10 results on '"van den Bouwhuijsen Q"'
Search Results
2. Multispectral MRI centerline tracking in carotid arteries
- Author
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Tang, H. (author), Van Walsum, T. (author), Van Onkelen, R.S. (author), Klein, S. (author), Hameeteman, R. (author), Schaap, M. (author), Van den Bouwhuijsen, Q. (author), Witteman, J.C.M. (author), Van der Lugt, A. (author), Van Vliet, L.J. (author), Niessen, W.J. (author), Tang, H. (author), Van Walsum, T. (author), Van Onkelen, R.S. (author), Klein, S. (author), Hameeteman, R. (author), Schaap, M. (author), Van den Bouwhuijsen, Q. (author), Witteman, J.C.M. (author), Van der Lugt, A. (author), Van Vliet, L.J. (author), and Niessen, W.J. (author)
- Abstract
We propose a minimum cost path approach to track the centerlines of the internal and external carotid arteries in multispectral MR data. User interaction is limited to the annotation of three seed points. The cost image is based on both a measure of vessel medialness and lumen intensity similarity in two MRA image sequences: Black Blood MRA and Phase Contrast MRA. After intensity inhomogeneity correction and noise reduction, the two images are aligned using affine registration. The two parameters that control the contrast of the cost image were determined in an optimization experiment on 40 training datasets. Experiments on the training datasets also showed that a cost image composed of a combination of gradient-based medialness and lumen intensity similarity increases the tracking accuracy compared to using only one of the constituents. Furthermore, centerline tracking using both MRA sequences outperformed tracking using only one of these MRA images. An independent test set of 152 images from 38 patients served to validate the technique. The centerlines of 148 images were successfully extracted using the parameters optimized on the training sets. The average mean distance to the reference standard, manually annotated centerlines, was 0.98 mm, which is comparable to the in-plane resolution. This indicates that the proposed method has a high potential to replace the manual centerline annotation., Image Science and Technology, Applied Sciences
- Published
- 2011
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3. Atherosclerotic plaque in the left carotid artery is more vulnerable than at the contralateral side
- Author
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Selwaness, M., primary, Van Den Bouwhuijsen, Q., additional, Van Onkelen, R. S., additional, Hofman, A., additional, Franco, O. H., additional, Witteman, J., additional, Wentzel, J. J., additional, and Van Der Lugt, A., additional
- Published
- 2013
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4. Arterial stiffness is associated with carotid intraplaque hemorrhage in the general population: the Rotterdam study
- Author
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Selwaness, M., primary, Van Den Bouwhuijsen, Q., additional, Mattace-Raso, F. U. S., additional, Verwoert, G. C., additional, Hofman, A., additional, Franco, O. H., additional, Van Der Lugt, A., additional, Witteman, J., additional, and Wentzel, J. J., additional
- Published
- 2013
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5. Determinants of magnetic resonance imaging detected carotid plaque components: the Rotterdam Study
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van den Bouwhuijsen, Q. J. A., primary, Vernooij, M. W., additional, Hofman, A., additional, Krestin, G. P., additional, van der Lugt, A., additional, and Witteman, J. C. M., additional
- Published
- 2011
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6. Carotid Plaque Morphology and Ischemic Vascular Brain Disease on MRI.
- Author
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van den Bouwhuijsen QJA, Vernooij MW, Verhaaren BFJ, Vrooman HA, Niessen WJ, Krestin GP, Ikram MA, Franco OH, and van der Lugt A
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- Aged, Brain Ischemia diagnostic imaging, Brain Ischemia epidemiology, Carotid Arteries diagnostic imaging, Carotid Arteries pathology, Carotid Stenosis diagnostic imaging, Carotid Stenosis pathology, Female, Hemorrhage complications, Hemorrhage diagnostic imaging, Hemorrhage pathology, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic pathology, Risk Factors, White Matter diagnostic imaging, White Matter pathology, Brain Ischemia etiology, Carotid Stenosis complications, Plaque, Atherosclerotic complications
- Abstract
Background and Purpose: Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging., Materials and Methods: From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging. The presence of intraplaque hemorrhage, lipid core, and calcification and measures of plaque size was assessed in both carotid arteries. The presence of plaque characteristics in relation to lacunar and cortical infarcts and white matter lesion volume was investigated and adjusted for cardiovascular risk factors. Stratified analyses were conducted to explore effect modification by sex. Additional analyses were conducted per carotid artery in relation to vascular brain disease in the ipsilateral hemisphere., Results: Carotid intraplaque hemorrhage was significantly associated with the presence of cortical infarcts (OR, 1.9; 95% confidence interval, 1.1-3.3). None of the plaque characteristics were related to the presence of lacunar infarcts. Calcification was the only characteristic that was associated with higher white matter lesion volume. There was no significant interaction by sex., Conclusions: The presence of carotid intraplaque hemorrhage on MR imaging is independently associated with MR imaging-defined cortical infarcts, but not with lacunar infarcts. Plaque calcification, but not vulnerable plaque components, is related to white matter lesion volume., (© 2017 by American Journal of Neuroradiology.)
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- 2017
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7. Determinants of carotid atherosclerotic plaque burden in a stroke-free population.
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Selwaness M, Hameeteman R, Van 't Klooster R, Van den Bouwhuijsen Q, Hofman A, Franco OH, Niessen WJ, Klein S, Vernooij MW, Van der Lugt A, and Wentzel JJ
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- Aged, Aged, 80 and over, Carotid Arteries chemistry, Carotid Arteries pathology, Carotid Stenosis blood, Carotid Stenosis epidemiology, Carotid Stenosis pathology, Comorbidity, Female, Hemorrhage pathology, Humans, Image Interpretation, Computer-Assisted, Lipids analysis, Male, Middle Aged, Netherlands epidemiology, Predictive Value of Tests, Risk Factors, Severity of Illness Index, Sex Factors, Smoking adverse effects, Smoking epidemiology, Carotid Arteries diagnostic imaging, Carotid Stenosis diagnostic imaging, Magnetic Resonance Imaging, Plaque, Atherosclerotic
- Abstract
Background and Aims: In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis., Methods: The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm
3 ), wall volume (outer wall-inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis., Results: We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8% vs. 49.2 ± 7.7%, p < 0.0001) and smaller lumen volumes (933 ± 286 mm3 vs. 1078 ± 334 mm3 , p < 0.0001) than men. In women, age, HDL-cholesterol and systolic blood pressure, and in men, total cholesterol, non-HDL cholesterol and statin use were independently associated with higher plaque burden and lumen volume. Furthermore, smoking and diabetes were associated with lumen volume in men (respectively p = 0.04 and p = 0.002). Intraplaque hemorrhage (IPH) and lipid were related to a larger plaque burden (OR 1.30 [1.05-1.60] and OR 1.28[1.06-1.55]). Finally, within the highest quartile of plaque burden, IPH was strongly associated with luminal stenosis independent of age, sex, plaque burden and composition (Beta = 15.2; [11.8-18.6])., Conclusions: Several cardiovascular risk factors and plaque components, in particular IPH, are associated with higher plaque burden. Carotid IPH is strongly associated with an increased luminal stenosis., (Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)- Published
- 2016
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8. Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease.
- Author
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Selwaness M, Bos D, van den Bouwhuijsen Q, Portegies ML, Ikram MA, Hofman A, Franco OH, van der Lugt A, Wentzel JJ, and Vernooij MW
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- Aged, Aged, 80 and over, Brain Ischemia complications, Brain Ischemia diagnostic imaging, Carotid Arteries diagnostic imaging, Carotid Artery Diseases epidemiology, Carotid Intima-Media Thickness, Carotid Stenosis diagnostic imaging, Cohort Studies, Coronary Disease complications, Female, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Male, Middle Aged, Netherlands epidemiology, Plaque, Atherosclerotic epidemiology, Prospective Studies, Risk Factors, Sex Factors, Stroke complications, Stroke epidemiology, Carotid Artery Diseases diagnostic imaging, Coronary Disease diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Stroke diagnostic imaging
- Abstract
Background and Purpose: Because atherosclerosis is a systemic disease, presence and composition on 1 location may relate to ischemic events in distant locations. We examined whether carotid atherosclerotic wall thickness, stenosis, and plaque composition are related to history of ischemic stroke and coronary heart disease (CHD)., Methods: From the population-based Rotterdam Study, 1731 asymptomatic participants (mean age, 72.4±9.1 years; 55% males) underwent magnetic resonance imaging of both carotid arteries. We assessed carotid wall thickness, stenosis and plaque composition, that is presence of intraplaque hemorrhage, lipid, and calcification. History of ischemic stroke and CHD was assessed until date of magnetic resonance imaging. The study was approved by the institutional review board, and all participants gave informed consent. Logistic regression analyses adjusted for age and traditional cardiovascular risk factors were used to study sex-specific associations between plaque characteristics and clinical events., Results: We found that both carotid stenosis and intraplaque hemorrhage were associated with ischemic stroke in men but not in women (men: odds ratio [OR] for stenosis [per 10% increase]: 1.17 [95% CI, 1.06-1.30] and for intraplaque hemorrhage 2.39 [95% CI, 1.32-4.35]). In both men and women, carotid stenosis was associated with CHD (men: OR per 10% increase 1.12 [95% CI, 1.04-1.21] and women: OR, 1.17 [95% CI, 1.03-1.34]) and carotid wall thickness was associated with CHD (men: OR, 1.20 [95% CI, 1.03-1.39] and women: OR, 1.21 [95% CI, 0.88-1.65]). None of the plaque components was associated with CHD., Conclusions: Whereas carotid plaque thickness and stenosis are associated with the history of ischemic stroke and CHD, carotid intraplaque hemorrhage is associated with ischemic stroke, but not with CHD, providing novel insights into the pathogenesis of cardiovascular events., (© 2016 American Heart Association, Inc.)
- Published
- 2016
- Full Text
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9. Atherosclerotic plaque in the left carotid artery is more vulnerable than in the right.
- Author
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Selwaness M, van den Bouwhuijsen Q, van Onkelen RS, Hofman A, Franco OH, van der Lugt A, Wentzel JJ, and Vernooij M
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- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic epidemiology, Prospective Studies, Radiography, Risk Factors, Carotid Arteries diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Population Surveillance methods
- Abstract
Background and Purpose: Ischemic stroke is more often diagnosed in the left hemisphere than in the right. It is unknown whether this asymmetrical prevalence relates to differences in carotid atherosclerosis. We compared atherosclerotic plaque prevalence, severity, and composition between left and right carotid arteries., Methods: In a population-based cohort, carotid MRI scanning was performed in 1414 stroke-free participants (≥45 years). Using a multisequence MRI protocol, we assessed the prevalence, stenosis, and thickness of the plaque and its predominant component (ie, lipid core, intraplaque hemorrhage, calcification, or fibrous tissue in each carotid artery). Differences between left and right side were tested using paired t tests, McNemar test and Generalized Estimating Equation analyses., Results: The majority (85%) of the participants had bilateral carotid plaques. Unilateral plaques were twice more prevalent on the left than on the right side (67% versus 33%; P<0.001). Plaque thickness was also greater on the left (3.1±1.2 versus 2.9±1.3 mm; P<0.001); degree of stenosis did not differ. Intraplaque hemorrhage and fibrous tissue were more prevalent on the left (9.1 versus 5.9%; P<0.001 and 45.0 versus 38.5%; P<0.001), whereas calcification occurred more often on the right (37.4 versus 31.6% at the left; P<0.001). Lipid was equally distributed., Conclusions: Carotid atherosclerotic plaque size and composition are not symmetrically distributed. Predominance of intraplaque hemorrhage in left-sided carotid plaques suggests a greater vulnerability as opposed to right-sided plaques, which are more calcified and therefore considered more stable., (© 2014 American Heart Association, Inc.)
- Published
- 2014
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10. Arterial stiffness is associated with carotid intraplaque hemorrhage in the general population: the Rotterdam study.
- Author
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Selwaness M, van den Bouwhuijsen Q, Mattace-Raso FU, Verwoert GC, Hofman A, Franco OH, Witteman JC, van der Lugt A, Vernooij MW, and Wentzel JJ
- Subjects
- Aged, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases epidemiology, Disease Progression, Female, Hemorrhage epidemiology, Humans, Logistic Models, Magnetic Resonance Angiography, Male, Middle Aged, Multivariate Analysis, Netherlands epidemiology, Odds Ratio, Prevalence, Prospective Studies, Pulse Wave Analysis, Risk Factors, Rupture, Spontaneous, Ultrasonography, Vascular Calcification epidemiology, Vascular Calcification physiopathology, Carotid Artery Diseases physiopathology, Hemorrhage physiopathology, Plaque, Atherosclerotic, Vascular Stiffness
- Abstract
Objective: The relation between arterial stiffness and atherosclerosis, and specifically the influence of arterial stiffness on plaque composition, is largely unknown. In a population-based study, we investigated the association between arterial stiffness and the presence and composition of carotid atherosclerotic plaques., Approach and Results: Arterial stiffness was measured in 6527 participants (67.0±8.6 years) using aortic pulse wave velocity (PWV). Presence of carotid atherosclerotic plaques was assessed with ultrasound. Subsequently, 1059 subjects with carotid plaques (>2.5 mm) underwent MRI to assess plaque composition (presence of intraplaque hemorrhage, lipid, and calcification). Generalized estimation equation analyses adjusted for age, sex, mean arterial pressure, heart rate, carotid wall thickening, pulse pressure, and traditional cardiovascular risk factors were used to study the association between PWV and the presence and composition of carotid atherosclerotic plaques. In multivariable analysis, higher PWV was independently related to higher prevalence of carotid atherosclerotic plaque on ultrasound (odds ratio for highest quartile of PWV compared with lowest quartile, 1.24 [95% confidence interval, 1.02-1.51]). Furthermore, higher PWV was associated with intraplaque hemorrhage (age- and sex-adjusted odds ratio per SD increase in PWV, 1.20 [1.04-1.38] and calcification, 1.18 [1.03-1.35]), but not with lipid. After adjustment for cardiovascular risk factors, PWV remained significantly associated with intraplaque hemorrhage (1.20 [1.01-1.43]). Additional adjustment for pulse pressure did not materially affect the effect estimate (1.19 [1.00-1.42])., Conclusions: Higher PWV is associated with presence and composition of carotid atherosclerotic plaques, in particular with intraplaque hemorrhage. These findings provide further clues for understanding the development of vulnerable atherosclerotic plaque.
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- 2014
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