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2. Effect of Binocular Disparity on Learning Anatomy with Stereoscopic Augmented Reality Visualization: A Double Center Randomized Controlled Trial

Author

Bogomolova, Katerina, Vorstenbosch, Marc A. T. M., El Messaoudi, Inssaf, Holla, Micha, Hovius, Steven E. R., van der Hage, Jos A., and Hierck, Beerend P.

Abstract

Binocular disparity provides one of the important depth cues within stereoscopic three-dimensional (3D) visualization technology. However, there is limited research on its effect on learning within a 3D augmented reality (AR) environment. This study evaluated the effect of binocular disparity on the acquisition of anatomical knowledge and perceived cognitive load in relation to visual-spatial abilities. In a double-center randomized controlled trial, first-year (bio)medical undergraduates studied lower extremity anatomy in an interactive 3D AR environment either with a stereoscopic 3D view (n = 32) or monoscopic 3D view (n = 34). Visual-spatial abilities were tested with a mental rotation test. Anatomical knowledge was assessed by a validated 30-item written test and 30-item specimen test. Cognitive load was measured by the NASA-TLX questionnaire. Students in the stereoscopic 3D and monoscopic 3D groups performed equally well in terms of percentage correct answers (written test: 47.9 ± 15.8 vs. 49.1 ± 18.3; P = 0.635; specimen test: 43.0 ± 17.9 vs. 46.3 ± 15.1; P = 0.429), and perceived cognitive load scores (6.2 ± 1.0 vs. 6.2 ± 1.3; P = 0.992). Regardless of intervention, visual-spatial abilities were positively associated with the specimen test scores ([eta squared] = 0.13, P = 0.003), perceived representativeness of the anatomy test questions (P = 0.010) and subjective improvement in anatomy knowledge (P < 0.001). In conclusion, binocular disparity does not improve learning anatomy. Motion parallax should be considered as another important depth cue that contributes to depth perception during learning in a stereoscopic 3D AR environment.

Published
2023
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5. Local treatment in metastatic GIST patients: A multicentre analysis from the Dutch GIST Registry

Author

Brink, Pien, Kalisvaart, Gijsbert M., Schrage, Yvonne M., Mohammadi, Mahmoud, Ijzerman, Nikki S., Bleckman, Roos F., Wal, Tom, de Geus-Oei, Lioe-Fee, Hartgrink, Henk H., Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Oosten, Astrid W., Been, Lukas B., van Ginkel, Robert J., Reyners, An K.L., Bonenkamp, Han J., Desar, Ingrid M.E., Gelderblom, Hans, van Houdt, Winan J., Steeghs, Neeltje, Fiocco, Marta, and van der Hage, Jos A.

Published
2023
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8. Breast Cancer

Author

Valdés Olmos, Renato A., Pereira Arias-Bouda, Lenka M., Rietbergen, Daphne D. D., van der Hage, Jos A., Collarino, Angela, editor, Vidal-Sicart, Sergi, editor, and Valdés Olmos, Renato A., editor

Published
2022
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9. Survival after Resection of Malignant Peripheral Nerve Sheath Tumors: introducing and validating a novel type-specific prognostic model

Author

Acem, Ibtissam, primary, Steyerberg, Ewout W, additional, Spreafico, Marta, additional, Grünhagen, Dirk J, additional, Callegaro, Dario, additional, Spinner, Robert J, additional, Pendleton, Courtney, additional, Coert, J Henk, additional, Miceli, Rosalba, additional, Abruzzese, Giulia, additional, Flucke, Uta E, additional, Slooff, Willem-Bart M, additional, van Dalen, Thijs, additional, Been, Lukas B, additional, Bonenkamp, Han J, additional, Anten, Monique H M E, additional, Broen, Martinus P G, additional, Bemelmans, Marc H A, additional, Bramer, Jos A M, additional, Schaap, Gerard R, additional, Kievit, Arthur J, additional, van der Hage, Jos, additional, van Houdt, Winan J, additional, van de Sande, Michiel A J, additional, Gronchi, Alessandro, additional, Verhoef, Cornelis, additional, and Martin, Enrico, additional

Published
2024
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10. Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Author

Reijers, Irene L. M., Menzies, Alexander M., van Akkooi, Alexander C. J., Versluis, Judith M., van den Heuvel, Noëlle M. J., Saw, Robyn P. M., Pennington, Thomas E., Kapiteijn, Ellen, van der Veldt, Astrid A. M., Suijkerbuijk, Karijn P. M., Hospers, Geke A. P., Rozeman, Elisa A., Klop, Willem M. C., van Houdt, Winan J., Sikorska, Karolina, van der Hage, Jos A., Grünhagen, Dirk J., Wouters, Michel W., Witkamp, Arjen J., Zuur, Charlotte L., Lijnsvelt, Judith M., Torres Acosta, Alejandro, Grijpink-Ongering, Lindsay G., Gonzalez, Maria, Jóźwiak, Katarzyna, Bierman, Carolien, Shannon, Kerwin F., Ch’ng, Sydney, Colebatch, Andrew J., Spillane, Andrew J., Haanen, John B. A. G., Rawson, Robert V., van de Wiel, Bart A., van de Poll-Franse, Lonneke V., Scolyer, Richard A., Boekhout, Annelies H., Long, Georgina V., and Blank, Christian U.

Published
2022
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11. Health-related Quality of Life of Patients With Non–Intra-abdominal Desmoid-Type Fibromatosis During Active Surveillance: Results of a Prospective Observational Study

Author

Schut, Anne-Rose W., Timbergen, Milea J.M., Nasserinejad, Kazem, van Dalen, Thijs, van Houdt, Winan J., Bonenkamp, Johannes J., Sleijfer, Stefan, Grünhagen, Dirk J., Verhoef, Cornelis, Husson, Olga, Schut, Anne-Rose W., Timbergen, Milea J.M., van Broekhoven, Danique L.M., Sleijfer, Stefan, Grünhagen, Dirk J., Verhoef, Cornelis, van Houdt, Winan J., van Coevorden, Frits, van Dalen, Thijs, van der Hage, Jos. A., Dijkstra, Sander D.S., Bonenkamp, Johannes J., Been, Lukas B., van Ginkel, Robert J., and Bemelmans, Marc H.A.

Published
2023
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13. Anatomy Dissection Course Improves the Initially Lower Levels of Visual-Spatial Abilities of Medical Undergraduates

Author

Bogomolova, Katerina, Hierck, Beerend P., van der Hage, Jos A., and Hovius, Steven E. R.

Abstract

Visual-spatial abilities are considered a successful predictor in anatomy learning. Previous research suggest that visual-spatial abilities can be trained, and the magnitude of improvement can be affected by initial levels of spatial skills. This case-control study aimed to evaluate (1) the impact of an extra-curricular anatomy dissection course on visual-spatial abilities of medical undergraduates and (2) the magnitude of improvement in students with initially lower levels of visual-spatial abilities, and (3) whether the choice for the course was related to visual-spatial abilities. Course participants (n = 45) and controls (n = 65) were first and second-year medical undergraduates who performed a Mental Rotations Test (MRT) before and 10 weeks after the course. At baseline, there was no significant difference in MRT scores between course participants and controls. At the end of the course, participants achieved a greater improvement than controls (first-year: [Delta]6.0 ± 4.1 vs. [Delta]4.9 ± 3.2; ANCOVA, "P" = 0.019, Cohen's "d" = 0.41; second-year: [Delta]6.5 ± 3.3 vs. [Delta]6.1 ± 4.0; "P" = 0.03, Cohen's "d" = 0.11). Individuals with initially lower scores on the MRT pretest showed the largest improvement ([Delta]8.4 ± 2.3 vs. [Delta]6.8 ± 2.8; "P" = 0.011, Cohen's "d" = 0.61). In summary, (1) an anatomy dissection course improved visual-spatial abilities of medical undergraduates; (2) a substantial improvement was observed in individuals with initially lower scores on the visual-spatial abilities test indicating a different trajectory of improvement; (3) students' preferences for attending extracurricular anatomy dissection course was not driven by visual-spatial abilities.

Published
2020
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14. The Effect of Stereoscopic Augmented Reality Visualization on Learning Anatomy and the Modifying Effect of Visual-Spatial Abilities: A Double-Center Randomized Controlled Trial

Author

Bogomolova, Katerina, van der Ham, Ineke J. M., Dankbaar, Mary E. W., van den Broek, Walter W., Hovius, Steven E. R., van der Hage, Jos A., and Hierck, Beerend P.

Abstract

Monoscopically projected three-dimensional (3D) visualization technology may have significant disadvantages for students with lower visual-spatial abilities despite its overall effectiveness in teaching anatomy. Previous research suggests that stereopsis may facilitate a better comprehension of anatomical knowledge. This study evaluated the educational effectiveness of stereoscopic augmented reality (AR) visualization and the modifying effect of visual-spatial abilities on learning. In a double-center randomized controlled trial, first- and second-year (bio)medical undergraduates studied lower limb anatomy with stereoscopic 3D AR model (n = 20), monoscopic 3D desktop model (n = 20), or two-dimensional (2D) anatomical atlas (n = 18). Visual-spatial abilities were tested with Mental Rotation Test (MRT), Paper Folding Test (PFT), and Mechanical Reasoning (MR) Test. Anatomical knowledge was assessed by the validated 30-item paper posttest. The overall posttest scores in the stereoscopic 3D AR group (47.8%) were similar to those in the monoscopic 3D desktop group (38.5%; P = 0.240) and the 2D anatomical atlas group (50.9%; P = 1.00). When stratified by visual-spatial abilities test scores, students with lower MRT scores achieved higher posttest scores in the stereoscopic 3D AR group (49.2%) as compared to the monoscopic 3D desktop group (33.4%; P = 0.015) and similar to the scores in the 2D group (46.4%; P = 0.99). Participants with higher MRT scores performed equally well in all conditions. It is instrumental to consider an aptitude-treatment interaction caused by visual-spatial abilities when designing research into 3D learning. Further research is needed to identify contributing features and the most effective way of introducing this technology into current educational programs.

Published
2020
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16. De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1–2 N0 breast cancer treated with mastectomy: nationwide registry study (BOOG 2013-07)

Author

de Wild, Sabine R, primary, van Roozendaal, Lori M, additional, de Wilt, Johannes H W, additional, van Dalen, Thijs, additional, van der Hage, Jos A, additional, van Duijnhoven, Frederieke H, additional, Simons, Janine M, additional, Schipper, Robert-Jan, additional, de Munck, Linda, additional, van Kuijk, Sander M J, additional, Boersma, Liesbeth J, additional, Linn, Sabine C, additional, Lobbes, Marc B I, additional, Poortmans, Philip M P, additional, Tjan-Heijnen, Vivianne C G, additional, van de Vijver, Koen K B T, additional, de Vries, Jolanda, additional, Westenberg, A Helen, additional, Strobbe, Luc J A, additional, and Smidt, Marjolein L, additional

Published
2024
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17. The ESSO core curriculum committee update on surgical oncology

Author

van der Hage, Jos, Sandrucci, Sergio, Audisio, Riccardo, Wyld, Lynda, Søreide, Kjetil, Amaral, Teresa, Bahadoer, Viren, Beets, Geerard, Benstead, Kim, Berge Nilsen, Elisabeth, Bol, Kalijn, Brandl, Andreas, Braun, Jerry, Cufer, Tanja, Dopazo, Cristina, Edhemovic, Ibrahim, Eriksen, Jesper Grau, Fiore, Marco, van Ginhoven, Tessa, Gonzalez-Moreno, Santiago, Hutteman, Merlijn, Masannat, Yazan, Onesti, Elisa Concetta, Rau, Beate, De Reijke, Theo, Rubio, Isabel, Ruurda, Jelle, Soreide, Kjetil, Stattner, Stefan, Trapani, Dario, D'Ugo, Domenico, Vriens, Menno, and Zahl Eriksson, Ane Gerda

Published
2021
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19. Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group

Author

Bagaria, Sanjay P., Swallow, Carol, Suraweera, Harini, Raut, Chandrajit P., Fairweather, Mark, Cananzi, Ferdinando, Quagliuolo, Vittorio, Grignani, Giovanni, Hompes, Daphne, Ford, Samuel J., Nessim, Carolyn, Apte, Sameer, Skoczylas, Jacek, Rutkowski, Piotr, Bonvalot, Sylvie, Tzanis, Dimitri, Gabriel, Emmanuel, Pennacchioli, Elisabetta, Albertsmeier, Markus, Canter, Robert J., Pollock, Raphael, Grignol, Valerie, Cardona, Kenneth, Gamboa, Adriana C., Novak, Marko, Stoeckle, Eberhard, Almquist, Martin, Ahuja, Nita, Klemen, Nicholas, Van Houdt, Winan, Gyorki, David, Gangi, Alexandra, Rastrelli, Marco, van der Hage, Jos, Schrage, Yvonne, Valeri, Sergio, Conti, Lorenzo, Spiegel, Matthew R., Li, Zhou, Fiore, Marco, and Gronchi, Alessandro

Published
2021
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23. Survival after resection of malignant peripheral nerve sheath tumors: Introducing and validating a novel type-specific prognostic model

Author

Zorgeenheid Plastische Chirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Neurochirurgen, Acem, Ibtissam, Steyerberg, Ewout W, Spreafico, Marta, Grünhagen, Dirk J, Callegaro, Dario, Spinner, Robert J, Pendleton, Courtney, Coert, J Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E, Slooff, Willem-Bart M, van Dalen, Thijs, Been, Lukas B, Bonenkamp, Han J, Anten, Monique H M E, Broen, Martinus P G, Bemelmans, Marc H A, Bramer, Jos A M, Schaap, Gerard R, Kievit, Arthur J, van der Hage, Jos, van Houdt, Winan J, van de Sande, Michiel A J, Gronchi, Alessandro, Verhoef, Cornelis, Martin, Enrico, Zorgeenheid Plastische Chirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Neurochirurgen, Acem, Ibtissam, Steyerberg, Ewout W, Spreafico, Marta, Grünhagen, Dirk J, Callegaro, Dario, Spinner, Robert J, Pendleton, Courtney, Coert, J Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E, Slooff, Willem-Bart M, van Dalen, Thijs, Been, Lukas B, Bonenkamp, Han J, Anten, Monique H M E, Broen, Martinus P G, Bemelmans, Marc H A, Bramer, Jos A M, Schaap, Gerard R, Kievit, Arthur J, van der Hage, Jos, van Houdt, Winan J, van de Sande, Michiel A J, Gronchi, Alessandro, Verhoef, Cornelis, and Martin, Enrico

Published
2024

24. Survival after resection of malignant peripheral nerve sheath tumors:Introducing and validating a novel type-specific prognostic model

Author

Acem, Ibtissam, Steyerberg, Ewout W., Spreafico, Marta, Gruenhagen, Dirk J., Callegaro, Dario, Spinner, Robert J., Pendleton, Courtney, Coert, J. Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E., Slooff, Willem-Bart M., van Dalen, Thijs, Been, Lukas B., Bonenkamp, Han J., Anten, Monique H. M. E., Broen, Martinus P. G., Bemelmans, Marc H. A., Bramer, Jos A. M., Schaap, Gerard R., Kievit, Arthur J., van der Hage, Jos, van Houdt, Winan J., van de Sande, Michiel A. J., Gronchi, Alessandro, Verhoef, Cornelis, Martin, Enrico, Acem, Ibtissam, Steyerberg, Ewout W., Spreafico, Marta, Gruenhagen, Dirk J., Callegaro, Dario, Spinner, Robert J., Pendleton, Courtney, Coert, J. Henk, Miceli, Rosalba, Abruzzese, Giulia, Flucke, Uta E., Slooff, Willem-Bart M., van Dalen, Thijs, Been, Lukas B., Bonenkamp, Han J., Anten, Monique H. M. E., Broen, Martinus P. G., Bemelmans, Marc H. A., Bramer, Jos A. M., Schaap, Gerard R., Kievit, Arthur J., van der Hage, Jos, van Houdt, Winan J., van de Sande, Michiel A. J., Gronchi, Alessandro, Verhoef, Cornelis, and Martin, Enrico

Abstract

Background: This study aimed to assess the performance of currently available risk calculators in a cohort of patients with malignant peripheral nerve sheath tumors (MPNST) and to create an MPNST-specific prognostic model including type-specific predictors for overall survival (OS). Methods: This is a retrospective multicenter cohort study of patients with MPNST from 11 secondary or tertiary centers in The Netherlands, Italy and the United States of America. All patients diagnosed with primary MPNST who underwent macroscopically complete surgical resection from 2000 to 2019 were included in this study. A multivariable Cox proportional hazard model for OS was estimated with prespecified predictors (age, grade, size, NF-1 status, triton status, depth, tumor location, and surgical margin). Model performance was assessed for the Sarculator and PERSARC calculators by examining discrimination (C-index) and calibration (calibration plots and observed-expected statistic; O/E-statistic). Internal-external cross-validation by different regions was performed to evaluate the generalizability of the model. Results: A total of 507 patients with primary MPNSTs were included from 11 centers in 7 regions. During follow-up (median 8.7 years), 211 patients died. The C-index was 0.60 (95% CI 0.53-0.67) for both Sarculator and PERSARC. The MPNST-specific model had a pooled C-index of 0.69 (95%CI 0.65-0.73) at validation, with adequate discrimination and calibration across regions. Conclusions: The MPNST-specific MONACO model can be used to predict 3-, 5-, and 10-year OS in patients with primary MPNST who underwent macroscopically complete surgical resection. Further validation may refine the model to inform patients and physicians on prognosis and support them in shared decision-making.

Published
2024

25. De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1-2 N0 breast cancer treated with mastectomy:nationwide registry study (BOOG 2013-07)

Author

de Wild, Sabine R., van Roozendaal, Lori M., de Wilt, Johannes H.W., van Dalen, Thijs, van der Hage, Jos A., van Duijnhoven, Frederieke H., Simons, Janine M., Schipper, Robert Jan, de Munck, Linda, van Kuijk, Sander M.J., Boersma, Liesbeth J., Linn, Sabine C., Lobbes, Marc B.I., Poortmans, Philip M.P., Tjan-Heijnen, Vivianne C.G., van de Vijver, Koen K.B.T., de Vries, Jolanda, Westenberg, A. Helen, Strobbe, Luc J.A., Smidt, Marjolein L., de Wild, Sabine R., van Roozendaal, Lori M., de Wilt, Johannes H.W., van Dalen, Thijs, van der Hage, Jos A., van Duijnhoven, Frederieke H., Simons, Janine M., Schipper, Robert Jan, de Munck, Linda, van Kuijk, Sander M.J., Boersma, Liesbeth J., Linn, Sabine C., Lobbes, Marc B.I., Poortmans, Philip M.P., Tjan-Heijnen, Vivianne C.G., van de Vijver, Koen K.B.T., de Vries, Jolanda, Westenberg, A. Helen, Strobbe, Luc J.A., and Smidt, Marjolein L.

Abstract

Background: Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1-2 N0 breast cancer operated with breast-conserving surgery who have limited metastatic burden in the sentinel lymph node. The aim of this registry study was to provide insight into the oncological safety of omitting completion axillary treatment in patients operated with mastectomy who have limited-volume sentinel lymph node metastasis. Methods: Women diagnosed in 2013-2014 with unilateral cT1-2 N0 breast cancer treated with mastectomy, with one to three sentinel lymph node metastases (pN1mi-pN1a), were identified from the Netherlands Cancer Registry, and classified by axillary treatment: no completion axillary treatment, completion axillary lymph node dissection, regional radiotherapy, or completion axillary lymph node dissection followed by regional radiotherapy. The primary endpoint was 5-year regional recurrence rate. Secondary endpoints included recurrence-free interval and overall survival, among others. Results: In total, 1090 patients were included (no completion axillary treatment, 219 (20.1%); completion axillary lymph node dissection, 437 (40.1%); regional radiotherapy, 327 (30.0%); completion axillary lymph node dissection and regional radiotherapy, 107 (9.8%)). Patients in the group without completion axillary treatment had more favourable tumour characteristics and were older. The overall 5-year regional recurrence rate was 1.3%, and did not differ significantly between the groups. The recurrence-free interval was also comparable among groups. The group of patients who did not undergo completion axillary treatment had statistically significantly worse 5-year overall survival, owing to a higher percentage of non-cancer deaths. Conclusion:In this registry study of patients with cT1-2 N0 breast cancer treated with mastectomy, with low-volume sentinel lymph

Published
2024

26. Quality of treatment and surgical approach for rectal gastrointestinal stromal tumour (GIST) in a large European cohort

Author

IJzerman, Nikki S., Mohammadi, Mahmoud, Tzanis, Dimitri, Gelderblom, Hans, Fiore, Marco, Fumagalli, Elena, Rutkowski, Piotr, Bylina, Elzbieta, Zavrakidis, Ioannis, Steeghs, Neeltje, Bonenkamp, Han J., van Etten, Boudewijn, Grünhagen, Dirk J., Rasheed, Shahnawaz, Tekkis, Paris, Honoré, Charles, van Houdt, Winan, van der Hage, Jos, Bonvalot, Sylvie, Schrage, Yvonne, and Smith, Myles

Published
2020
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28. Correction: Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group

Author

Bagaria, Sanjay P., Swallow, Carol, Suraweera, Harini, Raut, Chandrajit P., Fairweather, Mark, Cananzi, Ferdinando, Quagliuolo, Vittorio, Grignani, Giovanni, Hompes, Daphne, Ford, Samuel J., Nessim, Carolyn, Apte, Sameer, Skoczylas, Jacek, Rutkowski, Piotr, Bonvalot, Sylvie, Tzanis, Dimitri, Gabriel, Emmanuel, Pennacchioli, Elisabetta, Albertsmeier, Markus, Canter, Robert J., Pollock, Raphael, Grignol, Valerie, Cardona, Kenneth, Gamboa, Adriana C., Novak, Marko, Stoeckle, Eberhard, Almquist, Martin, Ahuja, Nita, Klemen, Nicholas, Van Houdt, Winan, Gyorki, David, Gangi, Alexandra, Rastrelli, Marco, van der Hage, Jos, Schrage, Yvonne, Valeri, Sergio, Conti, Lorenzo, Spiegel, Matthew R., Li, Zhou, Fiore, Marco, and Gronchi, Alessandro

Published
2022
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31. Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma

Author

Jeys, Lee M., Laitinen, Minna K., Pollock, Rob, Aston, Will, van der Hage, Jos A., Dijkstra, PD Sander, Ferguson, Peter C., Griffin, Anthony M., Willeumier, Julie J., Wunder, Jay S., Styring, Emelie, Posch, Florian, Zaikova, Olga, Maretty-Kongstad, Katja, Keller, Johnny, Leithner, Andreas, Smolle, Maria A., Haas, Rick L., Rueten-Budde, A.J., van Praag, V.M., van de Sande, M.A.J., and Fiocco, M.

Published
2018
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36. De-escalation of axillary treatment in case of a positive sentinel lymph node biopsy in cT1-2N0 breast cancer treated with mastectomy: a nationwide registry study to provide insight into prognosis

Author

De Wild, Sabine, van Roozendaal, Lori, de Wilt, Hans, van Dalen, Thijs, van der Hage, Jos, van Duijnhoven, Frederieke, Simons, Janine, Schipper, Robert-Jan, de Munck, Linda, van Kuijk, Sander, Boersma, Liesbeth, Linn, Sabine, Lobbes, Marc, Poortmans, Philip, Tjan-Heijnen, Vivianne, van de Vijver, Koen, de Vries, Jolanda, Westenberg, Helen, Strobbe, Luc, and Smidt, Marjolein

Published
2024
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41. Clinical impact of molecular breast imaging as adjunct diagnostic modality in evaluation of indeterminate breast abnormalities and unresolved diagnostic concerns

Author

van Loevezijn, Ariane A., primary, Corion, Christinne L.S., additional, Zeillemaker, Anneke M., additional, Wijers, Lidy M.H., additional, Smithuis, Robin H.M., additional, Valdés Olmos, Renato A., additional, van der Hage, Jos A., additional, de Geus-Oei, Lioe-Fee, additional, Benard, Menno, additional, and Pereira Arias-Bouda, Lenka M., additional

Published
2023
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42. Clinical evaluation of the clinicopathologic and gene expression profile (CP-GEP) in patients with melanoma eligible for sentinel lymph node biopsy:A multicenter prospective Dutch study

Author

Stassen, Robert C., Mulder, Evalyn E.A.P., Mooyaart, Antien L., Francken, Anne Brecht, van der Hage, Jos, Aarts, Maureen J.B., van der Veldt, Astrid A.M., Verhoef, Cornelis, Grünhagen, Dirk J., Stassen, Robert C., Mulder, Evalyn E.A.P., Mooyaart, Antien L., Francken, Anne Brecht, van der Hage, Jos, Aarts, Maureen J.B., van der Veldt, Astrid A.M., Verhoef, Cornelis, and Grünhagen, Dirk J.

Abstract

Sentinel lymph node biopsy (SLNB) is recommended for patients with >pT1b cutaneous melanoma, and should be considered and discussed with patients diagnosed with pT1b cutaneous melanoma for the purpose of staging, prognostication and determining eligibility for adjuvant therapy. Previously, the clinicopathologic and gene expression profile (CP-GEP, Merlin Assay®) model was developed to identify patients who can forgo SLNB because of a low risk for sentinel node metastasis. The aim of this study was to evaluate the clinical use and implementation of the CP-GEP model in a prospective multicenter study in the Netherlands. Both test performance and feasibility for clinical implementation were assessed in 260 patients with T1-T4 melanoma. The CP-GEP model demonstrated an overall negative predictive value of 96.7% and positive predictive value of 23.7%, with a potential SLNB reduction rate of 42.2% in patients with T1-T3 melanoma. With a median time of 16 days from initiation to return of test results, there was sufficient time left before the SLNB was performed. Based on these outcomes, the model may support clinical decision-making to identify patients who can forgo SLNB in clinical practice.

Published
2023

43. Local treatment in metastatic GIST patients:A multicentre analysis from the Dutch GIST Registry

Author

Brink, Pien, Kalisvaart, Gijsbert M., Schrage, Yvonne M., Mohammadi, Mahmoud, Ijzerman, Nikki S., Bleckman, Roos F., Wal, Tom, de Geus-Oei, Lioe Fee, Hartgrink, Henk H., Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Oosten, Astrid W., Been, Lukas B., van Ginkel, Robert J., Reyners, An K.L., Bonenkamp, Han J., Desar, Ingrid M.E., Gelderblom, Hans, van Houdt, Winan J., Steeghs, Neeltje, Fiocco, Marta, van der Hage, Jos A., Brink, Pien, Kalisvaart, Gijsbert M., Schrage, Yvonne M., Mohammadi, Mahmoud, Ijzerman, Nikki S., Bleckman, Roos F., Wal, Tom, de Geus-Oei, Lioe Fee, Hartgrink, Henk H., Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Oosten, Astrid W., Been, Lukas B., van Ginkel, Robert J., Reyners, An K.L., Bonenkamp, Han J., Desar, Ingrid M.E., Gelderblom, Hans, van Houdt, Winan J., Steeghs, Neeltje, Fiocco, Marta, and van der Hage, Jos A.

Abstract

Background: The added value of local treatment in selected metastatic GIST patients is unclear. This study aims to provide insight into the usefulness of local treatment in metastatic GIST by use of a survey study and retrospective analyses in a clinical database. Methods: A survey study was conducted among clinical specialists to select most relevant characteristics of metastatic GIST patients considered for local treatment, defined as elective surgery or ablation. Patients were selected from the Dutch GIST Registry. A multivariate Cox-regression model for overall survival since time of diagnosis of metastatic disease was estimated with local treatment as a time-dependent variable. An additional model was estimated to assess prognostic factors since local treatment. Results: The survey's response rate was 14/16. Performance status, response to TKIs, location of active disease, number of lesions, mutation status, and time between primary diagnosis and metastases, were regarded the 6 most important characteristics. Of 457 included patients, 123 underwent local treatment, which was associated with better survival after diagnosis of metastases (HR = 0.558, 95%CI = 0.336–0.928). Progressive disease during systemic treatment (HR = 3.885, 95%CI = 1.195–12.627) and disease confined to the liver (HR = 0.269, 95%CI = 0.082–0.880) were associated with worse and better survival after local treatment, respectively. Conclusion: Local treatment is associated with better survival in selected patients with metastatic GIST. Locally treated patients with response to TKIs and disease confined to the liver have good clinical outcome. These results might be considered for tailoring treatment, but should be interpreted with care because only specific patients are provided with local treatment in this retrospective study.

Published
2023

44. Preservation of the Pectoral Fascia in Mastectomy With Immediate Reconstruction:A Nationwide Survey

Author

Blok, Yara Lynn, Suijker, Jaco, van den Tol, Monique P., van der Pol, Carmen C., Mureau, Marc A.M., van der Hage, Jos A., Krekel, Nicole M.A., Blok, Yara Lynn, Suijker, Jaco, van den Tol, Monique P., van der Pol, Carmen C., Mureau, Marc A.M., van der Hage, Jos A., and Krekel, Nicole M.A.

Abstract

Introduction: Pectoral fascia (PF) removal during mastectomy still seems to be the standard procedure. However, preservation of the PF might improve postoperative and cosmetic outcomes, without compromising oncological safety. Here, we report on a national survey among Dutch plastic surgeons and oncological breast surgeons to evaluate their techniques and opinions regarding the PF. Materials and methods: A survey based study was performed in the Netherlands, in which both plastic surgeons and oncological breast surgeons were included, each receiving a different version of the survey. The surveys were distributed to 460 and 150 e-mail addresses, respectively. Results: A total of 68 responses were included from more than half of all Dutch medical centers. The results of this study indicate that circa one in five plastic surgeons and breast surgeons routinely preserve the PF during mastectomies and even more surgeons preserve the PF in specific cases. The surgical techniques and opinions regarding PF preservation widely differ between surgeons. Conclusions: Preservation of the PF does occur in a substantial part of the Dutch medical centers and techniques and opinions are contradictory. Future studies on this topic should clarify the effect of PF preservation on oncological safety, complication rates, postoperative pain, cosmetic outcomes, and patient satisfaction.

Published
2023

45. Neoadjuvant Cytoreductive Treatment of Regionally Advanced Melanoma With BRAF/MEK Inhibition: Study Protocol of the REDUCTOR (Cytoreductive Treatment of Dabrafenib Combined With Trametinib to Allow Complete Surgical Resection in Patients With BRAF Mutated, Prior Unresectable Stage III or IV Melanoma) Trial

Author

Madu, Max F., Rozeman, E.A. Lisette, van der Hage, Jos A., Wouters, Michel W.J.M., Klop, W. Martin C., van Thienen, J.V. Hans, Blank, Christian U., Haanen, John B.A.G., and van Akkooi, Alexander C.J.

Published
2016
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50. Systemic Therapy in Advanced Nodular Melanoma versus Superficial Spreading Melanoma: A Nation-Wide Study of the Dutch Melanoma Treatment Registry

Author

Rauwerdink, Daan Jan Willem, primary, van Doorn, Remco, additional, van der Hage, Jos, additional, Van den Eertwegh, Alfonsus J. M., additional, Haanen, John B. A. G., additional, Aarts, Maureen, additional, Berkmortel, Franchette, additional, Blank, Christian U., additional, Boers-Sonderen, Marye J., additional, De Groot, Jan Willem B., additional, Hospers, Geke A. P., additional, de Meza, Melissa, additional, Piersma, Djura, additional, Van Rijn, Rozemarijn S., additional, Stevense, Marion, additional, Van der Veldt, Astrid, additional, Vreugdenhil, Gerard, additional, Wouters, Michel W. J. M., additional, Suijkerbuijk, Karijn, additional, van der Kooij, Monique, additional, and Kapiteijn, Ellen, additional

Published
2022
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