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Background Pediatricians often receive inconsistent reports from parents and teachers on children's behavior, but there are few available studies on comparing parents and teachers' evaluation of preschool children's behavior problems. Objective To investigate the prevalence of behavioral problems in preschoolers from Chongqing's main urban areas, and to explore the consistency and discrepancy between parents- and teachers-assessed behavioral problems in these children. Methods In June 2018, 2 698 preschoolers were sampled by cluster sampling from kindergartens in the main urban area of Chongqing. For understanding the prevalence of behavioral problems in them, their behaviors were rated by their parents using the Conners Parent Symptom Questionnaire (PSQ) , and by their teachers using the Conners Teacher Rating Scale (TRS) . And parents- and teachers-assessed results were compared. Results The survey obtained a response rate of 98.59%, involving 2 660 children that were finally included. In accordance with parents' assessment, the prevalence of behavioral problems was 14.47% in preschool children (385/2 660) , and that in boys was higher than in girls〔17.91% (245/1 368) vs 10.84% (140/1 292) , P0.05) . Conclusion The prevalence of behavior problems in preschoolers assessed by parents was higher than that assessed by teachers. Although there are some differences between the assessment by parents and teachers, there is a good consistency in their assessment of conduct problems and hyperactivity.

Background: Birth weight is of importance due to its relation to fetal health, and it's also a predictor of the subsequent development of the child., Objective: This study aims to assess whether betaine is associated with poor fetal growth., Design: A case-control study was used in this study., Setting: The study took place at the Chongqing Maternal and Child Health Hospital, in Chong Qing, China., Participants: A total of 141mother-infant pairs were recruited from the Department of Obstetrics of our hospital between June 2021 and December 2021. According to gestational age and birth weight, themother-infant pairs were divided into small-for-gestational-age and appropriate-for-gestational-age groups., Primary Outcome Measures: Cord plasma concentrations of betaine were measured by high-performance liquid chromatography tandem mass spectrometry. Plasma levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were determined using commercially available assays on an automatic biochemical analyzer (BS-240 VET, Mindray Medical, Shenzhen, China) using reagent from Mindray Medical company., Results: Cord plasma betaine concentrations were higher in small-for-gestational-age relative to appropriate-for-gestational-age newborns, and were not correlated to lipid levels. Adjusting for maternal and neonatal characteristics, birth weight and birth length were negatively correlated with the levels of betaine. Higher betaine concentrations were associated with increased risks of small-for-gestational-age., Conclusions: Elevated cord blood betaine concentration was independently associated with a higher risk of small-for-gestational-age infants, suggesting that betaine dysregulation may be a risk factor for impaired fetal growth.

Background: Vitamin D is closely related to childhood allergic diseases, such as food allergies, atopic dermatitis, and asthma. However, it is unclear whether vitamin D status in the cord blood from mothers is related to food allergies in infants., Objective: We performed a prospective cohort study on the relationship between the cord blood vitamin D [i.e., 25-hydroxyvitamin D3(25(OH)D3)] level and infant food allergies., Methods: This study selected 741 newborns to observe until 6 months of age and used open oral food challenges (OFCs) to diagnose their food allergies. Cord blood and 6-month serum 25(OH)D3 levels of the infants were measured by liquid chromatography-tandem mass spectrometry., Results: The proportion of children with cord blood 25(OH)D3 deficiency (< 20 ng/mL) was 86.27%. Cord blood vitamin D was positively correlated with the supplementation frequency of egg yolk, multivitamins, calcium, and docosahexaenoic acid (DHA) during pregnancy and the mother's age. No significant difference was found in the cord blood 25(OH)D3 level between summer born and winter born infants (p = 0.465). After adjusting for seasonal factors, the risk of food allergies in the 25(OH)D3 non-deficiency group was 2.72 times that of the 25(OH)D3 deficiency group. Infants in the 25(OH)D3 non-deficiency group ≥20 ng/mL) had a higher risk of allergies compared with the deficiency group (< 20 ng/mL) (RR = 2.49)., Conclusions: Cord blood 25(OH)D3 is associated with infant food allergies. Maintaining 25(OH)D3 in maternal cord blood at a low level may be conducive to the prevention of infant food allergies.

Objective: To understand the infantile nocturnal sleep-wake pattern developmental trajectory with Actiwatch, which would benefit the clinical assessment of infantile sleep., Method: This study was a longitudinal study conducted between 7 Oct, 2009-30 Oct, 2011 in 10 hospitals of 9 cities of China ( Beijing, Xi'an, Qingdao, Wuhan, Changsha, Chongqing, Huzhou, Xiamen and Liuzhou). Actiwatch was used to track the sleep-wake pattern development trajectory of healthy infants in the first year of life in the home setting. Participating infants were followed up at 10th day and 28th day during the first month, and then monthly from the second to the sixth month after birth, and then at ninth and twelve months of age respectively. Meanwhile, infantile sleep was observed continuously for about 60 hours at each visit. According to the characteristics of repeated measurement data of this study, two-level random effect model was adopted to analyze the trend of infantile nocturnal sleep-wake parameters changing with age, and the gender difference., Result: A total of 473 healthy infants were included in this study, among whom 246 (52.0%) were boys, and 227 (48.0%) were girls; 355 (75.1%) infants completed the whole year follow-up survey. With infants' age increasing, the latency of infants' nighttime sleep onset decreased from 66.8 minutes on 10th day to 15.5-18.7 minutes at 6-12 months of age. The number of night wakes also decreased with age, while uninterrupted sleep periods lengthened with age. On the 10th day, there were 3.0 times of nightwaking on average, and the longest continuous sleeping interval lasted for 227.6 minutes on average. At 12-month of age, infants could sleep continuously for 350.9 minutes at most on average, while the number of nightwaking decreased to 1.6 times per night on average. Generally, nighttime sleep efficiency increased from 66.3% on the 10th day to 86.3% at 12-month of age. The differences of sleep-wake patterns between boys and girls presented as boys' nocturnal longest uninterrupted sleep period was 19 minutes shorter(266.6 vs. 285.6 min), and the average nighttime sleep efficiency was 2.2% lower (74.2% vs. 76.4%) compared with girls respectively. And the differences of sleep efficiency between boys and girls reduced gradually along with the growth., Conclusion: During the first 6 months after birth, infantile sleep-wake pattern undergo obvious change. The capability of sleep-onset and uninterrupted sleep improved with age, and the sleep efficiency increased.