACT FROM AUTHOR]
- Published
- 2025
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39. Compared to dual-energy X-ray absorptiometry, bioelectrical impedance effectively monitors longitudinal changes in body composition in children and adolescents with obesity during a lifestyle intervention.
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Benjaminsen, Camilla Raaby, Jørgensen, Rasmus Møller, Vestergaard, Esben Thyssen, and Bruun, Jens Meldgaard
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PHOTON absorptiometry , *STATISTICAL correlation , *BEHAVIOR modification , *BODY mass index , *BODY composition , *BIOELECTRIC impedance , *DESCRIPTIVE statistics , *HEALTH behavior , *RESEARCH , *CHILDHOOD obesity , *COMPARATIVE studies , *CONFIDENCE intervals - Abstract
• Bioimpedance (BIA) may be an alternative to dual-energy X-ray absorptiometry (DXA). • BIA reliably tracks longitudinal body composition changes at pediatric group level. • BIA may supplement DXA in pediatric obesity research. • BIA is less accurate than DXA for individual measures of fat mass and fat-free mass. Accurate and efficient body composition assessment is essential for diagnosing and monitoring childhood obesity in clinical and research settings. This study evaluated the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in assessing body composition and its changes during a long-term lifestyle intervention in children and adolescents with obesity. We hypothesized that BIA is comparable to DXA in tracking longitudinal changes in body composition in this population. The study included 92 children and adolescents 5 to 17 years of age (mean 10.5 ± 2.9 years) classified as obese at the time of measurement (body mass index-standard deviation score ≥ 2 SD). From January 1, 2014, to December 31, 2017, they participated in a lifestyle intervention at Randers Regional Hospital. Body composition was assessed using BIA and DXA at baseline and follow-up (mean 20.5 ± 9.3 months). Bland–Altman plots, correlation- and concordance analyses were used to evaluate the agreement between methods. Bland–Altman plots demonstrated wide limits of agreement without significant bias for longitudinal changes in fat mass (FM), FM%, fat-free mass (FFM), and FFM% (0.39 kg (CI –0.14, 0.93), –0.39% (CI –1.06, 0.26), –0.21 kg (CI –0.73, 0.31), and 0.39% (CI –0.27, 1.05), respectively). Correlations between methods for changes in FM, FM%, FFM, and FFM% were 0.93, 0.83, 0.88, and 0.83, respectively. In cross-sectional assessments, BIA underestimated FM and FM% and overestimated FFM and FFM% compared to DXA. Conclusively, BIA effectively monitors longitudinal changes in body composition at a group level in a pediatric population with obesity. However, caution is needed for individual assessments. The study evaluated the agreement between BIA and DXA for assessing body composition and its changes during a long-term lifestyle intervention in children and adolescents with obesity. While BIA proved reliable for tracking longitudinal changes in body composition at a group level, BIA tended to underestimate FM and FM% and overestimate FFM and FFM% in cross-sectional assessments. BIA, Bioelectrical impedance analysis; DXA, Dual-energy X-ray absorptiometry; FFM, Fat-free mass; FM, Fat mass. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2025
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40. Baseline Impedance via Manometry Predicts Pathological Mean Nocturnal Baseline Impedance in Isolated Laryngopharyngeal Reflux Symptoms.
- Author
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Yen-Ching Wang, Chen-Chi Wang, Chun-Yi Chuang, Yung-An Tsou, Yen-Chun Peng, Chi-Sen Chang, and Han-Chung Lien
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RECEIVER operating characteristic curves , *BARRETT'S esophagus , *ELECTRIC impedance , *ESOPHAGOGASTRIC junction , *PROTON pump inhibitors - Abstract
Background/Aims Distal mean nocturnal baseline impedance (MNBI) measuring via pH-impedance may be valuable in diagnosing patients with suspected laryngopharyngeal reflux (LPR). However, its wide adoption is hindered by cost and invasiveness. This study investigates whether baseline impedance measured during high-resolution impedance manometry (HRIM-BI) can predict pathological MNBI. Methods A cross-sectional study in Taiwan included 74 subjects suspected of LPR, who underwent HRIM (MMS) and pH-impedance testing (Diversatek), after stopping proton pump inhibitors for more than 7 days. Subjects with grade C or D esophagitis or Barrett's esophagus were excluded. The cohort was divided into 2 groups: those with concomitant typical reflux symptoms (CTRS, n = 28) and those with isolated LPR symptoms (ILPRS, n = 46). HRIM-BI measurements focused on both distal and proximal esophagi. Pathological MNBI was identified as values below 2065 Ω, measured 3 cm above the lower esophageal sphincter. Results In all subjects, distal HRIM-BI values correlated weakly with distal MNBI(r = 0.34-0.39, P < 0.005). However, in patients with ILPRS, distal HRIM-BI corelated moderately with distal MNBI(r = 0.43-0.48, P < 0.005). The areas under the receiver operating characteristic curve was 0.78 (P = 0.001) with a sensitivity of 0.83 and a specificity of 0.68. No correlation exists between distal HRIM-BI and distal MNBI in patients with CTRS, and between proximal HRIM-BI and proximal MNBI in both groups. Conclusions Distal HRIM-BI from HRIM may potentially predict pathological MNBI in patients with ILPRS, but not in those with CTRS. Future outcome studies linked to the metric are warranted. [ABSTRACT FROM AUTHOR]
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- 2025
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41. Ultrasonographic Evaluation of Systemic Venous Congestion in Maintenance Hemodialysis Patients during Fluid Removal.
- Author
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Gudiño-Bravo, Pedro, Posada-Martinez, Edith L., Cano-Nieto, Mariana M., Ibarra-Marquez, Nikein D., Leal-Escobar, Gabriela, Madero, Magdalena, Rodriguez-Iturbe, Bernardo, Ivey-Miranda, Juan B., and Lopez-Gil, Salvador
- Subjects
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CENTRAL venous pressure , *HYPEREMIA , *VENA cava inferior , *BIOELECTRIC impedance , *HEPATIC veins - Abstract
Introduction: Fluid overload is a frequent and serious complication in hemodialysis patients. The combination of multiple point-of-care ultrasound (POCUS) measurements can identify significant venous congestion, but its usefulness to determine ultrafiltration (UF) requirements and dry weight is unknown. Therefore, we evaluated prospectively patients in maintenance hemodialysis to establish the correlations between changes in venous congestion parameters and fluid removal. Methods: This was a prospective, single-center, observational study. POCUS venous congestion measurements were performed in 22 patients during 32 online post-dilutional hemodiafiltration sessions, and findings were correlated with UF volume, central venous pressure, and body water composition determined by multifrequency bioelectric impedance analysis (BIA). Results: The pre-dialysis weight was on average 1.9 kg above the BIA estimated dry weight, the average initial inferior vena cava (IVC) diameter was <2 cm. An initial abnormal hepatic vein (HV) waveform was present in 26% (8) of the measurements. The average UF volume was 2,084 ± 655 mL and correlated with changes in IVC diameter (R = 0.34, 95% CI: [0.18, 0.56], p < 0.05) but not with any other POCUS venous congestion parameters. Normalization of the IVC diameter and HV waveform was observed during the first UF hour in all initially altered measurements. Diameter reduction in the IVC correlated with total body water volume reduction estimated with BIA when measured immediately after fluid removal (R = 0.34, 95% CI: [0.08, 0.56], p < 0.05). Conclusion: Reduction in IVC diameter had a modest but significant correlation with UF volume in our patients on maintenance hemodiafiltration. POCUS may be used to monitor patients during UF. [ABSTRACT FROM AUTHOR]
- Published
- 2025
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- View/download PDF
42. Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells.
- Author
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Wang, Shih-Min, Lu, Mei-Chin, Hsu, Yu-Ming, Huang, Chun-Chung, Fang, Chih-Yuan, Yu, Chuan-Hang, Chueh, Pin Ju, Yu, Cheng-Chia, and Lee, Shiao-Pieng
- Subjects
ALCYONACEA ,ELECTRIC impedance ,SQUAMOUS cell carcinoma ,CELL survival ,CANCER cells - Abstract
The extract of the soft coral Lobophytum crassum has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of L. crassum (C127) on the OSCC cells. This study evaluated the effects of the soft coral extract of L. crassum (C127) on SAS and Ca9-22 cells, cell viability, migration ability, and apoptosis. Electric cell-substrate impedance sensing (ECIS) was parallelly used on SAS cells to confirm the results. C127 affected cell viability, morphology, and migration ability in both cell lines. In SAS cells, C127 inhibited cell viability in a dose dependent manner (P < 0.001) and induced apoptosis at 10 μg/mL (P < 0.05). In addition, C127 significantly inhibited migration ability on both cell lines in a dose-dependent manner (P < 0.001). This study illustrated the potential of marine-derived compounds of L. crassum on its activity against OSCC cells. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
43. Fat loss and muscle gain: The possible role of striatal dopaminergic tone in determining the efficacy of physical exercise.
- Author
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Abdullah, Muhammad, Lin, Shih-Hsien, Huang, Li-Chung, Chiu, Nan-Tsing, and Yang, Yen Kuang
- Subjects
SINGLE-photon emission computed tomography ,MUSCLE mass ,BODY composition ,ADIPOSE tissues ,BIOELECTRIC impedance - Abstract
The effectiveness of exercise for obesity is contentious due to individual response variability. Owing to the roles of dopamine in motor functions, metabolism, and appetite, this study aimed to identify striatal dopamine as a predictor of variability in exercise response, specifically in terms of fat loss and muscle gain. Healthy non-exercising males completed an 8-week program, exercising 1 h, 4 days a week. Striatal dopaminergic tone was assessed by measuring dopamine transporter availability using technetium-99 m labelled tropane derivative, [99mTc]TRODAT-1 (TRODAT), single-photon emission computed tomography, and body composition (fat and muscles mass) was analysed using bioelectrical impedance. Lower baseline dopamine levels were associated with greater fat mass loss (r = 0.58, p = 0.006), percentage fat mass loss (r = 0.53, p = 0.013), and increase in muscle mass (β = -0.53, p = 0.035, after taking age and smoking status as covariates). These findings enhance our understanding of obesity neurobiology and exercise response variability, necessitating further research for targeted interventions based on dopaminergic profiles. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
44. A correlational study of bioimpedance signals from the left and right limbs in assessment of arterial stiffness.
- Author
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Khammud, A. M., Latypova, A. A., Tangatarova, S. V., Chibizov, P. E., Briko, A. N., Tikhomirov, A. N., Shchukin, S. I., Mukhanova, S. É., and Safronova, T. A.
- Subjects
PHYSIOLOGY of the anatomical extremities ,RISK assessment ,STATISTICAL correlation ,PEARSON correlation (Statistics) ,ARTERIAL diseases ,BIOELECTRIC impedance ,CARDIOVASCULAR diseases risk factors ,DESCRIPTIVE statistics ,BIOMEDICAL engineering ,RESEARCH ,PULSE wave analysis ,COMPARATIVE studies - Abstract
We report here an evaluation of the effectiveness of multichannel bioimpedance devices for measuring pulse wave velocity as an indicator of arterial stiffness, an important factor in assessing cardiovascular risk. The study used the REO-32 multichannel electrical impedance system and the Vasera VS-1500 sphygmometer to compare pulse wave velocity measurements in different limb segments. The results demonstrated a high correlation between these instruments, particularly in lower limb measurements. The study highlights the potential of bioimpedance technology to provide detailed and timely data across different body segments, improving prognostic opportunities for the diagnosis of cardiovascular health. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
45. Modeling and Characterization of Multilayer Piezoelectric Stacks via Dynamic Stiffness Method.
- Author
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Ding, Wenxiang, Liang, Zhaofeng, Zhao, Wei, Zhong, Hongmei, Chen, Dan, Bavencoffe, Maxime, and Lethiecq, Marc
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DYNAMIC stiffness ,FINITE element method ,MODE shapes ,ELECTRIC impedance ,EQUATIONS of motion - Abstract
Multilayer piezoelectric stacks, which are multiple layers of piezoelectric materials placed on top of each other, are widely used to achieve precise linear movement and high-force generation. In this paper, a dynamic stiffness (DS) method for the dynamic vibration analysis of multilayer piezoelectric stacks is presented. First, the general solutions for all physical quantities of the three vibration contributions (i.e., pure vibration, symmetrically coupled vibration, and anti-symmetrically coupled vibration) are derived from the governing equations of motion. Then, the DS matrices of each layer of the piezoelectric stack are obtained, and they are assembled to form a global DS matrix. The electrical impedances and the mode shapes of a piezoelectric stack consisting of two piezoelectric disks connected in series and in parallel are calculated using our method as well as by the finite element method. The comparison shows good agreement. Finally, the effect of the number of layers on the dynamic responses of piezoelectric stacks is investigated. The DS method developed here provides an efficient and accurate analytical tool for the parametric and optimization analysis of the coupled vibrations of multilayer piezoelectric structures. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
46. Exploring Electrolyte-Induced Phenomena in Graphene Nanoplatelet-Based Electrodes.
- Author
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Oneeb, Muhammad, Iqbal, Javed, Mumtaz, Asifa, Ameen, Muhammad, Noor, Marhaba, Nawaz, Hamza, Ali, Haider, and Jansher, M. Usama
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ELECTRIC impedance ,ENERGY density ,AQUEOUS electrolytes ,ELECTRIC conductivity ,POWER density ,SUPERCAPACITORS - Abstract
Graphene has a large surface area, an open interconnect structure, and superior electrical conductivity, making it a promising material for high-performance supercapacitors. The appropriate choice of aqueous electrolyte is essential for its application as an electrode in a supercapacitor. The present study explores the supercapacitive behavior of graphene nanoplatelets in aqueous electrolytes that are acidic (H
2 SO4 ), alkaline (NaOH), and neutral (Na2 SO4 ). Among these, H2 SO4 delivers the maximum capacitance of 292 F/g, followed by NaOH and Na2 SO4 , with specific capacitance of 276 F g−1 and 240 F g−1 , respectively, from cyclic charge–discharge at a current density of 0.3 A g-1 . Additionally, this electrode has maximum energy density and power density of 28 Wh kg−1 and 270 W kg−1 , and it retains 90% of its capacity over 5000 cycles in H2 SO4 electrolytes. An in-depth examination of supercapacitance is provided, along with an equivalent circuit simulation to deduce the behavior of the electrode–electrolyte interface. [ABSTRACT FROM AUTHOR]- Published
- 2025
- Full Text
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47. Effect of Oral Nutritional Supplements Composed of High Protein on Body Weight Loss After Gastrectomy.
- Author
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SATORU KIKUCHI, NOBUO TAKATA, YOSHIHIKO KAKIUCHI, SHINJI KURODA, HAJIME KASHIMA, SHUNSUKE TANABE, KAZUHIRO NOMA, AYAKO TAKAHASHI, SHUNSUKE KAGAWA, and TOSHIYOSHI FUJIWARA
- Subjects
DIETARY supplements ,GASTRECTOMY ,WEIGHT loss ,BIOELECTRIC impedance ,BODY weight - Abstract
Background/Aim: Body weight loss (BWL) after gastrectomy for gastric cancer (GC) decreases postoperative quality of life and survival in patients with GC. This study aimed to evaluate the effect of oral nutritional supplements composed of high protein on BWL in the early period following gastrectomy. Patients and Methods: Pre- and postoperative body weight and skeletal muscle mass were measured using bioelectrical impedance analysis in patients undergoing radical gastrectomy for GC and analyzed retrospectively. Patients received either a regular diet (control group, n=43) or 250 ml (320 kcal) per day of a high-protein oral nutritional supplement (ONS) (22 g protein) in addition to their regular diet (ONS group, n=40) for four weeks after gastrectomy. The actual daily intake of ONS was recorded by patients themselves. The BWL and skeletal muscle loss (SML) at one month after surgery were compared between the two groups. Results: BWL and SML at one month after surgery were similar between the two groups. In the ONS group, patients were divided into two subgroups (ONS-H and ONSL) according to whether their ONS intake amount was above or below the average value of 216 kcal. The ONS-H group (ONS intake =216 kcal) showed significantly lower BWL compared to the control group (-4.6±2.6% vs. -6.2±2.5%; p=0.03). Moreover, the ONS group showed significantly lower BWL at one month after surgery than the control group in cases of total or proximal gastrectomy (-5.9±3.0% vs. -7.8±1.9%; p=0.04), although no significant difference was observed between the two groups in distal gastrectomy. The hematological nutritional parameters were similar between the two groups. Conclusion: The administration of ONS composed of high protein for four weeks after gastrectomy did not improve BWL at one month after gastrectomy. However, adequate amount of ONS intake and ONS intake after total or proximal gastrectomy might improve BWL. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
48. Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk.
- Author
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Hertiš Petek, Tjaša, Homšak, Evgenija, Svetej, Mateja, and Marčun Varda, Nataša
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SEX factors in disease ,CHILDHOOD obesity ,PULSE wave analysis ,BIOELECTRIC impedance ,ADIPOSE tissues - Abstract
Background: Systemic inflammation and oxidative stress are fundamental contributors to the onset of conditions related to childhood obesity, such as cardiovascular (CV) diseases. We aimed to assess CV risk in childhood obesity by examining sex differences in adiposity indices, cardiometabolic profiles, inflammation, and oxidative stress biomarkers. We also aimed to assess the potential of the interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11) as a novel biomarker. Methods: Eighty children (36 girls) aged 5–18 years with overweight, obesity, or normal weight were analyzed. Fasting blood samples were obtained to assess C-reactive protein (CRP), leukocytes, myeloperoxidase (MPO), adiponectin, monocyte chemoattractant protein-1, superoxide dismutase-1, I-TAC/CXCL11, and a comprehensive cardiometabolic profile, including glucose, lipid, renal, liver, and thyroid function markers. Adiposity indices were determined using bioelectrical impedance analysis (BIA) and anthropometric measures, including BMI, waist-to-hip and waist-to-height ratios, and visceral and subcutaneous fat thickness. Blood pressure (BP) and pulse wave velocity were also evaluated. Results: Girls had less central obesity and fewer CV risk factors than boys, despite having similar total fat mass. Both girls and boys with overweight or obesity showed higher CRP levels. Girls with excess weight had increased leukocyte counts, while boys had elevated MPO levels, which correlated positively with adiposity indices, systolic BP, and homocysteine, and negatively with HDL. I-TAC/CXCL11 levels were similar across groups. Conclusions: Adiposity indices are essential for evaluating CV risk in children and adolescents, with sex differences underscoring the need for tailored approaches. MPO correlated significantly with CV risk markers, supporting its inclusion in routine assessments. I-TAC/CXCL11 warrants further study in childhood obesity. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
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49. Comparatively Evaluation of the Methods Used in the Assessment of Health and Impairment of Body Composition.
- Author
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Ayyildiz, Sukru Ahmet, Yagiz, Suleyman, Algul, Sermin, and Ozcelik, Oguz
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BODY composition ,ADIPOSE tissues ,WAIST-hip ratio ,BODY mass index ,BIOELECTRIC impedance - Abstract
Introduction: Assessment of body composition is an important way that reveal valuable information about the health status of individuals. To evaluate the effectiveness of the methods, the body compositions of young male and female students were compa ratively evaluated using the bioelectrical impedance method (BIA), body mass index (BMI), and waist -hip ratio (WHR). Materials and Methods: A total of 226 (n= 112 males and n= 114 females) young students participated in this study. Body composition analyses were performed using BIA, BMI, and WHR. Results: Considering the whole data, a statistically significant correlation between BMI and BIA was observed. However, there is a difference in risk groups with low and normal values that may result in the differences between the cut-off points determined by ethnicity and gender. Conclusion: In general, although anthropometric measurements have provided meaningful results for population evaluation, technological evaluations should be taken into account in measurements in decision-making situations related to the health status of individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
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50. Body Composition in Preterm Infants: Current Insights and Emerging Perspectives.
- Author
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Viswanathan, Sreekanth, Thoene, Melissa, Alja'nini, Zaineh, Alur, Pradeep, and McNelis, Kera
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INFANTS ,PLETHYSMOGRAPHY ,PHOTON absorptiometry ,INFANT development ,BODY mass index ,BODY composition ,BODY weight ,NEURAL development ,NUTRITIONAL requirements ,BIOELECTRIC impedance ,MAGNETIC resonance imaging ,ULTRASONIC imaging ,INFANT nutrition ,ANTHROPOMETRY ,EVALUATION ,CHILDREN - Abstract
In recent years, significant advancements in respiratory and nutritional care have markedly improved the survival rates of preterm infants and enhanced long-term health outcomes. Despite these improvements, emerging research highlights the lasting impacts of early growth patterns on an individual's health trajectory. Adults born prematurely face a higher incidence of health issues related to their early birth. The American Academy of Pediatrics recommends that preterm infants should achieve growth rates similar to those of fetuses, with clinicians emphasizing nutrition delivery to help these infants reach their expected weight for gestational age. However, this approach often results in altered body composition, characterized by increased fat mass and decreased fat-free mass compared to full-term infants. Air displacement plethysmography stands out as a highly reliable method for measuring preterm body composition, while DEXA scans, despite their reliability, tend to overestimate body fat. Other methods include bioelectric impedance, isotope dilution, MRI, ultrasound, and skinfold thickness, each with its own strengths and limitations. In this paper, we aim to raise awareness among neonatal clinicians about the importance of achieving acceptable neonatal body composition. We discuss the pros and cons of different body composition measurement methods, the impact of nutrition and other factors on body composition in preterm infants, long-term follow-up data, and the potential use of body composition data to tailor nutritional interventions in NICU and post-discharge settings. This comprehensive approach is designed to optimize health outcomes for preterm newborns by focusing on their body composition from an early stage. [ABSTRACT FROM AUTHOR]
- Published
- 2025
- Full Text
- View/download PDF
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