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1. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
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2. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Author

Sazonovs, Aleksejs, Stevens, Christine R., Venkataraman, Guhan R., Yuan, Kai, Avila, Brandon, Abreu, Maria T., Ahmad, Tariq, Allez, Matthieu, Ananthakrishnan, Ashwin N., Atzmon, Gil, Baras, Aris, Barrett, Jeffrey C., Barzilai, Nir, Beaugerie, Laurent, Beecham, Ashley, Bernstein, Charles N., Bitton, Alain, Bokemeyer, Bernd, Chan, Andrew, Chung, Daniel, Cleynen, Isabelle, Cosnes, Jacques, Cutler, David J., Daly, Allan, Damas, Oriana M., Datta, Lisa W., Dawany, Noor, Devoto, Marcella, Dodge, Sheila, Ellinghaus, Eva, Fachal, Laura, Farkkila, Martti, Faubion, William, Ferreira, Manuel, Franchimont, Denis, Gabriel, Stacey B., Ge, Tian, Georges, Michel, Gettler, Kyle, Giri, Mamta, Glaser, Benjamin, Goerg, Siegfried, Goyette, Philippe, Graham, Daniel, Hämäläinen, Eija, Haritunians, Talin, Heap, Graham A., Hiltunen, Mikko, Hoeppner, Marc, Horowitz, Julie E., Irving, Peter, Iyer, Vivek, Jalas, Chaim, Kelsen, Judith, Khalili, Hamed, Kirschner, Barbara S., Kontula, Kimmo, Koskela, Jukka T., Kugathasan, Subra, Kupcinskas, Juozas, Lamb, Christopher A., Laudes, Matthias, Lévesque, Chloé, Levine, Adam P., Lewis, James D., Liefferinckx, Claire, Loescher, Britt-Sabina, Louis, Edouard, Mansfield, John, May, Sandra, McCauley, Jacob L., Mengesha, Emebet, Mni, Myriam, Moayyedi, Paul, Moran, Christopher J., Newberry, Rodney D., O’Charoen, Sirimon, Okou, David T., Oldenburg, Bas, Ostrer, Harry, Palotie, Aarno, Paquette, Jean, Pekow, Joel, Peter, Inga, Pierik, Marieke J., Ponsioen, Cyriel Y., Pontikos, Nikolas, Prescott, Natalie, Pulver, Ann E., Rahmouni, Souad, Rice, Daniel L., Saavalainen, Päivi, Sands, Bruce, Sartor, R. Balfour, Schiff, Elena R., Schreiber, Stefan, Schumm, L. Philip, Segal, Anthony W., Seksik, Philippe, Shawky, Rasha, Sheikh, Shehzad Z., Silverberg, Mark S., Simmons, Alison, Skeiceviciene, Jurgita, Sokol, Harry, Solomonson, Matthew, Somineni, Hari, Sun, Dylan, Targan, Stephan, Turner, Dan, Uhlig, Holm H., van der Meulen, Andrea E., Vermeire, Séverine, Verstockt, Sare, Voskuil, Michiel D., Winter, Harland S., Young, Justine, Duerr, Richard H., Franke, Andre, Brant, Steven R., Cho, Judy, Weersma, Rinse K., Parkes, Miles, Xavier, Ramnik J., Rivas, Manuel A., Rioux, John D., McGovern, Dermot P. B., Huang, Hailiang, Anderson, Carl A., and Daly, Mark J.

Published
2022
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3. Retreatment with anti-tumor necrosis factor therapy in combination with an immunomodulator for recurrence of Crohn’s disease after ileocecal resection results in prolonged continuation as compared to anti-tumor necrosis factor monotherapy

Author

ten Bokkel Huinink, Sebastiaan., Beelen, Evelien M.J., ten Bokkel Huinink, Thomas, Hoentjen, Frank, G. L. Bodelier, Alexander, Dijkstra, Gerard, Romberg-Camps, Marielle, de Boer, Nanne K., Stassen, Laurents P.S., van der Meulen, Andrea E., West, Rachel, van Ruler, Oddeke, van der Woude, C. Janneke, and de Vries, Annemarie C.

Published
2023
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4. Current Status, Challenges, and Future Directions in Crohn's Disease.

Author

Selinger, Christian and van der Meulen, Andrea

Subjects
*CROHN'S disease, *INFLAMMATORY bowel diseases, *ULCERATIVE colitis, *DISEASE remission, *COVID-19 pandemic, *BLOOD testing
Abstract

This document is an editorial from the Journal of Clinical Medicine titled "Current Status, Challenges, and Future Directions in Crohn's Disease." It provides an update on the current state of Crohn's disease, including challenges and future directions. The editorial covers various topics related to Crohn's disease, such as early diagnosis, management of perianal Crohn's disease, classification systems, fibrosis, pregnancy management, frailty in older patients, the impact of the COVID-19 pandemic, radiological imaging, and advanced therapies. The authors present a summary of each topic and highlight key findings and recommendations from relevant studies. [Extracted from the article]

Published
2024
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5. Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Author

Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C., Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y., Jansen, Jeroen M., van der Meulen, Andrea E., Beukers, Ruud, Brink, Menno A., Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P., Naber, Ton H., Verhagen, Marc A., de Boer, Nanne K.H., and Mulder, Chris J.J.

Published
2019
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6. Impact of timing of primary ileocecal resection on prognosis in patients with Crohn’s disease

Author

Beelen, Evelien M J, primary, Arkenbosch, Jeanine H C, additional, Erler, Nicole S, additional, Sleutjes, Jasmijn A M, additional, Hoentjen, Frank, additional, Bodelier, Alexander G L, additional, Dijkstra, Gerard, additional, Romberg-Camps, Marielle, additional, de Boer, Nanne K, additional, Stassen, Laurents P S, additional, van der Meulen, Andrea E, additional, West, Rachel, additional, van Ruler, Oddeke, additional, van der Woude, C Janneke, additional, and de Vries, Annemarie C, additional

Published
2023
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7. Reply

Author

Straatmijer, Tessa, primary, Van Der Meulen, Andrea E., additional, and Duijvestein, Marjolijn, additional

Published
2023
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8. Impact of timing of primary ileocecal resection on prognosis in patients with Crohn's disease

Author

Beelen, Evelien M.J., Arkenbosch, Jeanine H.C., Erler, Nicole S., Sleutjes, Jasmijn A.M., Hoentjen, Frank, Bodelier, Alexander G.L., Dijkstra, Gerard, Romberg-Camps, Marielle, de Boer, Nanne K., Stassen, Laurents P.S., van der Meulen, Andrea E., West, Rachel, van Ruler, Oddeke, van der Woude, C. Janneke, de Vries, Annemarie C., Beelen, Evelien M.J., Arkenbosch, Jeanine H.C., Erler, Nicole S., Sleutjes, Jasmijn A.M., Hoentjen, Frank, Bodelier, Alexander G.L., Dijkstra, Gerard, Romberg-Camps, Marielle, de Boer, Nanne K., Stassen, Laurents P.S., van der Meulen, Andrea E., West, Rachel, van Ruler, Oddeke, van der Woude, C. Janneke, and de Vries, Annemarie C.

Abstract

BACKGROUND: The advantage of early ileocecal resection after Crohn's disease diagnosis is a matter of debate. This study aims to assess the timing of ileocecal resection on prognosis, after correction for possible confounders. METHODS: Patients with Crohn's disease with primary ileocecal resection between 2000 and 2019 were included in a retrospective multicentre cohort. The primary endpoint was endoscopic recurrence (Rutgeerts score ≥i2b) within 18 months. Secondary endpoints were escalation of inflammatory bowel disease medication within 18 months and re-resection during follow-up. The association between timing of ileocecal resection and these endpoints was investigated using multivariable proportional hazard models, corrected for covariates including Montreal classification, postoperative prophylaxis, smoking, indication for surgery, medication before ileocecal resection, perianal fistulas, surgical approach, histology, length of resected segment and calendar year. RESULTS:In 822 patients ileocecal resection was performed after a median of 3.1 years (i.q.r. 0.7-8.0) after Crohn's disease diagnosis. The lowest incidence of endoscopic recurrence, escalation of inflammatory bowel disease medication and re-resection was observed for patients undergoing ileocecal resection shortly after diagnosis (0-1 months). After correction for covariates, patients with ileocecal resection at 0, 4 and 12 months after diagnosis had a cumulative incidence of 35 per cent, 48 per cent and 39 per cent for endoscopic recurrence, 20 per cent, 29 per cent and 28 per cent for escalation of inflammatory bowel disease medication and 20 per cent, 30 per cent and 34 per cent for re-resection, respectively. In the multivariable model ileocolonic disease (HR 1.39 (95 per cent c.i. 1.05 to 1.86)), microscopic inflammation of proximal and distal resection margins (HR 2.20 (95 per cent c.i. 1.21 to 3.87)) and postoperative prophylactic biol

Published
2023

9. Retreatment with anti-tumor necrosis factor therapy in combination with an immunomodulator for recurrence of Crohn's disease after ileocecal resection results in prolonged continuation as compared to anti-tumor necrosis factor monotherapy

Author

Ten Bokkel Huinink, Sebastiaan, Beelen, Evelien M J, Ten Bokkel Huinink, Thomas, Hoentjen, Frank, G L Bodelier, Alexander, Dijkstra, Gerard, Romberg-Camps, Marielle, de Boer, Nanne K, Stassen, Laurents P S, van der Meulen, Andrea E, West, Rachel, van Ruler, Oddeke, van der Woude, C Janneke, de Vries, Annemarie C, Dutch Initiative on Crohn and Colitis (ICC), Ten Bokkel Huinink, Sebastiaan, Beelen, Evelien M J, Ten Bokkel Huinink, Thomas, Hoentjen, Frank, G L Bodelier, Alexander, Dijkstra, Gerard, Romberg-Camps, Marielle, de Boer, Nanne K, Stassen, Laurents P S, van der Meulen, Andrea E, West, Rachel, van Ruler, Oddeke, van der Woude, C Janneke, de Vries, Annemarie C, and Dutch Initiative on Crohn and Colitis (ICC)

Abstract

BACKGROUND: A considerable proportion of Crohn's disease patients that undergo ileocecal resection (ICR) have failed anti-tumor necrosis factor (TNF) therapy preoperatively. This study aimed to assess the effectiveness of retreatment of anti-TNF therapy in patients with postoperative recurrence.METHODS: A real-world cohort study was performed on Crohn's disease patients who underwent primary ICR after anti-TNF therapy failure, and who were retreated with anti-TNF therapy for postoperative symptomatic Crohn's disease. The primary outcome was treatment failure (the need for (re)introduction of corticosteroids, immunosuppressants, or biologicals or the need for re-resection). Sub-analyses were performed on the nature of preoperative anti-TNF failure (primary non-response, secondary loss of response, intolerance), indication for ICR (refractory, stricturing, penetrating disease), combination therapy with immunomodulators, retreatment with the same anti-TNF agent and preoperative exposure to 1 vs. >1 anti-TNF agents.RESULTS: In total, 66 of 364 patients retreated with anti-TNF therapy following ICR. Cumulative rates of treatment failure at 1 and 2 years were 28% and 47%. Treatment failure rate at 2 years was significantly lower in patients receiving combination therapy as compared to anti-TNF monotherapy (30% vs. 49%, P = 0.02). No difference in treatment failure was found with regards to the nature of preoperative anti-TNF failure (P = 0.76), indication for ICR (P = 0.88) switch of anti-TNF agent (P = 0.55) agent, and preoperative exposure to 1 vs. >1 anti-TNF agents (P = 0.88).CONCLUSION: Retreatment with anti-TNF therapy for postoperative Crohn's disease recurrence is a valid strategy after preoperative failure. Combination therapy is associated with a lower rate of treatment failure.

Published
2023

14. Lower Risk of Recurrence with a Higher Induction Dose of Mesalazine and Longer Duration of Treatment in Ulcerative Colitis: Results from the Dutch, Non-Interventional, IMPACT Study

Author

West, Rachel, primary, Russel, Maurice, primary, Bodelier, Alexander, primary, Kuijvenhoven, Johan, primary, Bruin, Karlien, primary, Jansen, Jeroen, primary, Van der Meulen, Andrea, primary, Keulen, Eric, primary, Wolters, Leonieke, primary, Ouwendijk, Robert, primary, Bezemer, Geert, primary, Koussoulas, Vassilis, primary, Tang, Thjon, primary, Van Dobbenburgh, Aart, primary, Van Nistelrooy, Marianne, primary, Minderhoud, Itta, primary, Vandebosch, Sigrid, primary, and Lubbinge, Hans, primary

Published
2022
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15. Indications, Postoperative Management, and Long-term Prognosis of Crohn’s Disease After Ileocecal Resection: A Multicenter Study Comparing the East and West

Author

Arkenbosch, Jeanine H C, primary, Mak, Joyce W Y, additional, Ho, Jacky C L, additional, Beelen, Evelien M J, additional, Erler, Nicole S, additional, Hoentjen, Frank, additional, Bodelier, Alexander G L, additional, Dijkstra, Gerard, additional, Romberg-Camps, Mariëlle, additional, de Boer, Nanne K H, additional, Stassen, Laurents P S, additional, van der Meulen, Andrea E, additional, West, Rachel, additional, van Ruler, Oddeke, additional, van der Woude, Christien Janneke, additional, Ng, Siew C, additional, and de Vries, Annemarie C, additional

Published
2021
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16. Decreasing Trends in Intestinal Resection and Re-Resection in Crohn's Disease A Nationwide Cohort Study: A Nationwide Cohort Study

Author

Beelen, Evelien M J, van der Woude, C Janneke, Pierik, Marie J, Hoentjen, Frank, de Boer, Nanne K, Oldenburg, Bas, van der Meulen, Andrea E, Ponsioen, Cyriel I J, Dijkstra, Gerard, Bruggink, Annette H, Erler, Nicole S, Schouten, W Rudolph, de Vries, Annemarie C, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), and Groningen Institute for Organ Transplantation (GIOT)

Subjects
surgery, time trends, inflammatory bowel disease, ileocecal resection
Abstract

OBJECTIVE: To assess time trends in intestinal resection and re-resection in Crohn's disease (CD) patients. SUMMARY OF BACKGROUND DATA: CD treatment has changed considerably over the past decades. The effect of these advances on the necessity of intestinal resections and the risk of re-resection is unclear. METHODS: In this nationwide cohort study, adult CD patients with ileocolonic, small bowel, colon, or rectum resections between 1991 and 2015 were included. Data were retrieved from the Dutch nationwide network and registry of histopathology and cytopathology (PALGA). Time trends were analyzed with a broken stick model and Cox proportional hazard model with smoothing splines. RESULTS: The identified cohort comprised 8172 CD patients (3293/4879 male/female) in whom 10,315 intestinal resections were performed. The annual intestinal resection rate decreased nonlinearly from 22.7/100,000 CD patients (1991) to 2.5/100,000 (2015). A significantly steeper decrease was observed before 1999 (slope -1.56) as compared to subsequent years (slope -0.41) (P < 0.001). Analogous trends were observed for ileocolonic, small bowel, and colon resections. Overall cumulative risk of re-resection was 10.9% at 5 years, 18.6% at 10 years, and 28.3% at 20 years after intestinal resection. The hazard for intestinal re-resection showed a nonlinear decreasing trend, with hazard ratio 0.39 (95% confidence interval 0.36-0.44) in 2000 and hazard ratio 0.25 (95% confidence interval 0.18-0.34) in 2015 as compared to 1991. CONCLUSION: Over the past 25 years, intestinal resection rate has decreased significantly for ileocolonic, small bowel, and colonic CD. In addition, current postoperative CD patients are at 75% lower risk of intestinal re-resection.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

Published
2021

17. Real‐world experience of switching from intravenous to subcutaneous vedolizumab maintenance treatment for inflammatory bowel diseases.

Author

Volkers, Adriaan, Straatmijer, Tessa, Duijvestein, Marjolijn, Sales, Amber, Levran, Amit, van Schaik, Fiona, Maljaars, Jeroen, Gecse, Krisztina, Ponsioen, Cyriel, Grootjans, Joep, Hanzel, Jurij, Tack, Greetje, Jansen, Jeroen, Hoentjen, Frank, de Boer, Nanne, van der Marel, Sander, Dijkstra, Gerard, Oldenburg, Bas, Löwenberg, Mark, and van der Meulen, Andrea

Subjects
INFLAMMATORY bowel diseases, CROHN'S disease, VEDOLIZUMAB, ULCERATIVE colitis
Abstract

Summary: Background: Subcutaneous (SC) vedolizumab is effective in inflammatory bowel diseases (IBD) when administered after induction with two infusions. Aim: To assess the effectiveness, safety and pharmacokinetics of a switch from intravenous (IV) to SC maintenance vedolizumab in patients with IBD Methods: In this prospective cohort study, patients with IBD who had ≥4 months IV vedolizumab were switched to SC vedolizumab. We studied the time to discontinuation of SC vedolizumab, adverse events (AEs), changes in clinical and biochemical outcomes and vedolizumab concentrations at baseline, and weeks 12 and 24. Results: We included 82 patients with Crohn's disease (CD) and 53 with ulcerative colitis (UC). Eleven (13.4%) patients with CD and five (9.4%) with UC discontinued SC vedolizumab after a median of 18 (IQR 8–22) and 6 weeks (IQR 5–10), respectively. Four patients with CD switched to a different drug due to loss of response, nine switched back to IV vedolizumab due to adverse events, and three due to needle fear. Common AEs were injection site reactions (n = 15) and headache (n = 6). Median clinical and biochemical disease activity remained stable after the switch. Median serum vedolizumab concentrations increased from 19 μg/ml at the time of the switch to 31 μg/ml 12 weeks after the switch (p < 0.005). Conclusions: Switching from IV to SC vedolizumab maintenance treatment is effective in patients with CD or UC. However, 9% of patients were switched back to IV vedolizumab due to adverse events or fear of needles. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Switching From Reference Infliximab to Biosimilar CT-P13 Did Not Change Quality of Life in Stable Inflammatory Bowel Disease Patients

Author

Pierik, Marieke J, primary, van der Meulen, Andrea E, additional, Van der Linde, Klaas, additional, Lutgens, Maurice, additional, Kuijvenhoven, Johan P, additional, Akol, Halil, additional, Klompmaker, Ids J, additional, Sikkens, Michelle S G, additional, van Megen, Yvonne J B, additional, Stoop, Corinne M, additional, Bloemsaat-Minekus, Joanne P J, additional, and Dijkstra, Gerard, additional

Published
2021
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22. Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Author

MS MDL 1, Infection & Immunity, Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C, Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y, Jansen, Jeroen M, van der Meulen, Andrea E, Beukers, Ruud, Brink, Menno A, Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P, Naber, Ton H, Verhagen, Marc A, de Boer, Nanne K H, Mulder, Chris J J, Dutch Initiative on Crohn and Colitis (ICC), MS MDL 1, Infection & Immunity, Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C, Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y, Jansen, Jeroen M, van der Meulen, Andrea E, Beukers, Ruud, Brink, Menno A, Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P, Naber, Ton H, Verhagen, Marc A, de Boer, Nanne K H, Mulder, Chris J J, and Dutch Initiative on Crohn and Colitis (ICC)

Published
2019

23. Decreasing Trends in Intestinal Resection and Re-Resection in Crohn's Disease

Author

Beelen, Evelien M. J., primary, van der Woude, C. Janneke, additional, Pierik, Marie J., additional, Hoentjen, Frank, additional, de Boer, Nanne K., additional, Oldenburg, Bas, additional, van der Meulen, Andrea E., additional, Ponsioen, Cyriel I. J., additional, Dijkstra, Gerard, additional, Bruggink, Annette H., additional, Erler, Nicole S., additional, Schouten, W. Rudolph, additional, and de Vries, Annemarie C., additional

Published
2019
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24. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Author

Goyette, Philippe, Boucher, Gabrielle, Mallon, Dermot, Ellinghaus, Eva, Jostins, Luke, Huang, Hailiang, Ripke, Stephan, Gusareva, Elena S., Annese, Vito, Hauser, Stephen L., Oksenberg, Jorge R., Thomsen, Ingo, Leslie, Stephen, Daly, Mark J., Van Steen, Kristel, Duerr, Richard H., Barrett, Jeffrey C., Mcgovern, Dermot P. B., Schumm, L. Philip, Traherne, James A., Carrington, Mary N., Kosmoliaptsis, Vasilis, Karlsen, Tom H., Franke, Andre, Rioux, John D., Abraham, Clara, Achkar, Jean Paul, Ahmad, Tariq, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Balschun, Tobias, Bampton, Peter A., Barclay, Murray, Bayless, Theodore M., Bethge, Johannes, Bis, Joshua C., Bitton, Alain, Brand, Stephan, Brant, Steven R., Buning, Carsten, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Croft, Anthony, D'Amato, Mauro, Danese, Silvio, De Jong, Dirk, De Vos, Martine, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Fransen, Karin, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jurgen, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Xinli, Hu, Hui, Ken Y., Imielinski, Marcin, Ippoliti, Andrew, Jonaitis, Laimas, Kennedy, Nicholas A., Khan, Mohammed Azam, Kiudelis, Gediminas, Kugathasan, Subra, Kupcinskas, Limas, Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Mahy, Gillian, Mansfield, John, Massey, Dunecan, Mathew, Christopher G., Milgrom, Raquel, Mitrovic, Mitja, Montgomery, Grant, Mowat, Craig, Newman, Wwilliam, Aylwin, Ng, Siew C., Ng, Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nothen, Markus, Oikonomou, Ioannis, Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Uros, Prescott, Natalie J., Proctor, Deborah D., Radford Smith, Graham, Rahier, Jean Francois, Raychaudhur, Soumya, Regueiro, Miguel, Rieder, Florian, Roberts, Rebecca, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Schreiber, Stefan, Scott, Regan, Seielstad, Mark, Sharma, Yashoda, Silverberg, Mark S., Simms, Lisa A., Skieceviciene, Jurgita, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sventoraityte, Jurgita, Targan, Stephan R., Taylor, Kirstin M., Ter Velde, Anje, Theatre, Emilie, Torkvist, Leif, Tremelling, Mark, Van Der Meulen, Andrea, Van Sommeren, Suzanne, Vasiliauskas, Eric, Vermeire, Severine, Verspaget, Hein W., Walters, Thomas, Wwang, Kai, Wwang, Ming Hsi, Wweersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Xavier, Ramnik J., Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wwei, Zhao, Hongyu, Zhao, Zhen Z., Gastroenterology and Hepatology, Traherne, James [0000-0002-6003-8559], Kosmoliaptsis, Vasilis [0000-0001-7298-1387], and Apollo - University of Cambridge Repository

Subjects
Heterozygote, Genotype, Genotyping Techniques, Genetic Linkage, Ulcerative, Human leukocyte antigen, Biology, Major histocompatibility complex, Polymorphism, Single Nucleotide, Article, Primary sclerosing cholangitis, Major Histocompatibility Complex, Alleles, Chromosome Mapping, Colitis, Ulcerative, Crohn Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-DRB1 Chains, Humans, Inflammatory Bowel Diseases, Phenotype, Genetics, medicine, HLA-DR, Polymorphism, Colitis, HLA-DRB1, Crohn's disease, Single Nucleotide, medicine.disease, Ulcerative colitis, digestive system diseases, Immunology, biology.protein
Abstract

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.

Published
2015

25. Mo1896 - Ustekinumab for Crohn's Disease: A Nationwide Real-Life Observational Cohort Study (ICC Case Series)

Author

Biemans, Vince, primary, Van Der Meulen, Andrea, additional, Van Der Woude, Christien Janneke, additional, de Boer, Nanne, additional, Dijkstra, Gerard, additional, Oldenburg, Bas, additional, Ponsioen, Cyriel, additional, Maljaars, Jeroen, additional, Haans, Jeoffrey, additional, Pierik, Marie, additional, and Hoentjen, Frank, additional

Published
2018
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26. 818 - Tacrolimus Suppositories as Induction Therapy for Refractory Ulcerative Proctitis: A Randomized Controlled Trial

Author

Kreijne, Joany E., primary, Lie, Mitchell R., additional, Dijkstra, Gerard, additional, Löwenberg, Mark, additional, Van Assche, Gert A., additional, West, Rachel, additional, van Noord, Desirée, additional, Van Der Meulen, Andrea, additional, Hansen, Bettina, additional, de Vries, Annemarie C., additional, and Van Der Woude, Christien Janneke, additional

Published
2018
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27. Sa1738 - Thiopurines Versus Anti-TNFα for the Prevention of Postoperative Recurrence in Crohn's Disease - A Metaanalsyis

Author

Beelen, Evelien, primary, Oldenburg, Bas, additional, Van Der Meulen, Andrea, additional, Ponsioen, Cyriel, additional, Dijkstra, Gerard, additional, Pierik, Marie, additional, Hoentjen, Frank, additional, de Boer, Nanne, additional, Erler, Nicole S., additional, Van Der Woude, Christien Janneke, additional, and de Vries, Annemarie C., additional

Published
2018
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28. 604 - Consecutive Negative Findings on Colonoscopy During Surveillance Predict a Low Risk of Advanced Neoplasia in Patients with Longstanding Colitis: Results of a 15-Year Multicenter, Multinational Cohort Study

Author

Shah, Shailja, primary, Ten Hove, Joren, additional, Shaffer, Seth, additional, Bernstein, Charles N., additional, Castaneda, Daniel, additional, Palmela, Carolina, additional, Mooiweer, Erik, additional, Elman, Jordan, additional, Kumar, Akash, additional, Axelrad, Jordan, additional, Glass, Jason, additional, Ullman, Thomas A., additional, Colombel, Jean Frederic, additional, Torres, Joana, additional, van Bodegraven, Adriaan A., additional, Hoentjen, Frank, additional, Jansen, Jeroen, additional, de Jong, Michiel E., additional, Mahmmod, Nofel, additional, Van Der Meulen, Andrea, additional, Ponsioen, Cyriel, additional, Van Der Woude, Christien Janneke, additional, Itzkowitz, Steven, additional, and Oldenburg, Bas, additional

Published
2018
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29. Mo1884 - Drug Survival of Vedolizumab-Treated Inflammatory Bowel Disease Patients in a Nationwide Observational Cohort Study: ICC Case Series

Author

Biemans, Vince, primary, Van Der Woude, Christien Janneke, additional, Dijkstra, Gerard, additional, Van Der Meulen, Andrea, additional, Oldenburg, Bas, additional, de Boer, Nanne, additional, Ponsioen, Cyriel, additional, de Vries, Annemarie C., additional, Haans, Jeoffrey, additional, Pierik, Marie, additional, and Hoentjen, Frank, additional

Published
2018
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30. Telemedicine Enables a Safe Shift from Examination Room Based Care to Personalized Care for Inflammatory Bowel Disease: A Pragmatic Randomized Multicenter Trial With Myibdcoach

Author

de Jong, Marin, primary, Van Der Meulen, Andrea, additional, Romberg-Camps, Marielle, additional, Becx, Marco, additional, Cilissen, Mia, additional, Maljaars, Jeroen, additional, van Bodegraven, Ad, additional, Mahmmod, Nofel, additional, Markus-de Kwaadsteniet, M.L., additional, Hameeteman, Wim, additional, Dijkstra, Gerard, additional, Masclee, Ad, additional, Boonen, Annelies, additional, Jonkers, Daisy, additional, van Tubergen, Astrid, additional, and Pierik, Marie, additional

Published
2017
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31. Postoperative Surgical Recurrence in Crohn's Disease Decreases Significantly in the Biologic ERA

Author

Beelen, Evelien, primary, Schouten, Willem R., additional, Oldenburg, Bas, additional, Van Der Meulen, Andrea, additional, Ponsioen, Cyriel, additional, Dijkstra, Gerard, additional, Pierik, Marie, additional, De Jong, Dirk J., additional, de Boer, Nanne, additional, Van Der Woude, Christien Janneke, additional, and de Vries, Annemarie C., additional

Published
2017
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32. Endoscopic Bowel Injections of Mesenchymal Stromal Cells Alleviate Experimental Colitis

Author

Barnhoorn, Marieke C., primary, de Jonge-Muller, Eveline, additional, Mieremet-Ooms, Marij, additional, van der Helm, Danny, additional, van Gulijk, Mandy, additional, Hoogenboom, Jorinde, additional, Molendijk, Ilse, additional, Maljaars, Jeroen, additional, Van Der Meulen, Andrea, additional, Hawinkels, Lukas, additional, and Verspaget, Hein W., additional

Published
2017
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33. Off‐label prescriptions of drugs used for the treatment of Crohn's disease or ulcerative colitis.

Author

Simsek, Melek, van Riswijk, Milou L. M., Verschuren, Sander, de Boer, Nanne K. H., Lissenberg‐Witte, Birgit I., Hoentjen, Frank, Oldenburg, Bas, Ponsioen, Cyriel Y., van der Woude, C. Janneke, van der Meulen, Andrea E., Pierik, Marieke, and Dijkstra, Gerard

Subjects
DRUG prescribing, OFF-label use (Drugs), ULCERATIVE colitis, DATA analysis
Abstract

Background: Off‐label prescribing is encountered across various fields of medicine and creates alternative treatment options, but is associated with unknown safety risks. The use of off‐label drugs for the treatment of patients with inflammatory bowel diseases (IBD) has not been characterised before. Aim: To assess the proportion and characteristics of off‐label prescribing for IBD in tertiary care centres in the Netherlands. Methods: A prospective database of IBD patients from all Dutch university hospitals was used to collect data on drug prescriptions for IBD and demographics. Drugs were classified as off‐label if they were unlicensed for Crohn's disease and/or ulcerative colitis by the Medicines Evaluation Board. Uni‐ and multivariable analyses were used to identify patient‐specific characteristics predictive of increased off‐label use. Results: For the induction and/or maintenance treatment of 4583 IBD patients, 12 651 historical and current drug records were available in the database. Of these, 2374 (19%) were considered off‐label prescriptions. Out of 4583 IBD patients, 1477 (32%) were exposed to off‐label drugs. Commonly prescribed off‐label IBD drugs were mercaptopurine (18%), beclomethasone (12%), thioguanine (4%) and allopurinol (3%). Non‐thiopurine/methotrexate off‐label drugs were prescribed in 243 patients (6%), including biological agents or tofacitinib in 47 IBD patients (1%). Off‐label prescriptions were more common in ulcerative colitis than Crohn's disease (37% vs 29%, P < 0.001). Smokers and patients that received ≥5 drug types during their disease course were more likely to be exposed to off‐label drugs (smoking 33% vs 27% and multiple drug use 66% vs 22%, both P < 0.001). Conclusion: About one‐fifth of prescriptions for IBD were off‐label and one‐third of IBD patients, especially ulcerative colitis patients, were exposed to off‐label drugs. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Mo1838 First Results and Information Model From the Parelsnoer Institute IBD Biobank: A Nationwide Standardized Inflammatory Bowel Disease Collection by All University Medical Centers in the Netherlands

Author

Spekhorst, Lieke M., primary, Imhann, Floris, additional, Festen, Eleonora A., additional, van bodegraven, A., additional, de Boer, Nanne, additional, Bouma, Gerd, additional, Fidder, Herma H., additional, D'Haens, Geert R., additional, Hoentjen, Frank, additional, Hommes, Daniel, additional, De Jong, Dirk J., additional, Löwenberg, Mark, additional, van der Meulen, Andrea, additional, Oldenburg, Bas, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Stokkers, P., additional, Visschedijk, Marijn C., additional, van der Woude, Christien Janneke, additional, Dijkstra, Gerard, additional, and Weersma, Rinse K., additional

Published
2016
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38. Su1801 One Simple Question Is Sufficient for Measuring Medication Adherence in Inflammatory Bowel Disease Patients Using Self-Report

Author

Severs, Mirjam, primary, Mangen, Marie-Josée J., additional, Fidder, Herma H., additional, Van Der Valk, Mirthe E., additional, Van Der Have, Mike, additional, Van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, Van Der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, Van Der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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39. Sa1944 Non-Adherence to Medical Therapy Is Associated With Hospitalizations and the Development of Active Disease in Inflammatory Bowel Disease

Author

Severs, Mirjam, primary, Fidder, Herma H., additional, Mangen, Marie-Josée J., additional, van der Valk, Mirthe E., additional, van der Have, Mike, additional, van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, van der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, van der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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40. Su1853 Identification of a Genetic Risk Variant in the WWOX Gene Associated With Recurrent Fibrostenotic Crohn's Disease

Author

Visschedijk, Marijn C., primary, Spekhorst, Lieke M., additional, Dijkstra, Gerard, additional, Van Loo, Ellen S., additional, De Jong, Dirk J., additional, Van Der Meulen, Andrea, additional, Verspaget, Hein W., additional, Ponsioen, Cyriel, additional, Nieuwenhuijs, Vincent B., additional, Oldenburg, Bas, additional, Pierik, Marie, additional, de Boer, Nanne, additional, Van Der Woude, Christien Janneke, additional, Imhann, Floris, additional, Alberts, Rudi, additional, Van sommeren, Suzanne, additional, Faber, Klaas Nico, additional, Aldaz, C.M., additional, Weersma, Rinse K., additional, and Festen, Eleonora A., additional

Published
2016
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41. Su1854 Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Population Suggests Population-Specific Association of Rare Variants in MUC2

Author

Visschedijk, Marijn C., primary, Alberts, Rudi, additional, Mucha, Soren, additional, Deelen, Patrick, additional, De Jong, Dirk J., additional, Pierik, Marie, additional, Van Der Meulen, Andrea, additional, Van Der Woude, Christien Janneke, additional, Van bodegraven, A., additional, Oldenburg, Bas, additional, Löwenberg, Mark, additional, Dijkstra, Gerard, additional, Ellinghaus, David, additional, Schreiber, Stefan, additional, Wijmenga, Cisca, additional, Rivas, Manuel A., additional, Franke, Andre, additional, Van Diemen, Cleo, additional, and Weersma, Rinse K., additional

Published
2016
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42. Sa1945 Lower Quality of Life, More Active Disease and Increased Healthcare Costs Due to Non-Adherence in Inflammatory Bowel Disease

Author

Severs, Mirjam, primary, Mangen, Marie-Josée J., additional, Fidder, Herma H., additional, van der Valk, Mirthe E., additional, van der Have, Mike, additional, van Bodegraven, Adriaan A., additional, Clemens, Cees H., additional, Dijkstra, Gerard, additional, Jeroen, M, additional, De Jong, Dirk J., additional, Mahmmod, Nofel, additional, van de Meeberg, Paul C., additional, van der Meulen, Andrea, additional, Pierik, Marie, additional, Ponsioen, Cyriel, additional, Romberg-Camps, Marielle, additional, Siersema, Peter D., additional, Vermeijden, Reinoud J., additional, van der Woude, Christien Janneke, additional, Zuithoff, Peter N., additional, and Oldenburg, Bas, additional

Published
2016
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43. Multimodal treatment of perianal fistulas in Crohn's disease : Seton versus anti-TNF versus advancement plasty (PISA): Study protocol for a randomized controlled trial

Author

de Groof, E. Joline, Buskens, Christianne J., Ponsioen, Cyriel Y., Dijkgraaf, Marcel G W, D'Haens, Geert R A M, Srivastava, Nidhi, van Acker, Gijs J D, Jansen, Jeroen M., Gerhards, Michael F., Dijkstra, Gerard, Lange, Johan F M, Witteman, Ben J M, Kruyt, Philip M., Pronk, Apollo, van Tuyl, Sebastiaan A C, Bodelier, Alexander, Crolla, Rogier M P H, West, Rachel L., Vrijland, Wietske W., Consten, Esther C J, Brink, Menno A., Tuynman, Jurriaan B., de Boer, Nanne K H, Breukink, Stephanie O., Pierik, Marieke J., Oldenburg, Bas, van der Meulen, Andrea E., Bonsing, Bert A., Spinelli, Antonino, Danese, Silvio, Sacchi, Matteo, Warusavitarne, Janindra, Hart, Ailsa, Yassin, Nuha A., Kennelly, Rory P., Cullen, Garret J., Winter, Desmond C., Hawthorne, A. Barney, Torkington, Jared, Bemelman, Willem A., de Groof, E. Joline, Buskens, Christianne J., Ponsioen, Cyriel Y., Dijkgraaf, Marcel G W, D'Haens, Geert R A M, Srivastava, Nidhi, van Acker, Gijs J D, Jansen, Jeroen M., Gerhards, Michael F., Dijkstra, Gerard, Lange, Johan F M, Witteman, Ben J M, Kruyt, Philip M., Pronk, Apollo, van Tuyl, Sebastiaan A C, Bodelier, Alexander, Crolla, Rogier M P H, West, Rachel L., Vrijland, Wietske W., Consten, Esther C J, Brink, Menno A., Tuynman, Jurriaan B., de Boer, Nanne K H, Breukink, Stephanie O., Pierik, Marieke J., Oldenburg, Bas, van der Meulen, Andrea E., Bonsing, Bert A., Spinelli, Antonino, Danese, Silvio, Sacchi, Matteo, Warusavitarne, Janindra, Hart, Ailsa, Yassin, Nuha A., Kennelly, Rory P., Cullen, Garret J., Winter, Desmond C., Hawthorne, A. Barney, Torkington, Jared, and Bemelman, Willem A.

Published
2015

44. Multimodal treatment of perianal fistulas in Crohn's disease: Seton versus anti-TNF versus advancement plasty (PISA): Study protocol for a randomized controlled trial

Author

UMC Utrecht, MS MDL 1, Infection & Immunity, de Groof, E. Joline, Buskens, Christianne J., Ponsioen, Cyriel Y., Dijkgraaf, Marcel G W, D'Haens, Geert R A M, Srivastava, Nidhi, van Acker, Gijs J D, Jansen, Jeroen M., Gerhards, Michael F., Dijkstra, Gerard, Lange, Johan F M, Witteman, Ben J M, Kruyt, Philip M., Pronk, Apollo, van Tuyl, Sebastiaan A C, Bodelier, Alexander, Crolla, Rogier M P H, West, Rachel L., Vrijland, Wietske W., Consten, Esther C J, Brink, Menno A., Tuynman, Jurriaan B., de Boer, Nanne K H, Breukink, Stephanie O., Pierik, Marieke J., Oldenburg, Bas, van der Meulen, Andrea E., Bonsing, Bert A., Spinelli, Antonino, Danese, Silvio, Sacchi, Matteo, Warusavitarne, Janindra, Hart, Ailsa, Yassin, Nuha A., Kennelly, Rory P., Cullen, Garret J., Winter, Desmond C., Hawthorne, A. Barney, Torkington, Jared, Bemelman, Willem A., UMC Utrecht, MS MDL 1, Infection & Immunity, de Groof, E. Joline, Buskens, Christianne J., Ponsioen, Cyriel Y., Dijkgraaf, Marcel G W, D'Haens, Geert R A M, Srivastava, Nidhi, van Acker, Gijs J D, Jansen, Jeroen M., Gerhards, Michael F., Dijkstra, Gerard, Lange, Johan F M, Witteman, Ben J M, Kruyt, Philip M., Pronk, Apollo, van Tuyl, Sebastiaan A C, Bodelier, Alexander, Crolla, Rogier M P H, West, Rachel L., Vrijland, Wietske W., Consten, Esther C J, Brink, Menno A., Tuynman, Jurriaan B., de Boer, Nanne K H, Breukink, Stephanie O., Pierik, Marieke J., Oldenburg, Bas, van der Meulen, Andrea E., Bonsing, Bert A., Spinelli, Antonino, Danese, Silvio, Sacchi, Matteo, Warusavitarne, Janindra, Hart, Ailsa, Yassin, Nuha A., Kennelly, Rory P., Cullen, Garret J., Winter, Desmond C., Hawthorne, A. Barney, Torkington, Jared, and Bemelman, Willem A.

Published
2015

45. Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial

Author

de Groof, E. Joline, primary, Buskens, Christianne J., additional, Ponsioen, Cyriel Y., additional, Dijkgraaf, Marcel G. W., additional, D’Haens, Geert R. A. M., additional, Srivastava, Nidhi, additional, van Acker, Gijs J. D., additional, Jansen, Jeroen M., additional, Gerhards, Michael F., additional, Dijkstra, Gerard, additional, Lange, Johan F. M., additional, Witteman, Ben J. M., additional, Kruyt, Philip M., additional, Pronk, Apollo, additional, van Tuyl, Sebastiaan A. C., additional, Bodelier, Alexander, additional, Crolla, Rogier M. P. H., additional, West, Rachel L., additional, Vrijland, Wietske W., additional, Consten, Esther C. J., additional, Brink, Menno A., additional, Tuynman, Jurriaan B., additional, de Boer, Nanne K. H., additional, Breukink, Stephanie O., additional, Pierik, Marieke J., additional, Oldenburg, Bas, additional, van der Meulen, Andrea E., additional, Bonsing, Bert A., additional, Spinelli, Antonino, additional, Danese, Silvio, additional, Sacchi, Matteo, additional, Warusavitarne, Janindra, additional, Hart, Ailsa, additional, Yassin, Nuha A., additional, Kennelly, Rory P., additional, Cullen, Garret J., additional, Winter, Desmond C., additional, Hawthorne, A. Barney, additional, Torkington, Jared, additional, and Bemelman, Willem A., additional

Published
2015
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48. 982 - Telemedicine Enables a Safe Shift from Examination Room Based Care to Personalized Care for Inflammatory Bowel Disease: A Pragmatic Randomized Multicenter Trial With Myibdcoach

Author

de Jong, Marin, Van Der Meulen, Andrea, Romberg-Camps, Marielle, Becx, Marco, Cilissen, Mia, Maljaars, Jeroen, van Bodegraven, Ad, Mahmmod, Nofel, Markus-de Kwaadsteniet, M.L., Hameeteman, Wim, Dijkstra, Gerard, Masclee, Ad, Boonen, Annelies, Jonkers, Daisy, van Tubergen, Astrid, and Pierik, Marie

Published
2017
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50. First Results and Information Model From the Parelsnoer Institute IBD Biobank: A Nationwide Standardized Inflammatory Bowel Disease Collection by All University Medical Centers in the Netherlands

Author

Spekhorst, Lieke M., Imhann, Floris, Festen, Eleonora A., van Bodegraven, A., de Boer, Nanne, Bouma, Gerd, Fidder, Herma H., D'Haens, Geert R., Hoentjen, Frank, Hommes, Daniel, de Jong, Dirk J., Lowenberg, Mark, Van der Meulen, Andrea, Oldenburg, Bas, Pierik, Marie, Ponsioen, Cyriel, Stokkers, P., Visschedijk, Marijn C., Van der Woude, Christien Janneke, Dijkstra, Gerard, Weersma, Rinse K., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), and Groningen Institute for Organ Transplantation (GIOT)

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