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15 results on '"van der Zaag, E.S."'

1. Outcomes of surgical treatment of non-metastatic gastric cancer in patients aged 70 and older: A systematic review and meta-analysis

Author

Argillander, T.E., primary, Festen, S., additional, van der Zaag-Loonen, H.J., additional, de Graeff, P., additional, van der Zaag, E.S., additional, van Leeuwen, B.L., additional, Nagengast, W.B., additional, Verhage, R.J.J., additional, Ruurda, J.P., additional, van Munster, B.C., additional, and van Duijvendijk, P., additional

Published
2022
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4. Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

Author

Detering, Robin, primary, Karthaus, Eleonora G., additional, Borstlap, Wernard A.A., additional, Marijnen, Corrie A.M., additional, van de Velde, Cornelis J.H., additional, Bemelman, Willem A., additional, Beets, Geerard L., additional, Tanis, Pieter J., additional, Aalbers, Arend G.J., additional, Aalbers, A.G.J., additional, Acherman, Y., additional, Algie, G.D., additional, Alting von Geusau, B., additional, Amelung, F., additional, Aukema, T.S., additional, Bakker, I.S., additional, Bartels, S.A., additional, Basha, S., additional, Bastiaansen, A.J.N.M., additional, Belgers, E., additional, Bleeker, W., additional, Blok, J., additional, Bosker, R.J.I., additional, Bosmans, J.W., additional, Boute, M.C., additional, Bouvy, N.D., additional, Bouwman, H., additional, Brandt-Kerkhof, A., additional, Brinkman, D.J., additional, Bruin, S., additional, Bruns, E.R.J., additional, Burbach, J.P.M., additional, Burger, J.W.A., additional, Buskens, C.J., additional, Clermonts, S., additional, Coene, P.P.L.O., additional, Compaan, C., additional, Consten, E.C.J., additional, Darbyshire, T., additional, de Mik, S.M.L., additional, de Graaf, E.J.R., additional, de Groot, I., additional, tot Nederveen Cappel, RJ de Vos, additional, de Wilt, J.H.W., additional, van der Wolde, J., additional, Boer, FC den, additional, Dekker, J.W.T., additional, Demirkiran, A., additional, Derkx-Hendriksen, M., additional, Dijkstra, F.R., additional, van Duijvendijk, P., additional, Dunker, M.S., additional, Eijsbouts, Q.E., additional, Fabry, H., additional, Ferenschild, F., additional, Foppen, J.W., additional, Furnee, E.J.B., additional, Gerhards, M.F., additional, Gerven, P., additional, Gooszen, J.A.H., additional, Govaert, J.A., additional, Van Grevenstein, W.M.U., additional, Haen, R., additional, Harlaar, J.J., additional, van der Harst, E., additional, Havenga, K., additional, Heemskerk, J., additional, Heeren, J.F., additional, Heijnen, B., additional, Heres, P., additional, Hoff, C., additional, Hogendoorn, W., additional, Hoogland, P., additional, Huijbers, A., additional, Janssen, P., additional, Jongen, A.C., additional, Jonker, F.H., additional, Karthaus, E.G., additional, Keijzer, A., additional, Ketel, J.M.A., additional, Klaase, J., additional, Kloppenberg, F.W.H., additional, Kool, M.E., additional, Kortekaas, R., additional, Kruyt, P.M., additional, Kuiper, J.T., additional, Lamme, B., additional, Lange, J.F., additional, Lettinga, T., additional, Lips, D.J., additional, Logeman, F., additional, Lutke Holzik, M.F., additional, Madsen, E., additional, Mamound, A., additional, Marres, C.C., additional, Masselink, I., additional, Meerdink, M., additional, Menon, A.G., additional, Mieog, J.S., additional, Mierlo, D., additional, Musters, G.D., additional, Nieuwenhuijzen, G.A.P., additional, Neijenhuis, P.A., additional, Nonner, J., additional, Oostdijk, M., additional, Oosterling, S.J., additional, Paul, P.M.P., additional, Peeters, K.C.M.J., additional, Pereboom, I.T.A., additional, Polat, F., additional, Poortman, P., additional, Raber, M., additional, Reiber, B.M.M., additional, Renger, R.J., additional, van Rossem, C.C., additional, Rutten, H.J., additional, Rutten, A., additional, Schaapman, R., additional, Scheer, M., additional, Schoonderwoerd, L., additional, Schouten, N., additional, Schreuder, A.M., additional, Schreurs, W.H., additional, Simkens, G.A., additional, Slooter, G.D., additional, Sluijmer, H.C.E., additional, Smakman, N., additional, Smeenk, R., additional, Snijders, H.S., additional, Sonneveld, D.J.A., additional, Spaansen, B., additional, Bilgen, EJ Spillenaar, additional, Steller, E., additional, Steup, W.H., additional, Steur, C., additional, Stortelder, E., additional, Straatman, J., additional, Swank, H.A., additional, Sietses, C., additional, Groen, H.A., additional, Hoeve, HG ten, additional, Riele, WW ter, additional, Thorensen, I.M., additional, Tip-Pluijm, B., additional, Toorenvliet, B.R., additional, Tseng, L., additional, Tuynman, J.B., additional, van Bastelaar, J., additional, van Beek, S.C., additional, van de Ven, A.W.H., additional, van de Weijer, M.A.J., additional, van den Berg, C., additional, van den Bosch, I., additional, van der Bilt, J.D.W., additional, van der Hagen, S.J., additional, van der Hul, R., additional, van der Schelling, G., additional, van der Spek, A., additional, van der Wielen, N., additional, van Duyn, E., additional, van Eekelen, C., additional, van Essen, J.A., additional, van Gangelt, K., additional, van Geloven, A.A.W., additional, van Kessel, C., additional, van Loon, Y.T., additional, van Rijswijk, A., additional, van Rooijen, S.J., additional, van Sprundel, T., additional, van Steensel, L., additional, van Tets, W.F., additional, van Westreenen, H.L., additional, Veltkamp, S., additional, Verhaak, T., additional, Verheijen, P.M., additional, Versluis-Ossenwaarde, L., additional, Vijfhuize, S., additional, Vles, W.J., additional, Voeten, S.C., additional, Vogelaar, F.J., additional, Vrijland, W.W., additional, Westerduin, E., additional, Westerterp, M.E., additional, Wetzel, M., additional, Wevers, K.P., additional, Wiering, B., additional, Witjes, C.D.M., additional, Wouters, M.W., additional, Yauw, S.T.K., additional, van der Zaag, E.S., additional, Zeestraten, E.C., additional, Zimmerman, D.D.E., additional, and Zwieten, T., additional

Published
2019
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7. Surgery for colorectal cancer: improving staging by the sentinel lymph node procedure

Author

van der Zaag, E.S., Bemelman, W.A., Buskens, C.J., Bouma, W.H., and Faculteit der Geneeskunde

Abstract

Bij de behandeling van borstkanker is het de standaardpraktijk: checken of de ‘schildwachtklier’ die bij de tumor hoort, vrij is van kwaadaardige cellen. Edwin van der Zaag pleit ervoor dezelfde procedure te volgen bij darmkanker. Chirurgen doen er volgens hem goed aan bij het wegnemen van een stuk darm met tumoren te checken welke lymfeklier de zogenoemde ‘schildwachtklier’ is die bij de tumor hoort. Daarna is het aan de patholoog om te beoordelen of deze vrij is van tumorcellen. Als eventuele vervolgbehandelingen worden afgestemd op de bevindingen in de schildwachtklier is veel winst te behalen, denkt Van der Zaag. Van de patiënten die worden geopereerd aan kanker in de dikke darm of de endeldarm, en die volgens de huidige procedure schone lymfeklieren hebben, krijgt ongeveer dertig procent toch weer kanker. Kijk je via de schildwachtprocedure, dan blijkt dertig procent van degenen met veronderstelde schone klieren toch tumorcellen in de schildwachtklier te hebben.

Published
2011

8. Costs of complications after colorectal cancer surgery in the Netherlands: Building the business case for hospitals

Author

Govaert, J.A., primary, Fiocco, M., additional, van Dijk, W.A., additional, Scheffer, A.C., additional, de Graaf, E.J.R., additional, Tollenaar, R.A.E.M., additional, Wouters, M.W.J.M., additional, Lamme, B., additional, Hess, D.A., additional, Belgers, H.J., additional, Guicherit, O.R., additional, Rosman, C., additional, Rutten, H.J.T., additional, Versluijs-Ossewaarde, F.N.L., additional, Van der Zaag, E.S., additional, Tseng, L.N.L., additional, Vles, W.J., additional, Pierik, E.G.J.M., additional, Prins, H.A., additional, Reemst, P.H.M., additional, Consten, E.C.J., additional, Koopal, S.A., additional, Neijenhuis, P.A., additional, Mannaerts, G.H.H., additional, Smits, A.B., additional, Burger, D.H.C., additional, van IJken, M.G.A., additional, Poortman, P., additional, Govaert, M.J.P.M., additional, Bleeker, W.A., additional, Den Boer, F.C., additional, Wit, F., additional, Kruyt, Ph.M., additional, Mearadji, A., additional, and Heikens, J.T., additional

Published
2015
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14. Towards resilience: Prehabilitation for the elderly with colorectal cancer

Author

Bruns, E.R.J., Bemelman, Wilhelmus A., van Munster, Barbara C., van Duijvendijk, Peter, van der Zaag, Edwin S., Surgery, AGEM - Digestive immunity, CCA - Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, Graduate School, Bemelman, W.A., van Munster, B.C., van Duijvendijk, P., van der Zaag, E.S., and Faculteit der Geneeskunde

Abstract

On average, frail patients have a fourfold higher risk of adverse outcomes such as postoperative complications and delayed recovery compared to their non-frail counterparts. Frailty can present itself in a wide array of phenotypes in which it can manifest itself ( e.g. ADL-dependent, depression, malnutrition, social isolation, etc.). The aim of this thesis is bifold. First, to define what frailty means in a surgical context. Second, to shift the idea of frailty towards an opportunity to revert this condition or at least make older patients more resilient to withstand a stressor such as a surgical intervention. Prehabilitation, defined as a multimodal approach to enhance a patient's condition prior to surgery has been gaining interest over the past years. The intervention is so intuitive that a layman might wonder why prehabiliation programs are only scarcely present in daily practice. An answer can lie in the fact that there is a lack of evidence for such behavioral interventions that require various disciplines (dietary specialists, physiotherapists, surgeons, geriatricians) to collaborate. As only 7% of all randomized controlled trials worldwide specifically focus on the elderly, the evidence is in this specific group is even more limited. The aim of this thesis is to assess the feasibility of prehabilitation in frail elderly patients, to focus on those who have the most to gain.

Published
2019

15. Evolving concepts in staging and treatment of colorectal cancer

Author

Sloothaak, D.A.M., Bemelman, W.A., Tanis, P.J., Buskens, C.J., van der Zaag, E.S., and Faculteit der Geneeskunde

Abstract

For localized colorectal cancer (CRC), lymph node metastases are the most powerful prognostic factor for disease specific and overall survival. In the first part of the thesis, we explore the prognostic role of lymph nodes in patients with stage I/II colon cancer. In these patients, nodal metastases are not detected with conventional pathological examination. Additional immunohistochemistry in the sentinel lymph node can reveal isolated tumour cells and micrometastasis. Studies in this thesis show that patients with micrometastasis have an increased risk of disease recurrence. Isolated tumour cells are not associated with worse prognosis. We also describe a positive correlation between lymph node size, lymph node harvest and prognosis. The second part of the thesis addresses several aspects of a multi-modality approach in the treatment of CRC. The aim of curative surgery for CRC is radical resection of the tumour. This can be difficult when tumours are large and advanced, or when emergency surgery is required because of obstructive tumours. In addition, microscopic tumour seeding within the peritoneal cavity might occur unnoticed. In these situations, surgical treatment alone is not sufficient to cure the patient and a multimodality approach should be applied. We analyzed the chance of a pathological complete tumour response after neoadjuvant chemoradiotherapy (CRT) for rectal cancer and calculated the optimal timing of surgery after (CRT). In addition, we describe the long term oncological follow up of patients that have been treated for obstructive colon cancer, and describe how adjuvant intraperitoneal chemotherapy might prevent the outgrow of peritoneal metastasis.

Published
2015

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