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27 results on '"von Stebut, Jennifer"'

2. Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Author

Dorado García, Heathcliff, Pusch, Fabian, Bei, Yi, von Stebut, Jennifer, Ibáñez, Glorymar, Guillan, Kristina, Imami, Koshi, Gürgen, Dennis, Rolff, Jana, Helmsauer, Konstantin, Meyer-Liesener, Stephanie, Timme, Natalie, Bardinet, Victor, Chamorro González, Rocío, MacArthur, Ian C., Chen, Celine Y., Schulz, Joachim, Wengner, Antje M., Furth, Christian, Lala, Birgit, Eggert, Angelika, Seifert, Georg, Hundsoerfer, Patrick, Kirchner, Marieluise, Mertins, Philipp, Selbach, Matthias, Lissat, Andrej, Dubois, Frank, Horst, David, Schulte, Johannes H., Spuler, Simone, You, Daoqi, Dela Cruz, Filemon, Kung, Andrew L., Haase, Kerstin, DiVirgilio, Michela, Scheer, Monika, Ortiz, Michael V., and Henssen, Anton G.

Published
2022
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3. Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real‐world evidence of about 500,000 patients.

Author

von Stebut, Jennifer, Heiland, Max, Preissner, Robert, Rendenbach, Carsten, and Preissner, Saskia

Subjects
*HERPES simplex, *HERPES simplex virus, *PROPENSITY score matching, *VIRUS diseases, *ORAL cancer, *HEAD & neck cancer
Abstract

Background: The role of viral agents in the development of head and neck cancers has remained controversial. While markers of viral origin have been isolated from oral cancer tissues, a causative relationship has yet to be shown. The aim of this study was to evaluate the relationship between head and neck cancers and Herpes simplex virus, one of the most common viral infections of the oral orifice. Methods: Here, we conducted a retrospective analysis of two age‐ and gender‐matched cohorts extracted from the real‐world database TriNetX on March 10th, 2023, each consisting of 249,272 patients with and without Herpes simplex infections (ICD‐10: B00). The diagnoses C00‐C14 were analyzed, and risk analysis and Kaplan‐Meier survival statics were computed. Results: The strongest association was found for lip cancer (ICD‐10: C00) with a hazard ratio [HR (CI 95% low‐high)] of 3.08 (1.77–5.35). A significant association with HR of 1.17 (1.02–1.34) was found for the entire group of head and neck cancers. Confounders like smoking and alcohol dependence were considered using propensity score matching. Conclusion: The surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Supplementary Table 2 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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5. Supplementary Figure 6 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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6. Supplementary Figure 9 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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7. Supplementary Figure 11 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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8. Supplementary Figure 5 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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9. Supplementary Figure 7 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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10. Supplementary Figure 4 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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11. Supplementary Figure 2 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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12. Supplementary Figure 8 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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13. Supplementary Table 1 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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14. Supplementary Table 7 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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15. Supplementary Table 4 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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16. Supplementary Table 3 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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17. Data from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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18. Supplementary Table 5 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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19. Supplementary Table 6 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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20. Supplementary Figure 3 from Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models

Author

Pusch, Fabian F., primary, Dorado García, Heathcliff, primary, Xu, Robin, primary, Gürgen, Dennis, primary, Bei, Yi, primary, Brückner, Lotte, primary, Röefzaad, Claudia, primary, von Stebut, Jennifer, primary, Bardinet, Victor, primary, Chamorro Gonzalez, Rocío, primary, Eggert, Angelika, primary, Schulte, Johannes H., primary, Hundsdörfer, Patrick, primary, Seifert, Georg, primary, Haase, Kerstin, primary, Schäfer, Beat W., primary, Wachtel, Marco, primary, Kühl, Anja A., primary, Ortiz, Michael V., primary, Wengner, Antje M., primary, Scheer, Monika, primary, and Henssen, Anton G., primary

Published
2024
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21. Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors

Author

Timme, Natalie, Han, Youjia, Liu, Shuai, Yosief, Hailemichael O., García, Heathcliff Dorado, Bei, Yi, Klironomos, Filippos, MacArthur, Ian C., Szymansky, Annabell, von Stebut, Jennifer, Bardinet, Victor, Dohna, Constantin, Künkele, Annette, Rolff, Jana, Hundsdörfer, Patrick, Lissat, Andrej, Seifert, Georg, Eggert, Angelika, Schulte, Johannes H., Zhang, Wei, and Henssen, Anton G.

Published
2020
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22. Elimusertib has anti-tumor activity in preclinical patient-derived pediatric solid tumor models

Author

Pusch, Fabian F; https://orcid.org/0000-0002-7152-080X, Dorado Garcia, Heathcliff; https://orcid.org/0000-0002-2578-3350, Xu, Robin; https://orcid.org/0000-0002-5618-246X, Gürgen, Dennis; https://orcid.org/0000-0001-9241-6537, Bei, Yi; https://orcid.org/0000-0002-2104-8025, Brückner, Lotte; https://orcid.org/0000-0002-6155-2277, Röefzaad, Claudia; https://orcid.org/0000-0003-2299-6673, von Stebut, Jennifer; https://orcid.org/0000-0001-9811-445X, Bardinet, Victor; https://orcid.org/0000-0002-9583-7043, Chamorro Gonzalez, Rocío; https://orcid.org/0000-0002-5653-7259, Eggert, Angelika; https://orcid.org/0000-0003-3476-8184, Schulte, Johannes H; https://orcid.org/0000-0003-0671-1201, Hundsdörfer, Patrick; https://orcid.org/0009-0007-1158-5170, Seifert, Georg; https://orcid.org/0000-0002-7109-9277, Haase, Kerstin; https://orcid.org/0000-0002-0944-5618, Schäfer, Beat W; https://orcid.org/0000-0001-5988-2915, Wachtel, Marco; https://orcid.org/0000-0002-6077-3692, Kühl, Anja A; https://orcid.org/0000-0003-2293-5387, Ortiz, Michael V; https://orcid.org/0000-0001-9379-314X, Wengner, Antje M; https://orcid.org/0009-0009-5772-1945, Scheer, Monika; https://orcid.org/0000-0002-0665-6268, Henssen, Anton G; https://orcid.org/0000-0003-1534-778X, Pusch, Fabian F; https://orcid.org/0000-0002-7152-080X, Dorado Garcia, Heathcliff; https://orcid.org/0000-0002-2578-3350, Xu, Robin; https://orcid.org/0000-0002-5618-246X, Gürgen, Dennis; https://orcid.org/0000-0001-9241-6537, Bei, Yi; https://orcid.org/0000-0002-2104-8025, Brückner, Lotte; https://orcid.org/0000-0002-6155-2277, Röefzaad, Claudia; https://orcid.org/0000-0003-2299-6673, von Stebut, Jennifer; https://orcid.org/0000-0001-9811-445X, Bardinet, Victor; https://orcid.org/0000-0002-9583-7043, Chamorro Gonzalez, Rocío; https://orcid.org/0000-0002-5653-7259, Eggert, Angelika; https://orcid.org/0000-0003-3476-8184, Schulte, Johannes H; https://orcid.org/0000-0003-0671-1201, Hundsdörfer, Patrick; https://orcid.org/0009-0007-1158-5170, Seifert, Georg; https://orcid.org/0000-0002-7109-9277, Haase, Kerstin; https://orcid.org/0000-0002-0944-5618, Schäfer, Beat W; https://orcid.org/0000-0001-5988-2915, Wachtel, Marco; https://orcid.org/0000-0002-6077-3692, Kühl, Anja A; https://orcid.org/0000-0003-2293-5387, Ortiz, Michael V; https://orcid.org/0000-0001-9379-314X, Wengner, Antje M; https://orcid.org/0009-0009-5772-1945, Scheer, Monika; https://orcid.org/0000-0002-0665-6268, and Henssen, Anton G; https://orcid.org/0000-0003-1534-778X

Abstract

The small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its preclinical anti-tumor activity in pediatric malignancies, however, is largely unknown. We here assessed the preclinical activity of elimusertib in 38 cell lines and 32 patient-derived xenograft (PDX) models derived from common pediatric solid tumor entities. Detailed in vitro and in vivo molecular characterization of the treated models enabled the evaluation of response biomarkers. Pronounced objective response rates were observed for elimusertib monotherapy in PDX, when treated with a regimen currently used in clinical trials. Strikingly, elimusertib showed stronger anti-tumor effects than some standard of care chemotherapies, particularly in alveolar rhabdomysarcoma PDX. Thus, elimusertib has strong preclinical anti-tumor activity in pediatric solid tumor models, which may translate to clinically meaningful responses in patients.

Published
2024

24. Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

Author

Pusch, Fabian, primary, Dorado García, Heathcliff, additional, Xu, Robin, additional, Gürgen, Dennis, additional, Bei, Yi, additional, Brueckner, Lotte, additional, Röefzaad, Claudia, additional, von Stebut, Jennifer, additional, Bardinet, Victor, additional, Chamorro González, Rocío, additional, Eggert, Angelika, additional, Schulte, Johannes H., additional, Hundsdörfer, Patrick, additional, Seifert, Georg, additional, Haase, Kerstin, additional, Schaefer, Beat, additional, Wachtel, Marco, additional, Kühl, Anja A., additional, Ortiz, Michael V., additional, Wengner, Antje M., additional, Scheer, Monika, additional, and Henssen, Anton G., additional

Published
2022
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25. Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

Author

García, Heathcliff Dorado, primary, Bei, Yi, additional, von Stebut, Jennifer, additional, Ibáñez, Glorymar, additional, Imami, Koshi, additional, Gürgen, Dennis, additional, Rolff, Jana, additional, Helmsauer, Konstantin, additional, Timme, Natalie, additional, Bardinet, Victor, additional, González, Rocío Chamorro, additional, MacArthur, Ian C., additional, Pusch, Fabian, additional, Chen, Celine Y., additional, Schulz, Joachim, additional, Wengner, Antje M., additional, Furth, Christian, additional, Lala, Birgit, additional, Eggert, Angelika, additional, Seifert, Georg, additional, Hundsoerfer, Patrick, additional, Kirchner, Marieluise, additional, Mertins, Philipp, additional, Selbach, Matthias, additional, Lissat, Andrej, additional, Schulte, Johannes H., additional, Haase, Kerstin, additional, Scheer, Monika, additional, Ortiz, Michael V., additional, and Henssen, Anton G., additional

Published
2020
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26. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

Author

Henssen, Anton G., primary, Reed, Casie, additional, Jiang, Eileen, additional, Garcia, Heathcliff Dorado, additional, von Stebut, Jennifer, additional, MacArthur, Ian C., additional, Hundsdoerfer, Patrick, additional, Kim, Jun Hyun, additional, Stanchina, Elisa de, additional, Kuwahara, Yasumichi, additional, Hosoi, Hajime, additional, Ganem, Neil, additional, Cruz, Filemon Dela, additional, Kung, Andrew L., additional, Schulte, Johannes H., additional, Petrini, John H., additional, and Kentsis, Alex, additional

Published
2017
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27. Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models.

Author

Pusch FF, Dorado García H, Xu R, Gürgen D, Bei Y, Brückner L, Röefzaad C, von Stebut J, Bardinet V, Chamorro Gonzalez R, Eggert A, Schulte JH, Hundsdörfer P, Seifert G, Haase K, Schäfer BW, Wachtel M, Kühl AA, Ortiz MV, Wengner AM, Scheer M, and Henssen AG

Subjects
Child, Humans, Xenograft Model Antitumor Assays, Protein Kinase Inhibitors therapeutic use, Biomarkers, Cell Line, Tumor, Neoplasms drug therapy, Neoplasms pathology, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use
Abstract

The small-molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its preclinical antitumor activity in pediatric malignancies, however, is largely unknown. We here assessed the preclinical activity of elimusertib in 38 cell lines and 32 patient-derived xenograft (PDX) models derived from common pediatric solid tumor entities. Detailed in vitro and in vivo molecular characterization of the treated models enabled the evaluation of response biomarkers. Pronounced objective response rates were observed for elimusertib monotherapy in PDX, when treated with a regimen currently used in clinical trials. Strikingly, elimusertib showed stronger antitumor effects than some standard-of-care chemotherapies, particularly in alveolar rhabdomysarcoma PDX. Thus, elimusertib has strong preclinical antitumor activity in pediatric solid tumor models, which may translate to clinically meaningful responses in patients., (©2023 The Authors; Published by the American Association for Cancer Research.)

Published
2024
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