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928 results on '"von Andrian, Ulrich H."'

6. Slow integrin-dependent migration organizes networks of tissue-resident mast cells

Author

Kaltenbach, Lukas, Martzloff, Paloma, Bambach, Sarah K., Aizarani, Nadim, Mihlan, Michael, Gavrilov, Alina, Glaser, Katharina M., Stecher, Manuel, Thünauer, Roland, Thiriot, Aude, Heger, Klaus, Kierdorf, Katrin, Wienert, Stephan, von Andrian, Ulrich H., Schmidt-Supprian, Marc, Nerlov, Claus, Klauschen, Frederick, Roers, Axel, Bajénoff, Marc, Grün, Dominic, and Lämmermann, Tim

Published
2023
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9. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

Author

Biton, Moshe, Haber, Adam L, Rogel, Noga, Burgin, Grace, Beyaz, Semir, Schnell, Alexandra, Ashenberg, Orr, Su, Chien-Wen, Smillie, Christopher, Shekhar, Karthik, Chen, Zuojia, Wu, Chuan, Ordovas-Montanes, Jose, Alvarez, David, Herbst, Rebecca H, Zhang, Mei, Tirosh, Itay, Dionne, Danielle, Nguyen, Lan T, Xifaras, Michael E, Shalek, Alex K, von Andrian, Ulrich H, Graham, Daniel B, Rozenblatt-Rosen, Orit, Shi, Hai Ning, Kuchroo, Vijay, Yilmaz, Omer H, Regev, Aviv, and Xavier, Ramnik J

Subjects
Biodefense, Digestive Diseases, Regenerative Medicine, Stem Cell Research, Prevention, Vaccine Related, Stem Cell Research - Nonembryonic - Non-Human, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Animals, Cell Differentiation, Cell Self Renewal, Cytokines, Epithelial Cells, Female, Histocompatibility Antigens Class II, Immune System, Interleukin-10, Intestines, Male, Mice, Mice, Inbred C57BL, Organoids, Receptors, G-Protein-Coupled, Salmonella enterica, Stem Cells, T-Lymphocytes, Helper-Inducer, ISCs, MHC class II, MHCII, T helper, T regulatory, T(reg), Th, epithelial differentiation, gut biology, intestinal stem cells, mucosal immunity, scRNA-seq, single cell RNA-seq, stem cell renewal, tuft cells, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC fate or the balance between self-renewal and differentiation. Here, we use single-cell RNA sequencing (scRNA-seq) to identify MHC class II (MHCII) machinery enrichment in two subsets of Lgr5+ ISCs. We show that MHCII+ Lgr5+ ISCs are non-conventional antigen-presenting cells in co-cultures with CD4+ T helper (Th) cells. Stimulation of intestinal organoids with key Th cytokines affects Lgr5+ ISC renewal and differentiation in opposing ways: pro-inflammatory signals promote differentiation, while regulatory cells and cytokines reduce it. In vivo genetic perturbation of Th cells or MHCII expression on Lgr5+ ISCs impacts epithelial cell differentiation and IEC fate during infection. These interactions between Th cells and Lgr5+ ISCs, thus, orchestrate tissue-wide responses to external signals.

Published
2018

10. Constitutive immune surveillance of nasal mucosa by three neutrophil subsets with distinct origin, phenotype, and function

Author

Gonzalez, Rodrigo J., primary, Hanč, Pavel, additional, Alvarez, David, additional, Kazer, Samuel W., additional, Messou, Marie-Angele, additional, Mazo, Irina B., additional, Matysiak Match, Colette, additional, Garg, Rohit, additional, Helble, Jennifer D., additional, Pallis, Paris, additional, Ende, Rachel, additional, Basset, Alan, additional, Malley, Rick, additional, Derre, Isabelle, additional, Starnbach, Michael N., additional, and von Andrian, Ulrich H., additional

Published
2024
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12. Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice

Author

Kochappan, Ruby, Cao, Enyuan, Han, Sifei, Hu, Luojuan, Quach, Tim, Senyschyn, Danielle, Ferreira, Vilena Ivanova, Lee, Given, Leong, Nathania, Sharma, Garima, Lim, Shea Fern, Nowell, Cameron J., Chen, Ziqi, von Andrian, Ulrich H., Bonner, Daniel, Mintern, Justine D., Simpson, Jamie S., Trevaskis, Natalie L., and Porter, Christopher J.H.

Published
2021
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16. Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche.

Author

Krause, Daniela S, Lazarides, Katherine, Lewis, Juliana B, von Andrian, Ulrich H, and Van Etten, Richard A

Subjects
Animals, Bone Marrow: pathology, Bone Marrow Cells: pathology, Cell Movement: genetics, Cells, Cultured, Fusion Proteins, bcr-abl: genetics, metabolism, HEK293 Cells, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive: genetics, pathology, Ligands, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Invasiveness, Neoplastic Stem Cells: metabolism, pathology, physiology, Selectins: physiology, Stem Cell Niche
Abstract

We investigated adhesion pathways that contribute to engraftment of breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL1)-induced chronic myelogenous leukemia (CML)-like myeloproliferative neoplasia in a mouse retroviral transduction/transplantation model. Compared with normal stem/progenitor cells, BCR-ABL1(+) progenitors had similar expression of very late antigen-4 (VLA4), VLA5, leukocyte functional antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selectin. Whereas vascular cell adhesion molecule-1 and P-selectin were not required, deficiency of E-selectin in the recipient bone marrow endothelium significantly reduced engraftment by BCR-ABL1-expressing stem cells following intravenous injection, with leukemogenesis restored by direct intrafemoral injection. BCR-ABL1-expressing cells deficient for PSGL-1 or the selectin ligand-synthesizing enzymes core-2 β1,6-N-acetylglucosaminyltransferase or fucosyltransferases IV/VII were impaired for engraftment, and destruction of selectin ligands on leukemic progenitors by neuraminidase reduced engraftment. BCR-ABL1-expressing L-selectin-deficient progenitors were also defective in homing and engraftment, with leukemogenesis rescued by coexpression of chimeric E/L-selectin. Antibody to L-selectin decreased the engraftment of BCR-ABL1-transduced stem cells. These results establish that BCR-ABL1(+) leukemic stem cells rely to a greater extent on selectins and their ligands for homing and engraftment than do normal stem cells. Selectin blockade is a novel strategy to exploit differences between normal and leukemic stem cells that may be beneficial in autologous transplantation for CML and perhaps other leukemias.

Published
2014

17. HIV-infected T cells are migratory vehicles for viral dissemination

Author

Murooka, Thomas T, Deruaz, Maud, Marangoni, Francesco, Vrbanac, Vladimir D, Seung, Edward, von Andrian, Ulrich H, Tager, Andrew M, Luster, Andrew D, and Mempel, Thorsten R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Infectious Diseases, Human Fetal Tissue, Aetiology, 2.1 Biological and endogenous factors, Infection, Animals, CD4-Positive T-Lymphocytes, Cell Movement, Cells, Cultured, Disease Models, Animal, Female, Giant Cells, HIV, HIV Infections, Humans, Lymph Nodes, Mice, Mice, Inbred NOD, Mice, SCID, Mice, Transgenic, General Science & Technology
Abstract

After host entry through mucosal surfaces, human immunodeficiency virus-1 (HIV-1) disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally during the early stages of transmission and systemically during subsequent dissemination are not known. In vitro studies suggest that the formation of virological synapses during stable contacts between infected and uninfected T cells greatly increases the efficiency of viral transfer. It is unclear, however, whether T-cell contacts are sufficiently stable in vivo to allow for functional synapse formation under the conditions of perpetual cell motility in epithelial and lymphoid tissues. Here, using multiphoton intravital microscopy, we examine the dynamic behaviour of HIV-infected T cells in the lymph nodes of humanized mice. We find that most productively infected T cells migrate robustly, resulting in their even distribution throughout the lymph node cortex. A subset of infected cells formed multinucleated syncytia through HIV envelope-dependent cell fusion. Both uncoordinated motility of syncytia and adhesion to CD4(+) lymph node cells led to the formation of long membrane tethers, increasing cell lengths to up to ten times that of migrating uninfected T cells. Blocking the egress of migratory T cells from the lymph nodes into efferent lymph vessels, and thus interrupting T-cell recirculation, limited HIV dissemination and strongly reduced plasma viraemia. Thus, we have found that HIV-infected T cells are motile, form syncytia and establish tethering interactions that may facilitate cell-to-cell transmission through virological synapses. Migration of T cells in lymph nodes therefore spreads infection locally, whereas their recirculation through tissues is important for efficient systemic viral spread, suggesting new molecular targets to antagonize HIV infection.

Published
2012

18. Association between Bisphosphonate use and COVID-19 related outcomes

Author

Thompson, Jeffrey, primary, Wang, Yidi, additional, Dreischulte, Tobias, additional, Barreiro, Olga, additional, Gonzalez, Rodrigo J, additional, Hanč, Pavel, additional, Matysiak, Colette, additional, Neely, Harold R, additional, Rottenkolber, Marietta, additional, Haskell, Thomas, additional, Endres, Stefan, additional, and von Andrian, Ulrich H, additional

Published
2023
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20. Cosmc controls B cell homing

Author

Zeng, Junwei, Eljalby, Mahmoud, Aryal, Rajindra P., Lehoux, Sylvain, Stavenhagen, Kathrin, Kudelka, Matthew R., Wang, Yingchun, Wang, Jianmei, Ju, Tongzhong, von Andrian, Ulrich H., and Cummings, Richard D.

Published
2020
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23. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells.

Author

Krause, Daniela S, Lazarides, Katherine, von Andrian, Ulrich H, and Van Etten, Richard A

Subjects
Animals, Antigens, CD44: biosynthesis, Bone Marrow Cells: cytology, Cell Line, Tumor, Cohort Studies, Fusion Proteins, bcr-abl: chemistry, physiology, Hematopoietic Stem Cells: cytology, Humans, Leukemia: metabolism, pathology, Mice, Retroviridae: genetics, Stem Cell Transplantation: methods, Stem Cells: cytology, metabolism, Transplantation, Autologous
Abstract

In individuals with chronic myeloid leukemia (CML) treated by autologous hematopoietic stem cell (HSC) transplantation, malignant progenitors in the graft contribute to leukemic relapse, but the mechanisms of homing and engraftment of leukemic CML stem cells are unknown. Here we show that CD44 expression is increased on mouse stem-progenitor cells expressing BCR-ABL and that CD44 contributes functional E-selectin ligands. In a mouse retroviral transplantation model of CML, BCR-ABL1-transduced progenitors from CD44-mutant donors are defective in homing to recipient marrow, resulting in decreased engraftment and impaired induction of CML-like myeloproliferative disease. By contrast, CD44-deficient stem cells transduced with empty retrovirus engraft as efficiently as do wild-type HSCs. CD44 is dispensable for induction of acute B-lymphoblastic leukemia by BCR-ABL, indicating that CD44 is specifically required on leukemic cells that initiate CML. The requirement for donor CD44 is bypassed by direct intrafemoral injection of BCR-ABL1-transduced CD44-deficient stem cells or by coexpression of human CD44. Antibody to CD44 attenuates induction of CML-like leukemia in recipients. These results show that BCR-ABL-expressing leukemic stem cells depend to a greater extent on CD44 for homing and engraftment than do normal HSCs, and argue that CD44 blockade may be beneficial in autologous transplantation in CML.

Published
2006

24. Lymphocyte–HEV Interactions in Lymph Nodes of a Sulfotransferase-deficient Mouse

Author

van Zante, Annemieke, Gauguet, Jean-Marc, Bistrup, Annette, Tsay, Durwin, von Andrian, Ulrich H, and Rosen, Steven D

Subjects
Biomedical and Clinical Sciences, Immunology, Inflammatory and immune system, Animals, Enzyme-Linked Immunosorbent Assay, Ligands, Lymph Nodes, Lymphocytes, Mice, Mice, Knockout, Selectins, Sulfotransferases, Venules, lymphocyte homing, L-selectin, sulfotransferase, endothelium, MECA79, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

The interaction of L-selectin expressed on lymphocytes with sulfated sialomucin ligands such as CD34 and GlyCAM-1 on high endothelial venules (HEV) of lymph nodes results in lymphocyte rolling and is essential for lymphocyte recruitment. HEC-GlcNAc6ST-deficient mice lack an HEV-restricted sulfotransferase with selectivity for the C-6 position of N-acetylglucosamine (GlcNAc). HEC-GlcNAc6ST-/- animals exhibit faster lymphocyte rolling and reduced lymphocyte sticking in HEV, accounting for the diminished lymphocyte homing. Isolated CD34 and GlyCAM-1 from HEC-GlcNAc6ST-/- animals incorporate approximately 70% less sulfate than ligands from wild-type animals. Furthermore, these ligands exhibit a comparable reduction of the epitope recognized by MECA79, a function-blocking antibody that reacts with L-selectin ligands in a GlcNAc-6-sulfate-dependent manner. Whereas MECA79 dramatically inhibits lymphocyte rolling and homing to lymph nodes in wild-type mice, it has no effect on HEC-GlcNAc6ST-/- mice. In contrast, in vitro rolling on purified GlyCAM-1 from HEC-GlcNAc6ST-/- mice, although greatly diminished compared with that on the wild-type ligand, is inhibited by MECA79. Our results demonstrate that HEC-GlcNAc6ST contributes predominantly, but not exclusively, to the sulfation of HEV ligands for L-selectin and that alternative, non-MECA79-reactive ligands are present in the absence of HEC-GlcNAc6ST.

Published
2003

26. Primary nasal viral infection rewires the tissue-scale memory response

Author

Kazer, Samuel W., primary, Match, Colette Matysiak, additional, Langan, Erica M., additional, Messou, Marie-Angèle, additional, LaSalle, Thomas J., additional, O’Leary, Elise, additional, Marbourg, Jessica, additional, Naughton, Katherine, additional, von Andrian, Ulrich H., additional, and Ordovas-Montanes, Jose, additional

Published
2023
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27. Supplementary Figure S6 from Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

Author

Dougan, Michael, primary, Ingram, Jessica R., primary, Jeong, Hee-Jin, primary, Mosaheb, Munir M., primary, Bruck, Patrick T., primary, Ali, Lestat, primary, Pishesha, Novalia, primary, Blomberg, Olga, primary, Tyler, Paul M., primary, Servos, Mariah M., primary, Rashidian, Mohammad, primary, Nguyen, Quang-De, primary, von Andrian, Ulrich H., primary, Ploegh, Hidde L., primary, and Dougan, Stephanie K., primary

Published
2023
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28. Data from Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

Author

Dougan, Michael, primary, Ingram, Jessica R., primary, Jeong, Hee-Jin, primary, Mosaheb, Munir M., primary, Bruck, Patrick T., primary, Ali, Lestat, primary, Pishesha, Novalia, primary, Blomberg, Olga, primary, Tyler, Paul M., primary, Servos, Mariah M., primary, Rashidian, Mohammad, primary, Nguyen, Quang-De, primary, von Andrian, Ulrich H., primary, Ploegh, Hidde L., primary, and Dougan, Stephanie K., primary

Published
2023
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29. Supplementary Figure Legends from Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

Author

Dougan, Michael, primary, Ingram, Jessica R., primary, Jeong, Hee-Jin, primary, Mosaheb, Munir M., primary, Bruck, Patrick T., primary, Ali, Lestat, primary, Pishesha, Novalia, primary, Blomberg, Olga, primary, Tyler, Paul M., primary, Servos, Mariah M., primary, Rashidian, Mohammad, primary, Nguyen, Quang-De, primary, von Andrian, Ulrich H., primary, Ploegh, Hidde L., primary, and Dougan, Stephanie K., primary

Published
2023
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31. Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

Author

Di Pilato, Mauro, primary, Gao, Yun, additional, Sun, Yi, additional, Fu, Amina, additional, Grass, Carina, additional, Seeholzer, Thomas, additional, Feederle, Regina, additional, Mazo, Irina, additional, Kazer, Samuel W., additional, Litchfield, Kevin, additional, von Andrian, Ulrich H., additional, Mempel, Thorsten R., additional, Jenkins, Russell W., additional, Krappmann, Daniel, additional, and Keller, Peter, additional

Published
2023
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35. Contributors

Author

Abdel-Wahab, Omar, primary, Abrahm, Janet L., additional, Adams, Sharon, additional, Adewoye, Adeboye H., additional, Allen, Carl, additional, Ambinder, Richard F., additional, Anasetti, Claudio, additional, Anastasi, John, additional, Anderson, Julia A., additional, Antin, Joseph H., additional, Antony, Aśok C., additional, Araten, David J., additional, Armand, Philippe, additional, Armstrong, Gillian, additional, Armstrong, Scott A., additional, Arnold, Donald M., additional, Artz, Andrew S., additional, Awan, Farrukh T., additional, Baglin, Trevor P., additional, Benson, Don M., additional, Benz, Edward J., additional, Berliner, Nancy, additional, Bhagat, Govind, additional, Bhardwaj, Nina, additional, Bhatia, Ravi, additional, Bhatia, Smita, additional, Bhatt, Mihir D., additional, Bhatt, Vijaya Raj, additional, Bitan, Menachem, additional, Blinderman, Craig D., additional, Bollard, Catherine M., additional, Braun, Benjamin S., additional, Brenner, Malcolm K., additional, Brittenham, Gary M., additional, Brodsky, Robert A., additional, Brown, Myles, additional, Broxmeyer, Hal E., additional, Brummel-Ziedins, Kathleen, additional, Brunner, Andrew M., additional, Buadi, Francis K., additional, Burkhardt, Birgit, additional, Burns, Melissa, additional, Byrd, John C., additional, Caimi, Paolo F., additional, Caligiuri, Michael A., additional, Canavan, Michelle, additional, Cantor, Alan B., additional, Carcao, Manuel, additional, Carroll, Michael C., additional, Carty, Shannon A., additional, Castillo, Jorge J., additional, Chan, Anthony K.C., additional, Chapin, John, additional, Chiu, April, additional, Chute, John P., additional, Clark, David B., additional, Coates, Thomas D., additional, Cogle, Christopher R., additional, Connell, Nathan T., additional, Cooke, Elizabeth, additional, Cooley, Sarah, additional, Corradini, Paolo, additional, Creager, Mark A., additional, Creger, Richard J., additional, Cromwell, Caroline, additional, Crowther, Mark A., additional, Cushing, Melissa M., additional, Cutler, Corey, additional, Dang, Chi V., additional, Danial, Nika N., additional, Dave, Sandeep S., additional, DeCaprio, James A., additional, Dinauer, Mary C., additional, Dinner, Shira, additional, Diz-Küçükkaya, Reyhan, additional, Dodd, Roger Y., additional, Donato, Michele L., additional, Dorshkind, Kenneth, additional, Dotti, Gianpietro, additional, Dror, Yigal, additional, Dunleavy, Kieron, additional, Dvorak, Christopher C., additional, Ebert, Benjamin L., additional, Eck, Michael J., additional, Eikelboom, John W., additional, Epperla, Narendranath, additional, Ershler, William B., additional, Evans, William E., additional, Faderl, Stefan, additional, Ferrara, James L.M., additional, Filipovich, Alexandra Hult, additional, Fischer, Martin, additional, Fredenburgh, James C., additional, Friedman, Kenneth D., additional, Fuchs, Ephraim, additional, Fuller, Stephen J., additional, Gailani, David, additional, Galipeau, Jacques, additional, Gallagher, Patrick G., additional, Ganapathi, Karthik A., additional, Gardner, Lawrence B., additional, Gee, Adrian P., additional, Gerson, Stanton L., additional, Gertz, Morie A., additional, Giardina, Patricia J., additional, Gibson, Christopher J., additional, Golan, Karin, additional, Golub, Todd R., additional, Gonzales, Matthew J., additional, Gotlib, Jason, additional, Gottschalk, Stephen, additional, Grant, Marianne A., additional, Graubert, Timothy A., additional, Gregg, Xylina T., additional, Gribben, John G., additional, Gross, Dawn M., additional, Gruber, Tanja A., additional, Guitart, Joan, additional, Gurbuxani, Sandeep, additional, Gur-Cohen, Shiri, additional, Gutierrez, Alejandro, additional, Hamadani, Mehdi, additional, Hari, Parameswaran N., additional, Hartwig, John H., additional, Hayman, Suzanne R., additional, Hayward, Catherine P.M., additional, Hebbel, Robert P., additional, Heslop, Helen E., additional, Hillis, Christopher, additional, Hillyer, Christopher D., additional, Ho, Karin, additional, Hockenbery, David M., additional, Hoffman, Ronald, additional, Hogg, Kerstin E., additional, Holtan, Shernan G., additional, Horny, Hans-Peter, additional, Hsu, Yen-Michael S., additional, Hunter, Zachary R., additional, Huntington, James A., additional, Iancu-Rubin, Camelia, additional, Iqbal, Ali, additional, Isenman, David E., additional, Israels, Sara J., additional, Italiano, Joseph E., additional, Jaffe, Elaine S., additional, Jaffer, Iqbal H., additional, Jagannath, Sundar, additional, Jäger, Ulrich, additional, Jain, Nitin, additional, James, Paula, additional, Jeha, Sima, additional, Jordan, Michael B., additional, Josephson, Cassandra D., additional, Jung, Moonjung, additional, Kager, Leo, additional, Kambayashi, Taku, additional, Kanakry, Jennifer A., additional, Kantarjian, Hagop M., additional, Kaplan, Jason, additional, Karafin, Matthew S., additional, Karsan, Aly, additional, Kaufman, Randal J., additional, Kaufman, Richard M., additional, Keller, Frank G., additional, Kelly, Kara M., additional, Kessler, Craig M., additional, Key, Nigel S., additional, Keyzner, Alla, additional, Khandoga, Alexander G., additional, Khanna-Gupta, Arati, additional, Khatib-Massalha, Eman, additional, Klein, Harvey G., additional, Knoechel, Birgit, additional, Kollet, Orit, additional, Konkle, Barbara A., additional, Kontoyiannis, Dimitrios P., additional, Koreth, John, additional, Koretzky, Gary A., additional, Kotecha, Dipak, additional, Kremyanskaya, Marina, additional, Kumari, Anju, additional, Kuzel, Timothy M., additional, Küppers, Ralf, additional, Lacy, Martha Q., additional, Ladas, Elana, additional, Landier, Wendy, additional, Lapid, Kfir, additional, Lapidot, Tsvee, additional, Larson, Peter J., additional, Levi, Marcel, additional, Lewis, Russell E., additional, Liebman, Howard A., additional, Lillicrap, David, additional, Lim, Wendy, additional, Lin, Judith C., additional, Lindblad, Robert, additional, Lip, Gregory Y.H., additional, Little, Jane A., additional, Lohr, Jens G., additional, López, José A., additional, Luscinskas, Francis W., additional, Maciejewski, Jaroslaw P., additional, Majhail, Navneet S., additional, Manches, Olivier, additional, Mandle, Robert J., additional, Mann, Kenneth G., additional, Manno, Catherine S., additional, Marcogliese, Andrea N., additional, Mariani, Guglielmo, additional, Marincola, Francesco M., additional, Mascarenhas, John, additional, Massberg, Steffen, additional, McEver, Rodger P., additional, McGrath, Emer, additional, McKinney, Matthew S., additional, Mehta, Rohtesh S., additional, Mentzer, William C., additional, Merlini, Giampaolo, additional, Merryman, Reid, additional, Michel, Marc, additional, Migliaccio, Anna Rita, additional, Miller, Jeffrey S., additional, Mims, Martha P., additional, Mondoro, Traci Heath, additional, Moorehead, Paul, additional, Muniz, Luciana R., additional, Munshi, Nikhil C., additional, Najfeld, Vesna, additional, Nayak, Lalitha, additional, Nazy, Ishac, additional, Neff, Anne T., additional, Ness, Paul M., additional, Notarangelo, Luigi D., additional, O'Brien, Sarah H., additional, O'Connor, Owen A., additional, O'Donnell, Martin, additional, Olson, Amanda, additional, Orkin, Stuart H., additional, Pai, Menaka, additional, Pai, Sung-Yun, additional, Paidas, Michael, additional, Panch, Sandhya R., additional, Pande, Reena L., additional, Papayannopoulou, Thalia, additional, Parikh, Rahul, additional, Petersdorf, Effie W., additional, Peterson, Shane E., additional, Pittaluga, Stefania, additional, Ponce, Doris M., additional, Popolo, Laura, additional, Prchal, Josef T., additional, Pui, Ching-Hon, additional, Puigserver, Pere, additional, Rak, Janusz, additional, Ramos, Carlos A., additional, Rand, Jacob H., additional, Rand, Margaret L., additional, Rao, Dinesh S., additional, Ravandi, Farhad, additional, Rawlings, David J., additional, Reddy, Pavan, additional, Reding, Mark T., additional, Reiter, Andreas, additional, Rice, Lawrence, additional, Riese, Matthew J., additional, Ritchey, Arthur Kim, additional, Roberts, David J., additional, Roman, Elizabeth, additional, Rooney, Cliona M., additional, Rosen, Steven T., additional, Rosenthal, David S., additional, Rossmann, Marlies P., additional, Rot, Antal, additional, Rowley, Scott D., additional, Rubnitz, Jeffrey E., additional, Rydz, Natalia, additional, Salama, Mohamed E., additional, Sauk, Steven, additional, Saunthararajah, Yogen, additional, Savage, William, additional, Scadden, David, additional, Schaefer, Kristen G., additional, Schiffman, Fred, additional, Schneidewend, Robert, additional, Schrier, Stanley L., additional, Schuchman, Edward H., additional, Scullion, Bridget Fowler, additional, Selvaggi, Kathy J., additional, Senoo, Keitaro, additional, Shaheen, Montaser, additional, Shaz, Beth H., additional, Shelburne, Samuel A., additional, Shpall, Elizabeth J., additional, Shurin, Susan B., additional, Siegal, Deborah, additional, Silberstein, Leslie E., additional, Silberstein, Lev, additional, Silverstein, Roy L., additional, Sloan, Steven R., additional, Smith, Franklin O., additional, Smith, James W., additional, Smith, Katy, additional, Steensma, David P., additional, Steinberg, Martin H., additional, Stock, Wendy, additional, Storry, Jill R., additional, Stramer, Susan L., additional, Strauss, Ronald G., additional, Stroncek, David F., additional, Taylor, Justin, additional, Thota, Swapna, additional, Treon, Steven P., additional, Tulpule, Anil, additional, Valdes, Roberto Ferro, additional, Valent, Peter, additional, Vedantham, Suresh, additional, Vercellotti, Gregory M., additional, Verneris, Michael R., additional, Vichinsky, Elliott P., additional, von Andrian, Ulrich H., additional, Vose, Julie M., additional, Wagner, Andrew J., additional, Wang, Ena, additional, Wang, Jia-huai, additional, Warkentin, Theodore E., additional, Wasserstein, Melissa P., additional, Webster, Ann, additional, Weisdorf, Daniel J., additional, Weitz, Jeffrey I., additional, Westhoff, Connie M., additional, Wheeler, Allison P., additional, Widick, Page, additional, Wiley, James S., additional, William, Basem M., additional, Williams, David A., additional, Wilson, Wyndham H., additional, Wolfe, Joanne, additional, Wolgast, Lucia R., additional, Wood, Deborah, additional, Wu, Jennifer, additional, Yahalom, Joachim, additional, Yee, Donald L., additional, Younes, Anas, additional, Young, Neal S., additional, and Zeller, Michelle P., additional

Published
2018
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37. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

Author

Raslan, Ahmed A., primary, Pham, Tho X., additional, Lee, Jisu, additional, Hong, Jeongmin, additional, Schmottlach, Jillian, additional, Nicolas, Kristina, additional, Dinc, Taha, additional, Bujor, Andreea M., additional, Caporarello, Nunzia, additional, Thiriot, Aude, additional, von Andrian, Ulrich H., additional, Huang, Steven K., additional, Nicosia, Roberto F., additional, Trojanowska, Maria, additional, Varelas, Xaralabos, additional, and Ligresti, Giovanni, additional

Published
2023
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39. Functional mRNA delivery to hematopoietic stem and progenitor cellsin vivo

Author

Alvarez, David, primary, Masse-Ranson, Guillemette, additional, Sedimbi, Saikiran K., additional, Wisti, Phylicia, additional, Rodriguez, Lisa, additional, Santana, Jordan, additional, Manning, Taylor, additional, Towner, Tim, additional, Geilich, Ben, additional, Mihai, Cosmin, additional, Mishra, Ankita, additional, Gurumurthy, Sushma, additional, Frederick, Josh, additional, von Andrian, Ulrich H., additional, Hoggatt, Jonathan, additional, Moore, Melissa J., additional, and Mora, J. Rodrigo, additional

Published
2022
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42. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Author

Ilyinskii, Petr O., Roy, Christopher J., O’Neil, Conlin P., Browning, Erica A., Pittet, Lynnelle A., Altreuter, David H., Alexis, Frank, Tonti, Elena, Shi, Jinjun, Basto, Pamela A., Iannacone, Matteo, Radovic-Moreno, Aleksandar F., Langer, Robert S., Farokhzad, Omid C., von Andrian, Ulrich H., Johnston, Lloyd P.M., and Kishimoto, Takashi Kei

Published
2014
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48. Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels

Author

Sperandio, Markus, Quackenbush, Elizabeth J., Sushkova, Natalia, Altstätter, Johannes, Nussbaum, Claudia, Schmid, Stephan, Pruenster, Monika, Kurz, Angela, Margraf, Andreas, Steppner, Alina, Schweiger, Natalie, Borsig, Lubor, Boros, Ildiko, Krajewski, Nele, Genzel-Boroviczeny, Orsolya, Jeschke, Udo, Frommhold, David, and von Andrian, Ulrich H.

Published
2013
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50. In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria

Author

Geva-Zatorsky, Naama, Alvarez, David, Hudak, Jason E., Reading, Nicola C., Erturk-Hasdemir, Deniz, Dasgupta, Suryasarathi, von Andrian, Ulrich H., and Kasper, Dennis L.

Subjects
Microbiota (Symbiotic organisms) -- Physiological aspects -- Research, Host-bacteria relationships, Biological sciences, Health
Abstract

The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environment. We applied metabolic oligosaccharide engineering and bioorthogonal click chemistry to label various commensal anaerobes, including Bacteroides fragilis, a common and immunologically important commensal. We studied the dissemination of B. fragilis after acute peritonitis and characterized the interactions of the intact microbe and its polysaccharide components in myeloid and B cell lineages. We were able to assess the distribution and colonization of labeled B. fragilis along the intestine, as well as niche competition after coadministration of multiple species of the microbiota. We also fluorescently labeled nine additional commensals (eight anaerobic and one microaerophilic) from three phyla common in the gut--Bacteroidetes, Firmicutes and Proteobacteria--as well as one aerobic pathogen (Staphylococcus aureus). This strategy permits visualization of the anaerobic microbial niche by various methods, including intravital two-photon microscopy and non-invasive whole-body imaging, and can be used to study microbial colonization and host-microbe interactions in real time., The human gastrointestinal tract is densely populated by >10 (13) bacteria of various species, which have evolved to have important roles in human health and disease (1-6). Despite the many [...]

Published
2015
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