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34 results on '"van der Weerd N"'

1. Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Behçet's disease

Author: van der Houwen, T. B., Annink, M. E., Roelofs, J. J.T.H., Takkenberg, R. B., van Laar, J. A.M., van der Weerd, N. C., Hak, A. E., Kwakernaak, A. J., van der Houwen, T. B., Annink, M. E., Roelofs, J. J.T.H., Takkenberg, R. B., van Laar, J. A.M., van der Weerd, N. C., Hak, A. E., and Kwakernaak, A. J.
Abstract: Behçet's disease (BD) is an autoinflammatory disease with multifactorial and polygenic etiology, potentially involving arteries and veins of any size resulting in variable vessel vasculitis. We report a case of an Iranian male who presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression, anticoagulation and venous recanalization, he subsequently developed severe nephrotic-range proteinuria mimicking a primary renal disease which was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of the caval vein in the context of BD. Altogether, this case demonstrates the extensive spectrum of vascular disease in BD.
Published: 2024

2. Virus-Specific CD8+ T Cells Cross-Reactive to Donor-Alloantigen Are Transiently Present in the Circulation of Kidney Transplant Recipients Infected With CMV and/or EBV

Author: Heutinck, K. M., Yong, S. L., Tonneijck, L., van den Heuvel, H., van der Weerd, N. C., van der Pant, K. A. M. I., Bemelman, F. J., Claas, F. H. J., and ten Berge, I. J. M.
Published: 2016
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3. Abdominal wall phlebitis due to Prevotella bivia following renal transplantation in a patient with an occluded inferior vena cava

Author: Janssen, S., van Donselaar-van der Pant, K. A. M. I., van der Weerd, N. C., Develter, W., Bemelman, F. J., Grobusch, M. P., Idu, M. M., and ten Berge, I. J. M.
Published: 2013
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4. ABO-Incompatible Kidney Transplantation Outcomes: A Single Center Experience.: Abstract# A186

Author: van Sandwijk, M., Bemelman, F., van der Pant, K., van der Weerd, N., de Jong, T., and ten Berge, I.
Published: 2014

5. Decreased Graft Survival of Retransplants can Largely be Explained By Increased Hla-immunization

Author: Kamburova, Elena G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, Eric, Hack, C. E., van Reekum, F., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Plaisier, L., Seelen, M. A. J., Sanders, J. S. F., Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E., Gelens, M., Christiaans, M., van Ittersum, F., Nurmohamed, A., Lardy, N. M., Swelsen, W. T., van der Pant, K. A. M. I., van der Weerd, N. C., ten Berge, I. J. M., Bemelman, F. J., Hoitsma, A. J., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Heidt, Sebastiaan, Roelen, D. L., Claas, F. H. J., Otten, H. G., Groningen Institute for Organ Transplantation (GIOT), and Groningen Kidney Center (GKC)
Published: 2018

6. Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant

Author: Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G., Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., and Otten, H. G.
Published: 2018

7. Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant

Author: CTI Otten, Infection & Immunity, CDL Celdiagnostiek, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G., CTI Otten, Infection & Immunity, CDL Celdiagnostiek, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., and Otten, H. G.
Published: 2018

8. How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?

Author: Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M., Bots, M. L., Drop, A. C A D, Plaisier, L., Seelen, M. A J, Sanders, J. S F, Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G J, Vanderlocht, J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H L, van Ittersum, F. J., Nurmohamed, A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J M, Bemelman, F. J., Hoitsma, A., van der Boog, P. J M, de Fijter, J. W., Betjes, M. G H, Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G., Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M., Bots, M. L., Drop, A. C A D, Plaisier, L., Seelen, M. A J, Sanders, J. S F, Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G J, Vanderlocht, J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H L, van Ittersum, F. J., Nurmohamed, A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J M, Bemelman, F. J., Hoitsma, A., van der Boog, P. J M, de Fijter, J. W., Betjes, M. G H, Heidt, S., Roelen, D. L., Claas, F. H., and Otten, H. G.
Published: 2016

9. How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?

Author: CTI Otten, Infection & Immunity, CDL Celdiagnostiek, CTI, Lab exp immunologie / biomarkers ontst., MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M., Bots, M. L., Drop, A. C A D, Plaisier, L., Seelen, M. A J, Sanders, J. S F, Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G J, Vanderlocht, J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H L, van Ittersum, F. J., Nurmohamed, A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J M, Bemelman, F. J., Hoitsma, A., van der Boog, P. J M, de Fijter, J. W., Betjes, M. G H, Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G., CTI Otten, Infection & Immunity, CDL Celdiagnostiek, CTI, Lab exp immunologie / biomarkers ontst., MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M., Bots, M. L., Drop, A. C A D, Plaisier, L., Seelen, M. A J, Sanders, J. S F, Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G J, Vanderlocht, J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H L, van Ittersum, F. J., Nurmohamed, A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J M, Bemelman, F. J., Hoitsma, A., van der Boog, P. J M, de Fijter, J. W., Betjes, M. G H, Heidt, S., Roelen, D. L., Claas, F. H., and Otten, H. G.
Published: 2016

10. How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?

Author: Kamburova, E. G., primary, Wisse, B. W., additional, Joosten, I., additional, Allebes, W. A., additional, van der Meer, A., additional, Hilbrands, L. B., additional, Baas, M. C., additional, Spierings, E., additional, Hack, C. E., additional, van Reekum, F. E., additional, van Zuilen, A. D., additional, Verhaar, M., additional, Bots, M. L., additional, Drop, A. C. A. D., additional, Plaisier, L., additional, Seelen, M. A. J., additional, Sanders, J. S. F., additional, Hepkema, B. G., additional, Lambeck, A. J., additional, Bungener, L. B., additional, Roozendaal, C., additional, Tilanus, M. G. J., additional, Vanderlocht, J., additional, Voorter, C. E., additional, Wieten, L., additional, van Duijnhoven, E. M., additional, Gelens, M., additional, Christiaans, M. H. L., additional, van Ittersum, F. J., additional, Nurmohamed, A., additional, Lardy, N. M., additional, Swelsen, W., additional, van der Pant, K. A., additional, van der Weerd, N. C., additional, ten Berge, I. J. M., additional, Bemelman, F. J., additional, Hoitsma, A., additional, van der Boog, P. J. M., additional, de Fijter, J. W., additional, Betjes, M. G. H., additional, Heidt, S., additional, Roelen, D. L., additional, Claas, F. H., additional, and Otten, H. G., additional
Published: 2016
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11. Cardiovascular complications in CKD 5D

Author: Fusaro, M., primary, Fusaro, M., additional, Noale, M., additional, Tripepi, G., additional, D'angelo, A., additional, Miozzo, D., additional, Gallieni, M., additional, Study Group, P.-V., additional, Tsamelesvili, M., additional, Dimitriadis, C., additional, Papagianni, A., additional, Raidis, C., additional, Efstratiadis, G., additional, Memmos, D., additional, Mutluay, R., additional, Konca Degertekin, C., additional, Derici, U., additional, Deger, S. M., additional, Akkiyal, F., additional, Gultekin, S., additional, Gonen, S., additional, Tacoy, G., additional, Arinsoy, T., additional, Sindel, S., additional, Sanchez-Perales, C., additional, Vazquez, E., additional, Merino, E., additional, Perez Del Barrio, P., additional, Borrego, F. J., additional, Borrego, M. J., additional, Liebana, A., additional, Krzanowski, M., additional, Janda, K., additional, Dumnicka, P., additional, Krasniak, A., additional, Sulowicz, W., additional, Kim, Y.-O., additional, Yoon, S.-A., additional, Yun, Y.-S., additional, Song, H.-C., additional, Kim, B.-S., additional, Cheong, M. A., additional, Pasch, A., additional, Farese, S., additional, Floege, J., additional, Jahnen-Dechent, W., additional, Ohtake, T., additional, Furuya, R., additional, Iwagami, M., additional, Tsutsumi, D., additional, Mochida, Y., additional, Ishioka, K., additional, Oka, M., additional, Maesato, K., additional, Moriya, H., additional, Hidaka, S., additional, Kobayashi, S., additional, Guedes, A., additional, Malho Guedes, A., additional, Pinho, A., additional, Fragoso, A., additional, Cruz, A., additional, Mendes, P., additional, Morgado, E., additional, Bexiga, I., additional, Silva, A. P., additional, Neves, P., additional, Oyake, N., additional, Suzuki, K., additional, Itoh, S., additional, Yano, S., additional, Turkmen, K., additional, Kayikcioglu, H., additional, Ozbek, O., additional, Saglam, M., additional, Toker, A., additional, Tonbul, H. Z., additional, Gelev, S., additional, Trajceska, L., additional, Srbinovska, E., additional, Pavleska, S., additional, Amitov, V., additional, Selim, G., additional, Dzekova, P., additional, Sikole, A., additional, Bouarich, H., additional, Lopez, S., additional, Alvarez, C., additional, Arribas, I., additional, DE Sequera, P., additional, Rodriguez, D., additional, Tanaka, S., additional, Kanemitsu, T., additional, Sugahara, M., additional, Kobayashi, M., additional, Uchida, L., additional, Ishimoto, Y., additional, Kotera, N., additional, Tanimoto, S., additional, Tanabe, K., additional, Hara, K., additional, Sugimoto, T., additional, Mise, N., additional, Goldstein, B., additional, Turakhia, M., additional, Arce, C., additional, Winkelmayer, W., additional, Zayed, B. E.-D., additional, Said, K., additional, Nishimura, M., additional, Okamoto, Y., additional, Tokoro, T., additional, Nishida, M., additional, Hashimoto, T., additional, Iwamoto, N., additional, Takahashi, H., additional, Ono, T., additional, Sato, N., additional, Raimann, J., additional, Usvyat, L. A., additional, Sands, J., additional, Levin, N. W., additional, Kotanko, P., additional, Iwasaki, M., additional, Joki, N., additional, Tanaka, Y., additional, Ikeda, N., additional, Hayashi, T., additional, Kubo, S., additional, Imamura, T.-A., additional, Takahashi, Y., additional, Hirahata, K., additional, Imamura, Y., additional, Hase, H., additional, Claes, K., additional, Meijers, B., additional, Bammens, B., additional, Kuypers, D., additional, Naesens, M., additional, Vanrenterghem, Y., additional, Evenepoel, P., additional, Boscutti, G., additional, Calabresi, L., additional, Bosco, M., additional, Simonelli, S., additional, Boer, E., additional, Vitali, C., additional, Martone, M., additional, Mattei, P. L., additional, Franceschini, G., additional, Baligh, E., additional, El-Shafey, E., additional, Ezaat, A., additional, Zawada, A., additional, Rogacev, K., additional, Hummel, B., additional, Grun, O., additional, Friedrich, A., additional, Rotter, B., additional, Winter, P., additional, Geisel, J., additional, Fliser, D., additional, Heine, G. H., additional, Makino, J.-I., additional, Makino, K.-S., additional, Ito, T., additional, Genovesi, S., additional, Santoro, A., additional, Fabbrini, P., additional, Rossi, E., additional, Pogliani, D., additional, Stella, A., additional, Bonforte, G., additional, Remuzzi, G., additional, Bertoli, S., additional, Pozzi, C., additional, Pasquali, S., additional, Cagnoli, L., additional, Conte, F., additional, Buzadzic, I., additional, Tosic, J., additional, Dimkovic, N., additional, Djuric, Z., additional, Popovic, J., additional, Pejin Grubisa, I., additional, Barjaktarevic, N., additional, DI Napoli, A., additional, DI Lallo, D., additional, Salvatori, M. F., additional, Franco, F., additional, Chicca, S., additional, Guasticchi, G., additional, Onofriescu, M., additional, Hogas, S., additional, Luminita, V., additional, Mugurel, A., additional, Gabriel, V., additional, Laura, F., additional, Irina, M., additional, Adrian, C., additional, Bosch, E., additional, Baamonde, E., additional, Culebras, C., additional, Perez, G., additional, El Hayek, B., additional, Ramirez, J. I., additional, Ramirez, A., additional, Garcia, C., additional, Lago, M., additional, Toledo, A., additional, Checa, M. D., additional, Taira, T., additional, Hirano, T., additional, Nohtomi, K., additional, Hyodo, T., additional, Chiba, T., additional, Saito, A., additional, Kim, Y. K., additional, Choi, E. J., additional, Yang, C. W., additional, Kim, Y.-S., additional, Lim, P. S., additional, Ming Ying, W., additional, Ya-Chung, J., additional, Zaripova, I., additional, Kayukov, I., additional, Essaian, A., additional, Nimgirova, A., additional, Young, H., additional, Dungey, M., additional, Watson, E. L., additional, Baines, R., additional, Burton, J. O., additional, Smith, A. C., additional, Yamazaki, K., additional, Bossola, M., additional, Colacicco, L., additional, Scribano, D., additional, Vulpio, C., additional, Tazza, L., additional, Okada, T., additional, Okada, N., additional, Michibata, I., additional, Yura, T., additional, Montero, N., additional, Soler, M., additional, Pascual, M., additional, Barrios, C., additional, Marquez, E., additional, Rodriguez, E., additional, Orfila, M. A., additional, Cao, H., additional, Arcos, E., additional, Comas, J., additional, Pascual, J., additional, Ferrario, M., additional, Garzotto, F., additional, Sironi, T., additional, Monacizzo, S., additional, Basso, F., additional, Cruz, D. N., additional, Moissl, U., additional, Tetta, C., additional, Signorini, M. G., additional, Cerutti, S., additional, Ronco, C., additional, Mostovaya, I., additional, Grooteman, M., additional, Van den Dorpel, M., additional, Penne, L., additional, Van der Weerd, N., additional, Mazairac, A., additional, Den Hoedt, C., additional, Levesque, R., additional, Nube, M., additional, Ter Wee, P., additional, Bots, M., additional, Blankestijn, P., additional, Liu, J., additional, MA, K. L., additional, Zhang, X., additional, Liu, B. C., additional, Vladu, I.-D., additional, Mustafa, R., additional, Cana-Ruiu, D., additional, Vaduva, C., additional, Grauntanu, C., additional, Mota, E., additional, Singh, R., additional, Abbasian, N., additional, Stover, C., additional, Brunskill, N., additional, Burton, J., additional, Herbert, K., additional, Bevington, A., additional, Wu, M., additional, Tang, R.-N., additional, Gao, M., additional, Liu, H., additional, Chen, L., additional, LV, L.-L., additional, Liu, B.-C., additional, Nikodimopoulou, M., additional, Liakos, S., additional, Kapoulas, S., additional, Karvounis, C., additional, Fedak, D., additional, Kuzniewski, M., additional, Paulina, D., additional, Kusnierz-Cabala, B., additional, Kapusta, M., additional, Solnica, B., additional, Junque, A., additional, Vicent, E. S., additional, Moreno, L., additional, Fulquet, M., additional, Duarte, V., additional, Saurina, A., additional, Pou, M., additional, Macias, J., additional, Lavado, M., additional, Ramirez de Arellano, M., additional, Ryuzaki, M., additional, Nakamoto, H., additional, Kinoshita, S., additional, Kobayashi, E., additional, Takimoto, C., additional, Shishido, T., additional, Enia, G., additional, Torino, C., additional, Tripepi, R., additional, Panuccio, V., additional, Postorino, M., additional, Clementi, A., additional, Garozzo, M., additional, Bonanno, G., additional, Boito, R., additional, Natale, G., additional, Cicchetti, T., additional, Chippari, A., additional, Logozzo, D., additional, Alati, G., additional, Cassani, S., additional, Sellaro, A., additional, Zoccali, C., additional, Quiroga, B., additional, Verde, E., additional, Abad, S., additional, Vega, A., additional, Goicoechea, M., additional, Reque, J., additional, Lopez-Gomez, J. M., additional, Luno, J., additional, Cabre Menendez, C., additional, Moles, V., additional, Vives, J. P., additional, Villa, D., additional, Vinas, J., additional, Compte, T., additional, Arruche, M., additional, Diaz, C., additional, Soler, J., additional, Aguilera, J., additional, Martinez Vea, A., additional, De Mauri, A., additional, David, P., additional, Conte, M. M., additional, Chiarinotti, D., additional, Ruva, C. E., additional, De Leo, M., additional, Bargnoux, A.-S., additional, Morena, M., additional, Jaussent, I., additional, Chalabi, L., additional, Bories, P., additional, Dion, J.-J., additional, Henri, P., additional, Delage, M., additional, Dupuy, A.-M., additional, Badiou, S., additional, Canaud, B., additional, Cristol, J.-P., additional, Sironi, E., additional, Pieruzzi, F., additional, Galbiati, E., additional, Vigano, M. R., additional, Anpalakhan, S., additional, Rocha, S., additional, Chitalia, N., additional, Sharma, R., additional, Kaski, J. C., additional, Chambers, J., additional, Goldsmith, D., additional, Banerjee, D., additional, Cernaro, V., additional, Lacquaniti, A., additional, Lupica, R., additional, Lucisano, S., additional, Fazio, M. R., additional, Donato, V., additional, Buemi, M., additional, Segalen, I., additional, Vinsonneau, U., additional, Tanquerel, T., additional, Quiniou, G., additional, Le Meur, Y., additional, Seibert, E., additional, Girndt, M., additional, Zohles, K., additional, Ulrich, C., additional, Kluttig, A., additional, Nuding, S., additional, Swenne, C., additional, Kors, J., additional, Werdan, K., additional, Fiedler, R., additional, Van der Weerd, N. C., additional, Grooteman, M. P., additional, Van den Dorpel, M. A., additional, Nube, M. J., additional, Wetzels, J., additional, Swinkels, D. W., additional, Ter Wee, P. M., additional, Khandekar, A., additional, Khandge, J., additional, Lee, J. E., additional, Moon, S. J., additional, Choi, K. H., additional, Lee, H. Y., additional, Kim, B. S., additional, Tuaillon, E., additional, Rodriguez, A., additional, Chenine, L., additional, Vendrell, J.-P., additional, Sue, Y.-M., additional, Tang, C.-H., additional, Chen, Y.-C., additional, Segura, P., additional, Garcia Cortes, M. J., additional, Gil, J. M., additional, Biechy, M. M., additional, Poulikakos, D., additional, Shah, A., additional, Persson, M., additional, Dattolo, P., additional, Amidone, M., additional, Michelassi, S., additional, Moriconi, L., additional, Betti, G., additional, Conti, P., additional, Rosati, A., additional, Mannarino, A., additional, Panichi, V., additional, Pizzarelli, F., additional, Klejna, K., additional, Naumnik, B., additional, Koc-Zorawska, E., additional, Mysliwiec, M., additional, Dimitrie, S., additional, Simona, H., additional, Mihaela, O., additional, Gabriela, O., additional, Radu, S., additional, Octavian, P., additional, Akdam, H., additional, Akar, H., additional, Yenicerioglu, Y., additional, Kucuk, O., additional, Kurt Omurlu, I., additional, Thambiah, S., additional, Roplekar, R., additional, Manghat, P., additional, Fogelman, I., additional, Fraser, W., additional, Hampson, G., additional, Likaj, E., additional, Caco, G., additional, Seferi, S., additional, Rroji, M., additional, Barbullushi, M., additional, Thereska, N., additional, Serban, A., additional, Carmen, V., additional, Cristian, S., additional, Silvia, L., additional, and Covic, A., additional
Published: 2012
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12. ABO-Incompatible Kidney Transplantation Outcomes: A Single Center Experience.

Author: van Sandwijk, M., primary, Bemelman, F., additional, van der Pant, K., additional, van der Weerd, N., additional, de Jong, T., additional, and ten Berge, I., additional
Published: 2014
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13. DIALYSIS. PATHOPHYSIOLOGY AND CLINICAL STUDIES

Author: Humalda, J. K., primary, Assa, S., additional, Navis, G. J., additional, Franssen, C. F. M., additional, De Borst, M. H., additional, Ogawa, H., additional, Ota, Y., additional, Watanabe, T., additional, Watanabe, Y., additional, Nishii, H., additional, Sato, A., additional, Waniewski, J., additional, Debowska, M., additional, Wojcik-Zaluska, A., additional, Ksiazek, A., additional, Zaluska, W., additional, Guastoni, C. M., additional, Turri, C., additional, Toma, L., additional, Rombola, G., additional, Frattini, G., additional, Romei Longhena, G., additional, Teatini, U., additional, Siriopol, D.-C., additional, Stuard, S., additional, Ciolan, A., additional, Mircescu, G., additional, Raluca, D., additional, Nistor, I., additional, Covic, A., additional, De Roij Van Zuijdewijn, C. L., additional, Chapdelaine, I., additional, Nube, M. J., additional, Blankestijn, P. J., additional, Bots, M. L., additional, Konings, S. J., additional, Van Den Dorpel, M. A., additional, Van Der Weerd, N. C., additional, Ter Wee, P. M., additional, Grooteman, M. P., additional, Djuric, P. S., additional, Jankovic, A., additional, Tosic, J., additional, Bajcetic, S., additional, Damjanovic, T., additional, Popovic, J., additional, Dimkovic, N., additional, Marinkovic, J., additional, Djuric, Z., additional, Knezevic, V., additional, Lazarevic, T., additional, Ljubenovic, S., additional, Markovic, R., additional, Rabrenovic, V., additional, Djukanovic, L., additional, Radovic Maslarevic, V., additional, Mathrani, V., additional, Drew, P., additional, Chess, J. I., additional, Williams, A. I., additional, Robertson, S., additional, Jibani, M., additional, Aithal, V. I., additional, Kumwenda, M., additional, Roberts, G., additional, Mikhail, A. I., additional, Grzegorzewska, A. E., additional, Ostromecki, G., additional, Mostowska, A., additional, Sowi ska, A., additional, Jagodzi ski, P. P., additional, Wu, H.-Y., additional, Chen, H.-Y., additional, Hsu, S.-P., additional, Pai, M.-F., additional, Yang, J.-Y., additional, Peng, Y.-S., additional, Hirose, M., additional, Hasegawa, T., additional, Kaneshima, N., additional, Sasai, F., additional, Komukai, D., additional, Takahashi, K., additional, Koiwa, F., additional, Shishido, K., additional, Yoshimura, A., additional, Selim, G., additional, Stojceva-Taneva, O., additional, Tozija, L., additional, Dzekova-Vidimliski, P., additional, Trajceska, L., additional, Petronievic, Z., additional, Gelev, S., additional, Amitov, V., additional, Sikole, A., additional, Moon, S. J., additional, Yoon, S. Y., additional, Shin, D. H., additional, Lee, J. E., additional, Kim, H.-J., additional, Park, H.-C., additional, Hadjiyannakos, D., additional, Filiopoulos, V., additional, Loukas, G., additional, Pagonis, S., additional, Andriopoulos, C., additional, Drakou, A., additional, Vlassopoulos, D., additional, Catarino, C., additional, Cunha, P., additional, Ribeiro, S., additional, Rocha-Pereira, P., additional, Reis, F., additional, Sameiro-Faria, M., additional, Miranda, V., additional, Bronze-Rocha, E., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, De Mauri, A., additional, Brambilla, M., additional, Chiarinotti, D., additional, Lizio, D., additional, Matheoud, R., additional, Conti, N., additional, Conte, M. M., additional, Carriero, A., additional, De Leo, M., additional, Karpetas, A. V., additional, Sarafidis, P. A., additional, Georgianos, P. I., additional, Koutroumpas, G., additional, Divanis, D., additional, Vakianis, P., additional, Tzanis, G., additional, Raptopoulou, K., additional, Protogerou, A., additional, Stamatiadis, D., additional, Syrganis, C., additional, Liakopoulos, V., additional, Efstratiadis, G., additional, Lasaridis, A. N., additional, Tersi, M., additional, Stamatiadis, D. N., additional, Kuczera, P., additional, Adamczak, M., additional, Wiecek, A., additional, Bove, S., additional, Giacon, B., additional, Corradini, R., additional, Prati, E., additional, Brognoli, M., additional, Tommasi, A., additional, Sereni, L., additional, Palladino, G., additional, Moriya, H., additional, Mochida, Y., additional, Ishioka, K., additional, Oka, M., additional, Maesato, K., additional, Hidaka, S., additional, Ohtake, T., additional, Kobayashi, S., additional, Moura, A., additional, Madureira, J., additional, Alija, P., additional, Fernandes, J. C., additional, Oliveira, J. G., additional, Lopez, M., additional, Filgueiras, M., additional, Amado, L., additional, Vieira, M., additional, Seok, J.-H., additional, Choi, H. Y., additional, Ha, S. K., additional, Park, H. C., additional, Bossola, M., additional, Laudisio, A., additional, Antocicco, M., additional, Tazza, L., additional, Colloca, G., additional, Tosato, M., additional, Zuccala, G., additional, Ettema, E. M., additional, Kuipers, J., additional, Groen, H., additional, Gansevoort, R. T., additional, Stade, K., additional, Bakker, S. J. L., additional, Gaillard, C. A. J. M., additional, Westerhuis, R., additional, Bacchetta, J., additional, Couchoud, K., additional, Semlali, S., additional, Sellier-Leclerc, A.-L., additional, Bertholet-Thomas, A., additional, Cartier, R., additional, Cochat, P., additional, Ranchin, B., additional, Kim, J. C., additional, Park, K., additional, Van Ende, C., additional, Wilmes, D., additional, Lecouvet, F. E., additional, Labriola, L., additional, Cuvelier, R., additional, Van Ingelgem, G., additional, Jadoul, M., additional, Doriana, C., additional, David, P., additional, Capurro, F., additional, Brustia, M., additional, Ruva, C. E., additional, Giungi, S., additional, Di Stasio, E., additional, Lemesch, S., additional, Leber, B., additional, Horvath, A., additional, Ribitsch, W., additional, Schilcher, G., additional, Zettel, G., additional, Tawdrous, M., additional, Rosenkranz, A. R., additional, Stadlbauer-Kollner, V., additional, Matsushima, H., additional, Oyama, A., additional, Bosch Benitez-Parodi, E., additional, Baamonde Laborda, E., additional, Batista Garcia, F., additional, Perez Suarez, G., additional, Anton Perez, G., additional, Garcia Canton, C., additional, Toledo Gonzalez, A., additional, Lago Alonso, M. M., additional, Checa Andres, M. D., additional, Cobo, G., additional, Di Gioia, C., additional, Camacho, R., additional, Garcia Lacalle, C., additional, Ortega, O., additional, Rodriguez, I., additional, Herrero, J., additional, Oliet, A., additional, Ortiz, M., additional, Mon, C., additional, Vigil, A., additional, Gallar, P., additional, Pellu, V., additional, Nebiolo, P. E., additional, Sasaki, K., additional, Yamguchi, S., additional, Hesaka, A., additional, Iwahashi, E., additional, Sakai, S., additional, Fujimoto, T., additional, Minami, S., additional, Fujita, Y., additional, Yokoyama, K., additional, Shutov, E., additional, Ryabinskya, G., additional, Lashutin, S., additional, Gorelova, E., additional, Volodicheva, E., additional, Podesta, M. A., additional, Cancarini, G., additional, Cucchiari, D., additional, Montanelli, A., additional, Badalamenti, S., additional, Graziani, G., additional, Distasio, E., additional, Pchelin, I., additional, Shishkin, A., additional, Fedorova, Y., additional, Kao, C.-C., additional, Chu, T.-S., additional, Tsai, T.-J., additional, Wu, K.-D., additional, Wu, M.-S., additional, Raikou, V., additional, Kaisidis, P., additional, Tsamparlis, E., additional, Kanellopoulos, P., additional, Boletis, J., additional, Ueda, A., additional, Hirayama, A., additional, Owada, S., additional, Nagai, K., additional, Saito, C., additional, and Yamagata, K., additional
Published: 2014
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14. Dalende prevalentie van Helicobacter pylori: consequenties voor de behandeling van gastroduodenale ulcera

Author: van der Weerd, N. C., Cats, A., Thijs, J. C., Festen, H. P., Meuwissen, S. G., Kuipers, E. J., and Other departments
Subjects: digestive system diseases
Abstract: Four patients with gastroduodenal ulcers in the absence of Helicobacter pylori illustrate the decreasing prevalence of this microorganism. One was a 19-year-old boy with nausea, diarrhoea and weight loss caused by multiple gastroduodenal ulcers due to the Zollinger-Ellison syndrome. Another was a 36-year-old man with abdominal discomfort caused by an ulcer due to Crohn's disease. The other two cases concerned a 29-year-old man and a 68-year-old woman with relapsing ulcer disease and active bleeding, in whom no causal factors could be determined. Recent studies suggest a decreasing prevalence of H. pylori leading to both a relative and an absolute decrease of gastroduodenal ulcers attributed to H. pylori. Future treatment strategies will have to take these altered prevalence rates into consideration
Published: 2000

15. Abdominal wall phlebitis due to Prevotella bivia following renal transplantation in a patient with an occluded inferior vena cava

Author: Janssen, S., primary, van Donselaar-van der Pant, K. A. M. I., additional, van der Weerd, N. C., additional, Develter, W., additional, Bemelman, F. J., additional, Grobusch, M. P., additional, Idu, M. M., additional, and ten Berge, I. J. M., additional
Published: 2012
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16. Extracorporeal dialysis: techniques and adequacy

Author: Donadio, C., primary, Kanaki, A., additional, Martin-Gomez, A., additional, Garcia, S., additional, Palacios-Gomez, M., additional, Donadio, C., additional, Calia, D., additional, Colombini, E., additional, DI Francesco, F., additional, Ghimenti, S., additional, Onor, M., additional, Tognotti, D., additional, Fuoco, R., additional, Marka-Castro, E., additional, Torres Zamora, M. I., additional, Giron-Mino, J., additional, Jaime-Solis, M. A., additional, Arteaga, L. M., additional, Romero, H., additional, Akonur, A., additional, Leypoldt, K., additional, Asola, M., additional, Culleton, B., additional, Eloot, S., additional, Glorieux, G., additional, Nathalie, N., additional, Vanholder, R., additional, Perez de Jose, A., additional, Verdalles Guzman, U., additional, Abad Esttebanez, S., additional, Vega Martinez, A., additional, Barraca, D., additional, Yuste, C., additional, Bucalo, L., additional, Rincon, A., additional, Lopez-Gomez, J. M., additional, Bataille, P., additional, Celine, P., additional, Raymond, A., additional, Francois, G., additional, Herve, L., additional, Michel, D., additional, Jean Louis, R., additional, Zhu, F., additional, Kotanko, P., additional, Thijssen, S., additional, Levin, N. W., additional, Papamichail, N., additional, Bougiakli, M., additional, Gouva, C., additional, Antoniou, S., additional, Gianitsi, S., additional, Vlachopanou, A., additional, Chachalos, S., additional, Naka, K., additional, Kaarsavvidou, D., additional, Katopodis, K., additional, Michalis, L., additional, Sasaki, K., additional, Yasuda, K., additional, Yamato, M., additional, Surace, A., additional, Rovatti, P., additional, Steckiph, D., additional, Bandini, R., additional, Severi, S., additional, Dellacasa Bellingegni, A., additional, Santoro, A., additional, Arias, M., additional, Sentis, A., additional, Perez, N., additional, Fontsere, N., additional, Vera, M., additional, Rodriguez, N., additional, Arcal, C., additional, Ortega, N., additional, Uriza, F., additional, Cases, A., additional, Maduell, F., additional, Abbas, S. R., additional, Georgianos, P., additional, Sarafidis, P., additional, Nikolaidis, P., additional, Lasaridis, A., additional, Ahmed, A., additional, Kaoutar, H., additional, Mohammed, B., additional, Zouhir, O., additional, Balter, P., additional, Ginsberg, N., additional, Taylor, P., additional, Sullivan, T., additional, Usvyat, L. A., additional, Zabetakis, P., additional, Moissl, U., additional, Ferrario, M., additional, Garzotto, F., additional, Wabel, P., additional, Cruz, D., additional, Tetta, C., additional, Signorini, M. G., additional, Cerutti, S., additional, Brendolan, A., additional, Ronco, C., additional, Heaf, J., additional, Axelsen, M., additional, Pedersen, R. S., additional, Amine, H., additional, Oualim, Z., additional, Ammirati, A. L., additional, Guimaraes de Souza, N. K., additional, Nemoto Matsui, T., additional, Luiz Vieira, M., additional, Alves de Oliveira, W. A., additional, Fischer, C. H., additional, Dias Carneiro, F., additional, Iizuka, I. J., additional, Aparecida de Souza, M., additional, Mallet, A. C., additional, Cruz Andreoli, M. C., additional, Cardoso Dos Santos, B. F., additional, Rosales, L., additional, Dou, Y., additional, Carter, M., additional, Testa, A., additional, Sottini, L., additional, Giacon, B., additional, Prati, E., additional, Loschiavo, C., additional, Brognoli, M., additional, Marseglia, C., additional, Tommasi, A., additional, Sereni, L., additional, Palladino, G., additional, Bove, S., additional, Bosticardo, G., additional, Schillaci, E., additional, Detoma, P., additional, Bergia, R., additional, Park, J. W., additional, Moon, S. J., additional, Choi, H. Y., additional, Ha, S. K., additional, Park, H.-C., additional, Liao, Y., additional, Zhang, L., additional, Fu, P., additional, Igarashi, H., additional, Suzuki, N., additional, Esashi, S., additional, Masakane, I., additional, Panichi, V., additional, De Ferrari, G., additional, Saffiotti, S., additional, Sidoti, A., additional, Biagioli, M., additional, Bianchi, S., additional, Imperiali, P., additional, Gabrielli, C., additional, Conti, P., additional, Patrone, P., additional, Rombola, G., additional, Falqui, V., additional, Mura, C., additional, Icardi, A., additional, Rosati, A., additional, Santori, F., additional, Mannarino, A., additional, Bertucci, A., additional, Jeong, J., additional, Kim, O. K., additional, Kim, N. H., additional, Bots, M., additional, Den Hoedt, C., additional, Grooteman, M. P., additional, Van der Weerd, N. C., additional, Mazairac, A. H. A., additional, Levesque, R., additional, Ter Wee, P. M., additional, Nube, M. J., additional, Blankestijn, P., additional, Van den Dorpel, M. A., additional, Park, Y., additional, Jeon, J., additional, Tessitore, N., additional, Bedogna, V., additional, Girelli, D., additional, Corazza, L., additional, Jacky, P., additional, Guillaume, Q., additional, Julien, B., additional, Marcinkowski, W., additional, Drozdz, M., additional, Milkowski, A., additional, Rydzynska, T., additional, Prystacki, T., additional, August, R., additional, Benedyk-Lorens, E., additional, Bladek, K., additional, Cina, J., additional, Janiszewska, G., additional, Kaczmarek, A., additional, Lewinska, T., additional, Mendel, M., additional, Paszkot, M., additional, Trafidlo, E., additional, Trzciniecka-Kloczkowska, M., additional, Vasilevsky, A., additional, Konoplev, G., additional, Lopatenko, O., additional, Komashnya, A., additional, Visnevsky, K., additional, Gerasimchuk, R., additional, Neivelt, I., additional, Frorip, A., additional, Vostry, M., additional, Racek, J., additional, Rajdl, D., additional, Eiselt, J., additional, Malanova, L., additional, Pechter, U., additional, Selart, A., additional, Ots-Rosenberg, M., additional, Krieter, D. H., additional, Seidel, S., additional, Merget, K., additional, Lemke, H.-D., additional, Wanner, C., additional, Canaud, B., additional, Rodriguez, A., additional, Morgenroth, A., additional, Von Appen, K., additional, Dragoun, G.-P., additional, Fluck, R., additional, Fouque, D., additional, Lockridge, R., additional, Motomiya, Y., additional, Uji, Y., additional, Hiramatsu, T., additional, Ando, Y., additional, Furuta, M., additional, Kuragano, T., additional, Kida, A., additional, Yahiro, M., additional, Otaki, Y., additional, Hasuike, Y., additional, Nonoguchi, H., additional, Nakanishi, T., additional, Sain, M., additional, Kovacic, V., additional, Ljutic, D., additional, Radic, J., additional, Jelicic, I., additional, Yalin, S. F., additional, Trabulus, S., additional, Yalin, A. S., additional, Altiparmak, M. R., additional, Serdengecti, K., additional, Ohtsuka, A., additional, Fukami, K., additional, Ishikawa, K., additional, Ando, R., additional, Kaida, Y., additional, Adachi, T., additional, Sugi, K., additional, Okuda, S., additional, Nesterova, O. B., additional, Suglobova, E. D., additional, Golubev, R. V., additional, Vasiliev, A. N., additional, Lazeba, V. A., additional, Smirnov, A. V., additional, Arita, K., additional, Kihara, E., additional, Maeda, K., additional, Oda, H., additional, Doi, S., additional, Masaki, T., additional, Hidaka, S., additional, Ishioka, K., additional, Oka, M., additional, Moriya, H., additional, Ohtake, T., additional, Nomura, S., additional, Kobayashi, S., additional, Wagner, S., additional, Gmerek, A., additional, Wagner, J., additional, Wizemann, V., additional, Eftimovska - Otovic, N., additional, Spaseska-Gjurovska, K., additional, Bogdanovska, S., additional, Babalj - Banskolieva, E., additional, Milovanceva, M., additional, Grozdanovski, R., additional, Pisani, A., additional, Riccio, E., additional, Mancini, A., additional, Ambuhl, P., additional, Astrid, S., additional, Ivana, P., additional, Martin, H., additional, Thomas, K., additional, Hans-Rudolf, R., additional, Daniel, A., additional, Denes, K., additional, Marco, M., additional, Wuthrich, R. P., additional, Andreas, S., additional, Andrulli, S., additional, Altieri, P., additional, Sau, G., additional, Bolasco, P., additional, Pedrini, L. A., additional, Basile, C., additional, David, S., additional, Feriani, M., additional, Nebiolo, P. E., additional, Ferrara, R., additional, Casu, D., additional, Logias, F., additional, Tarchini, R., additional, Cadinu, F., additional, Passaghe, M., additional, Fundoni, G., additional, Villa, G., additional, DI Iorio, B. R., additional, Zoccali, C., additional, Locatelli, F., additional, Hamamoto, M., additional, Lee, D.-Y., additional, Kim, B., additional, Moon, K. H., additional, LI, Z., additional, Ahrenholz, P., additional, Winkler, R. E., additional, Waitz, G., additional, Wolf, H., additional, Grundstrom, G., additional, Alquist, M., additional, Holmquist, M., additional, Christensson, A., additional, Bjork, P., additional, Abdgawad, M., additional, Ekholm, L., additional, Segelmark, M., additional, Corsi, C., additional, De Bie, J., additional, Mambelli, E., additional, Mortara, D., additional, Arroyo, D., additional, Panizo, N., additional, Quiroga, B., additional, Reque, J., additional, Melero, R., additional, Rodriguez-Ferrero, M., additional, Rodriguez-Benitez, P., additional, Anaya, F., additional, Luno, J., additional, Ragon, A., additional, James, A., additional, Brunet, P., additional, Ribeiro, S., additional, Faria, M. S., additional, Rocha, S., additional, Rodrigues, S., additional, Catarino, C., additional, Reis, F., additional, Nascimento, H., additional, Fernandes, J., additional, Miranda, V., additional, Quintanilha, A., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, Arund, J., additional, Tanner, R., additional, Fridolin, I., additional, Luman, M., additional, Clajus, C., additional, Kielstein, J. T., additional, Haller, H., additional, Libutti, P., additional, Lisi, P., additional, Vernaglione, L., additional, Casucci, F., additional, Losurdo, N., additional, Teutonico, A., additional, Lomonte, C., additional, Krisp, C., additional, Wolters, D. A., additional, Matsuyama, M., additional, Tomo, T., additional, Ishida, K., additional, Matsuyama, K., additional, Nakata, T., additional, Kadota, J., additional, Caiazzo, M., additional, Monari, E., additional, Cuoghi, A., additional, Bellei, E., additional, Bergamini, S., additional, Tomasi, A., additional, Baranger, T., additional, Seniuta, P., additional, Berge, F., additional, Drouillat, V., additional, Frangie, C., additional, Rosier, E., additional, Labonia, W., additional, Lescano, A., additional, Rubio, D., additional, Von der Lippe, N., additional, Jorgensen, J. A., additional, Osthus, T. B., additional, Waldum, B., additional, Os, I., additional, Bossola, M., additional, DI Stasio, E., additional, Antocicco, M., additional, Tazza, L., additional, Griveas, I., additional, Karameris, A., additional, Pasadakis, P., additional, Savica, V., additional, Santoro, D., additional, Saitta, S., additional, Tigano, V., additional, Bellinghieri, G., additional, Gangemi, S., additional, Daniela, R., additional, Checherita, I. A., additional, Ciocalteu, A., additional, Vacaroiu, I. A., additional, Niculae, A., additional, Stefaniak, E., additional, Pietrzak, I., additional, Krupa, D., additional, Garred, L., additional, Mancini, E., additional, Corrazza, L., additional, Atti, M., additional, Afsar, B., additional, Stamopoulos, D., additional, Mpakirtzi, N., additional, Gogola, B., additional, Zeibekis, M., additional, Stivarou, D., additional, Panagiotou, M., additional, Grapsa, E., additional, Vega Vega, O., additional, Barraca Nunez, D., additional, Fernandez-Lucas, M., additional, Gomis, A., additional, Teruel, J. L., additional, Elias, S., additional, Quereda, C., additional, Hignell, L., additional, Humphrey, S., additional, Pacy, N., additional, and Afentakis, N., additional
Published: 2012
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17. Optimizing haemodiafiltration: tools, strategy and remaining questions

Author: Penne, E. L., primary, van Berkel, T., additional, van der Weerd, N. C., additional, Grooteman, M. P. C., additional, and Blankestijn, P. J., additional
Published: 2009
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18. Results from the RISCAVID study: is haemodiafiltration associated with improved survival?

Author: Penne, E. L., primary, van der Weerd, N. C., additional, Grooteman, M. P., additional, and Blankestijn, P. J., additional
Published: 2008
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19. Reply

Author: van der Weerd, N. C., primary, Penne, E. L., additional, van den Dorpel, M. A., additional, Grooteman, M. P. C., additional, Nube, M. J., additional, Bots, M. L., additional, ter Wee, P. M., additional, and Blankestijn, P. J., additional
Published: 2008
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20. Haemodiafiltration: promise for the future?

Author: van der Weerd, N. C., primary, Penne, E. L., additional, van den Dorpel, M. A., additional, Grooteman, M. P.C., additional, Nube, M. J., additional, Bots, M. L., additional, ter Wee, P. M., additional, and Blankestijn, P. J., additional
Published: 2007
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21. Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.

Author: van der Weerd N, Mulders P, Vrijsen J, van Oort J, Collard R, van Eijndhoven P, and Tendolkar I
Subjects: Humans, Female, Male, Cross-Sectional Studies, Adult, Comorbidity, Young Adult, Brain diagnostic imaging, Brain pathology, Middle Aged, Magnetic Resonance Imaging, Stress, Psychological diagnostic imaging, Stress, Psychological pathology, Hydrocortisone metabolism, Hair pathology, Adverse Childhood Experiences, Gray Matter diagnostic imaging, Gray Matter pathology, Neurodevelopmental Disorders diagnostic imaging, Neurodevelopmental Disorders pathology, Neurodevelopmental Disorders physiopathology
Abstract: Childhood adversity (CA), including childhood adverse life events, increases the risk for development of psychiatric disorders later in life. Both CA and psychiatric disorders are associated with structural brain changes and dysfunctional hypothalamic-pituitary-adrenal-axis. However, many studies investigated single diagnostic and single regions of interest of the brain, and did not take stress reactivity into account. We investigated associations of CA and cortisol levels with gray matter volume and cortical thickness, in a whole-brain manner. Primary analysis constituted of a transdiagnostic approach, followed by a moderation analysis to investigate the influence of diagnosis. Patients with stress-related and/or neurodevelopmental disorders and matched healthy controls underwent an magnetic resonance imaging scan, next to assessing hair cortisol levels and CA/life events. CA was reported by 62-72% of the patients versus 33% of the controls. Primary transdiagnostic linear regression analyses revealed that CA was not associated with gray matter volume, while childhood life events were associated with lower right thalamic volume. Hair cortisol was not associated with any lobe volume. None of the associations were moderated by diagnosis. In conclusion, CA is a risk factor that needs to be taken into account when investigating psychiatric disorders. Yet the relationship with structural brain changes and stress reactivity is less clear than postulated on the basis of more seed-based studies., (© 2024 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)
Published: 2024
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22. Different growth patterns in two siblings with Schimke immuno-osseous-dysplasia.

Author: Bokenkamp A, Bouts A, van der Weerd N, Levtchenko E, Haffner D, and Zivicnjak M
Abstract: Schimke immuno-osseous-dysplasia (SIOD) is an autosomal recessive systemic disease due to pathogenic variants in SMARCAL1. Manifestations include nephrotic syndrome (NS), kidney failure, T-cell dysfunction, vaso-occlusive disease, and disproportionate short stature, a general feature of this disease. Here, we present a markedly different growth pattern in two brothers with SIOD sharing the same homozygous R561C missense variant. The index patient presented at the age of 11 years with NS and severely disproportionate short stature, followed by kidney failure at the age of 16, and severely reduced adult height (z-score - 8.0). In contrast, the younger brother showed normal growth until the age of 8 years. Mild proteinuria was noted at the age of 4.5, followed by NS at 9.5 years, kidney failure at 11 years, progressive disproportionate stature, and reduced adult height (z-score - 4.5). Both brothers had comparable disproportion in adulthood (sitting height index z-score - 0.88 and - 1.44, respectively)., (© 2024. The Author(s).)
Published: 2024
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23. Porto-sinusoidal vascular disorder and nephrotic-range proteinuria due to venous vasculitis in Behçet's disease.

Author: van der Houwen TB, Annink ME, Roelofs JJTH, Takkenberg RB, van Laar JAM, van der Weerd NC, Hak AE, and Kwakernaak AJ
Subjects: Humans, Male, Vasculitis etiology, Behcet Syndrome complications, Proteinuria etiology
Abstract: Behçet's disease (BD) is an autoinflammatory disease with multifactorial and polygenic etiology, potentially involving arteries and veins of any size resulting in variable vessel vasculitis. We report a case of an Iranian male who presented with porto-sinusoidal vascular disorder due to venous vasculitis as initial manifestation of BD. Despite immunosuppression, anticoagulation and venous recanalization, he subsequently developed severe nephrotic-range proteinuria mimicking a primary renal disease which was completely and immediately ameliorated by stenting of the vena cava. This demonstrates that the proteinuria was caused by increased intraglomerular pressure due to venous outflow obstruction as a consequence of venous vasculitis. To our knowledge, this is the first report of massive proteinuria caused by venous obstruction of the caval vein in the context of BD. Altogether, this case demonstrates the extensive spectrum of vascular disease in BD., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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24. Changes in Migraine Symptoms after Ischemic Stroke: A Cohort Study.

Author: van der Weerd N, Pelzer N, Egberts E, Mertens M, Bakker W, Linstra KM, van den Maagdenberg AMJM, van Zwet EW, MaassenVanDenBrink A, Terwindt GM, and Wermer MJH
Abstract: Introduction: Migraine symptoms are postulated to improve post-stroke. We aimed to determine post-stroke changes in patients with active migraine pre-stroke and explored the relation with stroke location and stroke-preventive medication use., Methods: Patients with active migraine who had an ischemic stroke were retrieved from three research-cohorts between 2014 and 2021. By an interview, we retrospectively investigated first-year post-stroke changes for those ischemic stroke patients that suffered from migraine pre-stroke. Associations between change in migraine frequency/intensity/aura (decrease, no change, increase), stroke location (posterior location vs. other), and use of secondary stroke preventive medication were assessed by ordinal regression with adjustment for confounders., Results: We included 78 patients (mean age 48 years, 86% women, 47% with aura). Change in migraine symptomatology was reported by 63 (81%) patients; 51 (81%) noticed a decrease in attack frequency (27 no attacks) and 12 (19%) an increase. Pain intensity change was reported by 18 (35%) patients (50% increase, 50% decrease). Aura symptomatology improved in 4 (11%). Reduced attack frequency was not related to posterior stroke (OR = 1.5, 95% CI: 0.6-3.9), or preventive medication (antiplatelets OR = 1.0, 95% CI: 0.2-3.7; coumarin OR = 2.7, 95% CI: 0.4-20.6)., Conclusions: Most patients with active pre-stroke migraine experience improvement of their symptoms in the first year after ischemic stroke. This change does not seem to be related to secondary stroke preventive medication or posterior stroke location., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Published: 2024
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25. Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.

Author: Koemans EA, Rasing I, Voigt S, van Harten TW, van der Zwet RGJ, Kaushik K, Schipper MR, van der Weerd N, van Zwet EW, van Etten ES, van Osch MJP, Kuiperij B, Verbeek MM, Terwindt GM, Greenberg SM, van Walderveen MAA, and Wermer MJH
Subjects: Humans, Female, Middle Aged, Adult, Male, Cross-Sectional Studies, Magnetic Resonance Imaging methods, Cerebral Hemorrhage, Biomarkers, Cerebral Amyloid Angiopathy, Familial diagnostic imaging, Cerebral Amyloid Angiopathy diagnostic imaging
Abstract: Background: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. We investigated the presence and abnormality of the most common biomarkers in the largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date., Methods: We included cross-sectional data from participants with (pre)symptomatic D-CAA and controls without CAA. We investigated CAA-related cerebral small vessel disease markers on 3T-MRI, cerebrovascular reactivity with functional 7T-MRI (fMRI) and amyloid-β 40 and amyloid-β 42 levels in cerebrospinal fluid. We calculated frequencies and plotted biomarker abnormality according to age to form scatterplots., Results: We included 68 participants with D-CAA (59% presymptomatic, mean age, 50 [range, 26-75] years; 53% women), 53 controls (mean age, 51 years; 42% women) for cerebrospinal fluid analysis and 36 controls (mean age, 53 years; 100% women) for fMRI analysis. Decreased cerebrospinal fluid amyloid-β 40 and amyloid-β 42 levels were the earliest biomarkers present: all D-CAA participants had lower levels of amyloid-β 40 and amyloid-β 42 compared with controls (youngest participant 30 years). Markers of nonhemorrhagic injury (>20 enlarged perivascular spaces in the centrum semiovale and white matter hyperintensities Fazekas score, ≥2, present in 83% [n=54]) and markers of impaired cerebrovascular reactivity (abnormal BOLD amplitude, time to peak and time to baseline, present in 56% [n=38]) were present from the age of 30 years. Finally, markers of hemorrhagic injury were present in 64% (n=41) and only appeared after the age of 41 years (first microbleeds and macrobleeds followed by cortical superficial siderosis)., Conclusions: Our results suggest that amyloid biomarkers in cerebrospinal fluid are the first to become abnormal in CAA, followed by MRI biomarkers for cerebrovascular reactivity and nonhemorrhagic injury and lastly hemorrhagic injury. This temporal ordering probably reflects the pathological stages of CAA and should be taken into account when future therapeutic trials targeting specific stages are designed., Competing Interests: Disclosures Dr van der Zwet and M. R. Schipper report support from the TRACK D-CAA consortium (Alnylam, Biogen, the Dutch CAA foundation, Vereniging HCHWA-D, researchers from Leiden, Boston, Perth). Dr van Osch reports support by a Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)-VICI grant (016.160.351) and a NWO-Human Measurement Models 2.0 grant (18969), European Community, the Dutch Heart Foundation, the Dutch Brain Foundation VSNU Netherlands and the TRACK D-CAA consortium. Dr Verbeek reports independent support from ZonMw (09120012110098, 10510032120006, and 10510032120003), the Galen and Hilary Weston Foundation (NR170024), Maag-Lever-Darm Stichting (21-05), Parkinson NL (P2021-18), Stichting Alkemade-Keuls, National Institutes of Health (5R01NS104147). Dr Terwindt reports independent support from de NWO, European Community, the Dutch Heart Foundation, the Dutch Brain Foundation, and the Dutch CAA foundation, compensation from Teva Pharmaceutical Industries, H. Lundbeck A S, Novartis Pharma, and Eli Lilly and Company for consultant services. Dr Greenberg reports independent support from the US National Institutes of Health. Dr Wermer independent support from the NWO ZonMw (VIDI grant 91717337), the Netherlands Heart Foundation (2016T86). The other authors report no conflicts.
Published: 2024
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26. Acceleration of GABA-switch after early life stress changes mouse prefrontal glutamatergic transmission.

Author: Karst H, Droogers WJ, van der Weerd N, Damsteegt R, van Kronenburg N, Sarabdjitsingh RA, and Joëls M
Subjects: Animals, Mice, Acceleration, Chlorides metabolism, gamma-Aminobutyric Acid metabolism, Membrane Transport Proteins, Receptors, GABA-A metabolism, Symporters metabolism, Stress, Physiological
Abstract: Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in various rodent brain areas and may be responsible for behavioral impairment later in life. The EI-balance is (amongst others) influenced by the switch of GABAergic transmission from excitatory to inhibitory, the so-called "GABA-switch". Here, we investigated how ELS affects the GABA-switch in mouse infralimbic Prefrontal Cortex layer 2/3 neurons, using the limited-nesting-and-bedding model. In ELS mice, the GABA-switch occurred already between postnatal day (P) 6 and P9, as opposed to P15-P21 in controls. This was associated with increased expression of the inward chloride transporter NKCC1, compared to the outward chloride transporter KCC2, both of which are important for the intracellular chloride concentration and, hence, the GABA reversal potential (Erev). Chloride transporters are not only important for regulating chloride concentration postsynaptically, but also presynaptically. Depending on the Erev of GABA, presynaptic GABA A receptor stimulation causes a depolarization or hyperpolarization, and thereby enhanced or reduced fusion of glutamate vesicles respectively, in turn changing the frequency of miniature postsynaptic currents (mEPSCs). In accordance, bumetanide, a blocker of NKCC1, shifted the Erev GABA towards more hyperpolarized levels in P9 control mice and reduced the mEPSC frequency. Other modulators of chloride transporters, e.g. VU0463271 (a KCC2 antagonist) and aldosterone -which increases NKCC1 expression-did not affect postsynaptic Erev in ELS P9 mice, but did increase the mEPSC frequency. We conclude that the mouse GABA-switch is accelerated after ELS, affecting both the pre- and postsynaptic chloride homeostasis, the former altering glutamatergic transmission. This may considerably affect brain development., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Published: 2023
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27. Subarachnoid CSF hyperintensities at 7 tesla FLAIR MRI: A novel marker in cerebral amyloid angiopathy.

Author: Koemans EA, van Walderveen MAA, Voigt S, Rasing I, van Harten TW, J A van Os H, van der Weerd N, Terwindt GM, van Osch MJP, van Veluw SJ, Freeze WM, and Wermer MJH
Subjects: Female, Humans, Aged, Middle Aged, Retrospective Studies, Prospective Studies, Magnetic Resonance Imaging, Cerebral Amyloid Angiopathy diagnostic imaging, Stroke complications, Siderosis complications
Abstract: Background: We observed subarachnoid cerebrospinal fluid (CSF) hyperintensities at non-contrast 7-tesla (T) fluid-attenuated inversion recovery (FLAIR) MRI, frequently topographically associated with cortical superficial siderosis (cSS), in participants with cerebral amyloid angiopathy (CAA). To systemically evaluate these CSF hyperintensities we investigated their frequency and anatomical and temporal relationship with cSS on 7T and 3T MRI in hereditary Dutch-type CAA (D-CAA), sporadic CAA (sCAA), and non-CAA controls., Methods: CAA participants were included from two prospective natural history studies and non-CAA controls from a 7T study in healthy females and females with ischemic stroke. CSF hyperintensities were scored by two independent observers., Results: We included 38 sCAA participants (mean age 72y), 50 D-CAA participants (mean age 50y) and 44 non-CAA controls (mean age 53y, 15 with stroke). In total 27/38 (71 %, 95 %CI 56-84) sCAA and 23/50 (46 %, 95 %CI 33-60) D-CAA participants had subarachnoid CSF hyperintensities at baseline 7T. Most (96 %) of those had cSS, in 54 % there was complete topographical overlap with cSS. The remaining 46 % had ≥1 sulcus with CSF hyperintensities without co-localizing cSS. None of the healthy controls and 2/15 (13 %, 95 %CI 2-41, 100 % cSS overlap) of the stroke controls had CSF hyperintensities. In 85 % of the CAA participants CSF hyperintensities could retrospectively be identified at 3T. Of the 35 CAA participants with follow-up 7T after two years, 17/35 (49 %) showed increase and 6/35 (17 %) decrease of regional CSF hyperintensities. In 2/11 (18 %) of participants with follow-up who had baseline CSF hyperintensities without overlapping cSS, new cSS developed at those locations., Conclusions: Subarachnoid CSF hyperintensities at 7T FLAIR MRI occur frequently in CAA and are associated with cSS, although without complete overlap. We hypothesize that the phenomenon could be a sign of subtle plasma protein or blood product leakage into the CSF, resulting in CSF T1-shortening., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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28. Sex Differences in Presentation of Stroke: A Systematic Review and Meta-Analysis.

Author: Ali M, van Os HJA, van der Weerd N, Schoones JW, Heymans MW, Kruyt ND, Visser MC, and Wermer MJH
Subjects: Cohort Studies, Cross-Sectional Studies, Diagnostic Errors, Female, Humans, Intracranial Hemorrhages complications, Ischemic Attack, Transient diagnosis, Male, Sex Characteristics, Treatment Outcome, Stroke diagnosis
Abstract: Background and Purpose: Women have worse outcomes than men after stroke. Differences in presentation may lead to misdiagnosis and, in part, explain these disparities. We investigated whether there are sex differences in clinical presentation of acute stroke or transient ischemic attack., Methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Inclusion criteria were (1) cohort, cross-sectional, case-control, or randomized controlled trial design; (2) admission for (suspicion of) ischemic or hemorrhagic stroke or transient ischemic attack; and (3) comparisons possible between sexes in ≥1 nonfocal or focal acute stroke symptom(s). A random-effects model was used for our analyses. We performed sensitivity and subanalyses to help explain heterogeneity and used the Newcastle-Ottawa Scale to assess bias., Results: We included 60 studies (n=582 844; 50% women). In women, headache (pooled odds ratio [OR], 1.24 [95% CI, 1.11-1.39]; I 2 =75.2%; 30 studies) occurred more frequently than in men with any type of stroke, as well as changes in consciousness/mental status (OR, 1.38 [95% CI, 1.19-1.61]; I 2 =95.0%; 17 studies) and coma/stupor (OR, 1.39 [95% CI, 1.25-1.55]; I 2 =27.0%; 13 studies). Aspecific or other neurological symptoms (nonrotatory dizziness and non-neurological symptoms) occurred less frequently in women (OR, 0.96 [95% CI, 0.94-0.97]; I 2 =0.1%; 5 studies). Overall, the presence of focal symptoms was not associated with sex (pooled OR, 1.03) although dysarthria (OR, 1.14 [95% CI, 1.04-1.24]; I 2 =48.6%; 11 studies) and vertigo (OR, 1.23 [95% CI, 1.13-1.34]; I 2 =44.0%; 8 studies) occurred more frequently, whereas symptoms of paresis/hemiparesis (OR, 0.73 [95% CI, 0.54-0.97]; I 2 =72.6%; 7 studies) and focal visual disturbances (OR, 0.83 [95% CI, 0.70-0.99]; I 2 =62.8%; 16 studies) occurred less frequently in women compared with men with any type of stroke. Most studies contained possible sources of bias., Conclusions: There may be substantive differences in nonfocal and focal stroke symptoms between men and women presenting with acute stroke or transient ischemic attack, but sufficiently high-quality studies are lacking. More studies are needed to address this because sex differences in presentation may lead to misdiagnosis and undertreatment.
Published: 2022
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29. Sex Differences in Hemostatic Factors in Patients With Ischemic Stroke and the Relation With Migraine-A Systematic Review.

Author: van der Weerd N, van Os HJA, Ali M, Schoones JW, van den Maagdenberg AMJM, Kruyt ND, Siegerink B, and Wermer MJH
Abstract: Background: Women are more affected by stroke than men. This might, in part, be explained by sex differences in stroke pathophysiology. The hemostasis system is influenced by sex hormones and associated with female risk factors for stroke, such as migraine. Aim: To systematically review possible sex differences in hemostatic related factors in patients with ischemic stroke in general, and the influence of migraine on these factors in women with ischemic stroke. Results: We included 24 studies with data on sex differences of hemostatic factors in 7247 patients with ischemic stroke (mean age 57-72 years, 27-57% women) and 25 hemostatic related factors. Levels of several factors were higher in women compared with men; FVII:C (116% ± 30% vs. 104% ± 30%), FXI (0.14 UI/mL higher in women), PAI-1 (125.35 ± 49.37 vs. 96.67 ± 38.90 ng/mL), D-dimer (1.25 ± 0.31 vs. 0.95 ± 0.24 μg/mL), and aPS (18.7% vs. 12.0% positive). In contrast, protein-S (86.2% ± 23.0% vs. 104.7% ± 19.8% antigen) and P-selectin (48.9 ± 14.4 vs. 79.1 ± 66.7 pg/mL) were higher in men. Most factors were investigated in single studies, at different time points after stroke, and in different stroke subtypes. Only one small study reported data on migraine and hemostatic factors in women with ischemic stroke. No differences in fibrinogen, D-dimer, t-PA, and PAI-1 levels were found between women with and without migraine. Conclusion: Our systematic review suggests that sex differences exist in the activation of the hemostatic system in ischemic stroke. Women seem to lean more toward increased levels of procoagulant factors whereas men exhibit increased levels of coagulation inhibitors. To obtain better insight in sex-related differences in hemostatic factors, additional studies are needed to confirm these findings with special attention for different stroke phases, stroke subtypes, and not in the least women specific risk factors, such as migraine., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 van der Weerd, van Os, Ali, Schoones, van den Maagdenberg, Kruyt, Siegerink and Wermer.)
Published: 2021
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30. Age-dependent shift in spontaneous excitation-inhibition balance of infralimbic prefrontal layer II/III neurons is accelerated by early life stress, independent of forebrain mineralocorticoid receptor expression.

Author: Karst H, Sarabdjitsingh RA, van der Weerd N, Feenstra E, Damsteegt R, and Joëls M
Subjects: Age Factors, Animals, Animals, Newborn, Female, Gene Expression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons metabolism, Prefrontal Cortex pathology, Prosencephalon pathology, Receptors, Mineralocorticoid genetics, Stress, Psychological pathology, Stress, Psychological prevention & control, Excitatory Postsynaptic Potentials physiology, Inhibitory Postsynaptic Potentials physiology, Prefrontal Cortex metabolism, Prosencephalon metabolism, Receptors, Mineralocorticoid biosynthesis, Stress, Psychological metabolism
Abstract: In this study we tested the hypothesis i) that age-dependent shifts in the excitation-inhibition balance of prefrontal neurons are accelerated by early life stress, a risk factor for the etiology of many psychiatric disorders; and if so, ii) that this process is exacerbated by genetic forebrain-specific downregulation of the mineralocorticoid receptor, a receptor that was earlier found to be a protective factor for negative effects of early life stress in both rodents and humans. In agreement with the literature, an age-dependent downregulation of the excitation-inhibition balance was found both with regard to spontaneous and evoked synaptic currents. The age-dependent shift in spontaneous excitatory relative to inhibitory currents was significantly accelerated by early life stress, but this was not exacerbated by reduction in mineralocorticoid receptor expression. The age-dependent changes in the excitation-inhibition balance were mirrored by similar changes in receptor subunit expression and morphological alterations, particularly in spine density, which could thus potentially contribute to the functional changes. However, none of these parameters displayed acceleration by early life stress, nor depended on mineralocorticoid receptor expression. We conclude that, in agreement with the hypothesis, early life stress accelerates the developmental shift of the excitation-inhibition balance but, contrary to expectation, there is no evidence for a putative protective role of the mineralocorticoid receptor in this system. In view of the modest effect of early life stress on the excitation-inhibition balance, alternative mechanisms potentially underlying the development of psychiatric disorders should be further explored., (Copyright © 2020. Published by Elsevier Ltd.)
Published: 2020
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31. Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant.

Author: Kamburova EG, Wisse BW, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Seelen MAJ, Sanders JSF, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens M, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KA, van der Weerd NC, Ten Berge IJM, Bemelman FJ, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, and Otten HG
Subjects: Adult, Cadaver, Female, Follow-Up Studies, Graft Rejection etiology, Graft Rejection pathology, Graft Survival, Humans, Kidney Transplantation adverse effects, Male, Middle Aged, Postoperative Complications, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Donor Selection, Graft Rejection mortality, HLA Antigens immunology, Isoantibodies adverse effects, Kidney Failure, Chronic surgery, Kidney Transplantation mortality, Living Donors
Abstract: The presence of donor-specific anti-HLA antibodies (DSAs) is associated with increased risk of graft failure after kidney transplant. We hypothesized that DSAs against HLA class I, class II, or both classes indicate a different risk for graft loss between deceased and living donor transplant. In this study, we investigated the impact of pretransplant DSAs, by using single antigen bead assays, on long-term graft survival in 3237 deceased and 1487 living donor kidney transplants with a negative complement-dependent crossmatch. In living donor transplants, we found a limited effect on graft survival of DSAs against class I or II antigens after transplant. Class I and II DSAs combined resulted in decreased 10-year graft survival (84% to 75%). In contrast, after deceased donor transplant, patients with class I or class II DSAs had a 10-year graft survival of 59% and 60%, respectively, both significantly lower than the survival for patients without DSAs (76%). The combination of class I and II DSAs resulted in a 10-year survival of 54% in deceased donor transplants. In conclusion, class I and II DSAs are a clear risk factor for graft loss in deceased donor transplants, while in living donor transplants, class I and II DSAs seem to be associated with an increased risk for graft failure, but this could not be assessed due to their low prevalence., (© 2018 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)
Published: 2018
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32. Hepcidin in chronic kidney disease: not an anaemia management tool, but promising as a cardiovascular biomarker.

Author: van der Weerd NC, Grooteman MP, Nubé MJ, ter Wee PM, Swinkels DW, and Gaillard CA
Subjects: Anemia, Biomarkers, Humans, Cardiovascular Diseases metabolism, Disease Management, Hepcidins metabolism, Renal Insufficiency, Chronic metabolism
Abstract: Hepcidin is a key regulator of iron homeostasis and plays a role in the pathogenesis of anaemia of chronic disease. Its levels are increased in patients with chronic kidney disease (CKD) due to diminished renal clearance and an inflammatory state. Increased hepcidin levels in CKD patients are supposed to be responsible for functional iron deficiency in these patients and contribute to renal anaemia and resistance to erythropoiesis-stimulating agents. Therefore, hepcidin was purported to be useful as a management tool guiding treatment of renal anaemia. Furthermore, since hepcidin is associated with iron accumulation in macrophages in the vessel wall inducing oxidative stress and atherosclerosis, it has been speculated that hepcidin might function as a biomarker of cardiovascular disease. In this descriptive review, the merits of hepcidin with respect to its role in the pathophysiology of renal anaemia in CKD patients, its presumptive role as a practical diagnostic tool guiding management of renal anaemia, and its possible usefulness as a prognostic biomarker will be discussed.
Published: 2015

33. The PROCARE consortium: toward an improved allocation strategy for kidney allografts.

Author: Otten HG, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas M, Spierings E, Hack CE, van Reekum F, van Zuilen AD, Verhaar MC, Bots ML, Seelen MA, Sanders JS, Hepkema BG, Lambeck AJ, Bungener LB, Roozendaal C, Tilanus MG, Vanderlocht J, Voorter CE, Wieten L, van Duijnhoven E, Gelens M, Christiaans M, van Ittersum F, Nurmohamed A, Lardy NM, Swelsen WT, van Donselaar-van der Pant KA, van der Weerd NC, Ten Berge IJ, Bemelman FJ, Hoitsma AJ, de Fijter JW, Betjes MG, Roelen DL, and Claas FH
Subjects: Epitopes, B-Lymphocyte immunology, Epitopes, T-Lymphocyte immunology, Graft Rejection immunology, Graft Survival immunology, HLA Antigens immunology, Humans, Kidney immunology, Kidney surgery, Quality of Life, Renal Dialysis, Histocompatibility Testing methods, Kidney Failure, Chronic surgery, Kidney Transplantation mortality, Tissue and Organ Procurement methods, Waiting Lists
Abstract: Kidney transplantation is the best treatment option for patients with end-stage renal failure. At present, approximately 800 Dutch patients are registered on the active waiting list of Eurotransplant. The waiting time in the Netherlands for a kidney from a deceased donor is on average between 3 and 4 years. During this period, patients are fully dependent on dialysis, which replaces only partly the renal function, whereas the quality of life is limited. Mortality among patients on the waiting list is high. In order to increase the number of kidney donors, several initiatives have been undertaken by the Dutch Kidney Foundation including national calls for donor registration and providing information on organ donation and kidney transplantation. The aim of the national PROCARE consortium is to develop improved matching algorithms that will lead to a prolonged survival of transplanted donor kidneys and a reduced HLA immunization. The latter will positively affect the waiting time for a retransplantation. The present algorithm for allocation is among others based on matching for HLA antigens, which were originally defined by antibodies using serological typing techniques. However, several studies suggest that this algorithm needs adaptation and that other immune parameters which are currently not included may assist in improving graft survival rates. We will employ a multicenter-based evaluation on 5429 patients transplanted between 1995 and 2005 in the Netherlands. The association between key clinical endpoints and selected laboratory defined parameters will be examined, including Luminex-defined HLA antibody specificities, T and B cell epitopes recognized on the mismatched HLA antigens, non-HLA antibodies, and also polymorphisms in complement and Fc receptors functionally associated with effector functions of anti-graft antibodies. From these data, key parameters determining the success of kidney transplantation will be identified which will lead to the identification of additional parameters to be included in future matching algorithms aiming to extend survival of transplanted kidneys and to diminish HLA immunization. Computer simulation studies will reveal the number of patients having a direct benefit from improved matching, the effect on shortening of the waiting list, and the decrease in waiting time., (Copyright © 2014. Published by Elsevier B.V.)
Published: 2014
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34. [Decreasing prevalence of Helicobacter pylori: a consequence of treatment of gastroduodenal ulcers].

Author: van der Weerd NC, Cats A, Thijs JC, Festen HP, Meuwissen SG, and Kuipers EJ
Subjects: Adult, Aged, Crohn Disease complications, Diagnosis, Differential, Female, Helicobacter Infections drug therapy, Helicobacter Infections microbiology, Humans, Male, Melena etiology, Netherlands epidemiology, Peptic Ulcer drug therapy, Peptic Ulcer etiology, Peptic Ulcer microbiology, Prevalence, Recurrence, Zollinger-Ellison Syndrome complications, Crohn Disease diagnosis, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification, Peptic Ulcer diagnosis, Peptic Ulcer epidemiology, Zollinger-Ellison Syndrome diagnosis
Abstract: Four patients with gastroduodenal ulcers in the absence of Helicobacter pylori illustrate the decreasing prevalence of this microorganism. One was a 19-year-old boy with nausea, diarrhoea and weight loss caused by multiple gastroduodenal ulcers due to the Zollinger-Ellison syndrome. Another was a 36-year-old man with abdominal discomfort caused by an ulcer due to Crohn's disease. The other two cases concerned a 29-year-old man and a 68-year-old woman with relapsing ulcer disease and active bleeding, in whom no causal factors could be determined. Recent studies suggest a decreasing prevalence of H. pylori leading to both a relative and an absolute decrease of gastroduodenal ulcers attributed to H. pylori. Future treatment strategies will have to take these altered prevalence rates into consideration.
Published: 2000

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34 results on '"van der Weerd N"'

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34. [Decreasing prevalence of Helicobacter pylori: a consequence of treatment of gastroduodenal ulcers].

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