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3 results on '"von Brandis, Kari Mette Langerød"'

1. Comparing 5-Year Survival Rates Before and After Re-stratification of Stage I–III Right-Sided Colon Cancer Patients by Establishing the Presence/Absence of Occult Tumor Cells and Lymph Node Metastases in the Different Levels of Surgical Dissection

Author

Banipal, G.S., primary, Stimec, B.V., additional, Andersen, S.N., additional, Faerden, A.E., additional, Edwin, B., additional, Baral, J., additional, Nesgaard, J.M., additional, Benth, J. Šaltytė, additional, Ignjatovic, D., additional, Oresland, Tom, additional, Bakka, Arne O., additional, Thorsen, Yngve, additional, Negaard, Anne, additional, Jacobsen, Russel, additional, von Brandis, Kari Mette Langerød, additional, Hansen, Tania, additional, Suhrke, Pål, additional, Luzon, Javier, additional, Sevinç, Baris, additional, Andersen, Bjarte Tidemann, additional, Bergamaschi, Roberto, additional, Pullig, Frieder, additional, Schneider, Ulrich, additional, Ruiz, Marcos Gomez, additional, Kjaestad, Erik, additional, Bemanian, Vahid, additional, Dyrbekk, Anne Pernille H., additional, Zivanovic, Vladimir, additional, Schultz, Johannes Kurt, additional, Augestad, Knut Magne, additional, and Hamre, Hanne Marie, additional

Published
2022
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2. Interactions of occult tumor spread and surgical technique on overall and disease-free survival in patients operated for stage I and II right-sided colon cancer.

Author

Banipal, G. S., Stimec, B. V., Andersen, S. N., Faerden, A. E., Edwin, B., Baral, J., Benth, J. Šaltytė, Ignjatovic, D., The RCC study group, Oresland, Tom, Bakka, Arne O, Thorsen, Yngve, Negaard, Anne, Nesgaard, Jens Marius, Jacobsen, Russel, von Brandis, Kari Mette Langerød, Hansen, Tania, Suhrke, Pål, Luzon, Javier Armando, and Sevinç, Barış

Subjects
OVERALL survival, METASTASIS, PROGRESSION-free survival, COLON cancer, PROGNOSIS
Abstract

Purpose: To determine if "medial to lateral" (ML) dissection with devascularization first is superior to "lateral to medial" (LM) dissection regarding numbers of lymph node micro metastases (MM) and isolated tumor cells (ITC) as well as 5-year disease-free (5YDFS) and 5-year overall survival (5YOS) in stage I/II right-sided colon cancer. Methods: Two datasets are used. ML group consists of consecutive stage I/II patients from a prospective trial. LM group is the original dataset from a previous publication. All harvested lymph nodes are examined with monoclonal antibody CAM 5.2 (immunohistochemically). Lymph node harvest and 5YOS/5YDFS were compared between ML/LM groups, stage I/II tumors and MM/ITC presence/absence. Results: 117 patients included ML:51, LM:66. MM/ITC positive in ML 37.3% (19/51), LM 31.8% (21/66) p = 0.54. The 5YDFS for patients in ML 70.6% and LM 69.7%, p = 0.99, 5YOS: 74.5% ML and 71.2% LM (p = 0.73). No difference in 5YDFS/5YOS between groups for Stage I/II tumors; however, LM group had an excess of early tumors (16) when compared to ML group, while lymph node harvest was significantly higher in ML group (p < 0.01) 15.1 vs 26.7. 5YDFS and 5YOS stratified by MM/ITC presence/absence was 67.5%/71.4%, p = 0.63, and 75.0%/71.4%, p = 0.72, respectively. Death due to recurrence in MM/ITC positive was significantly higher than MM/ITC negative (p = 0.012). Conclusion: Surgical technique does not influence numbers of MM/ITC or 5YDFS/5YOS. Presence of MM/ITC does not affect 5YOS/5YDFS but can be a potential prognostic factor for death due to recurrence. Clinical trial: Safe Radical D3 Right Hemicolectomy for Cancer through Preoperative Biphasic Multi-Detector Computed Tomography (MDCT) Angiography" registered at http://clinicaltrials.gov/ct2/show/NCT01351714. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Interactions of occult tumor spread and surgical technique on overall and disease-free survival in patients operated for stage I and II right-sided colon cancer

Author

Solveig Norheim Andersen, J. Šaltytė Benth, Bojan V. Stimec, Arne E. Faerden, J Baral, Bjørn Edwin, Dejan Ignjatovic, G S Banipal, Oresland, Tom, Bakka, Arne O, Thorsen, Yngve, Negaard, Anne, Nesgaard, Jens Marius, Jacobsen, Russel, von Brandis, Kari Mette Langerød, Hansen, Tania, Suhrke, Pål, Luzon, Javier Armando, Sevinç, Barış, Andersen, Bjarte Tidemann, Bergamaschi, Roberto, Schneider, Ulrich, Ruiz, Marcos Gomez, Kjaestad, Erik, Bemanian, Vahid, Ghotbi, Jacob, and Dyrbekk, Anne Pernille H.

Subjects
Male, Cancer Research, Colorectal cancer, Isolated tumor cells, Occult tumor spread, Micro metastases, Disease-Free Survival, Humans, Medicine, In patient, ddc:610, Stage I/II right-side colon cancer, Lymph node, Colectomy, Aged, Laparotomy, medicine.diagnostic_test, business.industry, Cancer, General Medicine, Middle Aged, medicine.disease, Occult, Dissection, medicine.anatomical_structure, Oncology, D3 right colectomy, Lymphatic Metastasis, Colonic Neoplasms, Angiography, Female, Lymph, Original Article – Cancer Research, business, Nuclear medicine
Abstract

Purpose To determine if “medial to lateral” (ML) dissection with devascularization first is superior to “lateral to medial” (LM) dissection regarding numbers of lymph node micro metastases (MM) and isolated tumor cells (ITC) as well as 5-year disease-free (5YDFS) and 5-year overall survival (5YOS) in stage I/II right-sided colon cancer. Methods Two datasets are used. ML group consists of consecutive stage I/II patients from a prospective trial. LM group is the original dataset from a previous publication. All harvested lymph nodes are examined with monoclonal antibody CAM 5.2 (immunohistochemically). Lymph node harvest and 5YOS/5YDFS were compared between ML/LM groups, stage I/II tumors and MM/ITC presence/absence. Results 117 patients included ML:51, LM:66. MM/ITC positive in ML 37.3% (19/51), LM 31.8% (21/66) p = 0.54. The 5YDFS for patients in ML 70.6% and LM 69.7%, p = 0.99, 5YOS: 74.5% ML and 71.2% LM (p = 0.73). No difference in 5YDFS/5YOS between groups for Stage I/II tumors; however, LM group had an excess of early tumors (16) when compared to ML group, while lymph node harvest was significantly higher in ML group (p p = 0.63, and 75.0%/71.4%, p = 0.72, respectively. Death due to recurrence in MM/ITC positive was significantly higher than MM/ITC negative (p = 0.012). Conclusion Surgical technique does not influence numbers of MM/ITC or 5YDFS/5YOS. Presence of MM/ITC does not affect 5YOS/5YDFS but can be a potential prognostic factor for death due to recurrence. Clinical trial Safe Radical D3 Right Hemicolectomy for Cancer through Preoperative Biphasic Multi-Detector Computed Tomography (MDCT) Angiography” registered at http://clinicaltrials.gov/ct2/show/NCT01351714 .

Published
2021

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