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27 results on '"Siriki, R."'

1. Long-term creep behaviours and structural stabilities of austenitic heat-resistant stainless steels

Author

Ohlin, O., Siriki, R., Chai, Guocai, Ohlin, O., Siriki, R., and Chai, Guocai

Abstract

For heat resistant alloys, long-term structural stability at high temperatures is a critical issue for alloy design and applications. In this paper, the long-term creep behaviours and structural stabilities of six heat resistant high Ni alloys and austenitic stainless steels have been studied. The longest creep rupture life is up to 359 283 hours. High Ni and Cr alloys show a good combination of high creep and oxidation resistances. Precipitation of nano MX particles with a very low growth rate improves long-term creep resistance at high temperatures. Long-term stable multiple nanoprecipitates of MX, Cu-rich, Laves and M23C6 phases can greatly contribute to the creep strength. Low Ni austenitic stainless steels show comparatively low oxidation and creep resistances. It was first found that at 800 & DEG;C, Cr2N could form in the low Ni steel with a long-term crept by the absorption of nitrogen from the air into the matrix.

Published
2024
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25. The association of angiogenic factors and chronic kidney disease.

Author

Anderson CE, Hamm LL, Batuman G, Kumbala DR, Chen CS, Kallu SG, Siriki R, Gadde S, Kleinpeter MA, Krane NK, Simon EE, He J, and Chen J

Subjects
Adult, Aged, Angiogenic Proteins blood, Biomarkers blood, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Angiopoietin-1 blood, C-Reactive Protein metabolism, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic diagnosis, Serum Amyloid P-Component metabolism, Vascular Endothelial Growth Factor A blood
Abstract

Background: There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angiopoietin-1, angiopoietin-1/VEGF-A ratio, VEGF receptor 1 (VEGFR-1), VEGFR-2, and pentraxin-3 with CKD., Methods: We recruited 201 patients with CKD and 201 community controls without CKD from the greater New Orleans area. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 or presence of albuminuria. Multivariable quantile and logistic regression models were used to examine the relationship between angiogenesis-related factors and CKD adjusting for confounding factors., Results: After adjusting for covariables including traditional cardiovascular disease (CVD) risk factors, C-reactive protein, and history of CVD, the medians (interquartile range) were 133.08 (90.39, 204.15) in patients with CKD vs. 114.17 (72.45, 170.32) pg/mL in controls without CKD (p = 0.002 for group difference) for VEGF-A; 3951.2 (2471.9, 6656.6) vs. 4270.5 (2763.7, 6537.2) pg/mL (p = 0.70) for angiopoietin-1; 25.87 (18.09, 47.90) vs. 36.55 (25.71, 61.10) (p = 0.0001) for angiopoietin-1/VEGF-A ratio; 147.81 (122.94, 168.79) vs. 144.16 (123.74, 168.05) ng/mL (p = 0.25) for VEGFR-1; 26.20 (22.67, 29.92) vs. 26.28 (23.10, 29.69) ng/mL (p = 0.31) for VEGFR-2; and 1.01 (0.79, 1.49)vs. 0.89 (0.58, 1.18) ng/mL (p = 0.01) for pentraxin-3, respectively. In addition, an elevated VEGF-A level and decreased angiopoietin-1/VEGF-A ratio were associated with increased odds of CKD., Conclusions: These data indicate that plasma VEGF-A and pentraxin-3 levels were increased and the angiopoietin-1/VEGF-A ratio was decreased in patients with CKD. Future prospective studies are warranted to examine whether angiogenic factors play a role in progression of CKD.

Published
2018
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26. Fatal Hypermagnesemia Due to Laxative Use.

Author

Bokhari SR, Siriki R, Teran FJ, and Batuman V

Subjects
Acute Kidney Injury blood, Acute Kidney Injury therapy, Citric Acid therapeutic use, Constipation drug therapy, Fatal Outcome, Female, Humans, Laxatives therapeutic use, Magnesium Oxide therapeutic use, Middle Aged, Organometallic Compounds therapeutic use, Renal Dialysis, Acute Kidney Injury chemically induced, Citric Acid adverse effects, Laxatives adverse effects, Magnesium blood, Magnesium Oxide adverse effects, Organometallic Compounds adverse effects
Abstract

We report a case of fatal hypermagnesemia in a 53-year-old woman admitted for acute exacerbation of chronic obstructive pulmonary disease and with a history of chronic constipation treated regularly with magnesium-containing laxatives. On admission, her magnesium level was 2.0mg/dL, which rose to a peak of 10.8mg/dL despite hydration and diuresis in the presence of a normal kidney function. Continuous renal replacement therapy was promptly initiated, which reduced her serum magnesium levels, but her condition continued to deteriorate precipitously progressing to shock leading to oligoanuric renal failure, and she died 2 days later. A review of the literature shows that though rare and often unsuspected, severe hypermagnesemia frequently results in death even in individuals with normal renal function despite renal replacement therapy. In patients with constipation, retention of magnesium-based laxative in the gut apparently serves as a reservoir for continuous magnesium absorption and contributes to mortality., (Published by Elsevier Inc.)

Published
2018
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