1. Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative
- Author
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Foreman, SC, Gersing, AS, von Schacky, CE, Joseph, GB, Neumann, J, Lane, NE, McCulloch, CE, Nevitt, MC, and Link, TM
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Arthritis ,Clinical Research ,Prevention ,Musculoskeletal ,Aged ,Cartilage ,Articular ,Case-Control Studies ,Chondrocalcinosis ,Disease Progression ,Female ,Humans ,Knee Joint ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Menisci ,Tibial ,Middle Aged ,Osteoarthritis ,Knee ,Patella ,Osteoarthritis ,MRI ,Knee ,Cartilage ,Biomedical Engineering ,Human Movement and Sports Sciences ,Arthritis & Rheumatology ,Clinical sciences ,Sports science and exercise - Abstract
ObjectiveTo determine if presence of calcium-containing crystals (CaC) is associated with increased knee joint degeneration over 4 years and assess if total number of CaCs deposited is a useful measure of disease burden.DesignSeventy subjects with CaCs in right knees at baseline were selected from the Osteoarthritis Initiative and matched to 70 subjects without evidence of CaCs. T1-weighted gradient-echo sequences were used to confirm presence of CaCs and count the numbers of distinct circumscribed CaCs. Morphological abnormalities were assessed at baseline and 4-year follow-up using the modified semi-quantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS). Linear regression models were used to analyze the associations between presence of CaCs at baseline and changes in WORMS and to analyze the associations between numbers of circumscribed CaCs at baseline and changes in WORMS.ResultsPresence of CaCs was associated with increased cartilage degeneration in the patella (coefficient: 0.33; 95% confidence interval (CI): 0.04-0.63), the medial femur (coefficient: 0.51; 95% CI: 0.18-0.83), the lateral tibia (coefficient: 0.36; 95% CI: 0.01-0.71) as well as the medial and lateral meniscus (coefficient: 0.38; 95% CI: 0.00-0.75 and coefficient: 0.72; 95% CI: 0.12-1.32). Knees with higher numbers of CaCs had increased cartilage degeneration in the patella and medial femur (coefficient: 0.09; 95% CI: 0.05-0.14; P
- Published
- 2020