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25 results on '"van der Pol, Susanne M.A."'

5. Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Author

Derada Troletti, Claudio, primary, Enzmann, Gaby, additional, Chiurchiù, Valerio, additional, Kamermans, Alwin, additional, Tietz, Silvia Martina, additional, Norris, Paul C., additional, Jahromi, Neda Haghayegh, additional, Leuti, Alessandro, additional, van der Pol, Susanne M.A., additional, Schouten, Marijn, additional, Serhan, Charles N., additional, de Vries, Helga E., additional, Engelhardt, Britta, additional, and Kooij, Gijs, additional

Published
2021
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7. Single‐cell profiling of circulating and brain‐resident immune cells in a mouse model for amyloidosis and in aged mice

Author

van Olst, Lynn, primary, Verhoeff, Jan, additional, Schetters, Sjoerd T.T., additional, Hulshof, Lianne A., additional, van Dijk, Roland, additional, van der Pol, Susanne M.A., additional, Schouten, Marijn, additional, Vallejo, Juan J. Garcia, additional, van Der Flier, Wiesje, additional, Teunissen, Charlotte E., additional, Middeldorp, Jinte, additional, and de Vries, Helga E., additional

Published
2020
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11. Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

Author

van Olst, Lynn, primary, Rodriguez-Mogeda, Carla, additional, Picon-Munoz, Carmen, additional, Kiljan, Svenja, additional, James, Rachel E., additional, Kamermans, Alwin, additional, van der Pol, Susanne M.A., additional, Knoop, Lydian, additional, Drost, Evelien, additional, Franssen, Marc, additional, Schenk, Geert, additional, Geurts, Jeroen J.G., additional, Amor, Sandra, additional, Mazarakis, Nicholas D., additional, van Horssen, Jack, additional, de Vries, Helga E., additional, Reynolds, Richard, additional, and Witte, Maarten E., additional

Published
2020
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12. Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma

Author

Bikhezar, Fatima (author), de Kruijff, R.M. (author), van der Meer, A.J.G.M. (author), Torrelo Villa, G. (author), van der Pol, Susanne M.A. (author), Becerril Aragon, Gabriel (author), Gasol Garcia, Ana (author), Denkova, A.G. (author), Narayan, Ravi S. (author), Bikhezar, Fatima (author), de Kruijff, R.M. (author), van der Meer, A.J.G.M. (author), Torrelo Villa, G. (author), van der Pol, Susanne M.A. (author), Becerril Aragon, Gabriel (author), Gasol Garcia, Ana (author), Denkova, A.G. (author), and Narayan, Ravi S. (author)

Abstract

Background and purpose: Glioblastoma multiforme (GBM) is the most aggressive subtype of malignant gliomas, with an average survival rate of 15 months after diagnosis. More than 90% of all GBMs have activating mutations in the MAPK/ERK pathway. Recently, we showed the allosteric MEK1/2 inhibitor binimetinib (MEK162) to inhibit cell proliferation and to enhance the effect of radiation in preclinical human GBM models. Because the free drug cannot pass the blood–brain barrier (BBB), we investigated the use of nanocarriers for transport of the drug through the BBB and its efficacy when combined with radiotherapy and temozolomide (TMZ) in glioma spheroids. Methods: In vitro studies were performed using multicellular U87 human GBM spheroids. Polymeric nanocarriers (polymersomes) were loaded with MEK162. The interaction between nanocarrier delivered MEK162, irradiation and TMZ was studied on the kinetics of spheroid growth and on protein expression in the MAPK/ERK pathway. BBB passaging was evaluated in a transwell system with human cerebral microvascular endothelial (hCMEC/D3) cells. Results: MEK162 loaded polymersomes inhibited spheroid growth. A synergistic effect was found in combination with fractionated irradiation and an additive effect with TMZ on spheroid volume reduction. Fluorescent labeled polymersomes were taken up by human cerebral microvascular endothelial cells and passed the BBB in vitro. Conclusion: MEK162 loaded polymersomes are taken up by multicellular spheroids. The nanocarrier delivered drug reduced spheroid growth and inhibited its molecular target. MEK162 delivered via polymersomes showed interaction with irradiation and TMZ. The polymersomes crossed the in vitro BBB model and therewith offer exciting challenges ahead for delivery of therapeutics agents to brain tumours., RST/Applied Radiation & Isotopes, RST/Technici Pool, ChemE/Advanced Soft Matter

Published
2019
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14. Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Author

Kooij, Gijs, primary, Troletti, Claudio Derada, additional, Leuti, Alessandro, additional, Norris, Paul C., additional, Riley, Ian, additional, Albanese, Maria, additional, Ruggieri, Serena, additional, Libreros, Stephania, additional, van der Pol, Susanne M.A., additional, van het Hof, Bert, additional, Schell, Yoëlle, additional, Guerrera, Gisella, additional, Buttari, Fabio, additional, Mercuri, Nicola Biagio, additional, Centonze, Diego, additional, Gasperini, Claudio, additional, Battistini, Luca, additional, de Vries, Helga E., additional, Serhan, Charles N., additional, and Chiurchiù, Valerio, additional

Published
2019
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15. Mycobacteria employ two different mechanisms to cross the blood-brain barrier

Author

van Leeuwen, Lisanne M., primary, Boot, Maikel, additional, Kuijl, Coen, additional, Picavet, Daisy I., additional, van Stempvoort, Gunny, additional, van der Pol, Susanne M.A., additional, de Vries, Helga E., additional, van der Wel, Nicole N., additional, van der Kuip, Martijn, additional, van Furth, A. Marceline, additional, van der Sar, Astrid M., additional, and Bitter, Wilbert, additional

Published
2018
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17. Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis

Author

Kooij, Gijs, primary, Mizee, Mark R., additional, van Horssen, Jack, additional, Reijerkerk, Arie, additional, Witte, Maarten E., additional, Drexhage, Joost A.R., additional, van der Pol, Susanne M.A., additional, van het Hof, Bert, additional, Scheffer, George, additional, Scheper, Rik, additional, Dijkstra, Christine D., additional, van der Valk, Paul, additional, and de Vries, Helga E., additional

Published
2010
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18. Magnetic Resonance Imaging of Monocytes Labeled with Ultrasmall Superparamagnetic Particles of Iron Oxide Using Magnetoelectroporation in an Animal Model of Multiple Sclerosis

Author

Engberink, Raoul D. Oude, primary, van der Pol, Susanne M.A., additional, Walczak, Pjotr, additional, van der Toorn, Annette, additional, Viergever, Max A., additional, Dijkstra, Christine D., additional, Bulte, Jeff W.M., additional, de Vries, Helga E., additional, and Blezer, Erwin L.A., additional

Published
2010
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20. T lymphocytes impair P-glycoprotein function during neuroinflammation

Author

Kooij, Gijs, primary, van Horssen, Jack, additional, de Lange, Elizabeth C.M., additional, Reijerkerk, Arie, additional, van der Pol, Susanne M.A., additional, van het Hof, Bert, additional, Drexhage, Joost, additional, Vennegoor, Anke, additional, Killestein, Joep, additional, Scheffer, George, additional, Oerlemans, Ruud, additional, Scheper, Rik, additional, van der Valk, Paul, additional, Dijkstra, Christine D., additional, and de Vries, Helga E., additional

Published
2010
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21. Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement

Author

Vellinga, Machteld M., primary, Oude Engberink, Raoul D., additional, Seewann, Alexandra, additional, Pouwels, Petra J.W., additional, Wattjes, Mike P., additional, van der Pol, Susanne M.A., additional, Pering, Christiane, additional, Polman, Chris H., additional, de Vries, Helga E., additional, Geurts, Jeroen J.G., additional, and Barkhof, Frederik, additional

Published
2008
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25. Pro-resolving lipid mediator lipoxin A4attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Author

Derada Troletti, Claudio, Enzmann, Gaby, Chiurchiù, Valerio, Kamermans, Alwin, Tietz, Silvia Martina, Norris, Paul C., Jahromi, Neda Haghayegh, Leuti, Alessandro, van der Pol, Susanne M.A., Schouten, Marijn, Serhan, Charles N., de Vries, Helga E., Engelhardt, Britta, and Kooij, Gijs

Abstract

The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role of SPMs in MS remains largely unknown. Here, we provide in vivoevidence that treatment with the SPM lipoxin A4(LXA4) ameliorates clinical symptoms of experimental autoimmune encephalomyelitis (EAE) and inhibits CD4+and CD8+T cell infiltration into the central nervous system (CNS). Moreover, we show that LXA4potently reduces encephalitogenic Th1 and Th17 effector functions, both in vivoand in isolated human T cells from healthy donors and patients with relapsing-remitting MS. Finally, we demonstrate that LXA4affects the spinal cord lipidome by significantly reducing the levels of pro-inflammatory lipid mediators during EAE. Collectively, our findings provide mechanistic insight into LXA4-mediated amelioration of neuro-inflammation and highlight the potential clinical application of LXA4for MS.

Published
2021
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