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2. A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients

Author

Pazan, Farhad, Petrovic, Mirko, Cherubini, Antonio, Cruz-Jentoft, Alfonso J., Denkinger, Michael, van der Cammen, Tischa J. M., Stevenson, Jennifer M., Ibrahim, Kinda, Rajkumar, Chakravarthi, Bakken, Marit Stordal, Crome, Peter, Guðmundsson, Adalsteinn, Knol, Wilma, Snijders, Birgitta M. G., O’Mahony, Denis, Serra-Rexach, José Antonio, Soulis, George, van Marum, Rob J., Ziere, Gijsbertus, Mair, Alpana, Burkhardt, Heinrich, Neumann-Podczaska, Agnieszka, Wieczorowska-Tobis, Katarzyna, Fernandes, Marilia Andreia, Gruner, Heidi, van der Velde, Nathalie, and Wehling, Martin

Published
2022
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4. Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials

Author

Pazan, Farhad, Petrovic, Mirko, Cherubini, Antonio, Onder, Graziano, Cruz-Jentoft, Alfonso J., Denkinger, Michael, van der Cammen, Tischa J. M., Stevenson, Jennifer M., Ibrahim, Kinda, Rajkumar, Chakravarthi, Bakken, Marit Stordal, Baeyens, Jean-Pierre, Crome, Peter, Frühwald, Thomas, Gallaghar, Paul, Guðmundsson, Adalsteinn, Knol, Wilma, O’Mahony, Denis, Pilotto, Alberto, Rönnemaa, Elina, Serra-Rexach, José Antonio, Soulis, George, van Marum, Rob J., Ziere, Gijsbertus, Mair, Alpana, Burkhardt, Heinrich, Neumann-Podczaska, Agnieszka, Wieczorowska-Tobis, Katarzyna, Fernandes, Marilia Andreia, Gruner, Heidi, Dallmeier, Dhayana, Beuscart, Jean-Baptiste, van der Velde, Nathalie, and Wehling, Martin

Published
2021
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7. Correction to: Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials

Author

Pazan, Farhad, Petrovic, Mirko, Cherubini, Antonio, Onder, Graziano, Cruz-Jentoft, Alfonso J., Denkinger, Michael, van der Cammen, Tischa J. M., Stevenson, Jennifer M., Ibrahim, Kinda, Rajkumar, Chakravarthi, Bakken, Marit Stordal, Baeyens, Jean-Pierre, Crome, Peter, Frühwald, Thomas, Gallaghar, Paul, Guðmundsson, Adalsteinn, Knol, Wilma, O’Mahony, Denis, Pilotto, Alberto, Rönnemaa, Elina, Serra-Rexach, José Antonio, Soulis, George, van Marum, Rob J., Ziere, Gijsbertus, Mair, Alpana, Burkhardt, Heinrich, Neumann-Podczaska, Agnieszka, Wieczorowska-Tobis, Katarzyna, Fernandes, Marilia Andreia, Gruner, Heidi, Dallmeier, Dhayana, Beuscart, Jean-Baptiste, van der Velde, Nathalie, and Wehling, Martin

Published
2021
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8. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

Author

Palmer, Katie, Villani, Emanuele R., Vetrano, Davide L., Cherubini, Antonio, Cruz-Jentoft, Alfonso J., Curtin, Denis, Denkinger, Michael, Gutiérrez-Valencia, Marta, Guðmundsson, Adalsteinn, Knol, Wilma, Mak, Diane V., O’Mahony, Denis, Pazan, Farhad, Petrovic, Mirko, Rajkumar, Chakravarthi, Topinkova, Eva, Trevisan, Catarina, van der Cammen, Tischa J. M., van Marum, Rob J., Wehling, Martin, Ziere, Gijsbertus, Bernabei, Roberto, Onder, Graziano, and On behalf of the European Geriatric Medicine Society Pharmacology special interest group

Published
2019
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11. Validation of the ADFICE_IT Models for Predicting Falls and Recurrent Falls in Geriatric Outpatients

Author

MS Geriatrie, Circulatory Health, van de Loo, Bob, Heymans, Martijn W, Medlock, Stephanie, Boyé, Nicole D A, van der Cammen, Tischa J M, Hartholt, Klaas A, Emmelot-Vonk, Marielle H, Mattace-Raso, Francesco U S, Abu-Hanna, Ameen, van der Velde, Nathalie, van Schoor, Natasja M, MS Geriatrie, Circulatory Health, van de Loo, Bob, Heymans, Martijn W, Medlock, Stephanie, Boyé, Nicole D A, van der Cammen, Tischa J M, Hartholt, Klaas A, Emmelot-Vonk, Marielle H, Mattace-Raso, Francesco U S, Abu-Hanna, Ameen, van der Velde, Nathalie, and van Schoor, Natasja M

Published
2023

13. Validation of the ADFICE_IT Models for Predicting Falls and Recurrent Falls in Geriatric Outpatients

Author

van de Loo, Bob, Heymans, Martijn W., Medlock, Stephanie, Boyé, Nicole D. A., van der Cammen, Tischa J. M., Hartholt, Klaas A., Emmelot-Vonk, Marielle H., Mattace-Raso, Francesco U. S., Abu-Hanna, Ameen, van der Velde, Nathalie, and van Schoor, Natasja M.

Abstract

Objectives: Before being used in clinical practice, a prediction model should be tested in patients whose data were not used in model development. Previously, we developed the ADFICE_IT models for predicting any fall and recurrent falls, referred as Any_fall and Recur_fall. In this study, we externally validated the models and compared their clinical value to a practical screening strategy where patients are screened for falls history alone. Design: Retrospective, combined analysis of 2 prospective cohorts. Setting and Participants: Data were included of 1125 patients (aged ≥65 years) who visited the geriatrics department or the emergency department. Methods: We evaluated the models' discrimination using the C-statistic. Models were updated using logistic regression if calibration intercept or slope values deviated significantly from their ideal values. Decision curve analysis was applied to compare the models’ clinical value (ie, net benefit) against that of falls history for different decision thresholds. Results: During the 1-year follow-up, 428 participants (42.7%) endured 1 or more falls, and 224 participants (23.1%) endured a recurrent fall (≥2 falls). C-statistic values were 0.66 (95% CI 0.63-0.69) and 0.69 (95% CI 0.65-0.72) for the Any_fall and Recur_fall models, respectively. Any_fall overestimated the fall risk and we therefore updated only its intercept whereas Recur_fall showed good calibration and required no update. Compared with falls history, Any_fall and Recur_fall showed greater net benefit for decision thresholds of 35% to 60% and 15% to 45%, respectively. Conclusions and Implications: The models performed similarly in this data set of geriatric outpatients as in the development sample. This suggests that fall-risk assessment tools that were developed in community-dwelling older adults may perform well in geriatric outpatients. We found that in geriatric outpatients the models have greater clinical value across a wide range of decision thresholds compared with screening for falls history alone.

Published
2023
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20. Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

Author

Enneman, Anke W., Swart, Karin M. A., van Wijngaarden, Janneke P., van Dijk, Suzanne C., Ham, Annelies C., Brouwer-Brolsma, Elske M., van der Zwaluw, Nikita L., Dhonukshe-Rutten, Rosalie A. M., van der Cammen, Tischa J. M., de Groot, Lisette C. P. G. M., van Meurs, Joyce, Lips, Paul, Uitterlinden, André G., Zillikens, M. Carola, van Schoor, Natasja M., and van der Velde, Nathalie

Published
2015
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21. The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults

Author

Koelé, Marije C, primary, Willems, Hanna C, additional, Harmsen, Iris M, additional, Swart, Karin M A, additional, van Dijk, Suzanne C, additional, Lips, Paul, additional, de Groot, Lisette C P G M, additional, van der Cammen, Tischa J M, additional, Zillikens, M Carola, additional, van Schoor, Natasja M, additional, and van der Velde, Nathalie, additional

Published
2022
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24. Associations Between Medication Use and Homocysteine Levels in an Older Population, and Potential Mediation by Vitamin B12 and Folate: Data from the B-PROOF Study

Author

Ham, Annelies C., Enneman, Anke W., van Dijk, Suzanne C., Oliai Araghi, Sadaf, Swart, Karin M. A., Sohl, Evelien, van Wijngaarden, Janneke P., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., Dhonukshe-Rutten, Rosalie A. M., van Schoor, Natasja M., van der Cammen, Tischa J. M., Zillikens, M. Carola, de Jonge, Robert, Lips, Paul, de Groot, Lisette C. P. G. M., van Meurs, Joyce B. J., Uitterlinden, André G., Witkamp, Renger F., Stricker, Bruno H. C., and van der Velde, Nathalie

Published
2014
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29. Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study

Author

Ham, Annelies C., Swart, Karin M. A., Enneman, Anke W., van Dijk, Suzanne C., Araghi, Sadaf Oliai, van Wijngaarden, Janneke P., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., Dhonukshe-Rutten, Rosalie A. M., van Schoor, Natasja M., van der Cammen, Tischa J. M., Lips, Paul, de Groot, Lisette C. P. G. M., Uitterlinden, André G., Witkamp, Renger F., Stricker, Bruno H., and van der Velde, Nathalie

Published
2014
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39. Assessment and treatment of malnutrition in Dutch geriatric practice: consensus through a modified Delphi study

Author

van Asselt, Dieneke Z. B., van Bokhorst-de van der Schueren, Marian A. E., van der Cammen, Tischa J. M., Disselhorst, Luc G. M., Janse, Andre, Lonterman-Monasch, Sabine, Maas, Huub A. A. M., Popescu, Miruna E., Schölzel-Dorenbos, Carla J. M., Sipers, Walter M. W. H., Veldhoven, Carel M. M., Wijnen, Hugo H., and Olde Rikkert, Marcel G. M.

Published
2012
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40. STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk): a Delphi study by the EuGMS Task and Finish Group on Fall-Risk-Increasing Drugs

Author

Seppala, Lotta J, primary, Petrovic, Mirko, additional, Ryg, Jesper, additional, Bahat, Gulistan, additional, Topinkova, Eva, additional, Szczerbińska, Katarzyna, additional, van der Cammen, Tischa J M, additional, Hartikainen, Sirpa, additional, Ilhan, Birkan, additional, Landi, Francesco, additional, Morrissey, Yvonne, additional, Mair, Alpana, additional, Gutiérrez-Valencia, Marta, additional, Emmelot-Vonk, Marielle H, additional, Mora, María Ángeles Caballero, additional, Denkinger, Michael, additional, Crome, Peter, additional, Jackson, Stephen H D, additional, Correa-Pérez, Andrea, additional, Knol, Wilma, additional, Soulis, George, additional, Gudmundsson, Adalsteinn, additional, Ziere, Gijsbertus, additional, Wehling, Martin, additional, O’Mahony, Denis, additional, Cherubini, Antonio, additional, and van der Velde, Nathalie, additional

Published
2020
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41. Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials

Author

Pazan, Farhad, primary, Petrovic, Mirko, additional, Cherubini, Antonio, additional, Onder, Graziano, additional, Cruz-Jentoft, Alfonso J., additional, Denkinger, Michael, additional, van der Cammen, Tischa J. M., additional, Stevenson, Jennifer M., additional, Ibrahim, Kinda, additional, Rajkumar, Chakravarthi, additional, Bakken, Marit Stordal, additional, Baeyens, Jean-Pierre, additional, Crome, Peter, additional, Frühwald, Thomas, additional, Gallaghar, Paul, additional, Guðmundsson, Adalsteinn, additional, Knol, Wilma, additional, O’Mahony, Denis, additional, Pilotto, Alberto, additional, Rönnemaa, Elina, additional, Serra-Rexach, José Antonio, additional, Soulis, George, additional, van Marum, Rob J., additional, Ziere, Gijsbertus, additional, Mair, Alpana, additional, Burkhardt, Heinrich, additional, Neumann-Podczaska, Agnieszka, additional, Wieczorowska-Tobis, Katarzyna, additional, Fernandes, Marilia Andreia, additional, Gruner, Heidi, additional, Dallmeier, Dhayana, additional, Beuscart, Jean-Baptiste, additional, van der Velde, Nathalie, additional, and Wehling, Martin, additional

Published
2020
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43. Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients

Author

Egberts, Angelique, Osse, Robert J, Fekkes, Durk, Tulen, Joke H M, van der Cammen, Tischa J M, and Mattace-Raso, Francesco U S

Subjects
Aged, 80 and over, Male, renal function, Delirium, Homovanillic Acid, Middle Aged, Neopterin, Oxidative Stress, C-Reactive Protein, immune system diseases, inflammation, Elective Surgical Procedures, Clinical Interventions in Aging, Linear Models, Humans, Female, Amino Acids, Cardiac Surgical Procedures, Biomarkers, Original Research, Aged
Abstract

Angelique Egberts,1 Robert J Osse,2 Durk Fekkes,2,3 Joke HM Tulen,2 Tischa JM van der Cammen,1 Francesco US Mattace-Raso1 1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; 2Department of Psychiatry, Erasmus MC University Medical Center, Rotterdam, the Netherlands; 3Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, the Netherlands Background/aims: The pathophysiology of delirium is poorly understood. Increasing evidence suggests that different pathways might be involved in the pathophysiology depending on the population studied. The aim of the present study was to investigate potential differences in mean plasma levels of neopterin, amino acids, amino acid ratios and homovanillic acid between two groups of patients with delirium.Methods: Data from acutely ill medical patients aged 65 years and older, and patients aged 70 years and older undergoing elective cardiac surgery, were used. Differences in biomarker levels between the groups were investigated using univariate ANOVA with adjustments for age, sex, comorbidities, C-reactive protein (CRP) and the estimated glomerular filtration rate (eGFR), where appropriate. Linear regression analysis was used to identify potential determinants of the investigated biochemical markers.Results: Eighty patients with delirium were included (23 acutely ill medical patients and 57 elective cardiac surgery patients). After adjustment, higher mean neopterin levels (93.1 vs 47.3 nmol/L, P=0.001) and higher phenylalanine/tyrosine ratios (1.39 vs 1.15, P=0.032) were found in acutely ill medical patients when compared to elective cardiac surgery patients. CRP levels were positively correlated with neopterin levels in acutely ill medical patients, explaining 28.4% of the variance in neopterin levels. eGFR was negatively correlated with neopterin in elective cardiac surgery patients, explaining 53.7% of the variance in neopterin levels.Conclusion: In this study, we found differences in mean neopterin levels and phenylalanine/tyrosine ratios between acutely ill medical and elective cardiac surgery patients with delirium. Moreover, our findings may suggest that in acutely ill medical patients, neopterin levels are mainly determined by inflammation/oxidative stress whereas in elective cardiac surgery patients, neopterin levels are mainly driven by renal function/fluid status. These findings suggest that the markers and pathways that might be involved in the pathophysiology of delirium may differ between specific groups of patients. Keywords: delirium, inflammation, neopterin, oxidative stress, renal function

Published
2019

44. Converting wandering behaviour into a guided activity: a case study of co-designing with People Living with Dementia based on theoretical models

Author

Wang, Gubing, Albayrak, Armagan, and van der Cammen, Tischa J. M.

Subjects
ddc:621.3, ddc:620, Demenz, MinD Conference, Pflegeheim, Verhaltens- und psychologische Symptome der Demenz, Körperliche Aktivität, Demenzpflege, Dementia, MinD Conference, Nursing Home, Behavioural and Psychological Symptoms of Dementia, Physical Activity, Dementia Care
Abstract

For People Living with Dementia (PLwD), wandering behaviour can cause undesired consequences, such as falling, getting lost or even fatalities. For caregivers, taking care of PLwD with wandering behaviours is burdensome. If not intervened early, some wandering behaviours will escalate into crisis events. This design research aims to explore how to convert the wandering behaviour to a guided activity with the minimum input from caregivers by intervening early, that is, engaging PLwD, to avoid potential escalations. Based on Need-driven Dementia-compromised Behaviour (NDB) model, Crisis Development model and via a co-design approach, we developed De-light. De-light is a set of interactive sticks enhanced by light, audio and tactile experiences. Based on the degree of wandering behaviours of PLwD, De-light can be placed by the caregiver in a safe and suitable area in the nursing home to provide a controlled setting for guiding PLwD to perform physical activity. Our design research implies the possibilities of applying NDB model, Crisis Development model, and co- design approach in designing for the wandering behaviours for PLwD.

Published
2019

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