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2. Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation

Author

van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij‐Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago‐Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, and Klumperman, Judith

Published
2021
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5. Author Correction: Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions

Author

CMM Groep Klumperman, Cancer, CMM groep Liv, CMM Groep Burgering, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, Jonker, Caspar T H, Galmes, Romain, Veenendaal, Tineke, Ten Brink, Corlinda, van der Welle, Reini E N, Liv, Nalan, de Rooij, Johan, Peden, Andrew A, van der Sluijs, Peter, Margadant, Coert, Klumperman, Judith, CMM Groep Klumperman, Cancer, CMM groep Liv, CMM Groep Burgering, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, Jonker, Caspar T H, Galmes, Romain, Veenendaal, Tineke, Ten Brink, Corlinda, van der Welle, Reini E N, Liv, Nalan, de Rooij, Johan, Peden, Andrew A, van der Sluijs, Peter, Margadant, Coert, and Klumperman, Judith

Published
2021

6. Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation

Author

CMM Groep Klumperman, Cancer, CMM Groep Zwartkruis, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, Ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij-Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago-Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, Klumperman, Judith, CMM Groep Klumperman, Cancer, CMM Groep Zwartkruis, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, Ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij-Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago-Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, and Klumperman, Judith

Published
2021

7. Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion

Author

CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, Burns, Christian H, Yau, Belinda, Rodriguez, Anjelica, Triplett, Jenna, Maslar, Drew, An, You Sun, van der Welle, Reini E N, Kossina, Ross G, Fisher, Max R, Strout, Gregory W, Bayguinov, Peter O, Veenendaal, Tineke, Chitayat, David, Fitzpatrick, James A J, Klumperman, Judith, Kebede, Melkam A, Asensio, Cedric S, CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, Burns, Christian H, Yau, Belinda, Rodriguez, Anjelica, Triplett, Jenna, Maslar, Drew, An, You Sun, van der Welle, Reini E N, Kossina, Ross G, Fisher, Max R, Strout, Gregory W, Bayguinov, Peter O, Veenendaal, Tineke, Chitayat, David, Fitzpatrick, James A J, Klumperman, Judith, Kebede, Melkam A, and Asensio, Cedric S

Published
2021

8. Pancreatic β-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion.

Author

Burns CH, Yau B, Rodriguez A, Triplett J, Maslar D, An YS, van der Welle REN, Kossina RG, Fisher MR, Strout GW, Bayguinov PO, Veenendaal T, Chitayat D, Fitzpatrick JAJ, Klumperman J, Kebede MA, and Asensio CS

Subjects
Animals, Cell Line, Diabetes Mellitus genetics, Exocytosis physiology, Glucose Tolerance Test, Mice, Mice, Knockout, Rats, Vesicular Transport Proteins genetics, Diabetes Mellitus metabolism, Insulin Secretion genetics, Insulin-Secreting Cells metabolism, Secretory Vesicles metabolism, Vesicular Transport Proteins metabolism
Abstract

Insulin secretory granules (SGs) mediate the regulated secretion of insulin, which is essential for glucose homeostasis. The basic machinery responsible for this regulated exocytosis consists of specific proteins present both at the plasma membrane and on insulin SGs. The protein composition of insulin SGs thus dictates their release properties, yet the mechanisms controlling insulin SG formation, which determine this molecular composition, remain poorly understood. VPS41, a component of the endolysosomal tethering homotypic fusion and vacuole protein sorting (HOPS) complex, was recently identified as a cytosolic factor involved in the formation of neuroendocrine and neuronal granules. We now find that VPS41 is required for insulin SG biogenesis and regulated insulin secretion. Loss of VPS41 in pancreatic β-cells leads to a reduction in insulin SG number, changes in their transmembrane protein composition, and defects in granule-regulated exocytosis. Exploring a human point mutation, identified in patients with neurological but no endocrine defects, we show that the effect on SG formation is independent of HOPS complex formation. Finally, we report that mice with a deletion of VPS41 specifically in β-cells develop diabetes due to severe depletion of insulin SG content and a defect in insulin secretion. In sum, our data demonstrate that VPS41 contributes to glucose homeostasis and metabolism., (© 2020 by the American Diabetes Association.)

Published
2021
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