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Epilepsy is the chronic non-communicable disease of the nervous system most prevalent in the world. Valproic acid (VPA) is one of the most used drugs in the treatment of epilepsy but with various side effects. One of the organs that can be affected is the testis, where it has been seen that men treated with VPA reduce their fertility rates, in addition to causing endocrine disorders by decreasing androgens and gonadotropins. In animal models, it has been shown to reduce the weights of the glands attached to the male reproductive tract, as well as at the testicular level, decreasing sperm concentration and increasing apoptotic cell count. These effects are because VPA increases reactive oxygen species (ROS), causing damage to macromolecules and affecting all cellular processes sensitive to oxide reduction. Throughout testicular development, in utero, it has been seen that the expression of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase, are lower during early embryonic development, as well as vitamin E (VE) is decreased. Therefore, they are not sufficient to reverse the toxic effects of ROS. The objective of this study was to review the use of VPA during pregnancy, its effect on testicular development, and to explore the potential protective role of vitamin E. [ABSTRACT FROM AUTHOR]

Background: Active bone remodeling processes can be altered by the presence of reactive oxygen species and, therefore, cause leg problems in broiler chickens. The antioxidant activity present in grape seed extract (GSE) could be a viable alternative to high inclusion levels of vitamin E (VE) as a nutritional strategy to improve the antioxidant capacity of birds and, thus, prevent leg abnormalities. Objective: To evaluate the effect of partial substitution of VE with grape GSE on leg health and performance of broiler chickens. Methods: Four hundred and twenty newly-hatched Ross 308 male broiler chickens were distributed into three treatments: 1) Control-AL, a diet containing 40 IU/kg of VE and fed ad libitum (CAL); 2) Control-FR, the CAL diet but offered through a feed restriction program (CFR); and 3) grape seed extract-AL, a diet containing 10 mg/kg of GSE + 10 IU/kg of VE fed ad libitum (GSE-AL). The trial was conducted for 47 days. Feed intake and body weight of the chickens were recorded weekly to evaluate performance. At day 43, gait score (GS), valgus/varus angulation (AngV), foot burn (FB), and hock burn (HB) lesions were evaluated. At day 47, tibia-breaking strength (TBS) and gastrocnemius tendon-breaking strength (GTBS) were evaluated. Results: Birds in the GSE-AL treatment showed reduced (p=0.05) GS compared to the other treatments. No statistical differences (p>0.05) were found in AngV, HB, FB, TBS, TGBS, and growth performance among treatments. Conclusions: These results suggest that GSE may partially replace VE in broiler diets without negative effects on growth performance or leg health. Further research is required to evaluate the potential of grape seed extract to replace VE or other ingredients with antioxidant activity under different rearing conditions and feeding programs. [ABSTRACT FROM AUTHOR]

Valproic acid (VPA) is a teratogenic antiepileptic drug that, when administered during the early stages of pregnancy, can produce alterations in embryo-fetal development, which manifest both at the level of the nervous system and the testicle. However, it has been reported that the administration of vitamin E (VE) could reverse these alterations. The study aimed to determine the protective effect of VE at the testicular level in fetuses and pubertal mice exposed to VPA during the embryonic phase of their development. 30 pregnant adult female mice (Mus musculus) BALB/c strain were used, which were divided into 6 groups. The study included the analysis of male fetuses at 17.5 days post-coital (dpc) and juvenile males at 6 weeks post-natal. Groups 1 and 4 were administered 0.3 mL of physiological solution. Groups 2 and 5 were given 600 mg/kg of VPA (VPA groups), while groups 3 and 6 were given the same dose of VPA supplemented with 200 IU of VE (VPA+VE). The normal and pathological histology of the peritubular compartment of the testis was described. In the VPA groups, degeneration of the peritubular wall, and atrophy of the seminiferous tubules, as well as exfoliation of the germ cells, were evident. On the contrary, in the VPA+VE groups such signs were not observed and the morphology presented a normal appearance with only some focal alterations. These results corroborate the fact that the administration of VE partially counteracts the deleterious effects caused by VPA. [ABSTRACT FROM AUTHOR]

Background: Nano-vitamins and minerals are used in animal nutrition to improve performance and health of broiler chickens as a potential alternative to antibiotic growth promoters. Objective: To evaluate the effect of several levels of a dietary nano α-tocopherol acetate plus selenium compound (NTS) on growth, intestinal histomorphometry, carcass traits, and immune status of broiler chickens. Methods: A total of 240 one-day-old Ross 308 chickens were randomly divided into four groups, each one with three pens (n=20 per pen). Four doses of nano α-tocopherol acetate and selenium (0, 5, 7, and 10 mg/kg) were included in the basal diet for 42 days. Results: Final body weight, cumulative body weight gain, and final conversion ratio significantly improved with increasing NTS levels (p<0.05). Carcass traits and weight of internal organs increased in the groups fed 7 and 10 mg/kg NTS. High NTS doses significantly increased immune vaccine titers against Newcastle disease, avian influenza virus, infectious bursal disease, and infectious bronchitis. Moreover, dietary addition of NTS improved intestinal morphometry. Conclusion: Thus, NTS (7 and 10 mg/kg) can be added to poultry rations to improve production, carcass characteristics, and immune status of broilers. Further studies are needed to evaluate NTS residues in meat. [ABSTRACT FROM AUTHOR]

O Neuroblastoma (NB) é uma neoplasia do sistema nervoso simpático, e o segundo tumor sólido maligno extracraniano mais comum da infância. Na terapia antineoplásica, complicações orais podem ser observadas, dentre elas a mucosite oral (MO). Trata-se de uma inflamação aguda da mucosa, proveniente da toxicidade dos quimioterápicos. Este relato de caso enfatiza o manejo da MO, bem como sua influência na condição sistêmica e qualidade de vida. Paciente do sexo feminino, nove anos, apresentou recidiva de NB metastático, após tratamento de primeira linha. Admitida na unidade hospitalar para tratamento oncológico na enfermaria de pediatria oncológica, queixando-se de dor intensa em cavidade bucal e orofaringe, associada a pancitopenia severa febril. Ao exame físico apresentava disfagia e déficit ponderal grave, que debilitava a deglutição da própria saliva. O exame intraoral revelou lesões de MO grau 3, segundo a Organização Mundial de Saúde (OMS), em lábios, gengiva anterior e orofaringe. O tratamento consistiu em remoção de debris local, higiene da cavidade bucal com clorexidina 0,12% e utilizando haste flexível de algodão estéril tipo “Swab”, visando controle microbiano local, diariamente. Além disso, foi aplicado no leito eritematoso e hemorrágico fotobiomodulação (660 nm, 50 mW, 2 J/cm2, 90 segundos) pontualmente nas áreas do leito da lesão e em varredura na região de orofaringe (sessões intercaladas). Foi prescrito acetato de racealfatocoferol (vitamina E) para ação antioxidante e hidratação dos lábios. Concomitante a mucosite, a paciente apresentou pancitopenia febril severa, sendo necessário uso de cefepima 150 mg/kg/dia, com coleta prévia de hemoculturas, fator estimulador de colônias de granulócitos, Fluconazol, hidratação e suporte nutricional. As hemoculturas foram negativas. As consequências da mucosite contribuíram para desnutrição e piora da qualidade de vida. Conclui-se que a intervenção odontológica em interdisciplinaridade, possibilitou o restabelecimento físico e emocional, possibilitando melhor uma qualidade de vida da paciente.

Objective: To determine the effectiveness of vitamin E in nonalcoholic fatty liver disease (NAFLD) among type 2 diabetes patients without advanced fibrosis. Materials and methods: A quasi-experimental analytical study consisting of two groups: an experimental one, which received vitamin E 400 IU in addition to the standard treatment, and a control group, which received only the standard treatment. The study included 71 patients in each group. Both groups underwent liver fibrosis scoring, liver ultrasound and glutamate pyruvate transaminase measurement at study baseline and after six months. Moreover, the Wilcoxon test was used to compare the concentrations of fibrosis score and glutamate pyruvate transaminase values within the same group, and the Mann-Whitney U test was used to evaluate the differences between the experimental and control groups. The Wilcoxon test was also used to compare ultrasound severity. Then, a logistic regression analysis was performed. The information was entered into a data collection sheet using Microsoft Excel; afterwards, a database was coded and created using IBM SPSS Statistics statistical software 23.0. Results: Among the results, it was found that vitamin E was significantly effective in reducing liver fibrosis, transaminase and ultrasound severity scores (Z = -4.727 and p < 0.05). According to the logistic regression analysis, glutamate pyruvate transaminase levels and fibrosis score are not substantially explained by the confounding variables included in the model at 95 % confidence. Conclusions: Vitamin E at a dose of 400 IU given orally for six months is an effective intervention to control the progression of liver disease, which can be quantified by fibrosis score, transaminase reduction and ultrasound assessment after a 6-month follow-up. [ABSTRACT FROM AUTHOR]

Antecedentes: se cuenta con recomendaciones de energía y nutrientes para población sana, sin embargo, nutrientes como la vitamina D, E, K se les atribuyen funciones importantes en diferentes situaciones de salud. Objetivo: explorar la efectividad de dosis dietarias y de suplementos de las vitaminas D, E y K en condiciones especiales de salud y enfermedad. Materiales y métodos: se realizó una búsqueda de documentos en las bases de datos Pubmed, Scopus, Sciencedirect, Lilacs, Scielo, Ebsco, y en textos especializados utilizando palabras claves: “vitamin D”, “vitamin E”, “vitamin K”, “health”, “disease”, “nutritional recommendations” Resultados: hay un importante número de estudios y revisiones sistemáticas que contribuyen con la evidencia y la discusión en cuanto efecto, dosis y tiempo las cuales arrojaron tanto desenlaces positivos como nulos Conclusión: los efectos de la vitamina D dietaria en la salud ósea están bien documentados y los suplementos de la misma acompañados de calcio están indicados en grupos poblaciones con riesgo de osteoporosis, pero no en otras condiciones clínicas. No hay suficiente evidencia sobre los beneficios de la vitamina E en el manejo o prevención de enfermedad hepática, cardiovascular o cáncer. La vitamina K podría ser importante en la salud ósea, sobre otras condiciones clínicas.

Objetivo: Determinar la efectividad de la vitamina E en la esteatosis hepática no alcohólica (EHGNA) en pacientes diabéticos tipo 2 sin fibrosis avanzada. Materiales y métodos: Estudio analítico de tipo cuasi experimental. Se formaron dos grupos, un grupo experimental que recibió vitamina E de 400 UI además del manejo convencional, y otro grupo de control con manejo convencional. El estudio incluyó a 71 pacientes en cada grupo. Ambos grupos fueron sometidos al cálculo de un puntaje de fibrosis hepática, ecografía hepática y a la medición de la transaminasa glutámico-pirúvica al inicio del estudio y tras 6 meses. Asimismo, para comparar concentraciones de los valores de puntaje de fibrosis y de la transaminasa glutámico-pirúvica dentro de un mismo grupo se empleó la prueba Wilcoxon, y para evaluar diferencias entre el grupo experimental y control se realizó la prueba de U de Mann-Whitney. Para comparar la severidad ecográfica se empleó la prueba de Wilcoxon. Luego se realizó la regresión logística. Se procedió a registrar la información en una ficha de recolección de datos haciendo uso del programa Microsoft Excel, posteriormente, se procedió a codificar y generar una base de datos con el paquete estadístico SPSS v. 23. Resultados: Dentro de los resultados se halló que la vitamina E fue efectiva en reducir el puntaje fibrosis hepática, transaminasas y severidad ecográfica en forma significativa (Z = -4,727 y p < 0,05). De acuerdo al análisis de regresión lineal el nivel de TGP y de score de fibrosis no son explicados significativamente por las variables confusoras incluidas en el modelo al 95 % de confianza. Conclusiones: La vitamina E a una dosis de 400 UI vía oral durante 6 meses es una intervención efectiva para controlar la progresión de la hepatopatía que puede cuantificarse mediante puntaje de fibrosis, disminución de transaminasas y valoración ecográfica tras 6 meses de seguimiento.

Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introducción: Se ha sugerido que la preeclampsia puede ser prevenida por la ingesta de vitamina E y C, dado el mecanismo fisiopatológico de esta enfermedad. Objetivo: Determinar la eficacia conjunta de la vitamina C y E en la prevención de la preeclamsia. Métodos: Revisión sistemática de ensayos clínicos aleatorizados. Se realizó una búsqueda en las bases de datos pubmed/medline, SCOPUS, Web of Science, Cochrane Library, EMBASE, y Clinical Trials. El riesgo de sesgo de los ensayos clínicos aleatorios se evaluó mediante la herramienta Cochrane versión 2. Se realizó un metanálisis de efectos aleatorios y se calcularon los riesgos relativos, con los correspondientes intervalos de confianza al 95 %. Resultados: Se incluyeron 7 estudios (n= 1 475). No se encontró asociación estadísticamente significativa del tratamiento con suplementación de vitamina C y E con respecto a la preeclampsia (riesgo relativo: 1,03; IC95 %: 0,78-1,26). Conclusiones: La suplementación dual de vitamina C y E no previene la preeclamsia en gestantes con riesgo de padecer la enfermedad.

An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregulation and whether the effects of MSG overdose can be inhibited by vitamin E. MSG at a dose of (4 mg/kg; orally) that exceeds the average human daily consumption by 1000x was administered daily for 7 days to the rats in the model group. Whereas, rats treated with vitamin E were divided into two groups and given daily doses of MSG plus 100 mg/kg vitamin E or MSG plus 300 mg/kg vitamin E. On the eighth day, all rats were culled. Using light and electron microscopy examinations, a profound aortic injury in the model group was observed demonstrated by damaged endothelial layer, degenerated smooth muscle cells (SMC) with vacuoles and condensed nuclei, vacuolated cytoplasm, disrupted plasma membrane, interrupted internal elastic lamina, clumped chromatin, and damaged actin and myosin filaments. Vitamin E significantly protected aorta tissue and cells as well as inhibited MSG-induced tissue malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a). The highest used vitamin E dosage was more effective. Additionally, a significant correlation was observed between the aortic injury degree and tissue MDA, TNF-a, IL-6, and superoxide dismutase (SOD) levels (p=0.001). Vitamin E effectively protects against aortopathy induced by toxic doses of MSG in rats and inhibits oxidative stress and inflammation. [ABSTRACT FROM AUTHOR]

Diabetes mellitus is represented worldwide as a healthcare challenge. Various treatments have been used in an attempt to improve glycemic control and decrease the disease's devastating complications. The present study aimed to assess the effect on diabetes-relevant parameters of the combination therapy with sitagliptin plus metformin in type 2 diabetic patients using adjuvant vitamin E or propolis as add-on therapy. For this purpose, three serum samples were collected from patients; first visit (baseline) and 8-week vitamin E added to their course of therapy, then serum sample collected at second visit followed by a washout period of one week and propolis added to the list of patients' therapy for additional 8-weeks and serum collected at the end of the 8-weeks (third visit). The collected samples were frozen until analysis. The baseline and post-therapy samples were analyzed for fasting blood sugar (FBS), glycated hemoglobin (HBA1c), C-peptide, and insulin; and the results were analyzed statistically. The results confirmed that vitamin E and propolis have both improved measured parameters through significant reduction of FBS and HBA1c together with improved insulin sensitivity through significant reduction of insulin level and C-peptide compared to baseline levels. Moreover, propolis has shown a higher effect over vitamin E shown by its increased positive effects on measured parameters. The study concluded that adjuvant addition of either propolis or vitamin E could improve glycemic control and associated parameters of insulin and relevant C-peptide level. [ABSTRACT FROM AUTHOR]

Background: There are energy and nutrient recommendations for a healthy population; however, important functions in different health situations are attributed to nutrients such as vitamins D, E, K, E and K. Objective: To explore the effectiveness of dietary doses and supplements of vitamins D, E and K in special conditions of health and disease. Materials and Methods: A document search was carried out in the PubMed, Scopus, Sciencedirect, Lilacs, Scielo and Ebsco databases, and in specialized texts using keywords: "vitamin D", "vitamin E", "vitamin K", "Health", "disease", "nutritional recommendations". Results: There is a significant number of studies and systematic reviews that contribute to the evidence and discussion regarding effect, dose and time, which yielded both positive and null outcomes. Conclusion: The effects of dietary vitamin D in bone health are well documented and its supplementation accompanied by calcium is indicated in population groups at risk for osteoporosis, but not in other clinical conditions. There is insufficient evidence on the benefits of vitamin E in the management or prevention of liver disease, cardiovascular disease, or cancer. Vitamin K could be important in bone health, over other clinical conditions. [ABSTRACT FROM AUTHOR]

RESUMO A miopatia nutricional é uma doença degenerativa que pode afetar os músculos esqueléticos e cardíaco, causada pela deficiência dietética de selênio e/ou vitamina E. Objetivou-se relatar a ocorrência de miopatia nutricional em dois potros Puro Sangue Inglês, criados de forma extensiva, com baixa disponibilidade de forragem e sem suplementação mineral. De um lote de nove animais de diferentes idades (cinco éguas adultas, uma potra lactente de três meses,uma mula e dois potros de 16 e 17 meses), apenas os dois últimos foram afetados. Clinicamente, havia decúbito lateral ou esternal, taquicardia, taquipneia, desidratação e dor à palpação muscular na região dos glúteos.O diagnóstico presuntivo de miopatia nutricional foi realizado por meio da associação dos sinais clínicos aos dados epidemiológicos.O animal 1 foi eutanasiado cinco dias após o atendimento devido à piora gradativa do quadro, e o animal 2 recuperou-se com o tratamento adotado. O diagnóstico foi confirmado com base nos exames complementares, nos achados de necropsia e na dosagem da concentração hepática de selênio. Este relato de caso alerta para o risco da ocorrência de miopatia nutricional em equinos, sobretudo jovens, sem acesso a pastagens ou feno de boa qualidade e sem suplementação mineral adequada.

Blood parameters are good indices used in confirming health, physical status of animals and are of ecological significance in understanding the relationships between blood parameters and environment conditions. Thus this study aimed to examine whether feed restriction during pregnancy with or without vitamin E could have any detrimental effect or pose any danger to blood parameters of pregnant rabbits does. A total of Seventy five (75) rabbits consisting of sixty (60) 5 months old rabbit does of different breeds (Chinchilla, Dutch, New Zealand) with initial live weight of 1.7-2.0 kg were randomly allotted into 12 treatments of 5 replicates each during pregnancy period. The rabbit does were subjected to two levels of feed restriction (0% and 15%) at three different periods of gestation (15-19days, 20-24days and 25- 29days) with or without vitamin E inclusion (0 and 300mg/kg). Data obtained on haematological indices were subjected to Analysis of Variance in a completely randomized design. Results obtained showed that Ad libitum feeding with vitamin E inclusion significantly (p<0.05) increased higher mean value for packed cell volume, haemoglobin, white blood cell count and Neutrophils levels of gestating rabbit does than the restricted group, this may be consider as a good indicator of increasing immunity efficiency. It may be concluded that feed restriction and periods of feed restriction with or without E inclusion does not have any detrimental effect on hematological parameters of gestating rabbit does as the values obtained in this study are within the ranges of blood values reported by authors for gestating rabbit does. The results shows that feed restriction did not resulted in levels above the recommended ranges of values reported by authors that have worked on gestating rabbit does. Which shows that feed restriction with or without vitamin E inclusion does not have any negative effect on gestating rabbit does. [ABSTRACT FROM AUTHOR]

Premenopause and menopause are nowadays a matter of public health, due to the increasing life expectancy for wo men. The medical issues related to the period of pre me-no pause and menopause are important, since they can alter the quality of the woman’s life. EstroPlus® is a natural for mu la containing phytoestrogens extracted from soy germs (Glycine hisipida) with 40% isoflavones (45 mg), vi ta min E (25.2 mg) and 30 mg of grapeseed extract (Vitis vi ni fera) with 95% proanthocyanidins. The natural therapy for reducing the symptoms of menopause, aspects regarding the value of the treatment of surgical induced menopause with phytoestrogens, is a preliminary study. EstroPlus® study had a 6-month monitoring period in 2011 and involved four in ves ti ga ting physicians from the Bega Clinical Hospital of Ob ste trics and Gynecology, under the coordination of Prof. D. Anastasiu (MD, PhD). [ABSTRACT FROM AUTHOR]

Antecedentes: actualmente existe un creciente interés en investigar métodos que logren disminuir el dolor muscular de inicio retardado. Se ha postulado que antioxidantes como las vitaminas C y E pueden atenuarlo. Objetivo: evaluar la efectividad de vitamina E en la atenuación del dolor muscular de inicio retardado. Materiales y métodos: se realizó una búsqueda bibliográfica en las bases de datos Medline, Registro Central Cochrane, Scopus, SportDiscus y SciELO, utilizando los términos: “vitamin e supplementation”, “muscle damage” y “delayed onset muscle soreness”. Resultados: se revisaron estudios en diversos grupos poblacionales, con diferentes métodos de evaluación y diversas dosis de vitamina E. Los resultados obtenidos fueron controversiales, en algunos casos se demostró un efecto atenuante del dolor muscular de inicio retardado y en otros casos no. Conclusiones: la vitamina E produce una disminución del estrés oxidativo y estabilización el sarcolema; no obstante, faltan pruebas concluyentes para afirmar que la vitamina E tenga el efecto de generar mejoras en los biomarcadores asociados al dolor muscular de inicio retardado.

O pé diabético acomete de 4 a 10% dos pacientes diabéticos por ano, e apresenta um alto índice de amputação e mortalidade (39-80%). O diabetes mellius (DM) está dentre as doenças crônicas que aumentam a geração das espécies moleculares reativas de oxigênio (EROs) pela oxidação da glicose. O uso de antioxidantes associados a nanocarreadores lipídicos é uma ferramenta promissora no tratamento da cicatrização diabética deficiente. O objetivo dessa mini-review é apresentar o mecanismo fisiopatológico e como a vitamina E atua na prevenção e tratamento da ferida diabética, assim como os nanocarreadores lipídicos sólidos (NLS) associados a vitamina E podem auxiliar acelerando o processo de cicatrização deficiente da ferida diabética.

Woody plants are important source of edible oil, and Camellia hainanica and Camellia sinensis are two new option. The physicochemical properties and fatty acid composition were determined in both species. The oil content of C. hainanica was 37.60–41.60%, and that of C. sinensis was 31.04–33.20%. There were no significant differences in saponification value, refractive index or relative density (P > 0.05). The types of fatty acids were the same in both species, but the composition was significantly different (P < 0.01). Among the nine fatty acids measured, only the concentration of oleic acid was higher in C. hainanica oil than that C. sinensis oil. The contents of vitamin E and total phenols in C. hainanica oil were significantly higher than those in C. sinensis oil (P < 0.01). The higher unsaturated fatty acids, vitamin E, and total phenols, in C. hainanica give it a greater advantage. [ABSTRACT FROM AUTHOR]

Objective: To assess vitamin E intake and its relationship with sociodemographic variables, and to identify the main dietary sources of the nutrient in the diet of adolescents. Methods: This is a population-based cross-sectional study that used data from 891 adolescents living in Campinas, SP, participating in ISACamp 2014/15 (Health Survey) and ISACamp-Nutri 2015/16 (Food Consumption and Nutritional Status Survey). The nutrient intake averages were estimated using the Generalized Linear Model, adjusted for the total energy of the diet. Dietary sources of vitamin E were identified from the calculation of the relative contribution. Results: The average vitamin E intake was 3.2 mg for adolescents aged 10 to 13 years and 3.5 mg for those aged 14 to 19 years, results far below the recommended values of 9 and 12 mg, respectively. The prevalence of inadequacy was 92.5%. Ten foods/ food groups represented 85.7% of vitamin E present in the adolescents’ diet; the vegetable oils group accounted for more than a quarter of the contribution (25.5%), followed by cookies (9.1%) and beans (8.9%). Conclusions: There were a low intake and a high prevalence of inadequate vitamin E intake among adolescents in Campinas, with vegetable oil as the main source. For the total number of adolescents, almost 33% of the nutrient content was derived from foods of poor nutritional quality such as cookies, packaged snacks, and margarine. The results of this study can guide public health actions that aim to improve the quality of adolescents’ diets. [ABSTRACT FROM AUTHOR]

Copyright of Revista Argentina de Antropología Biológica is the property of Revista Argentina de Antropologia Biologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dado que la anemia afecta el normal crecimiento y desarrollo de los niños, la Sociedad Argentina de Pediatría recomienda la suplementación preventiva diaria con sulfato ferroso. Sin embargo, el tratamiento diario puede llevar a la sobrecarga tisular de hierro provocando daño sobre proteínas, lípidos y ADN. Con el propósito de eludir estos efectos no deseados, ha surgido como alternativa la posibilidad de implementar un tratamiento alternativo que consiste en la suplementación semanal. Por otra parte, la vitamina E, es el antioxidante no enzimático liposoluble más importante y esencial en la defensa celular. A raíz de esto, el presente trabajo tiene como objetivo evaluar el efecto de la vitamina E sobre el sulfato ferroso en sus dos formas de administración (semanal y diaria) en linfocitos de sangre periférica humana cultivados in vitro. Se llevó a cabo el ensayo de micronúcleos con bloqueo de la citocinesis, y se realizaron 8 tratamientos que incluyen los respectivos controles y tratamientos combinados de sulfato ferroso diario y semanal con dos dosis de vitamina E. Se evidenciaron diferencias estadísticamente significativas para la frecuencia de micronúcleos (F= 840,04; p= 0,0). Los resultados obtenidos en este trabajo demostraron un efecto protector de la vitamina E, disminuyendo el daño que el sulfato ferroso ocasiona. Sumado a esto, se corroboró que la administración del mismo en dosis únicas semanales provoca menor daño cromosómico que en dosis diarias.

Introduction: Diabetes Mellitus is one of the most common chronic noncommunicable diseases in the world, the fourth or fifth cause of death in most high-income countries. The World Health Organization reported in 2014 a prevalence of 422 million diabetics worldwide. Objective: to assess the effect of vitamin E on endogenous nucleophilic antioxidants in a biomodel of streptozotocin-induced diabetes mellitus. Methods: 40 male Wistar rats were used in four groups of 10 rats each: non-diabetic control, diabetic control, and two diabetic groups that received supplementation with doses of 25 and 50 mg / kg / day of vitamin E, respectively. Serum values of glucose, albumin, uric acid and total bilirubin were determined in all animals at 15-day intervals for one month. The U-tests of Mann-Whitney and Wilcoxon with a significance level of 5% were used to compare the central values of the biochemical variables between the groups of rats. Results: with vitamin E supplementation in diabetic rats, no variation of serum albumin was found (median in g / L 36,70 and 36,40), while uric acid (median in mmol / L 76, 50 and 187.5) and BT (median in mmol / L 2.90 and 5.00) decreased significantly, regardless of the antioxidant dose. The reduction of uric acid was faster and at a lower dose than BT. Conclusions: supplementation with vitamin E in the experimental model of diabetes mellitus, reduces serum levels of nucleophilic antioxidants, which at high concentrations represent a risk of morbid processes associated with tissue damage.

Introduction: Background: the clinicians rarely have to cope with diseases of nutritional origin and scarcely, although possible, vitamins alterations produce neurological symptoms. Objectives: to show, based on two clinical cases, the neurological symptoms due to liposoluble vitamins alterations, focusing on vitamins E and A. Conclusions: it is important to consider liposoluble vitamin alterations as a cause of neurological symptoms, despite their rarity, after rolling out the most probable entities. [ABSTRACT FROM AUTHOR]

Background: Carcass and sheep meat quality are influenced by several factors, such as race, age, slaughter weight, type of diet, and dietary supplementation. Objective: To evaluate the effect of castration and vitamin E supplementation on performance, carcass characteristics and meat of lambs slaughtered at 45 kg. Methods: Thirty-two male lambs (16 castrated and 16 not castrated) were fed diets with or without the inclusion of vitamin E. The animals had an average age of 180 ± 20 days and a mean weight of 25.1 ± 4.6 kg. Performance was evaluated for 56 days, and the animals were slaughtered when reaching a weight of 45 kg. The experimental design was randomized blocks based on initial weights, and variables were assessed by a 2x2 factorial design (castrated and intact, supplemented or not with vitamin E, with a probability of 5%). Results: Higher proportion (p<0.05) of visceral fat was found in castrated animals (kidney: 2.45%, inguinal: 0.57% and omental: 4.96%) than in intact animals (kidney: 1.25%, inguinal 0.27%. and omental 3.12%). The aged meat samples showed no color differences for any of the treatments, but there were differences in shear force for steaks aged for 7 days, where the castrated animals showed an average of 2.64 kgf and intact animals showed an average 3.29 kgf. The animals supplemented with vitamin E had lower shear forces in non-aged samples. Conclusion: Castration increased deposition of visceral and fat coverage but did not influence the cut yields and total carcass yield. The animals supplemented with vitamin E had lower shear forces in non-aged samples. [ABSTRACT FROM AUTHOR]

This experiment was designed to study the administration of normal doses of one of recent antimalarial drug and coadministration of vitamin E on the kidney tissue. A total twenty-four adult male albino rats were used and divided into four groups: the first one served as a control, the second received artemether orally for three days consecutively. The rats of the third and fourth groups received the same dose of artemether concomitantly with 50 and 100 mg/kg vitamin E orally daily for 2 weeks. After the last dose, the rats were sacrificed and the kidney tissues with blood samples obtained and processed for light, electron microscopic and biochemical analysis. Histologically, artemether treated kidneys showed atrophied glomeruli with widened urinary space and kidney tubules were degenerated with disturbed contour and some vacuoles inside it. Ultrastructurally, the glomeruli of this group showed hypertrophic endothelial cells, irregularity of its basement membrane, disrupted foot processes and filtration slits. The kidney tubule cells showed loss of basal infoldings, cytoplasmic vacuolation, polymorphic damaged swollen mitochondria a loss of its microvilli towards its capillary lumen. Artemether plus vitamin E of the rat kidney groups showed improvement of morphological changes compared to the changes seen in artemether alone. These data were confirmed by biochemical findings with marked improvement of blood urea and creatinine levels and increase of anti-oxidant enzyme activities of glutathione peroxidase and superoxide dismutase in the vitamin E treated groups. The results of this study revealed that vitamins E can improve the adverse changes of artemether of rat renal tissue. [ABSTRACT FROM AUTHOR]

This experiment was designed to study the effects of oral administration of artemether which is the most rapid-acting class of antimalarial drugs and the possible protective effect of vitamin E taken with it on the liver of albino rats. A total of twenty-four adult male albino rats were used in this study and were divided into four groups. Group one served as a control and rats in group two exposed to oral intake of artemether daily for fifteen days. The third and fourth groups treated with artemether plus low and high doses of vitamin E respectively. At the end of the experiment, the rats were sacrificed, and the livers were obtained and processed for histological, biochemical and statistical studies. Histological study of the hepatocytes of rats exposed to artemether showed nearly complete disintegration of most cellular contents except few numbers of mitochondria and rough endoplasmic reticulum. Also, the cytoplasm of these cells had few lysosomes, many vacuoles and irregular nuclei with abnormal distribution of chromatin and were shown. The hepatic sinusoids were dilated and filled with blood and vacuoles and bile ductules were abnormal in its structure. Treatment with low and high doses of vitamin E in concomitant with artemether ameliorated the hepatic histopathological lesions and its parenchyma attained nearly normal structure. As far as biochemical changes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rats treated with artemether were significantly elevated as compared to the control. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were significantly increased in the liver in rats treated with artemether. However, vitamin E ameliorated the rise in ALT and AST with decreased MDA concentration and levels of SOD as compared to the corresponding artemether group values. Results of the present suggest that artemether has a harmful and stressful effect on hepatic tissue and the treatment with vitamin E may alleviate this toxicity. [ABSTRACT FROM AUTHOR]

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Sinopsis: Objetivo: Poco se conoce sobre la eficacia de productos para la prevención de radiodermatitis, que afecta al 90–95% de las mujeres con cáncer de mama. El uso de antioxidantes es promisorio, sin embargo, poco estudiado. Los autores desarrollaron un protocolo de ensayo clínico para evaluar el efecto potencial de la aplicación de crema con nanopartículas con vitamina E para prevenir radiodermatitis aguda en mujeres con cáncer de mama. Método: El protocolo sugiere que 108 mujeres adultas con cáncer de mama, que estén recibiendo radioterapia, sean incluidas en este ensayo clínico, controlado, aleatorizado y triple ciego, en un hospital oncológico. Se prevé la distribución de pacientes en tres grupos de 36 personas: el grupo A recibirá una crema con nanopartículas lipídicas con vitamina E, el grupo B obtendrá una crema sin nanopartículas ni vitamina E, y el grupo C usará una crema con nanopartículas sin vitamina E. Los resultados primarios evaluarán la incidencia, el grado y el tiempo de surgimiento de la radiodermatitis. Los resultados secundarios se centrarán en la calidad de vida, los síntomas y la temperatura local. Las pacientes serán evaluadas tres veces por semana, desde el inicio de la radioterapia hasta dos semanas después de la última sesión. El presente proyecto fue aprobado por el comité de ética en investigación de las instituciones involucradas. Objective: Little is known about the efficacy of products that aim to prevent radiodermatitis, which affects between 90–95% of women with breast cancer. The use of antioxidants is promising, however, there is a lack of evidence on their effectiveness. Here, the authors present a clinical trial protocol to evaluate the potential effects of applying a nanoparticle cream with vitamin E to prevent radiodermatitis in patients with breast cancer. Method: The protocol recommends that 108 women with breast cancer, who are receiving radiotherapy, be included in a triple-blinded, randomised, controlled study in an oncology hospital. Patients will be divided in three groups of 36 people each: group A will receive a cream with lipid nanoparticles and vitamin E, group B will obtain a cream without nanoparticles or vitamin E, and group C will receive a cream with nanoparticles without vitamin E. The primary endpoints will evaluate the incidence, degree and time of onset of radiodermatitis. The secondary endpoints will focus on quality of life, symptoms and local temperature. Patients will be assessed three times a week, from the start of their radiotherapy treatment to two weeks after the last session. This protocol was approved by the research ethics committee of the institutions involved. [ABSTRACT FROM AUTHOR]

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Copyright of Revista Brasileira de Reprodução Animal is the property of Revista Brasileira de Reproducao Animal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introducción y objetivos: la terapia con vitaminas C y E ha sido propuesta como adyuvante a la terapia triple estándar (TTE) con el fin de incrementar la tasa de erradicación del Helicobacter pylori (H. pylori). En este estudio probamos esta hipótesis en una cohorte de pacientes de la Amazonía peruana. Materiales y métodos: retrospectivamente, evaluamos una cohorte de 50 pacientes infectados con H. pylori del Hospital de Tarapoto en el período comprendido entre julio-diciembre de 2016; de estos, 25 fueron tratados con TTE (amoxicilina 1 g, claritromicina 500 mg y omeprazol 20 mg, dos veces al día por 14 días) en adyuvancia con las vitaminas C y E, y 25 fueron tomados al azar (1:1), quienes solo recibieron TTE. Se estimó y comparó la efectividad de ambos tratamientos utilizando un modelo regresión general lineal con familia Poisson y link log, teniendo como desenlace de interés la erradicación del H. pylori confirmada por histopatología. Resultados: al comparar la cohorte de expuestos y con los no expuestos, no se encontraron diferencias significativas en sus características basales, incluyendo edad (38 ± 11 frente a 36 ± 10 años), género masculino (65 % frente a 63 %), síntomas y diagnóstico histopatológico. Al comparar la efectividad de ambos tratamientos, se encontró un incrementó no significativo en las tasas de erradicación del 9,5 % (91 % frente a 82 %, razón de tasas de incidencia = 1,11; intervalo de confianza [IC] 95 %: 0,92 a 1,36). Conclusiones: la terapia adyuvante con vitaminas C y E podría ayudar a incrementar la efectividad de la TTE para H. pylori en pacientes de la Amazonía peruana, aunque se requiere confirmar esta hipótesis en un ensayo clínico.

Food additives and flavour enhancers used in the food industry are potential health risks. We tested the hypothesis that the food additive and flavour enhancer, monosodium glutamate (MSG), which is the sodium salt of glutamic acid can induce ultrastructural alterations to the kidney, and the antioxidant vitamin E can protect against acute kidney injuries induced by a toxic dose of MSG in a rat model of the disease. The model group of rats received a daily dose of MSG (4 gm/kg) for 7 days, whereas the protective groups were either received a 100 mg/kg vitamin E plus MSG or 300 mg/kg vitamin E plus MSG for 7 days. Rats were then sacrificed on day 8. Transmission and light microscopy images revealed substantial kidney damage induced by MSG in the model group as demonstrated by degenerated epithelial cells with Pyknotic nuclei, swollen mitochondria, damaged brush margins, dilated tubules, and widening of Bowman's space with shrinkage and deformity of some glomeruli. Treatment of the model group with vitamin E showed a substantial protection of kidney tissue and renal ultrastructure by 300 mg/kg vitamin E compared to a partial protection by 100 mg/kg vitamin E. In addition, MSG significantly (p<0.05) increased serum levels of urea and creatinine, which were significantly (p<0.05) decreased with vitamin E. However, for serum creatinine, high doses of vitamin E (300 mg/kg) were more effective than lower doses (100 mg/kg) of vitamin E. These results indicate that vitamin E at 300 mg/kg effectively protects against MSG-induced acute kidney injury in rats. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: Adjuvant therapy with vitamins C and E has been proposed to increase standard triple therapy's Helicobacter pylori eradication rate. This study tested this hypothesis in a cohort of patients from the Peruvian Amazon. Material and Methods: We retrospectively evaluated a cohort of 50 patients at Tarapoto Hospital who were treated for H. pylori infections from July to December 2016. Of these, 25 were randomly selected to receive standard triple therapy of 1 g amoxicillin, 500mg clarithromycin and 20mg omeprazole twice a day for 14 days plus adjuvant vitamins C and E. The other 25 only received standard triple therapy. The effectiveness of both treatments was estimated and compared using a general linear regression model using the Poisson family of distributions and log link with H. pylori eradication confirmed by histopathology as the outcome of interest. Results: A comparison of the two groups found no significant differences in their baseline symptoms, histopathological diagnoses, ages (38 ± 11 years vs. 36 ± 10 years) or genders (65%> male vs. 63%> male). A comparison of the effectiveness both treatments found a non-significant increase in eradication rates of 9.5%> (91%> vs. 82%, incidence rate ratio = 1.11; 95%> confidence interval: 0.92 to 1.36). Conclusions: Adjuvant therapy with vitamins C and E may help increase the effectiveness of standard triple therapy for H. pylori in patients in the Peruvian Amazon, although this hypothesis needs to be confirmed in a clinical trial. [ABSTRACT FROM AUTHOR]

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ABSTRACT Azuki beans are small red grains rich in several essential nutrients used in traditional dishes in Asia that, nowadays present many applications around the world. This work aimed at evaluating angularis and niponensis cultivars from south region of Brazil. Both cultivars presented proximal composition similar to literature and the majority fatty acids were 18:2n-6, 16:0 and 18:3n-3. All samples showed polyunsatured fatty acids prevalence and nutritional indices and ratios considered adequate for biological system maintenance of a healthy organism. The grains presented significant contents of tocopherols and vitamin E activity, resulting in a high contribution to the dietary reference intake. Significant contents of iron, manganese and zinc were also found in the azuki beans, and they are very important mainly due to their function as cofactors in metabolic reactions. Phenolic compounds and flavonoids corroborated with other studies and contributed to the antioxidant activity. The principal components multivariate analysis allowed distinguishing the cultivars, and the two principal components could explain 92.28% of data variance.

O objetivo deste estudo foi avaliar o uso de minerais traços (cobre, zinco, selênio e manganês) e vitaminas A e E, na forma injetável, sobre a produção e composição do leite de vacas holandesas no final do período de transição até os 60 dias de lactação. Foram utilizadas 31 fêmeas holandesas divididas em dois grupos experimentais: grupo tratado (n=15) que recebeu suplementação de minerais (10 mg de cobre, 40 mg de zinco, 5 mg de selênio e 10 mg de manganês) e de vitaminas (175 mg de vitamina A e 250 mg de vitamina E) injetável (5 mL da solução dos microminerais e 5 mL das vitaminas pela via subcutânea) aos 225 dias de gestação, aos 255 dias de gestação e no dia do parto; e o grupo controle (n=16), que recebeu injeções de solução fisiológica (na dose de 5 mL pela via subcutânea) nos mesmos dias do grupo tratado. Amostras de leite foram coletadas nos dias sete, 14 e 21 após o parto, onde avaliou-se a produção, a qualidade (colostro), e a composição (gordura, lactose, proteína, extrato seco desengordurado, sólidos totais, ureia e contagem de células somáticas (CCS)) do leite. Os valores iniciais e valores mínimos estimados pelo modelo não indicaram diferença na produção de leite e na CCS entre os grupos. Para o restante dos componentes do leite, somente a ureia apresentou diferença significativa entre os grupos tratados e não tratados (p= 0,002). Também não foi verificada diferença significativa para qualidade de colostro. Portanto, conclui-se que o uso de solução injetável contendo Cu, Zn, Se, Mn e vitaminas A e E tem efeito sobre a composição da ureia do leite, porém não se observou efeito sobre CCS e os demais componentes do leite e na sua produção, porém mais estudos devem ser realizados.

Introducción: la diabetes mellitus es una entidad clínica resultado de la secreción deficiente de insulina que puede ser absoluta o relativa. El marcador bioquímico de la entidad es la hiperglucemia y es la causa de los síntomas característicos de su mal control. La hiperglucemia produce neuropatías, nefropatías, microangiopatía y macroangiopatía. Objetivo: describir el comportamiento de la vitamina E y antioxidantes endógenos en el estrés oxidativo por hiperglucemia crónica en el curso de la diabetes mellitus y las características de estos como antioxidantes. Conclusiones: el conocimiento actualizado de las acciones vitamínicas y otros marcadores debidamente utilizados, son determinantes en la terapéutica o como marcadores de estrés en dicha entidad y contribuyen a la preparación del personal de salud en la calidad de la asistencia médica a los pacientes diagnosticados de una enfermedad crónica prevenible.

In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases.

We sought to investigate the potential protective effect of Vitamin E supplementation against hepatocyte ultrastructural alterations induced by high fat diet (HFD) in a rat model of pre-diabetes. Therefore, rats were either fed with HFD (model group) or a standard laboratory chow (control group) for 12 weeks before being sacrificed. The protective group fed on a HFD and started the treatment with vitamin E (100 mg/kg/day, i.p) from day 1 until being sacrificed at week 12. The harvested liver tissues were examined using transmission electron microscopy (TEM) and blood samples were assayed for biomarkers of liver injury and prediabetes. TEM images showed that HFD induced profound pathological changes to the hepatocyte ultrastructure as demonstrated by degenerated hepatocytes with damaged cytoplasm that have mitochondrial swelling, dilation of endoplasmic reticulum, blebbing of plasma membranes, and cytoplasmic accumulations of lipid droplets and vacuoles, which were substantially but not completely protected with vitamin E. In addition, HFD significantly (p<0.05) augmented biomarkers of liver injury and pre-diabetes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-a), malondialdehyde (MDA), total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C), which were significantly (p<0.05) reduced with vitamin E except TNF-a and TC. Furthermore, none of these biomarkers were reduced to the control level by vitamin E. We conclude that vitamin E is a partial protective agent against HFD-induced liver injury and pre-diabetes. [ABSTRACT FROM AUTHOR]

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The aim of this study was to carry out a comparative analysis of physical and chemical traits of bunches from genotypes of Elaeis oleifera and their interspecific hybrids OxG with Elaeis guineensis, establishing values in bunch components and oil potential, as well as oil quality by analyzing fatty acids, vitamin E and carotenes content. Bunches stemmed from inflorescences without assisted pollination and perimeter presence of E. guineensis. The experimental design used, was a completely randomized experimental design with three experimental units, each comprised of three bunches. E. oleifera Sinú genotype (76.53 %) and OxG hybrid II (72.64 %) obtained the highest fruit set. Regarding oil extraction potential, values were higher in OxG hybrids, finding in hybrid II an outstanding value (20.82%). E. oleifera materials showed better fatty acids profiles with the Sinú genotype being the most prominent material with 79.1 % of unsaturated fatty acids, together with hybrid II (70.2 %). Regarding vitamin E content, we confirmed that E. oleifera possesses high quality oil especially for genotype Coarí (1,006.7 ppm) and hybrid II (1,549.6 ppm); furthermore, genotype Sinú was the one with the highest total carotene content (1,524.7 ppm). [ABSTRACT FROM AUTHOR]

A number of studies has shown that antioxidants, fatty acids and trace minerals may modulate different immune cell activities, and that their deficiency may be associated with diseases and impaired immune responses. In innate immunity, natural killer (NK) cells have a central role, killing virally infected and cancerous cells, and also secreting cytokines that shape adaptive immune responses. Thus, the aim of this study was to evaluate the effect of enriched diets in selenium plus vitamin E and/or canola oil on complete blood count and on NK cell cytotoxicity from blood lymphocytes of Nellore bulls. Bulls that received selenium plus vitamin E had (P=0.0091) higher NK cell cytotoxicity than control bulls. This result positively correlated with serum selenium levels. To the best of our knowledge, this is the first study that showed immunostimulatory effects of selenium plus vitamin E on NK cell cytotoxicity of Nellore bulls.