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39 results on '"van der Bruggen, Tjomme"'

5. Impact of ciprofloxacin prophylaxis on blood stream infection during early treatment phase of pediatric acute lymphoblastic leukemia: An observational cohort study

Author

Infectiezieken, Infectieziekten patientenzorg, Infection & Immunity, Other research (not in main researchprogram), Scharloo, Fenna, Wolfs, Tom F.W., van der Bruggen, Tjomme, van der Sluis, Inge M., Tissing, Wim J.E., de Vrankrijker, Angelica M.M., Infectiezieken, Infectieziekten patientenzorg, Infection & Immunity, Other research (not in main researchprogram), Scharloo, Fenna, Wolfs, Tom F.W., van der Bruggen, Tjomme, van der Sluis, Inge M., Tissing, Wim J.E., and de Vrankrijker, Angelica M.M.

Published
2024

7. Clostridioides difficile infection with isolates of cryptic clade C-II: a genomic analysis of polymerase chain reaction ribotype 151

Author

MMB Medische Staf, Infection & Immunity, MS Hematologie, Cancer, Ducarmon, Quinten R., van der Bruggen, Tjomme, Harmanus, Céline, Sanders, Ingrid M.J.G., Daenen, Laura G.M., Fluit, Ad C., Vossen, Rolf H.A.M., Kloet, Susan L., Kuijper, Ed J., Smits, Wiep Klaas, MMB Medische Staf, Infection & Immunity, MS Hematologie, Cancer, Ducarmon, Quinten R., van der Bruggen, Tjomme, Harmanus, Céline, Sanders, Ingrid M.J.G., Daenen, Laura G.M., Fluit, Ad C., Vossen, Rolf H.A.M., Kloet, Susan L., Kuijper, Ed J., and Smits, Wiep Klaas

Published
2023

10. Clostridioides difficilePCR ribotype 151 is polyphyletic and includes pathogenic isolates from cryptic clade C-II with mono-toxin pathogenicity loci that can escape routine diagnostics

Author

Ducarmon, Quinten R., primary, van der Bruggen, Tjomme, additional, Harmanus, Céline, additional, Sanders, Ingrid M.J.G., additional, Daenen, Laura G.M., additional, Fluit, Ad C., additional, Vossen, Rolf H.A.M., additional, Kloet, Susan L., additional, Kuijper, Ed J., additional, and Smits, Wiep Klaas, additional

Published
2022
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11. Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; an 11-year multi-centre retrospective study

Author

de la Court, Jara R, Woudt, Sjoukje H S, Schoffelen, Annelot F, Heijmans, Jarom, de Jonge, Nick A, van der Bruggen, Tjomme, Bomers, Marije K, Lambregts, Merel M C, Schade, Rogier P, and Sigaloff, Kim C E

Subjects
Third-generation-cephalosporin resistance, Febrile neutropenia, Colonization, Resistance surveillance, Antimicrobial resistance, Empirical antibiotic therapy
Abstract

Objectives Among patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of gram-negative pathogens to third-generation cephalosporins is increasing. We aimed to assess the distribution of pathogens causing bacteraemia in patients with haematological malignancy, and the proportion of 3GC-R GNB bacteraemia that was preceded by 3GC-R GNB colonization. Methods Using 11 years of data (2008–2018) from the Dutch national antimicrobial resistance surveillance system, we assessed the prevalence of third-generation cephalosporin resistant Gram-negative bacteria (3GC-R GNB) in episodes of bacteraemia, and the proportion of 3GC-R GNB bacteraemia that was preceded by 3GC-R GNB colonization (identified using surveillance cultures) in the year before. Results We included 3,887 patients, representing 4,142 episodes of bacteraemia. GNB were identified in 715/4,142 (17.3%), of which 221 (30.9%) were 3GC-R GNB. In (106/139) 76.2% of patients with a 3GC-R GNB bacteraemia and available GNB surveillance cultures in the preceding year, 3GC-R GNB colonization had been previously identified. Conclusions This multi-centre study shows that in patients with haematological malignancy, the majority of 3GC-R GNB bacteraemia is preceded by 3GC-R GNB colonization. Prospective clinical studies are needed to assess the safety and benefits of surveillance-culture guided empirical therapy to restrict the empirical use of carbapenems in this population.

Published
2022
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12. Mucormycosis in Children With Hematologic Malignancies: A Case Series and Review of the Literature

Author

Loeffen, Yvette G T, Scharloo, Fenna, Goemans, Bianca F, Heitink-Polle, Katja M J, Lindemans, Caroline A, van der Bruggen, Tjomme, Hagen, Ferry, Wolfs, Tom F W, Loeffen, Yvette G T, Scharloo, Fenna, Goemans, Bianca F, Heitink-Polle, Katja M J, Lindemans, Caroline A, van der Bruggen, Tjomme, Hagen, Ferry, and Wolfs, Tom F W

Abstract

BACKGROUND: Mucormycosis is classified as the third leading cause of invasive fungal disease in immunocompromised patients and is characterized by high morbidity and mortality (33%-56%). The aim of this study is to describe presentation, treatment and outcome of Dutch pediatric hemato-oncology patients recently diagnosed with mucormycosis and to review the literature to gain more insight specifically into contemporary outcome data.METHODS: Ten cases were diagnosed in the Princess Máxima Center for Pediatric Oncology from 2018 to 2021 and were retrospectively reviewed. In addition, 9 case series (n = 148) were included from literature.RESULTS: In our case series, 5 patients of 10 children (age 2-17 years) had disseminated invasive fungal disease. Four patients had localized pulmonary disease and 1 had a localized renal infection. One diagnosis was made postmortem. The underlying diseases were acute lymphoblastic leukemia (n = 6), acute myeloid leukemia (n = 2) and lymphoma (n=2). Seven patients received combination therapy comprising of a lipid amphotericin B formulation and a triazole, surgery was performed in 67%. All neutropenic patients received granulocyte transfusions and/or granulocyte colony-stimulating factor. Mucormycosis-related mortality was 20%. In the literature review, mucormycosis-related mortality was 36% for all patients and 66% for patients with disseminated disease. Survival rates were similar over the past 2 decades. The most common underlying disorder was acute lymphoblastic leukemia. Liposomal amphotericin B was the mainstay of treatment. Seventy percent of patients underwent surgery.CONCLUSIONS: Although survival of mucormycosis improved significantly overtime, it plateaued in the past decades. This series shows that with screening, early diagnostics and early antifungal and if possible surgical treatment, mortality is low and even disseminated disease is salvageable if approached aggressively with a combination of surg

Published
2022

13. Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Author

Arts-assistenten Kinderen, Longziekten onderzoek 2, Child Health, CTI Meyaard, Genetica Groep Van Haaften, Cancer, Genetica Sectie Research, Onderzoek, Regenerative Medicine and Stem Cells, CTI, Infection & Immunity, CDL Patiëntenzorg MI, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, Bont, Louis J, Arts-assistenten Kinderen, Longziekten onderzoek 2, Child Health, CTI Meyaard, Genetica Groep Van Haaften, Cancer, Genetica Sectie Research, Onderzoek, Regenerative Medicine and Stem Cells, CTI, Infection & Immunity, CDL Patiëntenzorg MI, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, and Bont, Louis J

Published
2022

15. Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient

Author

Besteman, Sjanna B, primary, Phung, Emily, additional, Raeven, Henriette H M, additional, Amatngalim, Gimano D, additional, Rumpret, Matevž, additional, Crabtree, Juliet, additional, Schepp, Rutger M, additional, Rodenburg, Lisa W, additional, Siemonsma, Susanna G, additional, Verleur, Nile, additional, van Slooten, Rianne, additional, Duran, Karen, additional, van Haaften, Gijs W, additional, Beekman, Jeffrey M, additional, Chang, Lauren A, additional, Meyaard, Linde, additional, van der Bruggen, Tjomme, additional, Berbers, Guy A M, additional, Derksen, Nicole, additional, Nierkens, Stefan, additional, Morabito, Kaitlyn M, additional, Ruckwardt, Tracy J, additional, Kurt-Jones, Evelyn A, additional, Golenbock, Douglas, additional, Graham, Barney S, additional, and Bont, Louis J, additional

Published
2022
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24. Erratum to: The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida

Author

Zegers, Sebastiaan Hermanus Johannes, Dieleman, Jeanne, van der Bruggen, Tjomme, Kimpen, Jan, and de Jong-de Vos van Steenwijk, Catharine

Subjects
Male, Adolescent, Bacteriuria, Penicillins, Antibiotic Prophylaxis, Anti-Bacterial Agents, Aminoglycosides, Deprescriptions, Infectious Diseases, Nitrofurantoin, Drug Resistance, Bacterial, Trimethoprim, Sulfamethoxazole Drug Combination, Urinary Tract Infections, Escherichia coli, Humans, Female, Erratum, Child, Gram-Negative Bacterial Infections, Spinal Dysraphism, Escherichia coli Infections, Gram-Positive Bacterial Infections, Fluoroquinolones, Research Article
Abstract

Background Bacterial resistance to antibiotics is an increasingly threatening consequence of antimicrobial exposure for many decades now. In urinary tract infections (UTIs), antibiotic prophylaxis (AP) increases bacterial resistance. We studied the resistance patterns of positive urinary cultures in spina bifida children on clean intermittent catheterization, both continuing and stopping AP. Methods In a cohort of 176 spina bifida patients, 88 continued and 88 stopped using AP. During 18 months, a fortnightly catheterized urine sample for bacterial pathogens was cultured. UTIs and significant bacteriuria (SBU) were defined as a positive culture with a single species of bacteria, respectively with and without clinical symptoms and leukocyturia. We compared the percentage of resistance to commonly used antibiotics in the isolated bacteria in both groups. Results In a total of 4917 cultures, 713 (14.5%) had a positive monoculture, 54.3% of which were Escherichia coli. In the group stopping AP, the resistance percentage to antibiotics in UTI / SBU bacteria was lower than in the group remaining on AP, even when excluding the administered prophylaxis. Conclusion Stopping antibiotic prophylaxis for urinary tract infections is associated with reduced bacterial resistance to antibiotics in children with spina bifida. Trial registration ISRCTN ISRCTN56278131. Registered 20 December 2005.

Published
2017
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27. Cutaneotrichosporon (Cryptococcus) cyanovorans, a basidiomycetous yeast, isolated from the airways of cystic fibrosis patients

Author

Infection & Immunity, Longziekten patientenzorg, Child Health, van der Bruggen, Tjomme, Kolecka, Anna, Theelen, Bart, Kwakkel-van Erp, Johanna M., Arets, Bert, Boekhout, Teun, Infection & Immunity, Longziekten patientenzorg, Child Health, van der Bruggen, Tjomme, Kolecka, Anna, Theelen, Bart, Kwakkel-van Erp, Johanna M., Arets, Bert, and Boekhout, Teun

Published
2018

30. The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida.

Author

Johannes Zegers, Sebastiaan Hermanus, Dieleman, Jeanne, van der Bruggen, Tjomme, Kimpen, Jan, and de Jong-de Vos van Steenwijk, Catharine

Subjects
AMINOGLYCOSIDES, ANTIBIOTICS, ESCHERICHIA coli physiology, ESCHERICHIA coli disease prevention, URINARY tract infection prevention, PENICILLIN, QUINOLONE antibacterial agents, NITROFURANTOIN, COMPARATIVE studies, DRUG resistance in microorganisms, ESCHERICHIA coli, ESCHERICHIA coli diseases, GRAM-negative bacterial diseases, RESEARCH methodology, MEDICAL cooperation, RESEARCH, SPINA bifida, URINARY tract infections, EVALUATION research, GRAM-positive bacterial infections, RANDOMIZED controlled trials, ANTIBIOTIC prophylaxis, BACTERIURIA, DISEASE complications, PREVENTION, THERAPEUTICS
Abstract

Background: Bacterial resistance to antibiotics is an increasingly threatening consequence of antimicrobial exposure for many decades now. In urinary tract infections (UTIs), antibiotic prophylaxis (AP) increases bacterial resistance. We studied the resistance patterns of positive urinary cultures in spina bifida children on clean intermittent catheterization, both continuing and stopping AP.Methods: In a cohort of 176 spina bifida patients, 88 continued and 88 stopped using AP. During 18 months, a fortnightly catheterized urine sample for bacterial pathogens was cultured. UTIs and significant bacteriuria (SBU) were defined as a positive culture with a single species of bacteria, respectively with and without clinical symptoms and leukocyturia. We compared the percentage of resistance to commonly used antibiotics in the isolated bacteria in both groups.Results: In a total of 4917 cultures, 713 (14.5%) had a positive monoculture, 54.3% of which were Escherichia coli. In the group stopping AP, the resistance percentage to antibiotics in UTI / SBU bacteria was lower than in the group remaining on AP, even when excluding the administered prophylaxis.Conclusion: Stopping antibiotic prophylaxis for urinary tract infections is associated with reduced bacterial resistance to antibiotics in children with spina bifida.Trial Registration: ISRCTN ISRCTN56278131 . Registered 20 December 2005. [ABSTRACT FROM AUTHOR]

Published
2017
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