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5. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J. R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024
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8. Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure

Author

Fan, Zheng, Karakone, Mara, Nagarajan, Shunmugam, Nagy, Nadine, Mildenberger, Wiebke, Petrova, Ekaterina, Hinte, Laura Catharina, Bijnen, Mitchell, Häne, Philipp, Nelius, Eric, Chen, Jing, Ferapontova, Irina, von Meyenn, Ferdinand, Trepiccione, Francesco, Berber, Mesut, Ribas, David Penton, Eichmann, Anne, Zennaro, Maria-Christina, Takeda, Norihiko, Fischer, Jens W., Spyroglou, Ariadni, Reincke, Martin, Beuschlein, Felix, Loffing, Johannes, Greter, Melanie, and Stockmann, Christian

Published
2024
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10. Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Author

Yeh, Yu-Te, Sona, Chandan, Yan, Xin, Li, Yunxiao, Pathak, Adrija, McDermott, Mark I., Xie, Zhigang, Liu, Liangwen, Arunagiri, Anoop, Wang, Yuting, Cazenave-Gassiot, Amaury, Ghosh, Adhideb, von Meyenn, Ferdinand, Kumarasamy, Sivarajan, Najjar, Sonia M., Jia, Shiqi, Wenk, Markus R., Traynor-Kaplan, Alexis, Arvan, Peter, Barg, Sebastian, Bankaitis, Vytas A., and Poy, Matthew N.

Published
2023
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15. H3K18 lactylation marks tissue-specific active enhancers

Author

Galle, Eva, Wong, Chee-Wai, Ghosh, Adhideb, Desgeorges, Thibaut, Melrose, Kate, Hinte, Laura C., Castellano-Castillo, Daniel, Engl, Magdalena, de Sousa, Joao Agostinho, Ruiz-Ojeda, Francisco Javier, De Bock, Katrien, Ruiz, Jonatan R., and von Meyenn, Ferdinand

Published
2022
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16. A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

Author

Li, Meng Amy, Amaral, Paulo P, Cheung, Priscilla, Bergmann, Jan H, Kinoshita, Masaki, Kalkan, Tüzer, Ralser, Meryem, Robson, Sam, von Meyenn, Ferdinand, Paramor, Maike, Yang, Fengtang, Chen, Caifu, Nichols, Jennifer, Spector, David L, Kouzarides, Tony, He, Lin, and Smith, Austin

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Health Sciences, Stem Cell Research, Human Genome, Stem Cell Research - Embryonic - Non-Human, Genetics, Generic health relevance, Animals, Cell Differentiation, DNA (Cytosine-5-)-Methyltransferases, DNA Methylation, DNA Methyltransferase 3A, Gene Deletion, Gene Expression Regulation, Mice, MicroRNAs, Mouse Embryonic Stem Cells, RNA, Long Noncoding, RNA-Binding Proteins, DNA Methyltransferase 3B, Lin28a/Mirlet7, de novo DNA methylation, developmental biology, long non-coding RNA, mouse, pluripotency, stem cell transition, stem cells, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (Eprn), that modulates the dynamics of exit from naïve pluripotency. Eprn deletion delays the extinction of ESC identity, an effect associated with perduring Nanog expression. In the absence of Eprn, Lin28a expression is reduced which results in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a/b is delayed. Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a. The connection from lncRNA to miRNA and DNA methylation facilitates the acute extinction of naïve pluripotency, a pre-requisite for rapid progression from preimplantation epiblast to gastrulation in rodents. Eprn illustrates how lncRNAs may introduce species-specific network modulations.

Published
2017

17. Dnmt1 has de novo activity targeted to transposable elements

Author

Haggerty, Chuck, Kretzmer, Helene, Riemenschneider, Christina, Kumar, Abhishek Sampath, Mattei, Alexandra L., Bailly, Nina, Gottfreund, Judith, Giesselmann, Pay, Weigert, Raha, Brändl, Björn, Giehr, Pascal, Buschow, René, Galonska, Christina, von Meyenn, Ferdinand, Pappalardi, Melissa B., McCabe, Michael T., Wittler, Lars, Giesecke-Thiel, Claudia, Mielke, Thorsten, Meierhofer, David, Timmermann, Bernd, Müller, Franz-Josef, Walter, Jörn, and Meissner, Alexander

Published
2021
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19. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J.R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, Prokesch, Andreas, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J.R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024

21. Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria

Author

Denley, Matthew Christopher Simon, primary, Straub, Monique S, additional, Marcionelli, Giulio, additional, Güra, Miriam A, additional, Penton Ribas, David, additional, Delvendahl, Igor, additional, Poms, Martin, additional, Vekeriotaite, Beata, additional, Conte, Federica, additional, von Meyenn, Ferdinand, additional, Froese, D Sean, additional, and Baumgartner, Matthias R, additional

Published
2024
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25. Epigenetic dynamics during capacitation of naïve human pluripotent stem cells

Author

Agostinho de Sousa, João, primary, Wong, Chee-Wai, additional, Dunkel, Ilona, additional, Owens, Thomas, additional, Voigt, Philipp, additional, Hodgson, Adam, additional, Baker, Duncan, additional, Schulz, Edda G., additional, Reik, Wolf, additional, Smith, Austin, additional, Rostovskaya, Maria, additional, and von Meyenn, Ferdinand, additional

Published
2023
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30. Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author

Sun, Wenfei, Dong, Hua, Becker, Anton S., Dapito, Dianne H., Modica, Salvatore, Grandl, Gerald, Opitz, Lennart, Efthymiou, Vissarion, Straub, Leon G., Sarker, Gitalee, Balaz, Miroslav, Balazova, Lucia, Perdikari, Aliki, Kiehlmann, Elke, Bacanovic, Sara, Zellweger, Caroline, Peleg-Raibstein, Daria, Pelczar, Pawel, Reik, Wolf, Burger, Irene A., von Meyenn, Ferdinand, and Wolfrum, Christian

Published
2018
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34. Single cell DNA methylation ageing in mouse blood

Author

Bonder, Marc Jan, primary, Clark, Stephen, additional, Krueger, Felix, additional, Luo, Siyuan, additional, Agostinho de Sousa, Joao, additional, Hashtroud, Aida M, additional, Stubbs, Thomas M, additional, Stark, Anne-Katrien, additional, Rulands, Steffen, additional, Stegle, Oliver, additional, Reik, Wolf, additional, and von Meyenn, Ferdinand, additional

Published
2023
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38. Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Author

Yeh, Yu-Te, primary, Sona, Chandan, additional, Yan, Xin, additional, Pathak, Adrija, additional, McDermott, Mark I., additional, Xie, Zhigang, additional, Liu, Liangwen, additional, Arunagiri, Anoop, additional, Wang, Yuting, additional, Cazenave-Gassiot, Amaury, additional, Ghosh, Adhideb, additional, von Meyenn, Ferdinand, additional, Kumarasamy, Sivarajan, additional, Najjar, Sonia M., additional, Jia, Shiqi, additional, Wenk, Markus R., additional, Traynor-Kaplan, Alexis, additional, Arvan, Peter, additional, Barg, Sebastian, additional, Bankaitis, Vytas A., additional, and Poy, Matthew N., additional

Published
2022
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40. Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells

Author

Kim, Inseon; https://orcid.org/0000-0003-1483-3890, Ghosh, Adhideb; https://orcid.org/0000-0002-5160-4571, Bundschuh, Nicola, Hinte, Laura; https://orcid.org/0000-0002-4226-0009, Petrosyan, Eduard, von Meyenn, Ferdinand; https://orcid.org/0000-0001-9920-3075, Bar-Nur, Ori; https://orcid.org/0000-0002-6466-3124, Kim, Inseon; https://orcid.org/0000-0003-1483-3890, Ghosh, Adhideb; https://orcid.org/0000-0002-5160-4571, Bundschuh, Nicola, Hinte, Laura; https://orcid.org/0000-0002-4226-0009, Petrosyan, Eduard, von Meyenn, Ferdinand; https://orcid.org/0000-0001-9920-3075, and Bar-Nur, Ori; https://orcid.org/0000-0002-6466-3124

Abstract

Transient MyoD overexpression in concert with small molecule treatment reprograms mouse fibroblasts into induced myogenic progenitor cells (iMPCs). However, the molecular landscape and mechanisms orchestrating this cellular conversion remain unknown. Here, we undertook an integrative multiomics approach to delineate the process of iMPC reprogramming in comparison to myogenic transdifferentiation mediated solely by MyoD. Using transcriptomics, proteomics, and genome-wide chromatin accessibility assays, we unravel distinct molecular trajectories that govern the two processes. Notably, only iMPC reprogramming is characterized by gradual up-regulation of muscle stem cell markers, unique signaling pathways, and chromatin remodelers in conjunction with exclusive chromatin opening in core myogenic promoters. In addition, we determine that the Notch pathway is indispensable for iMPC formation and self-renewal and further use the Notch ligand Dll1 to homogeneously propagate iMPCs. Collectively, this study charts divergent molecular blueprints for myogenic transdifferentiation or reprogramming and underpins the heightened capacity of iMPCs for capturing myogenesis ex vivo.

Published
2022

41. Multiomic profiling of the acute stress response in the mouse hippocampus

Author

von Ziegler, Lukas M, Floriou-Servou, Amalia; https://orcid.org/0000-0002-5090-4900, Waag, Rebecca; https://orcid.org/0000-0001-5103-2860, Das Gupta, Rebecca R; https://orcid.org/0000-0003-3456-9396, Sturman, Oliver, Gapp, Katharina; https://orcid.org/0000-0002-9622-1478, Maat, Christina A, Kockmann, Tobias; https://orcid.org/0000-0002-1847-885X, Lin, Han-Yu; https://orcid.org/0000-0002-7294-3652, Duss, Sian N; https://orcid.org/0000-0003-0212-0324, Privitera, Mattia; https://orcid.org/0000-0002-5660-5901, Hinte, Laura; https://orcid.org/0000-0002-4226-0009, von Meyenn, Ferdinand; https://orcid.org/0000-0001-9920-3075, Zeilhofer, Hanns Ulrich; https://orcid.org/0000-0001-6954-4629, Germain, Pierre-Luc; https://orcid.org/0000-0003-3418-4218, Bohacek, Johannes; https://orcid.org/0000-0002-8442-653X, von Ziegler, Lukas M, Floriou-Servou, Amalia; https://orcid.org/0000-0002-5090-4900, Waag, Rebecca; https://orcid.org/0000-0001-5103-2860, Das Gupta, Rebecca R; https://orcid.org/0000-0003-3456-9396, Sturman, Oliver, Gapp, Katharina; https://orcid.org/0000-0002-9622-1478, Maat, Christina A, Kockmann, Tobias; https://orcid.org/0000-0002-1847-885X, Lin, Han-Yu; https://orcid.org/0000-0002-7294-3652, Duss, Sian N; https://orcid.org/0000-0003-0212-0324, Privitera, Mattia; https://orcid.org/0000-0002-5660-5901, Hinte, Laura; https://orcid.org/0000-0002-4226-0009, von Meyenn, Ferdinand; https://orcid.org/0000-0001-9920-3075, Zeilhofer, Hanns Ulrich; https://orcid.org/0000-0001-6954-4629, Germain, Pierre-Luc; https://orcid.org/0000-0003-3418-4218, and Bohacek, Johannes; https://orcid.org/0000-0002-8442-653X

Abstract

The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief swim exposure to trigger an acute stress response in mice, which transiently increases anxiety, without leading to lasting maladaptive changes. Using multiomic profiling, such as proteomics, phospho-proteomics, bulk mRNA-, single-nuclei mRNA-, small RNA-, and TRAP-sequencing, we characterize the acute stress-induced molecular events in the mouse hippocampus over time. Our results show the complexity and specificity of the response to acute stress, highlighting both the widespread changes in protein phosphorylation and gene transcription, and tightly regulated protein translation. The observed molecular events resolve efficiently within four hours after initiation of stress. We include an interactive app to explore the data, providing a molecular resource that can help us understand how acute stress impacts brain function in response to stress.

Published
2022

42. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

Author

Belgardt, Bengt-Frederik, Ahmed, Kashan, Spranger, Martina, Latreille, Mathieu, Denzler, Remy, Kondratiuk, Nadiia, von Meyenn, Ferdinand, Villena, Felipe Nunez, Herrmanns, Karolin, Bosco, Domenico, Kerr-Conte, Julie, Pattou, Francois, Rulicke, Thomas, and Stoffel, Markus

Subjects
Pancreatic beta cells -- Physiological aspects -- Genetic aspects -- Research, MicroRNA -- Physiological aspects -- Research, Type 2 diabetes -- Development and progression -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Pancreatic beta cell death is a hallmark of type 1 (T1D) and type 2 (T2D) diabetes, but the molecular mechanisms underlying this aspect of diabetic pathology are poorly understood. Here we report that expression of the microRNA (miR)-200 family is strongly induced in islets of diabetic mice and that beta cell-specific overexpression of miR-200 in mice is sufficient to induce beta cell apoptosis and lethal T2D. Conversely, mir-200 ablation in mice reduces beta cell apoptosis and ameliorates T2D. We show that miR-200 negatively regulates a conserved anti-apoptotic and stress-resistance network that includes the essential beta cell chaperone Dnajc3 (also known as p58IPK) and the caspase inhibitor Xiap. We also observed that mir-200 dosage positively controls activation of the tumor suppressor Trp53 and thereby creates a pro-apoptotic gene-expression signature found in islets of diabetic mice. Consequently, miR-200-induced T2D is suppressed by interfering with the signaling of Trp53 and Bax, a proapoptotic member of the B cell lymphoma 2 protein family. Our results reveal a crucial role for the miR-200 family in beta cell survival and the pathophysiology of diabetes., Adequate insulin secretion from pancreatic beta cells is necessary to maintain blood glucose levels within a physiological range. During the development of T2D, insulin secretion becomes insufficient to normalize blood [...]

Published
2015
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44. Sind nutrigenetische Tests bereit für den Alltag?

Author

van der Horst, Klazine, von Meyenn, Ferdinand, Rezzi, Serge, and Vergères, Guy

Subjects
RZ Other systems of medicine, RA0421 Public health. Hygiene. Preventive Medicine
Abstract

Eine Familie sitzt im Restaurant MyFood und möchte bestellen (Abbildung). Ungewöhnlich ist nur, dass die Bestellung von einem Wissenschafter aufgenommen wird, der den einzelnen Familien- mitgliedern, abgestimmt auf ihr genetisches Profil, unterschiedliche Getränke und Speisen empfiehlt, und dass im Hintergrund ein Labor zu sehen ist. Ist diese Szene Science oder Fiction? Eigentlich müssen das Labor und der Wissenschafter nur gedanklich auf die andere Strassenseite gebracht werden, dann lässt sich erahnen, dass die auf das genetische Profil gestützte personali- sierte Ernährung bereits gängige Wissenschaft und Realität ist. Die Autoren dieses Artikels möchten eine kritische Sicht auf dieses Thema ermöglichen und dabei den Aspekt von Adipositas (Fettleibigkeit) beleuchten.

Published
2022
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46. Additional file 1 of H3K18 lactylation marks tissue-specific active enhancers

Author

Galle, Eva, Wong, Chee-Wai, Ghosh, Adhideb, Desgeorges, Thibaut, Melrose, Kate, Hinte, Laura C., Castellano-Castillo, Daniel, Engl, Magdalena, de Sousa, Joao Agostinho, Ruiz-Ojeda, Francisco Javier, De Bock, Katrien, Ruiz, Jonatan R., and von Meyenn, Ferdinand

Abstract

Additional file 1: Supplemental figures. Fig S1, Fig S2, Fig S3, Fig S4, Fig S5, Fig S6, Fig S7, Fig S8.

Published
2022
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47. Additional file 2 of H3K18 lactylation marks tissue-specific active enhancers

Author

Galle, Eva, Wong, Chee-Wai, Ghosh, Adhideb, Desgeorges, Thibaut, Melrose, Kate, Hinte, Laura C., Castellano-Castillo, Daniel, Engl, Magdalena, de Sousa, Joao Agostinho, Ruiz-Ojeda, Francisco Javier, De Bock, Katrien, Ruiz, Jonatan R., and von Meyenn, Ferdinand

Abstract

Additional file 2: Uncropped western blot images. Cropped images used in Fig. 1A and Fig S1B.

Published
2022
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49. Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells

Author

Kim, Inseon, Ghosh, Adhideb, Bundschuh, Nicola, Hinte, Laura, von Meyenn, Ferdinand, and Bar-Nur, Ori

Abstract

Transient MyoD overexpression in concert with small molecules treatment reprograms mouse fibroblasts into induced myogenic progenitor cells (iMPCs). However, the molecular landscape and mechanisms orchestrating this cellular conversion remain unknown. Here, we undertook an integrative multi-omics approach to delineate the process of iMPC reprogramming in comparison to myogenic transdifferentiation mediated solely by MyoD. Utilizing transcriptomics, proteomics and genome-wide chromatin accessibility assays, we unravel distinct molecular trajectories which govern the two processes. Notably, iMPC reprogramming is characterized by gradual upregulation of stem and progenitor cell markers, unique signaling pathways, chromatin remodelers and cell cycle regulators which manifest via rewiring of the chromatin in core myogenic promoters. Furthermore, we determine that only iMPC reprogramming is mediated by Notch pathway activation, which is indispensable for iMPC formation and self-renewal. Collectively, this study charts divergent molecular blueprints for myogenic transdifferentiation or reprogramming and underpins the heightened capacity of iMPCs in capturing myogenesis ex vivo.

Published
2021

50. Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author

Sun, Wenfei, Dong, Hua, Becker, Anton S., Dapito, Dianne H., Modica, Salvatore, Grandl, Gerald, Opitz, Lennart, Efthymiou, Vissarion, Straub, Leon G., Sarker, Gitalee, Balaz, Miroslav, Balazova, Lucia, Perdikari, Aliki, Kiehlmann, Elke, Bacanovic, Sara, Zellweger, Caroline, Peleg-Raibstein, Daria, Pelczar, Pawel, Reik, Wolf, Burger, Irene A., von Meyenn, Ferdinand, and Wolfrum, Christian

Published
2018
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