41 results on '"van den Hoogen FJA"'
Search Results
2. FDG-PET in the clinically negative neck in oral squamous cell carcinoma.
- Author
-
Wensing BM, Vogel WV, Marres HAM, Merkx MAW, Postema EJ, Oyen WJG, van den Hoogen FJA, Wensing, Bart M, Vogel, Wouter V, Marres, Henri A M, Merkx, Matthias A W, Postema, Ernst J, Oyen, Wim J G, and van den Hoogen, Frank J A
- Abstract
Objective: With improved diagnostic imaging techniques, it remains difficult to reduce occult metastatic disease in oral squamous cell carcinoma (SCC) to less than 20%. Therefore, supraomohyoid neck dissection (SOHND) still is a valuable staging procedure in these patients.Methods: Patients with clinically and ultrasonographically staged cN0 SCC of the oral cavity underwent FDG-PET before SOHND. Histologic examination of neck dissection specimens was used as a "gold standard."Results: Twenty-eight consecutive patients were included, representing 30 necks. Occult metastatic disease was found in 30% of SOHND specimens. Average diameter of metastatic deposits was 4.3 mm. Sensitivity, specificity, and accuracy of FDG-PET was 33%, 76%, and 63%, respectively.Conclusions: In patients with cN0 SCC of the oral cavity, FDG-PET does not contribute to the preoperative workup. FDG-PET does not replace SOHND as a staging procedure. [ABSTRACT FROM AUTHOR]- Published
- 2006
3. Botulinum toxin effect on salivary flow rate in children with cerebral palsy.
- Author
-
Jongerius PH, Rotteveel JJ, van Limbeek J, Gabreëls FJM, van Hulst K, van den Hoogen FJA, Jongerius, P H, Rotteveel, J J, van Limbeek, J, Gabreëls, F J M, van Hulst, K, and van den Hoogen, F J A
- Published
- 2004
- Full Text
- View/download PDF
4. Effect of botulinum toxin in the treatment of drooling: a controlled clinical trial.
- Author
-
Jongerius PH, van den Hoogen FJA, van Limbeek J, Gabrëëls FJ, van Hulst K, and Rotteveel JJ
- Abstract
OBJECTIVE: To investigate the clinical effectiveness of botulinum neurotoxin type A (BoNT) to reduce drooling in children with cerebral palsy (CP). METHODS: A controlled clinical trial was performed in which the results of single-dose BoNT injections in the submandibular glands were compared with treatment with scopolamine. Forty-five children who had CP and experienced severe drooling were enrolled. Drooling severity was measured at baseline, during application of scopolamine, and at different intervals after BoNT injections up to 24 weeks, using the Drooling Quotient (DQ), the Teacher Drooling Scale (TDS), and Visual Analog Scales (VAS). RESULTS: Drooling was reduced during scopolamine application as well as after BoNT injections. Compared with baseline, the mean DQ showed a significant decrease throughout the study. Greatest reductions were achieved 2 to 8 weeks after BoNT injection. No significant differences were found between scopolamine measurements and those up to 24 months after BoNT injection. Using VAS, parents recorded the effect on drooling in which significant differences were found between baseline VAS score and all follow-up assessments. According to our definition of 'success to therapy,' demanding a 2-point decrease on the TDS, 61.5% of patients responded to BoNT injections. Analysis of the DQ demonstrated a response rate of 53% of the patients to scopolamine and 48.7% to BoNT until 24 weeks after BoNT injections, the actual duration of this study. As a reaction to scopolamine, 71.1% of the patients had moderate to severe side effects. Only nonsevere, incidental side effects were reported after BoNT injections. CONCLUSIONS: During scopolamine application as well as after intraglandular BoNT injections, a clinically relevant reduction in drooling was achieved in children with CP, demonstrating maximum effect 2 to 8 weeks after injections. This is the first controlled clinical trial that confirmed a significant effect of BoNT injections in the treatment of drooling. General anesthesia was needed for all children. BoNT injections show fewer and less serious side effects than transdermal scopolamine treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
5. Screening for second primary lung cancer after treatment of laryngeal cancer.
- Author
-
Ritoe SC, Krabbe PFM, Jansen MMG, Festen J, Joosten FBM, Kaanders JHA, van den Hoogen FJA, Verbeek ALM, Marres HAM, Ritoe, Savitri C, Krabbe, Paul F M, Jansen, Margriet M G, Festen, Jan, Joosten, Frank B M, Kaanders, J Hans A M, van den Hoogen, Frank J A, Verbeek, André L M, and Marres, Henri A M
- Abstract
Objectives/hypothesis: As a result of smoking, patients who have received curative treatment for laryngeal cancer run a high risk of developing lung cancer. Therefore, these patients enter a screening program that aims to detect lung cancer at an asymptomatic stage. The study evaluated whether screening for lung cancer by means of regular chest x-ray examinations contributed to prolonging survival.Study Design: A longitudinal follow-up study was performed to analyze the survival of patients who had received curative treatment for squamous cell laryngeal cancer and developed lung cancer during the follow-up period.Methods: Patients with lung cancer were divided into two groups: 1) patients with asymptomatic screen-detected lung cancer and 2) patients with complaints indicating lung cancer, whose tumor was detected in the interval between screening examinations by chest x-ray films.Results: In the complete group of patients with laryngeal cancer, no prognostic factors could be identified for developing lung cancer. There was no prolongation of survival in the screen-detected asymptomatic lung cancer patients. The median survival of both groups was 56 months (P =.57). The date of detection of the lung cancer was clearly brought forward by screening; a difference of 8 months was found between the median detection date of the two groups (P <.001). There was no difference in tumor-specific mortality between the two groups.Conclusion: Screening by chest x-ray examination to detect lung cancer in an asymptomatic stage after curative treatment for squamous cell laryngeal cancer does not improve survival for patients who develop lung cancer. [ABSTRACT FROM AUTHOR]- Published
- 2002
6. Quantitative videofluoroscopy: a new evaluation tool for tracheoesophageal voice production.
- Author
-
van As CJ, Op de Coul BMR, van den Hoogen FJA, Koopmans-van Beinum FJ, and Hilgers FJM
- Published
- 2001
- Full Text
- View/download PDF
7. The Nijdam voice prosthesis: a self-retaining valveless voice prosthesis for vocal rehabilitation after total laryngectomy.
- Author
-
van den Hoogen FJA, Nijdam HF, Veenstra A, and Manni JJ
- Published
- 1996
8. Interdisciplinary assessment and treatment of paediatric drooling: two decades of experience by the Nijmegen saliva control team reflected in a stepwise algorithm.
- Author
-
Orriëns LB, de Groot SAF, van der Burg JJW, van den Hoogen FJA, van Hulst K, and Erasmus CE
- Subjects
- Humans, Child, Patient Care Team, Child, Preschool, Netherlands, Clinical Decision-Making methods, Adolescent, Neurodevelopmental Disorders therapy, Neurodevelopmental Disorders complications, Neurodevelopmental Disorders diagnosis, Male, Female, Infant, Sialorrhea therapy, Sialorrhea etiology, Algorithms
- Abstract
Anterior and posterior drooling are prevalent comorbidities in children with neurodevelopmental disabilities. Considering the heterogeneity of the patient population and the multifactorial aetiology of drooling, an interdisciplinary and individualised treatment approach is indispensable. However, no tool for stepwise decision-making in the treatment of paediatric drooling has been developed previously. Within the Radboudumc Amalia Children's Hospital, care for children with anterior and/or posterior drooling secondary to neurodevelopmental disabilities is coordinated by a saliva control team with healthcare professionals from six disciplines. In alignment with international literature, published guidelines, and evidence gained from two decades of experience and research by our team, this paper proposes an algorithm reflecting the assessment and treatment approach applied in our clinic. First, directions are provided to decide on the necessity of saliva control treatment, taking type of drooling, the child's age, and the severity and impact of drooling into account. Second, the algorithm offers guidance on the choice between available treatment options, highlighting the importance of accounting for child characteristics and child and caregiver preferences in clinical (shared) decision-making., Conclusions: With this algorithm, we aim to emphasise the importance of repeated stepwise decision-making in the assessment and treatment of drooling in children during their childhood, encouraging healthcare professionals to apply a holistic approach., What Is Known: • Children with anterior or posterior drooling secondary to neurodevelopmental disabilities comprise a heterogeneous group, necessitating an individualised treatment approach. • No stepwise decision-making tool is available for the treatment of paediatric drooling., What Is New: • Deciding on the necessity of saliva control treatment should be a conscious process, based on type of drooling, age, and drooling severity and impact. • Type of drooling, age, cognition, oral motor skills, self-awareness, posture, diagnosis, and child/caregiver preferences need to be considered to decide on the optimal treatment., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
9. Virtue ethics, the next step in quality improvement?
- Author
-
Verstegen PMB, Kole JJ, Groenewoud AS, and van den Hoogen FJA
- Subjects
- Humans, Quality Improvement, Virtues
- Published
- 2024
- Full Text
- View/download PDF
10. Predicting non-response to intraglandular botulinum neurotoxin A injections for drooling in children with neurodevelopmental disabilities.
- Author
-
Orriëns LB, van Hulst K, Willemsen MAAP, van den Hoogen FJA, and Erasmus CE
- Subjects
- Humans, Male, Female, Child, Child, Preschool, Adolescent, Retrospective Studies, Neuromuscular Agents administration & dosage, Neuromuscular Agents pharmacology, Cerebral Palsy complications, Cerebral Palsy drug therapy, Parotid Gland, Sialorrhea drug therapy, Sialorrhea etiology, Botulinum Toxins, Type A administration & dosage, Botulinum Toxins, Type A pharmacology, Neurodevelopmental Disorders, Submandibular Gland drug effects
- Abstract
Aim: To develop robust multivariable prediction models for non-response to (1) submandibular botulinum neurotoxin A (BoNT-A) injections and (2) concurrent submandibular and parotid (four-gland) injections, to guide treatment decisions for drooling in children with neurodevelopmental disabilities, including cerebral palsy., Method: This was a retrospective cohort study including 262 children (155 males/107 females, median age 7 years 11 months [IQR 5 years 1 month], range 4 years 0 months - 17 years 11 months) receiving submandibular injections and 74 children (52 males/22 females, median age 7 years 7 months [IQR 4 years 3 months], range 4 years 9 months - 18 years 8 months) receiving four-gland injections. Multivariable logistic regression analyses were used to estimate associations between candidate predictors and non-response 8 weeks after injection., Results: Ninety-six children (37%) were non-responders to submandibular injections, for which developmental age was the strongest predictor (adjusted odds ratio [aOR] 2.13; 95% confidence interval [CI] 1.02-4.45 for developmental age <4 years or 4-6 years with IQ <70). Other characteristics that showed a trend towards an increased risk of non-response were diagnosis, sex, and head position. Thirty-four children (46%) were non-responders to four-gland injections, for which tongue protrusion (aOR 3.10; 95% CI 1.14-8.43) seemed most predictive, whereas multiple preceding submandibular injections (aOR 0.34; 95% CI 0.10-1.16) showed a trend towards being protective. Predictors were, however, unstable across different definitions of non-response and both models (i.e. submandibular and four-gland) had insufficient discriminative ability., Interpretation: Potential predictors of non-response to BoNT-A injections were identified. Nevertheless, the developed prediction models seemed inadequate for guidance of treatment decisions., What This Paper Adds: Developmental age seemed most predictive of non-response to submandibular botulinum neurotoxin A injections. Non-response to concurrent submandibular and parotid injections was best predicted by tongue protrusion and number of previous injections. Multivariable prediction models including these clinical characteristics were unable to discriminate well. Predictors differed when non-response was defined using alternative outcome measures., (© 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)
- Published
- 2024
- Full Text
- View/download PDF
11. The when, why, and how of using glycopyrronium to diminish drooling in children with neurodevelopmental disabilities: Implications for clinical practice.
- Author
-
Orriëns LB, van der Burg JJW, van den Hoogen FJA, Willemsen MAAP, van Hulst K, and Erasmus CE
- Abstract
Background: Despite the established efficacy of glycopyrronium bromide in reducing drooling among children with neurodevelopmental disabilities, evidence on its impact on the daily lives of children and parents and effectiveness in a real-world setting are scarce, especially among long-term users. This study explored timing and duration of glycopyrronium treatment, effect and impact on daily life, and occurrence of side effects to inform clinical practice., Methods: This was a retrospective cohort study at a national referral centre for drooling, including 61 children with nonprogressive neurodevelopmental disabilities, treated with glycopyrronium for anterior and/or posterior drooling between 2011 and 2021. Data were obtained from medical records and supplemented by structured telephone interviews with parents., Results: Anterior drooling severity decreased in 82% of the included children. Changes in the impact of drooling on burden of care, social interaction, and self-esteem were reported in 55%, 31%, and 36%, respectively. Side effects were noted for 71% of cases, yet only 36% of parents deemed these as outweighing the positive impact of treatment. A substantial majority (77%) of the included children were long-term users (≥6 months). Among these, 38% of parents reported decreasing effectiveness and 27% noticed more prominent side effects over time., Conclusions: Glycopyrronium demonstrated potential in mitigating the impact of drooling on daily life, although variations were observed in the specific aspects and extent of improvement. The real-world context of our study provides important insights for refining clinical practices, emphasizing the need for balanced consideration of treatment benefits and potential side effects to facilitate shared decision-making., Competing Interests: Declaration of competing interest Karen van Hulst and Corrie Erasmus have received a consulting fee from Eurocept Pharmaceuticals. Corrie Erasmus has received an unrestricted research grant from Proveca Ltd. All funding was paid to their institution and embedded in a research foundation; they received no personal financial payment. The other authors have no relevant financial or non-financial interest to disclose., (© 2024 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.)
- Published
- 2024
- Full Text
- View/download PDF
12. Comparing the evidence for botulinum neurotoxin injections in paediatric anterior drooling: a scoping review.
- Author
-
Orriëns LB, van Hulst K, van der Burg JJW, van den Hoogen FJA, Willemsen MAAP, and Erasmus CE
- Subjects
- Humans, Child, Neurotoxins pharmacology, Neurotoxins therapeutic use, Submandibular Gland, Treatment Outcome, Sialorrhea drug therapy, Sialorrhea etiology, Botulinum Toxins, Type A therapeutic use, Botulinum Toxins, Type A pharmacology
- Abstract
Paediatric anterior drooling has a major impact on the daily lives of children and caregivers. Intraglandular botulinum neurotoxin type-A (BoNT-A) injections are considered an effective treatment to diminish drooling. However, there is no international consensus on which major salivary glands should be injected to obtain optimal treatment effect while minimizing the risk of side effects. This scoping review aimed to explore the evidence for submandibular BoNT-A injections and concurrent submandibular and parotid (i.e. four-gland) injections, respectively, and assess whether outcomes could be compared across studies to improve decision making regarding the optimal initial BoNT-A treatment approach for paediatric anterior drooling. PubMed, Embase, and Web of Science were searched to identify relevant studies (until October 1, 2023) on submandibular or four-gland BoNT-A injections for the treatment of anterior drooling in children with neurodevelopmental disabilities. Similarities and differences in treatment, patient, outcome, and follow-up characteristics were assessed. Twenty-eight papers were identified; 7 reporting on submandibular injections and 21 on four-gland injections. No major differences in treatment procedures or timing of follow-up were found. However, patient characteristics were poorly reported, there was great variety in outcome measurement, and the assessment of side effects was not clearly described. Conclusion: This review highlights heterogeneity in outcome measures and patient population descriptors among studies on paediatric BoNT-A injections, limiting the ability to compare treatment effectiveness between submandibular and four-gland injections. These findings emphasize the need for more extensive and uniform reporting of patient characteristics and the implementation of a core outcome measurement set to allow for comparison of results between studies and facilitate the optimization of clinical practice guidelines. What is Known: • There is no international consensus on which salivary glands to initially inject with BoNT-A to treat paediatric drooling. What is New: • Concluding on the optimal initial BoNT-A treatment based on literature is currently infeasible. There is considerable heterogeneity in outcome measures used to quantify anterior drooling.and clinical characteristics of children treated with intraglandular BoNT-A are generally insufficiently reported. • Consensus-based sets of outcome measures and patient characteristics should be developed and implemented., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
13. Prioritizing parotid gland surgery: A call for the implementation of the MSRSGC classification.
- Author
-
Reerds STH, Honings J, van Engen ACH, Marres HAM, Takes RP, and van den Hoogen FJA
- Subjects
- Humans, Retrospective Studies, Salivary Glands pathology, Cytodiagnosis, Parotid Gland surgery, Parotid Gland pathology, Salivary Gland Neoplasms diagnosis
- Abstract
Background: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is developed to aid diagnosis and management of salivary gland tumors. This study evaluates the time-to-treatment initiation (TTI) for parotid gland tumors in the Netherlands and relates these to the MSRSGC classification. Subsequently, the use of the MSRSGC in the Netherlands is evaluated., Methods: Data regarding fine-needle aspiration cytology (FNAC) and histopathological resections of the parotid were gathered from the Dutch nationwide pathology data bank (PALGA). The TTI was calculated for each MSRSGC category and type of treating center. FNACs performed from 2018 to 2021 were gathered from PALGA to estimate how frequently the MSRSGC classification was applied., Results: Median TTI in days were 86 for nondiagnostic (MSRSGC I), 75 for nonneoplastic (MSRSGC II), 65 for atypia of unknown significance (AUS) (MSRSGC III), 89 for benign (MSRSGC IVa), 52 for salivary gland neoplasm of unknown malignant potential (SUMP) (MSRSGC IVb), 31 for suspected malignant (MSRSGC V), and 30 for malignant (MSRSGC VI) categories. Significant variation in the TTI between the types of treating centers was found for the nondiagnostic, nonneoplastic, AUS, SUMP, and suspected malignant categories. In the first 3 years after the introduction of the MSRSGC, the pathologist stated the MSRSGC classification in 6.4% of all reports., Conclusions: The median TTI for most categories is long, and there is significant interhospital variation in TTI. Preoperative risk stratification and treatment prioritization in parotid gland surgery in the Netherlands should be improved. The MSRSGC could contribute to this. Until 2021, the MSRSGS classification was implemented on a limited scale in the Netherlands., (© 2023 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Published
- 2023
- Full Text
- View/download PDF
14. Virtues in Competency-Based Assessment Frameworks: A Text Analysis.
- Author
-
Verstegen PMB, Kole JJJ, Groenewoud AS, and van den Hoogen FJA
- Subjects
- Humans, Virtues, Morals, Medicine, Surgeons
- Abstract
Introduction: Official documentation of specialty training provides comprehensive and elaborate criteria to assess residents. These criteria are commonly described in terms of competency roles and entrustable professional activities (EPA's), but they may also implicitly encompass virtues. Virtues are desirable personal qualities that enable a person, in this case, a medical specialist, to make and act on the right decisions. We articulate these virtues and explore the resulting implied ideal of a medical professional., Method: We applied a two-staged virtue ethical content analysis to analyze documents, specific to the Dutch training program of the Ear, Nose, and Throat (ENT) specialty. First, we identified explicit references to virtues. Next, we articulated implicit virtues through interpretation. The results were categorized into cardinal, intellectual, moral, and professional virtues., Results: Thirty virtues were identified in the ENT- training program. Amongst them, practical wisdom, temperance, and commitment. Furthermore, integrity, curiosity, flexibility, attentiveness, trustworthiness and calmness are often implicitly assumed. Notable findings are the emphasis on efficiency and effectiveness. Together, these virtues depict an ideal of a future medical specialist., Conclusion: Our findings suggest that competency-frameworks and EPA's implicitly appeal to virtues and articulate a specific ideal surgeon. Explicit attention for virtue development and discussion of the role and relevance of implied ideal professionals in terms of virtues could further improve specialty training., Competing Interests: Co-author F.J.A. van den Hoogen is also co-author of ENTER2. We have discussed this issue openly during team-meetings and together declared the importance of this critical analysis and the independence of researcher P.M.B. Verstegen, J.J. Kole, and A.S. Groenewoud. F.J.A. van den Hoogen actively supported and contributed to the critical analysis of the program and encouraged this research throughout., (Copyright: © 2023 The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
15. Outpatient parotidectomy with or without the use of a post-operative drain: A retrospective bi-institutional study.
- Author
-
Reerds STH, Hey SY, van den Hoogen FJA, Takes RP, Ganesh V, Marres HAM, Manickavasagam J, and Honings J
- Subjects
- Humans, Retrospective Studies, Outpatients, Postoperative Complications epidemiology, Parotid Gland surgery, Salivary Gland Diseases, Parotid Neoplasms surgery
- Abstract
Objective: Parotid surgery is historically performed as an inpatient procedure and suctions drains are predominantly used during surgery. Recent literature provides evidence that outpatient parotid surgery is safe and effective. Our study aims to describe the results of drainless outpatient parotidectomy and outpatient parotidectomy with drain placement and compare their outcomes., Design: Retrospective cohort study., Setting: Bi-institutional retrospective cohort study., Participants: Patients that underwent outpatient drain-less parotidectomy and patients that underwent outpatient parotidectomy with post-operative drain placement., Main Outcome Measures: Complication rates, unplanned post-operative visits, unplanned prolonged stay., Results: Three hundred eighty patients underwent outpatient parotidectomy with drain placement and 31 patients underwent outpatient drainless parotidectomy in two different hospitals. The incidence of haematoma (drain: 3.1% vs. drainless: 0%, p = 1), infection (drain: 14.3% vs. drainless: 13.8%, p = 1) and salivary fistula (drain: 5.6% vs. drainless: 3.4, p = 1) were comparable between both groups. Seroma or sialocele was more frequently seen in the drain-less group (27.6% vs. 6.2%, p < .001), but were all managed conservatively. Within 10 days after surgery, unplanned visits seemed more frequent in the drain group, although the difference was not statistically significant (14.9% vs. 3.4%, p = .16)., Conclusions: Outpatient parotid surgery with or without the use of a post-operative drain is safe, practical and feasible. Same-day discharge with and without drain placement yield comparable outcomes. However, the results need to be interpreted cautiously as this study was limited by a small cohort of parotidectomies without drain placement. Future studies should further compare both approaches., (© 2022 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
16. Postoperative Airway Management after Submandibular Duct Relocation in 96 Drooling Children and Adolescents.
- Author
-
Kok SE, Lemson J, and van den Hoogen FJA
- Abstract
The aim of this study was to evaluate our institutions airway management and complications after submandibular duct relocation (SMDR). We analysed a historic cohort of children and adolescents who were examined at the Multidisciplinary Saliva Control Centre between March 2005 and April 2016. Ninety-six patients underwent SMDR for excessive drooling. We studied details of the surgical procedure, postoperative swelling and other complications. Ninety-six patients, 62 males and 34 females, were treated consecutively by SMDR. Mean age at time of surgery was 14 years and 11 months. The ASA physical status was 2 in most patients. The majority of children were diagnosed with cerebral palsy (67.7%). Postoperative swelling of the floor of the mouth or tongue was reported in 31 patients (32.3%). The swelling was mild and transient in 22 patients (22.9%) but profound swelling was seen in nine patients (9.4%). In 4.2% of the patients the airway was compromised. In general, SMDR is a well-tolerated procedure, but we should be aware of swelling of the tongue and floor of the mouth. This may lead to a prolonged period of endotracheal intubation or a need for reintubation which can be challenging. After extensive intra-oral surgery such as SMDR we strongly recommend a extended perioperative intubation and extubation after the airway is checked and secure.
- Published
- 2023
- Full Text
- View/download PDF
17. Long-term effects of submandibular gland excision on drooling in children with neurodevelopmental disorders: A cross-sectional study.
- Author
-
Delsing CPA, Adriaansens C, van Hulst K, Erasmus CE, and van den Hoogen FJA
- Subjects
- Humans, Child, Adolescent, Cross-Sectional Studies, Submandibular Gland surgery, Salivary Glands, Treatment Outcome, Sialorrhea surgery, Sialorrhea complications, Neurodevelopmental Disorders, Cerebral Palsy complications
- Abstract
Aim: Submandibular gland excision (SMGE) is suitable for the management of drooling in patients with non-progressive neurodisabilities. We aimed to investigate the long-term effects of SMGE., Method: Patients who had SMGE between 2007 and 2018 were included. Main outcomes were a Visual Analogue Scale (VAS), Drooling Severity (DS), and Drooling Frequency (DF) collected at baseline, 8 weeks, 32 weeks and with a median of 313 weeks after SMGE (long-term). Secondary outcomes were satisfaction with the procedure, Drooling Quotient (DQ) and adverse events (AEs)., Results: We included thirty-five patients in the long-term analysis with a mean age of 14.5 years. A baseline VAS score of 80.4 was found, which improved on the long-term (mean difference -21.8, t(26) = 4.636, p < 0.0005)). DS and DF decreased significantly at the long-term compared to baseline (Z = -4.361, p < 0.0001 for DS, Z = -3.065, p = 0.002 for DF). Twenty-three out of 35 (66%) patients would recommend the procedure to peers., Interpretation: This study indicates a long-term stable effect on drooling after SMGE in patients with anterior drooling. Recurrence of drooling occurs due to unknown reasons, nevertheless most caregivers and/or patients are still satisfied and would recommend the procedure to others., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
18. Surgical management of deep lobe parotid tumours with and without involvement of the parapharyngeal space.
- Author
-
Reerds STH, Gerdsen M, van den Hoogen FJA, Takes RP, van den Broek GB, Vallen HGGJ, Marres HAM, and Honings J
- Subjects
- Humans, Parapharyngeal Space, Research Design, Retrospective Studies, Parotid Neoplasms diagnostic imaging, Parotid Neoplasms pathology, Parotid Neoplasms surgery
- Abstract
The diagnosis and treatment of deep lobe parotid tumours is challenging because of the complex surgical accessibility. There is a lack of studies describing the differences between deep lobe tumours that do and do not occupy the parapharyngeal space (PPS). Patients treated for deep lobe tumours occupying the PPS (PPS group) and not occupying the PPS (non-PPS group) were analysed retrospectively. A total of 227 patients were treated surgically for deep lobe parotid tumours between 1990 and 2019. Sixty patients (26.4%) presented with tumours that involved the PPS (PPS group), while 167 (73.6%) presented with tumours that did not occupy the PPS (non-PPS group). The majority of the PPS group tumours were removed using a transcervical or transcervical-transparotid approach. PPS group tumours were larger (P < 0.001), and tumour spill occurred more frequently in this group (benign tumours: P = 0.002; malignant tumours: P = 0.033). Complication rates did not differ between the PPS and non-PPS groups. A transcervical or transcervical-transparotid approach is the preferred method for the management of deep lobe parotid tumours that occupy the PPS in our practice. Tumour spill occurred more frequently in the PPS group, which is most probably due to the larger tumour size and more complex accessibility., (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
19. Validation of the Milan System for Reporting Salivary Gland Cytopathology and the diagnostic accuracy of FNA cytology for submandibular gland lesions.
- Author
-
Reerds STH, van Engen-van Grunsven ACH, van den Hoogen FJA, Takes RP, Marres HAM, and Honings J
- Subjects
- Biopsy, Fine-Needle methods, Humans, Retrospective Studies, Salivary Glands pathology, Salivary Gland Neoplasms diagnosis, Salivary Gland Neoplasms pathology, Salivary Gland Neoplasms surgery, Submandibular Gland pathology
- Abstract
Background: The Milan System for Salivary Gland Cytopathology (MSRSGC) is a categorical system for salivary gland fine-needle aspiration cytopathology (FNAC) developed to aid clinicians in the management of salivary gland lesions. This classification is widely studied and validated, especially in cohorts that consist of mostly parotid gland lesions. However, only sparse literature describes the use of this classification for submandibular gland lesions in particular., Methods: All patients in the Netherlands that underwent a submandibular gland resection between January 1, 2006, and January 1, 2017, with a FNAC before resection were identified with the use of the Dutch Pathology Registry database (PALGA). All FNAC results were retrospectively classified according to the MSRSGC. The risk of malignancy was calculated for all the MSRSGC categories. The sensitivity and specificity of the MSRSGC classification were calculated for submandibular gland FNAC., Results: A total of 837 patients who underwent 975 FNAC aspirates from the submandibular glands were included in the analysis. Risks of malignancy for each of the MSRSGC categories were 14.4% in nondiagnostic, 4.4% in nonneoplastic, 37.0% in atypia of unknown significance, 3.9% in benign neoplasms, 40.7% in salivary gland neoplasms of unknown malignant potential, 76.2% in suspected malignant, and 91.3% in malignant cytology results. The sensitivity for diagnosing malignant submandibular gland tumors was 71.6% and specificity was 98.4%., Conclusions: The results of the present study validate the use of this classification for submandibular gland lesions. Risks of malignancy vary according to the anatomical subsites of the salivary gland lesions., Lay Summary: The risks of malignancy of the various Milan System for Salivary Gland Cytopathology (MSRSGC) categories vary according to the anatomical subsite of the salivary gland lesion. The proposed management techniques of the MSRSGC are valid for use with submandibular gland lesions., (© 2021 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Published
- 2022
- Full Text
- View/download PDF
20. Flexible Endoscopic Biopsy: Identifying Factors to Increase Accuracy in Diagnosing Benign and Malignant Laryngopharyngeal Pathology.
- Author
-
Schimberg AS, Wellenstein DJ, Schutte HW, Honings J, van den Hoogen FJA, Marres HAM, Takes RP, and van den Broek GB
- Subjects
- Biopsy, Humans, Hypopharynx, Positron Emission Tomography Computed Tomography
- Abstract
Objectives: To assess the influence that several factors, such as the amount of obtained biopsies, difficult procedures, biopsy site and the experience of the attending physician, have on accuracy of flexible endoscopic biopsy (FEB)., Materials and Methods: 203 FEB procedures for benign or malignant laryngopharyngeal lesions were prospectively included. During the procedure, three representative biopsies (macroscopically containing vital tumor tissue and not only necrosis or healthy tissue) were obtained. The accuracy of each biopsy was separately analyzed. Difficulties during the procedures leading to failure of acquiring three representative biopsies were recorded and classified into tumor, patient and procedural factors. Histological results of FEB were defined correct when consistent with clinical context, additional biopsies or Positron emission tomography-computed tomography (PET-CT) revealed equivalent pathology, or the lesion was stable or resolved in >6 months follow-up., Results: The first representative biopsy yielded a correct diagnosis in 65% of the cases. After the second representative biopsy, 78% was correctly diagnosed. The contribution of the third and fourth representative biopsies to accuracy was 3%. The overall accuracy of FEB was 85%. Difficult procedures were more likely to result in misdiagnosis, whereas biopsy site or experience of the attending physician did not influence results., Conclusions: FEB was accurate in diagnosing laryngopharyngeal lesions when at least two representative biopsies were obtained. Accuracy of FEB could be further improved by limiting possible constraints during the procedures, for example by selecting, informing, and anesthetizing patients carefully., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
21. The medium to long-term effects of two-duct ligation for excessive drooling in neurodisabilities, a cross-sectional study.
- Author
-
Bekkers S, de Bock S, van Hulst K, Kok SE, Scheffer ART, and van den Hoogen FJA
- Subjects
- Adolescent, Cross-Sectional Studies, Humans, Neoplasm Recurrence, Local, Submandibular Gland, Treatment Outcome, Cerebral Palsy, Sialorrhea etiology, Sialorrhea surgery
- Abstract
Objectives: This study aims to evaluate the medium to long-term (1-12 years) effectiveness of two-duct ligation (2-DL) in patients with nonprogressive neurodisabilities., Methods: Main outcomes included a Visual Analogue Scale (VAS), Drooling Severity (DS) and Drooling Frequency (DF), collected at baseline, 32 weeks postintervention and 1-12 years postintervention. Secondary outcomes were adverse events (AEs), and satisfaction., Results: Forty-two patients were analyzed (mean age 17 years, mean baseline VAS 82). VAS decreased significantly from baseline to long-term (n = 30. Mean difference -36.5, CI -47.0 to -26.0, p ≤ 0.001; -26.1, CI -36.2 to -15.9, p ≤ 0.001). However, long-term VAS significantly increased compared to VAS at 32 weeks (+10.4, CI 1.0-19.8, p = 0.031). Out of 42 patients, 64% would recommend 2-DL to peers., Conclusion: There is a significant subjective 2-DL effect on drooling severity in the medium to long-term as reported by patients and caregivers, but there is also a certain degree of recurrence in this time span, and 33% of the patients required subsequent treatment. However, the majority of patients and/or caregivers would recommend 2-DL to peers., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
- Full Text
- View/download PDF
22. Surgery versus botulinum neurotoxin A to reduce drooling and improve daily life for children with neurodevelopmental disabilities: a randomized controlled trial.
- Author
-
Bekkers S, Pruijn IMJ, van der Burg JJW, van Hulst K, Kok SE, Delsing CP, Scheffer ART, and van den Hoogen FJA
- Subjects
- Adolescent, Child, Developmental Disabilities drug therapy, Developmental Disabilities surgery, Female, Humans, Male, Sialorrhea drug therapy, Sialorrhea surgery, Treatment Outcome, Young Adult, Botulinum Toxins, Type A therapeutic use, Developmental Disabilities therapy, Quality of Life, Salivary Ducts surgery, Sialorrhea therapy
- Abstract
Aim: To compare the effect of bilateral submandibular duct ligation and botulinum neurotoxin A (BoNT-A) on drooling severity and its impact on daily life and care in children and adolescents with moderate-to-severe drooling., Method: This was a randomized, interventional, controlled trial in which 53 children and adolescents (31 males, 22 females, mean age 11y, range 8-22y, SD 2y 10mo) with cerebral palsy (58.5%) or other non-progressive developmental disorders (41.5%) were randomized to BoNT-A (n=26) or bilateral submandibular duct ligation (n=27). A parent questionnaire on the severity of drooling in specific positions and daily activities and the impact of drooling on daily life and care was filled out at baseline and 8 and 32 weeks posttreatment., Results: Both BoNT-A and bilateral submandibular duct ligation had a positive effect on daily care, damage to electronic equipment and/or furniture, social interactions, and self-esteem. However, bilateral submandibular duct ligation had a significant greater and longer-lasting short- (8wks) and medium-term (32wks) effect on daily care, reducing damage to electronic devices, and improving social interactions and satisfaction with life in general., Interpretation: This randomized controlled trial confirms reduced drooling by both BoNT-A and bilateral submandibular duct ligation, but provides new evidence on improved well-being through a reduction in drooling. Even though there is a greater risk of complications and morbidity after bilateral submandibular duct ligation, compared to BoNT-A there was a significantly greater and longer-lasting positive effect on most outcomes. What this paper adds Bilateral botulinum neurotoxin A (BoNT-A) and submandibular duct ligation had a positive effect on the well-being of individuals with moderate-to-severe drooling. Bilateral submandibular duct ligation had a greater effect on the impact of drooling during daily care than BoNT-A. Bilateral submandibular duct ligation reduced damage to electronic devices and improved social interactions and satisfaction with life., (© 2021 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)
- Published
- 2021
- Full Text
- View/download PDF
23. Accuracy of parotid gland FNA cytology and reliability of the Milan System for Reporting Salivary Gland Cytopathology in clinical practice.
- Author
-
Reerds STH, Van Engen-Van Grunsven ACH, van den Hoogen FJA, Takes RP, Marres HAM, and Honings J
- Subjects
- Biopsy, Fine-Needle, Humans, Pathology methods, Reproducibility of Results, Retrospective Studies, Salivary Glands pathology, Parotid Gland pathology, Salivary Gland Neoplasms pathology
- Abstract
Background: Differentiating between malignant and benign salivary gland tumors with fine-needle aspiration cytology (FNAC) can be challenging. This study was aimed at testing the validity of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and at assessing possible differences in the sensitivity and specificity of parotid gland FNAC between dedicated head and neck (H&N) centers, subdivided into head and neck oncology centers (HNOCs) and head and neck oncology affiliated centers (HNOACs), and general hospitals (GHs)., Methods: The Dutch Pathology Registry (PALGA) database was searched for patients who had undergone a salivary gland resection between January 1, 2006, and January 1, 2017, and had a preoperative FNAC result. The FNAC reports were retrospectively assigned to MSRSGC categories. The risk of malignancy (ROM) was calculated for each category. The sensitivity and specificity for diagnosing malignancy were calculated and compared among HNOCs, HNOACs, and GHs., Results: In all, 12,898 FNAC aspirates were evaluated. The ROMs for each category were as follows: 12.5% in MSRSGC I, 10.3% in MSRSGC II, 29% in MSRSGC III, 2.3% in MSRSGC IVa, 28.6% in MSRSGC IVb, 83% in MSRSGC V, and 99.3% in MSRSGC VI. The sensitivity of FNAC was highest in HNOCs (88.1%), HNOACs scored lower (79.7%), and GHs had a sensitivity of 75.0%., Conclusions: The MSRSGC is a valid tool for reporting parotid gland FNAC; therefore, these results strongly advocate its use. On the basis of the higher sensitivity of FNAC in dedicated H&N centers, the authors recommend that GHs use the presented management strategies to help to minimize the chances of a preoperative misdiagnosis., (© 2021 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Published
- 2021
- Full Text
- View/download PDF
24. Myotonic dystrophy and recurrent pleomorphic adenomas: Case report and association hypothesis.
- Author
-
Pruijn IMJ, van Herpen CML, Pegge SAH, van Engen van Grunsven ACH, Ligtenberg MJ, and van den Hoogen FJA
- Subjects
- Adenoma, Pleomorphic diagnosis, Humans, Magnetic Resonance Imaging, Male, MicroRNAs, Middle Aged, Myotonin-Protein Kinase, Parotid Gland pathology, Salivary Gland Neoplasms diagnosis, Up-Regulation, beta Catenin, Adenoma, Pleomorphic complications, Myotonic Dystrophy complications, Salivary Gland Neoplasms complications
- Abstract
We report a case of a patient with concurrent myotonic dystrophy and recurrent pleomorphic adenoma and hypothesize the association between both diseases. A 58-year-old man with classic myotonic dystrophy type 1 was diagnosed with pleomorphic adenoma. Appropriate treatment was commenced. Massive recurrences occurred within 15, 28 and 22 months respectively, after repeated surgical removal. Three case reports on similar occurrences of synchronous myotonic dystrophy and pleomorphic adenoma are discussed and an association between both disease entities is hypothesized. A conceivable association between myotonic dystrophy and pleomorphic adenoma is hypothesized by upregulation of the Wnt/Beta-catenin signaling pathway, initiated by a decreased expression of microRNA, pleomorphic adenoma gene 1 induced Beta-catenin accumulations and alterations in tumor suppressor genes and oncogenes due to RNA processing defects induced by the expanded repeat in the DMPK gene., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
25. Impact of optimizing diagnostic workup and reducing the time to treatment in head and neck cancer.
- Author
-
Schutte HW, van den Broek GB, Steens SCA, Hermens RPMG, Honings J, Marres HAM, Merkx MAW, Weijs WLJ, Arens AIJ, van Engen-van Grunsven ACH, van Herpen CML, Kaanders JHAM, van den Hoogen FJA, and Takes RP
- Subjects
- Cohort Studies, Female, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms pathology, Humans, Male, Middle Aged, Patient Satisfaction, Progression-Free Survival, Proportional Hazards Models, Survival Rate, Chemotherapy, Adjuvant, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Time-to-Treatment
- Abstract
Background: Timely and efficient diagnostic workup of patients with head and neck cancer (HNC) is challenging. This observational study describes the implementation of an optimized multidisciplinary oncological diagnostic workup for patients with HNC and its impact on diagnostic and treatment intervals, survival, costs, and patient satisfaction., Methods: All patients with newly diagnosed HNC who underwent staging and treatment at the Radboud University Medical Center were included. Conventional workup (CW) in 2009 was compared with the fast-track, multidisciplinary, integrated care program, that is, optimized workup (OW), as implemented in 2014., Results: The study included 486 patients with HNC (218 with CW and 268 with OW). The time-to-treatment interval was significantly lower in the OW cohort than the CW cohort (21 vs 34 days; P < .0001). The 3-year overall survival rate was 12% higher after OW (72% in the CW cohort vs 84% in the OW cohort; P = .002). After correction for confounders, the 3-year risk of death remained significantly lower in the OW cohort (hazard ratio, 1.73; 95% confidence interval, 1.14-2.63; P = .010). Total diagnostic costs were comparable in the 2 cohorts. The general satisfaction score, as measured with the Consumer Quality Index for Oncological Care, was significantly better in a matched OW group than the CW group (9.1 vs 8.5; P = .007)., Conclusions: After the implementation of a fast-track, multidisciplinary, integrated care program, the time-to-treatment interval was significantly reduced. Overall survival and patient satisfaction increased significantly, whereas costs did not change. This demonstrates the impact and improved quality of care achieved by efficiently organizing the diagnostic phase of HNC management., (©2020 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Published
- 2020
- Full Text
- View/download PDF
26. Submandibular duct ligation after botulinum neurotoxin A treatment of drooling in children with cerebral palsy.
- Author
-
Bekkers S, Pruijn IMJ, Van Hulst K, Delsing CP, Erasmus CE, Scheffer ART, and Van Den Hoogen FJA
- Subjects
- Botulinum Toxins, Type A administration & dosage, Child, Female, Humans, Male, Neuromuscular Agents administration & dosage, Retrospective Studies, Botulinum Toxins, Type A pharmacology, Cerebral Palsy complications, Cerebral Palsy drug therapy, Cerebral Palsy surgery, Neuromuscular Agents pharmacology, Outcome Assessment, Health Care, Salivary Ducts surgery, Sialorrhea drug therapy, Sialorrhea etiology, Sialorrhea surgery, Submandibular Gland surgery
- Abstract
Aim: To assess: (1) the effect on drooling of bilateral submandibular duct ligation as surgical therapy after the administration of submandibular botulinum neurotoxin A (BoNT-A) for excessive drooling and (2) the predictive value of treatment success with BoNT-A on treatment success after bilateral submandibular duct ligation., Method: This was a within-participant retrospective observational study in which 29 children with severe drooling (15 males, 14 females) received BoNT-A treatment at a mean age of 9 years 6 months (SD 2y 5mo), followed by bilateral submandibular duct ligation at a mean age of 10 years 11 months (SD 2y 4mo). Fifteen children were diagnosed with cerebral palsy (CP), with 12 children classified in Gross Motor Function Classification System levels IV and V. The 14 children without CP had non-progressive developmental disorders. The primary drooling severity outcomes were the Visual Analogue Scale (VAS; subjective assessment) and drooling quotient (objective assessment). Measurements were taken before each intervention and again at 8 and 32 weeks., Results: The VAS was significantly lower after bilateral submandibular duct ligation at follow-up compared to BoNT-A treatment (mean difference -33, p≤0.001; 95% confidence interval [CI]=-43.3 to -22.9). The mean drooling quotient did not significantly differ between BoNT-A treatment and bilateral submandibular duct ligation at follow-up (3.3, p=0.457; 95% CI=-4.35 to 9.62) or between 8 and 32 weeks (4.7, p=0.188; 95% CI=-2.31 to 11.65)., Interpretation: BoNT-A treatment and bilateral submandibular duct ligation are both effective treatment modalities for drooling. At 32-week follow-up, subjective drooling severity after bilateral submandibular duct ligation was significantly lower compared to previous BoNT-A injections in participants. However, treatment success with BoNT-A is no precursor to achieving success with bilateral submandibular duct ligation., What This Paper Adds: Bilateral submandibular duct ligation is an effective therapy for drooling after treatment with botulinum neurotoxin A (BoNT-A). Treatment success with BoNT-A is not a predictor of successful therapy with bilateral submandibular duct ligation., (© 2020 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)
- Published
- 2020
- Full Text
- View/download PDF
27. Office-based CO 2 laser surgery for benign and premalignant laryngeal lesions.
- Author
-
Wellenstein DJ, Honings J, Schimberg AS, Schutte HW, Herruer JM, van den Hoogen FJA, Takes RP, and van den Broek GB
- Subjects
- Feasibility Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Ambulatory Surgical Procedures, Laryngeal Diseases surgery, Lasers, Gas therapeutic use, Precancerous Conditions surgery
- Abstract
Objective: Patients with laryngeal pathology are often treated with CO
2 laser surgery, usually in the operating room under general anesthesia. Although office-based laser surgery using several other laser types has been investigated, prospective studies on office-based CO2 laser surgery are scarce. Our goal was to investigate the feasibility of office-based CO2 laser surgery for benign and premalignant laryngeal pathology by analyzing completion rate, safety, effect on voice quality, and success rate (i.e., no residual or recurrent disease)., Methods: A prospective cohort study was performed of 30 consecutive procedures. Inclusion started in June 2016 and was completed in August 2018. Adult patients with clinically benign or premalignant laryngeal lesions who could not undergo transoral laser microsurgery in the operating room under general anesthesia were included. Reasons were either contraindications for general anesthesia, previously failed therapeutic laryngoscopy under general anesthesia, and preference of a procedure under topical anesthesia by the patient. The mean follow-up was 9 months., Results: Thirty procedures were performed in 27 patients (24 males) with an average age of 62 years. Twenty-nine (97%) procedures were fully completed without complications. The mean preoperative Voice Handicap Index (VHI) score (VHI 44) significantly decreased 2 months (VHI 28, P = 0.032) and 6 months (VHI 14, P < 0.001) after the procedure. Almost two-thirds of patients showed no residual or recurrent disease at their follow-up visits., Conclusion: Office-based CO2 laser surgery is a feasible and safe procedure that results in significant voice-quality improvement. Almost two-thirds of patients did not require further treatment., Level of Evidence: 2 Laryngoscope, 130:1503-1507, 2020., (© 2019 The Authors. The Laryngoscope published by Wiley Periodicals, Inc. on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)- Published
- 2020
- Full Text
- View/download PDF
28. An evaluation of predictors for success of two-duct ligation for drooling in neurodisabilities.
- Author
-
Bekkers S, van Hulst K, Erasmus CE, Delsing CP, Scheffer ART, and van den Hoogen FJA
- Subjects
- Adolescent, Child, Clinical Decision-Making, Female, Follow-Up Studies, Humans, Ligation, Male, Prognosis, Retrospective Studies, Severity of Illness Index, Sialorrhea physiopathology, Cerebral Palsy complications, Neurodevelopmental Disorders complications, Oral Surgical Procedures adverse effects, Oral Surgical Procedures methods, Outcome Assessment, Health Care, Sialorrhea etiology, Sialorrhea surgery, Submandibular Gland surgery
- Abstract
Background: Drooling is dependent on various clinical variables. However, while drooling proves refractory to two-duct ligation in 40% of patients, predictors for treatment success are sparse and to date there is little evidence why some respond well while others are non-responders. We aim to find predictors for treatment success and study the effectiveness of two-duct ligation for drooling in neurodisabilities., Methods: Fifty-four patients with moderate to severe drooling who had undergone two-duct ligation were screened for inclusion. Four patients were excluded due to missing or unreliable primary outcomes. The average age at the time of surgery was 12 years. Predictors were evaluated for treatment success which was defined as ≥ 50% visual analog scale for severity of drooling and/or drooling quotient reduction from baseline. Treatment effect was measured after 8 and 32 weeks compared to baseline., Results: Age (more mature), adequate posture (no anteflexion), and normal speech are predictors for treatment success. Compared to baseline, drooling quotient was significantly lower at 8 (difference 18.6%, 95% confidence interval 12.3-24.9%) and 32 weeks (difference 10.1%, 95% confidence interval 3.9-16.4%). Compared to baseline, visual analog scale was significantly lower at 8 (difference 45.0, 95% confidence interval 37.0-52.9) and 32 weeks (difference 32.9, 95% confidence interval 25.0-40.7)., Conclusions: Age, adequate posture, and a normal speech are predictors for treatment success, are easily determined pre-operatively, and help the clinician providing patient-specific probability of treatment success. There is a significant subjective and objective decrease of drooling after two-duct ligation.
- Published
- 2020
- Full Text
- View/download PDF
29. Impact of Time to Diagnosis and Treatment in Head and Neck Cancer: A Systematic Review.
- Author
-
Schutte HW, Heutink F, Wellenstein DJ, van den Broek GB, van den Hoogen FJA, Marres HAM, van Herpen CML, Kaanders JHAM, Merkx TMAW, and Takes RP
- Subjects
- Humans, Treatment Outcome, Laryngeal Neoplasms diagnosis, Laryngeal Neoplasms therapy, Mouth Neoplasms diagnosis, Mouth Neoplasms therapy, Pharyngeal Neoplasms diagnosis, Pharyngeal Neoplasms therapy, Time-to-Treatment
- Abstract
Objective: An increased interval between symptomatic disease and treatment may negatively influence oncologic and/or functional outcomes in head and neck cancer (HNC). This systematic review aims to provide insight into the effects of time to treatment intervals on oncologic and functional outcomes in oral cavity, pharyngeal, and laryngeal cancer., Data Sources: PubMed, EMBASE, and Cochrane library were searched., Review Methods: All studies on delay or time to diagnosis or treatment in oral, pharyngeal, and laryngeal cancer were included. Quality assessment was performed with an adjusted version of the Newcastle-Ottawa scale. Outcomes of interest were tumor volume, stage, recurrence, survival, patient-reported outcome measures (PROMs), toxicity, and functionality after treatment., Results: A total of 51 studies were included. Current literature on the influence of delay in HNC is inconsistent but indicates higher stage and worse survival with longer delay. The effects on PROMs, toxicity, and functional outcome after treatment have not been investigated. The inconsistencies in outcomes were most likely caused by factors such as heterogeneity in study design, differences in the definitions of delay, bias of results, and incomplete adjustment for confounding factors in the included studies., Conclusion: Irrespective of the level of evidence, the unfavorable effects of delay on oncologic, functional, and psychosocial outcomes are undisputed. Timely treatment while maintaining high-quality diagnostic procedures and decision making reflects good clinical practice in our opinion. This review will pose practical and logistic challenges that will have to be overcome.
- Published
- 2020
- Full Text
- View/download PDF
30. Office-based vs. operating room-performed laryngopharyngeal surgery: a review of cost differences.
- Author
-
Schimberg AS, Wellenstein DJ, van den Broek EM, Honings J, van den Hoogen FJA, Marres HAM, Takes RP, and van den Broek GB
- Subjects
- Anesthesia, General economics, Anesthesia, Local economics, Humans, Netherlands, Otorhinolaryngologic Surgical Procedures methods, United States, Ambulatory Surgical Procedures economics, Health Care Costs statistics & numerical data, Hospitalization economics, Larynx surgery, Operating Rooms economics, Otorhinolaryngologic Surgical Procedures economics, Pharynx surgery
- Abstract
Purpose: Office-based transnasal flexible endoscopic surgery under topical anesthesia has recently been developed as an alternative for transoral laryngopharyngeal surgery under general anesthesia. The aim of this study was to evaluate differences in health care costs between the two surgical settings., Methods: PubMed, EMBASE and Cochrane Library were searched for studies reporting on costs of laryngopharyngeal procedures that could either be performed in the office or operating room (i.e., laser surgery, biopsies, vocal fold injection, or hypopharyngeal or esophageal dilation). Quality assessment of the included references was performed., Results: Of 2953 identified studies, 13 were included. Quality assessment revealed that methodology differed significantly among the included studies. All studies reported lower costs for procedures performed in the office compared to those performed in the operating room. The variation within reported hospital and physician charges was substantial., Conclusion: Office-based laryngopharyngeal procedures under topical anesthesia result in lower costs compared to similar procedures performed under general anesthesia.
- Published
- 2019
- Full Text
- View/download PDF
31. Submandibular gland botulinum neurotoxin A injection for predicting the outcome of submandibular duct relocation in drooling: a retrospective cohort study.
- Author
-
Kok SE, van Valenberg HFJP, van Hulst K, Jongerius P, Erasmus CE, and van den Hoogen FJA
- Subjects
- Adolescent, Adult, Child, Female, Humans, Injections, Male, Prognosis, Retrospective Studies, Submandibular Gland drug effects, Submandibular Gland surgery, Treatment Outcome, Young Adult, Acetylcholine Release Inhibitors administration & dosage, Botulinum Toxins, Type A administration & dosage, Sialorrhea complications, Sialorrhea diagnosis, Sialorrhea drug therapy, Sialorrhea surgery
- Abstract
Aim: This study evaluated whether the effect of submandibular gland botulinum neurotoxin A (BoNT-A) injection can predict the outcome of submandibular duct relocation with sublingual gland excision (SMDR) in children with drooling. Furthermore, we compared the effectiveness of both procedures., Method: A retrospective cohort study was performed in 42 children and adolescents (25 males, 17 females; mean [SD] age at BoNT-A injection 11y [4], range 4-20y; mean [SD] age at SMDR 15y [4], range 7-23y) with cerebral palsy or another non-progressive developmental disability who had undergone both BoNT-A injection and SMDR for drooling. Main outcomes were the drooling quotient and the visual analogue scale (VAS) on drooling severity at 8 weeks and 32 weeks follow-up., Results: Failure or success of previous BoNT-A injections had no influence on success of consecutive SMDR. Relative change in main outcomes showed no significant relation between BoNT-A injection and SMDR for any follow-up measurement. After 8 weeks, SMDR was more successful than BoNT-A injection in diminishing VAS (VAS 80.0% vs 54.3%; drooling quotient 56.2% vs 51.0%). After 32 weeks, both drooling quotient (64.3% vs 29.5%) and VAS (75.7% vs 37.1%) showed significantly higher proportions of success for SMDR., Interpretation: The effect of submandibular BoNT-A injection does not predict subsequent SMDR success in drooling. Furthermore, SMDR has a larger and longer-lasting positive effect on drooling than BoNT-A injections., What This Paper Adds: Submandibular botulinum neurotoxin A (BoNT-A) injection effect does not predict submandibular duct relocation with sublingual gland excision outcome. Submandibular duct relocation is more effective and more permanent than BoNT-A injection., (© 2019 Mac Keith Press.)
- Published
- 2019
- Full Text
- View/download PDF
32. Topical Anesthesia for Endoscopic Office-based Procedures of the Upper Aerodigestive Tract.
- Author
-
Wellenstein DJ, van der Wal RAB, Schutte HW, Honings J, van den Hoogen FJA, Marres HAM, Takes RP, and van den Broek GB
- Subjects
- Administration, Topical, Head and Neck Neoplasms surgery, Humans, Larynx, Nasal Cavity, Pharynx, Anesthesia, Local, Anesthetics administration & dosage, Laryngoscopy
- Abstract
Objective: Over the last two decades, an increase in office-based procedures under topical anesthesia in laryngology and head and neck oncology has occurred. Adequate anesthesia in the nasal cavity, pharynx, and larynx is essential for successful performance of these procedures. Our goal is to provide an objective summary on the available local anesthetics, methods of application, local secondary effects, efficacy, and complications., Material and Methods: A descriptive review of literature on topical anesthesia for office-based procedures in laryngology and head and neck oncology was performed., Results: Lidocaine is the most applied and investigated topical anesthetic. Topical anesthesia results in decreased sensory function without impairing motor function of the pharynx and larynx. For the nasal cavity, cotton pledgets soaked in anesthetic spray and decongestant, or anesthetic gel, are effective. For the pharynx, anesthetic spray is the most frequently used and effective method. For the larynx, applying local anesthesia through a catheter through the working channel of the endoscope or anesthetic injection through the cricothyroid membrane is effective. Studies comparing the most effective application methods for each anatomical site are lacking. Complications of topical lidocaine administration are rare., Conclusions: By properly applying topical anesthesia to the upper aerodigestive tract, several surgical procedures in laryngology and head and neck oncology can be performed in the outpatient clinic under topical anesthesia instead of the operating room under general anesthesia. Lidocaine is the most investigated anesthetic, with adequate efficacy and few complications. Studies that determine the most effective application methods are still wanting., (Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
33. Unsuccessful submandibular duct surgery for anterior drooling: Surgical failure or parotid gland salivation?
- Author
-
Delsing CPA, Bekkers S, van Hulst K, Erasmus CE, and van den Hoogen FJA
- Subjects
- Adolescent, Cerebral Palsy complications, Child, Cohort Studies, Female, Humans, Ligation, Male, Recurrence, Salivation, Sialorrhea etiology, Treatment Outcome, Young Adult, Parotid Gland surgery, Salivary Ducts surgery, Sialorrhea surgery, Submandibular Gland surgery
- Abstract
Objectives: To evaluate if drooling recurrence after surgery of the submandibular ducts is due to surgical failure or other variables., Methods: Historic cohort with prospective collected data of all patients with severe drooling who underwent unsuccessful submandibular duct surgery with subsequent re-intervention between 2003 and 2018. A reference cohort was used for comparison of clinical variables., Results: Six males and 4 females were included (cerebral palsy n = 8, neurodevelopmental disorders n = 2). All patients underwent submandibular gland surgery as a primary intervention (duct ligation n = 8, submandibular duct relocation n = 2) followed by re-intervention (submandibular gland excision n = 7, parotid duct ligation n = 3). One patient underwent tertiary surgery (parotid duct ligation after re-intervention by submandibular gland excision). Three patients were successful after re-intervention. No difference was found between both re-intervention techniques. There was significantly more severe dental malocclusion (50% vs. 21%, P value = 0.047) and severe speech disorders (80% vs. 42%, P value = 0.042) in the current cohort when compared to the reference cohort., Conclusion: Recurrence of drooling surgery is most likely not caused by surgical failure of the primary intervention, because re-intervention (submandibular gland excision) did not lead to more success. Dysarthria and dental malocclusion might negatively influence treatment outcome., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
34. Cost analysis of office-based transnasal esophagoscopy.
- Author
-
Wellenstein DJ, Honings J, Schutte HW, Herruer JM, van den Hoogen FJA, Marres HAM, Takes RP, and van den Broek GB
- Subjects
- Adult, Aged, Aged, 80 and over, Ambulatory Care methods, Cost Savings statistics & numerical data, Deglutition Disorders etiology, Esophagoscopy economics, Feasibility Studies, Female, Humans, Male, Middle Aged, Netherlands, Nose, Prospective Studies, Ambulatory Care economics, Cost-Benefit Analysis, Deglutition Disorders diagnostic imaging, Esophagoscopy methods, Health Care Costs statistics & numerical data, Hypopharyngeal Neoplasms diagnostic imaging, Pharyngeal Diseases diagnostic imaging
- Abstract
Purpose: Although office-based transnasal esophagoscopy has been investigated extensively, a cost analysis is still lacking. We performed a cost analysis combined with feasibility study for two diagnostic processes: patients with globus pharyngeus and/or dysphagia, and hypopharyngeal carcinoma., Methods: Prospective cohort study., Results: Forty-one procedures were performed, of which 35 were fully completed. The procedure was well tolerated with mild complaints such as nasal or pharyngeal pain and burping. Four complications occurred: two minor epistaxis and two vasovagal reactions. In patients with globus pharyngeus and/or dysphagia, transnasal esophagoscopy resulted in a cost saving of €94.43 (p 0.026) per procedure, compared to our regular diagnostic process. In patients with suspicion of hypopharyngeal carcinoma, cost savings were €831.41 (p 0.000) per case., Conclusions: Cost analysis showed that office-based transnasal esophagoscopy can provide significant cost savings for the current standard of care. Furthermore, this procedure resulted in good patient acceptability and few complications.
- Published
- 2019
- Full Text
- View/download PDF
35. Randomized controlled trial comparing botulinum vs surgery for drooling in neurodisabilities.
- Author
-
Bekkers S, Delsing CP, Kok SE, van Hulst K, Erasmus CE, Scheffer ART, and van den Hoogen FJA
- Subjects
- Adolescent, Cerebral Palsy complications, Child, Female, Humans, Ligation, Male, Neurodevelopmental Disorders complications, Sialorrhea etiology, Botulinum Toxins, Type A therapeutic use, Neuromuscular Agents therapeutic use, Salivary Ducts surgery, Sialorrhea therapy, Submandibular Gland surgery
- Abstract
Objective: To compare the effect of submandibular duct ligation (2-DL) and submandibular botulinum neurotoxin type A (BoNT-A) for drooling in children and adolescents with neurodevelopmental disabilities., Methods: A randomized, interventional, controlled, and partly single-blinded study was performed in which submandibular BoNT-A was compared with 2-DL to treat excessive drooling. Main outcomes included a Visual Analog Scale (VAS), drooling quotient (DQ), drooling severity (DS) scale and drooling frequency (DF) scale. Each was obtained at baseline, and 8 and 32 weeks post treatment., Results: Fifty-seven patients (mean age: 11 years, mean baseline VAS score 7.9, mean baseline DQ 27.3%) were randomized to the 2-DL or BoNT-A group. Four patients were excluded from analyses, leaving 53 patients for intention-to-treat analyses. Response to treatment, defined as a ≥50% reduction in DQ or VAS score, was higher for 2-DL after 32 weeks (63.0% vs 26.9%, p = 0.008). Both VAS score (24.5, p < 0.001) and DQ (-9.3%, p = 0.022) were significantly lower at follow-up after 2-DL vs BoNT-A. The total number of adverse events ( p = 0.088, 40.7% vs 19.2%) and postoperative complaints was higher ( p < 0.001, mean 9.6 vs 3.6 days) for 2-DL than for BoNT-A., Conclusion: The 2-DL procedure is a more effective treatment for drooling than botulinum toxin, but carries a slightly greater risk of complications and morbidity., Trialregisternl Identifier: NTR3537., Classification of Evidence: This study provides Class III evidence that for children and adolescents with neurodevelopmental disabilities and severe drooling, 2-DL compared to a one-time intraglandular BoNT-A injection is more effective at reducing drooling at 32 weeks., (© 2019 American Academy of Neurology.)
- Published
- 2019
- Full Text
- View/download PDF
36. Effectiveness of submandibular duct relocation in 91 children with excessive drooling: A prospective cohort study.
- Author
-
Kok SE, Erasmus CE, Scheffer ART, van Hulst K, Rovers MM, and van den Hoogen FJA
- Subjects
- Adolescent, Adult, Child, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Treatment Outcome, Young Adult, Otorhinolaryngologic Surgical Procedures methods, Salivary Ducts surgery, Sialorrhea surgery, Submandibular Gland surgery
- Abstract
Objective: To evaluate the effectiveness of submandibular duct relocation (SMDR) in drooling children with neurological disorders., Design: Prospective cohort study., Setting: Academic Outpatient Saliva Control Clinic., Participants: Ninety-one children suffering from moderate to severe drooling., Main Outcome Measures: Direct observational drooling quotient (DQ; 0-100) and caretaker Visual Analogue Scale (VAS; 0-100). Secondary outcome measures were drooling severity (DS) and frequency rating scales., Results: The DQ at baseline, 8 and 32 weeks postoperatively was 26.4, 12.3 and 10.8, respectively. VAS score decreased from 80.1 at baseline to 28.3 and 37.0 at 8 and 32 weeks after surgery. Median DS at baseline, 8 and 32 weeks was 5, 3 and 4, whereas the drooling frequency median scores were 4, 2 and 2, respectively. Five children required prolonged intubation due to transient floor of the mouth swelling, two of whom developed a ventilator-associated pneumonia. Another child developed atelectasis with postoperative pneumonia. Two more children needed tube feeding because of postoperative eating difficulties for 3 days or suprapubic catheterisation for urinary retention. Children aged 12 years or older (OR = 3.41; P = 0.03) and those with adequate stability and position of the head (OR = 2.84; P = 0.09) appeared to benefit most from treatment., Conclusions: Submandibular duct relocation combined with excision of the sublingual glands appears to be relatively safe and effective in diminishing visible drooling in children with neurological disorders, particularly in children aged 12 years and older and those without a forward head posture., (© 2018 John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
37. Digital Video Laryngoscopy and Flexible Endoscopic Biopsies as an Alternative Diagnostic Workup in Laryngopharyngeal Cancer: A Prospective Clinical Study.
- Author
-
Schutte HW, Takes RP, Slootweg PJ, Arts MJPA, Honings J, van den Hoogen FJA, Marres HAM, and van den Broek GB
- Subjects
- Aged, Anesthesia, Local, Feasibility Studies, Female, Humans, Image-Guided Biopsy, Laryngoscopes, Male, Predictive Value of Tests, Prospective Studies, Ambulatory Surgical Procedures, Carcinoma diagnosis, Laryngeal Neoplasms diagnosis, Laryngoscopy, Pharyngeal Neoplasms diagnosis
- Abstract
Objectives: An office-based workup strategy for patients with laryngopharyngeal lesions suspicious for carcinoma is analyzed. The feasibility of office-based transnasal flexible endoscopic biopsies under local anesthesia and the impact on the diagnostic workup are evaluated., Methods: This study is a prospective analysis of patients with laryngeal, oropharyngeal, and hypopharyngeal lesions suspicious for carcinoma. One hundred eighty-eight participants were divided into 2 groups. The first group underwent an office-based biopsy procedure under local anesthesia using a flexible digital video laryngoscope with instrument channel (n = 53), and the second group underwent a biopsy procedure under general anesthesia using rigid laryngopharyngoscopy (n = 135)., Results: Office-based flexible endoscopic biopsies were tolerated well, and there were no complications. These biopsies were 92.5% successful in acquiring a definitive diagnosis. Costs were reduced. Diagnostic workup time and time until start of therapy were reduced to 2 days and 27 days, respectively., Conclusion: Office-based biopsy under local anesthesia using flexible digital video laryngoscopy is safe, cost-effective, and successful in providing a histopathological diagnosis. It reduces the diagnostic workup time significantly in patients with laryngeal, oropharyngeal, and hypopharyngeal cancer, while also reducing the necessity to subsequently perform a rigid laryngopharyngoscopy under general anesthesia.
- Published
- 2018
- Full Text
- View/download PDF
38. Development of the Drooling Infants and Preschoolers Scale (DRIPS) and reference charts for monitoring saliva control in children aged 0-4 years.
- Author
-
van Hulst K, van den Engel-Hoek L, Geurts ACH, Jongerius PH, van der Burg JJW, Feuth T, van den Hoogen FJA, and Erasmus CE
- Subjects
- Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Netherlands epidemiology, Reference Standards, Saliva metabolism, Saliva physiology, Sialorrhea diagnosis, Sialorrhea epidemiology, Surveys and Questionnaires standards
- Abstract
Objectives: To develop and validate a parent questionnaire to quantify drooling severity and frequency in young children (the Drooling Infants and Preschoolers Scale - the DRIPS). To investigate development of saliva control in typically developing young children in the age of 0-4 years. To construct sex-specific reference charts presenting percentile curves for drooling plotted for age to monitor the development of saliva control in infancy and preschool age., Study Design: The DRIPS was developed consisting of 20 items to identify severity and frequency of drooling during meaningful daily activities. Factor analysis was performed to test construct validity. A piecewise logistic regression was followed by a piecewise linear regression to construct sex-specific reference charts., Results: We obtained 652 completed questionnaires from parents of typically developing children. The factor analysis revealed four discriminating components: drooling during Activities, Feeding, Non nutritive sucking, and Sleep. To illustrate the development of saliva control, eight sex-specific reference curves were constructed to plot the scores of the DRIPS by age group, at the 15th, 50th, 85th and 97th percentile. About 3-15% of the preschoolers in our cohort did not acquire full saliva control at the age of 4 years., Conclusions: With the DRIPS it is possible to validly compare and visualize the development of saliva control in an individual infant or preschooler and allow clinicians to timely initiate individually targeted interventions if children outperform., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
39. Safety of flexible endoscopic biopsy of the pharynx and larynx under topical anesthesia.
- Author
-
Wellenstein DJ, de Witt JK, Schutte HW, Honings J, van den Hoogen FJA, Marres HAM, Takes RP, and van den Broek GB
- Subjects
- Aged, Ambulatory Care methods, Anesthetics, Local administration & dosage, Female, Humans, Male, Middle Aged, Retrospective Studies, Anesthesia, Local methods, Biopsy methods, Laryngeal Diseases diagnosis, Laryngoscopy methods, Larynx pathology, Pharyngeal Diseases diagnosis, Pharynx pathology
- Abstract
Recent advancements in transnasal endoscopy enable a shift in diagnostic workup of lesions in the pharynx and larynx, from an examination with biopsy under general anesthesia to an office-based examination with flexible endoscopic biopsy under topical anesthesia. Procedural complications were evaluated to assess the safety of office-based flexible endoscopic biopsy in patients with benign and malignant laryngopharyngeal lesions. Patients who underwent flexible endoscopic biopsy from 2012 to 2016 were evaluated retrospectively. Complications were classified using the Clavien-Dindo classification of surgical complications. A total of 201 flexible endoscopic biopsies were performed in 187 patients. Two Clavien-Dindo grade I (laryngospasm and anterior epistaxis), one grade II (laryngeal bleeding), and one grade IIIb (laryngeal edema) complication were observed. The first complication was self-limiting and the other three required an intervention. All patients fully recovered without sequelae. Flexible endoscopic biopsy appears to be a safe office-based procedure for the diagnosis of benign and malignant laryngopharyngeal lesions.
- Published
- 2017
- Full Text
- View/download PDF
40. Combination of docetaxel, trastuzumab and pertuzumab or treatment with trastuzumab-emtansine for metastatic salivary duct carcinoma.
- Author
-
van Boxtel W, Boon E, Weijs WLJ, van den Hoogen FJA, Flucke UE, and van Herpen CML
- Subjects
- Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Docetaxel, Receptor, ErbB-2, Salivary Ducts, Taxoids, Maytansine, Trastuzumab
- Published
- 2017
- Full Text
- View/download PDF
41. The efficacy of hyperbaric oxygen therapy related to the clinical stage of osteoradionecrosis of the mandible.
- Author
-
Dieleman FJ, Phan TTT, van den Hoogen FJA, Kaanders JHAM, and Merkx MAW
- Subjects
- Adult, Aged, Combined Modality Therapy, Female, Humans, Male, Mandibular Diseases pathology, Mandibular Diseases surgery, Middle Aged, Osteoradionecrosis pathology, Osteoradionecrosis surgery, Radiotherapy Dosage, Treatment Outcome, Hyperbaric Oxygenation, Mandibular Diseases therapy, Osteoradionecrosis therapy, Tongue Neoplasms radiotherapy
- Abstract
This study aimed to evaluate the success of hyperbaric oxygen therapy (HBOT) and surgery in the treatment of mandibular osteoradionecrosis (ORN) in relation to the extent of the ORN. Twenty-seven patients with ORN were identified from a total of 509 patients with a history of primary oral or base of the tongue cancer; these patients had been treated with radiation therapy with curative intent between 1992 and 2006, with a radiation dose to the mandible of ≥50Gy. The ORN was staged according to the classification of Notani et al. The time from completion of radiation therapy to the development of ORN varied (median 3 years). Forty HBOT sessions were offered. After HBOT alone, 3 of 11 stage I lesions, 0 of 8 stage II lesions, and 0 of 8 stage III lesions had healed (P=0.0018). An absolute incidence of 5.3% ORN was found in this population. Of all sites irradiated in this study, the floor of the mouth was most associated with ORN (8.6%), whereas the cheek was least associated (0%). Based on the results of this study, HBOT can be recommended for stage I and II ORN and for selected cases of stage III ORN., (Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.