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17 results on '"van der Nat, J. M."'

2. Abstracts of short lectures

Author

Rauwald, H. W., Conner, J., Gray, A., Reynolds, T., Waterman, P., Hartmann, T., Adolph, R. -D., Ehmke, A., Sander, H., Toppel, G., Witte, L., Nyiredy, Sz., Sticher, O., Erdelmeier, C. A. J., van Leeuwen, P. A. S., Kinghorn, A. D., Dallenbach-Tölke, K., Wink, M., Hennessy, Deirdre, Hook, Ingrid, Sheridan, Helen, Mersinger, R., Dornauer, H., Reinhard, E., Heide, L., Tabata, M., Knobloch, K., Jansen, H., Müller, B., Adzet, T., Vila, R., Cañigueral, S., Budzianowski, J., Bachmann, P., Czygan, F. -C., de Witte, P., Lemli, J., 't Hart, L. A., van Enckevort, P. H., Labadie, R. P., van der Heijden, R., de Keyzer, H. H. M., Verhey, E. R., Schripsema, J., Harkes, P. A. A., Verpoorte, R., Svendsen, A. Baerheim, Croom, Jr., E. M., Letchamo, W., Vömel, A., Bauer, R., Wray, V., Wagner, H., Marston, A., Hostettmann, K., Andersson, L., Bohlin, L., Iorizzi, M., Riccio, R., Minale, L., Moreno-Lopez, J., van Beek, T. A., van Bokhoven, H., Kraus, J., Blaschek, W., Franz, G., van den Berg, A. J. J., Radema, M. H., Corthout, J., Pieters, L., Claeys, M., Vanden Berghe, D., Vlietinck, A. J., Dungen, F. M. v. d., Vermeulen, N. P. E., Fischer, F. C., Gijbels, M. J. H., Caspers, P. W. J., Gijbels, M. J. M., Fung, S. Y., Herrebout, W. M., van Gelder, W. M. J., van der Graaf, G. M., Pennings, E. J. M., Huizer, H., van Zuilen, K., Kosasi, S., van der Leer, T., ten Hoope, S. M., van der Nat, J. M., van der Sluis, W. G., Bosch, R. v. d., Duine, J. A., Heijden, R. v. d., Leer, T. v. d., Pieters, L. A., Totté, J., Saleh, M. M., Abbas, R. Z., Zwaving, J. H., Sarer, E., Looman, A., Scheffer, J. J. C., Meijer, A. H., Langezaal, C. R., Simons, J. M., Hoof, L. Van, Vanden Berghe, D. A., Woerdenbag, H. J., Hendriks, H., van der Berg, K., van Stralen, R., Malingré, Th. M., Konings, A. W. T., Lemstra, W., Abdo, S., De Bernardi, M., Marinoni, G., Samaniego, S., Mellerio, G., Vidari, G., Adjibadé, Y., Kuballa, B., Cabalion, P., Anton, R., Ibáñez, C., Monasterio, I., Ayoub, S. M. Hussein, Yankov, L. K., Ovtcharov, R. O., Bartsch, C., BaŞaran, A. A., Calis, I., Nishibe, S., Berger, S., Junior, P., Kopanski, L., Beuscher, N., Billeter, M., Meier, B., Döll, M., Braunewell, H., Skrzypczak, L., Wesolowska, M., Gross, G. A., Winkler, T., Colombo, M. L., Tome, F., Crespi-Perellino, N., Guicciardi, A., Minghetti, A., Speroni, E., Vincieri, F., Vita-Finzi, P., Gabetta, B., Scilingo, A., Dorsaz, A. C., Hostettmann, M., Ebert, M., Economou, D., Nahrstedt, A., Schiebel, H. -M., McDowell, M., Eich, E., Kohaupt, G., Stopp, K., Maidhof, A., Müller, W. E. G., Schade, P., Müllen, K., Eilert, U., Wolters, B., El Tanbouly, N., Beck, J. P., Hanna, S., El Alfy, T., Ersöz, T., Chulia, A. J., Garcia, J., Frahm, A. W., Beutner, D., Gautier, P., Shongo, D., Vekemans, X., Van Koninckxloo, M., Van Haelen, M., Lefébvre, C., Gehrmann, B., Kraus, Lj., Giger, E., Baumann, T. W., Heinzer, F., Meusy, J. -P., Chavanne, M., Glombitza, K. -W., Knöss, W., Deutscher, B., Piepenbrink, G., Peter, J., Greinwald, R., Schultze, W., Gundidza, Mazuru, Hölzl, J., Hess, S., Holm, Y., Aho, E., Holopainen, M., Järvelä, K., Seppänen, T., von Schantz, M., Huhtikangas, A., Lapinjoki, S., Veräjänkorva, H., Heiskanen, J., Kauppinen, V., Lounasmaa, M., Huovinen, K., Härmälä, P., Ottoila, P., Jerga, Chr, Merfort, I., Willuhn, G., Jiménez, A., Manez, S., Villar, A., Kahlos, K., Kiviranta, J., Karppanen, H., Huovinen, H., Koch, A., Kreis, H., May, U., Kuštrak, P., Pepeljnjak, S., Antolić, A., Blažević, N., Laakso, I., Ekundayo, O., Oguntimein, B., Lorentzen, Bente, Rørdam, Anne Marie, Madaus, A., Marcinek, Chr, Martinelli, E. M., Seraglia, R., Briquez, M., Reginault, P., Máthé, Jr., I., Máthé, I., Máthé, A., Meiss, P., Meng, Qingchang, Zhu, Naijue, Chen, Weixin, Miething, H., Seger, V., Hänsel, R., Neuhöfer, H., Lurz, G., Noller, P., Oksman-Caldentey, K. -M., Vuorela, H., Isenegger, M., Strauss, A., Pachaly, P., Adnan, A. Z., Lansing, A., Sin, K. S., Pauli, A., Payá, M., Ivorra, M. D., Poginsky, B., Westendorf, J., Marquardt, H., Potterat, O., Stoeckli-Evans, H., Msonthi, J. D., Randriaminahy, M., Proksch, P., Reher, G., Samochowiec, L., Wójcicki, J., Kadlubowska, D., Kownacka, A., Şarer, E., Sayron-Atasü, E., Cihangir, V., Schmaus, G., Kubeczka, K. -H., Schütz, M., Schulz, G., Stahl-Biskup, E., Seidel, S., Sepasgosarian, J., Laitalainen, T., Światek, L., Grabias, B., Tanker, M., Kurucu, S., Tanker, N., Thron, U., Reichling, J., Martin, R., Vargas, D., Dominguez, X. A., Vollmann, C., Pernilä, H., Nystrand, N., Hinkkanen, R., Walker, J. R. L., Cole, A. L. J., Warncke, D., Kadlubowska, P., Ziegler, S. J., and Zogg, G.

Published
1987
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11. Ethnopharmacognostical survey of Azadirachta indica A. Juss (Meliaceae).

Author

van der Nat JM, van der Sluis WG, de Silva KT, and Labadie RP

Subjects
Animals, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents therapeutic use, Botany, Flavonoids chemistry, Flavonoids isolation & purification, Flavonoids pharmacology, Humans, Insecticides isolation & purification, Insecticides pharmacology, Structure-Activity Relationship, Terpenes chemistry, Terpenes isolation & purification, Terpenes pharmacology, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts pharmacology, Trees
Abstract

Literature data on respectively botany, chemistry, ethnopharmacology, pharmacology and toxicology of Azadirachta indica A. Juss. (Meliaceae) are reviewed and evaluated. In traditional literature, preparations of the tree are claimed to be vulnerable in wide spectrum of diseases. Especially for inflammation-related diseases a good correlation is found with the results of recent experimental investigations. In addition, a variety of other biological activities are reported. Most frequently the effects can be attributed to compounds representing the structural classes of the limonoids, phenolics and macromolecules. Reported toxicity of preparations and isolated compounds are low, except for the seed oil. In conclusion, A. indica can be regarded as a valuable plant source for the rationalisation of its use in traditional medicine and for modern drug development.

Published
1991
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12. In vitro immunosuppressive activities of recently developed anthracycline cytostatics.

Author

van der Nat JM, Beijnen JH, Driebergen RJ, Thart LA, van Dijk H, Underberg WJ, and Labadie RP

Subjects
Complement Activation drug effects, Leukocyte Migration-Inhibitory Factors biosynthesis, Lipid Metabolism, Luminescent Measurements, Lymphocytes metabolism, Naphthacenes pharmacology, Oxidation-Reduction, Structure-Activity Relationship, Antibiotics, Antineoplastic pharmacology, Immunosuppressive Agents pharmacology, Lymphocytes drug effects, Neutrophils drug effects
Abstract

The effects of a series of seven anthracycline cytostatics on various human leukocyte functions, namely the production of Migration Inhibition Factor (MIF) by lymphocytes and the production of chemiluminescence by activated polymorphonuclear leukocytes (PMNs), as well as on classical and alternative pathways of activation of human complement were investigated. In addition, lipophilic and electrochemical properties of the compounds were determined, by measuring their High Performance Liquid Chromatography (HPLC) capacity ratio (k') and half-wave reduction potential (E1/2). The antitumor agents under investigation suppressed, in most cases, lymphocyte and PMN functions, whereas complement activity remained unaffected. The extent of suppressive effects showed a good correlation with the lipophilicity of the compounds, while no correlation with reduction potentials was found.

Published
1988

13. Immunomodulatory activity of an aqueous extract of Azadirachta indica stem bark.

Author

van der Nat JM, Klerx JP, van Dijk H, de Silva KT, and Labadie RP

Subjects
Complement Pathway, Classical drug effects, Humans, In Vitro Techniques, Kinetics, Leukocyte Migration-Inhibitory Factors biosynthesis, Luminescent Measurements, Neutrophils immunology, Phagocytosis drug effects, Pokeweed Mitogens pharmacology, Sri Lanka, Adjuvants, Immunologic, Plant Extracts pharmacology
Abstract

The interference of an aqueous extract of the stem bark of Azadirachta indica with different parts of the human immune system was investigated. The extract showed strong anticomplementary effects which were dose-and time-dependent and most pronounced in the classical complement pathway assay. Moreover, a dose-dependent decrease in the chemiluminescence of polymorphonuclear leukocytes was observed and a dose-dependent increase in the production of migration inhibition factor by lymphocytes.

Published
1987
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14. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro.

Author

van der Nat JM, Beijnen JH, van Dijk H, Underberg WJ, and Labadie RP

Subjects
Animals, Cell Line, Mice, Mice, Inbred Strains, Monocytes drug effects, Macrophage Migration-Inhibitory Factors antagonists & inhibitors, Mitomycins pharmacology
Abstract

The effects of a series of mitomycins in a modified version of the Migration Inhibition Factor (MIF) test were investigated. This modified assay, which uses monocytes of the mouse cell line WEHI3 as target cells for MIF, discriminates between effects on the migrating monocytes, the production of MIF by lymphocytes and the activity of the produced MIF. The 7-methoxy mitomycins were found to be more active than the 7-amino and 7-hydroxy derivatives in suppressing both the spontaneous migration of target monocytes and the MIF production by lymphocytes. Neither of the compounds had a significant effect on the activity of produced MIF. A relationship between the activities of the mitomycins and their lipophilicity and polarographic half-wave potential is discussed. Further attention is paid to the stability of the mitomycins under the test conditions and additional advantages of the modified MIF assay over related in vitro tests for cell-mediated immunity.

Published
1986
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15. Thin-layer chromatographic bioassay of iridoid and secoiridoid glucosides with a fungitoxic aglucone moiety using beta-glucosidase and the fungus Penicillium expansum as a test organism.

Author

van der Sluis WG, van der Nat JM, and Labadie RP

Subjects
Chromatography, Thin Layer methods, Iridoids, Structure-Activity Relationship, beta-Glucosidase, Antifungal Agents, Glucosides isolation & purification, Glycosides isolation & purification, Microbial Sensitivity Tests methods, Penicillium drug effects, Pyrans isolation & purification
Published
1983
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16. Characterization of anti-complement compounds from Azadirachta indica.

Author

van der Nat JM, Hart LA, van der Sluis WG, van Dijk H, van den Berg AJ, de Silva KT, and Labadie RP

Subjects
Chemical Phenomena, Chemistry, Chromatography, Gas, Chromatography, Gel, Chromatography, Ion Exchange, Chromatography, Thin Layer, Dialysis, India, Monosaccharides analysis, Plant Extracts analysis, Plant Extracts pharmacology, Plant Proteins pharmacology, Sri Lanka, Complement Inactivator Proteins, Plants, Medicinal chemistry
Abstract

The crude aqueous extract of Azadirachta indica bark possesses an inhibitory activity on both classical (CP) and alternative pathway (AP) activation of human complement. Purification of the compounds with the guidance of the AP-inhibitory activity involved extraction with methanol, dialysis, ion-exchange procedures and gel-permeation chromatography. This sequence yielded two polymers, NB-I and NB-II, one a highly active compound with a relatively low molecular weight (NB-II) and the other a less active compound with a high molecular weight (NB-I). The polymers were characterized by using colour reactions, TLC, GLC and HPLC after hydrolysis and gel-permeation chromatography as peptidoglycans. The carbohydrate part consisted predominantly of glucose. Arabinose, galactose and mannose were present in minor amounts (NB-II) or only as traces (NB-I). Protein was present for 5.5% in NB-I and for 9.8% in NB-II.

Published
1989
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17. Decomposition of mitomycin and anthracycline cytostatics in cell culture media.

Author

Beijnen JH, Van der Nat JM, Labadie RP, and Underberg WJ

Subjects
Antibiotics, Antineoplastic, Cells, Cultured, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Daunorubicin analogs & derivatives, Daunorubicin metabolism, Doxorubicin analogs & derivatives, Doxorubicin metabolism, Epirubicin, Humans, Idarubicin, Kinetics, Mitomycin, Naphthacenes metabolism, Porfiromycin metabolism, Culture Media, Mitomycins metabolism
Abstract

The chemical stability of members of two groups of cytostatics, mitomycins and anthracyclines, has been studied in four different cell culture media enriched with serum. Stability was determined with the use of high performance liquid chromatography. In the group of mitomycins, the 7-aminomitosanes appeared to be relatively stable during a seven days incubation period at 37 degrees C when compared to the 7-methoxy congeners. The anthracycline derivatives, 4-demethoxy-daunorubicin, doxorubicin and its 4'-analogues showed half-lives of about 10-20 hours. Doxorubicinol and daunorubicin were found to be more stable. Anthracycline degradation products could be traced with the use of thin layer chromatography. All main degradation products originate from hydrolytic reactions. No enzymatic conversions could be observed. These observations may be of importance for the correct interpretation of the effects of mitomycins or anthracyclines on cells incubated in a cell culture medium.

Published
1986

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