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106 results on '"van der Spek R"'

1. Orthopädie

Author

Tannheimer M, Angelini C, Faulhaber M, Hillebrandt D, Szygula Z, Ulmer HV, Usaj A, van der Spek R, and Küpper T

Subjects
Sports medicine, RC1200-1245
Published
2015
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3. GRB 010921: Discovery of the First HETE Afterglow

Author

Price, P. A., Kulkarni, S. R., Berger, E., Djorgovski, S. G., Frail, D. A., Mahabal, A., Fox, D. W., Harrison, F. A., Bloom, J. S., Yost, S. A., Reichart, D. E., Henden, A. A., Ricker, G. R., van der Spek, R., Hurley, K., Atteia, J. -L., Kawai, N., Fenimore, E., and Graziani, C.

Subjects
Astrophysics
Abstract

We report the discovery of the optical and radio afterglow of GRB 010921, the first gamma-ray burst afterglow to be found from a localization by the High Energy Transient Explorer (HETE) satellite. We present optical spectroscopy of the host galaxy which we find to be a dusty and apparently normal star-forming galaxy at z = 0.451. The unusually steep optical spectral slope of the afterglow can be explained by heavy extinction, A_V > 0.5 mag, along the line of sight to the GRB. Dust with similar A_V for the the host galaxy as a whole appears to be required by the measurement of a Balmer decrement in the spectrum of the host galaxy. Thanks to the low redshift, continued observations of the afterglow will enable the strongest constraints, to date, on the existence of a possible underlying supernova., Comment: 16 pages, 3 figures. Submitted to the Astrophsical Journal Letters

Published
2002
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16. Carrhae

Author

Gray, Eric William, Sherwin-White, Susan Mary, and van der Spek, R. J.

Published
2015
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24. Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (Nature Genetics, (2021), 53, 12, (1636-1648), 10.1038/s41588-021-00973-1)

Author

van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H. -J., Bakker, O. B., Deelen, P., Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., Dolzhenko, E., Dekker, A. M., Gawor, K., Westeneng, H. -J., Tazelaar, G. H. P., van Eijk, K. R., Kooyman, M., Byrne, R. P., Doherty, M., Heverin, M., Al Khleifat, A., Iacoangeli, A., Shatunov, A., Ticozzi, N., Cooper-Knock, J., Smith, B. N., Gromicho, M., Chandran, S., Pal, S., Morrison, K. E., Shaw, P. J., Hardy, J., Orrell, R. W., Sendtner, M., Meyer, T., Basak, N., van der Kooi, A. J., Ratti, A., Fogh, I., Gellera, C., Lauria, G., Corti, S., Cereda, C., Sproviero, D., D'Alfonso, S., Soraru, G., Siciliano, G., Filosto, M., Padovani, A., Chio, A., Calvo, A., Moglia, C., Brunetti, M., Canosa, A., Grassano, M., Beghi, E., Pupillo, E., Logroscino, G., Nefussy, B., Osmanovic, A., Nordin, A., Lerner, Y., Zabari, M., Gotkine, M., Baloh, R. H., Bell, S., Vourc'H, P., Corcia, P., Couratier, P., Millecamps, S., Meininger, V., Salachas, F., Mora Pardina, J. S., Assialioui, A., Rojas-Garcia, R., Dion, P. A., Ross, J. P., Ludolph, A. C., Weishaupt, J. H., Brenner, D., Freischmidt, A., Bensimon, G., Brice, A., Durr, A., Payan, C. A. M., Saker-Delye, S., Wood, N. W., Topp, S., Rademakers, R., Tittmann, L., Lieb, W., Franke, A., Ripke, S., Braun, A., Kraft, J., Whiteman, D. C., Olsen, C. M., Uitterlinden, A. G., Hofman, A., Rietschel, M., Cichon, S., Nothen, M. M., Amouyel, P., Comi, G., Riva, N., Lunetta, C., Gerardi, F., Cotelli, M. S., Rinaldi, F., Chiveri, L., Guaita, M. C., Perrone, P., Ceroni, M., Diamanti, L., Ferrarese, C., Tremolizzo, L., Delodovici, M. L., Bono, G., Manera, U., Vasta, R., Bombaci, A., Casale, F., Fuda, G., Salamone, P., Iazzolino, B., Peotta, L., Cugnasco, P., De Marco, G., Torrieri, M. C., Palumbo, F., Gallone, S., Barberis, M., Sbaiz, L., Gentile, S., Mauro, A., Mazzini, L., De Marchi, F., Corrado, L., Bertolotto, A., Gionco, M., Leotta, D., Odddenino, E., Imperiale, D., Cavallo, R., Pignatta, P., De Mattei, M., Geda, C., Papurello, D. M., Gusmaroli, G., Comi, C., Labate, C., Ruiz, L., Ferrandi, D., Rota, E., Aguggia, M., Di Vito, N., Meineri, P., Ghiglione, P., Launaro, N., Dotta, M., Di Sapio, A., Giardini, G., Tiloca, C., Peverelli, S., Taroni, F., Pensato, V., Castellotti, B., Comi, G. P., Del Bo, R., Gagliardi, S., Raggi, F., Simoncini, C., Lo Gerfo, A., Inghilleri, M., Ferlini, A., Simone, I. L., Passarella, B., Guerra, V., Zoccolella, S., Nozzoli, C., Mundi, C., Leone, M., Zarrelli, M., Tamma, F., Valluzzi, F., Calabrese, G., Boero, G., Rini, A., Traynor, B. J., Singleton, A. B., Mitne Neto, M., Cauchi, R. J., Ophoff, R. A., Wiedau-Pazos, M., Lomen-Hoerth, C., van Deerlin, V. M., Grosskreutz, J., Roediger, A., Gaur, N., Jork, A., Barthel, T., Theele, E., Ilse, B., Stubendorff, B., Witte, O. W., Steinbach, R., Hubner, C. A., Graff, C., Brylev, L., Fominykh, V., Demeshonok, V., Ataulina, A., Rogelj, B., Koritnik, B., Zidar, J., Ravnik-Glavac, M., Glavac, D., Stevic, Z., Drory, V., Povedano, M., Blair, I. P., Kiernan, M. C., Benyamin, B., Henderson, R. D., Furlong, S., Mathers, S., Mccombe, P. A., Needham, M., Ngo, S. T., Nicholson, G. A., Pamphlett, R., Rowe, D. B., Steyn, F. J., Williams, K. L., Mather, K. A., Sachdev, P. S., Henders, A. K., Wallace, L., de Carvalho, M., Pinto, S., Petri, S., Weber, M., Rouleau, G. A., Silani, V., Curtis, C. J., Breen, G., Glass, J. D., Brown, R. H., Landers, J. E., Shaw, C. E., Andersen, P. M., Groen, E. J. N., van Es, M. A., Pasterkamp, R. J., Fan, D., Garton, F. C., Mcrae, A. F., Davey Smith, G., Gaunt, T. R., Eberle, M. A., Mill, J., Mclaughlin, R. L., Hardiman, O., Kenna, K. P., Wray, N. R., Tsai, E., Runz, H., Franke, L., Al-Chalabi, A., Van Damme, P., van den Berg, L. H., and Veldink, J. H.

Published
2022

26. The Challenge of the Astronomical Diaries from Babylon: Authors, Concern, Scholarship, and Worldview Reconsidered.

Author

VAN DER SPEK, R. J.

Subjects
*ASTRONOMY, *NONFICTION, BABYLON (Extinct city)
Abstract

The Astronomical Diaries are a unique corpus of documents from Babylon containing daily observations of celestial and terrestrial phenomena in the last half millennium before the common era. They provide direct information on how Babylonian scholars conducted scientific research and viewed political, economic, and religious events of their time--in other words, how they experienced their era. The book under review is a good introduction to this corpus. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

BAKKER, M. K., VAN DER SPEK, R. A. A., VAN RHEENEN, W., Morel, S., Bourcier, R., HOSTETTLER, I. C., ALG, V. S., VAN EIJK, K. R., KOIDO, M., Akiyama, M., TERAO, C., Matsuda, K., WALTERS, R. G., Lin, K., Li, L., MILLWOOD, I. Y., Chen, Z., Rouleau, G. A., Zhou, S., RANNIKMAE, K., SUDLOW, C. L. M., Houlden, H., VAN DEN BERG, L. H., Dina, C., Naggara, O., GENTRIC, J. C., Shotar, E., Eugene, F., DESAL, H., WINSVOLD, B. S., BORTE, S., JOHNSEN, M. B., BRUMPTON, B. M., SANDVEI, M. S., WILLER, C. J., Hveem, K., ZWART, J. A., VERSCHUREN, W. M. M., Friedrich, C. M., Hirsch, S., Schilling, S., DAUVILLIER, J., Martin, O., Jones, G. T., BOWN, M. J., KO, N. U., Kim, H., COLEMAN, J. R. I., Breen, G., ZAROFF, J. G., KLIJN, C. J. M., Malik, R., DICHGANS, M., Sargurupremraj, Muralidharan, Tatlisumak, T., Amouyel, P., Debette, Stephanie, RINKEL, G. J. E., WORRALL, B. B., Pera, J., SLOWIK, A., GAAL-PAAVOLA, E. I., NIEMELA, M., JAASKELAINEN, J. E., VON UND ZU FRAUNBERG, M., LINDGREN, A., BRODERICK, J. P., WERRING, D. J., Woo, D., REDON, R., Bijlenga, P., Kamatani, Y., VELDINK, J. H., RUIGROK, Y. M., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, cardiovascular diseases
Abstract

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2020

31. CHCHD10 variants in amyotrophic lateral sclerosis: where Is the evidence?

Author

Consortium, P.M.A.L.S.S., Veldink, J.H., Shaw, P.J., Tazelaar, G.H.P., van Rheenen, W., Pulit, S.L., van der Spek, R., Dekker, A.M., Moisse, M., McLaughlin, R.L., Sproviero, W., Kenna, K.P., Kooyman, M., van Doormaal, P.T.C., van Eijk, K.E., Middelkoop, B.M., Schellevis , R.D., Brands, W.J., Al-Chalabi , A., Morrison, K.E., Newhouse, S.E., Shaw, C.E., van Es, M.A., Nazli Basak, A., Akçimen, F., Kocoglu, C., Tunca, C., Povedano, M., Mora, J.S., Glass , J.D., van Damme, P., Robberecht , W., Hardiman, O., Landers, J.E., and van den Berg, L.H.

Abstract

Objective: After the initial report of a CHCHD10 mutation in mitochondrial disease with features resembling amyotrophic lateral sclerosis (ALS), CHCHD10 mutations have been considered to be a frequent cause for ALS. However, the exact pathogenicity and clinical significance of these mutations remain unclear. Here, we aimed to determine the role of CHCHD10 mutations in ALS.\ud Methods: We analyzed 4,365 whole genome sequenced ALS patients and 1,832 controls from 7 different countries and examined all nonsynonymous single nucleotide variants in CHCHD10. These were tested for association with ALS, independently and in aggregate using several genetic burden tests (including sequence kernel association test [SKAT], optimal unified test \ud [SKAT-O], and Firth logistic regression).\ud Results: We identified 3 new variants in cases, but only 1 was ALS-specific. lso, 1 control-specific mutation was identified. There was no increased burden of rare coding mutations among ALS patients compared to controls \ud (p=0.86, p=0.86, and p=0.88 for SKAT, SKAT-O, and Firth, respectively). The few carriers with potential pathogenic CHCHD10 mutations exhibited a slowly progressive ALS-like phenotype with atypical features such as myopathy and\ud deafness. \ud Interpretation: CHCHD10 mutations seem to be a far less prevalent cause of pure ALS than previously suggested, and instead appear related to more complex phenotypes. There appears to be insufficient evidence for the pathogenicity of most previously reported variants in pure ALS. This study shows that routine testing for CHCHD10 mutations in pure ALS is not recommended and illustrates the importance of sufficient genetic and functional evidence in establishing pathogenicity of genetic variants.

Published
2018

32. Political memory in and after the persian empire

Author

Silverman, Jason M., Waerzeggers, Caroline, Rung, Edward, Anderson, Björn, Nielsen, Nielsen, De Breucker, Geert, Kaper, Olaf E., Smoláriková, Květa, Colburn, Henry P., Wasmuth, Melanie, Bledsoe, Seth A., Eckhardt, Benedikt, Makhlaiuk, Aleksandr V., Wilson, Ian Douglas, Mitchell, Christine, Fried, Lisbeth S., Foroutan, Kiyan, van der Spek, R. J., Silverman, Jason M. (ed.), and Waerzeggers, Caroline (ed.)

Subjects
HISTORIA SOCIAL, DINASTIA AQUEMENIDA, HISTORIA POLITICA, HISTORIOGRAFIA, HISTORIA ANTIGUA, ORIENTE ANTIGUO, CERCANO ORIENTE, DINASTIAS, IRAN, HISTORIA CULTURAL, IMPERIO PERSA
Abstract

Fil: Rung, Edward. Kazan Federal University; Rusia Fil: Anderson, Björn. University of Iowa; Estados Unidos Fil: Nielsen, John P. N. Bradley University; Estados Unidos Fil: De Breucker, Geert. University of Groningen; Países Bajos Fil: Kaper, Olaf E. Leiden University; Países Bajos Fil: Waerzeggers, Caroline. Leiden University; Países Bajos Fil: Smoláriková, Květa. Czech Institute of Egyptology; República Checa Fil: Smoláriková, Květa. Charles University Prague; República Checa Fil: Colburn, Henry P. Getty Research Institute; Estados Unidos Fil: Wasmuth, Melanie. Investigadora Independiente; Suiza Fil: Bledsoe, Seth A. Florida State University; Estados Unidos Fil: Eckhardt, Benedikt. Universität Bremen; Alemania Fil: Makhlaiuk, Aleksandr V. Lobachevsky State University of Nizhni Novgorod; Rusia Fil: Wilson, Ian Douglas. University of Alberta; Canadá Fil: Mitchell, Christine. Saint Andrew’s College; Canadá Fil: Fried, Lisbeth S. University of Michigan; Estados Unidos Fil: Foroutan, Kiyan. Leiden University; Países Bajos Fil: Silverman, Jason M. Leiden University; Países Bajos Fil: van der Spek, R. J. Vrije Universiteit Amsterdam; Países Bajos Introducción: This volume comprises revised presentations from the 2014 symposium plus an additional contribution by Melanie Wasmuth, this introduction, and an overall critical assessment by R. J. van der Spek, who was also present at the symposium. We regret that not all of the participants of the symposium were able to contribute to this publication, especially with the resulting loss of discussion of certain areas of the empire (sadly even the heartland itself), but we trust the ones collected here profitably explore the issues from a variety of perspectives. The collection begins with a discussion of the Kingdom-cum-Satrapy of Lydia. Eduard Rung considers the notable lack of Lydian independence efforts through two topics; two early appointments by Cyrus the Great (Tabalus and Pactyes) and the early (and only attested) Lydian revolt by Pactyes. In his analysis, native elites were totally replaced from the Lydian administration following the revolt leading to the memory of Croesus’s kingdom losing any local political effectiveness...

Published
2015

36. Seleuceia (2) in Pieria

Author

Jones, Arnold Hugh Martin, primary, Seyrig, Henri, additional, Sherwin-White, Susan Mary, additional, and van der Spek, R. J., additional

Published
2016
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47. The Latest on Seleucid Empire Building in the East.

Author

VAN DER SPEK, R. J.

Subjects
*SELEUCIDS, *HISTORIANS, *THEORY of knowledge, *HISTORIOGRAPHY, *ARCHIVES
Abstract

Sonja Plischke's Die Seleukiden und Iran is an attempt to study Seleucid empire building in Iran. In view of the fact that indigenous written sources from Iran are practically absent, Plischke decided to include Babylonia in this work, since the written cuneiform evidence from that region is fairly abundant. She detects some general tendencies--such as religious policy and the general wish to connect the different parts of the empire--supported by a personal conception of Seleucid kingship, beside more specific treatment of different regions. In my view, the Seleucids probably did not pay sufficient attention to the East, so that their control weakened. I take the opportunity to discuss the Babylonian sources, correct errors in Plischke's use of them, and adduce some new publications. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Seleucids

Author

Sherwin-White, Susan Mary, primary and van der Spek, R. J., additional

Published
2015
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