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2 results on '"vascular cell adhesion-1"'

1. Inhibitory Effect of Indigo Naturalis on Tumor Necrosis Factor-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Umbilical Vein Endothelial Cells

Author

Hsin-Ning Chang, Jong-Hwei Su Pang, Sien-Hung Yang, Chi-Feng Hung, Chi-Hsin Chiang, Yin-Ku Lin, and Tung-Yi Lin

Subjects
psoriasis, indigo naturalis, human umbilical vein endothelial cell, vascular cell adhesion-1, c-Jun, Organic chemistry, QD241-441
Abstract

The use of indigo naturalis to treat psoriasis has proved effective in our previous clinical studies. The present study was designed to examine the anti-inflammatory effect of indigo naturalis in primary cultured human umbilical vein endothelial cells (HUVECs). Pretreatment of cells with indigo naturalis extract attenuated TNF-α-induced increase in Jurkat T cell adhesion to HUVECs as well as decreased the protein and messenger (m)RNA expression levels of vascular cell adhesion molecule-1 (VCAM-1) on HUVECs. Indigo naturalis extract also inhibited the protein expression of activator protein-1 (AP-1)/c-Jun, a critical transcription factor for the activation of VCAM-1 gene expression. Since the reduction of lymphocyte adhesion to vascular cells by indigo naturalis extract could subsequently reduce the inflammatory reactions caused by lymphocyte infiltration in the epidermal layer and help to improve psoriasis, this study provides a potential mechanism for the anti-inflammatory therapeutic effect of indigo naturalis extract in psoriasis.

Published
2010
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2. Inhibitory effect of indigo naturalis on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells

Author

Jong-Hwei S. Pang, Chi-Feng Hung, Yin-Ku Lin, Chi-Hsin Chiang, Sien-Hung Yang, Tung-Yi Lin, and Hsin-Ning Chang

Subjects
medicine.medical_specialty, Umbilical Veins, Lymphocyte, indigo naturalis, Pharmaceutical Science, Vascular Cell Adhesion Molecule-1, Biology, Jurkat cells, Indigo, Umbilical vein, Article, Analytical Chemistry, lcsh:QD241-441, Jurkat Cells, lcsh:Organic chemistry, Internal medicine, psoriasis, human umbilical vein endothelial cell, vascular cell adhesion-1, c-Jun, Drug Discovery, medicine, Cell Adhesion, Humans, RNA, Messenger, Physical and Theoretical Chemistry, Cell adhesion, Inflammation, Plants, Medicinal, Cell adhesion molecule, Plant Extracts, Tumor Necrosis Factor-alpha, Organic Chemistry, Endothelial Cells, Molecular biology, Transcription Factor AP-1, Endocrinology, medicine.anatomical_structure, Chemistry (miscellaneous), Cell culture, Molecular Medicine, Human umbilical vein endothelial cell
Abstract

The use of indigo naturalis to treat psoriasis has proved effective in our previous clinical studies. The present study was designed to examine the anti-inflammatory effect of indigo naturalis in primary cultured human umbilical vein endothelial cells (HUVECs). Pretreatment of cells with indigo naturalis extract attenuated TNF-α-induced increase in Jurkat T cell adhesion to HUVECs as well as decreased the protein and messenger (m)RNA expression levels of vascular cell adhesion molecule-1 (VCAM-1) on HUVECs. Indigo naturalis extract also inhibited the protein expression of activator protein-1 (AP-1)/c-Jun, a critical transcription factor for the activation of VCAM-1 gene expression. Since the reduction of lymphocyte adhesion to vascular cells by indigo naturalis extract could subsequently reduce the inflammatory reactions caused by lymphocyte infiltration in the epidermal layer and help to improve psoriasis, this study provides a potential mechanism for the anti-inflammatory therapeutic effect of indigo naturalis extract in psoriasis.

Published
2010

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