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3. Wall shear stress-related plaque growth of lipid-rich plaques in human coronary arteries:an near-infrared spectroscopy and optical coherence tomography study

Author

Hartman, Eline M J, De Nisco, Giuseppe, Kok, Annette M, Tomaniak, Mariusz, Nous, Fay M A, Korteland, Suze-Anne, Gijsen, Frank J H, den Dekker, Wijnand K, Diletti, Roberto, van Mieghem, Nicolas M D A, Wilschut, Jeroen M, Zijlstra, Felix, van der Steen, Anton F W, Budde, Ricardo P J, Daemen, Joost, Wentzel, Jolanda J, Hartman, Eline M J, De Nisco, Giuseppe, Kok, Annette M, Tomaniak, Mariusz, Nous, Fay M A, Korteland, Suze-Anne, Gijsen, Frank J H, den Dekker, Wijnand K, Diletti, Roberto, van Mieghem, Nicolas M D A, Wilschut, Jeroen M, Zijlstra, Felix, van der Steen, Anton F W, Budde, Ricardo P J, Daemen, Joost, and Wentzel, Jolanda J

Abstract

AIMS: Low wall shear stress (WSS) is acknowledged to play a role in plaque development through its influence on local endothelial function. Also, lipid-rich plaques (LRPs) are associated with endothelial dysfunction. However, little is known about the interplay between WSS and the presence of lipids with respect to plaque progression. Therefore, we aimed to study the differences in WSS-related plaque progression between LRPs, non-LRPs, or plaque-free regions in human coronary arteries.METHODS AND RESULTS: In the present single-centre, prospective study, 40 patients who presented with an acute coronary syndrome successfully underwent near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) and optical coherence tomography (OCT) of at least one non-culprit vessel at baseline and completed a 1-year follow-up. WSS was computed applying computational fluid dynamics to a three-dimensional reconstruction of the coronary artery based on the fusion of the IVUS-segmented lumen with a CT-derived centreline, using invasive flow measurements as boundary conditions. For data analysis, each artery was divided into 1.5 mm/45° sectors. Plaque growth based on IVUS-derived percentage atheroma volume change was compared between LRPs, non-LRPs, and plaque-free wall segments, as assessed by both OCT and NIRS. Both NIRS- and OCT-detected lipid-rich sectors showed a significantly higher plaque progression than non-LRPs or plaque-free regions. Exposure to low WSS was associated with a higher plaque progression than exposure to mid or high WSS, even in the regions classified as a plaque-free wall. Furthermore, low WSS and the presence of lipids had a synergistic effect on plaque growth, resulting in the highest plaque progression in lipid-rich regions exposed to low shear stress.CONCLUSION: This study demonstrates that NIRS- and OCT-detected lipid-rich regions exposed to low WSS are subject to enhanced plaque growth over a 1-year follow-up. The presence of lipids and

Published
2023

4. Wall shear stress–related plaque growth of lipid-rich plaques in human coronary arteries: an near-infrared spectroscopy and optical coherence tomography study

Author

Hartman, Eline M J, primary, De Nisco, Giuseppe, additional, Kok, Annette M, additional, Tomaniak, Mariusz, additional, Nous, Fay M A, additional, Korteland, Suze-Anne, additional, Gijsen, Frank J H, additional, den Dekker, Wijnand K, additional, Diletti, Roberto, additional, van Mieghem, Nicolas M D A, additional, Wilschut, Jeroen M, additional, Zijlstra, Felix, additional, van der Steen, Anton F W, additional, Budde, Ricardo P J, additional, Daemen, Joost, additional, and Wentzel, Jolanda J, additional

Published
2022
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5. Visualization of the Vulnerable Plaque

Author

Krams, Rob, Schaar, Johannes, Helderman, Frank, Cheng, Caroline, Gourabi, Babak Mousavi, van Damme, L. C. A., Segers, D., Regar, Evelyn, Slager, Cornelis J., de Feyter, Pim J., van der Steen, Anton F. W., Serruys, Patrick W., Pasterkamp, Gerard, editor, and de Kleijn, Dominique P. V., editor

Published
2006
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9. The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study

Author

Dilba, Kristine, primary, van Dam-Nolen, Dianne H. K., additional, Korteland, Suze-Anne, additional, van der Kolk, Anja G., additional, Kassem, Mohamed, additional, Bos, Daniel, additional, Koudstaal, Peter J., additional, Nederkoorn, Paul J., additional, Hendrikse, Jeroen, additional, Kooi, M. Eline, additional, Gijsen, Frank J. H., additional, van der Steen, Anton F. W., additional, van der Lugt, Aad, additional, and Wentzel, Jolanda J., additional

Published
2021
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10. The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study

Author

Dilba, Kristine, van Dam-Nolen, Dianne H. K., Korteland, Suze-Anne, van der Kolk, Anja G., Kassem, Mohamed, Bos, Daniel, Koudstaal, Peter J., Nederkoorn, Paul J., Hendrikse, Jeroen, Kooi, M. Eline, Gijsen, Frank J. H., van der Steen, Anton F. W., van der Lugt, Aad, Wentzel, Jolanda J., Dilba, Kristine, van Dam-Nolen, Dianne H. K., Korteland, Suze-Anne, van der Kolk, Anja G., Kassem, Mohamed, Bos, Daniel, Koudstaal, Peter J., Nederkoorn, Paul J., Hendrikse, Jeroen, Kooi, M. Eline, Gijsen, Frank J. H., van der Steen, Anton F. W., van der Lugt, Aad, and Wentzel, Jolanda J.

Published
2021

11. The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study

Author

Computational Imaging, Cancer, Divisie Beeld, Researchgr. Neuroradiologie, Brain, Dilba, Kristine, van Dam-Nolen, Dianne H K, Korteland, Suze-Anne, van der Kolk, Anja G, Kassem, Mohamed, Bos, Daniel, Koudstaal, Peter J, Nederkoorn, Paul J, Hendrikse, Jeroen, Kooi, M Eline, Gijsen, Frank J H, van der Steen, Anton F W, van der Lugt, Aad, Wentzel, Jolanda J, Computational Imaging, Cancer, Divisie Beeld, Researchgr. Neuroradiologie, Brain, Dilba, Kristine, van Dam-Nolen, Dianne H K, Korteland, Suze-Anne, van der Kolk, Anja G, Kassem, Mohamed, Bos, Daniel, Koudstaal, Peter J, Nederkoorn, Paul J, Hendrikse, Jeroen, Kooi, M Eline, Gijsen, Frank J H, van der Steen, Anton F W, van der Lugt, Aad, and Wentzel, Jolanda J

Published
2021

12. Association between Intraplaque Hemorrhage and Vascular Remodeling in Carotid Arteries: The Plaque at RISK (PARISK) Study

Author

Brain, Researchgr. Neuroradiologie, MS Radiologie, Dilba, Kristine, van Dijk, Anouk C, Crombag, Geneviève A J C, van der Steen, Anton F W, Daemen, Mat J, Koudstaal, Peter J, Nederkoorn, Paul J, Hendrikse, Jeroen, Kooi, M Eline, van der Lugt, Aad, Wentzel, Jolanda J, Brain, Researchgr. Neuroradiologie, MS Radiologie, Dilba, Kristine, van Dijk, Anouk C, Crombag, Geneviève A J C, van der Steen, Anton F W, Daemen, Mat J, Koudstaal, Peter J, Nederkoorn, Paul J, Hendrikse, Jeroen, Kooi, M Eline, van der Lugt, Aad, and Wentzel, Jolanda J

Published
2021

18. Lipid-rich Plaques Detected by Near-infrared Spectroscopy Are More Frequently Exposed to High Shear Stress

Author

Hartman, Eline M. J., primary, De Nisco, Giuseppe, additional, Kok, Annette M., additional, Hoogendoorn, Ayla, additional, Coenen, Adriaan, additional, Mastik, Frits, additional, Korteland, Suze-Anne, additional, Nieman, Koen, additional, Gijsen, Frank J. H., additional, van der Steen, Anton F. W., additional, Daemen, Joost, additional, and Wentzel, Jolanda J., additional

Published
2020
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21. No Association between Thrombin Generation and Intra-Plaque Haemorrhage in Symptomatic Carotid Atherosclerotic Plaques: The Plaque at RISK (PARISK) Study

Author

Crombag, Genevieve A. J. C., Crombag, Genevieve A. J. C., Spronk, Henri M., Nelemans, Patty, Schreuder, Floris H. B. M., Truijman, Martine T. B., van Dijk, Anouk C., de Rotte, Alexandra A. J., Liem, Madieke I., Daemen, Mat J. A. P., van der Steen, Anton F. W., Mess, Werner H., Nederkoorn, Paul J., Hendrikse, Jeroen, van der Lugt, Aad, Wildberger, Joachim E., ten Cate, Hugo, van Oostenbrugge, Robert J., Kooi, M. Eline, Crombag, Genevieve A. J. C., Crombag, Genevieve A. J. C., Spronk, Henri M., Nelemans, Patty, Schreuder, Floris H. B. M., Truijman, Martine T. B., van Dijk, Anouk C., de Rotte, Alexandra A. J., Liem, Madieke I., Daemen, Mat J. A. P., van der Steen, Anton F. W., Mess, Werner H., Nederkoorn, Paul J., Hendrikse, Jeroen, van der Lugt, Aad, Wildberger, Joachim E., ten Cate, Hugo, van Oostenbrugge, Robert J., and Kooi, M. Eline

Abstract

Background Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the relation between thrombin and plaque vulnerability. We hypothesize that decreased thrombin generation (TG) is associated with IPH and plaque vulnerability. Objective This article investigates whether TG is associated with IPH and other features of plaque vulnerability in stroke patients. Methods Recently symptomatic stroke patients underwent carotid MRI and blood sampling. MRI plaque features include plaque burden, presence of IPH, amount of lipid-rich necrotic core (LRNC), calcified tissue and fibrous tissue (% of total wall volume). TG was assessed in platelet-poor plasma and expressed as: peak height (PH) and endogenous thrombin potential (ETP). MR images could be analysed in 224 patients. Blood samples were available in 161 of 224 patients. Binary multivariate logistic and linear regression were used to investigate the association between TG and MRI plaque features. Results IPH and LRNC were present in 65 (40%) and 102 (63%) of plaques. There were no significant associations between TG and IPH; PH odds ratio (OR)=1, 95% confidence interval (CI): 0.76 to 1.45 and ETP OR=1, 95% CI: 0.73 to 1.37. After correction for age, sex and hypercholesterolaemia, the association was weak but non-significant; PH: OR=0.76, 95% CI: 0.52 to 1.10 and ETP: OR=0.73, 95% CI: 0.53 to 1.37. Conclusion Features of carotid plaque on MRI show no significant association with TG in stroke patients. Systemic TG does not seem to be an important factor in IPH development.

Published
2018

23. Use of Antiplatelet Agents Is Associated With Intraplaque Hemorrhage on Carotid Magnetic Resonance Imaging : The Plaque at Risk Study

Author

Liem, Madieke I, Schreuder, Floris H B M, van Dijk, Anouk C, de Rotte, Alexandra A J, Truijman, Martine T B, Daemen, Mat J A P, van der Steen, Anton F W, Hendrikse, J, Nederveen, Aart J, van der Lugt, Aad, Kooi, M Eline, Nederkoorn, Paul J, Liem, Madieke I, Schreuder, Floris H B M, van Dijk, Anouk C, de Rotte, Alexandra A J, Truijman, Martine T B, Daemen, Mat J A P, van der Steen, Anton F W, Hendrikse, J, Nederveen, Aart J, van der Lugt, Aad, Kooi, M Eline, and Nederkoorn, Paul J

Published
2015

24. Plaque Components in Symptomatic Moderately Stenosed Carotid Arteries Related to Cerebral Infarcts The Plaque At RISK Study

Author

de Rotte, Alexandra A. J., Truijman, Martine T. B., van Dijk, Anouk C., Liem, Madieke I., Schreuder, Floris H. B. M., van der Kolk, Anja G., de Kruijk, Jelle R., Daemen, Matt J. A. P., van der Steen, Anton F. W., de Borst, Gert Jan, Luijten, Peter R., Nederkoorn, Paul J., Kooi, Marianne Eline, van der Lugt, Aad, Hendrikse, J, de Rotte, Alexandra A. J., Truijman, Martine T. B., van Dijk, Anouk C., Liem, Madieke I., Schreuder, Floris H. B. M., van der Kolk, Anja G., de Kruijk, Jelle R., Daemen, Matt J. A. P., van der Steen, Anton F. W., de Borst, Gert Jan, Luijten, Peter R., Nederkoorn, Paul J., Kooi, Marianne Eline, van der Lugt, Aad, and Hendrikse, J

Published
2015

25. Use of Antiplatelet Agents Is Associated With Intraplaque Hemorrhage on Carotid Magnetic Resonance Imaging: The Plaque at Risk Study

Author

RF&S Team 2 Medisch, Circulatory Health, MS Radiologie, Liem, Madieke I, Schreuder, Floris H B M, van Dijk, Anouk C, de Rotte, Alexandra A J, Truijman, Martine T B, Daemen, Mat J A P, van der Steen, Anton F W, Hendrikse, J, Nederveen, Aart J, van der Lugt, Aad, Kooi, M Eline, Nederkoorn, Paul J, RF&S Team 2 Medisch, Circulatory Health, MS Radiologie, Liem, Madieke I, Schreuder, Floris H B M, van Dijk, Anouk C, de Rotte, Alexandra A J, Truijman, Martine T B, Daemen, Mat J A P, van der Steen, Anton F W, Hendrikse, J, Nederveen, Aart J, van der Lugt, Aad, Kooi, M Eline, and Nederkoorn, Paul J

Published
2015

26. Plaque Components in Symptomatic Moderately Stenosed Carotid Arteries Related to Cerebral Infarcts The Plaque At RISK Study

Author

RF&S Team 2 Medisch, Circulatory Health, Radiologie, Zorgeenheid Vaatchirurgie Medisch, Highfield Research Group, Cancer, MS Radiologie, de Rotte, Alexandra A. J., Truijman, Martine T. B., van Dijk, Anouk C., Liem, Madieke I., Schreuder, Floris H. B. M., van der Kolk, Anja G., de Kruijk, Jelle R., Daemen, Matt J. A. P., van der Steen, Anton F. W., de Borst, Gert Jan, Luijten, Peter R., Nederkoorn, Paul J., Kooi, Marianne Eline, van der Lugt, Aad, Hendrikse, J, RF&S Team 2 Medisch, Circulatory Health, Radiologie, Zorgeenheid Vaatchirurgie Medisch, Highfield Research Group, Cancer, MS Radiologie, de Rotte, Alexandra A. J., Truijman, Martine T. B., van Dijk, Anouk C., Liem, Madieke I., Schreuder, Floris H. B. M., van der Kolk, Anja G., de Kruijk, Jelle R., Daemen, Matt J. A. P., van der Steen, Anton F. W., de Borst, Gert Jan, Luijten, Peter R., Nederkoorn, Paul J., Kooi, Marianne Eline, van der Lugt, Aad, and Hendrikse, J

Published
2015

30. Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging

Author

Harvard University--MIT Division of Health Sciences and Technology, Bouma, Brett E., Tearney, Guillermo J., Oosterhuis, J. Wolter, Okamura, Takayuki, van Noorden, Sander, Gonzalo, Nieves, van Leenders, Geert L. J. H., Koljenović, Senada, van der Steen, Anton F. W., Serruys, Patrick W., Regar, Evelyn, Goderie, Thadé, van Soest, Gijs, Harvard University--MIT Division of Health Sciences and Technology, Bouma, Brett E., Tearney, Guillermo J., Oosterhuis, J. Wolter, Okamura, Takayuki, van Noorden, Sander, Gonzalo, Nieves, van Leenders, Geert L. J. H., Koljenović, Senada, van der Steen, Anton F. W., Serruys, Patrick W., Regar, Evelyn, Goderie, Thadé, and van Soest, Gijs

Abstract

Optical coherence tomography (OCT) is rapidly becoming the method of choice for assessing arterial wall pathology in vivo. Atherosclerotic plaques can be diagnosed with high accuracy, including measurement of the thickness of fibrous caps, enabling an assessment of the risk of rupture. While the OCT image presents morphological information in highly resolved detail, it relies on interpretation of the images by trained readers for the identification of vessel wall components and tissue type. We present a framework to enable systematic and automatic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient µt of the tissue. OCT images of 65 coronary artery segments in vitro, obtained from 14 vessels harvested at autopsy, are analyzed and correlated with histology. Vessel wall components can be distinguished based on their optical properties: necrotic core and macrophage infiltration exhibit strong attenuation, µt>=10 mm−1, while calcific and fibrous tissue have a lower µt[approximate]2−5mm−1. The algorithm is successfully applied to OCT patient data, demonstrating that the analysis can be used in a clinical setting and assist diagnostics of vessel wall pathology.

Published
2010

41. Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging

Author

van Soest, Gijs, primary, Goderie, Thadé, additional, Regar, Evelyn, additional, Koljenović, Senada, additional, van Leenders, Geert L. J. H., additional, Gonzalo, Nieves, additional, van Noorden, Sander, additional, Okamura, Takayuki, additional, Bouma, Brett E., additional, Tearney, Guillermo J., additional, Oosterhuis, J. Wolter, additional, Serruys, Patrick W., additional, and van der Steen, Anton F. W., additional

Published
2010
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43. Strain distribution over plaques in human coronary arteries relates to shear stress

Author

Gijsen, Frank J. H., primary, Wentzel, Jolanda J., additional, Thury, Attila, additional, Mastik, Frits, additional, Schaar, Johannes A., additional, Schuurbiers, Johan C. H., additional, Slager, Cornelis J., additional, van der Giessen, Wim J., additional, de Feyter, Pim J., additional, van der Steen, Anton F. W., additional, and Serruys, Patrick W., additional

Published
2008
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48. Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique

Author

Cheng, Caroline, primary, van Haperen, Rien, additional, de Waard, Monique, additional, van Damme, Luc C. A., additional, Tempel, Dennie, additional, Hanemaaijer, Laurens, additional, van Cappellen, Gert W. A., additional, Bos, Joop, additional, Slager, Cornelis J., additional, Duncker, Dirk J., additional, van der Steen, Anton F. W., additional, de Crom, Rini, additional, and Krams, Rob, additional

Published
2005
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