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1. Adjuvant immunotherapy in older patients with stage III and resected stage IV melanoma: Toxicity and recurrence-free survival outcomes from the Dutch melanoma treatment registry

Author

Özkan, A., Kapiteijn, E., van den Bos, F., Aarts, M.J.B., van den Berkmortel, F.W.P.J., Blank, C.U., Bloem, M., Blokx, W.A.M., Boers-Sonderen, M.J., Bonenkamp, J.J., van den Eertwegh, A.J.M., de Groot, J.W.B., Haanen, J.B., Holtslag, C.E., Hospers, G.A.P., Piersma, D., van Rijn, R.S., Stevense-den Boer, A.M., Suijkerbuijk, K.P.M., van der Veldt, A.A.M., Vreugdenhil, G., Wouters, M.W.J.M., Portielje, J.E.A., and de Glas, N.A.

Published
2024
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4. Predictive value of selected geriatric parameters for postoperative outcomes in older patients with rectal cancer – A multicenter cohort study

Author

Argillander, T.E., van der Hulst, H.C., van der Zaag-Loonen, H.J., van Duijvendijk, P., Dekker, J.W.T., van der Bol, J.M., Bastiaannet, E., Verkuyl, J., Neijenhuis, P., Hamaker, M., Schiphorst, A.H., Aukema, T.S., Burghgraef, T.A., Sonneveld, D.J.A., Schuijtemaker, J.S., van der Meij, W., van den Bos, F., Portielje, J.E.A., Souwer, E.T.D., and van Munster, B.C.

Published
2022
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6. Geriatrische oncologie

Author

Portielje, J. E. A., de Glas, N. A., van den Bos, F., van Krieken, J.H.J.M., editor, Beets-Tan, R.G.H., editor, Gelderblom, A.J., editor, Olofsen, M.J.J., editor, and Rutten, H.J.T., editor

Published
2020
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9. Association between chemotherapy-related toxicity and QoL/ physical functioning in older patients

Author

Baltussen, J., primary, De Glas, N., additional, Van Holstein, Y., additional, Van der Elst, M., additional, Trompet, S., additional, den Boogaard, A. Uit, additional, Van der Plas-Krijgsman, W., additional, Labots, G., additional, Holterhues, C., additional, Van der Bol, J., additional, Mammatas, L., additional, Liefers, G.J., additional, Slingerland, M., additional, Van den Bos, F., additional, Mooijaart, S., additional, and Portielje, J., additional

Published
2023
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15. Association of Biological Age with Tumor Microenvironment in Patients with Esophageal Adenocarcinoma

Author

Ravensbergen, C.J., primary, Holstein, Y. van, additional, Hagenaars, S.C., additional, Crobach, A.S.L.P., additional, Trompet, S., additional, Portielje, J.E.A., additional, de Glas, N.A., additional, van Heemst, D., additional, van den Bos, F., additional, Tollenaar, R.A.E.M., additional, Mesker, W.E., additional, Mooijaart, S.P., additional, and Slingerland, M., additional

Published
2022
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17. The association of blood biomarkers with outcomes in older patients with solid tumors: a systematic review

Author

van Holstein, Y., primary, van den Berkmortel, P.J.E., additional, Trompet, S., additional, van Heemst, D., additional, Van den Bos, F., additional, Roemeling-van Rhijn, M., additional, De Glas, N.A., additional, Beekman, M., additional, Slagboom, P.E., additional, Portielje, J.E.A., additional, Mooijaart, S.P., additional, and Van Munster, B., additional

Published
2022
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18. Association of metabolomics mortality score with geriatric assessment and mortality in older patients with solid tumors

Author

van Holstein, Y., primary, Mooijaart, S.P., additional, Van Oevelen, M., additional, Van Deudekom, F.J., additional, Vojinovic, D., additional, Van den Bos, F., additional, Labots, G., additional, De Glas, N.A., additional, Beekman, M., additional, Van Munster, B., additional, Slagboom, P.E., additional, Portielje, J.E.A., additional, and Trompet, S., additional

Published
2022
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20. Frailty and Treatment Decisions in Older Patients with Vulvar Cancer

Author

Gans, E., primary, Portielje, J.E.A., additional, Dekkers, O.M., additional, de Kroon, C.D., additional, van Munster, B.C., additional, Derks, M.G.M., additional, Trompet, S., additional, van Holstein, Y., additional, Mooijaart, S.P., additional, van Poelgeest, M., additional, and van den Bos, F., additional

Published
2022
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23. Low skeletal muscle mass predicts frailty in elderly head and neck cancer patients

Author

MS Hoofd-Hals Chirurgische Oncologie, MS Radiologie, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Geriatrie, Meerkerk, C. D.A., Chargi, N., de Jong, P. A., van den Bos, F., de Bree, R., MS Hoofd-Hals Chirurgische Oncologie, MS Radiologie, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Geriatrie, Meerkerk, C. D.A., Chargi, N., de Jong, P. A., van den Bos, F., and de Bree, R.

Published
2022

25. Validation of the ACS NSQIP Surgical Risk Calculator in older patients with colorectal cancer undergoing elective surgery

Author

Van der Hulst, H., primary, Dekker, J.W.T., additional, Bastiaannet, E., additional, van der Bol, J., additional, van den Bos, F., additional, Hamaker, M.E., additional, Schiphorst, A., additional, Sonneveld, D.J.A., additional, Schuijtemaker, J.S., additional, de Jong, R.J., additional, Portielje, J.E.A., additional, and Souwer, E.T.D., additional

Published
2021
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26. Geriatric assessment and treatment outcomes in a Dutch cohort of older patients with esophageal cancer

Author

van Holstein, Y., primary, Trompet, S., additional, van Deudekom, F.J., additional, van Munster, B., additional, de Glas, N.A., additional, van den Bos, F., additional, Uit den Boogaard, A., additional, van der Elst, M.J.T., additional, van der Kaaij, M.A.E., additional, Neelis, K.J., additional, Langers, A.M.J., additional, Slingerland, M., additional, Portielje, J.E.A., additional, and Mooijaart, S.P., additional

Published
2021
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28. 142 Low preoperative skeletal muscle density predicts postoperative complications and functional decline in older women with ovarian cancer

Author

Van der Zanden, V, primary, Van Soolingen, NJ, additional, Viddeleer, A, additional, Trum, J, additional, Amant, F, additional, Mourits, MJE, additional, Portielje, J, additional, Van den Bos, F, additional, De Kroon, C, additional, Kagie, M, additional, Oei, S, additional, Baalbergen, A, additional, Jong, AMLDVan Haaften-de, additional, Houtsma, D, additional, Van Munster, B, additional, and Souwer, E, additional

Published
2021
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31. Temporal Dynamics of Depressive Symptoms and Cognitive Decline in the Oldest Old: Dynamic Time Warp analysis of the Leiden 85-plus Study.

Author

van der Slot, A. J., Bertens, A. S., Trompet, S., Mooijaart, S. P., Gussekloo, J., van den Bos, F., and Giltay, E. J.

Subjects
GERIATRIC Depression Scale, COGNITION disorders, COGNITIVE aging, MEDICAL personnel, MENTAL depression
Abstract

Introduction: The prevalence of depressive symptoms and cognitive decline increases with age, reducing quality of life. However, the temporal relationship between the two remains elusive. Objectives: We aimed to explore the temporal relationship between depressive symptoms and cognitive decline in individuals aged 85 years, during up to 5 years follow-up. Methods: Participants eligible for this study were selected from the Leiden 85-plus Study, who participated for at least 3 follow-up measurements. Depressive symptoms were assessed at baseline and at follow-up in a period of 6 yearly assessments, utilizing the 15-item Geriatric Depression Scale (GDS-15). Cognitive decline was measured through various tests including the Mini Mental State Exam (MMSE), Stroop Test, Letter Digit Coding Test, and immediate and delayed recall using the 12-word learning test. Dynamic Time Warping (DTW) analysis was employed to model their temporal dynamics, in undirected and directed analysis, to ascertain whether depressive symptoms precede cognitive decline, or vice versa. Results: The study included a total of 325 (54.2%) of 599 patients, of whom 68.0% were female, 45.0% with intermediate to higher education, and all aged 85 years. Depressive symptoms and cognitive functioning significantly covaried in time, and directed analyses showed that depressive symptoms preceded most of the parameters of cognitive decline in the oldest old. Of the 15 GDS symptoms, those with the strongest outstrength were worthlessness, hopelessness, low happiness, dropping activities/interests, and low satisfaction with life (all p<.01). Conclusions: We found a strong temporal link between depressive symptoms and subsequent cognitive decline in a population of the oldest old. This highlights the importance of a holistic approach that considers both mental and cognitive well-being in the aging population. As depressive symptoms were an early indicator of cognitive decline, it is of importance that healthcare professionals recognize and address depressive symptoms early to allow for appropriate interventions and support, to potentially mitigate the impact on cognitive decline. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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41. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

42. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

AIOS Psychiatrie, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 1, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, AIOS Psychiatrie, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 1, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

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