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45 results on '"van der Meulen, Marijke"'

2. A quality control system for ligand-binding assay of plasma renin activity: Proof-of-concept within a pharmacodynamic study

Author

Läer, Stephanie, Breitkreutz, Jörg, Klingmann, Ingrid, Lagler, Florian, de Hoon, Jan, Dalinghaus, Michiel, Bajcetic, Milica, de Wildt, Saskia, Clarke, Anne Keatley, Breur, Johannes, Male, Christoph, Ablonczy, Laslo, Mir, Thomas, Vukomanovic, Vladislav, Dukic, Milan, Jovanovic, Ida, Burckhardt, Bjoern B., Cawello, Willi, Kleine, Karl, Moder, Angelika, Obarcanin, Emina, Wagner, Peter, Walsh, Jennifer, van Hecken, Anne, Spatenkova, Lucie, Ali, Mohsin, Božić, Bojana, Burdman, Maja Bijelić Ilja, Ciplea, Agnes, Faisal, Muhammad, Farahani, Samieh, Feickert, Martin, Gangnus, Tanja, Lazic, Milica, Makowski, Nina, Suessenbach, Fabian, van der Meulen, Marijke, Popović, Saša, Parezanović, Miro, Smeets, Nori, Swoboda, Vanessa, Bojanin, Dragana, Đorđević, Stefan, Dragić, Jasminka, Holle, Ann-Kathrin, Jovičić, Bosiljka, Košutić, Jovan, Kozomara, Gordana, Majid, Haidara, Mitrović, Jadranka, Ninić, Sanja, Parezanovic, Miro, Parezanovic, Vojislav, Pavlović, Andrija, Prijić, Sergej, Rebić, Branislava, Stefanović, Igor, Tordas, Daniel, Vulićević, Irena, Bartels, Anke, Čeko, Andjelka, Herborts, Marissa, Hennink, Annelies, Kosanović, Bosiljka, Kostic, Sanja, Isailović, Ljiljana, Maksimovic, Jasmina, Manai, Badies, Martinović, Nada, Máté, Gyöngyi, Perišić, Miloš, Reljić, Jelena, Salamomovic, Regina Pirker Marta, Schlesner, Claudia, Tins, Jutta, Wissmann, Eva, Suessenbach, Fabian Konstantin, and Burckhardt, Bjoern Bengt

Published
2020
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4. Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Author

Bajcetic, Milica, de Wildt, Saskia N., Dalinghaus, Michiel, Breitkreutz, Jörg, Klingmann, Ingrid, Lagler, Florian B., Keatley-Clarke, Anne, Breur, Johannes MPJ., Male, Christoph, Jovanovic, Ida, Szatmári, Andras, Ablonczy, László, Burckhardt, Bjoern B., Cawello, Willi, Kleine, Karl, Obarcanin, Emina, Spatenkova, Lucie, Swoboda, Vanessa, van der Meulen, Marijke, Wagner, Peter, Walsh, Jennifer, and Läer, Stephanie

Published
2019
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5. The Dutch national paediatric heart transplantation programme:outcomes during a 23-year period

Author

Roest, Stefan, van der Meulen, Marijke H., van Osch-Gevers, Lennie M., Kraemer, Ulrike S., Constantinescu, Alina A., de Hoog, Matthijs, Bogers, Ad J.J.C., Manintveld, Olivier C., van de Woestijne, Pieter C., Dalinghaus, Michiel, Roest, Stefan, van der Meulen, Marijke H., van Osch-Gevers, Lennie M., Kraemer, Ulrike S., Constantinescu, Alina A., de Hoog, Matthijs, Bogers, Ad J.J.C., Manintveld, Olivier C., van de Woestijne, Pieter C., and Dalinghaus, Michiel

Abstract

Background: Since 1998, there has been a national programme for paediatric heart transplantations (HT) in the Netherlands. In this study, we investigated waiting list mortality, survival post-HT, the incidence of common complications, and the patients’ functional status during follow-up. Methods: All children listed for HT from 1998 until October 2020 were included. Follow-up lasted until 1 January 2021. Data were collected from the patient charts. Survival, post-operative complications as well as the functional status (Karnofsky/Lansky scale) at the end of follow-up were measured. Results: In total, 87 patients were listed for HT, of whom 19 (22%) died while on the waiting list. Four patients were removed from the waiting list and 64 (74%) underwent transplantation. Median recipient age at HT was 12.0 (IQR 7.2–14.4) years old; 55% were female. One-, 5‑, and 10-year survival post-HT was 97%, 95%, and 88%, respectively. Common transplant-related complications were rejections (50%), Epstein-Barr virus infections (31%), cytomegalovirus infections (25%), post-transplant lymphoproliferative disease (13%), and cardiac allograft vasculopathy (13%). The median functional score (Karnofsky/Lansky scale) was 100 (IQR 90–100). Conclusion: Children who undergo HT have an excellent survival rate up to 10 years post-HT. Even though complications post-HT are common, the functional status of most patients is excellent. Waiting list mortality is high, demonstrating that donor availability for this vulnerable patient group remains a major limitation for further improvement of outcome.

Published
2023

7. Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification

Author

van der Meulen, Marijke H., primary, Herkert, Johanna C., additional, den Boer, Susanna L., additional, du Marchie Sarvaas, Gideon J., additional, Blom, Nico, additional, ten Harkel, Arend D.J., additional, Breur, Hans M.P.J., additional, Rammeloo, Lukas A.J., additional, Tanke, Ronald, additional, Marcelis, Carlo, additional, van de Laar, Ingrid M.B.H., additional, Verhagen, Judith M.A., additional, Lekanne dit Deprez, Ronald H., additional, Barge-Schaapveld, Daniela Q.C.M., additional, Baas, Annette, additional, Sammani, Arjan, additional, Christiaans, Imke, additional, van Tintelen, J. Peter, additional, and Dalinghaus, Michiel, additional

Published
2022
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9. The Dutch national paediatric heart transplantation programme: outcomes during a 23-year period

Author

Roest, Stefan, primary, van der Meulen, Marijke H., additional, van Osch-Gevers, Lennie M., additional, Kraemer, Ulrike S., additional, Constantinescu, Alina A., additional, de Hoog, Matthijs, additional, Bogers, Ad J. J. C., additional, Manintveld, Olivier C., additional, van de Woestijne, Pieter C., additional, and Dalinghaus, Michiel, additional

Published
2022
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10. Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort:The Use of Genetic Testing in Risk Stratification

Author

van der Meulen, Marijke H., Herkert, Johanna C., den Boer, Susanna L., du Marchie Sarvaas, Gideon J., Blom, Nico A., Ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald B., Marcelis, Carlo, van de Laar, Ingrid M.B.H., Verhagen, Judith M.A., Lekanne Dit Deprez, Ronald H., Barge-Schaapveld, Daniela Q.C.M., Baas, Annette F., Sammani, Arjan, Christiaans, Imke, van Tintelen, J. Peter, Dalinghaus, Michiel, van der Meulen, Marijke H., Herkert, Johanna C., den Boer, Susanna L., du Marchie Sarvaas, Gideon J., Blom, Nico A., Ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald B., Marcelis, Carlo, van de Laar, Ingrid M.B.H., Verhagen, Judith M.A., Lekanne Dit Deprez, Ronald H., Barge-Schaapveld, Daniela Q.C.M., Baas, Annette F., Sammani, Arjan, Christiaans, Imke, van Tintelen, J. Peter, and Dalinghaus, Michiel

Abstract

BACKGROUND: This study aimed to describe the current practice and results of genetic evaluation in Dutch children with dilated cardiomyopathy and to evaluate genotype-phenotype correlations that may guide prognosis.METHODS: We performed a multicenter observational study in children diagnosed with dilated cardiomyopathy, from 2010 to 2017.RESULTS: One hundred forty-four children were included. Initial diagnostic categories were idiopathic dilated cardiomyopathy in 67 children (47%), myocarditis in 23 (16%), neuromuscular in 7 (5%), familial in 18 (13%), inborn error of metabolism in 4 (3%), malformation syndrome in 2 (1%), and "other" in 23 (16%). Median follow-up time was 2.1 years [IQR 1.0-4.3]. Hundred-seven patients (74%) underwent genetic testing. We found a likely pathogenic or pathogenic variant in 38 children (36%), most often in MYH7 (n = 8). In 1 patient initially diagnosed with myocarditis, a pathogenic LMNA variant was found. During the study, 39 patients (27%) reached study endpoint (SE: all-cause death or heart transplantation). Patients with a likely pathogenic or pathogenic variant were more likely to reach SE compared with those without (hazard ratio 2.8; 95% CI 1.3-5.8, P = 0.007), while transplant-free survival was significantly lower (P = 0.006). Clinical characteristics at diagnosis did not differ between the 2 groups.CONCLUSIONS: Genetic testing is a valuable tool for predicting prognosis in children with dilated cardiomyopathy, with carriers of a likely pathogenic or pathogenic variant having a worse prognosis overall. Genetic testing should be incorporated in clinical work-up of all children with dilated cardiomyopathy regardless of presumed disease pathogenesis.

Published
2022

11. Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification

Author

Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Genetica Klinische Genetica, Onderzoek Precision medicine, Genetica, van der Meulen, Marijke H, Herkert, Johanna C, den Boer, Susanna L, du Marchie Sarvaas, Gideon J, Blom, Nico, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Marcelis, Carlo, van de Laar, Ingrid M B H, Verhagen, Judith M A, Lekanne Dit Deprez, Ronald H, Barge-Schaapveld, Daniela Q C M, Baas, Annette, Sammani, Arjan, Christiaans, Imke, van Tintelen, J Peter, Dalinghaus, Michiel, Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Genetica Klinische Genetica, Onderzoek Precision medicine, Genetica, van der Meulen, Marijke H, Herkert, Johanna C, den Boer, Susanna L, du Marchie Sarvaas, Gideon J, Blom, Nico, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Marcelis, Carlo, van de Laar, Ingrid M B H, Verhagen, Judith M A, Lekanne Dit Deprez, Ronald H, Barge-Schaapveld, Daniela Q C M, Baas, Annette, Sammani, Arjan, Christiaans, Imke, van Tintelen, J Peter, and Dalinghaus, Michiel

Published
2022

12. Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome

Author

van der Meulen, Marijke, de Boer, S, Sarvaas, GJD, Blom, N, ten Harkel, ADJ (Arend), Breur, H, Rammeloo, LAJ, Tanke, R, Bogers, Ad, Helbing, W.A., Boersma, Eric, Dalinghaus, M., van der Meulen, Marijke, de Boer, S, Sarvaas, GJD, Blom, N, ten Harkel, ADJ (Arend), Breur, H, Rammeloo, LAJ, Tanke, R, Bogers, Ad, Helbing, W.A., Boersma, Eric, and Dalinghaus, M.

Abstract

Aims: We aimed to determine whether in children with dilated cardiomyopathy repeated measurement of known risk factors for death or heart transplantation (HTx) during disease progression can identify children at the highest risk for adverse outcome. Methods and results: Of 137 children we included in a prospective cohort, 36 (26%) reached the study endpoint (SE: all-cause death or HTx), 15 (11%) died at a median of 0.09 years [inter-quartile range (IQR) 0.03–0.7] after diagnosis, and 21 (15%) underwent HTx at a median of 2.9 years [IQR 0.8–6.1] after diagnosis. Median follow-up was 2.1 years [IQR 0.8–4.3]. Twenty-three children recovered at a median of 0.6 years [IQR 0.5–1.4] after diagnosis, and 78 children had ongoing disease at the end of the study. Children who reached the SE could be distinguished from those who did not, based on the temporal evolution of four risk factors: stunting of length growth (−0.42 vs. −0.02 length Z-score per year, P < 0.001), less decrease in N-terminal pro-B-type natriuretic peptide (NT-proBNP) (−0.26 vs. −1.06 2log pg/mL/year, P < 0.01), no decrease in left ventricular internal diastolic dimension (LVIDd; 0.24 vs. −0.60 Boston Z-score per year, P < 0.01), and increase in New York University Pediatric Heart Failure Index (NYU PHFI; 0.49 vs. −1.16 per year, P < 0.001). When we compared children who reached the SE with those with ongoing disease (leaving out the children who recovered), we found similar results, although the effects were smaller. In univariate analysis, NT-proBNP, length Z-score, LVIDd Z-score, global longitudinal strain (%), NYU PHFI, and age >6 years at presentation (all P < 0.001) were predictive of adverse outcome. In multivariate analysis, NT-proBNP appeared the only independent predictor for adverse outcome, a two-fold higher NT-proBNP was associated with a 2.8 times higher risk of the SE (hazard ratio 2.78, 95% confidence interval 1.81–3.94, P < 0.001). Conclusions: The evolution over tim

Published
2021

13. Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van der Meulen, Marijke, den Boer, Susanna, du Marchie Sarvaas, Gideon J., Blom, Nico, ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald, Bogers, Ad J.J.C., Helbing, Willem A., Boersma, Eric, Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van der Meulen, Marijke, den Boer, Susanna, du Marchie Sarvaas, Gideon J., Blom, Nico, ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald, Bogers, Ad J.J.C., Helbing, Willem A., Boersma, Eric, and Dalinghaus, Michiel

Published
2021

15. Pediatric Ventricular Assist Device Support in the Netherlands

Author

Rohde, Sofie, Antonides, Stan, Muslem, Rahat, van de Woestijne, Pieter, van der Meulen, Marijke, Krämer, Ulrike, Dalinghaus, M., Bogers, Ad, Rohde, Sofie, Antonides, Stan, Muslem, Rahat, van de Woestijne, Pieter, van der Meulen, Marijke, Krämer, Ulrike, Dalinghaus, M., and Bogers, Ad

Published
2020

16. Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials

Author

Burckhardt, BB, Ciplea, AM, Laven, A, Ablonczy, L, Klingmann, I, Läer, S, de Kleine, K, Dalinghaus, M., ?uki?, M, Breur, JMPJ, van der Meulen, Marijke, Swoboda, V, Schwender, H, Lagler, FB, Burckhardt, BB, Ciplea, AM, Laven, A, Ablonczy, L, Klingmann, I, Läer, S, de Kleine, K, Dalinghaus, M., ?uki?, M, Breur, JMPJ, van der Meulen, Marijke, Swoboda, V, Schwender, H, and Lagler, FB

Published
2020

17. Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, van der Meulen, Marijke H, Boer, Susanna den, du Marchie Sarvaas, Gideon J, Blom, Nico A, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Helbing, Willem A, Boersma, Eric, Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, van der Meulen, Marijke H, Boer, Susanna den, du Marchie Sarvaas, Gideon J, Blom, Nico A, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Helbing, Willem A, Boersma, Eric, and Dalinghaus, Michiel

Published
2020

18. Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Burckhardt, Bjoern B., Ciplea, Agnes Maria, Laven, Anna, Ablonczy, László, Klingmann, Ingrid, Läer, Stephanie, Kleine, Karl, Dalinghaus, Michiel, Đukić, Milan, Breur, Johannes M.P.J., van der Meulen, Marijke, Swoboda, Vanessa, Schwender, Holger, Lagler, Florian B., Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Burckhardt, Bjoern B., Ciplea, Agnes Maria, Laven, Anna, Ablonczy, László, Klingmann, Ingrid, Läer, Stephanie, Kleine, Karl, Dalinghaus, Michiel, Đukić, Milan, Breur, Johannes M.P.J., van der Meulen, Marijke, Swoboda, Vanessa, Schwender, Holger, and Lagler, Florian B.

Published
2020

19. Emotional and behavioral problems in children with dilated cardiomyopathy

Author

Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van der Mheen, Malindi, van der Meulen, Marijke H., den Boer, Susanna L., Schreutelkamp, Dayenne J., van der Ende, Jan, de Nijs, Pieter F.A., Breur, Johannes M.P.J., Tanke, Ronald B., Blom, Nico A., Rammeloo, Lukas A.J., ten Harkel, Arend D.J., du Marchie Sarvaas, Gideon J., Utens, Elisabeth M.W.J., Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van der Mheen, Malindi, van der Meulen, Marijke H., den Boer, Susanna L., Schreutelkamp, Dayenne J., van der Ende, Jan, de Nijs, Pieter F.A., Breur, Johannes M.P.J., Tanke, Ronald B., Blom, Nico A., Rammeloo, Lukas A.J., ten Harkel, Arend D.J., du Marchie Sarvaas, Gideon J., Utens, Elisabeth M.W.J., and Dalinghaus, Michiel

Published
2020

20. Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome

Author

van der Meulen, Marijke, primary, den Boer, Susanna, additional, du Marchie Sarvaas, Gideon J., additional, Blom, Nico, additional, ten Harkel, Arend D.J., additional, Breur, Hans M.P.J., additional, Rammeloo, Lukas A.J., additional, Tanke, Ronald, additional, Bogers, Ad J.J.C., additional, Helbing, Willem A., additional, Boersma, Eric, additional, and Dalinghaus, Michiel, additional

Published
2021
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21. Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials

Author

Burckhardt, Bjoern B., primary, Ciplea, Agnes Maria, additional, Laven, Anna, additional, Ablonczy, László, additional, Klingmann, Ingrid, additional, Läer, Stephanie, additional, Kleine, Karl, additional, Dalinghaus, Michiel, additional, Đukić, Milan, additional, Breur, Johannes M. P. J., additional, van der Meulen, Marijke, additional, Swoboda, Vanessa, additional, Schwender, Holger, additional, and Lagler, Florian B., additional

Published
2020
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22. A quality control system for ligand-binding assay of plasma renin activity: Proof-of-concept within a pharmacodynamic study

Author

Suessenbach, Fabian Konstantin, primary, Makowski, Nina, additional, Feickert, Martin, additional, Gangnus, Tanja, additional, Tins, Jutta, additional, Burckhardt, Bjoern Bengt, additional, Läer, Stephanie, additional, Breitkreutz, Jörg, additional, Klingmann, Ingrid, additional, Lagler, Florian, additional, de Hoon, Jan, additional, Dalinghaus, Michiel, additional, Bajcetic, Milica, additional, de Wildt, Saskia, additional, Clarke, Anne Keatley, additional, Breur, Johannes, additional, Male, Christoph, additional, Ablonczy, Laslo, additional, Mir, Thomas, additional, Vukomanovic, Vladislav, additional, Dukic, Milan, additional, Jovanovic, Ida, additional, Burckhardt, Bjoern B., additional, Cawello, Willi, additional, Kleine, Karl, additional, Moder, Angelika, additional, Obarcanin, Emina, additional, Wagner, Peter, additional, Walsh, Jennifer, additional, van Hecken, Anne, additional, Spatenkova, Lucie, additional, Ali, Mohsin, additional, Božić, Bojana, additional, Burdman, Maja Bijelić Ilja, additional, Ciplea, Agnes, additional, Faisal, Muhammad, additional, Farahani, Samieh, additional, Lazic, Milica, additional, Suessenbach, Fabian, additional, van der Meulen, Marijke, additional, Popović, Saša, additional, Parezanović, Miro, additional, Smeets, Nori, additional, Swoboda, Vanessa, additional, Bojanin, Dragana, additional, Đorđević, Stefan, additional, Dragić, Jasminka, additional, Holle, Ann-Kathrin, additional, Jovičić, Bosiljka, additional, Košutić, Jovan, additional, Kozomara, Gordana, additional, Majid, Haidara, additional, Mitrović, Jadranka, additional, Ninić, Sanja, additional, Parezanovic, Miro, additional, Parezanovic, Vojislav, additional, Pavlović, Andrija, additional, Prijić, Sergej, additional, Rebić, Branislava, additional, Stefanović, Igor, additional, Tordas, Daniel, additional, Vulićević, Irena, additional, Bartels, Anke, additional, Čeko, Andjelka, additional, Herborts, Marissa, additional, Hennink, Annelies, additional, Kosanović, Bosiljka, additional, Kostic, Sanja, additional, Isailović, Ljiljana, additional, Maksimovic, Jasmina, additional, Manai, Badies, additional, Martinović, Nada, additional, Máté, Gyöngyi, additional, Perišić, Miloš, additional, Reljić, Jelena, additional, Salamomovic, Regina Pirker Marta, additional, Schlesner, Claudia, additional, and Wissmann, Eva, additional

Published
2020
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23. A comprehensive quality control system suitable for academic research: application in a pediatric study

Author

Makowski, Nina, primary, Ciplea, Agnes M, additional, Ali, Mohsin, additional, Burdman, Ilja, additional, Bartel, Anke, additional, Burckhardt, Bjoern B, additional, Läer, Stephanie, additional, Breitkreutz, Jörg, additional, Klingmann, Ingrid, additional, Lagler, Florian, additional, de Hoon, Jan, additional, Dalinghaus, Michel, additional, Bajcetic, Milica, additional, de Wildt, Saskia, additional, Keatley Clarke, Anne, additional, Breur, Johannes, additional, Male, Christoph, additional, Ablonczy, Laslo, additional, Mir, Thomas, additional, Vukomanovic, Vladislav, additional, Dukic, Milan, additional, Jovanovic, Ida, additional, Burckhardt, Bjoern, additional, Cawello, Willi, additional, Kleine, Karl, additional, Moder, Angelika, additional, Obarcanin, Emina, additional, Wagner, Peter, additional, Walsh, Jennifer, additional, van Hecken, Anne, additional, Spatenkova, Lucie, additional, Mohsin, Ali, additional, Božić, Bojana, additional, Bijelić, Maja, additional, Ciplea, Agnes, additional, Faisal, Muhammed, additional, Farahani, Samieh, additional, Feickert, Martin, additional, Gangnus, Tanja, additional, Lazic, Milica, additional, Makowski, Nina, additional, Süssenbach, Fabian, additional, van der Meulen, Marijke, additional, Popović, Saša, additional, Parezanović, Miro, additional, Smeets, Nori, additional, Swoboda, Vanessa, additional, Bojanin, Dragana, additional, Đorđević, Stefan, additional, Dragić, Jasminka, additional, Holle, Ann-Kathrin, additional, Jovičić, Bosiljka, additional, Košutić, Jovan, additional, Kozomara, Gordana, additional, Majid, Haidara, additional, Mitrović, Jadranka, additional, Ninić, Sanja, additional, Parezanovic, Miro, additional, Parezanovic, Vojislav, additional, Pavlović, Andrija, additional, Prijić, Sergej, additional, Rebić, Branislava, additional, Stefanović, Igor, additional, Tordas, Daniel, additional, Vulićević, Irena, additional, čeko, Andjelka, additional, Herborts, Marissa, additional, Hennink, Annelies, additional, Kosanović, Bosiljka, additional, Kostic, Sanja, additional, Isailović, Ljiljana, additional, Maksimovic, Jasmina, additional, Manai, Badies, additional, Martinović, Nada, additional, Máté, Gyöngyi, additional, Perišić, Miloš, additional, Reljić, Jelena, additional, Pirker, Regina, additional, Salamomovic, Marta, additional, Schlesner, Claudia, additional, Tins, Jutta, additional, and Wissmann, Eva, additional

Published
2020
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24. Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: A European survey

Author

Díez, CC, Khalil, F, Schwender, H, Dalinghaus, M., Jovanovic, I, Makowski, N, Male, C, Bajcetic, M, van der Meulen, Marijke, de Wildt, Saskia, Ablonczy, L, Szatmári, A, Klingmann, I, Walsh, J, Läer, S, Díez, CC, Khalil, F, Schwender, H, Dalinghaus, M., Jovanovic, I, Makowski, N, Male, C, Bajcetic, M, van der Meulen, Marijke, de Wildt, Saskia, Ablonczy, L, Szatmári, A, Klingmann, I, Walsh, J, and Läer, S

Published
2019

25. Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Author

Bajcetic, M, de Wildt, Saskia, Dalinghaus, M., Breitkreutz, J, Klingmann, I, Lagler, FB, Keatley-Clarke, A, Breur, J, Male, C, Jovanovic, I, Szatmari, A, Ablonczy, L, Burckhardt, BB, Cawello, W, de Kleine, K, Obarcanin, E, Spatenkova, L, Swoboda, V, van der Meulen, Marijke, Wagner, P, Walsh, J, Laer, S, Bajcetic, M, de Wildt, Saskia, Dalinghaus, M., Breitkreutz, J, Klingmann, I, Lagler, FB, Keatley-Clarke, A, Breur, J, Male, C, Jovanovic, I, Szatmari, A, Ablonczy, L, Burckhardt, BB, Cawello, W, de Kleine, K, Obarcanin, E, Spatenkova, L, Swoboda, V, van der Meulen, Marijke, Wagner, P, Walsh, J, and Laer, S

Published
2019

26. How safe are ACE inhibitors for heart failure in children?

Author

van der Meulen, Marijke, Dalinghaus, M., Burch, M, Szatmari, A, Diez, CC, Khalil, F, Swoboda, V, Breur, J, Bajcetic, M, Jovanovic, I, Lagler, FB, Klingmann, I, Laeer, S, de Wildt, Saskia, Pediatrics, and Pediatric Surgery

Published
2018

27. Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

Author

van der Meulen, Marijke H., primary, Boer, Susanna den, additional, du Marchie Sarvaas, Gideon J., additional, Blom, Nico A., additional, ten Harkel, Arend D. J., additional, Breur, Hans M. P. J., additional, Rammeloo, Lukas A. J., additional, Tanke, Ronald, additional, Helbing, Willem A., additional, Boersma, Eric, additional, and Dalinghaus, Michiel, additional

Published
2019
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28. Emotional and behavioral problems in children with dilated cardiomyopathy

Author

van der Mheen, Malindi, primary, van der Meulen, Marijke H, additional, den Boer, Susanna L, additional, Schreutelkamp, Dayenne J, additional, van der Ende, Jan, additional, de Nijs, Pieter FA, additional, Breur, Johannes MPJ, additional, Tanke, Ronald B, additional, Blom, Nico A, additional, Rammeloo, Lukas AJ, additional, ten Harkel, Arend DJ, additional, du Marchie Sarvaas, Gideon J, additional, Utens, Elisabeth MWJ, additional, and Dalinghaus, Michiel, additional

Published
2019
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29. Pharmacotherapy in paediatric heart failure: a Delphi process

Author

Díez, Cristina C., primary, Khalil, Feras, additional, Makowski, Nina, additional, Schwender, Holger, additional, Jovanovic, Ida, additional, Dalinghaus, Michiel, additional, Walsh, Jennifer, additional, van der Meulen, Marijke, additional, Bajcetic, Milica, additional, de Wildt, Saskia N., additional, and Läer, Stephanie, additional

Published
2019
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30. Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: a European survey

Author

Castro Díez, Cristina, primary, Khalil, Feras, additional, Schwender, Holger, additional, Dalinghaus, Michiel, additional, Jovanovic, Ida, additional, Makowski, Nina, additional, Male, Christoph, additional, Bajcetic, Milica, additional, van der Meulen, Marijke, additional, de Wildt, Saskia N, additional, Ablonczy, László, additional, Szatmári, András, additional, Klingmann, Ingrid, additional, Walsh, Jennifer, additional, and Läer, Stephanie, additional

Published
2019
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31. How safe are ACE inhibitors for heart failure in children?

Author

Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Van Der Meulen, Marijke, Dalinghaus, Michiel, Burch, Michael, Szatmari, Andras, Diez, Cristina Castro, Khalil, Feras, Swoboda, Vanessa, Breur, Johannes, Bajcetic, Milica, Jovanovic, Ida, Lagler, Florian B., Klingmann, Ingrid, Laeer, Stephanie, Wildt, Saskian de, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Van Der Meulen, Marijke, Dalinghaus, Michiel, Burch, Michael, Szatmari, Andras, Diez, Cristina Castro, Khalil, Feras, Swoboda, Vanessa, Breur, Johannes, Bajcetic, Milica, Jovanovic, Ida, Lagler, Florian B., Klingmann, Ingrid, Laeer, Stephanie, and Wildt, Saskian de

Published
2018

32. Emotional and behavioral problems in children with dilated cardiomyopathy.

Author

van der Mheen, Malindi, van der Meulen, Marijke H, den Boer, Susanna L, Schreutelkamp, Dayenne J, van der Ende, Jan, de Nijs, Pieter FA, Breur, Johannes MPJ, Tanke, Ronald B, Blom, Nico A, Rammeloo, Lukas AJ, ten Harkel, Arend DJ, du Marchie Sarvaas, Gideon J, Utens, Elisabeth MWJ, and Dalinghaus, Michiel

Subjects
*AFFECTIVE disorders, *AGE distribution, *ANXIETY, *BEHAVIOR disorders in children, *CHILD Behavior Checklist, *COMPARATIVE studies, *MENTAL depression, *LONGITUDINAL method, *MEDICAL cooperation, *CLASSIFICATION of mental disorders, *SCIENTIFIC observation, *PSYCHOMETRICS, *QUESTIONNAIRES, *REFERENCE values, *RESEARCH, *RESEARCH funding, *SEX distribution, *ATTITUDES toward death, *SOCIAL support, *PARENT attitudes, *CROSS-sectional method, *PROPORTIONAL hazards models, *DATA analysis software, *DILATED cardiomyopathy, *DESCRIPTIVE statistics, *CHILDREN
Abstract

Background: Dilated cardiomyopathy (DCM) in children is an important cause of severe heart failure and carries a poor prognosis. Adults with heart failure are at increased risk of anxiety and depression and such symptoms predict adverse clinical outcomes such as mortality. In children with DCM, studies examining these associations are scarce. Aims: We studied whether in children with DCM: (1) the level of emotional and behavioral problems was increased as compared to normative data, and (2) depressive and anxiety problems were associated with the combined risk of death or cardiac transplantation. Methods: To assess emotional and behavioral problems in children with DCM, parents of 68 children, aged 1.5–18 years (6.9±5.7 years), completed the Child Behavior Checklist. Results: Compared to normative data, more young children (1.5–5 years) with DCM had somatic complaints (24.3% vs. 8.0%; p <.001), but fewer had externalizing problems (5.4% vs. 17.0%; p =.049). Overall internalizing problems did not reach significance. Compared to normative data, more older children (6–18 years) showed internalizing problems (38.7% vs. 17.0%; p =.001), including depressive (29.0% vs. 8.0%; p <.001) and anxiety problems (19.4% vs. 8.0%; p =.023), and somatic complaints (29.0% vs. 8.0%; p <.001). Anxiety and depressive problems, corrected for heart failure severity, did not predict the risk of death or cardiac transplantation. Conclusion: Children of 6 years and older showed more depressive and anxiety problems than the normative population. Moreover, in both age groups, somatic problems were common. No association with outcome could be demonstrated. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, Dalinghaus, Michiel, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, and Dalinghaus, Michiel

Published
2017

35. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, Dalinghaus, Michiel, Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, and Dalinghaus, Michiel

Published
2017

37. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

Boer, Suzanne, Flipse, Daan, van der Meulen, Marijke, Backx, A, Sarvaas, GJD, ten Harkel, ADJ (Arend), Iperen, GG, Rammeloo, LAJ, Tanke, RB, Helbing, W.A., Takken, T, Dalinghaus, M., Boer, Suzanne, Flipse, Daan, van der Meulen, Marijke, Backx, A, Sarvaas, GJD, ten Harkel, ADJ (Arend), Iperen, GG, Rammeloo, LAJ, Tanke, RB, Helbing, W.A., Takken, T, and Dalinghaus, M.

Published
2017

38. Question 1: How safe are ACE inhibitors for heart failure in children?

Author

van der Meulen, Marijke, primary, Dalinghaus, Michiel, additional, Burch, Michael, additional, Szatmari, Andras, additional, Castro Diez, Cristina, additional, Khalil, Feras, additional, Swoboda, Vanessa, additional, Breur, Johannes, additional, Bajcetic, Milica, additional, Jovanovic, Ida, additional, Lagler, Florian B, additional, Klingmann, Ingrid, additional, Laeer, Stephanie, additional, and de Wildt, Saskia N, additional

Published
2017
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39. Parent reports of health-related quality of life and heart failure severity score independently predict outcome in children with dilated cardiomyopathy

Author

den Boer, Susanna L., primary, Baart, Sara J., additional, van der Meulen, Marijke H., additional, van Iperen, Gabriëlle G., additional, Backx, Ad P., additional, ten Harkel, Arend D., additional, Rammeloo, Lukas A., additional, du Marchie Sarvaas, Gideon J., additional, Tanke, Ronald B., additional, Helbing, Willem A., additional, Utens, Elisabeth M., additional, and Dalinghaus, Michiel, additional

Published
2017
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40. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

den Boer, Susanna L., primary, Flipse, Daniël H. K., additional, van der Meulen, Marijke H., additional, Backx, Ad P. C. M., additional, du Marchie Sarvaas, Gideon J., additional, Ten Harkel, Arend D. J., additional, van Iperen, Gabriëlle G., additional, Rammeloo, Lukas A. J., additional, Tanke, Ronald B., additional, Helbing, Willem A., additional, Takken, Tim, additional, and Dalinghaus, Michiel, additional

Published
2016
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43. Risky missions: Dutch public opinion on peace-keeping in the Balkans

Author

Jan Van Der Meulen Marijke De Konink

Subjects
business.industry, Perception, media_common.quotation_subject, Political science, Political economy, Cold war, Public opinion, business, media_common, Peacekeeping
Abstract

In the waning years of the Cold War public opinion in the Netherlands showed unmistakable signs of a changing perception of the armed forces. For decades the latter were considered ‘necessary’ by some 80 per cent of the public. Measured year by year, gradually this figure declined, down to 66 per cent in 1989: still a considerable majority, but the downward trend was telling.

Published
2003
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44. Mechanical circulatory support in the Dutch National Paediatric Heart Transplantation Programme.

Author

van der Meulen, Marijke H., Dalinghaus, Michiel, Maat, Alexander P. W. M., van de Woestijne, Pieter C., van Osch, M., de Hoog, M., Kraemer, Ulrike S., and Bogers, Ad J. J. C.

Subjects
*HEART assist devices, *HEART transplantation, *HEART failure treatment, *EXTRACORPOREAL membrane oxygenation, *PERICARDIAL effusion, MORTALITY risk factors
Abstract

OBJECTIVES: Mechanical circulatory support (MCS) with a ventricular assist device (VAD) as a bridge to heart transplantation (HTx) or recovery may improve outcome in children with terminal heart failure. We report our experience with MCS in children eligible for HTx and its effect on waiting list mortality. METHODS: Retrospective single-centre cohort study, National Paediatric HTx Programme including all children eligible for HTx, since the introduction of MCS-VAD in 2006. RESULTS: A total of 43 patients were eligible for HTx, median age 11.7 years [Inter Quartile Range (IQR) 3.0–14.7]. In 18 patients, (42%) a VAD was implanted, 11 (61%) survived to HTx (n = 9) or recovery (n = 2). Techniques and devices used were left ventricular assist device (n = 16, 89%), in 4 cases preceded by extracorporeal membrane oxygenation (ECMO), and biventricular assist device (n = 2, 11%), both preceded by ECMO. In the VAD group, median time to death (n = 7) was 18 days (IQR 7–75), median time to HTx (n = 9) 66 days (IQR 33–223) and 2 patients recovered after 30 and 308 days. The main cause of death on MCS was neurological injury in 4 patients (22%) and systemic thrombo-embolic events in 2 (11%). The most common serious adverse events included confirmed thrombus requiring pump replacement (in 11 patients, 61%) and pericardial effusion leading to rethoracotomy (in 5 patients, 28%). Compared with the era before MCS (1998–2006), waiting list mortality decreased from 44 to 21%, and is now mainly related to complications of VAD support. CONCLUSIONS: Since the introduction of MCS-VAD, waiting list mortality halved and more children with end-stage heart failure survived to heart transplantation, thus improving outcome. Although there is substantial mortality and morbidity, overall mortality decreases, making MCS-VAD an essential therapeutic tool. The need for donor organs remains critically urgent. [ABSTRACT FROM AUTHOR]

Published
2015
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45. [Acute myocarditis due to Coxsackie virus B3 in two infants].

Author

van der Meulen M, van Doornum GJ, Corel LJ, Dalinghaus M, Fraaij PL, and de Hoog M

Subjects
Acute Disease, Coxsackievirus Infections mortality, Drinking, Enterovirus B, Human pathogenicity, Fatal Outcome, Humans, Infant, Newborn, Male, Myocarditis mortality, Myocarditis virology, Coxsackievirus Infections diagnosis, Enterovirus B, Human isolation & purification, Myocarditis diagnosis
Abstract

In the spring and summer of 2008 two seriously ill male infants were admitted to a paediatric intensive care unit. Initially, both had a fever, were drinking less and were pale complexioned. Physical examination revealed tachycardia, slow capillary filling and liver enlargement. Within a few hours, both infants developed circulatory and respiratory failure. A chest radiograph showed that the heart was enlarged and echocardiography revealed that the pump function of both ventricles was severely diminished. Myocarditis caused by Coxsackie virus B3 was diagnosed when the virus was demonstrated in serum and faeces. At the last follow-up, one infant still had severe pump function disorders, and the other one died. Coxsackie virus B3 is a non-polio enterovirus that usually causes mild clinical syndromes but is also associated with myocarditis and overwhelming, systemic neonatal infections. In neonates with mild symptoms one should be alert to progression to circulatory insufficiency, especially if the mother experiences a flu-like illness in the perinatal period. Early recognition of heart failure and adequate diagnostic testing for cardiotropic viruses is important as morbidity and mortality is considerable.

Published
2009

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