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195 results on '"van Werkhoven, Jacob M"'

1. Superior Risk Stratification With Coronary Computed Tomography Angiography Using a Comprehensive Atherosclerotic Risk Score

Author

van Rosendael, Alexander R, Shaw, Leslee J, Xie, Joe X, Dimitriu-Leen, Aukelien C, Smit, Jeff M, Scholte, Arthur J, van Werkhoven, Jacob M, Callister, Tracy Q, DeLago, Augustin, Berman, Daniel S, Hadamitzky, Martin, Hausleiter, Jeorg, Al-Mallah, Mouaz H, Budoff, Matthew J, Kaufmann, Philipp A, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd C, Kim, Yong-Jin, Feuchtner, Gudrun, Lin, Fay Y, Jones, Erica C, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Dunning, Allison, Gomez, Millie, Hindoyan, Niree, Gransar, Heidi, Leipsic, Jonathon, Narula, Jagat, Min, James K, and Bax, Jeroen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease, Atherosclerosis, Biomedical Imaging, Prevention, Patient Safety, Cardiovascular, Clinical Research, Heart Disease - Coronary Heart Disease, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Adult, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Coronary Vessels, Female, Humans, Male, Middle Aged, Multidetector Computed Tomography, Myocardial Infarction, Plaque, Atherosclerotic, Predictive Value of Tests, Progression-Free Survival, Reproducibility of Results, Risk Assessment, Risk Factors, Severity of Illness Index, coronary computed tomography angiography, risk stratification, stable coronary artery disease, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThis study was designed to assess the prognostic value of a new comprehensive coronary computed tomography angiography (CTA) score compared with the stenosis severity component of the Coronary Artery Disease-Reporting and Data System (CAD-RADS).BackgroundCurrent risk assessment with coronary CTA is mainly focused on maximal stenosis severity. Integration of plaque extent, location, and composition in a comprehensive model may improve risk stratification.MethodsA total of 2,134 patients with suspected but without known CAD were included. The predictive value of the comprehensive CTA score (ranging from 0 to 42 and divided into 3 groups: 0 to 5, 6 to 20, and >20) was compared with the CAD-RADS combined into 3 groups (0% to 30%, 30% to 70% and ≥70% stenosis). Its predictive performance was internally and externally validated (using the 5-year follow-up dataset of the CONFIRM [Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry], n = 1,971).ResultsThe mean age of patients was 55 ± 13 years, mean follow-up 3.6 ± 2.8 years, and 130 events (myocardial infarction or death) occurred. The new, comprehensive CTA score showed strong and independent predictive value using the Cox proportional hazard analysis. A model including clinical variables plus comprehensive CTA score showed better discrimination of events compared with a model consisting of clinical variables plus CAD-RADS (0.768 vs. 0.742, p = 0.001). Also, the comprehensive CTA score correctly reclassified a significant proportion of patients compared with the CAD-RADS (net reclassification improvement 12.4%, p < 0.001). Good predictive accuracy was reproduced in the external validation cohort.ConclusionsThe new comprehensive CTA score provides better discrimination and reclassification of events compared with the CAD-RADS score based on stenosis severity only. The score retained similar prognostic accuracy when externally validated. Anatomic risk scores can be improved with the addition of extent, location, and compositional measures of atherosclerotic plaque. (Comprehensive CTA risk score calculator is available at: http://18.224.14.19/calcApp/).

Published
2019

3. Diagnostic and Prognostic Value

Author

Schuijf, Joanne D., van Werkhoven, Jacob M., J. Bax, Jeroen, van der E. Wall, Ernst, Cademartiri, Filippo, editor, Casolo, Giancarlo, editor, and Midiri, Massimo, editor

Published
2012
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10. Assessment With Multi-Slice Computed Tomography and Gray-Scale and Virtual Histology Intravascular Ultrasound of Gender-Specific Differences in Extent and Composition of Coronary Atherosclerotic Plaques in Relation to Age

Author

Pundziute, Gabija, Schuijf, Joanne D., van Velzen, Joella E., Jukema, J. Wouter, van Werkhoven, Jacob M., Nucifora, Gaetano, van der Kley, Frank, Kroft, Lucia J., de Roos, Albert, Boersma, Eric, Reiber, Johan H.C., Schalij, Martin J., van der Wall, Ernst E., and Bax, Jeroen J.

Published
2010
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20. Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation

Author

Nucifora, Gaetano, Schuijf, Joanne D., van Werkhoven, Jacob M., Trines, Serge A., Kajander, Sami, Tops, Laurens F., Turta, Olli, Jukema, J. Wouter, Schreur, Joop H. M., Heijenbrok, Mark W., Gaemperli, Oliver, Kaufmann, Philipp A., Knuuti, Juhani, van der Wall, Ernst E., Schalij, Martin J., and Bax, Jeroen J.

Published
2011
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34. Superior risk stratification with coronary CTA using a comprehensive atherosclerotic risk score

Author

van Rosendael, Alexander R., Shaw, Leslee J., Xie, Joe X., Dimitriu-Leen, Aukelien C., Smit, Jeff M., Scholte, Arthur J., van Werkhoven, Jacob M., Callister, Tracey Q., DeLago, Augustin, Berman, Daniel S., Hadamitzky, Martin, Hausleiter, Jeorg, Al-Mallah, Mouaz H., Budoff, Matthew J., Kaufmann, Philipp A., Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd C., Yong-Jin, Kim, Feuchtner, Gudrun, Lin, Fay Y., Jones, Erica C., Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Dunning, Allison, Gomez, Millie, Hindoyan, Niree, Gransar, Heidi, Leipsic, Jonathon, Narula, Jagat, Min, James K., and Bax, Jeroen J.

Subjects
Computed Tomography Angiography, Humans, Heart, cardiovascular diseases, Coronary Angiography, Tomography, X-Ray Computed, Risk Assessment, Article
Abstract

OBJECTIVES: To assess the prognostic value of a new, comprehensive coronary computed tomography angiography (CTA) score compared with the stenosis severity component of the Coronary Artery Disease – Reporting and Data System (CAD-RAD S). BACKGROUND: Current risk assessment with coronary CTA is mainly focused on maximal stenosis severity. Integration of plaque extent, location and composition in a comprehensive model may improve risk stratification. METHODS: A total of 2,134 patients with suspected but without known CAD were included. The predictive value of the comprehensive CTA score (ranging from 0–42 and divided into three groups: 0–5, 6–20, and >20) was compared with the CAD-RADS combined into 3 groups (0 – 30%, 30 – 70% and ≥70% stenosis). Its predictive performance was internally and externally validated (using the 5-year follow-up dataset of the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry (CONFIRM) registry, n = 1,971). RESULTS: Patients mean age was 55±13 years, mean follow-up 3.6 ± 2.8 years and 130 events (myocardial infarction or death) occurred. The new, comprehensive CTA score demonstrated strong and independent predictive value using Cox proportional hazard analysis. A model including clinical variables + comprehensive CTA score showed better discrimination of events compared with a model consisting of clinical variables + CAD-RADS (0.768 vs 0.742, P=0.001). Also, the comprehensive CTA score correctly reclassified a significant proportion of patients compared with conventional approach (net reclassification improvement 12.4%, P

Published
2019

35. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., van der Wall, Ernst E., Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., and van der Wall, Ernst E.

Abstract

Aims Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). Conclusions The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA

Published
2017

36. Influence of smoking on the prognostic value of cardiovascular computed tomography coronary angiography

Author

van Werkhoven, Jacob M., Schuijf, Joanne D., Pazhenkottil, Aju P., Herzog, Bernard A., Ghadri, Jelena R., Jukema, J. Wouter, Boersma, Eric, Kroft, Lucia J., de Roos, Albert, Kaufmann, Philipp A., Bax, Jeroen J., van Werkhoven, Jacob M., Schuijf, Joanne D., Pazhenkottil, Aju P., Herzog, Bernard A., Ghadri, Jelena R., Jukema, J. Wouter, Boersma, Eric, Kroft, Lucia J., de Roos, Albert, Kaufmann, Philipp A., and Bax, Jeroen J.

Abstract

Aims Computed tomography coronary angiography (CTA) is an important non-invasive imaging modality increasingly used for the diagnosis and prognosis of coronary artery disease (CAD). The purpose of the current study was to determine the influence of smoking status on the prognostic value of CTA in patients with suspected or known CAD. Methods and results In 1207 patients (57% male, age 57 ± 12 years) referred for CTA, the presence of significant CAD (≥50% stenosis) was determined. During follow-up (FU) the following events were recorded: all cause mortality, and non-fatal infarction. The prognostic value of CTA in smokers and non-smokers was compared using an interaction term in the Cox proportional hazard regression analysis. Significant CAD was observed in 327 patients (27%), and 273 patients (23%) were smokers. During a median FU time of 2.2 years, an event occurred in 50 patients. After correction for baseline characteristics including smoking in a multivariate model, significant CAD remained an independent predictor of events. Furthermore, a significant interaction (P < 0.05) was observed between significant CAD and smoking. The annualized event rate in smokers with significant CAD was 8.78% compared with 0.99% in smokers without significant CAD (P < 0.001). In non-smokers with significant CAD the annualized event rate was 2.07% compared with 1.01% in non-smokers without significant CAD (P= 0.058). Conclusion The prognostic value of CTA was significantly influenced by smoking status. The event rates in patients with significant CAD were approximately four-fold higher in smokers compared with non-smokers. These findings suggest that smoking cessation needs to be aggressively pursued, especially in smokers with significant CAD

Published
2017

37. Incremental prognostic value of multi-slice computed tomography coronary angiography over coronary artery calcium scoring in patients with suspected coronary artery disease

Author

van Werkhoven, Jacob M., Schuijf, Joanne D., Gaemperli, Oliver, Jukema, J. Wouter, Kroft, Lucia J., Boersma, Eric, Pazhenkottil, Aju, Valenta, Ines, Pundziute, Gabija, de Roos, Albert, van der Wall, Ernst E., Kaufmann, Philipp A., Bax, Jeroen J., van Werkhoven, Jacob M., Schuijf, Joanne D., Gaemperli, Oliver, Jukema, J. Wouter, Kroft, Lucia J., Boersma, Eric, Pazhenkottil, Aju, Valenta, Ines, Pundziute, Gabija, de Roos, Albert, van der Wall, Ernst E., Kaufmann, Philipp A., and Bax, Jeroen J.

Abstract

Aims The purpose of this study was to assess the relationship between calcium scoring (CS) and multi-slice computed tomography coronary angiography (MSCTA) and to determine if MSCTA has an incremental prognostic value to CS. Methods and results In 432 patients (59% male, age 58 ± 11 years) referred for cardiac evaluation owing to suspected coronary artery disease (CAD), CS and 64-slice MSCTA were performed. The following events were combined in a composite endpoint: all-cause mortality, non-fatal infarction, and unstable angina requiring revascularization. CS was 0 in 147 (34%) patients, CS 1-99 was present in 122 (28%), CS 100-399 in 75 (17%), CS 400-999 in 56 (13%), and CS ≥ 1000 in 32 (7%). MSCTA was normal in 133 (31%) patients, MSCTA 30-50% stenosis was observed in 190 (44%), and MSCTA ≥50% stenosis in 109 (25%). During follow-up [median 670 days (25th-75th percentile: 418-895)], an event occurred in 21 patients (4.9%). After multivariate correction for CS, MSCTA ≥ 50% stenosis, the number of diseased segments, obstructive segments, and non-calcified plaques were independent predictors with an incremental prognostic value to CS. Conclusion MSCTA provides additional information to CS regarding stenosis severity and plaque composition. This additional information was shown to translate into incremental prognostic value over CS

Published
2017

38. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Veltman, Caroline E, de Graaf, Fleur R, Schuijf, Joanne D, van Werkhoven, Jacob M, Jukema, J Wouter, Kaufmann, Philipp A, Pazhenkottil, Aju P, Kroft, Lucia J, Boersma, Eric, Bax, Jeroen J, Schalij, Martin J, van der Wall, Ernst E, Veltman, Caroline E, de Graaf, Fleur R, Schuijf, Joanne D, van Werkhoven, Jacob M, Jukema, J Wouter, Kaufmann, Philipp A, Pazhenkottil, Aju P, Kroft, Lucia J, Boersma, Eric, Bax, Jeroen J, Schalij, Martin J, and van der Wall, Ernst E

Abstract

AIMS: Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). METHODS AND RESULTS: The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). CONCLUSIONS: The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA.

Published
2012

39. Non-invasive computed tomography coronary angiography as a gatekeeper for invasive coronary angiography

Author

de Graaf, Fleur R., primary, van Velzen, Joëlla E., additional, de Boer, Stephanie M., additional, van Werkhoven, Jacob M., additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Sieders, Allard, additional, de Grooth, Greetje J., additional, Jukema, J. Wouter, additional, Schuijf, Joanne D., additional, Bax, Jeroen J., additional, Schalij, Martin J., additional, and van der Wall, Ernst E., additional

Published
2012
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40. Age- and gender-specific differences in the prognostic value of CT coronary angiography

Author

Yiu, Kai Hang, primary, de Graaf, Fleur R, additional, Schuijf, Joanne D, additional, van Werkhoven, Jacob M, additional, Marsan, Nina Ajmone, additional, Veltman, Caroline E, additional, de Roos, Albert, additional, Pazhenkottil, Aju, additional, Kroft, Lucia J, additional, Boersma, Eric, additional, Herzog, Bernhard, additional, Leung, Melissa, additional, Maffei, Erica, additional, Leung, Dominic Y, additional, Kaufmann, Philipp A, additional, Cademartiri, Filippo, additional, Bax, Jeroen J, additional, and Jukema, J Wouter, additional

Published
2011
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42. INVASIVE CORONARY ANGIOGRAPHIC AND REVASCULARIZATION RATES AFTER NON-INVASIVE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY

Author

Rianne de Graaf, Fleur, primary, Schuijf, Joanne D., additional, de Boer, Stephanie M., additional, van Werkhoven, Jacob M., additional, van Velzen, Joëlla E., additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Jukema, J. Wouter, additional, Schalij, Martin J., additional, van der Wall, Ernst E., additional, and Bax, Jeroen J., additional

Published
2011
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43. INCREMENTAL PROGNOSTIC VALUE OF RENAL DYSFUNCTION FOR THE PREDICTION OF CLINICAL OUTCOME IN PATIENTS UNDERGOING COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY

Author

Hang Yiu, Kai, primary, Schuijf, Joanne D., additional, van Werkhoven, Jacob M., additional, de Graaf, Fleur R., additional, van Velzen, Joella D., additional, Boogers, Mark J., additional, Roos, C.J., additional, Pazhenkottil, Aju, additional, Jukema, J Wouter, additional, Kroft, Lucia J., additional, Boersma, Eric, additional, Herzog, Bernhard, additional, de Roos, Albert, additional, Kaufmann, Philipp A., additional, and Bax, Jeroen J., additional

Published
2011
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44. Predictive Value of Multislice Computed Tomography Variables of Atherosclerosis for Ischemia on Stress-Rest Single-Photon Emission Computed Tomography

Author

van Velzen, Joëlla E., primary, Schuijf, Joanne D., additional, van Werkhoven, Jacob M., additional, Herzog, Bernhard A., additional, Pazhenkottil, Aju P., additional, Boersma, Eric, additional, de Graaf, Fleur R., additional, Scholte, Arthur J., additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Stokkel, Marcel P., additional, Jukema, J. Wouter, additional, Kaufmann, Philipp A., additional, van der Wall, Ernst E., additional, and Bax, Jeroen J., additional

Published
2010
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45. Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation

Author

Nucifora, Gaetano, primary, Schuijf, Joanne D., additional, van Werkhoven, Jacob M., additional, Trines, Serge A., additional, Kajander, Sami, additional, Tops, Laurens F., additional, Turta, Olli, additional, Jukema, J. Wouter, additional, Schreur, Joop H. M., additional, Heijenbrok, Mark W., additional, Gaemperli, Oliver, additional, Kaufmann, Philipp A., additional, Knuuti, Juhani, additional, van der Wall, Ernst E., additional, Schalij, Martin J., additional, and Bax, Jeroen J., additional

Published
2010
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46. Diabetes: Prognostic Value of CT Coronary Angiography—Comparison with a Nondiabetic Population

Author

Van Werkhoven, Jacob M., primary, Cademartiri, Filippo, additional, Seitun, Sara, additional, Maffei, Erica, additional, Palumbo, Alessandro, additional, Martini, Chiara, additional, Tarantini, Giuseppe, additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Weustink, Annick C., additional, Jukema, J. Wouter, additional, Ardissino, Diego, additional, Mollet, Nico R., additional, Schuijf, Joanne D., additional, and Bax, Jeroen J., additional

Published
2010
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47. Reduced Left Ventricular Torsion Early After Myocardial Infarction Is Related to Left Ventricular Remodeling

Author

Nucifora, Gaetano, primary, Marsan, Nina Ajmone, additional, Bertini, Matteo, additional, Delgado, Victoria, additional, Siebelink, Hans-Marc J., additional, van Werkhoven, Jacob M., additional, Scholte, Arthur J., additional, Schalij, Martin J., additional, van der Wall, Ernst E., additional, Holman, Eduard R., additional, and Bax, Jeroen J., additional

Published
2010
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49. Reply

Author

Van Werkhoven, Jacob M., primary, Schuijf, Joanne D., additional, and Bax, Jeroen J., additional

Published
2010
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50. ACCURACY OF NON-INVASIVE MULTISLICE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY; DETECTION OF SIGNIFICANT STENOSIS VERSUS DETECTION OF ATHEROSCLEROSIS

Author

Velzen, Joella E., primary, Schuijf, Joanne D., additional, de Graaf, Fleur R., additional, Pundziute, Gabija, additional, Spano, Fabrizio, additional, van Werkhoven, Jacob M., additional, Schalij, Martin J., additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Reiber, Johannes H., additional, Jukema, J. Wouter, additional, van der Wall, Ernst E., additional, and Bax, Jeroen J., additional

Published
2010
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