Author: "van de Groep, K" - Searchworks@Jio Institute Digital Library Search Results

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1. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

Author: Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. A., Denehy, L., Hart, N., Morris, P. E., Mortimore, J., Granger, C. L., Jensen, H. I., Piers, R., Van den Bulcke, B., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Van den Bulcke, B., Piers, R., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Ryan, C., Dawson, D., Ball, J., Noone, K., Aisling, B., Prudden, S., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Aron, J., Lumley, G., Milliken, D., Dhadwal, K., McGrath, B. A., Lynch, S. J., Bovento, B., Sharpe, G., Grainger, E., Pieri-Davies, S., Wallace, S., McGrath, B., Lynch, S. J., Bovento, B., Grainger, E., Pieri-Davies, S., Sharpe, G., Wallace, S., Jung, M., Cho, J., Park, H., Suh, G., Kousha, O., Paddle, J., Gripenberg, L. Gamrin, Rehal, M. Sundström, Wernerman, J., Rooyackers, O., de Grooth, H. J., Choo, W. P., Spoelstra-de Man, A. M., Swart, E. L., Oudemans-van Straaten, H. M., Talan, L., Güven, G., Altıntas, N. D., Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., Blaser, A. Reintam, Kalaiselvan, M. S., Arunkumar, A. S., Renuka, M. K., Shivkumar, R. L., Volbeda, M., ten Kate, D., Hoekstra, M., van der Maaten, J. M., Nijsten, M. W., Komaromi, A., Rooyackers, O., Wernerman, J., Norberg, Å., Smedberg, M., Mori, M., Pettersson, L., Norberg, Å., Rooyackers, O., Wernerman, J., Theodorakopoulou, M., Christodoulopoulou, T., Diamantakis, A., Frantzeskaki, F., Kontogiorgi, M., Chrysanthopoulou, E., Lygnos, M., Diakaki, C., Armaganidis, A., Gundogan, K., Dogan, E., Coskun, R., Muhtaroglu, S., Sungur, M., Ziegler, T., Guven, M., Kleyman, A., Khaliq, W., Andreas, D., Singer, M., Meierhans, R., Schuepbach, R., De Brito-Ashurst, I., Zand, F., Sabetian, G., Nikandish, R., Hagar, F., Masjedi, M., Maghsudi, B., Vazin, A., Ghorbani, M., Asadpour, E., Kao, K. C., Chiu, L. C., Hung, C. Y., Chang, C. H., Li, S. H., Hu, H. C., El Maraghi, S., Ali, M., Rageb, D., Helmy, M., Marin-Corral, J., Vilà, C., Masclans, J. R., Vàzquez, A., Martín-Loeches, I., Díaz, E., Yébenes, J. C., Rodriguez, A., Álvarez-Lerma, F., Varga, N., Cortina-Gutiérrez, A., Dono, L., Martínez-Martínez, M., Maldonado, C., Papiol, E., Pérez-Carrasco, M., Ferrer, R., Nweze, K., Morton, B., Welters, I., Houard, M., Voisin, B., Ledoux, G., Six, S., Jaillette, E., Nseir, S., Romdhani, S., Bouneb, R., Loghmari, D., Aicha, N. Ben, Ayachi, J., Meddeb, K., Chouchène, I., Khedher, A., Boussarsar, M., Chan, K. S., Yu, W. L., Marin-Corral, J., Vilà, C., Masclans, J. R., Nolla, J., Vidaur, L., Bonastre, J., Suberbiola, B., Guerrero, J. E., Rodriguez, A., Coll, N. Ramon, Jiménez, G. Jiménez, Brugger, S. Carvalho, Calero, J. Codina, Garrido, B. Balsera, García, M., Martínez, M. Palomar, Vidal, M. Vallverdú, de la Torre, M. C., Vendrell, E., Palomera, E., Güell, E., Yébenes, J. C., Serra-Prat, M., Bermejo-Martín, J. F., Almirall, J., Tomas, E., Escoval, A., Froe, F., Pereira, M. H. Vitoria, Velez, N., Viegas, E., Filipe, E., Groves, C., Reay, M., Chiu, L. C., Hu, H. C., Hung, C. Y., Chang, C. H., Li, S. H., Kao, K. C., Ballin, A., Facchin, F., Sartori, G., Zarantonello, F., Campello, E., Radu, C. M., Rossi, S., Ori, C., Simioni, P., Umei, N., Shingo, I., Santos, A. C., Candeias, C., Moniz, I., Marçal, R., e Silva, Z. Costa, Ribeiro, J. M., Georger, J. F., Ponthus, J. P., Tchir, M., Amilien, V., Ayoub, M., Barsam, E., Martucci, G., Panarello, G., Tuzzolino, F., Capitanio, G., Ferrazza, V., Carollo, T., Giovanni, L., Arcadipane, A., Sánchez, M. López, González-Gay, M. A., Díaz, F. J. Llorca, López, M. I. Rubio, Zogheib, E., Villeret, L., Nader, J., Bernasinski, M., Besserve, P., Caus, T., Dupont, H., Morimont, P., Habran, S., Hubert, R., Desaive, T., Blaffart, F., Janssen, N., Guiot, J., Pironet, A., Dauby, P., Lambermont, B., Zarantonello, F., Ballin, A., Facchin, F., Sartori, G., Campello, E., Pettenuzzo, T., Citton, G., Rossi, S., Simioni, P., Ori, C., Kirakli, C., Ediboglu, O., Ataman, S., Yarici, M., Tuksavul, F., Keating, S., Gibson, A., Gilles, M., Dunn, M., Price, G., Young, N., Remeta, P., Bishop, P., Zamora, M. D. Fernández, Muñoz-Bono, J., Curiel-Balsera, E., Aguilar-Alonso, E., Hinojosa, R., Gordillo-Brenes, A., Arboleda-Sánchez, J. A., Skorniakov, I., Vikulova, D., Whiteley, C., Shaikh, O., Jones, A., Ostermann, M., Forni, L., Scott, M., Sahatjian, J., Linde-Zwirble, W., Hansell, D., Laoveeravat, P., Srisawat, N., Kongwibulwut, M., Peerapornrattana, S., Suwachittanont, N., Wirotwan, T. O., Chatkaew, P., Saeyub, P., Latthaprecha, K., Tiranathanagul, K., Eiam-ong, S., Kellum, J. A., Berthelsen, R. E., Perner, A., Jensen, A. E. K., Jensen, J. U., Bestle, M. H., Gebhard, D. J., Price, J., Kennedy, C. E., Akcan-Arikan, A., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Kang, Y. R., Nakamae, M. N., Koh, I. H. J., Hamed, K., Khaled, M. M., Soliman, R. Aly, Mokhtar, M. Sherif, Seller-Pérez, G., Arias-Verdú, D., Llopar-Valdor, E., De-Diós-Chacón, I., Quesada-García, G., Herrera-Gutierrez, M. E., Hafes, R., Carroll, G., Doherty, P., Wright, C., Vera, I. G. Guerra, Ralston, M., Gemmell, M. L., MacKay, A., Black, E., Wright, C., Docking, R. I., Appleton, R., Ralston, M. R., Gemmell, L., Appleton, R., Wright, C., Docking, R. I., Black, E., Mackay, A., Rozemeijer, S., Mulier, J. L. G. Haitsma, Röttgering, J. G., Elbers, P. W. G., Spoelstra-de Man, A. M. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Mejeni, N., Nsiala, J., Kilembe, A., Akilimali, P., Thomas, G., Egerod, I., Andersson, A. E., Fagerdahl, A. M., Knudsen, V., Meddeb, K., Cheikh, A. Ben, Hamdaoui, Y., Ayachi, J., Guiga, A., Fraj, N., Romdhani, S., Sma, N., Bouneb, R., Chouchene, I., Khedher, A., Bouafia, N., Boussarsar, M., Amirian, A., Ziaian, B., Masjedi, M., Fleischmann, C., Thomas-Rueddel, D. O., Schettler, A., Schwarzkopf, D., Stacke, A., Reinhart, K., Filipe, E., Escoval, A., Martins, A., Sousa, P., Velez, N., Viegas, E., Tomas, E., Snell, G., Matsa, R., Paary, T. T. S., Kalaiselvan, M. S., Cavalheiro, A. M., Rocha, L. L., Vallone, C. S., Tonilo, A., Lobato, M. D. S., Malheiro, D. T., Sussumo, G., Lucino, N. M., Zand, F., Rosenthal, V. D., Masjedi, M., Sabetian, G., Maghsudi, B., Ghorbani, M., Dashti, A. Sanaei, Yousefipour, A., Goodall, J. R., Williamson, M., Tant, E., Thomas, N., Balci, C., Gonen, C., Haftacı, E., Gurarda, H., Karaca, E., Paldusová, B., Zýková, I., Šímová, D., Houston, S., D’Antona, L., Lloyd, J., Garnelo-Rey, V., Sosic, M., Sotosek-Tokmazic, V., Kuharic, J., Antoncic, I., Dunatov, S., Sustic, A., Chong, C. T., Sim, M., Lyovarin, T., Díaz, F. M. Acosta, Galdó, S. Narbona, Garach, M. Muñoz, Romero, O. Moreno, Bailón, A. M. Pérez, Pinel, A. Carranza, Colmenero, M., Gritsan, A., Gazenkampf, A., Korchagin, E., Dovbish, N., Lee, R. M., Lim, M. P. P., Chong, C. T., Lim, B. C. L., See, J. J., Assis, R., Filipe, F., Lopes, N., Pessoa, L., Pereira, T., Catorze, N., Aydogan, M. S., Aldasoro, C., Marchio, P., Jorda, A., Mauricio, M. D., Guerra-Ojeda, S., Gimeno-Raga, M., Colque-Cano, M., Bertomeu-Artecero, A., Aldasoro, M., Valles, S. L., Tonon, D., Triglia, T., Martin, J. C., Alessi, M. C., Bruder, N., Garrigue, P., Velly, L., Spina, S., Scaravilli, V., Marzorati, C., Colombo, E., Savo, D., Vargiolu, A., Cavenaghi, G., Citerio, G., Andrade, A. H. V., Bulgarelli, P., Araujo, J. A. P., Gonzalez, V., Souza, V. A., Costa, A., Massant, C., Filho, C. A. C. Abreu, Morbeck, R. A., Burgo, L. E., van Groenendael, R., van Eijk, L. T., Leijte, G. P., Koeneman, B., Kox, M., Pickkers, P., García-de la Torre, A., de la Torre-Prados, M., Fernández-Porcel, A., Rueda-Molina, C., Nuevo-Ortega, P., Tsvetanova-Spasova, T., Cámara-Sola, E., García-Alcántara, A., Salido-Díaz, L., Liao, X., Feng, T., Zhang, J., Cao, X., Wu, Q., Xie, Z., Li, H., Kang, Y., Winkler, M. S., Nierhaus, A., Mudersbach, E., Bauer, A., Robbe, L., Zahrte, C., Schwedhelm, E., Kluge, S., Zöllner, C., Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., Welters, I. D., Blakey, J. D., Rajam, G., Ades, E. W., Ferreira, D. M., Wang, D., Kadioglu, A., Gordon, S. B., Koch, R., Kox, M., Rahamat-Langedoen, J., Schloesser, J., de Jonge, M., Pickkers, P., Bringue, J., Guillamat-Prats, R., Torrents, E., Martinez, M. L., Camprubí-Rimblas, M., Artigas, A., Blanch, L., Park, S. Y., Park, Y. B., Song, D. K., Shrestha, S., Park, S. H., Koh, Y., Park, M. J., Hong, C. W., Lesur, O., Coquerel, D., Sainsily, X., Cote, J., Söllradl, T., Murza, A., Dumont, L., Dumaine, R., Grandbois, M., Sarret, P., Marsault, E., Salvail, D., Auger-Messier, M., Chagnon, F., Lauretta, M. P., Greco, E., Dyson, A., Singer, M., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Singer, M., Sarıca, L. Topcu, Zibandeh, N., Genc, D., Gul, F., Akkoc, T., Kombak, E., Cinel, L., Akkoc, T., Cinel, I., Pollen, S. J., Arulkumaran, N., Singer, M., Torrance, H. D., Longbottom, E. R., Warnes, G., Hinds, C. J., Pennington, D. J., Brohi, K., O’Dwyer, M. J., Kim, H. Y., Na, S., Kim, J., Chang, Y. F., Chao, A., Shih, P. Y., Lee, C. T., Yeh, Y. C., Chen, L. W., Adriaanse, M., Trogrlic, Z., Ista, E., Lingsma, H., Rietdijk, W., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., Gommers, D. A. M. P. J., van der Jagt, M., Funcke, S., Sauerlaender, S., Saugel, B., Pinnschmidt, H., Reuter, D. A., Nitzschke, R., Perbet, S., Biboulet, C., Lenoire, A., Bourdeaux, D., Pereira, B., Plaud, B., Bazin, J. E., Sautou, V., Mebazaa, A., Constantin, J. M., Legrand, M., Boyko, Y., Jennum, P., Nikolic, M., Oerding, H., Holst, R., Toft, P., Nedergaard, H. K., Haberlandt, T., Jensen, H. I., Toft, P., Park, S., Kim, S., Cho, Y. J., Lim, Y. J., Chan, A., Tang, S., Nunes, S. L., Forsberg, S., Blomqvist, H., Berggren, L., Sörberg, M., Sarapohja, T., Wickerts, C. J., Hofhuis, J. G. M., Rose, L., Blackwood, B., Akerman, E., Mcgaughey, J., Egerod, I., Fossum, M., Foss, H., Georgiou, E., Graff, H. J., Kalafati, M., Sperlinga, R., Schafer, A., Wojnicka, A. G., Spronk, P. E., Zand, F., Khalili, F., Afshari, R., Sabetian, G., Masjedi, M., Maghsudi, B., Khodaei, H. Haddad, Javadpour, S., Petramfar, P., Nasimi, S., Vazin, A., Ziaian, B., Tabei, H., Gunther, A., Hansen, J. O., Sackey, P., Storm, H., Bernhardsson, J., Sundin, Ø., Bjärtå, A., Bienert, A., Smuszkiewicz, P., Wiczling, P., Przybylowski, K., Borsuk, A., Trojanowska, I., Matysiak, J., Kokot, Z., Paterska, M., Grzeskowiak, E., Messina, A., Bonicolini, E., Colombo, D., Moro, G., Romagnoli, S., De Gaudio, A. R., Corte, F. Della, Romano, S. M., Silversides, J. A., Major, E., Mann, E. E., Ferguson, A. J., Mcauley, D. F., Marshall, J. C., Blackwood, B., Fan, E., Diaz-Rodriguez, J. A., Silva-Medina, R., Gomez-Sandoval, E., Gomez-Gonzalez, N., Soriano-Orozco, R., Gonzalez-Carrillo, P. L., Hernández-Flores, M., Pilarczyk, K., Lubarksi, J., Wendt, D., Dusse, F., Günter, J., Huschens, B., Demircioglu, E., Jakob, H., Palmaccio, A., Dell’Anna, A. M., Grieco, D. L., Torrini, F., Iaquaniello, C., Bongiovanni, F., Antonelli, M., Toscani, L., Antonakaki, D., Bastoni, D., Aya, H. D., Rhodes, A., Cecconi, M., Jozwiak, M., Depret, F., Teboul, J. L., Alphonsine, J., Lai, C., Richard, C., Monnet, X., László, I., Demeter, G., Öveges, N., Tánczos, K., Németh, M., Trásy, D., Kertmegi, I., Érces, D., Tudor, B., Kaszaki, J., Molnár, Z., Hasanin, A., Lotfy, A., El-adawy, A., Nassar, H., Mahmoud, S., Abougabal, A., Mukhtar, A., Quinty, F., Habchi, S., Luzi, A., Antok, E., Hernandez, G., Lara, B., Enberg, L., Ortega, M., Leon, P., Kripper, C., Aguilera, P., Kattan, E., Bakker, J., Huber, W., Lehmann, M., Sakka, S., Bein, B., Schmid, R. M., Preti, J., Creteur, J., Herpain, A., Marc, J., Zogheib, E., Trojette, F., Bar, S., Kontar, L., Titeca, D., Richecoeur, J., Gelee, B., Verrier, N., Mercier, R., Lorne, E., Maizel, J., Dupont, H., Slama, M., Abdelfattah, M. E., Eladawy, A., Elsayed, M. A. Ali, Mukhtar, A., Montenegro, A. Pedraza, Zepeda, E. Monares, Granillo, J. Franco, Sánchez, J. S. Aguirre, Alejo, G. Camarena, Cabrera, A. Rugerio, Montoya, A. A. Tanaka, Lee, C., Hatib, F., Cannesson, M., Theerawit, P., Morasert, T., Sutherasan, Y., Zani, G., Mescolini, S., Diamanti, M., Righetti, R., Scaramuzza, A., Papetti, M., Terenzoni, M., Gecele, C., Fusari, M., Hakim, K. A., Chaari, A., Ismail, M., Elsaka, A. H., Mahmoud, T. M., Bousselmi, K., Kauts, V., Casey, W. F., Hutchings, S. D., Naumann, D., Wendon, J., Watts, S., Kirkman, E., Jian, Z., Buddi, S., Lee, C., Settels, J., Hatib, F., Pinsky, M. R., Bertini, P., Guarracino, F., Trepte, C., Richter, P., Haas, S. A., Eichhorn, V., Kubitz, J. C., Reuter, D. A., Soliman, M. S., Hamimy, W. I., Fouad, A. Z., Mukhtar, A. M., Charlton, M., Tonks, L., Mclelland, L., Coats, T. J., Thompson, J. P., Sims, M. R., Williams, D., Roushdy, D. Z., Soliman, R. A., Nahas, R. A., Arafa, M. Y., Hung, W. T., Chiang, C. C., Huang, W. C., Lin, K. C., Lin, S. C., Cheng, C. C., Kang, P. L., Wann, S. 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W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
Published: 2016
Full Text: View/download PDF

2. Ongoing Health Care Expenditure in Survivors of Sepsis in The Intensive Care Unit

Author: Koster-Brouwer, M, van de Groep, K, Klein Klouwenberg, P, Pasma, W, van der Poll, T, Bonten, M, and Cremer, O
Published: 2015
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3. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis : A matched cohort study

Author: Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., Verboom, Diana M., Intensive Care Medicine, Center of Experimental and Molecular Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
Subjects: Male, Critical Illness, Congenital cytomegalovirus infection, Cytomegalovirus, Inflammation, Viremia, Critical Care and Intensive Care Medicine, Cohort Studies, Sepsis, 03 medical and health sciences, 0302 clinical medicine, medicine, Clinical endpoint, Host response, Humans, 030212 general & internal medicine, Critically ill, Aged, Chi-Square Distribution, Interleukin-6, business.industry, Research, Elastase, lcsh:Medical emergencies. Critical care. Intensive care. First aid, virus diseases, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Middle Aged, medicine.disease, Reactivation, Immunity, Humoral, Interleukin-10, Chemokine CXCL10, Intensive Care Units, Interleukin 1 Receptor Antagonist Protein, Cytomegalovirus Infections, Immunology, Biomarker (medicine), Female, Virus Activation, medicine.symptom, Serostatus, business, Biomarkers
Abstract: Background Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. Therefore, we studied the effects of CMV reactivation on the temporal course of host response biomarkers in patients with sepsis. Methods In this matched cohort study, each sepsis patient developing CMV reactivation between day 3 and 17 (CMV+) was compared with one CMV seropositive patient without reactivation (CMVs+) and one CMV seronegative patient (CMVs−). CMV serostatus and plasma loads were determined by enzyme-linked immunoassays and real-time polymerase chain reaction, respectively. Systemic interleukin-6 (IL-6), IL-8, IL-18, interferon-gamma–induced protein-10 (IP-10), neutrophilic elastase, IL-1 receptor antagonist (RA), and IL-10 were measured at five time points by multiplex immunoassay. The effects of CMV reactivation on sequential concentrations of these biomarkers were assessed in multivariable mixed models. Results Among 64 CMV+ patients, 45 could be matched to CMVs+ or CMVs− controls or both. The two baseline characteristics and host response biomarker levels at viremia onset were similar between groups. CMV+ patients had increased IP-10 on day 7 after viremia onset (symmetric percentage difference +44% versus −15% when compared with CMVs+ and +37% versus +4% when compared with CMVs−) and decreased IL-1RA (−41% versus 0% and −49% versus +10%, respectively). However, multivariable analyses did not show an independent association between CMV reactivation and time trends of IL-6, IP-10, IL-10, or IL-1RA. Conclusion CMV reactivation was not independently associated with changes in the temporal trends of host response biomarkers in comparison with non-reactivating patients. Therefore, these markers should not be used as surrogate clinical endpoints for interventional studies evaluating anti-CMV therapy. Electronic supplementary material The online version of this article (10.1186/s13054-018-2261-0) contains supplementary material, which is available to authorized users.
Published: 2018

4. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Author: Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, CDL Patiëntenzorg MI, Medische Staf Intensive Care, Epi Infectieziekten Team 2, JC onderzoeksprogramma Methodologie, MMB opleiding Arts microbioloog, CTI, Epi Infectieziekten, MMB, Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., Verboom, Diana M., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, CDL Patiëntenzorg MI, Medische Staf Intensive Care, Epi Infectieziekten Team 2, JC onderzoeksprogramma Methodologie, MMB opleiding Arts microbioloog, CTI, Epi Infectieziekten, MMB, Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., and Verboom, Diana M.
Published: 2018

5. ESICM LIVES 2016 : part one : Milan, Italy. 1-5 October 2016

Author: Bos, L, Schouten, L, van Vught, L, Wiewel, M, Ong, D, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A, van der Poll, T, Horn, J, Juffermans, N, Schultz, M, de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E, Bellani, G, Verboom, D, van de Groep, K, Frencken, J, Bonten, M, Fuchs, C, Schweizer, R, Costa, A, van der Jagt, M, Verbrugge, S J, Hoekstra, M, Ali, M, Janssen, N, Liao, X, de Jonge, M, Cheng, C C, Chen, C J, Chen, H L, Silva, M M M, Moolenaar, D L J, de Lange, D W, Cheng, K C, Simonis, F D, Cremer, O L, Ong, D S Y, Hall, D, van Lieshout, E J, and LUNG SAFE investigators and the ESICM study group
Subjects: Journal Article
Published: 2016

6. Sepsis 2016 Paris : Paris, France. 6-8 December 2016

Author: Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A
Published: 2016

7. ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016

Author: MMB opleiding Arts microbioloog, Infection & Immunity, Medische Staf Intensive Care, MS Nefrologie, Epi Infectieziekten Team 1, Epi Infectieziekten, MMB, JC onderzoeksprogramma Infectieziekten, Psychosociale zorg, Longziekten, Medische staf Anesthesiologie, CDL Klinisch Chemici in opleiding, MS Radiotherapie, Circulatory Health, Epi Methoden Team 2, MS Mondziekten/Kaakchirurgie, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, Ontwikkelingsstoornissen Med., Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Expertisecentrum Alg., Hubrecht Institute with UMC, Unit Opleiding Aios, MICU, CMM Groep Coffer, In Vivo NMR ISI, Bos, L, Schouten, L, van Vught, L, Wiewel, M, Ong, D, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A, van der Poll, T, Horn, J, Juffermans, N, Schultz, M, de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E, Bellani, G, Verboom, D, van de Groep, K, Frencken, J, Bonten, M, Fuchs, C, Schweizer, R, Costa, A, van der Jagt, M, Verbrugge, S J, Hoekstra, M, Ali, M, Janssen, N, Liao, X, de Jonge, M, Cheng, C C, Chen, C J, Chen, H L, Silva, M M M, Moolenaar, D L J, de Lange, D W, Cheng, K C, Simonis, F D, Cremer, O L, Ong, D S Y, Hall, D, van Lieshout, E J, LUNG SAFE investigators and the ESICM study group, MMB opleiding Arts microbioloog, Infection & Immunity, Medische Staf Intensive Care, MS Nefrologie, Epi Infectieziekten Team 1, Epi Infectieziekten, MMB, JC onderzoeksprogramma Infectieziekten, Psychosociale zorg, Longziekten, Medische staf Anesthesiologie, CDL Klinisch Chemici in opleiding, MS Radiotherapie, Circulatory Health, Epi Methoden Team 2, MS Mondziekten/Kaakchirurgie, Other research (not in main researchprogram), Cardiovasculaire Epi Team 5, Ontwikkelingsstoornissen Med., Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Expertisecentrum Alg., Hubrecht Institute with UMC, Unit Opleiding Aios, MICU, CMM Groep Coffer, In Vivo NMR ISI, Bos, L, Schouten, L, van Vught, L, Wiewel, M, Ong, D, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A, van der Poll, T, Horn, J, Juffermans, N, Schultz, M, de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E, Bellani, G, Verboom, D, van de Groep, K, Frencken, J, Bonten, M, Fuchs, C, Schweizer, R, Costa, A, van der Jagt, M, Verbrugge, S J, Hoekstra, M, Ali, M, Janssen, N, Liao, X, de Jonge, M, Cheng, C C, Chen, C J, Chen, H L, Silva, M M M, Moolenaar, D L J, de Lange, D W, Cheng, K C, Simonis, F D, Cremer, O L, Ong, D S Y, Hall, D, van Lieshout, E J, and LUNG SAFE investigators and the ESICM study group
Published: 2016

8. Sepsis 2016 Paris: Paris, France. 6-8 December 2016

Author: Epi Infectieziekten Team 1, Infection & Immunity, Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, Divisie Beeld & Oncologie, MMB, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Epi Infectieziekten Team 1, Infection & Immunity, Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, Divisie Beeld & Oncologie, MMB, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A
Published: 2016

9. Sepsis 2016 Paris

Author: Ingles, Marcia, primary, Crowfoot, Gary, additional, Smelaya, Tamara V., additional, Kuzovlev, Artem N., additional, Salnikova, Lubov E., additional, Bhikoo, Raisa, additional, Khwannimit, Bodin, additional, Bhurayanontachai, Rungsun, additional, Vattanavanit, Veerapong, additional, Tourteau, Emilie, additional, Filali, Amel, additional, van Grunderbeeck, Nicolas, additional, Nigeon, Olivier, additional, Bazus, Hélène, additional, Masse, Juliette, additional, Mallat, Jihad, additional, Thevenin, Didier, additional, Prokhorenko, Isabella, additional, Kabanov, Dmitry, additional, Zubova, Svetlana, additional, Grachev, Sergey, additional, Salcedo, Margarita, additional, Witte, Stephan, additional, Cuvier, Valérie, additional, Derive, Marc, additional, Gibot, Sébastien, additional, Garaud, Jean-Jacques, additional, Kumar, Vijay, additional, Chhibber, Sanjay, additional, Santos, Jerico R., additional, Sevillejal, Jesus Emmanuel A. D., additional, Nevado, Jose B., additional, Linge, Helena M., additional, Ochani, Kanta, additional, Lin, Ke, additional, Lee, Ji Young, additional, Wang, Ping, additional, Tembhre, Manoj, additional, Liu, Shu Fang, additional, Singhal, Pravin C., additional, Miller, Edmund J., additional, HO, Jeffery, additional, Liu, Xiaodong, additional, Kwong, Thomas, additional, Zhang, Lin, additional, Chan, Hung, additional, Wong, Sunny H., additional, Choi, Gordon, additional, Gin, Tony, additional, Chan, Matthew T. V., additional, Wu, William K. K., additional, Vliegen, Gwendolyn, additional, Kehoe, Kaat, additional, Verkerk, Robert, additional, Fransen, Erik, additional, Peters, Esther, additional, Lambeir, Anne-Marie, additional, Pickkers, Peter, additional, Jorens, Philippe G., additional, De Meester, Ingrid, additional, Ribeiro, Aline Barbosa, additional, Souza, Ana Paula Trevelin, additional, Giusti, Humberto, additional, Franci, Celso Rodrigues, additional, Saia, Rafael Simone, additional, Anderko, Renee R., additional, Jackson, Vanessa M., additional, Palmer, Octavia M. Peck, additional, Angus, Derek C., additional, Kellum, John A., additional, Carcillo, Joseph A., additional, Verboom, D. M., additional, Koster-Brouwer, M. E., additional, van de Groep, K., additional, Frencken, J. F., additional, Scicluna, B., additional, Gisbertz, S. S., additional, Henegouwen, M. I. van Berge, additional, Ruurda, J. P., additional, van Hillegersberg, R., additional, van der Poll, T., additional, Bonten, M. J. M., additional, Cremer, O. L., additional, Klouwenberg, P. M. C. Klein, additional, Beloborodova, Natalia, additional, Osipov, Artem, additional, Pautova, Alisa, additional, Bedova, Aleksandra, additional, Mas-Oliva, Jaime, additional, García-González, Victor, additional, Sukhina, Marina, additional, Zhukhovitskiy, Vladimir, additional, Sukhina, Marina A., additional, Obraztsov, Igor, additional, Zhukhovitskiy, Vladimir G., additional, Peronace, Cinzia, additional, Matera, Giovanni, additional, Galati, Luisa, additional, Giancotti, Aida, additional, Barreca, Giorgio Settimo, additional, Quirino, Angela, additional, Liberto, Maria Carla, additional, Focà, Alfredo, additional, Labiad, Yasmine, additional, Venton, Geoffroy, additional, Baier, Céline, additional, Colle, Julien, additional, Farnault, Laure, additional, Brunet, Corinne, additional, Loriod, Béatrice, additional, Fernandez-Nunez, Nicloas, additional, Suchon, Pierre, additional, Mattei, Jean-Camille, additional, Rihet, Pascal, additional, Nguyen, Catherine, additional, Costello, Régis, additional, Tesfai, Abel, additional, Ahmetaj-Shala, Blerina, additional, Gashaw, Hime, additional, Quinlan, Gregory, additional, MacCallum, Niall, additional, Mumby, Sharon, additional, Gray, DNicola, additional, Leiper, James, additional, Kirkby, Nicholas, additional, Mitchell, Jane A., additional, Costa, Luis Henrique A., additional, Catalão, Carlos Henrique R., additional, Santos-Júnior, Nilton N., additional, Souza, Anderson O., additional, Alberici, Luciane C., additional, and Rocha, Maria José A., additional
Published: 2016
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10. Social position of adolescents with chronic digestive disorders

Author: Calsbeek, Hiske, Rijken, Mieke, Bekkers, Marc J.T.M., Kerssens, Jan J., Dekker, Joost, Van Berge Henegouwen, Gerard P., Hopman, W., Jansen, J. B.M.J., Severijnen, R. S.V.M., Tolboom, J. J.M., Bergmeijer, J. H.L.J., Van Buuren, H. R., Dees, J., Gerth van Wijk, R., De Groot, H., Sinaasappel, M., Bruijnzeel-Koomen, C. A.F.M., Van Hattum, J., Houwen, R. H.J., Knulst, A. C., Oldenburg, B., Sinnema, G., Cooreman, M. P.R., Derkx, H. H.F., Van Deventer, S. J.H., Loonen, H. J., Rauws, E. A.J., Bijleveld, Ch M.A., Jansen, P. L.M., De Monchy, J. G.R., Van de Groep, K., Schalekamp, G., Hesselink-van de Kruijs, M., Russel, M. G.V.M., Mearin Manrique, M., Mulder, C. J.J., Verhage, J., Phaff, R. A.S., Gijsbers, C. F.M., Van Ditshuijsen, Th J.M., Rehabilitation medicine, APH - Aging & Later Life, APH - Mental Health, CCA - Cancer Treatment and quality of life, and Gastroenterology and hepatology
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Digestive System Diseases, Population, Disease, Social class, Quality of life (healthcare), Surveys and Questionnaires, Digestive disorder, medicine, Humans, Social position, Social Behavior, education, Psychiatry, education.field_of_study, Hepatology, business.industry, Gastroenterology, Cross-Sectional Studies, Social Class, Socioeconomic Factors, Case-Control Studies, Chronic Disease, Immunology, Female, business, Social status
Abstract: Objective To investigate the consequences of having a chronic digestive disorder on the social position of adolescents. Methods Five diagnostic groups, including inflammatory bowel disease (I BID), chronic liver diseases, congenital digestive disorders, coeliac disease and food allergy (total n = 758, ages 12-25 years), were each compared with a population-based control group in a multicentre study using a cross-sectional design. Social position was assessed by a mailed questionnaire measuring 24 aspects, categorized as education, leisure activities, friendship, labour participation, financial situation, partnership and sexuality. Results Eight aspects of social position were found to be affected negatively by one or more chronic digestive diseases: absence from school due to illness, going out, having a paid job, needing re-education in order to get a job, getting benefits as main income source, encountering bottlenecks in establishing financial commitments, having self-confidence in making a pass at someone, and restrictions in making love. Adolescents with chronic liver disease and IBD were found to experience more restrictions in social position. Adolescents with food allergy and congenital digestive disorders appear to experience some restrictions, but to a lesser degree, and adolescents with coeliac disease do not appear to have any problems regarding social position compared with controls. Conclusion The social position of adolescents is affected negatively by having a chronic digestive disease, in particular chronic liver disease and IBD. Negative consequences occur in education, leisure activities, labour participation, financial situation, partnership and sexuality. (C) 2002 Lippincott Williams Wilkins.
Published: 2002
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11. Sepsis 2016 Paris

Author: Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean-Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A. D., Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T. V., Wu, William K. K., Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne-Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M. Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I. van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J. M., Cremer, O. L., Klouwenberg, P. M. C. Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean-Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola, Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A., Catalão, Carlos Henrique R., Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A.
Subjects: Critical Care and Intensive Care Medicine, Meeting Abstracts
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12. Etiology of Myocardial Injury in Critically Ill Patients with Sepsis: A Cohort Study.

Author: Frencken JF, van Smeden M, van de Groep K, Ong DSY, Klein Klouwenberg PMC, Juffermans N, Bonten MJM, van der Poll T, and Cremer OL
Subjects: Biomarkers, Cohort Studies, Critical Illness, Humans, Inflammation, Intensive Care Units, Troponin I, Heart Injuries etiology, Sepsis complications
Abstract: Rationale: Myocardial injury occurs frequently during sepsis and is independently associated with mortality. However, its etiology remains largely unknown. Objectives: To assess the relative contributions of hyperinflammation, activated coagulation, and endothelial dysfunction to myocardial injury in critically ill patients with sepsis. Methods: We included consecutive patients with sepsis presenting to two tertiary intensive care units in the Netherlands between 2011 and 2013. High-sensitivity cardiac troponin I as well as a wide range of plasma biomarkers related to inflammation, coagulation, and endothelial function were measured. Structural equation modeling was used to construct latent variables representing each of these pathophysiological constructs and to subsequently study their associations with troponin elevation while adjusting for confounders. Results: We analyzed 908 (88%) of 1,037 eligible patients, 553 (61%) of whom had raised high-sensitivity cardiac troponin I levels upon intensive care unit admission. The latent variables included interleukin (IL)-6, IL-8, and IL-1β for inflammation; platelet count, prothrombin time, and protein C for coagulation; and soluble E-selectin, intercellular adhesion molecule-1, and angiopoietin-2 for endothelial function. After adjustment for age and cardiovascular comorbidities, structural equation modeling analysis showed that activated coagulation was independently associated with elevated troponin during sepsis (standardized regression coefficient, 0.551; 95% confidence interval [CI], 0.257-0.845; P < 0.001) whereas hyperinflammation and endothelial dysfunction were not (standardized regression coefficient, -0.161; 95% CI, -0.418 to 0.096 and -0.054; 95% CI, -0.168 to 0.060, respectively). Conclusions: Our findings suggest that myocardial injury during sepsis is mediated by systemic activation of coagulation rather than by circulating inflammatory mediators or activation of the endothelium. These findings may guide evaluation of strategies to protect the myocardium during sepsis. Clinical trial registered with clinicaltrials.gov (NCT01905033).
Published: 2022
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13. The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.

Author: Verboom DM, van de Groep K, Boel CHE, Haas PJA, Derde LPG, Cremer OL, and Bonten MJM
Subjects: Aged, Female, Humans, Intensive Care Units statistics & numerical data, Male, Middle Aged, Patient Admission, Prospective Studies, Sepsis blood, Sepsis diagnosis, Blood Culture methods, Blood Culture statistics & numerical data, Critical Illness therapy, Sepsis microbiology
Abstract: Objectives: Although the Surviving Sepsis Campaign bundle recommends obtaining blood cultures within 1 hour of sepsis recognition, adherence is suboptimal in many settings. We, therefore, implemented routine blood culture collection for all nonelective ICU admissions (regardless of infection suspicion) and evaluated its diagnostic yield., Design: A before-after analysis., Setting: A mixed-ICU of a tertiary care hospital in the Netherlands., Patients: Patients acutely admitted to the ICU between January 2015 and December 2018., Measurements and Main Results: Automatic orders for collecting a single set of blood cultures immediately upon ICU admission were implemented on January 1, 2017. Blood culture results and the impact of contaminated blood cultures were compared for 2015-2016 (before period) and 2017-2018 (after period). Positive blood cultures were categorized as bloodstream infection or contamination. Blood cultures were obtained in 573 of 1,775 patients (32.3%) and in 1,582 of 1,871 patients (84.5%) in the before and after periods, respectively (p < 0.0001), and bloodstream infection was diagnosed in 95 patients (5.4%) and 154 patients (8.2%) in both study periods (relative risk 1.5; 95% CI 1.2-2.0; p = 0.0006). The estimated number needed to culture for one additional patient with bloodstream infection was 17. Blood culture contamination occurred in 40 patients (2.3%) and 180 patients (9.6%) in the before period and after period, respectively (relative risk 4.3; 95% CI 3.0-6.0; p < 0.0001). Rate of vancomycin use or presumed episodes of catheter-related bloodstream infections treated with antibiotics did not differ between both study periods., Conclusions: Implementation of routine blood cultures was associated with a 1.5-fold increase of detected bloodstream infection. The 4.3-fold increase in contaminated blood cultures was not associated with an increase in vancomycin use in the ICU., Competing Interests: Dr. Verboom’s and Bonten’s institutions received funding from the Innovative Medicine Initiative, European Union’s Seventh Framework Programme (FP7/2007–2013), and European Federation of Pharmaceutical Industries and Associations companies’ in-kind contribution (Combatting Bacterial resistance in Europe-Carbapenem-Resistance, grant agreement 115 620). The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2020 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.)
Published: 2021
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14. Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill.

Author: Boshuizen M, Binnekade JM, Nota B, van de Groep K, Cremer OL, Horn J, Schultz MJ, van Bruggen R, and Juffermans NP
Abstract: Background: Anemia of inflammation (AI) is the most common cause of anemia in the critically ill, but its diagnosis is a challenge. New therapies specific to AI are in development, and they require accurate detection of AI. This study explores the potential of parameters of iron metabolism for the diagnosis of AI during an ICU stay., Methods: In a nested case-control study, 30 patients developing AI were matched to 60 controls. The iron parameters were determined in plasma samples during an ICU stay. Receiver operating characteristic curves were used to determine the iron parameter threshold with the highest sensitivity and specificity to predict AI. Likelihood ratios as well as positive and negative predictive values were calculated as well., Results: The sensitivity of iron parameters for diagnosing AI ranges between 62 and 76%, and the specificity between 57 and 72%. Iron and transferrin show the greatest area under the curve. Iron shows the highest sensitivity, and transferrin and transferrin saturation display the highest specificity. Hepcidin and ferritin show the lowest specificity. At an actual anemia prevalence of 53%, the diagnostic accuracy of iron, transferrin, and transferrin saturation was fair, with a positive predictive value between 71 and 73%. Combining iron, transferrin, transferrin saturation, hepcidin, and/or ferritin levels did not increase the accuracy of the AI diagnosis., Conclusions: In this explorative study on the use of different parameters of iron metabolism for diagnosing AI during an ICU stay, low levels of commonly measured markers such as plasma iron, transferrin, and transferrin saturation have the highest sensitivity and specificity and outperform ferritin and hepcidin., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2019 by S. Karger AG, Basel.)
Published: 2020
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15. Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis.

Author: van de Groep K, Bos MP, Varkila MRJ, Savelkoul PHM, Ong DSY, Derde LPG, Juffermans NP, van der Poll T, Bonten MJM, and Cremer OL
Subjects: Aged, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Blood microbiology, Critical Illness, Multiplex Polymerase Chain Reaction methods, Real-Time Polymerase Chain Reaction methods, Sepsis diagnosis
Abstract: A novel multiplex real-time PCR for bloodstream infections (BSI-PCR) detects pathogens directly in blood. This study aimed at determining the positive predictive value (PPV) of BSI-PCR in critically ill patients with sepsis. We included consecutive patients with presumed sepsis upon admission to the intensive care unit (ICU). The multiplexed BSI-PCR included 17 individual PCRs for a broad panel of species- and genus-specific DNA targets. BSI-PCR results were compared with a reference diagnosis for which plausibility of infection and causative pathogen(s) had been prospectively assessed by trained observers, based on available clinical and microbiological evidence. PPV and false positive proportion (FPP) were calculated. Clinical plausibility of discordant positive results was adjudicated by an expert panel. Among 325 patients, infection likelihood was categorized as confirmed, uncertain, and ruled out in 210 (65%), 88 (27%), and 27 (8%) subjects, respectively. BSI-PCR identified one or more microorganisms in 169 (52%) patients, of whom 104 (61%) had at least one detection in accordance with the reference diagnosis. Discordant positive PCR results were observed in 95 patients, including 30 subjects categorized as having an "unknown" pathogen. Based on 5525 individual PCRs yielding 295 positive results, PPV was 167/295 (57%) and FPP was 128/5525 (2%). Expert adjudication of the 128 discordant PCR findings resulted in an adjusted PPV of 68% and FPP of 2%. BSI-PCR was all-negative in 156 patients, including 79 (51%) patients in whom infection was considered ruled out. BSI-PCR may complement conventional cultures and expedite the microbiological diagnosis of sepsis in ICU patients, but improvements in positive predictive value of the test are warranted before its implementation in clinical practice can be considered.
Published: 2019
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16. Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: The Role of Plasma Galactomannan.

Author: van de Groep K, Verboom DM, van de Veerdonk FL, Haas PA, van der Poll T, Schultz MJ, Bonten MJM, and Cremer OL
Subjects: Female, Galactose analogs & derivatives, Humans, Male, Biomarkers blood, Critical Illness, Influenza, Human complications, Influenza, Human physiopathology, Invasive Pulmonary Aspergillosis diagnosis, Invasive Pulmonary Aspergillosis etiology, Mannans blood
Published: 2019
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17. Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection.

Author: van de Groep K, Verhoeff TL, Verboom DM, Bos LD, Schultz MJ, Bonten MJM, and Cremer OL
Subjects: Aged, Anti-Bacterial Agents therapeutic use, Critical Illness, Cross-Sectional Studies, Female, Humans, Intensive Care Units, Male, Middle Aged, Netherlands, Retrospective Studies, Critical Care, Cross Infection prevention & control, Intraabdominal Infections prevention & control
Abstract: Purpose: To describe the characteristics and procedural outcomes of source control interventions among Intensive Care Unit (ICU) patients with severe intra-abdominal-infection (IAI)., Material and Methods: We identified consecutive patients with suspected IAI in whom a source control intervention had been performed in two tertiary ICUs in the Netherlands, and performed retrospective in-depth case reviews to evaluate procedure type, diagnostic yield, and adequacy of source control after 14 days., Results: A total of 785 procedures were observed among 353 patients, with initial interventions involving 266 (75%) surgical versus 87 (25%) percutaneous approaches. Surgical index procedures typically involved IAI of (presumed) gastrointestinal origin (72%), whereas percutaneous index procedures were mostly performed for infections of the biliary tract/pancreas (50%) or peritoneal cavity (33%). Overall, 178 (50%) patients required multiple interventions (median 3 (IQR 2-4)). In a subgroup of 236 patients having their first procedure upon ICU admission, effective source control was ultimately achieved for 159 (67%) subjects. Persistence of organ failure was associated with inadequacy of source control at day 14, whereas trends in inflammatory markers were non-predictive., Conclusions: Approximately half of ICU patients with IAI require more than one intervention, yet successful source control is eventually achieved in a majority of cases., (Copyright © 2019 Elsevier Inc. All rights reserved.)
Published: 2019
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18. Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis.

Author: van de Groep K, Bos MP, Savelkoul PHM, Rubenjan A, Gazenbeek C, Melchers WJG, van der Poll T, Juffermans NP, Ong DSY, Bonten MJM, and Cremer OL
Subjects: Candida classification, Candida genetics, Critical Illness, Gram-Negative Bacteria classification, Gram-Negative Bacteria genetics, Gram-Positive Bacteria classification, Gram-Positive Bacteria genetics, Humans, Sensitivity and Specificity, Sepsis microbiology, Candida isolation & purification, DNA, Bacterial genetics, Gram-Negative Bacteria isolation & purification, Gram-Positive Bacteria isolation & purification, Multiplex Polymerase Chain Reaction methods, Real-Time Polymerase Chain Reaction methods, Sepsis diagnosis
Abstract: Molecular tests may enable early adjustment of antimicrobial therapy and be complementary to blood culture (BC) which has imperfect sensitivity in critically ill patients. We evaluated a novel multiplex real-time PCR assay to diagnose bloodstream pathogens directly in whole blood samples (BSI-PCR). BSI-PCR included 11 species- and four genus-specific PCRs, a molecular Gram-stain PCR, and two antibiotic resistance markers. We collected 5 mL blood from critically ill patients simultaneously with clinically indicated BC. Microbial DNA was isolated using the Polaris method followed by automated DNA extraction. Sensitivity and specificity were calculated using BC as reference. BSI-PCR was evaluated in 347 BC-positive samples (representing up to 50 instances of each pathogen covered by the test) and 200 BC-negative samples. Bacterial species-specific PCR sensitivities ranged from 65 to 100%. Sensitivity was 26% for the Gram-positive PCR, 32% for the Gram-negative PCR, and ranged 0 to 7% for yeast PCRs. Yeast detection was improved to 40% in a smaller set-up. There was no overall association between BSI-PCR sensitivity and time-to-positivity of BC (which was highly variable), yet Ct-values were lower for true-positive versus false-positive PCR results. False-positive results were observed in 84 (4%) of the 2200 species-specific PCRs in 200 culture-negative samples, and ranged from 0 to 6% for generic PCRs. Sensitivity of BSI-PCR was promising for individual bacterial pathogens, but still insufficient for yeasts and generic PCRs. Further development of BSI-PCR will focus on improving sensitivity by increasing input volumes and on subsequent implementation as a bedside test.
Published: 2018
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19. Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas.

Author: Lapek JD Jr, Mills RH, Wozniak JM, Campeau A, Fang RH, Wei X, van de Groep K, Perez-Lopez A, van Sorge NM, Raffatellu M, Knight R, Zhang L, and Gonzalez DJ
Subjects: Animals, Bacterial Proteins metabolism, Mice, Mice, Inbred C57BL, Organ Specificity, Pharyngitis microbiology, Protein Interaction Maps immunology, Proteome metabolism, Sepsis microbiology, Streptococcal Infections microbiology, Streptococcus genetics, Streptococcus immunology, Streptococcus pathogenicity, Streptococcus pyogenes metabolism, Tandem Mass Spectrometry, Host-Pathogen Interactions immunology, Proteomics methods, Streptococcal Infections immunology
Abstract: Group A Streptococcus (GAS) remains one of the top 10 deadliest human pathogens worldwide despite its sensitivity to penicillin. Although the most common GAS infection is pharyngitis (strep throat), it also causes life-threatening systemic infections. A series of complex networks between host and pathogen drive invasive infections, which have not been comprehensively mapped. Attempting to map these interactions, we examined organ-level protein dynamics using a mouse model of systemic GAS infection. We quantified over 11,000 proteins, defining organ-specific markers for all analyzed tissues. From this analysis, an atlas of dynamically regulated proteins and pathways was constructed. Through statistical methods, we narrowed organ-specific markers of infection to 34 from the defined atlas. We show these markers are trackable in blood of infected mice, and a subset has been observed in plasma samples from GAS-infected clinical patients. This proteomics-based strategy provides insight into host defense responses, establishes potentially useful targets for therapeutic intervention, and presents biomarkers for determining affected organs during bacterial infection., (Copyright © 2018 Elsevier Inc. All rights reserved.)
Published: 2018
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20. Iron metabolism in critically ill patients developing anemia of inflammation: a case control study.

Author: Boshuizen M, Binnekade JM, Nota B, van de Groep K, Cremer OL, Tuinman PR, Horn J, Schultz MJ, van Bruggen R, and Juffermans NP
Abstract: Background: Anemia occurring as a result of inflammatory processes (anemia of inflammation, AI) has a high prevalence in critically ill patients. Knowledge on changes in iron metabolism during the course of AI is limited, hampering the development of strategies to counteract AI. This case control study aimed to investigate iron metabolism during the development of AI in critically ill patients., Methods: Iron metabolism in 30 patients who developed AI during ICU stay was compared with 30 septic patients with a high Hb and 30 non-septic patients with a high Hb. Patients were matched on age and sex. Longitudinally collected plasma samples were analyzed for levels of parameters of iron metabolism. A linear mixed model was used to assess the predictive values of the parameters., Results: In patients with AI, levels of iron, transferrin and transferrin saturation showed an early decrease compared to controls with a high Hb, already prior to the development of anemia. Ferritin, hepcidin and IL-6 levels were increased in AI compared to controls. During AI development, erythroferrone decreased. Differences in iron metabolism between groups were not influenced by APACHE IV score., Conclusions: The results show that in critically ill patients with AI, iron metabolism is already altered prior to the development of anemia. Levels of iron regulators in AI differ from septic controls with a high Hb, irrespective of disease severity. AI is characterized by high levels of hepcidin, ferritin and IL-6 and low levels of iron, transferrin and erythroferrone.
Published: 2018
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21. Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

Author: Koster-Brouwer ME, Verboom DM, Scicluna BP, van de Groep K, Frencken JF, Janssen D, Schuurman R, Schultz MJ, van der Poll T, Bonten MJM, and Cremer OL
Subjects: Acute Disease, Aged, Biomarkers, Cohort Studies, Female, Humans, Infections complications, Male, Reproducibility of Results, Respiratory Insufficiency etiology, Risk Assessment, Transcriptome, Infections diagnosis, Intensive Care Units, Respiratory Insufficiency diagnosis
Abstract: Objectives: Discrimination between infectious and noninfectious causes of acute respiratory failure is difficult in patients admitted to the ICU after a period of hospitalization. Using a novel biomarker test (SeptiCyte LAB), we aimed to distinguish between infection and inflammation in this population., Design: Nested cohort study., Setting: Two tertiary mixed ICUs in the Netherlands., Patients: Hospitalized patients with acute respiratory failure requiring mechanical ventilation upon ICU admission from 2011 to 2013. Patients having an established infection diagnosis or an evidently noninfectious reason for intubation were excluded., Interventions: None., Measurement and Main Results: Blood samples were collected upon ICU admission. Test results were categorized into four probability bands (higher bands indicating higher infection probability) and compared with the infection plausibility as rated by post hoc assessment using strict definitions. Of 467 included patients, 373 (80%) were treated for a suspected infection at admission. Infection plausibility was classified as ruled out, undetermined, or confirmed in 135 (29%), 135 (29%), and 197 (42%) patients, respectively. Test results correlated with infection plausibility (Spearman's rho 0.332; p < 0.001). After exclusion of undetermined cases, positive predictive values were 29%, 54%, and 76% for probability bands 2, 3, and 4, respectively, whereas the negative predictive value for band 1 was 76%. Diagnostic discrimination of SeptiCyte LAB and C-reactive protein was similar (p = 0.919)., Conclusions: Among hospitalized patients admitted to the ICU with clinical uncertainty regarding the etiology of acute respiratory failure, the diagnostic value of SeptiCyte LAB was limited.
Published: 2018
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22. Associations Between Enteral Colonization With Gram-Negative Bacteria and Intensive Care Unit-Acquired Infections and Colonization of the Respiratory Tract.

Author: Frencken JF, Wittekamp BHJ, Plantinga NL, Spitoni C, van de Groep K, Cremer OL, and Bonten MJM
Subjects: Aged, Anti-Bacterial Agents therapeutic use, Critical Illness, Cross Infection epidemiology, Drug Resistance, Bacterial, Female, Gram-Negative Bacteria drug effects, Gram-Negative Bacteria isolation & purification, Gram-Negative Bacterial Infections epidemiology, Humans, Intensive Care Units, Male, Middle Aged, Netherlands, Prospective Studies, Rectum microbiology, Regression Analysis, Respiratory Tract Infections microbiology, Risk Factors, Bacteremia etiology, Bacterial Translocation, Cross Infection microbiology, Gastrointestinal Tract microbiology, Gram-Negative Bacteria pathogenicity, Respiratory System microbiology
Abstract: Background: Enteral and respiratory tract colonization with gram-negative bacteria may lead to subsequent infections in critically ill patients. We aimed to clarify the interdependence between gut and respiratory tract colonization and their associations with intensive care unit (ICU)-acquired infections in patients receiving selective digestive tract decontamination (SDD)., Methods: Colonization status of the rectum and respiratory tract was determined using twice-weekly microbiological surveillance in mechanically ventilated subjects receiving SDD between May 2011 and June 2015 in a tertiary medical-surgical ICU in the Netherlands. Acquisition of infections was monitored daily by dedicated observers. Marginal structural models were used to determine the associations between gram-negative rectal colonization and respiratory tract colonization, ICU-acquired gram-negative infection, and ICU-acquired gram-negative bacteremia., Results: Among 2066 ICU admissions, 1157 (56.0%) ever had documented gram-negative carriage in the rectum during ICU stay. Cumulative incidences of ICU-acquired gram-negative infection and bacteremia were 6.0% (n = 124) and 2.1% (n = 44), respectively. Rectal colonization was an independent risk factor for both respiratory tract colonization (cause-specific hazard ratio [CSHR], 2.93 [95% confidence interval {CI}, 2.02-4.23]) and new gram-negative infection in the ICU (CSHR, 3.04 [95% CI, 1.99-4.65]). Both rectal and respiratory tract colonization were associated with bacteremia (CSHR, 7.37 [95% CI, 3.25-16.68] and 2.56 [95% CI, 1.09-6.03], respectively). Similar associations were observed when Enterobacteriaceae and glucose nonfermenting gram-negative bacteria were analyzed separately., Conclusions: Gram-negative rectal colonization tends to be stronger associated with subsequent ICU-acquired gram-negative infections than gram-negative respiratory tract colonization. Gram-negative rectal colonization seems hardly associated with subsequent ICU-acquired gram-negative respiratory tract colonization., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Published: 2018
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23. Chronic healthcare expenditure in survivors of sepsis in the intensive care unit.

Author: Koster-Brouwer ME, van de Groep K, Pasma W, Smeets HM, Slooter AJC, de Lange DW, van Dijk D, van der Poll T, Bonten MJM, and Cremer OL
Subjects: Humans, Netherlands, Prospective Studies, Surveys and Questionnaires, Health Care Costs, Intensive Care Units economics, Sepsis economics, Survivors statistics & numerical data
Published: 2016
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24. Dried Saliva Spots: A Robust Method for Detecting Streptococcus pneumoniae Carriage by PCR.

Author: Krone CL, Oja AE, van de Groep K, Sanders EA, Bogaert D, and Trzciński K
Subjects: Child, DNA, Bacterial genetics, Desiccation, Humans, Population Surveillance, Real-Time Polymerase Chain Reaction, Saliva chemistry, Streptococcus pneumoniae genetics, Carrier State diagnosis, Saliva microbiology, Specimen Handling methods, Streptococcus pneumoniae isolation & purification
Abstract: The earliest studies in the late 19th century on Streptococcus pneumoniae (S. pneumoniae) carriage used saliva as the primary specimen. However, interest in saliva declined after the sensitive mouse inoculation method was replaced by conventional culture, which made isolation of pneumococci from the highly polymicrobial oral cavity virtually impossible. Here, we tested the feasibility of using dried saliva spots (DSS) for studies on pneumococcal carriage. Saliva samples from children and pneumococcus-spiked saliva samples from healthy adults were applied to paper, dried, and stored, with and without desiccant, at temperatures ranging from -20 to 37 °C for up to 35 days. DNA extracted from DSS was tested with quantitative-PCR (qPCR) specifically for S. pneumoniae. When processed immediately after drying, the quantity of pneumococcal DNA detected in spiked DSS from adults matched the levels in freshly spiked raw saliva. Furthermore, pneumococcal DNA was stable in DSS stored with desiccant for up to one month over a broad range of temperatures. There were no differences in the results when spiking saliva with varied pneumococcal strains. The collection of saliva can be a particularly useful in surveillance studies conducted in remote settings, as it does not require trained personnel, and DSS are resilient to various transportation conditions.
Published: 2016
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25. Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.

Author: Krone CL, van de Groep K, Trzciński K, Sanders EA, and Bogaert D
Subjects: Age Factors, Aged, Global Health, Humans, Immunocompetence, Incidence, Netherlands epidemiology, Pneumonia, Pneumococcal diagnosis, Population Surveillance, Respiratory Tract Infections epidemiology, Respiratory Tract Infections immunology, Risk Factors, Aging immunology, Host-Pathogen Interactions immunology, Pneumonia, Pneumococcal epidemiology, Pneumonia, Pneumococcal immunology, Streptococcus pneumoniae pathogenicity
Abstract: Respiratory infections are among the most important causes of morbidity and mortality from infectious diseases worldwide. The most common causative bacterium, Streptococcus pneumoniae, frequently colonises the upper respiratory tract, where it resides mostly asymptomatically. Occasionally, however, S pneumoniae can cause severe disease such as pneumonia. Local host immunity is essential to control colonising pathogens by preventing overgrowth, spread, and invasion. However, age-related immune deficits in elderly people, known as immunosenescence, might contribute to increased disease burden. We review present knowledge about immunosenescence in the respiratory tract against Gram-positive bacteria, particularly S pneumoniae. We discuss the possible underdetection of pneumococcal colonisation in elderly people, and suggest changes to present surveillance methods to improve understanding of the relation between colonisation and disease. We conclude that present knowledge about alteration of host-pathogen interactions by immunosenescence in the respiratory tract is insufficient, and that research is needed to enable improved measures for prevention., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Published: 2014
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25 results on '"van de Groep, K"'

1. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

2. Ongoing Health Care Expenditure in Survivors of Sepsis in The Intensive Care Unit

3. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis : A matched cohort study

4. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

5. ESICM LIVES 2016 : part one : Milan, Italy. 1-5 October 2016

6. Sepsis 2016 Paris : Paris, France. 6-8 December 2016

7. ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016

8. Sepsis 2016 Paris: Paris, France. 6-8 December 2016

9. Sepsis 2016 Paris

10. Social position of adolescents with chronic digestive disorders

11. Sepsis 2016 Paris

12. Etiology of Myocardial Injury in Critically Ill Patients with Sepsis: A Cohort Study.

13. The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.

14. Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill.

15. Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis.

16. Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: The Role of Plasma Galactomannan.

17. Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection.

18. Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis.

19. Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas.

20. Iron metabolism in critically ill patients developing anemia of inflammation: a case control study.

21. Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

22. Associations Between Enteral Colonization With Gram-Negative Bacteria and Intensive Care Unit-Acquired Infections and Colonization of the Respiratory Tract.

23. Chronic healthcare expenditure in survivors of sepsis in the intensive care unit.

24. Dried Saliva Spots: A Robust Method for Detecting Streptococcus pneumoniae Carriage by PCR.

25. Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.

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