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2. Reply to Italiano et al

Author

Esposito, Douglas H., Rosenthal, Benjamin M., Slesak, Günther, Tappe, Dennis, Fayer, Ronald, Bottieau, Emmanuel, Brown, Clive, Grobusch, Martin P., Malvy, Denis, von Sonnenburg, Frank, Sotir, Mark J., Steiner, Florian, Zanger, Philipp, and Kozarsky, Phyllis E.

Published
2015

4. Acute Muscular Sarcocystosis: An International Investigation Among Ill Travelers Returning From Tioman Island, Malaysia, 2011-2012

Author

Tioman Island Sarcocystosis Investigation Teama, Esposito, Douglas H., Stich, August, Epelboin, Loïc, Malvy, Denis, Han, Pauline V., Bottieau, Emmanuel, da Silva, Alexandre, Zanger, Philipp, Slesak, Günther, van Genderen, Perry J. J., Rosenthal, Benjamin M., Cramer, Jakob P., Visser, Leo G., Muñoz, José, Drew, Clifton P., Goldsmith, Cynthia S., Steiner, Florian, Wagner, Noémie, Grobusch, Martin P., Plier, D. Adam, Tappe, Dennis, Sotir, Mark J., Brown, Clive, Brunette, Gary W., Fayer, Ronald, von Sonnenburg, Frank, Neumayr, Andreas, and Kozarsky, Phyllis E.

Published
2014
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6. Causes of non-malarial fever in Laos: a prospective study

Author

Mayxay, Mayfong, Castonguay-Vanier, Josée, Chansamouth, Vilada, Dubot-Pérès, Audrey, Paris, Daniel H, Phetsouvanh, Rattanaphone, Tangkhabuanbutra, Jarasporn, Douangdala, Phouvieng, Inthalath, Saythong, Souvannasing, Phoutthalavanh, Slesak, Günther, Tongyoo, Narongchai, Chanthongthip, Anisone, Panyanouvong, Phonepasith, Sibounheuang, Bountoy, Phommasone, Koukeo, Dohnt, Michael, Phonekeo, Darouny, Hongvanthong, Bouasy, Xayadeth, Sinakhone, Ketmayoon, Pakapak, Blacksell, Stuart D, Moore, Catrin E, Craig, Scott B, Burns, Mary-Anne, von Sonnenburg, Frank, Corwin, Andrew, de Lamballerie, Xavier, González, Iveth J, Christophel, Eva Maria, Cawthorne, Amy, Bell, David, and Newton, Paul N

Published
2013
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7. Local and international implications of schistosomiasis acquired in Corsica, France

Author

Gautret, Philippe, Mockenhaupt, Frank P., von Sonnenburg, Frank, Rothe, Camilla, Libman, Michael, Van De Winkel, Kristina, Bottieau, Emmanuel, Grobusch, Martin P., Hamer, Davidson H., Esposito, Douglas H., Parola, Philippe, and Schlagenhauf, Patricia

Subjects
Schistosomiasis -- Health aspects -- Risk factors -- Diagnosis -- Research, Disease transmission -- Research, Health
Abstract

In 2014, reports were received of several cases of Schistosoma haematobium trematode infection acquired in Corsica, a Mediterranean French island. The first patient was a child from Germany who had [...]

Published
2015
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9. Sex and Gender Differences in Travel-Associated Disease

Author

Schlagenhauf, Patricia, Chen, Lin H., Wilson, Mary E., Freedman, David O., Tcheng, David, Schwartz, Eli, Pandey, Prativa, Weber, Rainer, Nadal, David, Berger, Christoph, von Sonnenburg, Frank, Keystone, Jay, and Leder, Karin

Published
2010

10. Regional variation in travel-related illness acquired in Africa, March 1997-May 2011

Author

Mendelson, Marc, Han, Pauline V., Vincent, Peter, von Sonnenburg, Frank, Cramer, Jakob P., Loutan, Louis, Kain, Kevin C., Parola, Philippe, Hagmann, Stefan, Gkrania-Klotsas, Effrossyni, Sotir, Mark, and Schlagenhauf, Patricia

Subjects
Travel -- Health aspects -- Africa, Diseases -- Risk factors -- Demographic aspects -- Africa, Travelers -- Health aspects, Health
Abstract

Africa is a popular tourist destination and a focus for international aid work, research, and business travel. In 2011, compared with 2010, international arrivals on the African continent remained relatively [...]

Published
2014
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12. Travel-associated diseases, Indian Ocean islands, 1997-2010

Author

Savini, Helene, Gautret, Philippe, Gaudart, Jean, Field, Vanessa, Castelli, Francesco, Lopez-Velez, Rogelio, Lim, Poh Lian, Shaw, Marc, von Sonnenburg, Frank, Loutan, Louis, and Simon, Fabrice

Subjects
Infection -- Health aspects, Malaria -- Health aspects, Health
Abstract

The outbreak of chikungunya fever in Indian Ocean islands (IOI) provides new insights on emerging infections in this geographic region (1). We present data collected over 14 years from travelers [...]

Published
2013
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13. Travel-associated illness trends and clusters, 2000-2010

Author

Leder, Karin, Torresi, Joseph, Brownstein, John S., Wilson, Mary E., Keystone, Jay S., Barnett, Elizabeth, Schwartz, Eli, Schlagenhauf, Patricia, Wilder-Smith, Annelies, Castelli, Francesco, von Sonnenburg, Frank, Freedman, David O., and Cheng, Allen C.

Subjects
Communicable diseases -- Risk factors, Travel industry -- Health aspects, Travelers -- Health aspects, Health
Abstract

International travel is markedly increasing. In 2010, an estimated 940 million tourists arrived at international destinations, more than twice the 435 million in 1990 (1). Trips to developing regions have [...]

Published
2013
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16. Travel-Related Infection in European Travelers, EuroTravNet 2011

Author

Warne, Ben, Weld, Leisa H., Cramer, Jakob P., Field, Vanessa K., Grobusch, Martin P., Caumes, Eric, Jensenius, Mogens, Gautret, Philippe, Schlagenhauf, Patricia, Castelli, Francesco, Lalloo, David G., Ursing, Johan, Chappuis, François, von Sonnenburg, Frank, López-Vélez, Rogelio, Rapp, Christophe, Smith, Kitty C., Parola, Philippe, and Gkrania-Klotsas, Effrossyni

Published
2014
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18. Multicenter geosentinel analysis of rickettsial diseases in international travelers, 1996-2008

Author

Jensenius, Mogens, Davis, Xiaohong, von Sonnenburg, Frank, Schwartz, Eli, Keystone, Jay S., Leder, Karin, Lopez-Velez, Rogelio, Caumes, Eric, Cramer, Jakob P., Chen, Lin, and Parola, Philippe

Subjects
Travelers -- Analysis, Travel industry -- Analysis, Medical research -- Analysis, Medicine, Experimental -- Analysis
Abstract

Rickettsial diseases are acute and potentially severe zoonotic infections caused by obligate intracellular, gram-negative bacteria belonging to the order Rickettsiales. The taxonomy of Rickettsiales is complex and continues to be [...]

Published
2009

19. Multicenter EuroTravNet/GeoSentinel study of travel-related infectious diseases in Europe

Author

Gautret, Philippe, Schlagenhauf, Patricia, Gaudart, Jean, Castelli, Francesco, Brouqui, Philippe, von Sonnenburg, Frank, Loutan, Louis, and Parola, Philippe

Subjects
Malaria -- Care and treatment, Travelers, Medical research, Medicine, Experimental, Travel
Abstract

In recent years, growth in international travel has been [approximately equal to] 6% per year, and similar trends are expected in the future (1). This growth has been strongly driven [...]

Published
2009
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20. Seasonality, annual trends, and characteristics of dengue among III returned travelers, 1997-2006

Author

Schwartz, Eli, Weld, Leisa H., Wilder-Smith, Annelies, von Sonnenburg, Frank, Keystone, Jay S., Kain, Kevin C., Torresi, Joseph, and Freedman, David O.

Subjects
Company distribution practices, United States. Centers for Disease Control and Prevention -- Reports, Travelers -- Health aspects, Dengue -- Risk factors, Dengue -- Distribution, Dengue -- Prevention, Dengue -- Analysis, Disease transmission -- Health aspects, Disease transmission -- Analysis
Abstract

We examined seasonality and annual trends for dengue cases among 522 returned travelers reported to the international GeoSentinel Surveillance Network. Dengue cases showed region-specific peaks for Southeast Asia (June, September), [...]

Published
2008

21. Travel-related infections presenting in Europe: a 20-year analysis of EuroTravNet surveillance data

Author

Grobusch, Martin P., Weld, Leisa, Goorhuis, Abraham, Hamer, Davidson H., Schunk, Mirjam, Jordan, Sabine, Mockenhaupt, Frank P., Chappuis, François, Asgeirsson, Hilmir, Caumes, Eric, Jensenius, Mogens, van Genderen, Perry J.J., Castelli, Francesco, López-Velez, Rogelio, Field, Vanessa, Bottieau, Emmanuel, Molina, Israel, Rapp, Christophe, Ménendez, Marta Díaz, Gkrania-Klotsas, Effrossyni, Larsen, Carsten S., Malvy, Denis, Lalloo, David, Gobbi, Federico, Florescu, Simin A., Gautret, Philippe, Schlagenhauf, Patricia, Stijnis, Kees, van Vugt, Michèle, Rothe, Camilla, von Sonnenburg, Frank, Vinnemeier, Christof, Ramharter, Michael, Equihua Martinez, Gabriela, Gertler, Maximilian, Eperon, Gilles, Ursing, Johan, Glans, Hedvig, Hægeland, Arnhild, Joof, Mona, Stuij, Corine, Odolini, Silvia, Tomasoni, Lina, Chamorro, Sandra, Lankester, Ted, Salvador, Fernando, Serre-Delcor, Nuria, Ficko, Cécile, Trigo, Elena, Warne, Benjamin, Jespersen, Sanne, Weijse, Christian, Duvignaud, Alexandre, Pistone, Thierry, Beeching, Nicholas, Beadsworth, Mike, Rodari, Paola, Moro, Lucia, Popescu, Corneliu P., Zaharia, Mihaela F., Javelle, Emilie, Parola, Philippe, Weber, Rainer, and Schmid-Stoll, Sabine

Subjects
wa_108
Abstract

Background\ud Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance of travel-associated illness important.\ud \ud Methods\ud We evaluated travel-related illness encountered at EuroTravNet clinics, the European surveillance sub-network of GeoSentinel, between March 1, 1998 and March 31, 2018.\ud \ud Findings\ud 103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, and 2,880 (2.8%) during and after travel. Despite increasing numbers of patient encounters over 20 years, the regions of exposure by year of clinic visits have remained stable. In 5-year increments, greater proportions of patients were migrants or visiting friends and relatives (VFR); business travel-associated illness remained stable; tourism-related illness decreased. Falciparum malaria was amongst the most-frequently diagnosed illnesses with 5,254 cases (5.1% of all patients) and the most-frequent cause of death (risk ratio versus all other illnesses 2.5:1). Animal exposures requiring rabies post-exposure prophylaxis increased from 0.7% (1998-2002) to 3.6% (2013-2018). The proportion of patients with seasonal influenza increased from zero in 1998-2002 to 0.9% in 2013-2018. There were 44 cases of viral haemorrhagic fever, most during the past five years. Arboviral infection numbers increased significantly as did the range of presenting arboviral diseases, Dengue and chikungunya diagnoses increased by 2.6% and 1%, respectively.\ud \ud Interpretation\ud Travel medicine must adapt to serve the changing profile of travellers, with an increase in migrants and persons visiting relatives and friends and the strong emergence of vector-borne diseases, with potential for further local transmission in Europe.\ud \ud Funding\ud This project was supported by a cooperative agreement (U50CK00189) between the Centers for Disease Control and Prevention to the International Society of Travel Medicine (ISTM) and funding from the ISTM and the Public Health Agency of Canada.

Published
2020

24. Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial

Author

Aldrich, Cassandra, primary, Leroux–Roels, Isabel, additional, Huang, Katell Bidet, additional, Bica, Mihai Alexandru, additional, Loeliger, Edde, additional, Schoenborn-Kellenberger, Oliver, additional, Walz, Lisa, additional, Leroux-Roels, Geert, additional, von Sonnenburg, Frank, additional, and Oostvogels, Lidia, additional

Published
2021
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25. Hepatitis A and B booster recommendations: implications for travelers

Author

Zuckerman, Jane N., Connor, Bradley A., and von Sonnenburg, Frank

Subjects
Hepatitis A -- Risk factors, Hepatitis A -- Drug therapy, Hepatitis B -- Risk factors, Hepatitis B -- Drug therapy, Hepatitis A vaccine -- Dosage and administration, Hepatitis B vaccine -- Dosage and administration, Health, Health care industry
Published
2005

26. GeoSentinel Surveillance of Illness in Returned Travelers, 2007–2011

Author

Leder, Karin, Torresi, Joseph, Libman, Michael D., Cramer, Jakob P., Castelli, Francesco, Schlagenhauf, Patricia, Wilder-Smith, Annelies, Wilson, Mary E., Keystone, Jay S., Schwartz, Eli, Barnett, Elizabeth D., von Sonnenburg, Frank, Brownstein, John S., Cheng, Allen C., Sotir, Mark J., Esposito, Douglas H., and Freedman, David O.

Published
2013

33. Chikungunya resurgence in the Maldives and risk for importation via tourists to Europe in 2019–2020: A GeoSentinel case series

Author

Dudouet, Pierre, primary, Gautret, Philippe, additional, Larsen, Carsten Schade, additional, Díaz-Menéndez, Marta, additional, Trigo, Elena, additional, von Sonnenburg, Frank, additional, Gobbi, Federico, additional, Grobusch, Martin P., additional, Malvy, Denis, additional, Field, Vanessa, additional, Asgeirsson, Hilmir, additional, Souto, Inés Oliveira, additional, Hamer, Davidson H., additional, Parola, Philippe, additional, and Javelle, Emilie, additional

Published
2020
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40. Cutaneous and mucocutaneous leishmaniasis in travellers and migrants: a 20-year GeoSentinel Surveillance Network analysis

Author

Boggild, Andrea, Caumes, Eric, Grobusch, Martin, Schwartz, Eli, Hynes, Noreen, Libman, Michael, Connor, Bradley, Chakrabarti, Sumontra, Parola, Philippe, Keystone, Jay, Nash, Theodore, Showler, Adrienne, Schunk, Mirjam, Asgeirsson, Hilmir, Hamer, Davidson, Kain, Kevin, Von Sonnenburg, Frank, Rothe, Camilla, Jordan, Sabine, Vinnemeier, Christof, Yansouni, Cedric, McCarthy, Anne, Jensenius, Mogens, Goorhuis, Abraham, Coyle, Christina, Mockenhaupt, Frank, Harms-Zwingengerger, Gundel, Leung, Daniel, Benson, Scott, Gautret, Philippe, Javelle, Emilie, Chappuis, François, Rapp, Christophe, Ficko, Cécile, Van Genderen, Perry, Glans, Hedvig, Beadsworth, Michael, Beeching, Nicholas, Castelli, Francesco, Matteelli, Alberto, Plewes, Katherine, Mirzanejad, Yazdan, López-Vélez, Rogelio, Chamorro, Sandra, Waggoner, Jesse, Wu, Henry, Leder, Karin, Torresi, Joseph, Bottieau, Emmanuel, Huits, Ralph, Chen, Lin, Bourque, Daniel, Alpern, Jonathan, Stauffer, William, Cahill, John, Wyler, Ben, Haulman, Jean, Terry, Anne, Licitra, Carmelo, Taylor, Ashley, Perret Perez, Cecilia, Weitzel, Thomas, Gkrania-Klotsas, Effrossyni, Warne, Ben, Schlagenhauf, Patricia, Weber, Rainer, Schade Larsen, Carsten, Wejse, Christian, Barnett, Elizabeth, Hochberg, Natasha, Barkati, Sapha, Vincelette, Jean, Molina, Israel, Malvy, Denis, Duvignaud, Alexandre, Mendelson, Marc, Parker, Salim, Johnston, Victoria, Field, Vanessa, Kuhn, Susan, Piyaphanee, Watcharapong, Silachamroon, Udomsak, Diaz-Menendez, Marta, Kelly, Paul, Blumberg, Lucille, de Frey, Albie, Pandey, Prativa, Amatya, Bhawana, Mavunda, Kunjana, Saio, Mauro, CHU Pitié-Salpêtrière [APHP], Department of Infectious Diseases [Amsterdam, Netherlands] (Academic Medical Center), University of Amsterdam [Amsterdam] (UvA)-Center for Tropical and Travel Medicine [Amsterdam, Netherlands], Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Centre for Tropical Diseases [Montréal] (TDC), McGill University, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Department of Tropical Medicine and Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, Bernhard-Nocht-Institute for Tropical Medicine, Tropical Disease Unit [Toronto, Canada], University of Toronto, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Geneva University Hospitals - HUG [Switzerland], Hôpital d'Instruction des Armées Begin, Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Addenbrooke's Hospital, Cambridge University NHS Trust, Service de médecine interne et maladies infectieuses, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Université Paris Descartes - Paris 5 (UPD5), University of Cape Town, National Institute for Communicable Diseases (NICD), CIWEC Clinic Travel Medicine Center, Katmandu, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] (BNITM), National Institute for Communicable Diseases [Johannesburg] (NICD), Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
Leishmaniasis, Mucocutaneous, Male, Immigration, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Epidemiology, Species identification, 030212 general & internal medicine, Political instability, Child, ComputingMilieux_MISCELLANEOUS, media_common, Aged, 80 and over, Transients and Migrants, Cutaneous leishmaniasis, Geosentinel, Mucosal leishmaniasis, Skin lesions after travel, Tegumentary leishmaniasis, Vector-borne disease, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, General Medicine, Middle Aged, 3. Good health, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Original Article, Travel-Related Illness, Adult, Costa Rica, Bolivia, Canada, medicine.medical_specialty, Adolescent, media_common.quotation_subject, 030231 tropical medicine, Young Adult, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine, Leishmania (Viannia) braziliensis, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Aged, Syria, business.industry, Afghanistan, Infant, Leishmaniasis, Mucocutaneous leishmaniasis, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, Demography
Abstract

Background Cutaneous leishmaniasis (CL) may be emerging among international travellers and migrants. Limited data exist on mucocutaneous leishmaniasis (MCL) in travellers. We describe the epidemiology of travel-associated CL and MCL among international travellers and immigrants over a 20-year period through descriptive analysis of GeoSentinel data. Methods Demographic and travel-related data on returned international travellers diagnosed with CL or MCL at a GeoSentinel Surveillance Network site between 1 September 1997 and 31 August 2017 were analysed. Results A total of 955 returned travellers or migrants were diagnosed with travel-acquired CL (n = 916) or MCL during the study period, of whom 10% (n = 97) were migrants. For the 858 non-migrant travellers, common source countries were Bolivia (n = 156, 18.2%) and Costa Rica (n = 97, 11.3%), while for migrants, they were Syria (n = 34, 35%) and Afghanistan (n = 22, 22.7%). A total of 99 travellers (10%) acquired their disease on trips of ≤ 2 weeks. Of 274 cases for which species identification was available, Leishmania Viannia braziliensis was the most well-represented strain (n = 117, 42.7%), followed by L. major (n = 40, 14.6%) and L. V. panamensis (n = 38, 13.9%). Forty cases of MCL occurred, most commonly in tourists (n = 29, 72.5%) and from Bolivia (n = 18, 45%). A total of 10% of MCL cases were acquired in the Old World. Conclusions Among GeoSentinel reporting sites, CL is predominantly a disease of tourists travelling mostly to countries in Central and South America such as Bolivia where risk of acquiring L. V. braziliensis and subsequent MCL is high. The finding that some travellers acquired leishmaniasis on trips of short duration challenges the common notion that CL is a disease of prolonged travel. Migrants from areas of conflict and political instability, such as Afghanistan and Syria, were well represented, suggesting that as mass migration of refugees continues, CL will be increasingly encountered in intake countries.

Published
2019
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41. The rise in travel-associated measles infections-GeoSentinel, 2015-2019

Author

Angelo, Kristina, Libman, Michael, Gautret, Philippe, Barnett, Elizabeth, Grobusch, Martin, Hagmann, Stefan, Gobbi, Federico, Schwartz, Eli, van Genderen, Perry, Asgeirsson, Hilmer, Hamer, Davidson, Larsen, Carsten Schade, Wejse, Christian, Goorhuis, Bram, Piyaphanee, Watcharapong, Silachamroon, Udomsak, Kuhn, Susan, Perez, Cecilia Perret, Weitzel, Thomas, Mendelson, Marc, Parker, Salim, Piper-Jenks, Nancy, Kerr, Christine, Lachish, Tamar, Pandey, Prativa, Murphy, Holly, Menéndez, Marta, Esteban, Elena, Leder, Karin, Torresi, Joe, Mavunda, Kunjana, Rothe, Camilla, von Sonnenburg, Frank, Javelle, Emilie, Ward, Brian, Jensenius, Mogens, Caumes, Eric, Lim, Poh Lian, Glans, Hedvig, Yoshimura, Yukihiro, Tachikawa, Natsuo, Division of Global Migration and Quarantine [Atlanta, GA, USA], Centers for Disease Control and Prevention (CDC), Centre for Tropical Diseases [Montréal] (TDC), McGill University = Université McGill [Montréal, Canada], Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Department of Infectious Diseases [Amsterdam, Netherlands] (Academic Medical Center), University of Amsterdam [Amsterdam] (UvA)-Center for Tropical and Travel Medicine [Amsterdam, Netherlands], Cohen Children’s Medical Center, Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Cape Town, Département de radiothérapie, CRLCC Val d'Aurelle - Paul Lamarque, CIWEC Clinic Travel Medicine Center, Katmandu, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Laboratoire d'Economie de Dauphine (LEDa), Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Département des Maladies infectieuses [Marseille], Hôpital d'instruction des armées Laveran [Marseille], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), McGill University, Institut Hospitalier Universitaire Méditerranée Infection (IHU AMU), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses [CHU Pitié-Salêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL-Centre National de la Recherche Scientifique (CNRS), Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, and Medical Microbiology & Infectious Diseases

Subjects
Adult, Male, Vaccination Coverage, Adolescent, Measles Vaccine, 030231 tropical medicine, MEDLINE, Global Health, Measles, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Environmental health, Global health, Humans, Medicine, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030212 general & internal medicine, Young adult, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, Infant, General Medicine, Middle Aged, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Hospitalization, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Measles vaccine, Travel-Related Illness, business
Abstract

The global threat of measles in recent years affects international travelers, and is acquired in both endemic and outbreak settings. The number of measles cases reported to GeoSentinel has risen each year since 2015 and demonstrates a high median age, short travel duration, and low measles vaccination coverage.

Published
2019
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48. Travel and migration associated infectious diseases morbidity in Europe, 2008

Author

Lopez-Velez Rogelio, Weld Leisa, Gkrania-Klotsas Effrossyni, Castelli Francesco, Jensenius Mogens, Caumes Eric, Burchard Gerd-Dieter, Schlagenhauf Patricia, Gautret Philippe, Field Vanessa, de Vries Peter, von Sonnenburg Frank, Loutan Louis, and Parola Philippe

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Europeans represent the majority of international travellers and clinicians encountering returned patients have an essential role in recognizing, and communicating travel-associated public health risks. Methods To investigate the morbidity of travel associated infectious diseases in European travellers, we analysed diagnoses with demographic, clinical and travel-related predictors of disease, in 6957 ill returned travellers who presented in 2008 to EuroTravNet centres with a presumed travel associated condition. Results Gastro-intestinal (GI) diseases accounted for 33% of illnesses, followed by febrile systemic illnesses (20%), dermatological conditions (12%) and respiratory illnesses (8%). There were 3 deaths recorded; a sepsis caused by Escherichia coli pyelonephritis, a dengue shock syndrome and a Plasmodium falciparum malaria. GI conditions included bacterial acute diarrhea (6.9%), as well as giardiasis and amebasis (2.3%). Among febrile systemic illnesses with identified pathogens, malaria (5.4%) accounted for most cases followed by dengue (1.9%) and others including chikungunya, rickettsial diseases, leptospirosis, brucellosis, Epstein Barr virus infections, tick-borne encephalitis (TBE) and viral hepatitis. Dermatological conditions were dominated by bacterial infections, arthropod bites, cutaneous larva migrans and animal bites requiring rabies post-exposure prophylaxis and also leishmaniasis, myasis, tungiasis and one case of leprosy. Respiratory illness included 112 cases of tuberculosis including cases of multi-drug resistant or extensively drug resistant tuberculosis, 104 cases of influenza like illness, and 5 cases of Legionnaires disease. Sexually transmitted infections (STI) accounted for 0.6% of total diagnoses and included HIV infection and syphilis. A total of 165 cases of potentially vaccine preventable diseases were reported. Purpose of travel and destination specific risk factors was identified for several diagnoses such as Chagas disease in immigrant travellers from South America and P. falciparum malaria in immigrants from sub-Saharan Africa. Travel within Europe was also associated with health risks with distinctive profiles for Eastern and Western Europe. Conclusions In 2008, a broad spectrum of travel associated diseases were diagnosed at EuroTravNet core sites. Diagnoses varied according to regions visited by ill travellers. The spectrum of travel associated morbidity also shows that there is a need to dispel the misconception that travel, close to home, in Europe, is without significant health risk.

Published
2010
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49. Acute Muscular Sarcocystosis: An International Investigation Among Ill Travelers Returning From Tioman Island, Malaysia, 2011-2012

Author

Esposito, Douglas H., Stich, August, Epelboin, Loïc, Malvy, Denis, Han, Pauline V., Bottieau, Emmanuel, da Silva, Alexandre, Zanger, Philipp, Slesak, Günther, van Genderen, Perry J. J., Rosenthal, Benjamin M., Cramer, Jakob P., Visser, Leo G., Muñoz, José, Drew, Clifton P., Goldsmith, Cynthia S., Steiner, Florian, Wagner, Noémie, Grobusch, Martin P., Plier, D. Adam, Tappe, Dennis, Sotir, Mark J., Brown, Clive, Brunette, Gary W., Fayer, Ronald, von Sonnenburg, Frank, Neumayr, Andreas, Kozarsky, Phyllis E., Van Den Enden, Erwin, Van Esbroeck, Marjan, Ghesquiere, Wayne, Nguyen, Duc, Receveur, Marie-Catherine, Peyron, François, Parola, Philippe, Savini, Hélène, Caumes, Eric, Perignon, Alice, Develoux, Michel, Rapp, Christophe, Keller, Christian A., Haditsch, Martin, Güthoff, Wolfgang, Liebold, Ines, Schäfer, Johannes, Gobbi, Federico, Kortmann, Willemijn, van Twillert, Gitte, Goorhuis, Abraham, Harris, Vanessa, van Vugt, Michèle, Stijnis, Kees, Aronica, Eleonora, van Lieshout, Lisette, Roestenberg, Meta, van Wout, Jan, Barkham, Timothy, Lim, Poh Lian, Chian, Lee Kong, Hatz, Christoph, Brugger, Silvio D., Furrer, Hansjakob, Chappuis, François, Michel, Yann, Choochumporn, Sanya, Narkwiboonwong, Than, Dryden, Matthew S., Benedict, Theresa, Handali, Sukwan, Wilkins, Patricia P., Shieh, Wun-Ju, Zaki, Sherif, Kogelman, Laura, and Hatch, Steven

Subjects
musculoskeletal diseases, parasitic diseases, virus diseases, human activities, geographic locations
Abstract

A large outbreak of acute muscular sarcocystosis (AMS) among international tourists who visited Tioman Island, Malaysia, is described. Clinicians evaluating travelers returning ill from Malaysia with myalgia, with or without fever, should consider AMS in their differential diagnosis

Published
2017

50. A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients

Author

Rello, Jordi, Krenn, Claus-Georg, Locker, Gottfried, Pilger, Ernst, Madl, Christian, Balica, Laura, Dugernier, Thierry, Laterre, Pierre-Francois, Spapen, Herbert, Depuydt, Pieter, Vincent, Jean-Louis, Bogár, Lajos, Szabó, Zsuzsanna, Völgyes, Barbara, Máñez, Rafael, Çakar, Nahit, Ramazanoglu, Atilla, Topeli, Arzu, Mastruzzo, Maria A., Jasovich, Abel, Remolif, Christian G., del Carmen Soria, Liliana, Andresen Hernandez, Max A., Ruiz Balart, Carolina, Krémer, Ildikó, Molnár, Zsolt, von Sonnenburg, Frank, Lyons, Arthur, Joannidis, Michael, Burgmann, Heinz, Welte, Tobias, Klingler, Anton, Hochreiter, Romana, Westritschnig, Kerstin, Universitat Autònoma de Barcelona, Supporting clinical sciences, Internal Medicine Specializations, İç Hastalıkları, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
0301 basic medicine, Male, Soins intensifs réanimation, Letter, medicine.medical_treatment, Vacunes, Critical Care and Intensive Care Medicine, Placebos, Bacterial infections, Immunocompromised host, Vaccines, Immunogenicity, Vaccination, Bacterial Infections, Middle Aged, Intensive Care Units, Tolerability, Pseudomonas aeruginosa, Female, Adjuvant, Adult, medicine.medical_specialty, Pseudomonas Vaccines, 030106 microbiology, Bacterial diseases, Placebo, 03 medical and health sciences, Double-Blind Method, Internal medicine, Pseudomonas, Sepsis, medicine, Humans, Pseudomonas Infections, Seroconversion, Mortality, Adverse effect, Aged, Malalties bacterianes, business.industry, Immunity, medicine.disease, vaccination, Respiration, Artificial, immunity, 030104 developmental biology, Bacteremia, Immunology, business
Abstract

Background: Currently, no vaccine against Pseudomonas is available. IC43 is a new, recombinant, protein (OprF/I)-based vaccine against the opportunistic pathogen, Pseudomonas aeruginosa, a major cause of serious hospital-acquired infections. IC43 has proven immunogenicity and tolerability in healthy volunteers, patients with burns, and patients with chronic lung diseases. In order to assess the immunogenicity and safety of IC43 in patients who are most at risk of acquiring Pseudomonas infections, it was evaluated in mechanically ventilated ICU patients. Methods: We conducted a randomized, placebo-controlled, partially blinded study in mechanically ventilated ICU patients. The immunogenicity of IC43 at day 14 was determined as the primary endpoint, and safety, efficacy against P. aeruginosa infections, and all-cause mortality were evaluated as secondary endpoints. Vaccinations (100 μg or 200 μg IC43 with adjuvant, or 100 μg IC43 without adjuvant, or placebo) were given twice in a 7-day interval and patients were followed up for 90 days. Results: Higher OprF/I IgG antibody titers were seen at day 14 for all IC43 groups versus placebo (P < 0.0001). Seroconversion (≥4-fold increase in OprF/I IgG titer from days 0 to 14) was highest with 100 μg IC43 without adjuvant (80.6%). There were no significant differences in P. aeruginosa infection rates, with a low rate of invasive infections (pneumonia or bacteremia) in the IC43 groups (11.2-14.0%). Serious adverse events (SAEs) considered possibly related to therapy were reported by 2 patients (1.9%) in the group of 100 μg IC43 with adjuvant. Both SAEs resolved and no deaths were related to study treatment. Local tolerability symptoms were mild and rare (, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017
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