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156 results on '"van der Schoot, E."'

4. High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation

Author

Marshall, G M, Dalla Pozza, L, Sutton, R, Ng, A, de Groot-Kruseman, H A, van der Velden, V H, Venn, N C, van den Berg, H, de Bont, E S J M, Maarten Egeler, R, Hoogerbrugge, P M, Kaspers, G J L, Bierings, M B, van der Schoot, E, van Dongen, J, Law, T, Cross, S, Mueller, H, de Haas, V, Haber, M, Révész, T, Alvaro, F, Suppiah, R, Norris, M D, and Pieters, R

Published
2013
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14. MASS-SCALE EXTENSIVE GENOTYPING OF 3000 RBC SAMPLES BY BLOODCHIP∩ V 1.0: P-450

Author

Martínez, M. López, Chinnapapagari, S. K.R., Olsson, M. L., Nogués, N., Scott, M. L., Pisacka, M., Daniels, G., van der Schoot, E., Muniz-Diaz, E., Madgett, T. E., Storry, J. R., Beiboer, S. H., Maaskant -van Wijk, P. A., von Zabern, I., Jiménez, E., Tejedor, J., Azkarate, M., Vesga, M. A., Camacho, E., Cheroutre, G., Link, A., Jinoch, P., Svobodova, I., Martinez, A., de Haas, M., Flegel, W. A., and Avent, N. D.

Published
2009

15. MASS-SCALE COMPREHENSIVE RHD GENOTYPING OF 3000 SAMPLES USING BLOODCHIP∩ V 1.0: P-449

Author

Martínez, M. López, Chinnapapagari, S. K.R., Olsson, M. L., Scott, M. L., Nogués, N., Pisacka, M., Daniels, G., van der Schoot, E., Muniz-Diaz, E., Madgett, T. E., Storry, J. R., Beiboer, S. H., Maaskant -van Wijk, P. A., von Zabern, I., Jiménez, E., Tejedor, D., Azkarate, M., Vesga, M. A., Camacho, E., Cheroutre, G., Link, A., Jinoch, P., Svobodova, I., Martinez, A., de Haas, M., Flegel, W. A., and Avent, N. D.

Published
2009

17. Neurocognitive functioning of children with mild to borderline intellectual disabilities and psychiatric disorders: profile characteristics and predictors of behavioural problems.

Author

Santegoeds, E., van der Schoot, E., Roording‐Ragetlie, S., Klip, H., and Rommelse, N.

Subjects
*EXECUTIVE function, *THOUGHT & thinking, *COGNITION, *TASK performance, *REGRESSION analysis, *FUNCTIONAL assessment, *BEHAVIOR disorders in children, *CHILD Behavior Checklist, *T-test (Statistics), *CHILD psychopathology, *PEOPLE with intellectual disabilities, *REACTION time
Abstract

Background: The aim of the current study was twofold: first, to uncover a neurocognitive profile of normative and relative strengths and weaknesses that characterises an extremely vulnerable group of children with mild to borderline intellectual disabilities (MBID) and co‐morbid psychiatric disorders, and second, to investigate the relevance of these neurocognitive functions explaining internalising and externalising symptoms. Method: We recruited 45 children (Mage = 9.5, SDage = 1.7; range 6–13 years) with MBID (Full‐Scale IQ 50–85) and at least one psychiatric disorder. Neurocognitive functioning was examined utilising the Wechsler Intelligence Scale for Children – Fifth Edition (WISC‐V) indices and the Cognitive Task Application (COTAPP), a comprehensive computerised self‐paced task designed in such a manner that 'g' (an overall tendency of children with MBID to execute tasks with a slower reaction time and a higher error rate) has been corrected for in the administration of the task (i.e. completely self‐paced) and in the operationalisation of outcome measures. Behavioural problems were measured using the CBCL and TRF. One‐sample t‐tests and binomial tests were carried out to compare performance with normative data. Regression analyses were used to examine the relationship between neurocognitive parameters and mental health. Results: Compared with normative data, very small to very large effect sizes were found, indicating clear heterogeneity amongst neurocognitive domains relevant for children with MBID. Two prominent neurocognitive weaknesses emerged: processing speed – characterised by slowness and unstableness combined with a high drift rate and delayed processing of the previous trial, particularly under higher cognitive demands – and working memory – in terms of a weaker central executive and 'slave' systems to temporarily store information. Both domains were not clearly predictive of internalising or externalising problems. Conclusion: Children with MBID and psychiatric disorders are hampered by a strongly diminished processing speed and working memory capacity, together resulting in an overall limited processing capacity that may underlie the general developmental delays on domains that depend on fast and parallel processing of information (i.e. language, reading, mathematics and more complex forms of social cognition). Neurocognitive vulnerabilities are neither necessary nor sufficient to explain internalising and externalising problems; rather, a mismatch between the support needs and adaptations these children need, arising from their diminished processing capacity, and the inadequacy of the environment to compensate for this vulnerability may be of relevance. [ABSTRACT FROM AUTHOR]

Published
2022
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19. CD antigens 2001

Author

Mason, D.Y, André, P, Bensussan, A, Buckley, C, Civin, C, Clark, E, de Haas, M, Goyert, S, Hadam, M, Hart, D, Hořejší, V, Meuer, S, Morissey, J, Schwartz-Albiez, R, Shaw, S, Simmons, D, Uguccioni, M, van der Schoot, E, Viver, E, and Zola, H

Published
2001

20. Detection of Minimal Residual Disease (MRD) in High Risk Neuroblastoma Correlates with Outcome: Final Results of International GPOH-DCOG Prospective Validation Study

Author

Van Zogchel, L., De Carolis, B., van Wezel, E., Stutterheim, J., Zappeij-Kannegieter, L., van Doornum, M., Schumacher-Kuckelkorn, R., Gecht, J., Simon, T., Caron, H., Fiocco, M., van der Schoot, E., Hero, B., Berthold, F., Tytgat, G., Van Zogchel, L., De Carolis, B., van Wezel, E., Stutterheim, J., Zappeij-Kannegieter, L., van Doornum, M., Schumacher-Kuckelkorn, R., Gecht, J., Simon, T., Caron, H., Fiocco, M., van der Schoot, E., Hero, B., Berthold, F., and Tytgat, G.

Published
2018

21. Large scale association analysis of novel genetic loci for coronary artery disease

Author

Amouyel, P., Arveiler, D., Boekholdt, S. M., Braund, P., Bruse, P., Bumpstead, S. J., Bugert, P., Cambien, F., Danesh, J., Deloukas, P., Doering, A., Ducimetiere, P., Dunn, R. M., El Mokhtari, N. E., Erdmann, J., Evans, A., Ewels, P., Ferrieres, J., Fischer, Matthias, Frossard, P., Garner, S., Gieger, C., Gohri, M. J. R., Goodall, A. H., Grosshennig, A., Hall, A., Hardwick, R., Haukijarvi, A., Hengstenberg, C., Illig, T., Karvanen, J., Kastelein, J., Kee, F., Khaw, K. T., Kluter, H., Konig, I. R., Kuulasmaa, K., Laiho, P., Luc, G., Marz, W., McGinnis, R., McLaren, W., Meisinger, C., Morrison, C., Ou, X., Ouwehand, W. H., Preuss, M., Proust, C., Ravindrarajah, R., Renner, W., Rice, K., Ruidavets, J. B., Saleheen, D., Salomaa, V., Samani, N. J., Sandhu, M. S., Schafer, A. S., Scholz, M., Schreiber, Stefan, Schunkert, H., Silander, K., Singh, R., Soranzo, N., Stark, K., Stegmayr, B., Stephens, J., Thompson, J., Tiret, L., Trip, M. D., van der Schoot, E., Virtamo, J., Wareham, N. J., Wichmann, H. E., Wiklund, P. G., Wright, B., Ziegler, A., Zwaginga, J. J., Amsterdam Cardiovascular Sciences, and Cardiology

Subjects
Male, Risk, Single-nucleotide polymorphism, Locus (genetics), Genome-wide association study, Coronary Artery Disease, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, White People, Article, Coronary artery disease, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, Family history, Aged, 030304 developmental biology, Genetic association, Genetics, 0303 health sciences, business.industry, Case-control study, Odds ratio, Middle Aged, medicine.disease, Case-Control Studies, Female, business, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study
Abstract

Background— Combined analysis of 2 genome-wide association studies in cases enriched for family history recently identified 7 loci (on 1p13.3, 1q41, 2q36.3, 6q25.1, 9p21, 10q11.21, and 15q22.33) that may affect risk of coronary artery disease (CAD). Apart from the 9p21 locus, the other loci await substantive replication. Furthermore, the effect of these loci on CAD risk in a broader range of individuals remains to be determined. Methods and Results— We undertook association analysis of single nucleotide polymorphisms at each locus with CAD risk in 11 550 cases and 11 205 controls from 9 European studies. The 9p21.3 locus showed unequivocal association (rs1333049, combined odds ratio [OR]=1.20, 95% CI [1.16 to 1.25], probability value=2.81×10 −21 ). We also confirmed association signals at 1p13.3 (rs599839, OR=1.13 [1.08 to 1.19], P =1.44×10 −7 ), 1q41 (rs3008621, OR=1.10 [1.04 to 1.17], P =1.02×10 −3 ), and 10q11.21 (rs501120, OR=1.11 [1.05 to 1.18], P =4.34×10 −4 ). The associations with 6q25.1 (rs6922269, P =0.020) and 2q36.3 (rs2943634, P =0.032) were borderline and not statistically significant after correction for multiple testing. The 15q22.33 locus did not replicate. The 10q11.21 locus showed a possible sex interaction ( P =0.015), with a significant effect in women (OR=1.29 [1.15 to 1.45], P =1.86×10 −5 ) but not men (OR=1.03 [0.96 to 1.11], P =0.387). There were no other strong interactions of any of the loci with other traditional risk factors. The loci at 9p21, 1p13.3, 2q36.3, and 10q11.21 acted independently and cumulatively increased CAD risk by 15% (12% to 18%), per additional risk allele. Conclusions The findings provide strong evidence for association between at least 4 genetic loci and CAD risk. Cumulatively, these novel loci have a significant impact on risk of CAD at least in European populations.

Published
2009
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23. Abstract O.16: Comprehensive Genotyping Of The FCGR2/3 Locus Reveals A Novel Association Of FCGR2C-ORF With Susceptibility To Kawasaki Disease

Author

Kuijpers, Taco W, primary, Tacke, Carline E, additional, Nagelkerke, Sietse Q, additional, Breunis, Willemijn B, additional, Hoang, Long T, additional, Png, Eileen, additional, Geissler, Judy, additional, Tanck, Michael W, additional, Ellis, Justine A, additional, Ponsonby, Anne L, additional, Davila, Sonia, additional, Khor, Chiea C, additional, de Boer, Martin, additional, van der Heijden, Joris, additional, Fijnvandraat, Karin, additional, van der Schoot, E., additional, van den Berg, Timo K, additional, Yeung, Rae S, additional, Levin, Michael L, additional, Burgner, David, additional, Shimizu, Chisato, additional, Burns, Jane C, additional, and Hibberd, Martin L, additional

Published
2015
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27. The role of job alienation in work ability deterioration and unhealthy ageing

Author

Camerino, D., Conway, P.M., van der Heijden, Beatrice, van der Schoot, E., Pokorski, J., Estryn-Behar, M., Hasselhorn, H.M., Costa, G., Goedhart, W.J.A., Ilmarinen, J., and Faculty of Behavioural, Management and Social Sciences

Subjects
IR-76637, METIS-225534
Abstract

The main purpose of this study is to illustrate how, within the nursing profession, work ability can be deteriorated by a job alienation mechanism which acts differently according to age. From the total number of nurses participating in the NEXT Study, a sample of 27,146 nurses was selected. In addition to age, “Job demands”, “Job control” and “Harassment at work” were considered as determinants of job alienation. “Overcommitment”, “Uncertainty about patients' treatment” and “Work meaning” were used as symptoms of job alienation. Finally, “Work Ability Index” (WAI) was employed as the outcome variable. A structural equation model was used to test the job alienation hypothesis. The model demonstrated a good fit with the data. Overcommitment, uncertainty about patients' treatment and work meaning had a direct effect on WAI. High job demands, high harassment at work, low job control and age had both direct and indirect effects (via overcommitment, uncertainty about patients' treatment and work meaning) on WAI. Low work ability in older nurses is due to ageing and to an increase in overcommitment yielded by perceived high demands, low job control and high harassment at work. On the contrary, among the nurses under 50 years old, decrease of WAI turned out to be more associated with higher uncertainty about patients' treatment and lower work meaning, which both affect the possibility to reach more professional competence and develop occupational expertise.

Published
2005

37. High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation

Author

Marshall, GM, Dalla Pozza, L, Sutton, R, Ng, A, De Groot-Kruseman, HA, Van Der Velden, VH, Venn, NC, Van Den Berg, H, De Bont, ESJM, Maarten Egeler, R, Hoogerbrugge, PM, Kaspers, GJL, Bierings, MB, Van Der Schoot, E, Van Dongen, J, Law, T, Cross, S, Mueller, H, De Haas, V, Haber, M, Révész, T, Alvaro, F, Suppiah, R, Norris, MD, Pieters, R, Marshall, GM, Dalla Pozza, L, Sutton, R, Ng, A, De Groot-Kruseman, HA, Van Der Velden, VH, Venn, NC, Van Den Berg, H, De Bont, ESJM, Maarten Egeler, R, Hoogerbrugge, PM, Kaspers, GJL, Bierings, MB, Van Der Schoot, E, Van Dongen, J, Law, T, Cross, S, Mueller, H, De Haas, V, Haber, M, Révész, T, Alvaro, F, Suppiah, R, Norris, MD, and Pieters, R

Abstract

Children with acute lymphoblastic leukemia (ALL) and high minimal residual disease (MRD) levels after initial chemotherapy have a poor clinical outcome. In this prospective, single arm, Phase 2 trial, 111 Dutch and Australian children aged 1-18 years with newly diagnosed, t(9;22)-negative ALL, were identified among 1041 consecutively enrolled patients as high risk (HR) based on clinical features or high MRD. The HR cohort received the AIEOP-BFM (Associazione Italiana di Ematologia ed Oncologia Pediatrica (Italy)-Berlin-Frankfurt- Münster ALL Study Group) 2000 ALL Protocol I, then three novel HR chemotherapy blocks, followed by allogeneic transplant or chemotherapy. Of the 111 HR patients, 91 began HR treatment blocks, while 79 completed the protocol. There were 3 remission failures, 12 relapses, 7 toxic deaths in remission and 10 patients who changed protocol due to toxicity or clinician/parent preference. For the 111 HR patients, 5-year event-free survival (EFS) was 66.8% (±5.5) and overall survival (OS) was 75.6% (±4.3). The 30 patients treated as HR solely on the basis of high MRD levels had a 5-year EFS of 63% (±9.4%). All patients experienced grade 3 or 4 toxicities during HR block therapy. Although cure rates were improved compared with previous studies, high treatment toxicity suggested that novel agents are needed to achieve further improvement. © 2013 Macmillan Publishers Limited.

Published
2013

41. International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology: Cancun report (2012)

Author

Storry, J. R., primary, Castilho, L., additional, Daniels, G., additional, Flegel, W. A., additional, Garratty, G., additional, de Haas, M., additional, Hyland, C., additional, Lomas-Francis, C., additional, Moulds, J. M., additional, Nogues, N., additional, Olsson, M. L., additional, Poole, J., additional, Reid, M. E., additional, Rouger, P., additional, van der Schoot, E., additional, Scott, M., additional, Tani, Y., additional, Yu, L.-C., additional, Wendel, S., additional, Westhoff, C., additional, Yahalom, V., additional, and Zelinski, T., additional

Published
2013
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42. Organizational configuration of hospitals succeeding in attracting and retaining nurses

Author

Stordeur, S., D'Hoore, William, Hasselhorn, H. M., Müller, B. H., Tackenberg, P., Kümmerling, A., Simon, M., Büscher, A., D'Hoore, W., Braeckman, L., Kiss, P., Verpraet, R., Laine, M., Wickström, G., Estryn-Behar, M., Le Nezet, O., Gould, D., Camerino, D., Conway, P., Van Der Heijden, B., Van Der Schoot, E., Oginska, H., Pokorski, J., Radkiewicz, P., Widerszal-Bazyl, M., Hanzlikova, A., Kovarova, M., Josephson, M., Lindberg, P., Stordeur, S., D'Hoore, William, Hasselhorn, H. M., Müller, B. H., Tackenberg, P., Kümmerling, A., Simon, M., Büscher, A., D'Hoore, W., Braeckman, L., Kiss, P., Verpraet, R., Laine, M., Wickström, G., Estryn-Behar, M., Le Nezet, O., Gould, D., Camerino, D., Conway, P., Van Der Heijden, B., Van Der Schoot, E., Oginska, H., Pokorski, J., Radkiewicz, P., Widerszal-Bazyl, M., Hanzlikova, A., Kovarova, M., Josephson, M., and Lindberg, P.

Abstract

Aim. This paper contrasts structural and managerial characteristics of low- and high-turnover hospitals, and describes the organizational configuration of attractive hospitals. Background. In countries facing nurse shortages and turnover, some hospitals succeed in recruiting and retaining nurses. In Magnet Hospitals, managerial practices and environmental characteristics increase nurses' job satisfaction and their commitment to the organization, which in turn decreases nurse turnover. Such an approach suggests that organizations are best understood as clusters of interconnected structures and practices, i.e. organizational configurations rather than entities whose components can be understood in isolation. Method. From a sample of 12 hospitals whose nurse turnover was studied for 1 year, structural and organizational features of hospitals in the first and fourth quartiles, i.e. attractive (turnover <3.1%) vs. conventional (turnover >11.8%) were contrasted. A questionnaire, including perceptions of health-related factors, job demands, stressors, work schedules, organizational climate, and work adjustments antecedent to turnover, was received from 401 nurses working in attractive hospitals (response rate = 53.8%) and 774 nurses in conventional hospitals (response rate = 54.5%). Findings. Structural characteristics did not differentiate attractive and conventional hospitals, but employee perceptions towards the organization differed strikingly. Differences were observed for risk exposure, emotional demands, role ambiguity and conflicts, work-family conflicts, effort-reward imbalance and the meaning of work, all in favour of attractive hospitals (P < 0.001). Relationships with nursing management, work ability and satisfaction with working time, handover shifts and schedules were also better in attractive hospitals (P < 0.001). Job satisfaction and commitment were higher in attractive hospitals, whereas burnout and intention to leave were lower (P < 0.0

Published
2007

43. P50 Novel Activatory and Inhibitory Platelet Receptors Identified Through Comparative Gene Expression Profiling of Megakaryocytes and Erythroblasts

Author

Macaulay, I. C., primary, Tijssen, M. R., additional, Thijssen-Timmer, D., additional, Gusnanto, A., additional, Carr, P., additional, Steward, M., additional, Langford, C., additional, Ellis, P., additional, Dudbridge, F., additional, Zwaginga, J., additional, Watkins, N. A., additional, van der Schoot, E., additional, and Ouwehand, W. H., additional

Published
2006
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49. CD antigens 2001.

Author

Mason, D, André, P, Bensussan, A, Buckley, C, Civin, C, Clark, E, de Haas, M, Goyert, S, Hadam, M, Hart, D, Horejsí, V, Meuer, S, Morrissey, J, Schwartz-Albiez, R, Shaw, S, Simmons, D, Uguccioni, M, van der Schoot, E, Vivier, E, and Zola, H

Published
2001
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