1,514 results on '"Fu, B. A."'
Search Results
2. Genetic determinants of micronucleus formation in vivo
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Adams, D. J., Barlas, B., McIntyre, R. E., Salguero, I., van der Weyden, L., Barros, A., Vicente, J. R., Karimpour, N., Haider, A., Ranzani, M., Turner, G., Thompson, N. A., Harle, V., Olvera-León, R., Robles-Espinoza, C. D., Speak, A. O., Geisler, N., Weninger, W. J., Geyer, S. H., Hewinson, J., Karp, N. A., Fu, B., Yang, F., Kozik, Z., Choudhary, J., Yu, L., van Ruiten, M. S., Rowland, B. D., Lelliott, C. J., del Castillo Velasco-Herrera, M., Verstraten, R., Bruckner, L., Henssen, A. G., Rooimans, M. A., de Lange, J., Mohun, T. J., Arends, M. J., Kentistou, K. A., Coelho, P. A., Zhao, Y., Zecchini, H., Perry, J. R. B., Jackson, S. P., and Balmus, G.
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- 2024
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3. Experimental and numerical investigation on layered UHPC beams incorporated with recycled macro fibers
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Zou, Q.Q., Yang, J.H., Xu, G.T., You, X.M., FU, B., and Kuang, Y.D.
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- 2024
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4. Pullout behavior of recycled macro fibers embedded in ultra-high performance seawater sea-sand concrete
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Deng, D.Y., Lin, L.B., Zhou, Y.W., You, X.M., Fu, B., and Cai, J.G.
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- 2024
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5. Hypertension and its association to phenotype on left ventricular function in hypertrophic cardiomyopathy patients assessed by cardiovascular magnetic resonance imaging
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Yang, Z., Zhang, T.-y., Gui, F.-d., Yao, F.-y., Long, Y.-t., Wen, M., Wang, Z., Meng, X., Fu, B., and Pan, S.-y.
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- 2024
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6. Prognostic Value of Four Preimplantation Malnutrition Estimation Tools in Predicting Heart Failure Hospitalization of the Older Diabetic Patients with Right Ventricular Pacing
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Fu, B., Yu, Y., Cheng, S., Huang, H., Long, T., Yang, J., Gu, M., Cai, C., Chen, X., Niu, H., and Hua, Wei
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- 2023
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7. Remineralization of Dentin with Cerium Oxide and Its Potential Use for Root Canal Disinfection
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Wang Y, Zhang X, Zheng H, Zhou Z, Li S, Jiang J, Li M, and Fu B
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cerium oxide ,dextran ,biomimetic mineralization ,root canal disinfection ,Medicine (General) ,R5-920 - Abstract
Yinlin Wang,1 Xinyue Zhang,2 Haiyan Zheng,1 Zihuai Zhou,1 Si Li,1 Jimin Jiang,1 Mingxing Li,1 Baiping Fu1 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, People’s Republic of China; 2School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Baiping Fu; Mingxing Li, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, People’s Republic of China, Email fbp@zju.edu.cn; 7315019@zju.edu.cnObjective: This study was to investigate a novel antibacterial biomimetic mineralization strategy for exploring its potential application for root canal disinfection when stabilized cerium oxide was used.Material and Methods: A biomimetic mineralization solution (BMS) consisting of cerium nitrate and dextran was prepared. Single-layer collagen fibrils, collagen membranes, demineralized dentin, and root canal system were treated with the BMS for mineralization. The mineralized samples underwent comprehensive characterization using various techniques, including transmission electron microscopy (TEM), high-resolution TEM (HRTEM), Fourier transform infrared spectroscopy (FTIR), scanning transmission electron microscopy (STEM), selected-area electron diffraction (SAED), energy-dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and micro-CT. Additionally, the antimicrobial properties of the BMS and the remineralized dentin were also analyzed with broth microdilution method, live/dead staining, and SEM.Results: Cerium ions in the BMS underwent a transformation into cerium oxide nanoparticles, which were deposited in the inter- and intra-fibrillar collagen spaces through a meticulous bottom-up process. XPS analysis disclosed the presence of both Ce (III) and Ce (IV) of the generated cerium oxides. A comprehensive examination utilizing SEM and micro-CT identified the presence of cerium oxide nanoparticles deposited within the dentinal tubules and lateral canals of the root canal system. The BMS and remineralized dentin exhibited substantial antibacterial efficacy against E. faecalis, as substantiated by assessments involving the broth dilution method and live/dead staining technique. The SEM findings revealed the cell morphological changes of deceased E. faecalis.Conclusion: This study successfully demonstrated antibacterial biomimetic mineralization as well as sealing dentinal tubules and lateral branches of root canals using cerium nitrate and dextran. This novel biomimetic mineralization could be used as an alternative strategy for root canal disinfection.Keywords: cerium oxide, dextran, biomimetic mineralization, root canal disinfection
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- 2023
8. A Prospective Cohort Study of Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 as a Serologic Marker in Relation to Severity and Functional Outcome of Acute Intracerebral Hemorrhage
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Shentu HS, Chen YH, Cheng ZY, Fu B, Fu YH, Zheng SF, and Li C
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inter-alpha-trypsin inhibitor heavy chain 4 ,intracerebral hemorrhage ,early neurologic deterioration ,prognosis ,severity ,biomarkers ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Hua-Song Shentu,1 Yi-Hua Chen,1 Zhen-Yu Cheng,1 Bin Fu,1 Yuan-Hao Fu,1 Shu-Feng Zheng,2 Chan Li1 1Department of Neurosurgery, Jinhua People’s Hospital, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua, 321000, People’s Republic of China; 2Department of Endocrinology, Jinhua People’s Hospital, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua, 321000, People’s Republic of ChinaCorrespondence: Shu-Feng Zheng, Department of Endocrinology, Jinhua People’s Hospital, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua, 321000, People’s Republic of China, Email m13819976688@163.comBackground: The inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) may regulate immunity and inflammation. The current study was conducted to determine its role as a biomarker for reflecting the severity and predicting outcomes of intracerebral hemorrhage (ICH).Methods: In this prospective cohort study, 185 patients with supratentorial ICH were enrolled, among whom 62 had blood obtained not only at admission but also on days 1, 3, 5, 7, 10, and 14. In addition, 62 healthy controls underwent blood collection at the start of the study. The serum ITIH4 levels were then quantified. We recorded early neurological deterioration (END) and poor prognosis (modified Rankin Scale [mRS] scores of 3– 6]) six months after ICH.Results: Serum ITIH4 levels decreased prominently in the early phase after ICH, continued to decline until day 5, then gradually increased until day 14, and were significantly lower during 14 days in patients than in controls. Serum ITIH4 levels on admission were independently associated with serum C-reactive protein levels, National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volume. Admission serum ITIH4 levels were independently associated with mRS scores, END, and poor prognosis. No substantial differences existed in the areas under the receiver operating characteristic curve of END and poor prognosis prediction between the serum ITIH4 levels, NIHSS scores, and hematoma volume. Prediction models, in which serum ITIH4 levels, NIHSS scores, and hematoma volume were integrated, were relatively reliable and stable using a series of statistical methods. In addition, the prediction model of poor prognosis had a higher discriminatory ability than the NIHSS scores and hematoma volume alone.Conclusion: A dramatic decline in serum ITIH4 levels during the early period following ICH is independently related to the inflammatory response, stroke severity, and poor neurologic outcomes, suggesting that serum ITIH4 may be a useful prognostic biomarker of ICH.Keywords: inter-alpha-trypsin inhibitor heavy chain 4, intracerebral hemorrhage, early neurologic deterioration, prognosis, severity, biomarkers
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- 2023
9. Effects of simulated high-altitude living low-altitude training on the exercise abilities of adolescent boxers
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Wang, Y., Fu, B., and Gao, Y.
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- 2024
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10. Bibliometric and Visual Analysis in the Field of Dry Needling for Myofascial Pain Syndrome from 2000 to 2022
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Luo N, Li R, Fu B, Zeng Y, and Fang J
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dry needling ,myofascial pain syndrome ,bibliometric analysis ,research trends ,hotspots ,Medicine (General) ,R5-920 - Abstract
Ning Luo,1,* Rongrong Li,2,* Baitian Fu,1 Yichen Zeng,1 Jianqiao Fang1,2 1The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People’s Republic of China; 2Department of Acupuncture and Moxibustion, Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianqiao Fang, The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People’s Republic of China, Email fangjianqiao7532@163.comBackground: Evidence has shown that dry needling (DN) is effective for myofascial pain syndrome (MPS). However, bibliometrics has rarely been used to analyze the literature related to DN for MPS. The purpose of this study is to provide a systematic overview of global frontiers and research hotspots of DN in the treatment of MPS from 2000 to 2022.Methods: A search was conducted on Web of Science Core Collection (WoS CC) for literature on DN for MPS from 2000 to 2022. Based on the basic information provided by WoS CC, CiteSpace software was used to conduct bibliometric analysis of the countries, institutions, categories, journals, authors, references and keywords involved in this topic.Results: A total of 458 papers were obtained, with the number of publications increasing over time. Journal of Bodywork and Movement Therapies (31) was the most productive journal based on the number of publications, while Arch Phys Med Rehab (329) was the most co-cited journal. The most productive countries and institutions were USA (112) and Universidad Rey Juan Carlos (39), respectively. Fernandez-de-las-penas, Cesar has the highest number of publications (24) and Simons DG, who was an author with the highest number of citations (250). The article published by Gattie et al (co-citations: 65), and Mejuto-Vazquez et al (centrality: 0.36) were the most representative and symbolic. Based on the co-cited literature and keywords, myofascial trigger point, research methods, and acupuncture were the hot research topics and trends in the field.Conclusion: The current status and trends in clinical research of DN for MPS are revealed according to the results of this bibliometric study, which may facilitate researchers to identify hot topics and new directions for future research.Keywords: dry needling, myofascial pain syndrome, bibliometric analysis, research trends, hotspots
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- 2023
11. Many-objective bi-level energy scheduling method for integrated energy stations based on power allocation strategy
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Xiang Liao, Jun Ma, Bangli Yin, Beibei Qian, Runjie Lei, Fu B, and Chaoshun Li
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Energy systems ,Energy management ,Energy Modelling ,Science - Abstract
Summary: The integrated energy station of new energy vehicle hydrogenation/charging/power exchange is proposed, which also includes hydrogen production, hydrogen storage, electricity sales to users and the grid (WPIES). To address the efficiency of renewable energy use, this paper proposes a future value competition strategy for wind and photovoltaic (PV) allocation based on goal optimization (FVCS). In order to better realize the distribution of wind power/PV in the integrated energy station and improve the energy utilization efficiency of the integrated energy station, a two-layer optimization model of FVCS-WPIES is proposed, in which the upper layer model aims to maximize the expected income. The goals of the lower-level model are to maximize total profit, minimize battery losses, and minimize pollutant emissions. The model also considers the hydrogen power constraint and the upper-level model penalty. The comparison results show that the Pareto solution set is superior to the traditional model.
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- 2024
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12. Experimental evidence of crystal symmetry protection for the topological nodal line semimetal state in ZrSiS
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Gu, C. C., Hu, J., Chen, X. L., Guo, Z. P., Fu, B. T., Zhou, Y. H., An, C., Zhou, Y., Zhang, R. R., Xi, C. Y., Gu, Q. Y., Park, C., Shu, H. Y., Yang, W. G., Pi, L., Zhang, Y. H., Yao, Y. G., Yang, Z. R., Zhou, J. H., Sun, J., Mao, Z. Q., and Tian, M. L.
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Condensed Matter - Materials Science - Abstract
Tunable symmetry breaking plays a crucial role for the manipulation of topological phases of quantum matter. Here, through combined high-pressure magneto-transport measurements, Raman spectroscopy, and X-ray diffraction, we demonstrate a pressure-induced topological phase transition in nodal-line semimetal ZrSiS. Symmetry analysis and first-principles calculations suggest that this pressure-induced topological phase transition may be attributed to weak lattice distortions by non-hydrostatic compression, which breaks some crystal symmetries, such as the mirror and inversion symmetries. This finding provides some experimental evidence for crystal symmetry protection for the topological semimetal state, which is at the heart of topological relativistic fermion physics., Comment: 27 pages, 17 figures
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- 2019
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13. Decoupling of Lattice and Orbital Degrees of Freedom in an Iron-Pnictide Superconductor
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Matt, Christian E., Ivashko, O., Horio, M., Sutter, D., Dennler, N., Choi, J., Wang, Q., Fischer, M. H., Katrych, S., Forro, L., Ma, J., Fu, B., Lv, B., Zimmermann, M. v., Kim, T. K., Plumb, N. C., Xu, N., Shi, M., and Chang, J.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
The interplay of structural and electronic phases in iron-based superconductors is a central theme in the search for the superconducting pairing mechanism. While electronic nematicity, defined as the breaking of four-fold symmetry triggered by electronic degrees of freedom, is competing with superconductivity, the effect of purely structural orthorhombic order is unexplored. Here, using x-ray diffraction (XRD), we reveal a new structural orthorhombic phase with an exceptionally high onset temperature ($T_\mathrm{ort} \sim 250$ K), which coexists with superconductivity ($T_\mathrm{c} = 25$ K), in an electron-doped iron-pnictide superconductor far from the underdoped region. Furthermore, our angle-resolved photoemission spectroscopy (ARPES) measurements demonstrate the absence of electronic nematic order as the driving mechanism, in contrast to other underdoped iron pnictides where nematicity is commonly found. Our results establish a new, high temperature phase in the phase diagram of iron-pnictide superconductors and impose strong constraints for the modeling of their superconducting pairing mechanism., Comment: SI available upon request
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- 2019
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14. New classes of chiral topological nodes with non-contractible surface Fermi arcs in CoSi
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Rao, Z. -C., Li, H., Zhang, T. -T., Tian, S. -J., Li, C. -H., Fu, B. -B., Tang, C. -Y., Wang, L., Li, Z. -L., Fan, W. -H., Li, J. -J., Huang, Y. -B., Liu, Z. -H., Long, Y. -W., Fang, C., Weng, H. -M., Shi, Y. -G., Lei, H. -C., Sun, Y. -J., Qian, T., and Ding, H.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
In condensed matter systems, chiral topological nodes are robust band crossing points in momentum space that carry nonzero Chern numbers. The chirality is manifested by the presence of surface Fermi arcs connecting the projections of nodes with opposite Chern numbers. In addition to the well-known Weyl nodes, theorists have proposed several other types of chiral topological nodes in condensed matter systems, but the direct experimental evidence of their existence is still lacking. Here, using angle-resolved photoemission spectroscopy, we reveal two types of new chiral nodes, namely the spin-1 nodes and charge-2 Dirac nodes, at the band crossing points near the Fermi level in CoSi, the projections of which on the (001) surface are connected by topologically protected surface Fermi arcs. As these chiral nodes in CoSi are enforced at the Brillouin zone (BZ) center and corner by the crystalline symmetries, the surface Fermi arcs connecting their projections form a non-contractible path traversing the entire (001) surface BZ, in sharp contrast to pairs of Weyl nodes with small separation. Our work marks the first experimental observation of chiral topological nodes beyond the Weyl nodes both in the bulk and on the surface in condensed matter systems., Comment: This is the original version submitted to Nature on August 17, 2018. A revised version will appear in Nature
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- 2019
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15. Discovery of Weyl nodal lines in a single-layer ferromagnet
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Feng, B., Zhang, R. -W., Feng, Y., Fu, B., Wu, S., Miyamoto, K., He, S., Chen, L., Wu, K., Shimada, K., Okuda, T., and Yao, Y.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Two-dimensional (2D) materials have attracted great attention and spurred rapid development in both fundamental research and device applications. The search for exotic physical properties, such as magnetic and topological order, in 2D materials could enable the realization of novel quantum devices and is therefore at the forefront of materials science. Here, we report the discovery of two-fold degenerate Weyl nodal lines in a 2D ferromagnetic material, a single-layer gadolinium-silver compound, based on combined angle-resolved photoemission spectroscopy measurements and theoretical calculations. These Weyl nodal lines are symmetry protected and thus robust against external perturbations. The coexistence of magnetic and topological order in a 2D material is likely to inform ongoing efforts to devise and realize novel nanospintronic devices., Comment: 4 figures
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- 2019
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16. Modeling Water Quality in Watersheds: From Here to the Next Generation
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Fu, B, Horsburgh, JS, Jakeman, AJ, Gualtieri, C, Arnold, T, Marshall, L, Green, TR, Quinn, NWT, Volk, M, Hunt, RJ, Vezzaro, L, Croke, BFW, Jakeman, JD, Snow, V, and Rashleigh, B
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Hydrology ,Earth Sciences ,Engineering ,Civil Engineering ,Environmental Engineering ,water quality ,water quality models ,watershed management ,sediments ,nutrients ,data ,Physical Geography and Environmental Geoscience ,Civil engineering ,Environmental engineering - Abstract
In this synthesis, we assess present research and anticipate future development needs in modeling water quality in watersheds. We first discuss areas of potential improvement in the representation of freshwater systems pertaining to water quality, including representation of environmental interfaces, in-stream water quality and process interactions, soil health and land management, and (peri-)urban areas. In addition, we provide insights into the contemporary challenges in the practices of watershed water quality modeling, including quality control of monitoring data, model parameterization and calibration, uncertainty management, scale mismatches, and provisioning of modeling tools. Finally, we make three recommendations to provide a path forward for improving watershed water quality modeling science, infrastructure, and practices. These include building stronger collaborations between experimentalists and modelers, bridging gaps between modelers and stakeholders, and cultivating and applying procedural knowledge to better govern and support water quality modeling processes within organizations.
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- 2020
17. Comprehensive Analysis of the Expression, Prognosis, and Biological Significance of PLOD Family in Bladder Cancer
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Chen R, Jiang M, Hu B, Fu B, and Sun T
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bladder cancer ,plods ,immune infiltration ,prognosis ,biomarker ,Medicine (General) ,R5-920 - Abstract
Ru Chen,1,2,* Ming Jiang,1,* Bing Hu,1 Bin Fu,1 Ting Sun1 1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, People’s Republic of China; 2Department of Urology, the First Hospital of Putian City, Putian City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Fu; Ting Sun, Email urofbin@163.com; 361439919033@email.ncu.edu.cnBackground: Large numbers of studies have identified that procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family members play important roles in tumorigenesis and tumor progression in various cancers. However, the expression pattern, clinical value and function of PLOD family have yet to be analyzed systematically and comprehensively in bladder urothelial carcinoma (BLCA).Methods: We investigated the transcriptional levels, genetic alteration, biological function, immune cell infiltration, data on survival of PLODs in patients with BLCA based on UALCAN, the Cancer Genome Atlas (TCGA) database, Gene Expression Profiling Interactive Analysis (GEPIA), TIMER, STRING, cBioPortal and GSCALite databases. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed in R software using the Cluster Profiler Bioconductor package. Protein–protein interaction (PPI) network was established by STRING and visualized by using R version (3.6.3) software. Survival analysis was performed using the packages “survminer”.Results: The mRNA and protein expression patterns of PLOD family members were noticeably increased in BLC compared with normal tissue. The mRNA expression levels of PLOD1-2 genes were significantly correlated with histological subtypes and PLOD1 was significantly correlated with pathological stage. Furthermore, the high expression levels of PLOD1-2 were remarkably associated with poor overall survival (OS) in BLCA patients, meanwhile high expression levels of PLOD1 and PLOD3 were markedly associated with poor progression-free interval (PFI). In co-expression gene analysis, 50 genes were primarily associated with the differentially expressed PLODs in BLCA. Functional enrichment analysis revealed that protein hydroxylation, collagen fibril organization, and lysine degradation were key biological functions of PLODs in BLCA. Moreover, PLOD family genes were identified as being associated with the activities of tumor-infiltrating immune cells and closely associated with immune responses in BLCA.Conclusion: PLOD family members might serve as potential therapeutic targets and prognostic markers for BLCA patients’ survival.Keywords: bladder cancer, PLODs, immune infiltration, prognosis, biomarker
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- 2023
18. Polyoxometalate/MXene hybrid film with a 3D porous structure for high-performance electrochromic supercapacitors
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Chu, D., Qu, X., Zhang, S., Liu, Z., Wang, J., Zhou, L., Fu, B., Jin, H., and Yang, Y.
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- 2023
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19. Wavelength tunable soliton rains in a nanotube-mode locked Tm-doped fiber laser
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Fu, B., Popa, D., Zhao, Z., Hussain, S. A., Flahaut, E., Hasan, T., and Ferrari, A. C.
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Physics - Optics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
We report soliton rains in a tuneable Tm-doped fiber laser mode locked by carbon nanotubes. We also detect their second- and third-harmonic. We achieve a tuneability of over 56nm, from 1877 to 1933nm, by introducing a polarization-maintaining isolator and two in-line polarization controllers. This makes our system promising as a tuneable filter for ultrafast spectroscopy.
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- 2018
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20. Observation of a nodal chain with Dirac surface states in TiB2
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Yi, C. -J., Lv, B. Q., Wu, Q. S., Fu, B. -B., Gao, X., Yang, M., Peng, X. -L., Li, M., Huang, Y. -B., Richard, P., Shi, M., Li, G., Yazyev, Oleg V., Shi, Y. -G., Qian, T., and Ding, H.
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Condensed Matter - Materials Science - Abstract
Topological nodal-line semimetals (TNLSMs) are characterized by symmetry-protected band crossings extending along one-dimensional lines in momentum space. The nodal lines exhibit a variety of possible configurations, such as nodal ring, nodal link, nodal chain, and nodal knot. Here, using angle-resolved photoemission spectroscopy, we observe nodal rings in the orthogonal kz = 0 and kx = 0 planes of the Brillouin zone in TiB2. The nodal rings connect with each other on the intersecting line {\Gamma}-K of the orthogonal planes, forming a remarkable nodal-chain structure. Furthermore, we observe surface states (SSs) on the (001) cleaved surface, which are consistent with the calculated SSs considering the contribution from both Ti and B terminations. The calculated SSs have novel Dirac-cone-like band structures, which are distinct from the usual drumhead SSs with a single flat band proposed in other TNLSMs., Comment: 15 pages, 4 figures
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- 2018
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21. Incidence of Traumatic Sciatic Nerve Injury in Association with Acetabular Fracture: A Retrospective Observational Single-Center Study
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Liu Z, Fu B, Xu W, Liu F, Dong J, Li L, Zhou D, Hao Z, and Lu S
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acetabular fractures ,traumatic sciatic nerve injury ,posterior hip dislocation ,Medicine (General) ,R5-920 - Abstract
Zhigang Liu,1,2,* Baisheng Fu,2,* Weicheng Xu,2 Fanxiao Liu,2 Jinlei Dong,2 Lianxin Li,2 Dongsheng Zhou,2 Zhenhai Hao,2 Shun Lu2 1Department of Orthopaedics Surgery, Haining People’s Hospital, Jiaxing, People’s Republic of China; 2Department of Orthopaedics Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shun Lu, Department of Orthopaedics Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China, Tel +8618653189700, Email sdqdpdlushun@163.comPurpose: Traumatic sciatic nerve injury is one of the most serious consequences of acetabular fracture. However, reports on this type of injury are rare. In this study, we investigated the demographics of acetabular fracture with traumatic sciatic nerve injury, the clinical characteristics of patients with these injuries, and potential risk factors.Patients and Methods: We retrospectively reviewed patients diagnosed to have acetabular fracture at our trauma center between January 2014 and June 2021. Data on patient demographics, characteristics of the acetabular fracture, whether or not sciatic nerve injury occurred, types of sciatic nerve injury, and risk factors were analyzed.Results: A total of 195 patients met the diagnostic criteria for acetabular fractures. The average Injury Severity Score was 25.9 and the average Abbreviated Injury Scale score was 12.4. Road traffic accidents and falls from height were the main causes. Chest injuries and lower extremity fractures were the most common associated injuries. Posterior wall fractures were the most common fracture type. After exclusion of spinal cord and iatrogenic sciatic nerve injuries, 18 patients with acetabular fractures had traumatic sciatic nerve injury. Four of the 19 sides with traumatic sciatic nerve injury involved the common peroneal nerve division and 15 involved both the common peroneal and tibial nerve divisions. Logistic regression analysis identified a higher AIS score, posterior column fracture, and posterior hip dislocation to be predictors of traumatic sciatic nerve injury.Conclusion: Acetabular fractures were mostly high-energy injuries. Posterior wall fractures were the most common acetabular fracture types. Most patients sustained injury to the sciatic nerve as well as injury to the common peroneal and tibial nerve divisions. A higher AIS score, posterior column fracture, and posterior hip dislocation were predictors of acetabular fracture combined with traumatic sciatic nerve injury.Keywords: acetabular fractures, traumatic sciatic nerve injury, posterior hip dislocation
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- 2022
22. Observing Leadership as and in Networks: A Multilevel Investigation of Shared Leadership, Discrete Emotions, and Knowledge Behaviors
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Chen L, Yu G, and Fu B
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shared leadership ,pride ,fear of losing power ,knowledge sharing ,knowledge hiding ,social network approach ,Psychology ,BF1-990 ,Industrial psychology ,HF5548.7-5548.85 - Abstract
Lifang Chen,1 Guilan Yu,1 Bo Fu2 1School of Business and Management, Jilin University, Changchun, People’s Republic of China; 2School of Management, Guangzhou University, Guangzhou, People’s Republic of ChinaCorrespondence: Bo Fu, School of Management, Guangzhou University, No. 230 Wai Huan Road West, University City, Guangzhou, Guangdong, 510006, People’s Republic of China, Tel +86 188 0707 1295, Email fubo613@gzhu.edu.cnPurpose: With an increasing demand for shared leadership to address complex, dynamic, and diverse knowledge situations, more attention should be paid to the knowledge behaviors of emergent leaders in teams. However, there is thus far a lack of research into the multilevel nature of shared leadership. Using a dual network lens, this study considers two aspects of shared leadership: “shared leadership as networks” (SLAN) and “shared leadership in networks” (SLIN). Based on emotion appraisal theory, this study investigated the impact of SLIN on leaders’ productive and counterproductive knowledge behaviors through discrete emotions (pride and fear of losing power) and the moderating role of SLAN in guiding their emotions and subsequent behaviors.Methods: A social network approach was employed to obtain data among 431 employees from 72 teams in China. We identified 350 emergent leaders via leadership sociograms. Statistical analysis methods, including multilevel regression analysis, Monte Carlo simulation, and simple slope analysis, were utilized to test our hypotheses.Results: This study indicates that (1) SLIN is positively associated with pride (B = 0.33, p < 0.001), which in turn increases knowledge sharing (B = 0.37, p < 0.001); (2) SLIN is positively related to fear of losing power (B = 0.21, p < 0.05), which in turn is negatively associated with knowledge sharing (B = − 0.23, p < 0.001) and positively associated with knowledge hiding (B = 0.19, p < 0.001); (3) SLAN moderated these aforementioned indirect effects.Conclusion and Originality: First, by defining and differentiating between SLAN and SLIN, this study expands a new perspective on SLIN and facilitates the further development of multilevel shared leadership. Second, this study responds to recent calls for more research on leadership networks and individual-level outcomes of shared leadership. Moreover, it offers a novel theoretical framework to illustrate the impact of SLIN on their knowledge behaviors. Finally, the focus on the moderating role of SLAN identifies a significant contextual factor that prevents the dysfunctional effects of SLIN. These original discoveries enrich the literature on team leadership, emotions, and knowledge management. Further, our novel findings may be of interest to practitioners as they help organizations and teams manage the complex impacts of SLIN on knowledge behaviors in the contexts of an ongoing “affective revolution” and team-based organizational structures.Keywords: shared leadership, pride, fear of losing power, knowledge sharing, knowledge hiding, social network approach
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- 2022
23. The Resolution Rate of Pulmonary Embolism on CT Pulmonary Angiography: a Prospective Study
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Ak, M., Gumus, S., Aghayev, A., Chang, C.H., Fu, B., Roberts, M.S., Woodard, P.K., and Bae, K.T.
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- 2022
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24. Constructing a Prognostic Gene Signature for Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network Analysis and Single-Cell Analysis
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Fu B, Lu L, and Huang H
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single-cell rna sequencing ,lung adenocarcinoma ,intratumor heterogeneity ,molecular subtypes ,prognosis ,five-gene signature ,Medicine (General) ,R5-920 - Abstract
Biqian Fu,* Lin Lu,* Haifu Huang Internal Medicine-Oncology, Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haifu Huang, Internal Medicine-Oncology, Shenzhen Hospital of Guangzhou University of traditional Chinese Medicine, 6001 North Ring Road, Futian District, Shenzhen, 440300, People’s Republic of China, Tel +0755-83548611, Email huanghaifu2004@163.comPurpose: Lung adenocarcinoma (LUAD) has a high degree of intratumor heterogeneity. Advanced single-cell RNA sequencing (scRNA-seq) technologies have offered tools to analyze intratumor heterogeneity, which improves the accuracy of identifying biomarkers based on single-cell expression data, and thus helps in predicting prognosis of cancer patients and assisting decision-makings for cancer treatment.Patients and Methods: ScRNA-seq data containing two LUAD and two para-cancerous tissue samples were included to identify different cell clusters in tumor tissues. To identify the most relevant modules and important cell subpopulations (clusters) in LUAD tissues, weighted gene co-expression network analysis (WGCNA) was performed. Subsequently, LUAD molecular subtypes were constructed by unsupervised consensus clustering based on genes in key modules. Using differential analysis, univariate Cox regression analysis, and least absolute shrinkage and selection operator (LASSO) regression analysis, a prognostic model of LUAD was established.Results: A total of 14 cell clusters belonging to 10 cell types in LUAD were identified. The turquoise module was the most relevant to LUAD among all the modules; cluster 10 (C10, lung epithelial cells) was found to be the most strongly associated with the turquoise module. LUAD samples were divided into two groups of distinct molecular subtypes. Based on the 165 shared genes between the turquoise module and C10, 511 DEGs between the two molecular subtypes were obtained, and five of them were selected to construct the gene signature, which was validated to be an independent prognostic marker of LUAD.Conclusion: Fourteen cell clusters co-existed in LUAD, which contributed to its intratumor heterogeneity. Two molecular subtypes of LUAD were identified and a five-gene signature was developed and validated to be significantly associated with prognostic and clinical characteristics of LUAD patients.Keywords: single-cell RNA sequencing, lung adenocarcinoma, intratumor heterogeneity, molecular subtypes, prognosis, five-gene signature
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- 2022
25. Bioinformatic Analysis of the Expression and Clinical Significance of the DNA Replication Regulator MCM Complex in Bladder Cancer
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Chen R, Hu B, Jiang M, Deng W, Zheng P, and Fu B
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bladder cancer ,minichromosome maintenance complex ,bioinformatics ,potential biomarkers. ,Medicine (General) ,R5-920 - Abstract
Ru Chen,1,2,* Bing Hu,1,* Ming Jiang,1,* Wen Deng,1 Ping Zheng,3 Bin Fu1,4 1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Urology, The First Hospital of Putian City, Putian, Fujian, People’s Republic of China; 3Department of Urology, Shangrao municipal Hospital, Shangrao, 334000, Jiangxi Province, People’s Republic of China; 4Jiangxi Institute of Urology, Nanchang City, Jiangxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Fu, Email urofbin@163.comObjective: The minichromosome maintenance (MCM) complex (MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7), which regulates DNA replication and cell cycle progression, is essential for the development and progression of multiple tumors, but their role in bladder cancer development remains unclear. In the present study, the biological role and clinical significance of the MCM complex in bladder cancer were systematically elucidated.Materials and Methods: We analyzed DNA mutations, mRNA expression and protein levels, protein–protein interaction (PPI) networks, functional enrichment, prognostic value of MCM2/3/4/5/6/7 in bladder urothelial carcinoma (BLC) and the connections between the immune cell infiltration and the overall survival of BLC patients with the MCM expression levels using Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), the Cancer Genome Atlas database (TCGA), Human Protein Atlas, UALCAN, STRING, cBioPortal, TIMER and GSCALite databases.Results: The outcomes showed that the mRNA expression level of each member of the MCM complex was significantly correlated with histologic grade and tumor histology in BLC patients. Moreover, survival analysis showed that MCM/2/3/4/5/6/7 mRNA expressions were significantly associated with prognosis in patients with bladder cancer. Moreover, we experimentally validated the overexpression of the MCM2-7 complex in the BLC. Based on functional enrichment and PPI network analysis, the MCM complex might promote the progression of bladder cancer by activating DNA replication and accelerating cell cycle progression. In addition, MCM2/3/4/5/6/7 genes were also significantly associated with tumor immune cells infiltration and the drug sensitivity in BLC.Conclusion: Our study suggests that the MCM complex especially MCM2/4/6/7 might be potential molecular therapeutic targets for BLC treatment and might be useful biomarkers for diagnosis and prognosis.Keywords: bladder cancer, minichromosome maintenance complex, bioinformatics, potential biomarkers
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- 2022
26. Identification of KRBA1 as a Potential Prognostic Biomarker Associated with Immune Infiltration and m6A Modification in Hepatocellular Carcinoma
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Liu Y, Fu B, Yu Z, Song G, Zeng H, Gong Y, Ding Y, and Huang D
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krba1 ,prognosis ,biomarker ,immune infiltration ,hepatocellular carcinoma ,m6a modification ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Yue Liu,1,2 Bidong Fu,2 Zichuan Yu,2 Gelin Song,2 Hong Zeng,2 Yiyang Gong,2 Yongqi Ding,2 Da Huang3 1Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330000, People’s Republic of China; 2Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi Province, 330000, People’s Republic of China; 3Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330000, People’s Republic of ChinaCorrespondence: Da Huang, Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 13576113993, Email danmo0904@163.comPurpose: Hepatocellular carcinoma (HCC) is a malignancy with high incidence, but its prognosis is not optimistic. KRBA1 is a member of the KRAB family and participates in the regulation of gene transcription. However, no studies have focused on the role of KRBA1 in HCC.Patients and Methods: In this study, we first analyzed the expression of KRBA1 in HCC using TCGA and ICGC databases and validated by Immunohistochemistry in clinical HCC samples. The Wilcoxon rank-sum test was used to determine the relationship between KRBA1 expression and clinicopathological features. Subsequently, we used Kaplan-Meier online website analysis and Cox regression model to predict the prognostic value of KRBA1 in HCC patients. Furthermore, the functions of KRBA1 were identified by enrichment analysis. TIMER and GSCALite were used to investigate the relationship between KRBA1 expression in HCC and immune infiltration and drug targets, respectively. Finally, the relationship between KRBA1 expression and m6A modification in HCC was analyzed using the TCGA and ICGA datasets.Results: The results showed that KRBA1 was upregulated in HCC and was associated with many clinicopathological features. High KRBA1 causes poor overall survival and may be an independent risk factor for HCC. KRBA1 tends to be hypermethylated and associated with poor prognosis in HCC compared with normal tissues. Enrichment analysis indicates that KRBA1 is associated with cell cycle and immune processes, and TIMER analysis shows that KRBA1 expression is associated with infiltration levels and immune characteristics of various immune cells. Silenced KRBA1 evidently reduced three chemokine expression in HCC cells. Drug sensitivity analysis showed that KRBA1 was sensitive to 39 drug small molecules. KRBA1 showed a strong positive correlation with five m6A related genes.Conclusion: KRBA1 is a prognostic biomarker associated with HCC immunity and m6a modification, serving as an effective target for the diagnosis and treatment of HCC.Keywords: KRBA1, prognosis, biomarker, immune infiltration, hepatocellular carcinoma, m6A modification
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- 2022
27. Development and Validation of a Prognostic Nomogram for Predicting Overall Survival for T1 High-Grade Patients After Radical Cystectomy: A Study Based on SEER
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Zhan X, Chen L, Jiang M, and Fu B
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t1 high-grade ,seer ,nomogram ,prognosis ,radical cystectomy ,bladder cancer ,Medicine (General) ,R5-920 - Abstract
Xiangpeng Zhan, Luyao Chen, Ming Jiang, Bin Fu Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaCorrespondence: Bin Fu; Luyao Chen, Email urofbin@163.com; chenluyao301@163.comObjective: To construct a prognostic model that estimates the probability of overall survival for T1 high-grade bladder cancer patients after radical cystectomy.Patients and Methods: We enrolled 801 patients diagnosed with T1 high grade and received radical cystectomy from the Surveillance, Epidemiology, and End Results (SEER) database (2004– 2015). All patients were randomly divided into the development group (n = 561) and validation group (n = 240) with the ratio of 7:3. Cox proportional hazards regression analyses were used to filter variables and the Kaplan–Meier method to evaluate survival outcomes. The results of sensitivity analysis determined the variables in the final model. The performance of the model was internally validated by calibration curves, the receiver operating characteristic (ROC) curves, and the concordance index (C-index).Results: The mean survival months were 56.086 in the development group and 58.21 in the validation group. Six variables including age, marital status, tumour size, tumour sites, region nodes examined, and N stage were incorporated in the final nomogram. The accuracy of the nomogram for prediction of overall survival was estimated by C-index (0.732; 0.712– 0.752) and AUC (0.771 for 3-year; 0.766 for 5-year) in the development group. In the validation group, the C-index of the nomogram was 0.752 (0.723– 0.781), and AUC was 0.761 for 3-year as well as 0.793 for 5-year. These results all showed better performance than the AJCC stage. Calibration plots for 3- and 5-year overall survival presented good concordance in both the development and validation group.Conclusion: We have established a prognostic nomogram that provides a more accurate and relevant individualized probability of overall survival for patients with T1HG bladder transitional cell carcinoma after radical cystectomy. It can contribute to improving patient counselling and treatment selection.Keywords: T1 high-grade, SEER, nomogram, prognosis, radical cystectomy, bladder cancer
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- 2022
28. Observation of Open-Orbit Fermi Surface Topology in Extremely Large Magnetoresistance Semimetal MoAs$_2$
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Lou, R., Xu, Y. F., Zhao, L. -X., Han, Z. -Q., Guo, P. -J., Li, M., Wang, J. -C., Fu, B. -B., Liu, Z. -H., Huang, Y. -B., Richard, P., Qian, T., Liu, K., Chen, G. -F., Weng, H. M., Ding, H., and Wang, S. -C.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
While recent advances in band theory and sample growth have expanded the series of extremely large magnetoresistance (XMR) semimetals in transition metal dipnictides $TmPn_2$ ($Tm$ = Ta, Nb; $Pn$ = P, As, Sb), the experimental study on their electronic structure and the origin of XMR is still absent. Here, using angle-resolved photoemission spectroscopy combined with first-principles calculations and magnetotransport measurements, we performed a comprehensive investigation on MoAs$_2$, which is isostructural to the $TmPn_2$ family and also exhibits quadratic XMR. We resolve a clear band structure well agreeing with the predictions. Intriguingly, the unambiguously observed Fermi surfaces (FSs) are dominated by an open-orbit topology extending along both the [100] and [001] directions in the three-dimensional Brillouin zone. We further reveal the trivial topological nature of MoAs$_2$ by bulk parity analysis. Based on these results, we examine the proposed XMR mechanisms in other semimetals, and conclusively ascribe the origin of quadratic XMR in MoAs$_2$ to the carriers motion on the FSs with dominant open-orbit topology, innovating in the understanding of quadratic XMR in semimetals., Comment: 6 pages, 4 figures
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- 2017
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29. Identification of the Expression and Clinical Significance of E2F Family in Clear Cell Renal Cell Carcinoma
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Chen R, Zhang Z, Hu B, Jiang M, Zheng P, Deng W, Fu B, and Sun T
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clear cell renal cell carcinoma ,e2fs ,prognosis ,ualcan ,gepia ,Medicine (General) ,R5-920 - Abstract
Ru Chen,1,2,* Zhicheng Zhang,1,* Bing Hu,1,* Ming Jiang,1,* Ping Zheng,3 Wen Deng,1 Bin Fu,1,4 Ting Sun1,4 1Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang City, 330000, Jiangxi Province, People’s Republic of China; 2Department of Urology, The First Hospital of Putian City, Putian, 350001, Fujian, People’s Republic of China; 3Department of Urology, Shangrao municipal Hospital, Shangrao, 334000, Jiangxi Province, People’s Republic of China; 4Jiangxi Institute of Urology, Nanchang City, 330000, Jiangxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Fu; Ting Sun, Email urofbin@163.com; 361439919033@email.ncu.edu.cnBackground: Multiple studies have identified that E2F transcriptions act as important regulators for the tumorigenesis and progression of several human cancers. However, little is known about the function of E2Fs in clear cell renal cell carcinoma (ccRCC).Methods: We firstly investigated the expression levels, genetic alteration, and biological function of E2Fs in patients with ccRCC and the connections between the immune cell infiltration and the overall survivals of ccRCC patients with the E2Fs expression levels based on UALCAN, The Cancer Genome Atlas database, Gene Expression Profiling Interactive Analysis, TIMER, STRING, GSCALite and cBioPortal databases.Results: Results revealed that the expression levels of E2F1/2/3/4/6/7/8 were markedly upregulated in patients with ccRCC, while the expression of E2F5 displayed an opposite trend. We also experimentally validated the overexpression of E2F3/4/7 in human ccRCC tissues and ccRCC cell lines. Furthermore, the high E2F1/2/3/4/7/8 expression levels were clearly associated with worse pathological characteristics of ccRCC, including high pathological stage, poor molecular subtypes and high tumor grade. Meanwhile, high expression levels of E2F1/2/4/7/8 were evidently associated with worse overall survivals (OSs) and progression-free survivals (PFSs) of patients harboring ccRCC. Univariate and multivariate analyses illustrated that the expressions of E2F4/5/7 were independent factors associated with the OSs and PFSs of patients with ccRCC. Meanwhile, the mutations in E2Fs were also significantly related to poor OSs and PFSs of patients with ccRCC. Mechanically, the E2Fs genes synergistically promoted the progression of ccRCC by accelerating the cell cycle and inhibiting DNA damage response and apoptosis after performing the protein structure, functional enrichment, and PPI network analyses. In addition, E2Fs genes were also significantly associated with tumor immune cells infiltration and the drug sensitivity in ccRCC.Conclusion: As a result, E2F4/7 were highly expressed in ccRCC and significantly associated with worse pathological characteristics of ccRCC, including high pathological stage, poor molecular subtypes and high tumor grade, tumor immune cell infiltration, and drug sensitivity, consequently translating into poor OSs and PFSs of patients with ccRCC. Our results indicated that E2F4/7 could be potential biomarkers and therapeutic targets of ccRCC patients.Keywords: clear cell renal cell carcinoma, E2Fs, prognosis, UALCAN, GEPIA
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- 2022
30. Clinical and Computed Tomography Characteristics for Early Diagnosis of Peripheral Small-cell Lung Cancer
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Zhang X, Lv F, Fu B, Li W, Lin R, and Chu Z
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small-cell lung carcinoma ,non-small cell lung carcinoma ,tomography ,x-ray computed. ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Xiaochuan Zhang,1,2,* Fajin Lv,1,* Binjie Fu,1 Wangjia Li,1 Ruiyu Lin,1 Zhigang Chu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Radiology, Chonggang General Hospital, Chongqing, 400080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhigang Chu, Tel +86 18723032809, Fax +86 23 68811487, Email chuzg0815@163.comPurpose: To investigate the clinical and computed tomography (CT) characteristics of peripheral small-cell lung cancer (pSCLC) to improve its early diagnosis.Patients and Methods: In total, 70, 132, 69, and 95 patients with pathological confirmed nodular (≤ 3 cm) pSCLC, peripheral non-small cell lung cancer (pNSCLC), benign lung tumor (pBLT), and inflammatory lesion (pIL) were enrolled in this study retrospectively. The clinical and CT data of studied patients with different lesions were analyzed and compared by univariate analysis. Multivariate analysis was used to reveal the key features to distinguish pSCLC from pNSCLC, pBLT, and pIL, respectively.Results: Univariate and multivariate analysis of the clinical and CT characteristics of studied patients indicated that 1) compared with pNSCLC and pIL, vessel convergence, spiculation, and peripheral ground-glass opacity were less common in pSCLC; 2) density homogeneity (OR = 38.84– 120.21, P < 0.05), bronchial cutoff sign (OR = 10.00– 60.13, P = 0.001), hilar lymph node enlargement (OR = 22.81– 95.08, P < 0.0001) (pSCLC vs pNSCLC, pBLT, and pIL), male sex (OR = 5.53– 10.92, P < 0.05) (pSCLC vs pNSCLC and pBLT), and emphysema (OR = 36.57– 56.63, P < 0.05) (pSCLC vs pBLT and pIL) were significantly and independently associated with pSCLC. Type I and II bronchial cutoff sign, especially type I, were closely related to pSCLC.Conclusion: Peripheral solid nodules with homogeneous density, bronchial cutoff sign, hilar lymph node enlargement, but without spiculation or vessel convergence in male patients with emphysema should be highly suspected of pSCLC.Keywords: small-cell lung carcinoma, non-small cell lung carcinoma, tomography, X-ray computed
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- 2022
31. Role of Extrapancreatic Necrosis Volume in Assessing the Severity and Predicting the Outcomes of Severe Acute Pancreatitis
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Fu B, Feng H, Gao F, and Fu X
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acute pancreatitis ,acute necrotic collection ,ctsi ,ranson score ,Medicine (General) ,R5-920 - Abstract
Bao Fu,1,2,* Hui Feng,1,3,* Fei Gao,1,2 Xiaoyun Fu1,2 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, People’s Republic of China; 2Severe Acute Pancreatitis Diagnosis and Treatment Center of Guizhou Province, Zunyi City, Guizhou Province, People’s Republic of China; 3Department of Critical Care Medicine, Renhuai People’s Hospital, Renhuai City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyun FuDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian Road149, Zunyi City, Guizhou Province, People’s Republic of ChinaTel +8618108522207Fax +8685128608615Email zyyxyfxy@163.comObjective: To observe the relationship between the extrapancreatic necrosis volume and outcomes in patients with severe acute pancreatitis (SAP).Methods: We retrospectively analyzed 125 patients with SAP admitted to Severe Acute Pancreatitis Treatment Center of Guizhou Province from August 2013 to August 2018. All patients had extrapancreatic necrosis. The general clinical data of patients, C-reactive protein (CRP) value within 72 hours of onset, Ranson score, organ failure within 3 days after onset, complications, outcomes, CT severity index (CTSI), extrapancreatic necrosis volume and other information were collected. The correlation between extrapancreatic necrosis volume and hospitalization time, ICU stay, hospitalization cost, and CRP value was analyzed. The incidence of complications was obtained from the electronic medical record system.Results: The mean extrapancreatic necrosis volume was 680 ± 473 mL. The median length of hospital stay was 18.2 (3– 76) days, and the ICU stay was 13.5 (3– 66) days. The extrapancreatic necrosis volume was positively correlated with hospitalization time, ICU stay time, cost of hospitalization and CRP (P < 0.05). The extrapancreatic necrosis volume in organ failure group was significantly higher than that in non-organ failure group (P < 0.05). The extrapancreatic necrosis volume in patients with death was also higher than that in survival (P < 0.05). With the increase of extrapancreatic necrosis volume, the incidence of complications increased significantly. On the basis of extrapancreatic necrosis volume, the ROC curves yielded an AUC of 0.92 (95% CI: 0.83, 0.99) in predicting the mortality, which was higher than Ranson score (0.90, 95% CI 0.82– 0.96) and CTSI (0.85, 0 95% CI 0.77– 0.91).Conclusion: With the increase of extrapancreatic necrosis volume, the incidence of complications increased significantly. The extrapancreatic necrosis volume has the potential to be used as a valuable tool to predict the poor outcome of acute pancreatitis.Keywords: acute pancreatitis, acute necrotic collection, CTSI, Ranson score
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- 2021
32. The Role of Critical N6-Methyladenosine-Related Long Non-Coding RNAs and Their Correlations with Immune Checkpoints in Renal Clear Cell Carcinoma
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Deng W, Wang G, Deng H, Yan Y, Zhu K, Chen R, Liu X, Chen L, Zeng T, and Fu B
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immunotherapy ,n6-methylandenosine modification ,long non-coding rna ,renal cell carcinoma ,prognosis. ,Medicine (General) ,R5-920 - Abstract
Wen Deng,1,* Gongxian Wang,1,* Huanhuan Deng,2,* Yan Yan,3,* Ke Zhu,1,* Ru Chen,1,4 Xiaoqiang Liu,1 Luyao Chen,1 Tao Zeng,2 Bin Fu1 1Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 3Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 4Department of Urology, The First Hospital of Putian City, Putian City, Fujian Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Fu; Tao Zeng Tel + 86 13879103861; +86 18779101830Fax +86 0791-88698102; +86 0791-86120120Email urofbin@163.com; taozeng40709@sina.comPurpose: This study aimed to evaluate the functions of critical N6-methyladenosine (m6A)-related long non-coding RNAs (lncRNAs) and their correlations with immunotherapeutic targets in clear cell renal cell carcinoma (ccRCC).Methods: m6A-related lncRNAs were analyzed using the dataset from The Cancer Genome Atlas database via Pearson correlation analysis. Then, their prognostic functions in patients with ccRCC were determined via univariate Cox analysis. A prognostic m6A-related lncRNA signature (MRLS) in ccRCC was established using the least absolute shrinkage and selection operator (LASSO) Cox regression model. In addition, the correlations between these prognostic m6A-related lncRNAs with immune checkpoints were further evaluated in clinical samples.Results: MRLS was established by the LASSO Cox regression model on the basis of seven prognostic m6A-related lncRNAs. The risk score for each patient was calculated using the MRLS model, and the patients were further stratified into high- and low-risk subgroups. The MRLS model was validated with a robust prognostic ability by the stratification analysis. On the basis of age, grade, stage, and risk score, a nomogram was developed with a strong reliability in forecasting the overall survival percentages of the patients with ccRCC. Moreover, seven prognostic m6A-related lncRNAs enrolled in the MRLS model were found to be correlated with various immunotherapeutic targets, namely, PD-1, PD-L1, CTLA4, and LAG3, and the expression levels of which in the high-risk subgroup were significantly higher than those in the low-risk subgroup. The significant correlations between LINC00342 and the aforementioned immunotherapeutic targets were also confirmed in clinical samples.Conclusion: In this study, seven m6A-related lncRNAs were identified as potential biomarkers for forecasting the prognosis of patients with ccRCC and evaluating the efficacy of immunotherapy for these patients. Furthermore, a prognostic and predictive MRLS model with a high reliability was constructed to predict the overall survival probability of patients with ccRCC.Keywords: immunotherapy, N6-methyladenosine modification, long non-coding RNA, renal cell carcinoma, prognosis
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- 2021
33. Fluoxetine May Enhance VEGF, BDNF and Cognition in Patients with Vascular Cognitive Impairment No Dementia: An Open-Label Randomized Clinical Study
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Zhang L, Liu X, Li T, Xu B, and Fu B
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cognition ,enhancement ,neuroprotection ,selective serotonin reuptake inhibitors. ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Lei Zhang, Xuan Liu, Tong Li, Bing Xu, Binfang Fu Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, People’s Republic of ChinaCorrespondence: Xuan LiuDepartment of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, People’s Republic of ChinaTel +86 710 3524339Fax +86 710 3524330Email liuxuansk17@hotmail.comPurpose: Selective serotonin reuptake inhibitors (SSRIs) enhance angiogenesis and neurogenesis. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) play an important role in neurogenesis and angiogenesis. However, the effect of SSRIs on cognition and serum BDNF and VEGF in patients with vascular cognitive impairment no dementia (VCIND) is largely unknown.Patients and Methods: It was an open label study. Fifty VCIND patients were randomly allocated to receive fluoxetine (20 mg/d; n = 25) or no fluoxetine (control group; n = 25) for 12 weeks. VCIND patients received fluoxetine 20 mg/d and secondary prevention of stroke for 12 weeks in the fluoxetine group, whereas the control group received only secondary prevention of stroke for 12 weeks. The primary outcome and secondary outcome were of assessment of Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog) score, Ten Point Clock drawing test score (TPC), Verbal Fluency Test (VFT), Trail Making Test form a (TMTa), Trail Making Test form b (TMTb) and Digit Span Test score at baseline and week 12 in the both groups. And serum concentration of BDNF and VEGF was also tested at baseline and week 12 in both groups.Results: After 12 weeks, TPC scores increased more significantly in the fluoxetine group than in the control group, while TMTa score and TMTb score were decreased more significantly in the fluoxetine group than in the control group. We also found that the serum concentration of BDNF and VEGF in the fluoxetine group increased more significantly than in the control group. However, we found no significant differences in mean change from baseline between fluoxetine and control group in ADAS-Cog score, Digit Span Test score and VFT score.Conclusion: Fluoxetine may enhance cognition in certain cognitive domains and serum concentration of BDNF and VEGF in patients with VCIND.Keywords: cognition, enhancement, neuroprotection, selective serotonin reuptake inhibitors
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- 2021
34. A Hydroxypropyl Methylcellulose Film Loaded with AFCP Nanoparticles for Inhibiting Formation of Enamel White Spot Lesions
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Zhang Z, Shi Y, Zheng H, Zhou Z, Wu Z, Shen D, Wang Y, Zhang Y, Wang Z, and Fu B
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mineralizing film ,white spot lesions ,color ,micro-ct ,sem/edx ,nanoindentation ,Medicine (General) ,R5-920 - Abstract
Zhixin Zhang,* Ying Shi,* Haiyan Zheng, Zihuai Zhou, Zhifang Wu, Dongni Shen, Yiru Wang, Yizhou Zhang, Zhe Wang, Baiping Fu Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhe Wang; Baiping Fu Tel +86-571-87217427Fax +86-571-87217427Email 7319012@zju.edu.cn; fbp@zju.edu.cnObjective: This study investigated the effects of mineralizing film consisting of hydroxypropyl methylcellulose (HPMC) and amorphous fluorinated calcium phosphate (AFCP) nanoparticles on enamel white spot lesions (WSLs).Material and Methods: The AFCP nanoparticles and mineralizing film were prepared via nanoprecipitation and solvent evaporation, respectively. They were characterized with Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), inductively coupled plasma atomic emission spectrometry (ICP-AES), and fluoride ion selective electrode. Thirty-two human enamel slices (4 mm × 4 mm × 1.5 mm) were highly polished and randomly assigned to four groups: negative control (no treatment); pure HPMC film; mineralizing film; GC Tooth Mousse Plus® (contains 10% CPP-ACP and 0.2% NaF). Subsequently, samples were challenged by a modified pH-cycling and characterized by color measurement, Micro-CT, SEM/EDX, and nanoindentation.Results: The mineralizing film could sustain release of Ca, P and F ions over 24 h and maintain AFCP nanoparticles in metastable state over 8∼ 12 h. During 4 weeks of pH cycling, the mineralizing film group exhibited least color change (∆E), mineral loss and lesion depth (120 ± 10 μm) among four groups (p < 0.05). SEM findings revealed that the porosities among enamel crystals increased in negative control and pure HPMC film groups after pH cycling, whereas in mineralizing film group, the original microstructure of enamel was well conserved and mineral deposits were detected between enamel prisms. Mineralizing film group demonstrated a least reduction of nanomechanical properties such as elastic modulus of 77.02 ± 6.84 GPa and hardness of 3.62 ± 0.57 GPa (p < 0.05).Conclusion: The mineralizing film might be a promising strategy for prevention and management of WSLs via inhibiting enamel demineralization and promoting enamel remineralization.Keywords: mineralizing film, white spot lesions, color, micro-CT, SEM/EDX, nanoindentation
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- 2021
35. Evidence of topological insulator state in the semimetal LaBi
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Lou, R., Fu, B. -B., Xu, Q. N., Guo, P. -J., Kong, L. -Y., Zeng, L. -K., Ma, J. -Z., Richard, P., Fang, C., Huang, Y. -B., Sun, S. -S., Wang, Q., Wang, L., Shi, Y. -G., Lei, H. C., Liu, K., Weng, H. M., Qian, T., Ding, H., and Wang, S. -C.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
By employing angle-resolved photoemission spectroscopy combined with first-principles calculations, we performed a systematic investigation on the electronic structure of LaBi, which exhibits extremely large magnetoresistance (XMR), and is theoretically predicted to possess band anticrossing with nontrivial topological properties. Here, the observations of the Fermi-surface topology and band dispersions are similar to previous studies on LaSb [Phys. Rev. Lett. 117, 127204 (2016)], a topologically trivial XMR semimetal, except the existence of a band inversion along the $\Gamma$-$X$ direction, with one massless and one gapped Dirac-like surface state at the $X$ and $\Gamma$ points, respectively. The odd number of massless Dirac cones suggests that LaBi is analogous to the time-reversal $Z_2$ nontrivial topological insulator. These findings open up a new series for exploring novel topological states and investigating their evolution from the perspective of topological phase transition within the family of rare-earth monopnictides., Comment: 6 pages, 4 figures
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- 2016
- Full Text
- View/download PDF
36. ARPES observation of Mn-pnictide hybridization and negligible band structure renormalization in BaMn$_2$As$_2$ and BaMn$_2$Sb$_2$
- Author
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Zhang, W. -L., Richard, P., van Roekeghem, A., Nie, S. -M., Xu, N., Zhang, P., Miao, H., Wu, S. -F., Yin, J. -X., Fu, B. B., Kong, L. -Y., Qian, T., Wang, Z. -J., Fang, Z., Sefat, A. S., Biermann, S., and Ding, H.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We performed an angle-resolved photoemission spectroscopy study of BaMn$_2$As$_2$ and BaMn$_2$Sb$_2$, which are isostructural to the parent compound BaFe$_2$As$_2$ of the 122 family of ferropnictide superconductors. We show the existence of a strongly $k_z$-dependent band gap with a minimum at the Brillouin zone center, in agreement with their semiconducting properties. Despite the half-filling of the electronic 3$d$ shell, we show that the band structure in these materials is almost not renormalized from the Kohn-Sham bands of density functional theory. Our photon energy dependent study provides evidence for Mn-pnictide hybridization, which may play a role in tuning the electronic correlations in these compounds., Comment: 7 pages, 4 figures. See published version for the latest update
- Published
- 2016
- Full Text
- View/download PDF
37. Compensated semimetal LaSb with unsaturated magnetoresistance
- Author
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Zeng, L. -K., Lou, R., Wu, D. -S., Xu, Q. N., Guo, P. -J., Kong, L. -Y., Zhong, Y. -G., Ma, J. -Z., Fu, B. -B., Richard, P., Wang, P., Liu, G. T., Lu, L., Huang, Y. -B., Fang, C., Sun, S. -S., Wang, Q., Wang, L., Shi, Y. -G., Weng, H. M., Lei, H. -C., Liu, K., Wang, S. -C., Qian, T., Luo, J. -L., and Ding, H.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
By combining angle-resolved photoemission spectroscopy and quantum oscillation measurements, we performed a comprehensive investigation on the electronic structure of LaSb, which exhibits near-quadratic extremely large magnetoresistance (XMR) without any sign of saturation at magnetic fields as high as 40 T. We clearly resolve one spherical and one intersecting-ellipsoidal hole Fermi surfaces (FSs) at the Brillouin zone (BZ) center $\Gamma$ and one ellipsoidal electron FS at the BZ boundary $X$. The hole and electron carriers calculated from the enclosed FS volumes are perfectly compensated, and the carrier compensation is unaffected by temperature. We further reveal that LaSb is topologically trivial but share many similarities with the Weyl semimetal TaAs family in the bulk electronic structure. Based on these results, we have examined the mechanisms that have been proposed so far to explain the near-quadratic XMR in semimetals., Comment: 6 pages, 3 figures
- Published
- 2016
- Full Text
- View/download PDF
38. Observation of non-Fermi liquid behavior in hole-doped LiFe$_{1-x}$V$_x$As
- Author
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Xing, L. Y., Shi, X., Richard, P., Wang, X. C., Liu, Q. Q., Lv, B. Q., Ma, J. -Z., Fu, B. B., Kong, L. -Y., Miao, H., Qian, T., Kim, T. K., Hoesch, M., Ding, H., and Jin, C. Q.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We synthesized a series of V-doped LiFe$_{1-x}$V$_x$As single crystals. The superconducting transition temperature $T_c$ of LiFeAs decreases rapidly at a rate of 7 K per 1\% V. The Hall coefficient of LiFeAs switches from negative to positive with 4.2\% V doping, showing that V doping introduces hole carriers. This observation is further confirmed by the evaluation of the Fermi surface volume measured by angle-resolved photoemission spectroscopy (ARPES), from which a 0.3 hole doping per V atom introduced is deduced. Interestingly, the introduction of holes does not follow a rigid band shift. We also show that the temperature evolution of the electrical resistivity as a function of doping is consistent with a crossover from a Fermi liquid to a non-Fermi liquid. Our ARPES data indicate that the non-Fermi liquid behavior is mostly enhanced when one of the hole $d_{xz}/d_{yz}$ Fermi surfaces is well nested by the antiferromagnetic wave vector to the inner electron Fermi surface pocket with the $d_{xy}$ orbital character. The magnetic susceptibility of LiFe$_{1-x}$V$_x$As suggests the presence of strong magnetic impurities following V doping, thus providing a natural explanation to the rapid suppression of superconductivity upon V doping., Comment: 7 pages, 5 figures. See published version for the latest update
- Published
- 2016
- Full Text
- View/download PDF
39. Discovery of Weyl semimetal state violating Lorentz invariance in MoTe2
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Xu, N., Wang, Z. J., Weber, A. P., Magrez, A., Bugnon, P., Berger, H., Matt, C. E., Ma, J. Z., Fu, B. B., Lv, B. Q., Plumb, N. C., Radovic, M., Pomjakushina, E., Conder, K., Qian, T., Dil, J. H., Mesot, J., Ding, H., and Shi, M.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
A new type of Weyl semimetal state, in which the energy values of Weyl nodes are not the local extrema, has been theoretically proposed recently, namely type II Weyl semimetal. Distinguished from type I semimetal (e.g. TaAs), the Fermi surfaces in a type II Weyl semimetal consist of a pair of electron and hole pockets touching at the Weyl node. In addition, Weyl fermions in type II Weyl semimetals violate Lorentz invariance. Due to these qualitative differences distinct spectroscopy and magnetotransport properties are expected in type II Weyl semimetals. Here, we present the direct observation of the Fermi arc states in MoTe2 by using angle resolved photoemission spectroscopy. Two arc states are identified for each pair of Weyl nodes whoes surface projections of them possess single topological charge, which is a unique property for type II Weyl semimetals. The experimentally determined Fermi arcs are consistent with our first principle calculations. Our results unambiguously establish that MoTe2 is a type II Weyl semimetal, which serves as a great test bed to investigate the phenomena of new type of Weyl fermions with Lorentz invariance violated., Comment: 16 pages, 4 figures
- Published
- 2016
40. Emergence of topological bands on the surface of ZrSnTe crystal
- Author
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Lou, R., Ma, J. -Z., Xu, Q. -N., Fu, B. -B., Kong, L. -Y., Shi, Y. -G., Richard, P., Weng, H. -M., Fang, Z., Sun, S. -S., Wang, Q., Lei, H. -C., Qian, T., Ding, H., and Wang, S. -C.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
By using angle-resolved photoemission spectroscopy combined with first-principles calculations, we reveal that the topmost unit cell of ZrSnTe crystal hosts two-dimensional (2D) electronic bands of topological insulator (TI) state, though such a TI state is defined with a curved Fermi level instead of a global band gap. Furthermore, we find that by modifying the dangling bonds on the surface through hydrogenation, this 2D band structure can be manipulated so that the expected global energy gap is most likely to be realized. This facilitates the practical applications of 2D TI in heterostructural devices and those with surface decoration and coverage. Since ZrSnTe belongs to a large family of compounds having the similar crystal and band structures, our findings shed light on identifying more 2D TI candidates and superconductor-TI heterojunctions supporting topological superconductors., Comment: 5 pages, 4 figures
- Published
- 2016
- Full Text
- View/download PDF
41. Experimental evidence of large-gap two-dimensional topological insulator on the surface of ZrTe5
- Author
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Wu, R., Ma, J. -Z., Zhao, L. -X., Nie, S. -M., Huang, X., Yin, J. -X., Fu, B. -B., Richard, P., Chen, G. -F., Fang, Z., Dai, X., Weng, H. -M., Qian, T., Ding, H., and Pan, S. H.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Two-dimensional (2D) topological insulators (TIs) with a large bulk band-gap are promising for experimental studies of the quantum spin Hall effect and for spintronic device applications. Despite considerable theoretical efforts in predicting large-gap 2D TI candidates, only few of them have been experimentally verified. Here, by combining scanning tunneling microscopy/spectroscopy and angle-resolved photoemission spectroscopy, we reveal that the top monolayer of ZrTe5 crystals hosts a large band gap of ~100 meV on the surface and a finite constant density-of-states within the gap at the step edge. Our first-principles calculations confirm the topologically nontrivial nature of the edge states. These results demonstrate that the top monolayer of ZrTe5 crystals is a large-gap 2D TI suitable for topotronic applications at high temperature., Comment: 15 pages, 4 figures, submitted on Dec 31, 2015
- Published
- 2016
- Full Text
- View/download PDF
42. Equilibrium configuration of a bounded inextensible membrane subject to solar radiation pressure
- Author
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Fu, B, Farouki, RT, and Eke, FO
- Subjects
Solar sails ,Inextensible membranes ,Developable surfaces ,Elliptic integrals ,Numerical quadrature ,Boundary value problem ,Aerospace & Aeronautics ,Aerospace Engineering ,Mechanical Engineering - Abstract
The equilibrium shape of a thin inextensible membrane subject to solar radiation pressure under given boundary constraints is studied. The membrane is assumed to be insusceptible to elastic deformation and to have negligible bending resistance, and its steady-state shape is therefore described by a developable surface (i.e., a surface of zero Gaussian curvature), resulting from an equilibrium between radiation pressure and membrane tension forces. A quantitative understanding of the mechanics of such membranes is essential in characterizing the dynamics of solar sail spacecraft that use sail wing tip displacement as an attitude control mode. The analysis in this paper develops a theoretical foundation for the billowed wing shape. Under reasonable simplifying assumptions, the key result is that solar radiation pressure and a given wing tip displacement yield a billowed solar sail wing with the shape of a generalized cylinder (i.e., a developable ruled surface, whose rulings are all parallel, rather than a general developable with variable ruling directions). The base curve geometry for the solar sail is also determined as the solution to a boundary value problem. The results presented herein allow the shape of the billowed membrane to be computed to any desired precision, for any given tip displacement.
- Published
- 2017
43. High-spin structures in Xe 132 and Xe 133 and evidence for isomers along the N=79 isotones
- Author
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Vogt, A, Siciliano, M, Birkenbach, B, Reiter, P, Hadyńska-Klȩk, K, Wheldon, C, Valiente-Dobón, JJ, Teruya, E, Yoshinaga, N, Arnswald, K, Bazzacco, D, Blazhev, A, Bracco, A, Bruyneel, B, Chakrawarthy, RS, Chapman, R, Cline, D, Corradi, L, Crespi, FCL, Cromaz, M, De Angelis, G, Eberth, J, Fallon, P, Farnea, E, Fioretto, E, Fransen, C, Freeman, SJ, Fu, B, Gadea, A, Gelletly, W, Giaz, A, Görgen, A, Gottardo, A, Hayes, AB, Hess, H, Hetzenegger, R, Hirsch, R, Hua, H, John, PR, Jolie, J, Jungclaus, A, Karayonchev, V, Kaya, L, Korten, W, Lee, IY, Leoni, S, Liang, X, Lunardi, S, MacChiavelli, AO, Menegazzo, R, Mengoni, D, Michelagnoli, C, Mijatović, T, Montagnoli, G, Montanari, D, Müller-Gatermann, C, Napoli, D, Pearson, CJ, Podolyák, Z, Pollarolo, G, Pullia, A, Queiser, M, Recchia, F, Regan, PH, Régis, JM, Saed-Samii, N, Şahin, E, Scarlassara, F, Seidlitz, M, Siebeck, B, Sletten, G, Smith, JF, Söderström, PA, Stefanini, AM, Stezowski, O, Szilner, S, Szpak, B, Teng, R, Ur, C, Warner, DD, Wolf, K, Wu, CY, and Zell, KO
- Abstract
The transitional nuclei Xe132 and Xe133 are investigated after multinucleon-transfer (MNT) and fusion-evaporation reactions. Both nuclei are populated (i) in Xe136+Pb208 MNT reactions employing the high-resolution Advanced GAmma Tracking Array (AGATA) coupled to the magnetic spectrometer PRISMA, (ii) in the Xe136+Pt198 MNT reaction employing the GAMMASPHERE spectrometer in combination with the gas-detector array CHICO, and (iii) as an evaporation residue after a Te130(α,xn)Xe134-xn fusion-evaporation reaction employing the HORUS γ-ray array at the University of Cologne. The high-spin level schemes are considerably extended above the Jπ=(7-) and (10+) isomers in Xe132 and above the 11/2- isomer in Xe133. The results are compared to the high-spin systematics of the Z=54 as well as the N=78 and N=79 chains. Furthermore, evidence is found for a long-lived (T1/2â‰1μs) isomer in Xe133 which closes a gap along the N=79 isotones. Shell-model calculations employing the SN100PN and PQM130 effective interactions reproduce the experimental findings and provide guidance to the interpretation of the observed high-spin features.
- Published
- 2017
44. High-spin structures in Xe132 and Xe133 and evidence for isomers along the N=79 isotones
- Author
-
Vogt, A, Siciliano, M, Birkenbach, B, Reiter, P, Hadyńska-Klęk, K, Wheldon, C, Valiente-Dobón, JJ, Teruya, E, Yoshinaga, N, Arnswald, K, Bazzacco, D, Blazhev, A, Bracco, A, Bruyneel, B, Chakrawarthy, RS, Chapman, R, Cline, D, Corradi, L, Crespi, FCL, Cromaz, M, de Angelis, G, Eberth, J, Fallon, P, Farnea, E, Fioretto, E, Fransen, C, Freeman, SJ, Fu, B, Gadea, A, Gelletly, W, Giaz, A, Görgen, A, Gottardo, A, Hayes, AB, Hess, H, Hetzenegger, R, Hirsch, R, Hua, H, John, PR, Jolie, J, Jungclaus, A, Karayonchev, V, Kaya, L, Korten, W, Lee, IY, Leoni, S, Liang, X, Lunardi, S, Macchiavelli, AO, Menegazzo, R, Mengoni, D, Michelagnoli, C, Mijatović, T, Montagnoli, G, Montanari, D, Müller-Gatermann, C, Napoli, D, Pearson, CJ, Podolyák, Zs, Pollarolo, G, Pullia, A, Queiser, M, Recchia, F, Regan, PH, Régis, J-M, Saed-Samii, N, Şahin, E, Scarlassara, F, Seidlitz, M, Siebeck, B, Sletten, G, Smith, JF, Söderström, P-A, Stefanini, AM, Stezowski, O, Szilner, S, Szpak, B, Teng, R, Ur, C, Warner, DD, Wolf, K, Wu, CY, and Zell, KO
- Subjects
Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
The transitional nuclei Xe132 and Xe133 are investigated after multinucleon-transfer (MNT) and fusion-evaporation reactions. Both nuclei are populated (i) in Xe136+Pb208 MNT reactions employing the high-resolution Advanced GAmma Tracking Array (AGATA) coupled to the magnetic spectrometer PRISMA, (ii) in the Xe136+Pt198 MNT reaction employing the GAMMASPHERE spectrometer in combination with the gas-detector array CHICO, and (iii) as an evaporation residue after a Te130(α,xn)Xe134-xn fusion-evaporation reaction employing the HORUS γ-ray array at the University of Cologne. The high-spin level schemes are considerably extended above the Jπ=(7-) and (10+) isomers in Xe132 and above the 11/2- isomer in Xe133. The results are compared to the high-spin systematics of the Z=54 as well as the N=78 and N=79 chains. Furthermore, evidence is found for a long-lived (T1/2â‰1μs) isomer in Xe133 which closes a gap along the N=79 isotones. Shell-model calculations employing the SN100PN and PQM130 effective interactions reproduce the experimental findings and provide guidance to the interpretation of the observed high-spin features.
- Published
- 2017
45. Isomers and high-spin structures in the N=81 isotones Xe 135 and Ba 137
- Author
-
Vogt, A, Birkenbach, B, Reiter, P, Blazhev, A, Siciliano, M, Hadyńska-Klȩk, K, Valiente-Dobón, JJ, Wheldon, C, Teruya, E, Yoshinaga, N, Arnswald, K, Bazzacco, D, Bowry, M, Bracco, A, Bruyneel, B, Chakrawarthy, RS, Chapman, R, Cline, D, Corradi, L, Crespi, FCL, Cromaz, M, De Angelis, G, Eberth, J, Fallon, P, Farnea, E, Fioretto, E, Freeman, SJ, Fu, B, Gadea, A, Geibel, K, Gelletly, W, Gengelbach, A, Giaz, A, Görgen, A, Gottardo, A, Hayes, AB, Hess, H, Hirsch, R, Hua, H, John, PR, Jolie, J, Jungclaus, A, Kaya, L, Korten, W, Lee, IY, Leoni, S, Lewandowski, L, Liang, X, Lunardi, S, Macchiavelli, AO, Menegazzo, R, Mengoni, D, Michelagnoli, C, Mijatović, T, Montagnoli, G, Montanari, D, Müller-Gatermann, C, Napoli, D, Pearson, CJ, Pellegri, L, Podolyák, Z, Pollarolo, G, Pullia, A, Queiser, M, Radeck, F, Recchia, F, Regan, PH, Rosiak, D, Saed-Samii, N, Şahin, E, Scarlassara, F, Schneiders, D, Seidlitz, M, Siebeck, B, Sletten, G, Smith, JF, Söderström, PA, Stefanini, AM, Steinbach, T, Stezowski, O, Szilner, S, Szpak, B, Teng, R, Ur, C, Vandone, V, Warner, DD, Wiens, A, Wu, CY, and Zell, KO
- Abstract
The high-spin structures and isomers of the N=81 isotones Xe135 and Ba137 are investigated after multinucleon-transfer (MNT) and fusion-evaporation reactions. Both nuclei are populated (i) in Xe136+U238 and (ii) Xe136+Pb208 MNT reactions employing the high-resolution Advanced Gamma Tracking Array (AGATA) coupled to the magnetic spectrometer PRISMA, (iii) in the Xe136+Pt198 MNT reaction employing the γ-ray array GAMMASPHERE in combination with the gas-detector array CHICO, and (iv) via a B11+Te130 fusion-evaporation reaction with the HORUS γ-ray array at the University of Cologne. The high-spin level schemesof Xe135 and Ba137 are considerably extended to higher energies. The 2058-keV (19/2-) state in Xe135 is identified as an isomer, closing a gap in the systematics along the N=81 isotones. Its half-life is measured to be 9.0(9) ns, corresponding to a reduced transition probability of B(E2,19/2-→15/2-)=0.52(6) W.u. The experimentally deduced reduced transition probabilities of the isomeric states are compared to shell-model predictions. Latest shell-model calculations reproduce the experimental findings generally well and provide guidance to the interpretation of the new levels.
- Published
- 2017
46. Isomers and high-spin structures in the N=81 isotones Xe135 and Ba137
- Author
-
Vogt, A, Birkenbach, B, Reiter, P, Blazhev, A, Siciliano, M, Hadyńska-Klęk, K, Valiente-Dobón, JJ, Wheldon, C, Teruya, E, Yoshinaga, N, Arnswald, K, Bazzacco, D, Bowry, M, Bracco, A, Bruyneel, B, Chakrawarthy, RS, Chapman, R, Cline, D, Corradi, L, Crespi, FCL, Cromaz, M, de Angelis, G, Eberth, J, Fallon, P, Farnea, E, Fioretto, E, Freeman, SJ, Fu, B, Gadea, A, Geibel, K, Gelletly, W, Gengelbach, A, Giaz, A, Görgen, A, Gottardo, A, Hayes, AB, Hess, H, Hirsch, R, Hua, H, John, PR, Jolie, J, Jungclaus, A, Kaya, L, Korten, W, Lee, IY, Leoni, S, Lewandowski, L, Liang, X, Lunardi, S, Macchiavelli, AO, Menegazzo, R, Mengoni, D, Michelagnoli, C, Mijatović, T, Montagnoli, G, Montanari, D, Müller-Gatermann, C, Napoli, D, Pearson, CJ, Pellegri, L, Podolyák, Zs, Pollarolo, G, Pullia, A, Queiser, M, Radeck, F, Recchia, F, Regan, PH, Rosiak, D, Saed-Samii, N, Şahin, E, Scarlassara, F, Schneiders, D, Seidlitz, M, Siebeck, B, Sletten, G, Smith, JF, Söderström, P-A, Stefanini, AM, Steinbach, T, Stezowski, O, Szilner, S, Szpak, B, Teng, R, Ur, C, Vandone, V, Warner, DD, Wiens, A, Wu, CY, and Zell, KO
- Subjects
Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
The high-spin structures and isomers of the N=81 isotones Xe135 and Ba137 are investigated after multinucleon-transfer (MNT) and fusion-evaporation reactions. Both nuclei are populated (i) in Xe136+U238 and (ii) Xe136+Pb208 MNT reactions employing the high-resolution Advanced Gamma Tracking Array (AGATA) coupled to the magnetic spectrometer PRISMA, (iii) in the Xe136+Pt198 MNT reaction employing the γ-ray array GAMMASPHERE in combination with the gas-detector array CHICO, and (iv) via a B11+Te130 fusion-evaporation reaction with the HORUS γ-ray array at the University of Cologne. The high-spin level schemesof Xe135 and Ba137 are considerably extended to higher energies. The 2058-keV (19/2-) state in Xe135 is identified as an isomer, closing a gap in the systematics along the N=81 isotones. Its half-life is measured to be 9.0(9) ns, corresponding to a reduced transition probability of B(E2,19/2-→15/2-)=0.52(6) W.u. The experimentally deduced reduced transition probabilities of the isomeric states are compared to shell-model predictions. Latest shell-model calculations reproduce the experimental findings generally well and provide guidance to the interpretation of the new levels.
- Published
- 2017
47. Observation of high-Tc superconductivity in rectangular FeSe/STO(110) monolayer
- Author
-
Zhang, P., Peng, X. -L., Qian, T., Richard, P., Shi, X., Ma, J. -Z., Fu, B. -B., Guo, Y. -L., Han, Z. Q., Wang, S. C., Wang, L. L., Xue, Q. -K., Hu, J. P., Sun, Y. -J., and Ding, H.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
It is well known that superconductivity in Fe-based materials is favoured under tetragonal symmetry, whereas competing orders such as spin-density-wave (SDW) and nematic orders emerge or are reinforced upon breaking the fourfold (C4) symmetry. Accordingly, suppression of orthorhombicity below the superconducting transition temperature (Tc) is found in underdoped compounds. Epitaxial film growth on selected substrates allows the design of crystal specific lattice distortions. Here we show that despite the breakdown of the C4 symmetry induced by a 5% difference in the lattice parameters, monolayers of FeSe grown by molecular beam epitaxy (MBE) on the (110) surface of SrTiO3 (STO) substrates [FeSe/STO(110)] exhibit a large nearly isotropic superconducting (SC) gap of 16 meV closing around 60 K. Our results on this new interfacial material, similar to those obtained previously on FeSe/STO(001), contradict the common belief that the C4 symmetry is essential for reaching high Tc's in Fe-based superconductors.
- Published
- 2015
- Full Text
- View/download PDF
48. Observation of two distinct $d_{xz}/d_{yz}$ band splittings in FeSe
- Author
-
Zhang, P., Qian, T., Richard, P., Wang, X. P., Miao, H., Lv, B. Q., Fu, B. B., Wolf, T., Meingast, C., Wu, X. X., Wang, Z. Q., Hu, J. P., and Ding, H.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We report the temperature evolution of the detailed electronic band structure in FeSe single-crystals measured by angle-resolved photoemission spectroscopy (ARPES), including the degeneracy removal of the $d_{xz}$ and $d_{yz}$ orbitals at the $\Gamma$/Z and M points, and the orbital-selective hybridization between the $d_{xy}$ and $d_{xz/yz}$ orbitals. The temperature dependences of the splittings at the $\Gamma$/Z and M points are different, indicating that they are controlled by different order parameters. The splitting at the M point is closely related to the structural transition and is attributed to orbital ordering defined on Fe-Fe bonds with a $d$-wave form in the reciprocal space that breaks the rotational symmetry. In contrast, the band splitting at the $\Gamma$ points remains at temperature far above the structural transition. Although the origin of this latter splitting remains unclear, our experimental results exclude the previously proposed ferro-orbital ordering scenario., Comment: 5 pages, 3 figures. New title. Abstract and introduction modified
- Published
- 2015
- Full Text
- View/download PDF
49. Experimental discovery of Weyl semimetal TaAs
- Author
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Lv, B. Q., Weng, H. M., Fu, B. B., Wang, X. P., Miao, H., Ma, J., Richard, P., Huang, X. C., Zhao, L. X., Chen, G. F., Fang, Z., Dai, X., Qian, T., and Ding, H.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Weyl semimetals are a class of materials that can be regarded as three-dimensional analogs of graphene breaking time reversal or inversion symmetry. Electrons in a Weyl semimetal behave as Weyl fermions, which have many exotic properties, such as chiral anomaly and magnetic monopoles in the crystal momentum space. The surface state of a Weyl semimetal displays pairs of entangled Fermi arcs at two opposite surfaces. However, the existence of Weyl semimetals has not yet been proved experimentally. Here we report the experimental realization of a Weyl semimetal in TaAs by observing Fermi arcs formed by its surface states using angle-resolved photoemission spectroscopy. Our first-principles calculations, matching remarkably well with the experimental results, further confirm that TaAs is a Weyl semimetal., Comment: 14 pages, 4 figures, see also theoretical paper on TaAs arXiv:1501.00060
- Published
- 2015
- Full Text
- View/download PDF
50. Shear behavior of reinforced concrete beams with GFRP needles
- Author
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Nie, X.F., Fu, B., Teng, J.G., Bank, L.C., and Tian, Y.
- Published
- 2020
- Full Text
- View/download PDF
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