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29. Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders

Author

Dreyer, Henriette H. M., primary, van Tuyll van Serooskerken, Eleonora Sofie, additional, Rodenburg, Lisa W., additional, Bittermann, Arnold J. N., additional, Arets, Hubertus G. M., additional, Reuling, Ellen M. B. P., additional, Verweij, Johannes W., additional, Haarman, Eric G., additional, van der Zee, David C., additional, Tytgat, Stefaan H. A. J., additional, van der Ent, Cornelis K., additional, Beekman, Jeffrey M., additional, Amatngalim, Gimano D., additional, and Lindeboom, Maud Y. A., additional

Published
2023
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33. Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders

Author

Dreyer, Henriette H. M., van Tuyll van Serooskerken, Eleonora Sofie, Rodenburg, Lisa W., Bittermann, Arnold J. N., Arets, Hubertus G. M., Reuling, Ellen M. B. P., Verweij, Johannes W., Haarman, Eric G., van der Zee, David C., Tytgat, Stefaan H. A. J., van der Ent, Cornelis K., Beekman, Jeffrey M., Amatngalim, Gimano D., and Lindeboom, Maud Y. A.

Abstract

Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory tract disorders are in part caused by alterations in airway epithelial cell functions such as the activity of motile cilia. This can be studied using airway epithelial cell culture models of patients with EA. Therefore, the aim of this study was to evaluate the feasibility to culture and functionally characterize motile cilia function in the differentiated air–liquid interface cultured airway epithelial cells and 3D organoids derived from nasal brushings and bronchoalveolar lavage (BAL) fluid from children with EA. We demonstrate the feasibility of culturing differentiated airway epithelia and organoids of nasal brushings and BAL fluid of children with EA, which display normal motile cilia function. EA patient-derived airway epithelial cultures can be further used to examine whether alterations in epithelial functions contribute to respiratory disorders in EA.

Published
2023
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35. Graft dilatation and Barrett's esophagus in adults after gastric pull-up and jejunal interposition for long-gap esophageal atresia

Author

Zorgeenheid Kinderchirurgie Medisch, MS MDL 1, Cancer, Pathologie Pathologen staf, Child Health, Longziekten patientenzorg, MS KNO, Brain, van Tuyll van Serooskerken, Eleonora Sofie, Gallo, Gabriele, Weusten, Bas L, Westerhof, Jessie, Brosens, Lodewijk Aa, Zwaveling, Sander, Ruiterkamp, Jetske, Hulscher, Jan Bf, Arets, Hubertus Gm, Bittermann, Arnold Jn, van der Zee, David C, Tytgat, Stefaan Haj, Lindeboom, Maud Ya, Zorgeenheid Kinderchirurgie Medisch, MS MDL 1, Cancer, Pathologie Pathologen staf, Child Health, Longziekten patientenzorg, MS KNO, Brain, van Tuyll van Serooskerken, Eleonora Sofie, Gallo, Gabriele, Weusten, Bas L, Westerhof, Jessie, Brosens, Lodewijk Aa, Zwaveling, Sander, Ruiterkamp, Jetske, Hulscher, Jan Bf, Arets, Hubertus Gm, Bittermann, Arnold Jn, van der Zee, David C, Tytgat, Stefaan Haj, and Lindeboom, Maud Ya

Published
2023

36. Bacterial Colonization of the Lower Airways in Children With Esophageal Atresia

Author

Zorgeenheid Kinderchirurgie Medisch, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Longziekten patientenzorg, MS KNO, Brain, van Tuyll van Serooskerken, Eleonora Sofie, Duhoky, Rauand, Verweij, Johannes W, Bont, Louis, Arets, Hubertus G M, Bittermann, Arnold J N, van der Zee, David C, Tytgat, Stefaan H A J, Lindeboom, Maud Y A, Zorgeenheid Kinderchirurgie Medisch, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Longziekten patientenzorg, MS KNO, Brain, van Tuyll van Serooskerken, Eleonora Sofie, Duhoky, Rauand, Verweij, Johannes W, Bont, Louis, Arets, Hubertus G M, Bittermann, Arnold J N, van der Zee, David C, Tytgat, Stefaan H A J, and Lindeboom, Maud Y A

Published
2023

37. Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders

Author

Longziekten onderzoek 2, MS KNO, Brain, Longziekten patientenzorg, Child Health, Zorgeenheid Kinderchirurgie Medisch, Speerpunt Child Health, Infection & Immunity, Onderzoek, Regenerative Medicine and Stem Cells, Dreyer, Henriette H.M., van Tuyll van Serooskerken, Eleonora Sofie, Rodenburg, Lisa W., Bittermann, Arnold J.N., Arets, Hubertus G.M., Reuling, Ellen M.B.P., Verweij, Johannes W., Haarman, Eric G., van der Zee, David C., Tytgat, Stefaan H.A.J., van der Ent, Cornelis K., Beekman, Jeffrey M., Amatngalim, Gimano D., Lindeboom, Maud Y.A., Longziekten onderzoek 2, MS KNO, Brain, Longziekten patientenzorg, Child Health, Zorgeenheid Kinderchirurgie Medisch, Speerpunt Child Health, Infection & Immunity, Onderzoek, Regenerative Medicine and Stem Cells, Dreyer, Henriette H.M., van Tuyll van Serooskerken, Eleonora Sofie, Rodenburg, Lisa W., Bittermann, Arnold J.N., Arets, Hubertus G.M., Reuling, Ellen M.B.P., Verweij, Johannes W., Haarman, Eric G., van der Zee, David C., Tytgat, Stefaan H.A.J., van der Ent, Cornelis K., Beekman, Jeffrey M., Amatngalim, Gimano D., and Lindeboom, Maud Y.A.

Published
2023

41. Choledochal Malformation in Children: Lessons Learned from a Dutch National Study

Author

van den Eijnden, Maria. H. A., de Kleine, Ruben H. J., de Blaauw, Ivo, Peeters, Paul G. J. M., Koot, Bart P. G., Oomen, Matthijs W. N., Sloots, Cornelius E. J., van Gemert, W. G., van der Zee, David C., van Heurn, L. W. E., Verkade, Henkjan J., Wilde, Jim C. H., Hulscher, Jan B. F., and Nederlandse Studiegroep voor Choledochus Cysten/malformaties (NeSCHoC)

Published
2017
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