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1. A Systematic Analysis of the Clinical Outcome Associated with Multiple Reclassified Desmosomal Gene Variants in Arrhythmogenic Right Ventricular Cardiomyopathy Patients

Author

Nagyova, Emilia, Hoorntje, Edgar T., te Rijdt, Wouter P., Bosman, Laurens P., Syrris, Petros, Protonotarios, Alexandros, Elliott, Perry M., Tsatsopoulou, Adalena, Mestroni, Luisa, Taylor, Matthew R. G., Sinagra, Gianfranco, Merlo, Marco, Wada, Yuko, Horie, Minoru, Mogensen, Jens, Christensen, Alex H., Gerull, Brenda, Song, Lei, Yao, Yan, Fan, Siyang, Saguner, Ardan M., Duru, Firat, Koskenvuo, Juha W., Cruz Marino, Tania, Tichnell, Crystal, Judge, Daniel P., Dooijes, Dennis, Lekanne Deprez, Ronald H., Basso, Cristina, Pilichou, Kalliopi, Bauce, Barbara, Wilde, Arthur A. M., Charron, Philippe, Fressart, Véronique, van der Heijden, Jeroen F., van den Berg, Maarten P., Asselbergs, Folkert W., James, Cynthia A., Jongbloed, Jan D. H., Harakalova, Magdalena, and van Tintelen, J. Peter

Published
2023
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3. Clinical Characteristics and Follow-Up of Pediatric-Onset Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Roudijk, Robert W., Verheul, Lisa, Bosman, Laurens P., Bourfiss, Mimount, Breur, Johannes M.P.J., Slieker, Martijn G., Blank, Andreas C., Dooijes, Dennis, van der Heijden, Jeroen F., van den Heuvel, Freek, Clur, Sally-Ann, Udink ten Cate, Floris E.A., van den Berg, Maarten P., Wilde, Arthur A.M., Asselbergs, Folkert W., Peter van Tintelen, J., and te Riele, Anneline S.J.M.

Published
2022
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5. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration

Author

Cadrin-Tourigny, Julia, Bosman, Laurens P., Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Lie, Øyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A.M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing-Chien, Van der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D.H., van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N.W., Calkins, Hugh, te Riele, Anneline S.J.M., and James, Cynthia A.

Published
2021
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6. A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

Author

de Brouwer, Remco, primary, te Rijdt, Wouter P, additional, Hoorntje, Edgar T, additional, Amin, Ahmad, additional, Asselbergs, Folkert W, additional, Cox, Moniek G P J, additional, van der Heijden, Jeroen F, additional, Hillege, Hans, additional, Karper, Jacco C, additional, Mahmoud, Belend, additional, van der Meer, Peter, additional, Oomen, Anton, additional, te Riele, Anneline S J M, additional, Silljé, Herman H W, additional, Tan, Hanno L, additional, van Tintelen, Jan Peter, additional, van Veldhuisen, Dirk J, additional, Westenbrink, Berend Daan, additional, Wiesfeld, Ans C P, additional, Willems, Tineke P, additional, van der Zwaag, Paul A, additional, Wilde, Arthur A M, additional, de Boer, Rudolf A, additional, and van den Berg, Maarten P, additional

Published
2023
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8. Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers.

Author

Lopera-Maya, Esteban A., Li, Shuang, de Brouwer, Remco, Nolte, Ilja M., van Breen, Justin, The Netherlands A. C. M./P. L. N. Registry, Bosman, Laurens P., Verstraelen, Tom E., van Lint, Freya H. M., Cox, Moniek G. P. J., Groeneweg, Judith A., Mast, Thomas P., van der Zwaag, Paul A., Volders, Paul G. A., Evertz, Reinder, Wong, Lisa, de Groot, Natasja M. S., Zeppenfeld, Katja, van der Heijden, Jeroen F., and van den Berg, Maarten P.

Abstract

The c.40_42delAGA variant in the phospholamban gene (PLN) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, there are carriers who remain asymptomatic at older ages. To understand the mechanisms behind this incomplete penetrance, we evaluated potential phenotypic and genetic modifiers in 74 PLN:c.40_42delAGA carriers identified in 36,339 participants of the Lifelines population cohort. Asymptomatic carriers (N = 48) showed shorter QRS duration (− 5.73 ms, q value = 0.001) compared to asymptomatic non-carriers, an effect we could replicate in two different independent cohorts. Furthermore, symptomatic carriers showed a higher correlation (rPearson = 0.17) between polygenic predisposition to higher QRS (PGSQRS) and QRS (p value = 1.98 × 10–8), suggesting that the effect of the genetic variation on cardiac rhythm might be increased in symptomatic carriers. Our results allow for improved clinical interpretation for asymptomatic carriers, while our approach could guide future studies on genetic diseases with incomplete penetrance. [ABSTRACT FROM AUTHOR]

Published
2023
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9. A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

Author

de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., van den Berg, Maarten P., de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., and van den Berg, Maarten P.

Abstract

Phospholamban (PLN; p.Arg14del) cardiomyopathy is an inherited disease caused by the pathogenic p.Arg14del variant in the PLN gene. Clinically, it is characterized by malignant ventricular arrhythmias and progressive heart failure.1,2 Cardiac fibrotic tissue remodelling occurs early on in PLN p.Arg14del carriers.3,4 Eplerenone was deemed a treatment candidate because of its beneficial effects on ventricular remodelling and antifibrotic properties.5,6 We conducted the multicentre randomized trial ‘intervention in PHOspholamban RElated CArdiomyopathy STudy’ (i-PHORECAST) to assess whether treatment with eplerenone of asymptomatic PLN p.Arg14del carriers attenuates disease onset and progression.

Published
2023

10. A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

Author

Cardiologie, Team Medisch, Team Onderzoek, Circulatory Health, Onderzoek Device, Genetica, Genetica Groep Van Tintelen, Child Health, de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., van den Berg, Maarten P., Cardiologie, Team Medisch, Team Onderzoek, Circulatory Health, Onderzoek Device, Genetica, Genetica Groep Van Tintelen, Child Health, de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., and van den Berg, Maarten P.

Published
2023

11. A Systematic Analysis of the Clinical Outcome Associated with Multiple Reclassified Desmosomal Gene Variants in Arrhythmogenic Right Ventricular Cardiomyopathy Patients

Author

Arts Assistenten Cardiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Cardiologie, Team Medisch, Onderzoek Precision medicine, Genetica Groep Van Tintelen, Cancer, Child Health, Nagyova, Emilia, Hoorntje, Edgar T, Rijdt, Wouter P Te, Bosman, Laurens P, Syrris, Petros, Protonotarios, Alexandros, Elliott, Perry M, Tsatsopoulou, Adalena, Mestroni, Luisa, Taylor, Matthew R G, Sinagra, Gianfranco, Merlo, Marco, Wada, Yuko, Horie, Minoru, Mogensen, Jens, Christensen, Alex H, Gerull, Brenda, Song, Lei, Yao, Yan, Fan, Siyang, Saguner, Ardan M, Duru, Firat, Koskenvuo, Juha W, Cruz Marino, Tania, Tichnell, Crystal, Judge, Daniel P, Dooijes, Dennis, Lekanne Deprez, Ronald H, Basso, Cristina, Pilichou, Kalliopi, Bauce, Barbara, Wilde, Arthur A M, Charron, Philippe, Fressart, Véronique, van der Heijden, Jeroen F, van den Berg, Maarten P, Asselbergs, Folkert W, James, Cynthia A, Jongbloed, Jan D H, Harakalova, Magdalena, van Tintelen, J Peter, Arts Assistenten Cardiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Cardiologie, Team Medisch, Onderzoek Precision medicine, Genetica Groep Van Tintelen, Cancer, Child Health, Nagyova, Emilia, Hoorntje, Edgar T, Rijdt, Wouter P Te, Bosman, Laurens P, Syrris, Petros, Protonotarios, Alexandros, Elliott, Perry M, Tsatsopoulou, Adalena, Mestroni, Luisa, Taylor, Matthew R G, Sinagra, Gianfranco, Merlo, Marco, Wada, Yuko, Horie, Minoru, Mogensen, Jens, Christensen, Alex H, Gerull, Brenda, Song, Lei, Yao, Yan, Fan, Siyang, Saguner, Ardan M, Duru, Firat, Koskenvuo, Juha W, Cruz Marino, Tania, Tichnell, Crystal, Judge, Daniel P, Dooijes, Dennis, Lekanne Deprez, Ronald H, Basso, Cristina, Pilichou, Kalliopi, Bauce, Barbara, Wilde, Arthur A M, Charron, Philippe, Fressart, Véronique, van der Heijden, Jeroen F, van den Berg, Maarten P, Asselbergs, Folkert W, James, Cynthia A, Jongbloed, Jan D H, Harakalova, Magdalena, and van Tintelen, J Peter

Published
2023

12. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in the Pediatric Population: Clinical Characterization and Comparison With Adult-Onset Disease

Author

te Riele, Anneline S.J.M., James, Cynthia A., Sawant, Abhishek C., Bhonsale, Aditya, Groeneweg, Judith A., Mast, Thomas P., Murray, Brittney, Tichnell, Crystal, Dooijes, Dennis, van Tintelen, J. Peter, Judge, Daniel P., van der Heijden, Jeroen F., Crosson, Jane, Hauer, Richard N.W., Calkins, Hugh, and Tandri, Harikrishna

Published
2015
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15. CE-522-03 LONGITUDINAL PREDICTION OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY

Author

Carrick, Richard, primary, Riele, Anneline Te, additional, Gasperetti, Alessio, additional, Bosman, Laurens P., additional, Cadrin-Tourigny, Julia, additional, Tundo, Fabrizio, additional, Pendleton, Kristin, additional, Tichnell, Crystal, additional, van den berg, nicoline P., additional, van der Heijden, Jeroen F., additional, van Tintelen, Peter, additional, Wilde, Arthur A.M., additional, Yap, Sing-Chien, additional, Zeppenfeld, Katja, additional, Calkins, Hugh, additional, James, Cynthia A., additional, and Wu, Katherine C., additional

Published
2022
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16. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy According to Revised 2010 Task Force Criteria With Inclusion of Non-Desmosomal Phospholamban Mutation Carriers

Author

Groeneweg, Judith A., van der Zwaag, Paul A., Olde Nordkamp, Louise R.A., Bikker, Hennie, Jongbloed, Jan D.H., Jongbloed, Roselie, Wiesfeld, Ans C.P., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Atsma, Douwe E., de Boer, Karin, Doevendans, Pieter A., Vink, Aryan, van Veen, Toon A.B., Dooijes, Dennis, van den Berg, Maarten P., Wilde, Arthur A.M., van Tintelen, J. Peter, and Hauer, Richard N.

Published
2013
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17. A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Author

Cadrin-Tourigny, Julia, Bosman, Laurens P., Nozza, Anna, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Fortier, Annik, Lie, Oyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A. M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing-Chien, van der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D. H., Guertin, Marie-Claude, van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N. W., Calkins, Hugh, te Riele, Anneline S. J. M., James, Cynthia A., Cadrin-Tourigny, Julia, Bosman, Laurens P., Nozza, Anna, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Fortier, Annik, Lie, Oyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A. M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing-Chien, van der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D. H., Guertin, Marie-Claude, van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N. W., Calkins, Hugh, te Riele, Anneline S. J. M., and James, Cynthia A.

Abstract

Aims Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 +/- 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.3% reduction of ICD placements with the same proportion of protected patients (P < 0.001). Conclusion Using the Largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com)., Funding Agencies|Canadian Heart Rhythm Society George Mines Traveling Fellowship; Montreal Heart Institute Foundation; Fondation LeducqLeducq Foundation [16 CVD 02]; Dutch Heart FoundationNetherlands Heart Foundation [2015T058, CVON2015-12 eDETECT, 2012-10 PREDICT]; Netherlands Organisation for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [040.11.586]; Netherlands Heart Institute [06901]; Swiss National Science FoundationSwiss National Science Foundation (SNSF)European Commission [320030_160327]; UMC Utrecht 2017 Alexandre Suerman Stipend; UMC Utrecht Fellowship Clinical Research Talent; European Unions Horizon 2020 research and innovation program under the ERA-NET Co-fund action [680969]; Dr Francis P. Chiaramonte Private Foundation; Leyla Erkan Family Fund for ARVD Research; Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins; Bogle Foundation; Healing Hearts Foundation; Campanella family; Patrick J. Harrison Family; Peter French Memorial Foundation; Wilmerding Endowments; Georg und Bertha Schwyzer-Winiker Foundation; Baugarten Foundation; Swiss Heart Foundation; Leonie-Wild Foundation; Marvin and Philippa Carsley Chair of Medicine; UCL Hospitals NIHR Biomedical Research Centre

Published
2022
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18. Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy

Author

Bosman, Laurens P., Nielsen Gerlach, Claire L., Cadrin-Tourigny, Julia, Orgeron, Gabriela, Tichnell, Crystal, Murray, Brittney, Bourfiss, Mimount, Van Der Heijden, Jeroen F., Yap, Sing Chien, Zeppenfeld, Katja, Van Den Berg, Maarten P., Wilde, Arthur A.M., Asselbergs, Folkert W., Tandri, Hariskrishna, Calkins, Hugh, Van Tintelen, J. Peter, James, Cynthia A., Te Riele, Anneline S.J.M., Bosman, Laurens P., Nielsen Gerlach, Claire L., Cadrin-Tourigny, Julia, Orgeron, Gabriela, Tichnell, Crystal, Murray, Brittney, Bourfiss, Mimount, Van Der Heijden, Jeroen F., Yap, Sing Chien, Zeppenfeld, Katja, Van Den Berg, Maarten P., Wilde, Arthur A.M., Asselbergs, Folkert W., Tandri, Hariskrishna, Calkins, Hugh, Van Tintelen, J. Peter, James, Cynthia A., and Te Riele, Anneline S.J.M.

Abstract

Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have an increased risk of ventricular arrhythmias (VA). Four implantable cardioverter-defibrillator (ICD) recommendation algorithms are available The International Task Force Consensus ('ITFC'), an ITFC modification by Orgeron et al. ('mITFC'), the AHA/HRS/ACC guideline for VA management ('AHA'), and the HRS expert consensus statement ('HRS'). This study aims to validate and compare the performance of these algorithms in ARVC. Methods and results: We classified 617 definite ARVC patients (38.5 ± 15.1 years, 52.4% male, 39.2% prior sustained VA) according to four algorithms. Clinical performance was evaluated by sensitivity, specificity, ROC-analysis, and decision curve analysis for any sustained VA and for fast VA (>250 b.p.m.). During 6.4 [2.8-11.5] years follow-up, 282 (45.7%) patients experienced any sustained VA, and 63 (10.2%) fast VA. For any sustained VA, ITFC and mITFC provide higher sensitivity than AHA and HRS (94.0-97.8% vs. 76.7-83.5%), but lower specificity (15.9-32.0% vs. 42.7%-60.1%). Similarly, for fast VA, ITFC and mITFC provide higher sensitivity than AHA and HRS (95.2-97.1% vs. 76.7-78.4%) but lower specificity (42.7-43.1 vs. 76.7-78.4%). Decision curve analysis showed ITFC and mITFC to be superior for a 5-year sustained VA risk ICD indication threshold between 5-25% or 2-9% for fast VA. Conclusion: The ITFC and mITFC provide the highest protection rates, whereas AHA and HRS decrease unnecessary ICD placements. ITFC or mITFC should be used if we consider the 5-year threshold for ICD indication to lie within 5-25% for sustained VA or 2-9% for fast VA. These data will inform decision-making for ICD placement in ARVC.

Published
2022

19. A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Author

Arts Assistenten Cardiologie, Cardiologie zorg, Team Medisch, Circulatory Health, Genetica Groep Van Tintelen, Cancer, Child Health, Genetica, Onderzoek Precision medicine, Cadrin-Tourigny, Julia, Bosman, Laurens P., Nozza, Anna, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Fortier, Annik, Lie, Øyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, Van Den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A.M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing Chien, Van Der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D.H., Guertin, Marie Claude, Van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N.W., Calkins, Hugh, Te Riele, Anneline S.J.M., James, Cynthia A., Arts Assistenten Cardiologie, Cardiologie zorg, Team Medisch, Circulatory Health, Genetica Groep Van Tintelen, Cancer, Child Health, Genetica, Onderzoek Precision medicine, Cadrin-Tourigny, Julia, Bosman, Laurens P., Nozza, Anna, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Fortier, Annik, Lie, Øyvind H., Saguner, Ardan M., Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, Van Den Berg, Maarten P., Asselbergs, Folkert W., Wilde, Arthur A.M., Krahn, Andrew D., Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L., Kamel, Ihab R., Crosson, Jane E., Judge, Daniel P., Yap, Sing Chien, Van Der Heijden, Jeroen F., Tandri, Harikrishna, Jongbloed, Jan D.H., Guertin, Marie Claude, Van Tintelen, J. Peter, Platonov, Pyotr G., Duru, Firat, Haugaa, Kristina H., Khairy, Paul, Hauer, Richard N.W., Calkins, Hugh, Te Riele, Anneline S.J.M., and James, Cynthia A.

Published
2022

20. Clinical Characteristics and Follow-Up of Pediatric-Onset Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Electrofysiologie, CCU Cardiologie, Team Onderzoek, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, Genetica, Genetica Sectie Genoomdiagnostiek, Team Medisch, Cancer, Roudijk, Robert W., Verheul, Lisa, Bosman, Laurens P., Bourfiss, Mimount, Breur, Johannes M.P.J., Slieker, Martijn G., Blank, Andreas C., Dooijes, Dennis, van der Heijden, Jeroen F., van den Heuvel, Freek, Clur, Sally Ann, Udink ten Cate, Floris E.A., van den Berg, Maarten P., Wilde, Arthur A.M., Asselbergs, Folkert W., Peter van Tintelen, J., te Riele, Anneline S.J.M., Electrofysiologie, CCU Cardiologie, Team Onderzoek, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, Genetica, Genetica Sectie Genoomdiagnostiek, Team Medisch, Cancer, Roudijk, Robert W., Verheul, Lisa, Bosman, Laurens P., Bourfiss, Mimount, Breur, Johannes M.P.J., Slieker, Martijn G., Blank, Andreas C., Dooijes, Dennis, van der Heijden, Jeroen F., van den Heuvel, Freek, Clur, Sally Ann, Udink ten Cate, Floris E.A., van den Berg, Maarten P., Wilde, Arthur A.M., Asselbergs, Folkert W., Peter van Tintelen, J., and te Riele, Anneline S.J.M.

Published
2022

21. Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy

Author

Aios en Stafsecr. Cardiologie, Onderzoek Precision medicine, Team Medisch, Circulatory Health, Genetica, Arts Assistenten Cardiologie, Bosman, Laurens P, Nielsen Gerlach, Claire L, Cadrin-Tourigny, Julia, Orgeron, Gabriela, Tichnell, Crystal, Murray, Brittney, Bourfiss, Mimount, van der Heijden, Jeroen F, Yap, Sing-Chien, Zeppenfeld, Katja, van den Berg, Maarten P, Wilde, Arthur A M, Asselbergs, Folkert W, Tandri, Hariskrishna, Calkins, Hugh, van Tintelen, J Peter, James, Cynthia A, Te Riele, Anneline S J M, Aios en Stafsecr. Cardiologie, Onderzoek Precision medicine, Team Medisch, Circulatory Health, Genetica, Arts Assistenten Cardiologie, Bosman, Laurens P, Nielsen Gerlach, Claire L, Cadrin-Tourigny, Julia, Orgeron, Gabriela, Tichnell, Crystal, Murray, Brittney, Bourfiss, Mimount, van der Heijden, Jeroen F, Yap, Sing-Chien, Zeppenfeld, Katja, van den Berg, Maarten P, Wilde, Arthur A M, Asselbergs, Folkert W, Tandri, Hariskrishna, Calkins, Hugh, van Tintelen, J Peter, James, Cynthia A, and Te Riele, Anneline S J M

Published
2022

22. Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis

Author

te Riele, Anneline S.J.M., Agullo-Pascual, Esperanza, James, Cynthia A., Leo-Macias, Alejandra, Cerrone, Marina, Zhang, Mingliang, Lin, Xianming, Lin, Bin, Sobreira, Nara L., Amat-Alarcon, Nuria, Marsman, Roos F., Murray, Brittney, Tichnell, Crystal, van der Heijden, Jeroen F., Dooijes, Dennis, van Veen, Toon A.B., Tandri, Harikrishna, Fowler, Steven J., Hauer, Richard N.W., Tomaselli, Gordon, van den Berg, Maarten P., Taylor, Matthew R.G., Brun, Francesca, Sinagra, Gianfranco, Wilde, Arthur A.M., Mestroni, Luisa, Bezzina, Connie R., Calkins, Hugh, Peter van Tintelen, J., Bu, Lei, Delmar, Mario, and Judge, Daniel P.

Published
2017
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23. A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Author

Cadrin-Tourigny, Julia, primary, Bosman, Laurens P, additional, Nozza, Anna, additional, Wang, Weijia, additional, Tadros, Rafik, additional, Bhonsale, Aditya, additional, Bourfiss, Mimount, additional, Fortier, Annik, additional, Lie, Øyvind H, additional, Saguner, Ardan M, additional, Svensson, Anneli, additional, Andorin, Antoine, additional, Tichnell, Crystal, additional, Murray, Brittney, additional, Zeppenfeld, Katja, additional, van den Berg, Maarten P, additional, Asselbergs, Folkert W, additional, Wilde, Arthur A M, additional, Krahn, Andrew D, additional, Talajic, Mario, additional, Rivard, Lena, additional, Chelko, Stephen, additional, Zimmerman, Stefan L, additional, Kamel, Ihab R, additional, Crosson, Jane E, additional, Judge, Daniel P, additional, Yap, Sing Chien, additional, van der Heijden, Jeroen F, additional, Tandri, Harikrishna, additional, Jongbloed, Jan D H, additional, Guertin, Marie Claude, additional, van Tintelen, J Peter, additional, Platonov, Pyotr G, additional, Duru, Firat, additional, Haugaa, Kristina H, additional, Khairy, Paul, additional, Hauer, Richard N W, additional, Calkins, Hugh, additional, te Riele, Anneline S J M, additional, and James, Cynthia A, additional

Published
2022
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28. Comparing Non-invasive Inverse Electrocardiography With Invasive Endocardial and Epicardial Electroanatomical Mapping During Sinus Rhythm

Author

Roudijk, Robert W., primary, Boonstra, Machteld J., additional, Brummel, Rolf, additional, Kassenberg, Wil, additional, Blom, Lennart J., additional, Oostendorp, Thom F., additional, te Riele, Anneline S. J. M., additional, van der Heijden, Jeroen F., additional, Asselbergs, Folkert W., additional, van Dam, Peter M., additional, and Loh, Peter, additional

Published
2021
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29. Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy

Author

Bosman, Laurens P, primary, Nielsen Gerlach, Claire L, additional, Cadrin-Tourigny, Julia, additional, Orgeron, Gabriela, additional, Tichnell, Crystal, additional, Murray, Brittney, additional, Bourfiss, Mimount, additional, van der Heijden, Jeroen F, additional, Yap, Sing-Chien, additional, Zeppenfeld, Katja, additional, van den Berg, Maarten P, additional, Wilde, Arthur A M, additional, Asselbergs, Folkert W, additional, Tandri, Hariskrishna, additional, Calkins, Hugh, additional, van Tintelen, J Peter, additional, James, Cynthia A, additional, and te Riele, Anneline S J M, additional

Published
2021
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30. Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers

Author

Bhonsale, Aditya, Groeneweg, Judith A., James, Cynthia A., Dooijes, Dennis, Tichnell, Crystal, Jongbloed, Jan D. H., Murray, Brittney, te Riele, Anneline S. J. M., van den Berg, Maarten P., Bikker, Hennie, Atsma, Douwe E., de Groot, Natasja M., Houweling, Arjan C., van der Heijden, Jeroen F., Russell, Stuart D., Doevendans, Pieter A., van Veen, Toon A., Tandri, Harikrishna, Wilde, Arthur A., Judge, Daniel P., van Tintelen, J. Peter, Calkins, Hugh, and Hauer, Richard N.

Published
2015
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31. Comparing Non-invasive Inverse Electrocardiography With Invasive Endocardial and Epicardial Electroanatomical Mapping During Sinus Rhythm

Author

Electrofysiologie, Afdeling Hartcatheterisatie, Team Onderzoek, Arts Assistenten Cardiologie, Circulatory Health, Team Medisch, Roudijk, Robert W, Boonstra, Machteld J, Brummel, Rolf, Kassenberg, Wil, Blom, Lennart J, Oostendorp, Thom F, Te Riele, Anneline S J M, van der Heijden, Jeroen F, Asselbergs, Folkert W, van Dam, Peter M, Loh, Peter, Electrofysiologie, Afdeling Hartcatheterisatie, Team Onderzoek, Arts Assistenten Cardiologie, Circulatory Health, Team Medisch, Roudijk, Robert W, Boonstra, Machteld J, Brummel, Rolf, Kassenberg, Wil, Blom, Lennart J, Oostendorp, Thom F, Te Riele, Anneline S J M, van der Heijden, Jeroen F, Asselbergs, Folkert W, van Dam, Peter M, and Loh, Peter

Published
2021

32. Improving Diagnostic Value of Echocardiography in Arrhythmogenic Right Ventricular Cardiomyopathy Using Deformation Imaging

Author

Team Onderzoek, Arts Assistenten Cardiologie, Team Medisch, Circulatory Health, Kirkels, Feddo P, Bosman, Laurens P, Taha, Karim, Cramer, Maarten J, van der Heijden, Jeroen F, Hauer, Richard N W, Asselbergs, Folkert W, Te Riele, Anneline S J M, Teske, Arco J, Team Onderzoek, Arts Assistenten Cardiologie, Team Medisch, Circulatory Health, Kirkels, Feddo P, Bosman, Laurens P, Taha, Karim, Cramer, Maarten J, van der Heijden, Jeroen F, Hauer, Richard N W, Asselbergs, Folkert W, Te Riele, Anneline S J M, and Teske, Arco J

Published
2021

33. Discovering and Visualizing Disease-specific Electrocardiogram Features Using Deep Learning: Proof-of-concept in Phospholamban Gene Mutation Carriers

Author

Team Onderzoek, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, van de Leur, Rutger, Taha, Karim, Bos, Max N, van der Heijden, Jeroen F, Gupta, Deepak, Cramer, Maarten J, Hassink, Rutger J, van der Harst, Pim, Doevendans, Pieter A, Asselbergs, Folkert W, van Es, René, Team Onderzoek, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, van de Leur, Rutger, Taha, Karim, Bos, Max N, van der Heijden, Jeroen F, Gupta, Deepak, Cramer, Maarten J, Hassink, Rutger J, van der Harst, Pim, Doevendans, Pieter A, Asselbergs, Folkert W, and van Es, René

Published
2021

34. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration

Author

Team Onderzoek, Onderzoek Precision medicine, Team Medisch, Circulatory Health, Genetica, Cancer, Arts Assistenten Cardiologie, Cadrin-Tourigny, Julia, Bosman, Laurens P, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Lie, Øyvind H, Saguner, Ardan M, Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P, Asselbergs, Folkert W, Wilde, Arthur A M, Krahn, Andrew D, Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L, Kamel, Ihab R, Crosson, Jane E, Judge, Daniel P, Yap, Sing-Chien, Van der Heijden, Jeroen F, Tandri, Harikrishna, Jongbloed, Jan D H, van Tintelen, J Peter, Platonov, Pyotr G, Duru, Firat, Haugaa, Kristina H, Khairy, Paul, Hauer, Richard N W, Calkins, Hugh, Te Riele, Anneline S J M, James, Cynthia A, Team Onderzoek, Onderzoek Precision medicine, Team Medisch, Circulatory Health, Genetica, Cancer, Arts Assistenten Cardiologie, Cadrin-Tourigny, Julia, Bosman, Laurens P, Wang, Weijia, Tadros, Rafik, Bhonsale, Aditya, Bourfiss, Mimount, Lie, Øyvind H, Saguner, Ardan M, Svensson, Anneli, Andorin, Antoine, Tichnell, Crystal, Murray, Brittney, Zeppenfeld, Katja, van den Berg, Maarten P, Asselbergs, Folkert W, Wilde, Arthur A M, Krahn, Andrew D, Talajic, Mario, Rivard, Lena, Chelko, Stephen, Zimmerman, Stefan L, Kamel, Ihab R, Crosson, Jane E, Judge, Daniel P, Yap, Sing-Chien, Van der Heijden, Jeroen F, Tandri, Harikrishna, Jongbloed, Jan D H, van Tintelen, J Peter, Platonov, Pyotr G, Duru, Firat, Haugaa, Kristina H, Khairy, Paul, Hauer, Richard N W, Calkins, Hugh, Te Riele, Anneline S J M, and James, Cynthia A

Published
2021

36. A head-to-head comparison of speckle tracking echocardiography and feature tracking cardiovascular magnetic resonance imaging in right ventricular deformation

Author

Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Circulatory Health, Team Medisch, Researchgr. Hart-brein as., Brain, Taha, Karim, Bourfiss, Mimount, Te Riele, Anneline S.J.M., Cramer, Maarten Jan M., Van Der Heijden, Jeroen F., Asselbergs, Folkert W., Velthuis, Birgitta K., Teske, Arco J., Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Circulatory Health, Team Medisch, Researchgr. Hart-brein as., Brain, Taha, Karim, Bourfiss, Mimount, Te Riele, Anneline S.J.M., Cramer, Maarten Jan M., Van Der Heijden, Jeroen F., Asselbergs, Folkert W., Velthuis, Birgitta K., and Teske, Arco J.

Published
2021

37. Mutation-Positive Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: The Triangle of Dysplasia Displaced

Author

TE RIELE, ANNELINE S.J.M., JAMES, CYNTHIA A., PHILIPS, BINU, RASTEGAR, NEDA, BHONSALE, ADITYA, GROENEWEG, JUDITH A., MURRAY, BRITTNEY, TICHNELL, CRYSTAL, JUDGE, DANIEL P., VAN DER HEIJDEN, JEROEN F., CRAMER, MAARTEN J.M., VELTHUIS, BIRGITTA K., BLUEMKE, DAVID A., ZIMMERMAN, STEFAN L., KAMEL, IHAB R., HAUER, RICHARD N.W., CALKINS, HUGH, and TANDRI, HARIKRISHNA

Published
2013
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39. Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy : From Disease towards Asymptomatic Carriers of Pathogenic Variants

Author

Roudijk, Rob W, Bosman, Laurens P, van der Heijden, Jeroen F, de Bakker, Jacques M T, Hauer, Richard N W, van Tintelen, J Peter, Asselbergs, Folkert W, Te Riele, Anneline S J M, Loh, KP, Roudijk, Rob W, Bosman, Laurens P, van der Heijden, Jeroen F, de Bakker, Jacques M T, Hauer, Richard N W, van Tintelen, J Peter, Asselbergs, Folkert W, Te Riele, Anneline S J M, and Loh, KP

Published
2020

40. Quantitative approach to fragmented QRS in arrhythmogenic cardiomyopathy: From disease towards asymptomatic carriers of pathogenic variants

Author

Cardiologie zorg, Electrofysiologie, Team Onderzoek, Team Medisch, Circulatory Health, Medische Fysiologie, Genetica, Genetica Groep Van Tintelen, Cancer, Roudijk, Rob W., Bosman, Laurens P., van der Heijden, Jeroen F., de Bakker, Jacques M.T., Hauer, Richard N.W., van Tintelen, J. Peter, Asselbergs, Folkert W., Te Riele, Anneline S.J.M., Loh, Peter, Cardiologie zorg, Electrofysiologie, Team Onderzoek, Team Medisch, Circulatory Health, Medische Fysiologie, Genetica, Genetica Groep Van Tintelen, Cancer, Roudijk, Rob W., Bosman, Laurens P., van der Heijden, Jeroen F., de Bakker, Jacques M.T., Hauer, Richard N.W., van Tintelen, J. Peter, Asselbergs, Folkert W., Te Riele, Anneline S.J.M., and Loh, Peter

Published
2020

41. Evaluation of Disease Progression in Arrhythmogenic Cardiomyopathy: The Change of Echocardiographic Deformation Characteristics Over Time

Author

Team Onderzoek, Onderzoek Device, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Taha, Karim, Mast, Thomas P, Cramer, Maarten J, van der Heijden, Jeroen F, Asselbergs, Folkert W, Doevendans, Pieter A, Teske, Arco J, Team Onderzoek, Onderzoek Device, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Taha, Karim, Mast, Thomas P, Cramer, Maarten J, van der Heijden, Jeroen F, Asselbergs, Folkert W, Doevendans, Pieter A, and Teske, Arco J

Published
2020

42. Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation

Author

Team Onderzoek, Onderzoek Precision medicine, Electrofysiologie, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Genetica, Cancer, Arts Assistenten Cardiologie, Bosman, Laurens P, Cadrin-Tourigny, Julia, Bourfiss, Mimount, Aliyari Ghasabeh, Mounes, Sharma, Apurva, Tichnell, Crystal, Roudijk, Rob W, Murray, Brittney, Tandri, Harikrishna, Khairy, Paul, Kamel, Ihab R, Zimmerman, Stefan L, Reitsma, Johannes B, Asselbergs, Folkert W, van Tintelen, J Peter, van der Heijden, Jeroen F, Hauer, Richard N W, Calkins, Hugh, James, Cynthia A, Te Riele, Anneline S J M, Team Onderzoek, Onderzoek Precision medicine, Electrofysiologie, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Genetica, Cancer, Arts Assistenten Cardiologie, Bosman, Laurens P, Cadrin-Tourigny, Julia, Bourfiss, Mimount, Aliyari Ghasabeh, Mounes, Sharma, Apurva, Tichnell, Crystal, Roudijk, Rob W, Murray, Brittney, Tandri, Harikrishna, Khairy, Paul, Kamel, Ihab R, Zimmerman, Stefan L, Reitsma, Johannes B, Asselbergs, Folkert W, van Tintelen, J Peter, van der Heijden, Jeroen F, Hauer, Richard N W, Calkins, Hugh, James, Cynthia A, and Te Riele, Anneline S J M

Published
2020

43. Automatic Triage of 12-Lead ECGs Using Deep Convolutional Neural Networks

Author

Team Onderzoek, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, van de Leur, Rutger R, Blom, Lennart J, Gavves, Efstratios, Hof, Irene E, van der Heijden, Jeroen F, Clappers, Nick C, Doevendans, Pieter A, Hassink, Rutger J, van Es, René, Team Onderzoek, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, van de Leur, Rutger R, Blom, Lennart J, Gavves, Efstratios, Hof, Irene E, van der Heijden, Jeroen F, Clappers, Nick C, Doevendans, Pieter A, Hassink, Rutger J, and van Es, René

Published
2020

45. Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy.

Author

Bosman, Laurens P, Gerlach, Claire L Nielsen, Cadrin-Tourigny, Julia, Orgeron, Gabriela, Tichnell, Crystal, Murray, Brittney, Bourfiss, Mimount, Heijden, Jeroen F van der, Yap, Sing-Chien, Zeppenfeld, Katja, Berg, Maarten P van den, Wilde, Arthur A M, Asselbergs, Folkert W, Tandri, Hariskrishna, Calkins, Hugh, Tintelen, J Peter van, James, Cynthia A, Riele, Anneline S J M te, Nielsen Gerlach, Claire L, and van der Heijden, Jeroen F

Subjects
CONSENSUS (Social sciences), IMPLANTABLE cardioverter-defibrillators, ARRHYTHMOGENIC right ventricular dysplasia, CARDIAC arrest, RESEARCH funding, ARRHYTHMIA, DISEASE complications
Abstract

Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have an increased risk of ventricular arrhythmias (VA). Four implantable cardioverter-defibrillator (ICD) recommendation algorithms are available The International Task Force Consensus ('ITFC'), an ITFC modification by Orgeron et al. ('mITFC'), the AHA/HRS/ACC guideline for VA management ('AHA'), and the HRS expert consensus statement ('HRS'). This study aims to validate and compare the performance of these algorithms in ARVC.Methods and Results: We classified 617 definite ARVC patients (38.5 ± 15.1 years, 52.4% male, 39.2% prior sustained VA) according to four algorithms. Clinical performance was evaluated by sensitivity, specificity, ROC-analysis, and decision curve analysis for any sustained VA and for fast VA (>250 b.p.m.). During 6.4 [2.8-11.5] years follow-up, 282 (45.7%) patients experienced any sustained VA, and 63 (10.2%) fast VA. For any sustained VA, ITFC and mITFC provide higher sensitivity than AHA and HRS (94.0-97.8% vs. 76.7-83.5%), but lower specificity (15.9-32.0% vs. 42.7%-60.1%). Similarly, for fast VA, ITFC and mITFC provide higher sensitivity than AHA and HRS (95.2-97.1% vs. 76.7-78.4%) but lower specificity (42.7-43.1 vs. 76.7-78.4%). Decision curve analysis showed ITFC and mITFC to be superior for a 5-year sustained VA risk ICD indication threshold between 5-25% or 2-9% for fast VA.Conclusion: The ITFC and mITFC provide the highest protection rates, whereas AHA and HRS decrease unnecessary ICD placements. ITFC or mITFC should be used if we consider the 5-year threshold for ICD indication to lie within 5-25% for sustained VA or 2-9% for fast VA. These data will inform decision-making for ICD placement in ARVC. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Diagnosing arrhythmogenic right ventricular cardiomyopathy by 2010 Task Force Criteria: clinical performance and simplified practical implementation

Author

Bosman, Laurens P, primary, Cadrin-Tourigny, Julia, primary, Bourfiss, Mimount, primary, Aliyari Ghasabeh, Mounes, primary, Sharma, Apurva, primary, Tichnell, Crystal, primary, Roudijk, Rob W, primary, Murray, Brittney, primary, Tandri, Harikrishna, primary, Khairy, Paul, primary, Kamel, Ihab R, primary, Zimmerman, Stefan L, primary, Reitsma, Johannes B, primary, Asselbergs, Folkert W, primary, van Tintelen, J Peter, primary, van der Heijden, Jeroen F, primary, Hauer, Richard N W, primary, Calkins, Hugh, primary, James, Cynthia A, primary, and te Riele, Anneline S J M, primary

Published
2020
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50. Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy: From Disease towards Asymptomatic Carriers of Pathogenic Variants

Author

Roudijk, Rob W., primary, Bosman, Laurens P., additional, van der Heijden, Jeroen F., additional, de Bakker, Jacques M. T., additional, Hauer, Richard N. W., additional, van Tintelen, J. Peter, additional, Asselbergs, Folkert W., additional, te Riele, Anneline S. J. M., additional, and Loh, Peter, additional

Published
2020
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