776 results on '"Xiaoxia, Wu"'
Search Results
2. Value of unenhanced CT combined with clinical features in predicting adnexal torsion in women
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Xiaowen GU, Lu JIANG, Lei CUI, Xiaoxia WU, Jibin ZHANG, and Ying FEI
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adnexal torsion ,unenhanced ct examination ,navel sign ,whirl sign ,Medicine - Abstract
ObjectiveTo investigate the value of unenhanced CT combined with clinical features in predicting adnexal torsion in women with abdominal pain and an adnexal mass. MethodsA retrospective selection of patients with abdominal pain and an adnexal mass underwent operation in 2 tertiary hospitals from January 2018 to September 2023. The torsion group (n=53) and non-torsion group (n=53) were matched in a 1∶1 ratio. 15 CT signs of adnexal masses were reviewed independently by two radiologists using a double-blind method. The high-risk factors were screened using multivariate logistic regression analysis. The diagnostic values of high-risk factors for adnexal torsion were assessed using receiver operating characteristic (ROC) curves.ResultsAccording to the surgical and pathological results, the most common adnexal mass in torsion group was mature cystic teratoma (32.1%), and the most common mass in the non-torsion group was adnexal abscess (20.8%). The age, fever rate, white blood cell count, location of mass, thickened fallopian tube rate, and pelvic effusion rate were not statistically different between the two groups, the nausea and vomiting and remaining CT signs were significant different between the two groups (P<0.05). Multivariate logistic analysis showed that nausea and vomiting (OR=4.886), navel sign (OR=22.733), and whirl sign (OR=43.462) were independently associated with adnexal torsion (P<0.05). The area under the curve (AUC) of nausea and vomiting, navel sign, and whirl sign were 0.717, 0.802, and 0.840, respectively; AUC of the combination of all three was 0.877 with 92.45% of sensitivity, 84.91% of specificity, 85.96% of positive predictive value, 91.84% of negative predictive value, and 88.68% of accuracy. ConclusionsFor women with abdominal pain and an adnexal mass, nausea and vomiting, navel sign, and whirl sign are help of predicting adnexal torsion, and combination value of all three is best.
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- 2024
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3. Mechanism of biliary atresia caused by T follicular helper cells-induced immune injury
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Ze Ji, Xiaoxia Wu, Hongxia Ren, and Jiexiong Feng
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Biliary atresia ,Pathogenesis ,T follicular helper cell ,Immune injury ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Biliary atresia (BA) has diverse and unclear pathogenesis, which may be related to immune response in response to a foreign stimulus. T follicular helper (Tfh) cells have been found to play an important role in various immune diseases. Aims To investigate the expression of Tfh cells in BA and non-BA cholestatic diseases in children. Methods Transcriptome sequencing and Gene Ontology (GO) enrichment analysis were performed to investigate the differences in gene expression between the BA group and the non-BA cholestasis group. Study the distribution of Tfh cells in liver tissues of the BA and non-BA cholestatic groups through single sample gene set enrichment analysis (ssGSEA). Tfh cells (CD3+Bcl6+) in liver tissues from BA patients were labeled by double immunofluorescent staining to verify their distribution in the liver. Results Transcriptome sequencing showed differences in gene expression between the BA group and the non-BA cholestasis group. A total of 808 genes were up-regulated and 405 genes were down-regulated in BA, suggesting that there might be a specific immune response in BA. GO enrichment analysis showed that BA group had augmented response to foreign stimulus and increased metabolic process compared to the non-BA cholestatic group. The relative proportion of immune cells was analyzed by ssGSEA method. The proportions of Tfh cells, activated B cells, CD4+ T cells, memory B cells and Th2 cells were higher in the BA group than in the non-BA cholestatic group. Fluorescence immunostaining showed that Tfh cells were significantly increased in liver tissue samples of the BA group compared to the non-BA cholestasis group, which was consistent with the transcriptome sequencing results. Conclusion Tfh cells share in immune cascade involvement in BA. Our work support immune pathogenesis of the in response to a stimulus that might be foreign in BA.
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- 2024
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4. Wild rodents seed choice is relevant for sustainable agriculture
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Yang Peng, Zhenbang Hu, Wen Dong, Xiaodong Wu, Chunyan Liu, Rongsheng Zhu, Jinhui Wang, Mingliang Yang, Zhaoming Qi, Ying Zhao, Jianan Zou, Xiaoxia Wu, Yingdong Bi, Limin Hu, Pascal Ratet, Qingshan Chen, and Dawei Xin
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Medicine ,Science - Abstract
Abstract Mitigating pre-harvest sprouting (PHS) and post-harvest food loss (PHFL) is essential for enhancing food securrity. To reduce food loss, the use of plant derived specialized metabolites can represent a good approach to develop a more eco-friendly agriculture. Here, we have discovered that soybean seeds hidden underground during winter by Tscherskia triton and Apodemus agrarius during winter possess a higher concentration of volatile organic compounds (VOCs) compared to those remaining exposed in fields. This selection by rodents suggests that among the identified volatiles, 3-FurAldehyde (Fur) and (E)-2-Heptenal (eHep) effectively inhibit the growth of plant pathogens such as Aspergillus flavus, Alternaria alternata, Fusarium solani and Pseudomonas syringae. Additionally, compounds such as Camphene (Cam), 3-FurAldehyde, and (E)-2-Heptenal, suppress the germination of seeds in crops including soybean, rice, maize, and wheat. Importantly, some of these VOCs also prevent rice seeds from pre-harvest sprouting. Consequently, our findings offer straightforward and practical approaches to seed protection and the reduction of PHS and PHFL, indicating potential new pathways for breeding, and reducing both PHS and pesticide usage in agriculture.
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- 2024
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5. The type III effector NopL interacts with GmREM1a and GmNFR5 to promote symbiosis in soybean
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Chao Ma, Jinhui Wang, Yongkang Gao, Xulun Dong, Haojie Feng, Mingliang Yang, Yanyu Yu, Chunyan Liu, Xiaoxia Wu, Zhaoming Qi, Luis A. J. Mur, Kévin Magne, Jianan Zou, Zhenbang Hu, Zhixi Tian, Chao Su, Pascal Ratet, Qingshan Chen, and Dawei Xin
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Science - Abstract
Abstract The establishment of symbiotic interactions between leguminous plants and rhizobia requires complex cellular programming activated by Rhizobium Nod factors (NFs) as well as type III effector (T3E)-mediated symbiotic signaling. However, the mechanisms by which different signals jointly affect symbiosis are still unclear. Here we describe the mechanisms mediating the cross-talk between the broad host range rhizobia Sinorhizobium fredii HH103 T3E Nodulation Outer Protein L (NopL) effector and NF signaling in soybean. NopL physically interacts with the Glycine max Remorin 1a (GmREM1a) and the NFs receptor NFR5 (GmNFR5) and promotes GmNFR5 recruitment by GmREM1a. Furthermore, NopL and NF influence the expression of GmRINRK1, a receptor-like kinase (LRR-RLK) ortholog of the Lotus RINRK1, that mediates NF signaling. Taken together, our work indicates that S. fredii NopL can interact with the NF signaling cascade components to promote the symbiotic interaction in soybean.
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- 2024
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6. Evaluation of Flavonoid Components in Chinese Olive by Integrated Use of Metabolomics and Network Pharmacology
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LAI Ruilian, SHEN Chaogui, LONG Yu, LIN Yanjuan, WEI Xiaoxia, WU Rujian
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chinese olive ,germplasm resource ,metabolomics ,network pharmacology ,flavonoids ,Food processing and manufacture ,TP368-456 - Abstract
Objective: To explore the potential biological activity of flavonoid components in Chinese olive (Canarium album Raeusch.), and the differences in flavonoid components among different germplasm resources of Chinese olive. Methods: The bioactive flavonoid components were identified using network pharmacology and molecular docking analysis, and the accumulation levels of flavonoid components in the germplasm resources were studied by metabolomics. Results: A total of 44 flavonoid components were identified, and 18 potential bioactive flavonoids and 180 targets for them were selected through the TCMSP database, drug-likeness and oral bioavailability. Luteolin, quercetin, catechin and epicatechin were found to be important components that could potentially affect the pharmacological activity of Chinese olive. The 35 key targets identified based on the connectivity between flavonoid components and their targets were enriched in 348 Gene Ontology (GO) terms and 136 Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathways, involving pharmacological activities such as anticancer, antiviral, antibacterial, and anti-inflammatory function, blood glucose regulation, and liver protection. Through molecular docking and visual analysis, stable combinations between the selected bioactive flavonoid components of Chinese olive and the key targets were found. Conclusion: The integration of metabolomics and network pharmacology can provide a scientific basis for exploring the medicinal value of Chinese olive. Flavonoids of Chinese olive exert various pharmacological activities through a multi-component, multi-target, and multi-pathway mechanism.
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- 2024
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7. Quant-LLM: Accelerating the Serving of Large Language Models via FP6-Centric Algorithm-System Co-Design on Modern GPUs.
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Haojun Xia, Zhen Zheng, Xiaoxia Wu, Shiyang Chen, Zhewei Yao, Stephen Youn, Arash Bakhtiari, Michael Wyatt, Donglin Zhuang, Zhongzhu Zhou, Olatunji Ruwase, Yuxiong He, and Shuaiwen Leon Song
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- 2024
8. Exploring Post-training Quantization in LLMs from Comprehensive Study to Low Rank Compensation.
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Zhewei Yao, Xiaoxia Wu, Cheng Li 0001, Stephen Youn, and Yuxiong He
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- 2024
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9. DeepSpeed Data Efficiency: Improving Deep Learning Model Quality and Training Efficiency via Efficient Data Sampling and Routing.
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Conglong Li, Zhewei Yao, Xiaoxia Wu, Minjia Zhang, Connor Holmes, Cheng Li 0001, and Yuxiong He
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- 2024
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10. A novel molecular classification system based on the molecular feature score identifies patients sensitive to immune therapy and target therapy
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Yang Li, Yinan Ding, Jinghao Wang, Xiaoxia Wu, Dinghu Zhang, Han Zhou, Pengfei Zhang, and Guoliang Shao
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hepatocellular carcinoma ,precision medicine ,molecular classifications ,prognostic nomogram ,multidimensional feature scores ,immune therapy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundHepatocellular carcinoma (HCC) is heterogeneous and refractory with multidimensional features. This study aims to investigate its molecular classifications based on multidimensional molecular features scores (FSs) and support classification-guided precision medicine.MethodsData of bulk RNA sequencing, single nucleotide variation, and single-cell RNA sequencing were collected. Feature scores (FSs) from hallmark pathways, regulatory cell death pathways, metabolism pathways, stemness index, immune scores, estimate scores, etc. were evaluated and screened. Then, the unsupervised clustering on the core FSs was performed and the characteristics of the resulting clusters were identified. Subsequently, machine learning algorithms were used to predict the classifications and prognoses. Additionally, the sensitivity to immune therapy and biological roles of classification-related prognostic genes were also evaluated.ResultsWe identified four clusters with distinct characteristics. C1 is characterized by high TP53 mutations, immune suppression, and metabolic downregulation, with notable responsiveness to anti-PD1 therapy. C2 exhibited high tumor purity and metabolic activity, moderate TP53 mutations, and cold immunity. C3 represented an early phase with the most favorable prognosis, lower stemness and tumor mutations, upregulated stroma, and hypermetabolism. C4 represented a late phase with the poorest prognosis, highest stemness, higher TP53 mutations, cold immunity, and metabolic downregulation. We further developed practical software for prediction with good performance in the external validation. Additionally, FTCD was identified as a classification-specific prognostic gene with tumor-suppressing role and potential as a therapeutic target, particularly for C1 and C4 patients.ConclusionsThe four-layer classification scheme enhances the understanding of HCC heterogeneity, and we also provide robust predictive software for predicting classifications and prognoses. Notably, C1 is more sensitive to anti-PD1 therapies and FTCD is a promising therapeutic target, particularly for C1 and C4. These findings provide new insights into classification-guided precision medicine.
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- 2024
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11. Application of Whole‐Exome Sequencing in the Prenatal Diagnosis of Foetuses With Central Nervous System Abnormalities
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Caiqun Luo, Erya Wen, Yang Liu, Hui Wang, Bei Jia, Liyuan Chen, Xiaoxia Wu, Qian Geng, Huaxuan Wen, Shengli Li, Bingguang Liu, Weiqing Wu, and Mei Zhong
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central nervous system abnormalities ,foetus ,prenatal diagnosis ,whole‐exome sequencing ,Genetics ,QH426-470 - Abstract
ABSTRACT Objective To investigate the clinical value of whole‐exome sequencing (WES) in the diagnosis of foetuses with central nervous system (CNS) abnormalities but having a normal karyotyping and chromosomal microarray result. Method During the period of 2016–2022, there were a total of 149 foetuses with CNS abnormalities but having negative karyotyping and chromosomal microarray analysis results; WES was performed on these foetuses and their parents. Variants were classified according to ACMG guidelines, and the association of pathogenic variants with specific types of CNS abnormalities was explored. Results Among these 149 foetuses, three categories of abnormalities, namely, single CNS abnormality, multiple CNS abnormalities, CNS abnormalities along with other organ system abnormalities were identified, for which the detection rate of P/LP variants is 17.4% (12/69), 28.6% (14/49) and 54.8% (17/31), respectively. Conclusion WES brought about an increase of 28.9% in diagnostic yield in the prenatal evaluation of foetuses with CNS abnormalities but having negative karyotyping and chromosome array results. WES may also be of benefit for the diagnosis of foetuses with isolated CNS abnormalities, as well as for making more informed interpretations of imaging findings and for providing better genetic counselling.
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- 2024
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12. The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute lymphoblastic leukemia
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Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, and Miao Miao
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Blinatumomab ,Philadelphia chromosome–like acute lymphoblastic leukemia ,Philadelphia chromosome‐positive acute lymphoblastic leukemia ,tyrosine kinase inhibitor ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Tyrosine kinase inhibitors (TKIs) have revolutionized Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) treatment. The combination of blinatumomab and a TKI in the frontline setting has shown the safety and efficacy of the chemotherapy‐free treatment approach in patients with Ph + ALL. This retrospective analysis included 19 patients with Ph + ALL and Ph‐like ALL treated with the combination of blinatumomab and a TKI. Of the 14 newly diagnosed patients, the overall response, complete remission (CR), and molecular response (CMR) rates after one cycle of blinatumomab were 100% (10/10), 90% (9/10), and 57% (8/14), respectively. Of the five relapsed patients, the CR and CMR rates were 50% (2/4) and 40% (2/5). Blinatumomab in combination with TKIs is safe and effective and hence this combination therapy could be a viable therapeutic option in front‐line treatment of patients with Ph + ALL.
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- 2024
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13. Perioperative/postoperative anxiety and its interventions in gynecological cancers: a comprehensive review of clinical evidence
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Beibei Chen, Chunyan Chen, Xiumin Zhao, and Xiaoxia Wu
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gynecological cancers ,anxiety ,perioperative ,postoperative ,nursing intervention ,Psychiatry ,RC435-571 - Abstract
Gynecological cancers are prevalent malignancies among females, and surgical intervention is the primary therapeutic approach offering the possibility of a definitive cure. Recent research has highlighted the susceptibility of gynecological cancer patients to experiencing anxiety symptoms during the perioperative and postoperative phases, with this psychological condition being linked to suboptimal recovery following surgery. Nevertheless, certain interventions have shown promise in mitigating perioperative and postoperative anxiety in gynecological cancer patients. In this study, we conducted a comprehensive review to collect the existing evidence on this subject. Through a systematic search across six common databases, we screened and included 28 pertinent studies. The current review emphasizes the elevated occurrence of perioperative and postoperative anxiety among patients with gynecological cancers (i.e., uterine, cervical, ovarian, endometrial, and vulval cancers). Specific nursing interventions (i.e., crisis intervention nursing, multidisciplinary collaborative continuous nursing, psychological nursing, comprehensive psychological nursing, reminiscence therapy involved care, cognitive behavioral stress management, hospital-family integrated continuation nursing, high-quality nursing care, relaxation-focused nursing program, and relaxation/counseling intervention) and psychotropic medications may serve as dependable approaches to mitigate perioperative and postoperative anxiety. This study represents a novel contribution to the literature by providing a characterization of perioperative and postoperative anxiety in the context of gynecological oncology. The findings underscore the significance of addressing perioperative and postoperative anxiety as a critical clinical concern for individuals with gynecological cancers, emphasizing the need for further research to develop effective interventions.
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- 2024
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14. ZeRO++: Extremely Efficient Collective Communication for Large Model Training.
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Guanhua Wang, Heyang Qin, Sam Ade Jacobs, Xiaoxia Wu, Connor Holmes, Zhewei Yao, Samyam Rajbhandari, Olatunji Ruwase, Feng Yan 0001, Lei Yang 0001, and Yuxiong He
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- 2024
15. Understanding Int4 Quantization for Language Models: Latency Speedup, Composability, and Failure Cases.
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Xiaoxia Wu, Cheng Li 0001, Reza Yazdani Aminabadi, Zhewei Yao, and Yuxiong He
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- 2023
16. Mojito: Motion Trajectory and Intensity Control for Video Generation.
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Xuehai He, Shuohang Wang, Jianwei Yang, Xiaoxia Wu, Yiping Wang, Kuan Wang, Zheng Zhan, Olatunji Ruwase, Yelong Shen, and Xin Eric Wang
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- 2024
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17. GRIN: GRadient-INformed MoE.
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Liyuan Liu, Young Jin Kim 0001, Shuohang Wang, Chen Liang 0006, Yelong Shen, Hao Cheng 0002, Xiaodong Liu 0003, Masahiro Tanaka, Xiaoxia Wu, Wenxiang Hu, Vishrav Chaudhary, Zeqi Lin, Chengruidong Zhang, Jilong Xue, Hany Awadalla, Jianfeng Gao 0001, and Weizhu Chen
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- 2024
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18. Found in the Middle: How Language Models Use Long Contexts Better via Plug-and-Play Positional Encoding.
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Zhenyu Zhang 0015, Runjin Chen, Shiwei Liu 0003, Zhewei Yao, Olatunji Ruwase, Beidi Chen, Xiaoxia Wu, and Zhangyang Wang
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- 2024
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19. FP6-LLM: Efficiently Serving Large Language Models Through FP6-Centric Algorithm-System Co-Design.
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Haojun Xia, Zhen Zheng, Xiaoxia Wu, Shiyang Chen, Zhewei Yao, Stephen Youn, Arash Bakhtiari, Michael Wyatt, Donglin Zhuang, Zhongzhu Zhou, Olatunji Ruwase, Yuxiong He, and Shuaiwen Leon Song
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- 2024
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20. Genome-wide analysis of soybean DnaJA-family genes and functional characterization of GmDnaJA6 responses to saline and alkaline stress
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Binshuo Zhang, Zhen Liu, Runnan Zhou, Peng Cheng, Haibo Li, Zhiyang Wang, Ying Liu, Mingyang Li, Zhenqing Zhao, Zhenbang Hu, Qingshan Chen, Xiaoxia Wu, and Ying Zhao
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Soybean ,Heat shock proteins ,DnaJ ,Salt stress ,Alkali stress ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Plant DnaJA proteins act as molecular chaperones in response to environmental stressors. The purpose of this study was to characterize the function and regulatory mechanisms of DnaJA genes in soybean. Gene expression profiles in various soybean tissues at various stages of development indicated that GmDnaJAs function in the coordination of stress and plant hormone responses. GmDnaJA6 was identified as a candidate regulator of saline and alkaline stress resistance and GmDnaJA6 overexpression lines showed increased soybean saline and alkaline tolerance. DnaJ interacted with Hsp70, and GmHsp70 increased the saline and alkaline tolerance of plants with chimeric soybean hairy roots.
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- 2023
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21. High-intensity interval training versus moderate-intensity continuous training on patient quality of life in cardiovascular disease: a systematic review and meta-analysis
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Haohan Yu, Xudong Zhao, Xiaoxia Wu, Jing Yang, Jun Wang, and Lijuan Hou
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Medicine ,Science - Abstract
Abstract This systematic review and meta-analysis aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the quality of life (QOL) and mental health (MH) of patients with cardiovascular disease (CVDs). Web of Science, Medline, Embase, Cochrane (CENTRAL), CINAHL, China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal databases were searched from their date of establishment to July, 2023. A total of 5798 articles were screened, of which 25 were included according to the eligibility criteria. The weighted mean difference (WMD) and standardized mean difference (SMD) were used to analyze data from the same and different indicator categories, respectively. The fixed-effects model (FE) or random-effects model (RE) combined data based on the between-study heterogeneity. There were no statistically significant differences regarding QOL, physical component summary (PCS), mental component summary (MCS), and MH, including depression and anxiety levels, between the HIIT and MICT groups [SMD = 0.21, 95% confidence interval (CI) − 0.18–0.61, Z = 1.06, P = 0.290; SMD = 0.10, 95% CI − 0.03–0.23, Z = 1.52, P = 0.128; SMD = 0.07, 95% CI − 0.05–0.20, Z = 1.13, P = 0.25; SMD = − 0.08, 95% CI − 0.40–0.25, Z = − 0.46, P = 0.646; WMD = 0.14. 95% CI − 0.56–0.84, Z = 0.39, P = 0.694, respectively]. HIIT significantly improved PCS in the coronary artery disease (CAD) population subgroup relative to MICT. HIIT was also significantly superior to MICT for physical role, vitality, and social function. We conclude that HIIT and MICT have similar effects on QOL and MH in patients with CVD, while HIIT is favorable for improving patients’ self-perceived physiological functioning based on their status and social adjustment, and this effect is more significant in patients with CAD.
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- 2023
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22. Mediation effect of maternal triglyceride and fasting glucose level on the relationship between maternal overweight/ obesity and fetal growth: a prospective cohort study
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Yanmei Wan, Yixuan Chen, Xiaoxia Wu, Aiqi Yin, Fuying Tian, Huafan Zhang, Xuna Huang, Linlin Wu, and Jianmin Niu
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Obesity ,Large for gestational age ,Triglyceride ,Fasting plasma glucose ,Mediation analysis ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Previous studies have suggested that maternal overweight/obesity is asscociated with macrosomia. The present study aimed to investigate the mediation effects of fasting plasma glucose (FPG) and maternal triglyceride (mTG) in the relationship between maternal overweight/obesity and large for gestational age (LGA) among non-diabetes pregnant women. Methods This prospective cohort study was conducted in Shenzhen from 2017 to 2021. A total of 19,104 singleton term non-diabetic pregnancies were enrolled form a birth cohort study. FPG and mTG were measured at 24–28 weeks. We analyzed the association of maternal prepregancy overweight/obesity with LGA and mediation effects of FPG and mTG. Multivariable logistic regression analysis and serial multiple mediation analysis were performed. The odds ratio (OR) and 95% confidence intervals (CIs) were calculated. Results Mothers who were overweight or obese had higher odds of giving birth to LGA after adjusting potential confounders (OR:1.88, 95%CI: 1.60–2.21; OR:2.72, 95%CI: 1.93–3.84, respectively). The serial multiple mediation analysis found prepregnancy overweight can not only have a direct positive effect on LGA (effect = 0.043, 95% CI: 0.028–0.058), but also have an indirect effect on the LGA through two paths: the independent mediating role of FPG (effect = 0.004, 95% CI: 0.002–0.005); the independent mediating role of mTG (effect = 0.003,95% CI: 0.002–0.005). The chain mediating role of FPG and mTG has no indirect effect. The estimated proportions mediated by FPG and mTG were 7.8% and 5.9%. Besides, the prepregnancy obesity also has a direct effect on LGA (effect = 0.076; 95%CI: 0.037–0.118) and an indirect effect on LGA through three paths: the independent mediating role of FPG (effect = 0.006; 95%CI: 0.004–0.009); the independent mediating role of mTG (effect = 0.006; 95%CI: 0.003–0.008), and the chain mediating role of FPG and mTG (effect = 0.001; 95%CI: 0.000-0.001). The estimated proportions were 6.7%, 6.7%, and 1.1%, respectively. Conclusion This study found that in nondiabetic women, maternal overweight/obesity was associated with the occurence of LGA, and this positive association was partly mediated by FPG and mTG, suggesting that FPG and mTG in overweight/obese nondiabetic mothers deserve the attention of clinicians.
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- 2023
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23. Effects of GmERF5-Responsive Effector on Soybean Symbiotic Nodulation
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Candong Li, Yuxin Jin, Weinan Tang, Xuemei Li, Chunyan Liu, Jinhui Wang, Xiaoxia Wu, Qingshan Chen, Feishi Luan, and Dawei Xin
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nodule ,soybean–Rhizobium interaction ,NopC ,GmERF5 ,Agriculture - Abstract
The type III secretion system (T3SS) of Rhizobium plays a crucial role during the establishment of the soybean (Glycine max (L.) Merr.)-Rhizobium symbiosis system. Additionally, host-specific nodulation may also depend on the Nops (nodulation outer proteins) secreted by the T3SS of Rhizobium. However, there is limited understanding of the response of soybean genes to Nops. In this study, a NopC mutant, HH103ΩNopC, was constructed from Sinorhizobium fredii HH103 and then utilized to assess the impact of the NopC on nodulation. An RNA-seq analysis revealed that the GmERF5 (Glycine max Ethylene Responsive Factor 5) gene was induced by NopC, which was confirmed by qRT-PCR. Furthermore, an overexpression of the GmERF5 hair-root system was constructed to investigate the effect of GmERF5 on nodulation and its interaction with NopC. Differences in nodule number and nodule dry weight in the overexpression of the GmERF5 hair-root system supported the conclusion that GmERF5 can regulate soybean nodule phenotype via NopC. These results elucidate the genetic mechanisms that regulate nodule phenotype in soybean.
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- 2024
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24. Chemical ordering induced elastic hardening and thermoelastic properties of β phase Mg1-xScx lightweight shape memory alloys
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Narisu Bao, You Zhou, Lin-ping Sun, Xibin Li, Xiaoxia Wu, and B. Narsu
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Mg-Sc alloy ,Chemical ordering ,Thermoelastic properties ,Density functional theory ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The effect of chemical ordering on the thermoelastic properties of Mg-Sc light weight shape memory alloys are studied by the exact muffin-tin orbital method. Chemical ordering has significant hardening effect on elastic properties of Mg-Sc alloys, the C' is increased by 21% for Mg76Sc24 alloy, and the elastic hardening due to ordering can properly explain the increase in Vickers hardness observed in experiment. The quasi-harmonic Debye-Grüneisen model simulated the order–disorder transition temperature reasonably. The vibrational entropy increase due to elastic softening induced by disordering contributes considerably in driving the order–disorder transition. Mg-Sc alloys in ordered phase shows better thermoelastic stability over well-known commercial Mg alloys, therefore, ordering treatment of Mg-Sc are beneficial for structural application of this family of alloys. The Sc atoms (Mg atoms either) in bcc nearest neighboring lattice repel each other to form a B2-type ordered phase, and resultantly, the s-d and p-d hybridization between nearest neighboring Mg and Sc atoms is the main electronic reason for elastic hardening. The findings in current article not only give insight into understanding the strengthening mechanism during the ordering process of Mg-Sc alloys, but also provides a useful reference for the future development and modification of their shape memory effects.
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- 2024
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25. ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression
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Xuanhui Wu, Yong Wang, Bingyi Chen, Yongbo Liu, Fang Li, Yangjing Ou, Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Lingxia Wang, Wuwei Rong, Jianling Liu, Mingyan Xing, Xiaoming Zhao, Han Liu, Lingling Ge, Ankang Lv, Lan Wang, Zhichao Wang, Ming Li, and Haibing Zhang
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ABIN1 ,ABIN1(Q478) ,IFN‐I ,RIPK3 ,MDS‐liked diseases ,Science - Abstract
Abstract A20‐binding inhibitor of NF‐κB activation (ABIN1) is a polyubiquitin‐binding protein that regulates cell death and immune responses. Although Abin1 is located on chromosome 5q in the region commonly deleted in patients with 5q minus syndrome, the most distinct of the myelodysplastic syndromes (MDSs), the precise role of ABIN1 in MDSs remains unknown. In this study, mice with a mutation disrupting the polyubiquitin‐binding site (Abin1Q478H/Q478H) is generated. These mice develop MDS‐like diseases characterized by anemia, thrombocytopenia, and megakaryocyte dysplasia. Extramedullary hematopoiesis and bone marrow failure are also observed in Abin1Q478H/Q478H mice. Although Abin1Q478H/Q478H cells are sensitive to RIPK1 kinase–RIPK3–MLKL‐dependent necroptosis, only anemia and splenomegaly are alleviated by RIPK3 deficiency but not by MLKL deficiency or the RIPK1 kinase‐dead mutation. This indicates that the necroptosis‐independent function of RIPK3 is critical for anemia development in Abin1Q478H/Q478H mice. Notably, Abin1Q478H/Q478H mice exhibit higher levels of type I interferon (IFN‐I) expression in bone marrow cells compared towild‐type mice. Consistently, blocking type I IFN signaling through the co‐deletion of Ifnar1 greatly ameliorated anemia, thrombocytopenia, and splenomegaly in Abin1Q478H/Q478H mice. Together, these results demonstrates that ABIN1(Q478) prevents the development of hematopoietic deficiencies by regulating type I IFN expression.
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- 2024
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26. How green credit affects corporate environmental information disclosure: evidence from new energy listed companies in China
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Limin Geng, Wenxin Yin, Xiaoxia Wu, Xueyuan Lu, and Can Zhang
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environmental information disclosure ,ecological environment ,green credit ,new energy companies ,heterogeneity analysis ,Evolution ,QH359-425 ,Ecology ,QH540-549.5 - Abstract
IntroductionEnvironmental information disclosure is an important means to protect the ecological environment, and global climate change puts forward higher requirements for corporate environmental information disclosure. New energy companies play an important role in addressing climate change and environmental information disclosure, and should strengthen environmental information disclosure and actively participate in ecological environmental protection.MethodsThis paper selected Chinese new energy listed companies as the research sample to investigate the impact of green credit on corporate environmental information disclosure, and proposed and empirically tested the hypothesis on the mechanism of the effect of green credit on environmental information disclosure.ResultsThe regression results indicated that green credit can effectively improve the quality of corporate environmental information disclosure, and this conclusion is still significantly valid after robustness test; The impact mechanism tests showed that green credit can change the level of corporate environmental information disclosure by controlling company size. This paper also tested the heterogeneity and adjustment effects, showing that the relationship between green credit and environmental information disclosure are affected by multiple factors.DiscussionsCombining the research of this paper and previous research results, it is found that the positive impact of green credit on corporate environmental information disclosure has been confirmed by academic research and practical verification. However, the implementation effect of green credit policy will be affected by the economic level, regional differences, and the comprehensive impact from companies, financial institutions and government departments.
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- 2023
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27. PELI1 and EGFR cooperate to promote breast cancer metastasis
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Jie Qi, Guangsen Xu, Xiaoxia Wu, Chunhua Lu, Yuemao Shen, and Baobing Zhao
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis and metastasis. However, the molecular mechanism underlying the high expression and oncogenic roles of PELI1 in cancers remains limited. Herein, we revealed a novel regulation mechanism by which PELI1 and EGFR cooperate to promote breast cancer metastasis. EGFR is positively correlated with PELI1 expression in breast cancers, and its activation led to the phosphorylation of PELI1 at Tyr154 and Thr264, which subsequently activated its E3 ubiquitin ligase. Simultaneously, PELI1 physically interacted with and enhanced the stability of EGFR via the K63-linked polyubiquitination in reverse. The co-inhibition of the PELI1-EGFR showed synergetic effect to repress breast cancer metastasis. Furthermore, we identified a compound S62 as a small molecule disruptor of PELI1/EGFR that effectively repressed breast cancer metastasis. Our study not only uncovered the emerging roles of PELI1/EGFR interaction in the progression of breast cancer, but also provided an effective strategy for the inhibition of metastasis in breast cancer.
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- 2023
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28. miR-150-5p in neutrophil-derived extracellular vesicles associated with sepsis-induced cardiomyopathy in septic patients
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Rongzong Ye, Qiuyun Lin, Wenkai Xiao, Lixia Mao, Pengfei Zhang, Lingshan Zhou, Xiaoxia Wu, Nannan Jiang, Xihe Zhang, Yinhua Zhang, Daqing Ma, Jiahao Huang, Xiaoyan Wang, and Liehua Deng
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Introduction Early diagnosis and potential therapeutic targets of sepsis-induced cardiomyopathy (SIC) remain challenges clinically. Circulating extracellular vesicles from immune cells carrying crucial injurious mediators, including miRNAs in sepsis. However, the impacts of neutrophil-derived extracellular vesicles and their miRNAs in the SIC development are unknown. Objectives The present study focused on the in-depth miRNA expression profiles of neutrophil-derived extracellular vesicles and explored the potential molecular biomarkers during the process of SIC. Methods Neutrophil-derived extracellular vesicles were isolated from the blood samples in three sepsis patients with or without cardiomyopathy on day 1 and day 3 after ICU admission in comparison with three healthy controls. miRNAs were determined by RNA sequencing. The closely related differentially expressed miRNAs with SIC were further validated through qRT-PCR in the other cohorts of sepsis patients with (30 patients) or without cardiomyopathy (20 patients) and the association between miRNAs and the occurrence or disease severity of septic cardiomyopathy were stratified with logistic regression analysis. Results Sixty-eight miRNAs from neutrophil-derived extracellular vesicles were changed significantly between healthy controls and without septic cardiomyopathy patients (61 miRNAs upregulated and seven downregulated). Thirty-eight miRNAs were differentially expressed in the septic cardiomyopathy patients. 27 common differentially expressed miRNAs were found in both groups with similar kinetics (23 miRNAs upregulated and four downregulated). The enriched cellular signaling pathway mediated by miRNAs from sepsis to septic cardiomyopathy was the HIF-1 signaling system modulated septic inflammation. Using multivariate logistic regression analysis, miR-150-5p coupled with NT-pro BNP, LVEF, and SOFA score (AUC = 0.941) were found to be the independent predictors of septic cardiomyopathy. Conclusion miRNAs derived from neutrophil-derived extracellular vesicles play an important role in septic disease severity development towards cardiomyopathy. miR-150-5p may be a predictor of sepsis severity development but warrants further study.
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- 2023
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29. Curvature Sensing-Based Pupil Alignment Method for Large-Aperture Telescopes
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Qichang An, Hanfu Zhang, Xiaoxia Wu, Jianli Wang, Tao Chen, and Guohao Ju
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Aperture coding ,curvature sensing ,large-aperture telescope ,pupil misalignment ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
In optical systems, pupil alignment is an important component of wavefront sensing, closed-loop feedback, and imaging vignetting control because it directly affects the detection limit of the system and thus the realization of scientific goals. This study proposes the use of the energy transfer characteristics of the pupil edge to determine the misalignment of each pupil. The mechanism involves decoupling the influence of each pupil from the final exit pupil energy distribution by using aperture coding without the addition of other optical paths. The degree to which the pupil is aligned is characterized by the normalized point source sensitivity (PSSn). The pupil misalignment PSSn increased from 0.75 to 0.83. The results of this study can be used to perform tomographic detection of pupil alignment and obtain high-quality telescopic images.
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- 2023
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30. In-Situ Metrology of Large Segmented Detector Based on Modified Optical Truss
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Qichang An, Hanfu Zhang, Xiaoxia Wu, Jianli Wang, Tao Chen, Jingxu Zhang, and Hongwen Li
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Large survey telescope ,active optics ,optical truss ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
To precisely map cosmic structures and capture time-domain events, future large survey telescopes will be equipped with segmented detectors that greatly expand their field of view. Segment flatness and assembly accuracy will be essential for them to make accurate observations. Instead of physically measuring distances between adjacent mirror surfaces, our modified optical truss enables the angle (slope) between them to be calculated. Furthermore, we calculated the relative tilt and piston between the segmented detectors. The modified optical truss can measure the flatness of a mosaicked detector before and after it is assembled into a telescope. We reduced the volume, weight, and power of our device compared with earlier versions. Its angular accuracy is now better than 0.1 arcsecs, and, at a maximum scope of 500 µm, the linear accuracy of the new truss is better than 25 µm. In fact, accuracy and testing ranges are comparable to instruments found in optics labs.
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- 2023
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31. Protocol for preparing dynamic covalent macrocycles for co-delivering genes and drugs to cancer cell lines
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Yonglei Lyu, Xiaoxia Wu, Jinghui Yang, Xin Wang, and Jianwei Li
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Chemistry ,Material sciences ,Science (General) ,Q1-390 - Abstract
Summary: Combination therapy using effective drug molecules and functional genes such as small interfering RNA (siRNA) has been suggested as a powerful strategy against multiple drug resistance. Here, we present a protocol for preparing a delivery system by developing dynamic covalent macrocycles using a dithiol monomer to co-deliver doxorubicin and siRNA. We describe steps for preparing the dithiol monomer, followed by co-delivery to form nanoparticles. We then detail procedures for cell uptake and assessing enhanced anti-cancer efficacy in vitro.For complete details on the use and execution of this protocol, please refer to Lyu et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
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- 2023
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32. AdaLoss: A Computationally-Efficient and Provably Convergent Adaptive Gradient Method.
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Xiaoxia Wu, Yuege Xie, Simon Shaolei Du, and Rachel A. Ward
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- 2022
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33. Removable Edges in Claw-Free Bricks.
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Xiaoxia Wu, Fuliang Lu, and Lianzhu Zhang
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- 2024
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34. Chemical-structural coupling in Magnesium-Scandium alloys
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You Zhou, Linping Sun, Meiling Ding, Narisu Bao, Xiaoxia Wu, and B. Narsu
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MgSc alloy ,Martensitic phase ,Chemical ordering ,Mechanical property ,Physics ,QC1-999 - Abstract
The chemical ordering and its effect on structure and elastic properties of Mg1-xScx alloys are studied by ab initio method. The MgSc alloys show strong chemical long range ordering tendency as the Sc concentration increase. The predicted martensitic phase of fully disordered alloy is hcp when the transformation occurs through the Burgers path. Chemical long range ordering could lead to a lattice distortion and results in a low symmetric orthorhombic martensitic phase, namely, there is a chemical-structural coupling in MgSc alloys. The chemical long range ordering also has strong hardening effect, the single crystalline elastic moduli C′, C44, Young’s modulus and Shear modulus are increased by 12.6%, 4.2%, 4.4% and 5% for Mg80Sc20 alloy, respectively. Electronic structure analysis showed that the additional s-d and p-d hybridization between near neighboring Mg and Sc ions in ordered phase is accounting for the elastic hardening and chemical-structural coupling in MgSc alloys.
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- 2023
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35. Scientific connotation of the compatibility of traditional Chinese medicine from the perspective of the intestinal flora
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Yuan Gao, Xiaoxia Wu, Ning Zhao, and Dong Bai
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Chinese medicine ,traditional Chinese medicine ,compatibility ,synergy and attenuation ,contraindicated combination ,intestinal flora ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Revealing the connotation of the compatibility of Chinese medicines (CM) is a requirement for the modernization of traditional Chinese medicine (TCM). However, no consensus exists on the specific mechanism of traditional Chinese medicine compatibility (TCMC). Many studies have shown that the occurrence and development of diseases and the efficacy of CM are closely related to intestinal flora (IF), which may provide a new perspective to understand the theory of TCM. This study aimed to summarize the relationship between the changes in IF before and after the compatibility of different drugs and the synergistic, toxicity reduction, and incompatibility effects of drug pairs from the perspective of the effects of CM on the IF and the regulation of microbial metabolites. These studies showed that the effect of drug pairs on the composition of the IF is not a simple superposition of two single drugs, and that the drug pairs also play a specific role in regulating the production of intestinal bacterial metabolites; therefore, it has a different pharmacodynamic effect, which may provide a perspective to clarify the compatibility mechanism. However, research on the interpretation of the scientific connotations of TCMC from the perspective of the IF is still in its infancy and has limitations. Therefore, this study aimed to summarize previous research experience and proposed to conduct a deep and systematic study from the perspective of drug pair dismantling, IF, intestinal bacteria metabolite, organism, and disease to provide a reference for scientific research on the compatibility mechanism of CM.
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- 2023
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36. GmTNRP1, associated with rhizobial type‐III effector NopT, regulates nitrogenase activity in the nodules of soybean (Glycine max)
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Chao Ma, Chunyan Liu, Yanyu Yu, Shengnan Ma, Siyang Pan, Haojie Feng, Qingshan Chen, Dawei Xin, Xiaoxia Wu, and Jinhui Wang
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functional study ,nitrogenase activity ,QTL ,soybean ,symbiosis ,type‐III effector ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Abstract Soybean is a rich source of protein and oil for humans. It forms a symbiotic association with rhizobia to fix atmospheric nitrogen for its growth and development. Rhizobial type‐III effectors act as important signaling molecules in symbiosis. However, they are poorly studied. In this study, mutation of TtsI in Sinorhizobium fredii HH103 reduced nodule numbers and dry weights in SN14 (cultivated soybean) and ZYD00006 (wild soybean). Moreover, it reduced nitrogenase activity in SN14 but not in ZYD00006. Based on the differences in nitrogenase activity between SN14 and ZYD00006 inoculated with HH103 and the TtsI mutant, two conditional quantitative trait loci associated with nitrogenase activity were identified in chromosome segment substitution lines derived from SN14 and ZYD00006. Using transcriptome analysis, single‐nucleotide polymorphism (SNP) analysis, and qRT‐PCR, Glyma.13G150000 (GmTNRP1) was identified as a candidate gene in soybean that was associated with nitrogenase activity, along with NopT (a type‐III effector). In addition, GmTNRP1 (an LRR‐RK family protein located on the cell membrane) was observed to be induced by NopT to negatively regulate nitrogenase activity. In transgenic hairy roots with GmTNRP1 silencing, no significant difference was observed in terms of nitrogenase activity between nodules inoculated with the NopT mutant and those inoculated with HH103 (wild type). However, the nitrogenase activity in the nodules decreased after overexpression of GmTNRP1. SNP located in the GmTNRP1 promoter affected its expression in response to NopT. Haplotype analysis revealed that SN14 belonged to Hap1 and ZYD00006 belonged to Hap2, which explained the different results in the two varieties. To the best of our knowledge, this is the first study to identify a soybean gene associated with a rhizobial type‐III effector in the nodules. GmTNRP1 can negatively regulate nitrogenase activity in the nodules. This study enhanced the understanding of the mechanism underlying symbiotic association between soybean and rhizobia.
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- 2023
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37. Observation of plasma dynamics in a theta pinch by a novel method
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Zhao Wang, Rui Cheng, Guodong Wang, Xuejian Jin, Yong Tang, Yanhong Chen, Zexian Zhou, Lulin Shi, Yuyu Wang, Yu Lei, Xiaoxia Wu, and Jie Yang
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
A novel experimental method is proposed for observing plasma dynamics subjected to magnetic fields based on a newly developed cylindrical theta-pinch device. By measuring simultaneously the temporal profiles of multiple parameters including the drive current, luminosity, plasma density, and plasma temperature, it provides a basis for observing the plasma dynamics of the theta pinch, such as shock transport and magnetohydrodynamic instability. We show that the plasma evolution can be distinguished as three phases. First, in the radial implosion phase, the trajectories of the current sheath and shock wave are ascertained by combining experimental data with a snowplow model (Lee model) in a self-consistent way. Second, in the axial flow phase, we demonstrate that m = 0 (sausage) instability associated with the plasma axial flow suppresses the plasma end-loss. Third, in the newly observed anomalous heating phase, the lower-hybrid-drift instability may develop near the current sheath, which induces anomalous resistivity and enhanced plasma heating. The present experimental data and novel method offer better understanding of plasma dynamics in the presence of magnetic fields, thereby providing important support for relevant research in magneto-inertial fusion.
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- 2023
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38. Gold nanorods with iron oxide dual-modal bioprobes in SERS-MRI enable accurate programmed cell death ligand-1 expression detection in triple-negative breast cancer
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Ting Pan, Dinghu Zhang, Xiaoxia Wu, Zihou Li, Hui Zeng, Xiawei Xu, Chenguang Zhang, Yiwei He, Yuanchuan Gong, Pin Wang, Quanliang Mao, Junlie Yao, Jie Lin, Aiguo Wu, and Guoliang Shao
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Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
The efficiency of immunotherapy for triple-negative breast cancer (TNBC) is relatively low due to the difficulty in accurately detecting immune checkpoints. The detection of TNBC-related programmed cell death ligand-1 (PD-L1) expression is important to guide immunotherapy and improve treatment efficiency. Surface-enhanced Raman spectroscopy (SERS) and magnetic resonance (MR) imaging exhibit great potential for early TNBC diagnosis. SERS, an optical imaging mode, has the advantages of high detection sensitivity, good spatial resolution, and “fingerprint” spectral characteristics; however, the shallow detection penetration of SERS bioprobes limits its application in vivo. MR has the advantages of allowing deep penetration with no radiation; however, its spatial resolution needs to be improved. SERS and MR have complementary imaging features for tumor marker detection. In this study, gold nanorod and ultrasmall iron oxide nanoparticle composites were developed as dual-modal bioprobes for SERS-MRI to detect PD-L1 expression. Anti-PD-L1 (aPD-L1) was utilized to improve the targeting ability and specificity of PD-L1 expression detection. TNBC cells expressing PD-L1 were accurately detected via the SERS imaging mode in vitro, which can image at the single-cell level. In addition, bioprobe accumulation in PD-L1 expression-related tumor-bearing mice was simply and dynamically monitored and analyzed in vivo using MR and SERS. To the best of our knowledge, this is the first time a SERS-MRI dual-modal bioprobe combined with a PD-L1 antibody has been successfully used to detect PD-L1 expression in TNBC. This work paves the way for the design of high-performance bioprobe-based contrast agents for the clinical immunotherapy of TNBC.
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- 2023
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39. Which fetal growth charts should be used? A retrospective observational study in China
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Jianxin Zhao, Ying Yuan, Jing Tao, Chunyi Chen, Xiaoxia Wu, Yimei Liao, Linlin Wu, Qing Zeng, Yin Chen, Ke Wang, Xiaohong Li, Zheng Liu, Jiayuan Zhou, Yangwen Zhou, Shengli Li, Jun Zhu, and Jing Ni
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Medicine - Abstract
Abstract. Background:. The fetal growth charts in widest use in China were published by Hadlock >35 years ago and were established on data from several hundred of American pregnant women. After that, >100 fetal growth charts were published around the world. We attempted to assess the impact of applying the long-standing Hadlock charts and other charts in a Chinese population and to compare their ability to predict newborn small for gestational age (SGA). Methods:. For this retrospective observational study, we reviewed all pregnant women (n = 106,455) who booked prenatal care with ultrasound measurements for fetal biometry at the Shenzhen Maternity and Child Healthcare Hospital between 2012 and 2019. A fractional polynomial regression model was applied to generate Shenzhen fetal growth chart ranges for head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL). The differences between Shenzhen charts and published charts were quantified by calculating the Z-score. The impact of applying these published charts was quantified by calculating the proportions of fetuses with biometric measurements below the 3rd centile of these charts. The sensitivity and area under the receiver operating characteristic curves of published charts to predict neonatal SGA (birthweight
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- 2022
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40. Identification of partial trisomy 13q in two unrelated patients using single-nucleotide polymorphism array and literature overview
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Jianlong Zhuang, Chunnuan Chen, Hegan Zhang, Wanyu Fu, Yanqing Li, Yuying Jiang, Shuhong Zeng, Xiaoxia Wu, Yingjun Xie, and Gaoxiong Wang
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Partial trisomy 13q ,Karyotype analysis ,SNP array ,Seizures ,Developmental delay ,Genetics ,QH426-470 - Abstract
Abstract Background Partial trisomy 13q is a less common chromosomal abnormality with a great clinical variability, among them, isolated partial trisomy 13q is extremely rare. Here, we report two new unrelated cases of partial trisomy 13q in Chinese families aiming to emphasize the genotype–phenotype correlation in partial trisomy 13q. Methods Enrolled in this study were two unrelated cases of partial 13q trisomy from two families in Quanzhou region South China. Karyotpe and single-nucleotide polymorphism (SNP) array analysis were employed to identify chromosome abnormalities and copy number variants in the families. Results A 72.9-Mb duplication in 13q14.11q34 region was identified using SNP array analysis in Patient 1 with an intellectual disability, developmental delay, seizures, gastric perforation, and other congenital malformations from a family with paternal inv(13)(p12q14.1). SNP array detection in Patient 2 revealed a 92.4-Mb duplication in 13q12.11q34 region combined with an 8.4-Mb deletion in Xq27.3q28 region with intellectual disability, developmental delay, cleft palate, and duplication of the cervix and the vagina. No chromosomal abnormality was elicited from the parents of Patient 2. Conclusions In this study, we presented two new unrelated cases of partial trisomy 13q with variable features in Chinese population, which may enrich the spectrum of the phenotypes partial trisomy 13q and further confirm the genotype–phenotype correlation.
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- 2022
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41. The healing response of LAMax LAAC™ left atrial appendage occluder in a canine model: the potential influence of the implantation technique on the healing response
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Xiaoxia Wu, Dongxing Ma, Tao Wan, Yuezhi Meng, Yilong Chen, Yejia Shen, and Wei Huang
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Left atrial appendage occluder ,Healing response ,Implantation principle ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Device-associated thrombus are potential causes for thromboembolic events post left atrial appendage closure (LAAC), and correlated with the complete endothelialization of the device surface. Our aim was to evaluate the endothelialization of LAMax LAAC™ occluder surface and analyze the potential influence of the implantation technique on the healing response. Methods A total of 29 healthy dogs (28.0 ± 3.7 kg) were implanted with the devices successfully after ensuring COVER signs was met (Concavity of the disc, Oversizing by 20–50%, Verifying position, Ensuring stability, Residual flow
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- 2022
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42. Genome-Wide Association Analysis of Cowpea Mild Mottle Virus Resistance in Soybean Germplasms from Northeast China
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Yameng Luan, Siqi Yang, Yuting Wang, Yu Zhao, Xiaoyun Wu, Qingshan Chen, Zhaoming Qi, Xiaoxia Wu, Weiqin Ji, and Xiaofei Cheng
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soybean ,CpMMV ,GWAS ,SNP ,resistance genes ,Agriculture - Abstract
Cowpea mild mottle virus (CpMMV) is an important viral pathogen that seriously influences the yield and seed quality of soybeans worldwide. Resistance breeding is one of the most effective, economical, and environmentally safe strategies for controlling the disease caused by CpMMV. However, only few resistance genes have been identified in soybeans. In this study, the resistance of 169 soybean germplasms from Northeast China to a CpMMV strain isolated from soybean in China was evaluated, and a genome-wide association study (GWAS) was then performed to find possible resistance genes in these soybean germplasms. Nine resistant soybean germplasms were identified and two single nucleotide polymorphism sites (SNPs) were found to be closely associated with CpMMV resistance. A total number of 51 and 25 candidate genes neighboring the resistance-associated SNPs on chromosomes 6 and 12, respectively, were identified, among which one receptor-like kinase (RLK) on chromosome 6 and 2 toll-interleukin-1 receptor nucleotide-binding leucine-rich repeat receptors (TNLs) on chromosome 12 were recognized as the most probable resistance genes, respectively. Together, these data provide new insights on the resistance resources of soybeans to CpMMV, which will benefit the breeding of CpMMV-resistant soybean cultivars.
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- 2024
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43. Excessive gestational weight gain in early pregnancy and insufficient gestational weight gain in middle pregnancy increased risk of gestational diabetes mellitus
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Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu, Ningning Wang, and Peifang Wei
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Medicine - Abstract
Abstract. Background:. Gestational weight gain (GWG) is associated with the risk of gestational diabetes mellitus (GDM). However, the effect of weight gain in different trimesters on the risk of GDM is unclear. This study aimed to evaluate the effect of GWG on GDM during different trimesters. Methods:. A birth cohort study was conducted from 2017 to 2020 in Shenzhen, China. In total, 51,205 participants were included comprising two models (early pregnancy model and middle pregnancy model). Gestational weight (kg) was measured at each prenatal clinical visit using a standardized weight scale. Logistic regression analysis was used to assess the risk of GDM. Interaction analysis and mediation effect analysis were performed in the middle pregnancy model. Results:. In the early pregnancy model, the risk of GDM was 0.858 times lower (95% confidence interval [CI]: 0.786, 0.937) with insufficient GWG (iGWG) and 1.201 times higher (95% CI: 1.097, 1.316) with excessive GWG after adjustment. In the middle pregnancy model, the risk of GDM associated with iGWG increased 1.595 times (95% CI: 1.418, 1.794) after adjustment; for excessive GWG, no significant difference was found (P = 0.223). Interaction analysis showed no interaction between GWG in early pregnancy (GWG-E) and GWG in middle pregnancy (GWG-M) (F = 1.268; P = 0.280). The mediation effect analysis indicated that GWG-M plays a partial mediating role, with an effect proportion of 14.9%. Conclusions:. eGWG-E and iGWG-M are associated with an increased risk of GDM. Strict control of weight gain in early pregnancy is needed, and sufficient nutrition should be provided in middle pregnancy.
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- 2022
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44. A soybean NAC homolog contributes to resistance to Phytophthora sojae mediated by dirigent proteins
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Guolong Yu, Jianan Zou, Jinhui Wang, Rongsheng Zhu, Zhaoming Qi, Hongwei Jiang, Zhenbang Hu, Mingliang Yang, Ying Zhao, Xiaoxia Wu, Chunyan Liu, Candong Li, Xue Yang, Zhendong Zhu, Qingshan Chen, Yongfu Fu, and Dawei Xin
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Phytophthora sojae ,Soybean ,GmNAC1 ,Dirigent ,Lignin ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Phytophthora sojae infection severely impairs soybean production. We previously identified a dirigent protein, GmDRR1 (Glycine max Disease Resistant Response 1), that increases soybean resistance to P. sojae. However, the molecular basis of GmDRR1 function remained largely uncharacterized. In the present study, analysis of GmDRR1-RNAi, GmDRR1-overexpressing, and CRISPR/Cas9-derived Gmdrr1 mutant lines revealed that GmDRR1 expression significantly restricted P. sojae growth. Combining co-immunoprecipitation with liquid chromatography–tandem mass spectrometry revealed a GmDRR1-interacting protein, GmDRR2, which is homologous to GmDRR1. An E-coniferyl alcohol coupling assay indicated that GmDRR1 promotes the synthesis of (+)-pinoresinol, which helps to protect plants from P. sojae. The GmNAC1 (Glyma.05G025500) transcription factor bound to the GmDRR1 promoter both in vitro and in vivo to upregulate GmDRR1 expression. Soybean resistance to P. sojae was increased by overexpression of GmNAC1. Our findings suggest a novel signaling pathway involving a NAC transcription factor that mediates soybean resistance to P. sojae. Specifically, GmNAC1 directly induces GmDRR1 expression to increase resistance of soybean plants to P. sojae.
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- 2022
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45. Effect of megarectum on postoperative defecation of female patients with congenital rectovestibular fistula or rectoperineal fistula
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Chunxiang Liu, Song Wang, Jinyu Dai, Jian Li, Xiaoxia Wu, Yong Liu, Zhiwei Yao, Lushun Ma, Xiaobing Sun, and Daqing Sun
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anorectal malformation ,rectovestibular fistula ,rectoperineal fistula ,megarectum ,defecation ,Pediatrics ,RJ1-570 - Abstract
BackgroundTo assess the effect of megarectum on postoperative defecation of female patients with congenital rectovestibular fistula or rectoperineal fistula.MethodsFrom March 2013 to February 2021, 74 female patients with congenital rectovestibular fistula or rectoperineal fistula were treated. The age of patients ranged from 3 months to 1 year. Barium enema and spinal cord MRI were performed in all children. 4 patients were removed from the study because of spinal cord and sacral agenesis. Finally, 70 patients underwent one-stage anterior sagittal anorectoplasty (ASARP). Anal endoscopy and anorectal pressure measurement were performed 1 year after surgery. All patients were divided into two groups depending on the presence of megarectum (+) and (−) and observed for constipation and anal sphincter function.Results16 patients (4 months to 1 year) were complicated with megarectum, and 5 patients (3 months to 9 months) were without megarectum. The incision infection was seen in 3 patients. All patients were followed up for 1 year to 5 years. Fecal soiling was seen in 2 patients and constipation in 14 patients. Among 16 patients with megarectum, soiling was seen in 1 patient and the constipation in 12 patients. Among 54 patients without megarectum, soiling was seen in 1 patient and constipation in 2 patients. There was a significant difference in the incidence of postoperative constipation between the two groups (megarectum (+) 75% vs. megarectum (−) 3.7% (P
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- 2023
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46. Functional insights of plant bcl-2–associated ahanogene (BAG) proteins: Multi-taskers in diverse cellular signal transduction pathways
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Hailong Jiang, Xiaoya Liu, Peixiang Xiao, Yan Wang, Qihui Xie, Xiaoxia Wu, and Haidong Ding
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abiotic and biotic stress ,Bcl-2-associated athanogene (BAG) ,functional mechanism ,plant development ,protein structure ,Plant culture ,SB1-1110 - Abstract
Bcl-2-associated athanogene (BAG) gene family is a highly conserved molecular chaperone cofactor in evolution from yeast to humans and plants playing important roles in a variety of signal pathways. Plant BAG proteins have special structures, especially those containing CaM-binding IQ motifs which are unique to plants. While early studies focused more on the structure and physiological function of plant BAGs, recent studies have revealed many novel functional mechanisms involved in multiple cellular processes. How to achieve signal specificity has become an interesting topic of plant BAG research. In this review, we have provided a historic view of plant BAG research and summarized recent advances in the establishment of BAG as essential components in normal plant growth, environmental stress response, and plant immunity. Based on the relationship between BAG proteins and their newly interacting proteins, this review highlights the functional mechanisms of various cellular signals mediated by plant BAGs. Future work needs to focus on the post-translational modification of BAG proteins, and on understanding how specificity is achieved among BAG signaling pathways.
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- 2023
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47. GmBBM7 promotes callus and root growth during somatic embryogenesis of soybean (Glycine max)
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Runnan Zhou, Yujing Zhao, Peng Cheng, Binshuo Zhang, Zhen Liu, Sihui Wang, Haibo Li, Qingshan Chen, Ying Zhao, Sinan Li, and Xiaoxia Wu
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Glycine max ,GmBBM7 ,bioinformatics analysis ,callus ,hairy root ,molecular characteristics ,Biotechnology ,TP248.13-248.65 - Abstract
The BABY BOOM (BBM) subfamily of the AP2/ERF transcription factor family is the main regulator of totipotency in plant cells and plays an important role in regulating cell proliferation and plant growth and development. Previously, we identified GmBBM7, a key gene of the soybean BBM gene subfamily (GmBBM family). In this study, we aimed to analyze its molecular characteristics and role in somatic embryogenesis in soybean. First, we identified 17 members of GmBBM family. Phylogenetic and collinear analyses revealed that the GmBBM family genes mainly exhibited a strong genetic relationship with the those of PvBBM family, the BBM family of common bean (Phaseolus vulgaris). Analysis of the promoters revealed that GmBBM family genes were mainly regulated by plant hormones. The expression of GmBBM7 varied in various tissues of soybean. Particularly, it was higher in the roots, immature embryos, grains and callus. Subcellular localization analysis indicated that GmBBM7 encodes a nuclear protein. Furthermore, overexpressed GmBBM7 could significantly enhance callus formation by regulating the levels of gibberellin A1, A3 and A7; abscisic acid; and salicylic acid and could promote root growth and development. In summary, GmBBM7 is an important regulatory gene for somatic embryogenesis and root elongation in soybean. GmBBM7 overexpression in soybean could increase the callus formation rate and density through hormonal pathways and could increase root growth. This study provided theoretical basis for efficient breeding of soybean via gene editing, transgenic and other techniques.
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- 2023
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48. Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study
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Yixuan Chen, Linlin Wu, Hangkuan Liu, Ziping Li, Linjie Li, Xiaoxia Wu, Qiong Lei, Aiqi Yin, Jianing Tong, Kan Liu, Xiaonian Guan, Cuiping Zeng, Huafan Zhang, Yanmei Wan, Xuna Huang, Pingping Huang, Qing Yang, Xin Zhou, and Jianmin Niu
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biomarker ,chemerin ,hypertension ,prediction model ,preeclampsia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Limited data are available for postpartum hypertension prediction after preeclampsia. Methods and Results We examined the association between maternal serum chemerin levels in patients with preeclampsia and blood pressure (BP) levels after delivery in a prospective birth cohort of 15 041 singleton pregnant women. A total of 310 cases among 322 patients with preeclampsia (follow‐up rate, 96.3%) were followed up during a mean 2.8 years after delivery. Compared with matched uncomplicated controls (n=310), serum chemerin measured at ≈35 gestational weeks was significantly increased in preeclampsia (171.8±49.2 versus 140.2±53.5 ng/mL; P
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- 2023
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49. DeepSpeed-Chat: Easy, Fast and Affordable RLHF Training of ChatGPT-like Models at All Scales.
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Zhewei Yao, Reza Yazdani Aminabadi, Olatunji Ruwase, Samyam Rajbhandari, Xiaoxia Wu, Ammar Ahmad Awan, Jeff Rasley, Minjia Zhang, Conglong Li, Connor Holmes, Zhongzhu Zhou, Michael Wyatt, Molly Smith, Lev Kurilenko, Heyang Qin, Masahiro Tanaka, Shuai Che, Shuaiwen Leon Song, and Yuxiong He
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- 2023
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50. RenAIssance: A Survey into AI Text-to-Image Generation in the Era of Large Model.
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Fengxiang Bie, Yibo Yang, Zhongzhu Zhou, Adam Ghanem, Minjia Zhang, Zhewei Yao, Xiaoxia Wu, Connor Holmes, Pareesa Ameneh Golnari, David A. Clifton, Yuxiong He, Dacheng Tao, and Shuaiwen Leon Song
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- 2023
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