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2. Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients

Author

Ranchor, Adelta V., Gomes Neto, Antonio W., Diepstra, Arjan, Hepkema, Bouke G., Tji Gan, C., Doorenbos, Caecilia S.E., te Velde-Keyzer, Charlotte A., van Leer-Buter, Coretta, Touw, Daan J., Hak, Eelko, Verschuuren, Erik A.M., Bodewes, Frank A.J.A., Klont, Frank, Dijkstra, Gerard, Nieuwenhuis-Moeke, Gertrude J., Blokzijl, Hans, Leuvenink, Henri G.D., Niesters, Hubert G.M., Cas Swarte, J., Sanders, Jan Stephan F., Damman, Kevin, Joost van Pelt, L., van Londen, Marco, de Boer, Marieke T., Siebelink, Marion J., van den Heuvel, Marius C., Vos, Michel J., Erasmus, Michiel E., Douwes, Rianne M., Slart, Riemer J.H.J.A., Weersma, Rinse K., Pol, Robert A., Porte, Robert J., de Meijer, Vincent E., Lexmond, Willem S., Kremer, Daan, Knobbe, Tim J., Vinke, Joanna Sophia J., Groothof, Dion, Post, Adrian, Annema, Coby, Abrahams, Alferso C., van Jaarsveld, Brigit C., de Borst, Martin H., Berger, Stefan P., Bakker, Stephan J.L., and Eisenga, Michele F.

Published
2024
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4. Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan

Author

Lluís, Núria, Onoe, Shunsuke, Serradilla-Martín, Mario, Achalandabaso, Mar, Mizuno, Takashi, Jehaes, François, Dasari, Bobby V.M., Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J.H., Amaral, María J., Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, López-López, Víctor, Detry, Olivier, Pozo, Carlos Domingo-del, Machairas, Nikolaos, Pekli, Damján, Alcázar-López, Cándido F., Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Díez-Caballero, Alberto, Francart, David, Noel, Colin B., Sousa-Silva, Donzília, Toledo-Martínez, Enrique, Tzimas, George N., Yaqub, Sheraz, Yamaguchi, Junpei, Dokmak, Safi, Prieto-Calvo, Mikel, D'Souza, Melroy A., Spiers, Harry V.M., van den Heuvel, Marius C., Charco, Ramón, Lesurtel, Mickaël, Ebata, Tomoki, and Ramia, José M.

Published
2024
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5. Prolonged hypothermic machine perfusion enables daytime liver transplantation – an IDEAL stage 2 prospective clinical trial

Author

de Meijer, Vincent E., Brüggenwirth, Isabel M.A., Lantinga, Veerle A., Moers, Cyril, Monbaliu, Diethard, Hofker, Sijbrand H., Bottema, Jan, Franke, Hildegaard S., de Boer, Marieke T., van den Boom, Anne Loes, Buis, Carlijn I., Fouraschen, Suomi M.G., Hoogwater, Frederik J.H., Klaase, Joost M., de Kleine, Ruben H.J., Meerdink, Mark, Nijkamp, Maarten W., Porte, Robert J., Rayar, A. Michel, van den Berg, Aad P., Blokzijl, Hans, Cuperus, Frans J.C., van der Heide, Frans, van Vilsteren, Frederike G.I., Abbasova, Ilhama F., Fernhout, Meine H., Meyer, Peter, Muskiet, Ernesto R.R., Reyntjens, Koen M.E.M., Vos, Jaap J., Zeillemaker, Miriam, Haring, Martijn P.D., Lascaris, Bianca, Pamplona, Carol C., Thorne, Adam M., Veenma, Vivianne, van Leeuwen, Otto B., Bodewes, Silke B., Lisman, Ton, Adelmeijer, Jelle, Wiersema-Buist, Janneke, van den Heuvel, Marius, and de Kleine, Ruben H.

Published
2024
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6. Central Body Fat Distribution and Kidney Function after Living Kidney Donation

Author

Westenberg, Lisa B., Pol, Robert A., van der Weijden, Jessica, de Borst, Martin H., Bakker, Stephan J.L., van Londen, Marco, Annema, Coby, Berger, Stefan P., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Douwes, Rianne M., Doorenbos, Caecilia S.E., Eisenga, Michele F., Erasmus, Michiel E., Gan, C. Tji, Gomes Neto, Antonio W., Hak, Eelko, Hepkema, Bouke G., van den Heuvel, Marius C., Klont, Frank, Knobbe, Tim J., Kremer, Daan, van Leer-Buter, Coretta, Leuvenink, Henri G.D., van Londen, Marco, Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., Nieuwenhuis-Moeke, Gertrude J., Joost van Pelt, L., Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Swarte, J. Cas, Touw, Daan J., te Velde-Keyzer, Charlotte A., Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., and Bakker, Stephan J.L.

Published
2024
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7. Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

Author

Annema, Coby, Blokzijl, Hans, Bodewes, Frank AJA., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia SE., Eisenga, Michele F., Erasmus, Michiel E., Gan, C Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri GD., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert GM., Joost van Pelt, L., Pol, Robert A., Porte, Robert J., Ranchor, Adelita V., Stephan F Sanders, Jan, Siebelink, Marion J., Slart, Riemer JHJA., Touw, Daan J., te Velde-Keyzer, Charlotte A., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik AM., Vos, Michel J., Weersma, Rinse K., Knobbe, Tim J., Lenis, Gijs M.M., van der Vossen, Dirk A.J., Wentink, Jory, Kremer, Daan, Quint, Evelien E., Gomes Neto, Antonio W., Dullaart, Robin P.F., Berger, Stefan P., Franssen, Casper F.M., Bakker, Stephan.J.L., and Post, Adrian

Published
2024
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8. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study

Author

Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., and Bakker, Stephan J.L.

Published
2023
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9. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

Author

Alseidi, Adnan, Aquilano, Constanza, Arola, Johanna, Bianchi, Denise, Brown, Rachel, Campani, Daniela, ChinAleong, Joanne, Cros, Jerome, Dimitrova, Lyubomira, Doglioni, Claudio, Dokmak, Safi, Dorer, Russell, Doukas, Michael, Fabre, Jean Michel, Ferrari, Giovanni, Grinevich, Viacheslay, Gobbo, Stefano, Hackert, Thilo, van den Heuvel, Marius, Huijsentruijt, Clement, Iglesias, Mar, Jansen, Casper, Khatkov, Igor, Kooby, David, Lena, Marco, Luchini, Claudio, Menon, Krishna, Michenet, Patrick, Molenaar, Quintus, Nedkova, Anna, Pietrabissa, Andrea, Raicu, Mihaela, Rajak, Rushda, Rankovic, Branislava, Rendek, Aniko, Riviere, Benjamin, Cunha, Antonio Sa, Marc, Olivier Saint, Velazquez, Patricia Sanchez, Santini, Donatella, Scarpa, Aldo, Sebagh, Mylene, Sears, Donald, Shah, Mihir, Soonawalla, Zahir, Spaggiari, Paola, Tharun, Lars, Tholfsen, Tore, Tomazic, Ales, Vanoli, Alessandro, Verbeke, Caroline, Verheij, Joanne, Von Winterfeld, Moritz, de Wilde, Roeland, Yip, Vincent, Zen, Yoh, Korrel, Maarten, Jones, Leia R., van Hilst, Jony, Balzano, Gianpaolo, Björnsson, Bergthor, Boggi, Ugo, Bratlie, Svein Olav, Busch, Olivier R., Butturini, Giovanni, Capretti, Giovanni, Casadei, Riccardo, Edwin, Bjørn, Emmen, Anouk M.L.H., Esposito, Alessandro, Falconi, Massimo, Groot Koerkamp, Bas, Keck, Tobias, de Kleine, Ruben H.J., Kleive, Dyre B., Kokkola, Arto, Lips, Daan J., Lof, Sanne, Luyer, Misha D.P., Manzoni, Alberto, Marudanayagam, Ravi, de Pastena, Matteo, Pecorelli, Nicolò, Primrose, John N., Ricci, Claudio, Salvia, Roberto, Sandström, Per, Vissers, Frederique L.I.M., Wellner, Ulrich F., Zerbi, Alessandro, Dijkgraaf, Marcel G.W., Besselink, Marc G., and Abu Hilal, Mohammad

Published
2023
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12. Fluorescence‐guided surgery using cetuximab‐800CW in patients with penile carcinoma.

Author

Nijboer, Thomas S., van der Fels, Christa A. M., de Wit, Jaron G., Keizers, Bas, Huizinga, Henrik K., Voskuil, Floris J., Voskamp, Maarten J. H., van den Heuvel, Marius C., Witjes, Max J. H., and de Jong, Igle Jan

Subjects
PENILE cancer, PENILE transplantation, SURGICAL margin, SQUAMOUS cell carcinoma, SURGICAL equipment, ENDOTHELIAL growth factors
Abstract

Objective: To investigate the feasibility of fluorescence molecular imaging (FMI), using cetuximab‐800CW, as an intraoperative tool to determine surgical margins in penile squamous cell carcinoma (PSCC). Patients and methods: A total of 11 patients with PSCC received 75 mg cetuximab followed by 15 mg cetuximab‐800CW 2 days before surgery. FMI of the whole excision specimen and tissue slices was performed. Fluorescence visualisation was correlated to histopathology. Based on tumour and healthy tissue regions of interest, mean fluorescence intensity was calculated for each individual patient. Results: Significant differences between tumour and healthy mean fluorescence intensity were found with tumour‐to‐background ratios of a median (IQR) of 1.51 (0.99) and a mean (SD) of 1.51 (0.32) in the excision specimen and tissue slices, respectively. One patient showed a high relative fluorescence intensity with a signal‐to‐background ratio of 1.79, corresponding to a tumour‐positive margin on fresh frozen sectioning. Conclusion: In this Phase I study we showed that cetuximab‐800CW seems suitable to discriminate PSCC from background tissue. The tracer was well tolerated, and no false positive spots were seen. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Prolonged hypothermic machine perfusion enables daytime liver transplantation – an IDEAL stage 2 prospective clinical trial

Author

Brüggenwirth, Isabel M.A., primary, Lantinga, Veerle A., additional, Lascaris, Bianca, additional, Thorne, Adam M., additional, Meerdink, Mark, additional, de Kleine, Ruben H., additional, Blokzijl, Hans, additional, van den Berg, Aad P., additional, Reyntjens, Koen M.E.M., additional, Lisman, Ton, additional, Porte, Robert J., additional, de Meijer, Vincent E., additional, Brüggenwirth, Isabel M.A., additional, Moers, Cyril, additional, Monbaliu, Diethard, additional, Hofker, Sijbrand H., additional, Bottema, Jan, additional, Franke, Hildegaard S., additional, de Boer, Marieke T., additional, van den Boom, Anne Loes, additional, Buis, Carlijn I., additional, Fouraschen, Suomi M.G., additional, Hoogwater, Frederik J.H., additional, Klaase, Joost M., additional, de Kleine, Ruben H.J., additional, Nijkamp, Maarten W., additional, Rayar, A. Michel, additional, Cuperus, Frans J.C., additional, van der Heide, Frans, additional, van Vilsteren, Frederike G.I., additional, Abbasova, Ilhama F., additional, Fernhout, Meine H., additional, Meyer, Peter, additional, Muskiet, Ernesto R.R., additional, Vos, Jaap J., additional, Zeillemaker, Miriam, additional, Haring, Martijn P.D., additional, Pamplona, Carol C., additional, Veenma, Vivianne, additional, van Leeuwen, Otto B., additional, Bodewes, Silke B., additional, Adelmeijer, Jelle, additional, Wiersema-Buist, Janneke, additional, and van den Heuvel, Marius, additional

Published
2024
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15. Lessons learned from site-specific sampling and biological half-life of IGFII and IIE(68-88) peptide: a case study.

Author

Muller Kobold, Anneke C., de Haan, Jacco J., Bokkers, Reinoud P.H., Ruiter, Simeon J.S., van den Heuvel, Marius C., Lentjes, Eef G.W.M., Touw, Daan J., and de Jong, Koert P.

Subjects
PEPTIDES, HEPATIC veins, RENAL veins, INSULIN-like growth factor-binding proteins, SOMATOMEDIN A
Abstract

This article presents a case study on non-islet cell tumor induced hypoglycemia (NICTH), a rare condition associated with mesenchymal tumors. The study focuses on a patient with metastatic solitary fibrous tumors (SFT) and severe hypoglycemic symptoms. The researchers measured levels of insulin-like growth factor (IGF)-II and IIE(68-88) peptide in various sampling sites, including the hepatic vein draining the largest SFT metastasis. They also measured these substances in peripheral venous blood samples taken at different timepoints after tumor resection to determine their half-life and correlate the levels with tumor size and clinical parameters. The findings provide insight into the contribution of liver metastases to hormone production and highlight the importance of site-specific sampling in understanding the metabolism of tumor cells. However, the study suggests that site-specific sampling may have limited value in identifying the dominant hormone-producing site in patients with SFT. [Extracted from the article]

Published
2024
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17. Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions.

Author

Li, Mei, Larsen, Frederik T., van den Heuvel, Marius C., Gier, Konstanze, Gorter, Alan R., Oosterhuis, Dorenda, Bijzet, Johan, de Meijer, Vincent E., Ravnskjaer, Kim, Nagelkerke, Anika, and Olinga, Peter

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare problem with limited therapeutic options. Progress in this field depends on the availability of reliable preclinical models. Human precision-cut liver slices (PCLSs) have been employed to replicate the initiation of MASLD, but a comprehensive investigation into MASLD progression is still missing. This study aimed to extend the current incubation time of human PCLSs to examine different stages in MASLD. Healthy human PCLSs were cultured for up to 96 h in a medium enriched with high sugar, high insulin, and high fatty acids to induce MASLD. PCLSs displayed hepatic steatosis, characterized by accumulated intracellular fat. The development of hepatic steatosis appeared to involve a time-dependent impact on lipid metabolism, with an initial increase in fatty acid uptake and storage, and a subsequent down-regulation of lipid oxidation and secretion. PCLSs also demonstrated liver inflammation, including increased pro-inflammatory gene expression and cytokine production. Additionally, liver fibrosis was also observed through the elevated production of pro-collagen 1a1 and tissue inhibitor of metalloproteinase-1 (TIMP1). RNA sequencing showed that the tumor necrosis factor alpha (TNFα) signaling pathway and transforming growth factor beta (TGFβ) signaling pathway were consistently activated, potentially contributing to the development of inflammation and fibrosis. In conclusion, the prolonged incubation of human PCLSs can establish a robust ex vivo model for MASLD, facilitating the identification and evaluation of potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

Author

Kluiver, Thomas A, primary, Lu, Yuyan, additional, Schubert, Stephanie A, additional, Kraaier, Lianne J, additional, Ringnalda, Femke, additional, Lijnzaad, Philip, additional, DeMartino, Jeff, additional, Megchelenbrink, Wout L, additional, Amo-Addae, Vicky, additional, Eising, Selma, additional, de Faria, Flavia W, additional, Munter, Daniel J, additional, van de Wetering, Marc, additional, Kerl, Kornelius, additional, Duiker, Evelien, additional, van den Heuvel, Marius, additional, de Meijer, Vincent E, additional, de Kleine, Ruben H, additional, de Krijger, Ronald R, additional, Molenaar, Jan J, additional, Margaritis, Thanasis, additional, Stunnenberg, Henk, additional, Zsiros, Jozsef, additional, Clevers, Hans, additional, and Peng, Weng Chuan, additional

Published
2023
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20. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study

Author

Knobbe, Tim J., primary, Kremer, Daan, additional, Douwes, Rianne M., additional, Eisenga, Michele F., additional, Gomes-Neto, António W., additional, Annema, Coby, additional, Swarte, J. Casper, additional, Klont, Frank, additional, Navis, Gerjan, additional, Berger, Stefan P., additional, Bakker, Stephan J.L., additional, Blokzijl, Hans, additional, Bodewes, Frank A.J.A., additional, de Boer, Marieke T., additional, Damman, Kevin, additional, de Borst, Martin H., additional, Diepstra, Arjan, additional, Dijkstra, Gerard, additional, Doorenbos, Caecilia S.E., additional, Erasmus, Michiel E., additional, Gan, C. Tji, additional, Hak, Eelko, additional, Hepkema, Bouke G., additional, Leuvenink, Henri G.D., additional, Lexmond, Willem S., additional, de Meijer, Vincent E., additional, Niesters, Hubert G.M., additional, van Pelt, L. Joost, additional, Pol, Robert A., additional, Porte, Robert J., additional, Ranchor, Adelta V., additional, Sanders, Jan Stephan F., additional, Siebelink, Marion J., additional, Slart, Riemer J.H.J.A., additional, Touw, Daan J., additional, van den Heuvel, Marius C., additional, van Leer-Buter, Coretta, additional, van Londen, Marco, additional, Verschuuren, Erik A.M., additional, Vos, Michel J., additional, and Weersma, Rinse K., additional

Published
2023
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21. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

Author

Korrel, Maarten, primary, Jones, Leia R., additional, van Hilst, Jony, additional, Balzano, Gianpaolo, additional, Björnsson, Bergthor, additional, Boggi, Ugo, additional, Bratlie, Svein Olav, additional, Busch, Olivier R., additional, Butturini, Giovanni, additional, Capretti, Giovanni, additional, Casadei, Riccardo, additional, Edwin, Bjørn, additional, Emmen, Anouk M.L.H., additional, Esposito, Alessandro, additional, Falconi, Massimo, additional, Groot Koerkamp, Bas, additional, Keck, Tobias, additional, de Kleine, Ruben H.J., additional, Kleive, Dyre B., additional, Kokkola, Arto, additional, Lips, Daan J., additional, Lof, Sanne, additional, Luyer, Misha D.P., additional, Manzoni, Alberto, additional, Marudanayagam, Ravi, additional, de Pastena, Matteo, additional, Pecorelli, Nicolò, additional, Primrose, John N., additional, Ricci, Claudio, additional, Salvia, Roberto, additional, Sandström, Per, additional, Vissers, Frederique L.I.M., additional, Wellner, Ulrich F., additional, Zerbi, Alessandro, additional, Dijkgraaf, Marcel G.W., additional, Besselink, Marc G., additional, Abu Hilal, Mohammad, additional, Alseidi, Adnan, additional, Aquilano, Constanza, additional, Arola, Johanna, additional, Bianchi, Denise, additional, Brown, Rachel, additional, Campani, Daniela, additional, ChinAleong, Joanne, additional, Cros, Jerome, additional, Dimitrova, Lyubomira, additional, Doglioni, Claudio, additional, Dokmak, Safi, additional, Dorer, Russell, additional, Doukas, Michael, additional, Fabre, Jean Michel, additional, Ferrari, Giovanni, additional, Grinevich, Viacheslay, additional, Gobbo, Stefano, additional, Hackert, Thilo, additional, van den Heuvel, Marius, additional, Huijsentruijt, Clement, additional, Iglesias, Mar, additional, Jansen, Casper, additional, Khatkov, Igor, additional, Kooby, David, additional, Lena, Marco, additional, Luchini, Claudio, additional, Menon, Krishna, additional, Michenet, Patrick, additional, Molenaar, Quintus, additional, Nedkova, Anna, additional, Pietrabissa, Andrea, additional, Raicu, Mihaela, additional, Rajak, Rushda, additional, Rankovic, Branislava, additional, Rendek, Aniko, additional, Riviere, Benjamin, additional, Cunha, Antonio Sa, additional, Marc, Olivier Saint, additional, Velazquez, Patricia Sanchez, additional, Santini, Donatella, additional, Scarpa, Aldo, additional, Sebagh, Mylene, additional, Sears, Donald, additional, Shah, Mihir, additional, Soonawalla, Zahir, additional, Spaggiari, Paola, additional, Tharun, Lars, additional, Tholfsen, Tore, additional, Tomazic, Ales, additional, Vanoli, Alessandro, additional, Verbeke, Caroline, additional, Verheij, Joanne, additional, Von Winterfeld, Moritz, additional, de Wilde, Roeland, additional, Yip, Vincent, additional, and Zen, Yoh, additional

Published
2023
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24. Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion

Author

de Jong, Iris E.M., primary, Bodewes, Silke B., additional, van Leeuwen, Otto B., additional, Oosterhuis, Dorenda, additional, Lantinga, Veerle A., additional, Thorne, Adam M., additional, Lascaris, Bianca, additional, van den Heuvel, Marius C., additional, Wells, Rebecca G., additional, Olinga, Peter, additional, de Meijer, Vincent E., additional, and Porte, Robert J., additional

Published
2023
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26. Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study)

Author

Lluís, Núria, primary, Serradilla-Martín, Mario, additional, Achalandabaso, Mar, additional, Jehaes, François, additional, Dasari, Bobby V.M., additional, Mambrilla-Herrero, Sara, additional, Sparrelid, Ernesto, additional, Balakrishnan, Anita, additional, Hoogwater, Frederik J.H., additional, Amaral, Maria J., additional, Andersson, Bodil, additional, Berrevoet, Frederik, additional, Doussot, Alexandre, additional, López-López, Víctor, additional, Alsammani, Mohammedsuror, additional, Detry, Olivier, additional, Domingo-del Pozo, Carlos, additional, Machairas, Nikolaos, additional, Pekli, Damján, additional, Alcázar-López, Cándido F., additional, Asbun, Horacio, additional, Björnsson, Bergthor, additional, Christophides, Thalis, additional, Díez-Caballero, Alberto, additional, Francart, David, additional, Noel, Colin B., additional, Sousa-Silva, Donzília, additional, Toledo-Martínez, Enrique, additional, Tzimas, George N., additional, Yaqub, Sheraz, additional, Cauchy, François, additional, Prieto-Calvo, Mikel, additional, D’Souza, Melroy A., additional, Spiers, Harry V.M., additional, van den Heuvel, Marius C., additional, Charco, Ramón, additional, Lesurtel, Mickaël, additional, and Ramia, José M., additional

Published
2023
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27. Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study)

Author

Lluis, Nuria, Serradilla-Martin, Mario, Achalandabaso, Mar, Jehaes, Francois, Dasari, Bobby V. M., Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J. H., Amaral, Maria J., Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, Lopez-Lopez, Victor, Alsammani, Mohammedsuror, Detry, Olivier, Domingo-del Pozo, Carlos, Machairas, Nikolaos, Pekli, Damjan, Alcazar-Lopez, Candido F., Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Diez-Caballero, Alberto, Francart, David, Noel, Colin B., Sousa-Silva, Donzilia, Toledo-Martinez, Enrique, Tzimas, George N., Yaqub, Sheraz, Cauchy, Francois, Prieto-Calvo, Mikel, DSouza, Melroy A., Spiers, Harry V. M., van den Heuvel, Marius C., Charco, Ramon, Lesurtel, Mickael, Ramia, Jose M., Lluis, Nuria, Serradilla-Martin, Mario, Achalandabaso, Mar, Jehaes, Francois, Dasari, Bobby V. M., Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J. H., Amaral, Maria J., Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, Lopez-Lopez, Victor, Alsammani, Mohammedsuror, Detry, Olivier, Domingo-del Pozo, Carlos, Machairas, Nikolaos, Pekli, Damjan, Alcazar-Lopez, Candido F., Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Diez-Caballero, Alberto, Francart, David, Noel, Colin B., Sousa-Silva, Donzilia, Toledo-Martinez, Enrique, Tzimas, George N., Yaqub, Sheraz, Cauchy, Francois, Prieto-Calvo, Mikel, DSouza, Melroy A., Spiers, Harry V. M., van den Heuvel, Marius C., Charco, Ramon, Lesurtel, Mickael, and Ramia, Jose M.

Abstract

Background/Purpose:Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers. Methods:A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between 1 January 2010 and 31 December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association. The textbook outcome (TO) was defined as a non-prolonged length of hospital stay plus the absence of any Clavien-Dindo grade at least III complications, readmission, or mortality within 90 postoperative days. Results:A total of 28 centers contributed 85 patients who underwent surgery for IPNB. The median age was 66 years (55-72), 49.4% were women, and 87.1% were Caucasian. Open surgery was performed in 72 patients (84.7%) and laparoscopic in 13 (15.3%). TO was achieved in 54.1% of patients, reaching 63.8% after liver resection and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI: 50-82). Overall survival was better in patients with Charlson comorbidity score 4 or less versus more than 4 (P=0.016), intrahepatic versus extrahepatic tumor (P=0.027), single versus multiple tumors (P=0.007), those who underwent hepatic versus pancreatic resection (P=0.017), or achieved versus failed TO (P=0.029). Multivariable Cox regression analysis showed that not achieving TO (HR: 4.20; 95% CI: 1.11-15.94; P=0.03) was an independent prognostic factor of poor overall survival. Conclusions:Patients undergoing liver resection for IPNB were more likely to achieve a TO outcome than those requiring a pancreatic resection. Comorbidity, tumor location, and tumor multiplicity influenced overall survival. TO was an independent prognostic factor of overall survival.

Published
2023
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28. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients:Results From the TransplantLines Biobank and Cohort Study

Author

Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., Bakker, Stephan J.L., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., Bakker, Stephan J.L., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., and Weersma, Rinse K.

Abstract

Rationale & Objective: Prior studies report that the use of proton pump inhibitors (PPIs) can adversely affect gut microbiota and gastrointestinal uptake of micronutrients, in particular iron and magnesium, and are used frequently by kidney transplant recipients. Altered gut microbiota, iron deficiency, and magnesium deficiency have been implicated in the pathogenesis of chronic fatigue. Therefore, we hypothesized that PPI use may be an important and underappreciated cause of fatigue and reduced health-related quality of life (HRQoL) in this population. Study Design: Cross-sectional study. Setting & Participants: Kidney transplant recipients (≥1 year after transplantation) enrolled in the TransplantLines Biobank and Cohort Study. Exposure: PPI use, PPI type, PPI dosage, and duration of PPI use. Outcome: Fatigue and HRQoL, assessed using the validated Checklist Individual Strength 20 Revised questionnaire and Short Form-36 questionnaire. Analytical Approach: Logistic and linear regression. Results: We included 937 kidney transplant recipients (mean age 56 ± 13 years, 39% female) at a median of 3 (1-10) years after transplantation. PPI use was associated with fatigue severity (regression coefficient 4.02, 95% CI, 2.18 to 5.85, P < 0.001), a higher risk of severe fatigue (OR 2.05, 95% CI, 1.48 to 2.84, P < 0.001), lower physical HRQoL (regression coefficient −8.54, 95% CI, −11.54 to −5.54, P < 0.001), and lower mental HRQoL (regression coefficient −4.66, 95% CI, −7.15 to −2.17, P < 0.001). These associations were independent of potential confounders including age, time since transplantation, history of upper gastrointestinal disease, antiplatelet therapy, and the total number of medications. They were present among all individually assessed PPI types and were dose dependent. Duration of PPI exposure was only associated with fatigue severity. Limitations: Residual confounding and inability to assess causal relationships. Conclusions: PPI use is in

Published
2023

29. Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion

Author

De Jong, Iris E.M., Bodewes, Silke B., Van Leeuwen, Otto B., Oosterhuis, Dorenda, Lantinga, Veerle A., Thorne, Adam M., Lascaris, Bianca, Van Den Heuvel, Marius C., Wells, Rebecca G., Olinga, Peter, De Meijer, Vincent E., Porte, Robert J., De Jong, Iris E.M., Bodewes, Silke B., Van Leeuwen, Otto B., Oosterhuis, Dorenda, Lantinga, Veerle A., Thorne, Adam M., Lascaris, Bianca, Van Den Heuvel, Marius C., Wells, Rebecca G., Olinga, Peter, De Meijer, Vincent E., and Porte, Robert J.

Abstract

Background. End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor livers prior to transplantation. The objective of this study was to provide support for bile composition as a marker of biliary viability and to investigate whether bile ducts of high-risk human donor livers already undergo repair during NMP. Methods. Forty-two livers that were initially declined for transplantation were included in our NMP clinical trial. After NMP, livers were either secondary declined (n = 17) or accepted for transplantation (n = 25) based on the chemical composition of bile and perfusate samples. Bile duct biopsies were taken before and after NMP and assessed using an established histological injury severity scoring system and a comprehensive immunohistochemical assessment focusing on peribiliary glands (PBGs), vascular damage, and regeneration. Results. Bile ducts of livers that were transplanted after viability testing during NMP showed better preservation of PBGs, (micro)vasculature, and increased cholangiocyte proliferation, compared with declined livers. Biliary bicarbonate, glucose, and pH were confirmed as accurate biomarkers of bile duct vitality. In addition, we found evidence of PBG-based progenitor cell differentiation toward mature cholangiocytes during NMP. Conclusions. Favorable bile chemistry during NMP correlates well with better-preserved biliary microvasculature and PBGs, with a preserved capacity for biliary regeneration. During NMP, biliary tree progenitor cells start to differentiate toward mature cholangiocytes, facilitating restoration of the ischemically damaged surface epithelium.

Published
2023

35. Plasma Lead Concentration and Risk of Late Kidney Allograft Failure: Findings From the TransplantLines Biobank and Cohort Studies

Author

Sotomayor, Camilo G., primary, Giubergia, Flavia, additional, Groothof, Dion, additional, Ferreccio, Catterina, additional, Nolte, Ilja M., additional, Navis, Gerjan J., additional, Gomes-Neto, Antonio W., additional, Kremer, Daan, additional, Knobbe, Tim J., additional, Eisenga, Michele F., additional, Rodrigo, Ramón, additional, Touw, Daan J., additional, Bakker, Stephan J.L., additional, Damman, Kevin, additional, de Meijer, Vincent E., additional, Porte, Robert J., additional, de Boer, Marieke T., additional, Leuvenink, Henri G.D., additional, Pol, Robert A., additional, Annema, Coby, additional, Ranchor, Adelita V., additional, Siebelink, Marion J., additional, Lexmond, Willem S., additional, Hepkema, Bouke G., additional, Joost van Pelt, L., additional, Gan, C. Tji, additional, Verschuuren, Erik A.M., additional, Bodewes, Frank A.J.A., additional, Dijkstra, Gerard, additional, Blokzijl, Hans J., additional, Niesters, Bert H.G.M., additional, Sanders, Jan-Stephan F., additional, Grootjans, Heleen, additional, Douwes, Rianne M., additional, Gomes-Neto, António W., additional, Slart, Riemer H.J.A., additional, Erasmus, Michiel E., additional, van Leer-Buter, Coretta, additional, van Londen, Marco, additional, Timens, Wim, additional, Diepstra, Arjan, additional, van den Heuvel, Marius C., additional, Schutten, Joëlle C., additional, Swarte, Cas, additional, Weersma, Rinse K., additional, Heiner-Fokkema, Rebecca, additional, Vos, Michel, additional, Klont, Frank, additional, and Hak, Eelko, additional

Published
2022
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36. Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney

Author

Tiller, Gesa, primary, Lammerts, Rosa G. M., additional, Karijosemito, Jessy J., additional, Alkaff, Firas F., additional, Diepstra, Arjan, additional, Pol, Robert A., additional, Meter-Arkema, Anita H., additional, Seelen, Marc. A., additional, van den Heuvel, Marius C., additional, Hepkema, Bouke G., additional, Daha, Mohamed R., additional, van den Born, Jacob, additional, and Berger, Stefan P., additional

Published
2022
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37. Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of posttransplant nonanastomotic strictures

Author

de Jong, Iris E. M., primary, Overi, Diletta, additional, Carpino, Guido, additional, Gouw, Annette S. H., additional, van den Heuvel, Marius C., additional, van Kempen, Léon C., additional, Mancone, Carmine, additional, Onori, Paolo, additional, Cardinale, Vincenzo, additional, Casadei, Luca, additional, Alvaro, Domenico, additional, Porte, Robert J., additional, and Gaudio, Eugenio, additional

Published
2021
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38. Nonmalignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin‐rich thrombus

Author

Driever, Ellen G., primary, von Meijenfeldt, Fien A., additional, Adelmeijer, Jelle, additional, de Haas, Robbert J., additional, van den Heuvel, Marius C., additional, Nagasami, Chandrasekaran, additional, Weisel, John W., additional, Fondevila, Constantino, additional, Porte, Robert J., additional, Blasi, Anabel, additional, Heaton, Nigel, additional, Gregory, Stephen, additional, Kane, Pauline, additional, Bernal, William, additional, Zen, Yoh, additional, and Lisman, Ton, additional

Published
2021
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43. Magnetic resonance imaging assessment of renal flow distribution patterns during ex vivo normothermic machine perfusion in porcine and human kidneys

Author

Schutter, Rianne, primary, Lantinga, Veerle A., additional, Hamelink, Tim L., additional, Pool, Merel B. F., additional, Varsseveld, Otis C., additional, Potze, Jan Hendrik, additional, Hillebrands, Jan‐Luuk, additional, van den Heuvel, Marius C., additional, Dierckx, Rudi A. J. O., additional, Leuvenink, Henri G. D., additional, Moers, Cyril, additional, and Borra, Ronald J. H., additional

Published
2021
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48. Corrigendum to ‘Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial’ (Br J Anaesth 2017; 118: 720–32)

Author

Nieuwenhuijs-Moeke, Gertrude J., primary, Nieuwenhuijs, Vincent B., additional, Seelen, Marc A.J., additional, Berger, Stefan P., additional, van den Heuvel, Marius C., additional, Burgerhof, Johannes G.M., additional, Ottens, Petra J., additional, Ploeg, Rutger J., additional, Leuvenink, Henri G.D., additional, and Struys, Michel M.R.F., additional

Published
2021
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