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1. Oncologic outcomes of de-escalating axillary treatment in clinically node-positive breast cancer patients treated with neoadjuvant systemic therapy – A two center cohort study

Author

Schipper, Robert-Jan, de Bruijn, Anne, van der Sangen, Maurice J.C., Bloemen, Johanne G., van den Hoven, Ingrid, Schepers, Ester E.M., Vriens, Birgit E.P., Boerman, Thom, Rijkaart, Dorien C., van de Winkel, Linda M.H., Brouwer, Christel, van Warmerdam, Laurence J.C., Gielens, Maaike P.M., van Bommel, Rob M.G., van Riet, Yvonne E., Voogd, Adri C., and Nieuwenhuijzen, Grard A.P.

Published
2024
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3. Oncologic outcomes of de-escalating axillary treatment in clinically node-positive breast cancer patients treated with neoadjuvant systemic therapy – A two center cohort study

Author

Schipper, Robert Jan, de Bruijn, Anne, van der Sangen, Maurice J.C., Bloemen, Johanne G., van den Hoven, Ingrid, Schepers, Ester E.M., Vriens, Birgit E.P., Boerman, Thom, Rijkaart, Dorien C., van de Winkel, Linda M.H., Brouwer, Christel, van Warmerdam, Laurence J.C., Gielens, Maaike P.M., van Bommel, Rob M.G., van Riet, Yvonne E., Voogd, Adri C., Nieuwenhuijzen, Grard A.P., Schipper, Robert Jan, de Bruijn, Anne, van der Sangen, Maurice J.C., Bloemen, Johanne G., van den Hoven, Ingrid, Schepers, Ester E.M., Vriens, Birgit E.P., Boerman, Thom, Rijkaart, Dorien C., van de Winkel, Linda M.H., Brouwer, Christel, van Warmerdam, Laurence J.C., Gielens, Maaike P.M., van Bommel, Rob M.G., van Riet, Yvonne E., Voogd, Adri C., and Nieuwenhuijzen, Grard A.P.

Abstract

Background: The aim of the present study was to report the 5-year axillary recurrence-free interval (aRFI) in clinically node-positive breast cancer patients treated according to a de-escalating axillary treatment protocol after neoadjuvant systemic therapy (NST). Methods: All patients diagnosed in two hospitals between October 2014 and March 2021 were identified retrospectively. Data on diagnostic workup, treatment and follow-up was collected. Adjuvant axillary treatment was considered based on the initial staging using 18F-FDG PET/CT and the results of axillary lymph node marking with a radioactive-iodine seed protocol or a targeted axillary dissection procedure. Follow-up was updated until 27th April 2024. Kaplan-Meier curves were calculated to report the 5-year aRFI with corresponding 95 % confident intervals (95%-CI). Results: A total of 199 patients were included. Axillary pathological complete response was reported in 66 (33.2 %). Based on the treatment protocol and initial clinical staging, no adjuvant axillary treatment was indicated in 30 patients (15 %), while 139 (70 %) received axillary radiotherapy without performance of an axillary lymph node dissection (ALND). The remaining 30 patients (15 %) underwent an ALND with additional locoregional radiotherapy. A median follow-up of 62 months (30–106) showed that 4 (2 %) patients experienced an axillary recurrence after 7, 8, 36 and 36 months, respectively. In all 4 patients, synchronous distant metastases were diagnosed. The estimated 5-year aRFI was 97.8 % (95%-CI 95.6–99.9 %) Conclusion: Although longer follow-up should be awaited before final conclusions can be drawn regarding the oncological safety of this approach, the implementation of a de-escalating axillary treatment protocol appears to be safe since the estimated 5-year aRFI is 97.8 %.

Published
2024

4. Neoadjuvant chemotherapy with or without anthracyclines in the presence of dual HER2 blockade for HER2-positive breast cancer (TRAIN-2): a multicentre, open-label, randomised, phase 3 trial

Author

van Ramshorst, Mette S, van der Voort, Anna, van Werkhoven, Erik D, Mandjes, Ingrid A, Kemper, Inge, Dezentjé, Vincent O, Oving, Irma M, Honkoop, Aafke H, Tick, Lidwine W, van de Wouw, Agnes J, Mandigers, Caroline M, van Warmerdam, Laurence J, Wesseling, Jelle, Vrancken Peeters, Marie-Jeanne T, Linn, Sabine C, and Sonke, Gabe S

Published
2018
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5. Safety and tolerability of subcutaneous trastuzumab for the adjuvant treatment of human epidermal growth factor receptor 2-positive early breast cancer: SafeHer phase III study's primary analysis of 2573 patients

Author

Koroveshi, Dhurata, Bouzid, Kamel, Casalnuovo, Monica, Cascallar, Diana, Korbenfeld, Ernesto Pablo, Bastick, Patricia, Beith, Jane, Colosimo, Maree, Friedlander, Michael, Ganju, Vinod, Green, Michael, Patterson, Kevin, Redfern, Andrew, Richardson, Gary, Ceric, Timur, Gordana, Kecman, Beato, Carlos Augusto, Ferrari, Marcela, Hegg, Roberto, Helena, Vanessa, Ismael, Gustavo Fernando, Lessa, Alvaro Edson, Mano, Max, Morelle, Alessandra, Nogueira, Jose Alberto, Timcheva, Konstanta, Tomova, Antoaneta, Tsakova, Maya, Zlatareva-Petrova, Ani, Asselah, Jamil, Assi, Hazem, Brezden-Masley, Christine, Chia, Stephen, Freedman, Ori, Harb, Mohammed, Joy, Anil Abraham, Kulkarni, Swati, Prady, Catherine, Gaete, Alejandro Andres Acevedo, Matamala, Luis, Torres, Roberto, Yanez, Eduardo, Franco, Sandra, Urrego, Marcela, Gugić, Damir, Vrbanec, Damir, Melichar, Bohuslav, Prausová, Jana, Vyzula, Rostislav, Pilarte, Rafael Gutierrez, León, María Isabel, Muñoz, Rene, Ramos, Glenda, Azeem, Hamdy Abdel, Aziz, Amr Abdel, El Zawahry, Heba, Osegueda, Finlander Rosales, Alexandre, Jerome, Artignan, Xavier, Barletta, Hugues, Beguier, Emmanuel, Berdah, Jean-François, Marty, Chantal Bernard, Bollet, Marc, Bourgeois, Hugues, Bressac, Claude, Burki, Franck, Campone, Mario, Coeffic, David, Cojocarasu, Oana Zveltlana, Dagada, Corinne, Dalenc, Florence, Del Piano, Francesco, Desauw, Christophe, Desmoulins, Isabelle, Dohollou, Nadine, Egreteau, Joelle, Ferrero, Jean-Marc, Foa, Cyril, Garidi, Reda, Gasnault, Laurent, Gligorov, Joseph, Guardiola, Emmanuel, Hamizi, Salima, Jarcau, Rosana, Jacquin, Jean-Philippe, Jaubert, Dominique, Jolimoy, Geneviève, Mineur, Hortense Laharie, Largillier, Remy, Leduc, Bernard, Martin, Philippe, Melis, Adrien, Monge, Jeremy, Moullet, Isabelle, Mousseau, Mireille, Nguyen, Suzanne, Orfeuvre, Hubert, Petit, Thierry, Pivot, Xavier, Priou, Frank, Bach, Isabelle Sillet, Simon, Helene, Stefani, Laetitia, Uwer, Lionel, Youssef, Ali, Aktas, Bahriye, von der Assen, Albert, Augustin, Doris, Balser, Christina, Bauer, Lelia-Eveline, Bechtner, Christina, Beyer, Greta, Brucker, Cosima, Bückner, Ute, Busch, Steffi, Christensen, Bernd, Deryal, Mustafa, Farrokh, Andre, Faust, Elke, Friedrichs, Kay, Graf, Heiko, Griesshammer, Martin, Grischke, Eva-Maria, Hänle, Claudia, Heider, Andrea, Henschen, Stephan, Hesse, Tobias, Jackisch, Christian, Kisro, Jens, Köhler, Andreas, Kuemmel, Sherko, Lampe, Dieter, Lantzsch, Tilmann, Latos, Kunibert, Lex, Benno, Liedtke, Cornelia, Luedders, Doerte, Maintz, Christoph, Müller, Volkmar, Overkamp, Friedrich, Park-Simon, Tjoung-won, Paul, Marion, Prechtl, Anita, Ringsdorf, Uta, Runnebaum, Ingo, Ruth, Sylvia, Salat, Christoph, Scheffen, Iris, Schilling, Jörg, Schmatloch, Sabine, Schmidt, Marcus, Schneeweiss, Andreas, Schrader, Iris, Seipelt, Gernot, Simon, Elke, Stefek, Andrea, Stickeler, Elmar, Thill, Marc, Tio, Joke, Tuczek, Anna, Warm, Mathias, Weigel, Michael, Wischnik, Arthur, Wojcinski, Sebastian, Ziegler-Löhr, Katja, Aravantinos, Gerasimos, Ardavanis, Alexandros, Fountzilas, George, Gogas, Helen, Kakolyris, Stylianos, Mavroudis, Dimitris, Papadimitriou, Christos, Papandreou, Christos, Papazisis, Konstantinos, Castro, Hugo, Hernandez-Monroy, Cesar Estuardo, Ngan, Roger, Yeo, Winnie, Bittner, Nora, Boer, Katalin, Csejtei, Andras, Horvath, Zsolt, Kocsis, Judit, Mangel, László Csaba, Mezei, Klara, Nagy, Zsuzsanna, Szanto, Janos, Atmakusuma, Djumhana, Fadjari, Heri, Kurnianda, Djohan, Prayogo, Nugroho, Tanggo, Eddie Herman, Coate, Linda, Hennessy, Bryan, Kelly, Cathy, Martin, Michael, Nasim, Saira, O'Connor, Miriam, Aieta, Michele, Allegrini, Giacomo, Amadori, Dino, Bidoli, Paolo, Biti, Giampaolo, Bordonaro, Roberto, Bottini, Alberto, Carterni, Giacomo, Cavanna, Luigi, Cazzaniga, Marina, Cognetti, Francesco, Contu, Antonio, Cruciani, Giorgio, Donadio, Michela, Falcone, Alfredo, Farci, Daniele, Forcignanò, R. Chiara, Frassoldati, Antonio, Gaion, Fernando, Gamucci, Teresa, Giotta, Francesco, de Laurentiis, Michele, Livi, Lorenzo, Lorusso, Vito, Maiello, Evaristo, Marchetti, Paolo, Mariani, Gabriella, Mion, Marta, Moscetti, Luca, Musolino, Antonino, Pazzola, Antonio, Pedrazzoli, Paolo, Pigi, Andrea, de Placido, Sabino, Caremoli, Elena Rota, Santoro, Armando, Tienghi, Amelia, Ahn, Jin-Seok, Jung, Kyung Hae, Lee, Keun Seok, Lee, Soo Hyeon, Seo, Jae Hong, Sohn, Joo-Hyuk, Cesas, Alvydas, Juozaityte, Elona, Cheah, Nellie Lay Chin, Chong, Flora Li Tze, Devi, Beena C.R., Phua, Vincent, Teoh, Darren, Ching, Lee Wei, Yusof, Mastura, Corona, Jorge, Dominguez, Adriana, Mendoza, René Lazaro González, Hernandez, Carlos Alberto, Ramiro, Alejandro Juarez, Santos, Juan Matos, Espinosa, Paola Morales, Villarreal Garza, Cynthia Mayte, Errihani, Hassan, Bakker, Sandra, van den Berkmortel, Franchette, Blaisse, R.J.B., Huinink, Daan ten Bokkel, van den Bosch, J., Braun, J.J., Dercksen, M.W., Droogendijk, Helga, Erdkamp, Frans, Haringhuizen, Annebeth, de Jongh, F.E., Kok, T.C., Los, Maartje, Madretsma, Stanley, Terwogt, Jetske M. Meerum, van der Padt, Annemieke, van Rossum-Schornagel, Quirine Clementine, Smilde, T.J., de Valk, Bart, van der Velden, Annette, van Warmerdam, Laurence, van de Wouw, A.J., North, Richard, Kersten, Christian, Mjaaland, Ingvild, Wist, Erik, Aziz, Zeba, Masood, Nehal, Rashid, Kamran, Shah, Mazhar, Alcedo, Juan Carlos, Aleman, Diana, Neciosup, Silvia, Reategui, Rocio, Valdiviezo, Natalia, Vera, Luis, Fernando, Gracieux, Roque, Fernando, Strebel, Heinrik Martin, Krzemieniecki, Krzysztof, Litwiniuk, Maria, Mruk, Andrzej, Pienkowski, Tadeusz, Sawrycki, Piotr, Slomian, Grzegorz, Tomczak, Piotr, Afonso, Noemia, Cardoso, Fátima, Damasceno, Margarida, Nave, Monica, Badulescu, Florinel, Ciule, Larisa, Curescu, Stefan, Eniu, Alexandru, Filip, Dumitru, Grecea, Daniela, Jinga, Dan-Corneliu, Lungulescu, Dan, Oprean, Cristina Marinela, Stanculeanu, Dana Lucia, Turdean, Maria, Dvornichenko, Viktoria, Emelyanov, Sergey, Lichinitser, Mikhail, Manikhas, Alexey, Sakaeva, Dina, Shirinkin, Vadim, Stroyakovskiy, Daniil, Abulkhair, Omalkhair, Zekri, Jamal, Filipovic, Sladjana, Kovcin, Vladimir, Nedovic, Jasmina, Pesic, Jasna, Vasovic, Suzana, Ng, Raymond, Bystricky, Branislav, Leskova, Jaroslava, Mardiak, Jozef, Mišurová, Etela, Wagnerova, Maria, Takač, Iztok, Demetriou, Georgia Savva, Dreosti, Lydia, Govender, Poovandren, Jordaan, Johannes Petrus, Veersamy, Petrosian, Romero, Jose Luis Alonso, Lopez, Norberto Batista, Arias, Carmen Cañabate, Chacon, Jose, Aramburo, Antonio Fernandez, Morales, Luis Antonio Fernandez, Garcia, Mirta, Estevez, Laura Garcia, Garcia-Palomo Perez, Andres, Garcia Saenz, Jose Angel, Garcia Sanchis, Laura, Cubells, Laia Garrigos, Cortijo, Lucia Gonzalez, Santiago, Santiago Gonzalez, De Aranguiz, Blanca Hernando Fernandez, Mañas, José Juan Illarramendi, Gallego, Pedro Jimenez, Cussac, Antonio Llombart, Ferrandiz, Cristina Llorca, Garrido, Maria Lomas, Alvarez, Pilar Lopez, Vega, Jose Manuel Lopez, Del Prado, Purificacion Martinez, Jañez, Noelia Martinez, Murillo, Serafin Morales, Rosales, Adolfo Murias, Jaso, Laura Murillo, Fernandez, Ignacio Pelaez, Martorell, Antonia Perello, Carrion, Ramon Perez, Simon, Sonia Pernas, Alcibar, Arrate Plazaola, Lorenzo, Jose Ponce, Garcia, Vanesa Quiroga, Asensio, Teresa Ramon y Cajal, Maicas, Maria Dolores Torregrosa, Villanueva Silva, Maria Jose, Killander, Fredrika, Svensson, Jan Henry, Fehr, Mathias, Hauser, Nik, Müller, Andreas, Pagani, Olivia, Passmann-Kegel, Heike, Popescu, Razvan, Rabaglio, Manuela, Rauch, Daniel, Schlatter, Christina, Zaman, Khalil, Chang, Tsai-Wang, Huang, Chiun-Sheng, Wang, Hwei-Chung, Yu, Jyh-Cherng, Bandidwattanawong, Chanyoot, Maneechavakajorn, Jedzada, Seetalarom, Kasan, Dejthevaporn, Thitiya (Sirisinha), Somwangprasert, Areewan, Vongsaisuwon, Mawin, Akbulut, Hakan, Altundag, Kadri, Arican, Ali, Bozcuk, Hakan, Eralp, Yesim, Idris, Mohamed, Isikdogan, Abdurrahman, Senol, Coskun Hasan, Sevinc, Alper, Uygun, Kazim, Yucel, Eftal, Yucel, Idris, Yumuk, Fulden, Shparyk, Yaroslav, Voitko, Nataliia, Jaloudi, Mohammed, Adams, Jocelyn, Agrawal, Rajiv, Ahmed, Samreen, Alhasso, Abdulla, Allerton, Rozenn, Anwar, Suhail, Archer, Caroline, Ashford, Richard, Barraclough, Lisa, Bertelli, Gianfilippo, Bishop, Jill, Branson, Tony, Butt, Mohammed, Chakrabarti, Amit, Chakraborti, Prabir, Churn, Mark, Crowley, Clare, Davis, Ruth, Dhadda, Amandeep, Eldeeb, Hany, Fraser, Judith, Hall, Julia, Hickish, Tamas, Hogg, Martin, Howe, Theresa, Joffe, Jonathan, Kelleher, Muireann, Kelly, Stephen, Kendall, Anne, Kristeleit, Hartmut, Lumsden, Graeme, Macmillan, Craig, MacPherson, Iain, Malik, Zafar, Mithal, Natasha, Neal, Anthony, Panwar, Udaiveer, Proctor, Andrew, Proctor, Steven John, Raj, Sanjay, Rehman, Shazza, Sandri, Ines, Scatchard, Kate, Sherwin, Elizabeth, Sims, Eliot, Singer, Julian, Smith, Sarah, Tahir, Saad, Taylor, Wendy, Tsalic, Medy, Verrill, Mark, Wardley, Andrew, Waters, Simon, Wheatley, Duncan, Wright, Kathryn, Yuille, Frances, Alonso, Isabel, Artagaveytia, Nora, Rodriguez, Robinson, Arbona, Esther, Garcia, Yuraima, Lion, Lorena, Marcano, Dalila, Van Thuan, Tran, Gligorov, J., Ataseven, B., Verrill, M., De Laurentiis, M., Jung, K.H., Azim, H.A., Al-Sakaff, N., Lauer, S., Shing, M., and Pivot, X.

Published
2017
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6. Intermittent versus continuous first-line treatment for HER2-negative metastatic breast cancer: the Stop & Go study of the Dutch Breast Cancer Research Group (BOOG)

Author

Claessens, Anouk K. M., Bos, Monique E. M. M., Lopez-Yurda, Marta, Bouma, Jeanette M., Rademaker-Lakhai, Jeany M., Honkoop, Aafke H., de Graaf, Hiltje, van Druten, Edith, van Warmerdam, Laurence J. C., van der Sangen, Maurice J. C., Tjan-Heijnen, Vivianne C. G., Erdkamp, Frans L. G., and The Dutch Breast Cancer Research Group (BOOG)

Published
2018
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8. Addition of zoledronic acid to neoadjuvant chemotherapy is not beneficial in patients with HER2-negative stage II/III breast cancer: 5-year survival analysis of the NEOZOTAC trial (BOOG 2010-01)

Author

de Groot, Stefanie, Pijl, Hanno, Charehbili, Ayoub, van de Ven, Saskia, Smit, Vincent T. H. B. M., Meershoek-Klein Kranenbarg, Elma, Heijns, Joan B., van Warmerdam, Laurence J. C., Kessels, Lonneke W., Dercksen, M. Wouter, Pepels, Manon J. A. E., van Laarhoven, Hanneke W. M., Vriens, Birgit E. P. J., Putter, Hein, Fiocco, Marta, Liefers, Gerrit-Jan, van der Hoeven, Jacobus J. M., Nortier, Johan W. R., Kroep, Judith R., and on behalf of the Dutch Breast Cancer Research Group

Published
2019
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11. Three-Year Follow-up of Neoadjuvant Chemotherapy With or Without Anthracyclines in the Presence of DualERBB2Blockade in Patients WithERBB2-Positive Breast Cancer

Author

van der Voort, Anna, primary, van Ramshorst, Mette S., additional, van Werkhoven, Erik D., additional, Mandjes, Ingrid A., additional, Kemper, Inge, additional, Vulink, Annelie J., additional, Oving, Irma M., additional, Honkoop, Aafke H., additional, Tick, Lidwine W., additional, van de Wouw, Agnes J., additional, Mandigers, Caroline M., additional, van Warmerdam, Laurence J., additional, Wesseling, Jelle, additional, Vrancken Peeters, Marie-Jeanne T., additional, Linn, Sabine C., additional, and Sonke, Gabe S., additional

Published
2021
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20. Three-Year Follow-up of Neoadjuvant Chemotherapy With or Without Anthracyclines in the Presence of Dual ERBB2 Blockade in Patients With ERBB2-Positive Breast Cancer: A Secondary Analysis of the TRAIN-2 Randomized, Phase 3 Trial.

Author

van der Voort, Anna, van Ramshorst, Mette S., van Werkhoven, Erik D., Mandjes, Ingrid A., Kemper, Inge, Vulink, Annelie J., Oving, Irma M., Honkoop, Aafke H., Tick, Lidwine W., van de Wouw, Agnes J., Mandigers, Caroline M., van Warmerdam, Laurence J., Wesseling, Jelle, Vrancken Peeters, Marie-Jeanne T., Linn, Sabine C., and Sonke, Gabe S.

Published
2021
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22. Predicting breast and axillary response after neoadjuvant treatment for breast cancer: The role of histology vs receptor status

Author

Vugts, Guusje, Van den Heuvel, Faizah, Maaskant-Braat, Adriana J. G., Voogd, Adri C., Van Warmerdam, Laurence J. C., Nieuwenhuijzen, Grard A. P., Van der Sangen, Maurice J. C., Vugts, Guusje, Van den Heuvel, Faizah, Maaskant-Braat, Adriana J. G., Voogd, Adri C., Van Warmerdam, Laurence J. C., Nieuwenhuijzen, Grard A. P., and Van der Sangen, Maurice J. C.

Abstract

Purpose Neoadjuvant systemic treatment (NST) is increasingly administered in breast cancer patients. This study was conducted to identify predictors for tumor response in the breast and axilla. Methods All female patients with nonmetastatic, noninflammatory breast cancer receiving NST between 2003-2013 at the Catharina Cancer Institute in Eindhoven, The Netherlands, were included. Results The majority of 216 of the 337 patients receiving NST (65%) presented with a cT2 tumor. In 159 patients (47%), the axilla was clinically node positive. A pathologic complete response (pCR) in the breast was achieved in 83 patients (24.6%), and a pCR in the axilla in 65 node-positive patients (40.9%). The triple-negative (OR 4.29, 95% CI 2.15-8.55) and hormone receptor (HR)-negative/HER2-positive tumors (OR 3.73, 95% CI 1.59-8.75) were associated with in-breast pCR. Patients with invasive lobular carcinoma (ILC) were less likely to experience in-breast pCR (OR 0.10, 95% CI 0.01-0.73) than those with invasive ductal cancer. Axillary pCR was found in 65 clinically node-positive patients (41%). Axillary pCR was more likely to occur in HR-positive/HER2-positive (OR 6.24, 95% CI 1.86-20.90) and HR-negative/HER2-positive tumors (OR 6.41, 95% CI 1.95-21.06), compared to HER2-negative disease. In-breast pCR was strongly associated with axillary pCR (OR 10.89, 95% CI 4.20-28.22). Conclusion Response to NST in the breast and axilla is largely determined by receptor status, with high pCR rates occurring in HER2-positive and triple-negative tumors. For axillary pCR, in-breast pCR and HER2-positive disease are the most important predictive factors.

Published
2018

23. Safety and tolerability of subcutaneous trastuzumab for the adjuvant treatment of human epidermal growth factor receptor 2-positive early breast cancer: SafeHer phase III study's primary analysis of 2573 patients

Author

Gligorov, J., primary, Ataseven, B., additional, Verrill, M., additional, De Laurentiis, M., additional, Jung, K.H., additional, Azim, H.A., additional, Al-Sakaff, N., additional, Lauer, S., additional, Shing, M., additional, Pivot, X., additional, Koroveshi, Dhurata, additional, Bouzid, Kamel, additional, Casalnuovo, Monica, additional, Cascallar, Diana, additional, Korbenfeld, Ernesto Pablo, additional, Bastick, Patricia, additional, Beith, Jane, additional, Colosimo, Maree, additional, Friedlander, Michael, additional, Ganju, Vinod, additional, Green, Michael, additional, Patterson, Kevin, additional, Redfern, Andrew, additional, Richardson, Gary, additional, Ceric, Timur, additional, Gordana, Kecman, additional, Beato, Carlos Augusto, additional, Ferrari, Marcela, additional, Hegg, Roberto, additional, Helena, Vanessa, additional, Ismael, Gustavo Fernando, additional, Lessa, Alvaro Edson, additional, Mano, Max, additional, Morelle, Alessandra, additional, Nogueira, Jose Alberto, additional, Timcheva, Konstanta, additional, Tomova, Antoaneta, additional, Tsakova, Maya, additional, Zlatareva-Petrova, Ani, additional, Asselah, Jamil, additional, Assi, Hazem, additional, Brezden-Masley, Christine, additional, Chia, Stephen, additional, Freedman, Ori, additional, Harb, Mohammed, additional, Joy, Anil Abraham, additional, Kulkarni, Swati, additional, Prady, Catherine, additional, Gaete, Alejandro Andres Acevedo, additional, Matamala, Luis, additional, Torres, Roberto, additional, Yanez, Eduardo, additional, Franco, Sandra, additional, Urrego, Marcela, additional, Gugić, Damir, additional, Vrbanec, Damir, additional, Melichar, Bohuslav, additional, Prausová, Jana, additional, Vyzula, Rostislav, additional, Pilarte, Rafael Gutierrez, additional, León, María Isabel, additional, Muñoz, Rene, additional, Ramos, Glenda, additional, Azeem, Hamdy Abdel, additional, Aziz, Amr Abdel, additional, El Zawahry, Heba, additional, Osegueda, Finlander Rosales, additional, Alexandre, Jerome, additional, Artignan, Xavier, additional, Barletta, Hugues, additional, Beguier, Emmanuel, additional, Berdah, Jean-François, additional, Marty, Chantal Bernard, additional, Bollet, Marc, additional, Bourgeois, Hugues, additional, Bressac, Claude, additional, Burki, Franck, additional, Campone, Mario, additional, Coeffic, David, additional, Cojocarasu, Oana Zveltlana, additional, Dagada, Corinne, additional, Dalenc, Florence, additional, Del Piano, Francesco, additional, Desauw, Christophe, additional, Desmoulins, Isabelle, additional, Dohollou, Nadine, additional, Egreteau, Joelle, additional, Ferrero, Jean-Marc, additional, Foa, Cyril, additional, Garidi, Reda, additional, Gasnault, Laurent, additional, Gligorov, Joseph, additional, Guardiola, Emmanuel, additional, Hamizi, Salima, additional, Jarcau, Rosana, additional, Jacquin, Jean-Philippe, additional, Jaubert, Dominique, additional, Jolimoy, Geneviève, additional, Mineur, Hortense Laharie, additional, Largillier, Remy, additional, Leduc, Bernard, additional, Martin, Philippe, additional, Melis, Adrien, additional, Monge, Jeremy, additional, Moullet, Isabelle, additional, Mousseau, Mireille, additional, Nguyen, Suzanne, additional, Orfeuvre, Hubert, additional, Petit, Thierry, additional, Pivot, Xavier, additional, Priou, Frank, additional, Bach, Isabelle Sillet, additional, Simon, Helene, additional, Stefani, Laetitia, additional, Uwer, Lionel, additional, Youssef, Ali, additional, Aktas, Bahriye, additional, von der Assen, Albert, additional, Augustin, Doris, additional, Balser, Christina, additional, Bauer, Lelia-Eveline, additional, Bechtner, Christina, additional, Beyer, Greta, additional, Brucker, Cosima, additional, Bückner, Ute, additional, Busch, Steffi, additional, Christensen, Bernd, additional, Deryal, Mustafa, additional, Farrokh, Andre, additional, Faust, Elke, additional, Friedrichs, Kay, additional, Graf, Heiko, additional, Griesshammer, Martin, additional, Grischke, Eva-Maria, additional, Hänle, Claudia, additional, Heider, Andrea, additional, Henschen, Stephan, additional, Hesse, Tobias, additional, Jackisch, Christian, additional, Kisro, Jens, additional, Köhler, Andreas, additional, Kuemmel, Sherko, additional, Lampe, Dieter, additional, Lantzsch, Tilmann, additional, Latos, Kunibert, additional, Lex, Benno, additional, Liedtke, Cornelia, additional, Luedders, Doerte, additional, Maintz, Christoph, additional, Müller, Volkmar, additional, Overkamp, Friedrich, additional, Park-Simon, Tjoung-won, additional, Paul, Marion, additional, Prechtl, Anita, additional, Ringsdorf, Uta, additional, Runnebaum, Ingo, additional, Ruth, Sylvia, additional, Salat, Christoph, additional, Scheffen, Iris, additional, Schilling, Jörg, additional, Schmatloch, Sabine, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schrader, Iris, additional, Seipelt, Gernot, additional, Simon, Elke, additional, Stefek, Andrea, additional, Stickeler, Elmar, additional, Thill, Marc, additional, Tio, Joke, additional, Tuczek, Anna, additional, Warm, Mathias, additional, Weigel, Michael, additional, Wischnik, Arthur, additional, Wojcinski, Sebastian, additional, Ziegler-Löhr, Katja, additional, Aravantinos, Gerasimos, additional, Ardavanis, Alexandros, additional, Fountzilas, George, additional, Gogas, Helen, additional, Kakolyris, Stylianos, additional, Mavroudis, Dimitris, additional, Papadimitriou, Christos, additional, Papandreou, Christos, additional, Papazisis, Konstantinos, additional, Castro, Hugo, additional, Hernandez-Monroy, Cesar Estuardo, additional, Ngan, Roger, additional, Yeo, Winnie, additional, Bittner, Nora, additional, Boer, Katalin, additional, Csejtei, Andras, additional, Horvath, Zsolt, additional, Kocsis, Judit, additional, Mangel, László Csaba, additional, Mezei, Klara, additional, Nagy, Zsuzsanna, additional, Szanto, Janos, additional, Atmakusuma, Djumhana, additional, Fadjari, Heri, additional, Kurnianda, Djohan, additional, Prayogo, Nugroho, additional, Tanggo, Eddie Herman, additional, Coate, Linda, additional, Hennessy, Bryan, additional, Kelly, Cathy, additional, Martin, Michael, additional, Nasim, Saira, additional, O'Connor, Miriam, additional, Aieta, Michele, additional, Allegrini, Giacomo, additional, Amadori, Dino, additional, Bidoli, Paolo, additional, Biti, Giampaolo, additional, Bordonaro, Roberto, additional, Bottini, Alberto, additional, Carterni, Giacomo, additional, Cavanna, Luigi, additional, Cazzaniga, Marina, additional, Cognetti, Francesco, additional, Contu, Antonio, additional, Cruciani, Giorgio, additional, Donadio, Michela, additional, Falcone, Alfredo, additional, Farci, Daniele, additional, Forcignanò, R. Chiara, additional, Frassoldati, Antonio, additional, Gaion, Fernando, additional, Gamucci, Teresa, additional, Giotta, Francesco, additional, de Laurentiis, Michele, additional, Livi, Lorenzo, additional, Lorusso, Vito, additional, Maiello, Evaristo, additional, Marchetti, Paolo, additional, Mariani, Gabriella, additional, Mion, Marta, additional, Moscetti, Luca, additional, Musolino, Antonino, additional, Pazzola, Antonio, additional, Pedrazzoli, Paolo, additional, Pigi, Andrea, additional, de Placido, Sabino, additional, Caremoli, Elena Rota, additional, Santoro, Armando, additional, Tienghi, Amelia, additional, Ahn, Jin-Seok, additional, Jung, Kyung Hae, additional, Lee, Keun Seok, additional, Lee, Soo Hyeon, additional, Seo, Jae Hong, additional, Sohn, Joo-Hyuk, additional, Cesas, Alvydas, additional, Juozaityte, Elona, additional, Cheah, Nellie Lay Chin, additional, Chong, Flora Li Tze, additional, Devi, Beena C.R., additional, Phua, Vincent, additional, Teoh, Darren, additional, Ching, Lee Wei, additional, Yusof, Mastura, additional, Corona, Jorge, additional, Dominguez, Adriana, additional, Mendoza, René Lazaro González, additional, Hernandez, Carlos Alberto, additional, Ramiro, Alejandro Juarez, additional, Santos, Juan Matos, additional, Espinosa, Paola Morales, additional, Villarreal Garza, Cynthia Mayte, additional, Errihani, Hassan, additional, Bakker, Sandra, additional, van den Berkmortel, Franchette, additional, Blaisse, R.J.B., additional, Huinink, Daan ten Bokkel, additional, van den Bosch, J., additional, Braun, J.J., additional, Dercksen, M.W., additional, Droogendijk, Helga, additional, Erdkamp, Frans, additional, Haringhuizen, Annebeth, additional, de Jongh, F.E., additional, Kok, T.C., additional, Los, Maartje, additional, Madretsma, Stanley, additional, Terwogt, Jetske M. Meerum, additional, van der Padt, Annemieke, additional, van Rossum-Schornagel, Quirine Clementine, additional, Smilde, T.J., additional, de Valk, Bart, additional, van der Velden, Annette, additional, van Warmerdam, Laurence, additional, van de Wouw, A.J., additional, North, Richard, additional, Kersten, Christian, additional, Mjaaland, Ingvild, additional, Wist, Erik, additional, Aziz, Zeba, additional, Masood, Nehal, additional, Rashid, Kamran, additional, Shah, Mazhar, additional, Alcedo, Juan Carlos, additional, Aleman, Diana, additional, Neciosup, Silvia, additional, Reategui, Rocio, additional, Valdiviezo, Natalia, additional, Vera, Luis, additional, Fernando, Gracieux, additional, Roque, Fernando, additional, Strebel, Heinrik Martin, additional, Krzemieniecki, Krzysztof, additional, Litwiniuk, Maria, additional, Mruk, Andrzej, additional, Pienkowski, Tadeusz, additional, Sawrycki, Piotr, additional, Slomian, Grzegorz, additional, Tomczak, Piotr, additional, Afonso, Noemia, additional, Cardoso, Fátima, additional, Damasceno, Margarida, additional, Nave, Monica, additional, Badulescu, Florinel, additional, Ciule, Larisa, additional, Curescu, Stefan, additional, Eniu, Alexandru, additional, Filip, Dumitru, additional, Grecea, Daniela, additional, Jinga, Dan-Corneliu, additional, Lungulescu, Dan, additional, Oprean, Cristina Marinela, additional, Stanculeanu, Dana Lucia, additional, Turdean, Maria, additional, Dvornichenko, Viktoria, additional, Emelyanov, Sergey, additional, Lichinitser, Mikhail, additional, Manikhas, Alexey, additional, Sakaeva, Dina, additional, Shirinkin, Vadim, additional, Stroyakovskiy, Daniil, additional, Abulkhair, Omalkhair, additional, Zekri, Jamal, additional, Filipovic, Sladjana, additional, Kovcin, Vladimir, additional, Nedovic, Jasmina, additional, Pesic, Jasna, additional, Vasovic, Suzana, additional, Ng, Raymond, additional, Bystricky, Branislav, additional, Leskova, Jaroslava, additional, Mardiak, Jozef, additional, Mišurová, Etela, additional, Wagnerova, Maria, additional, Takač, Iztok, additional, Demetriou, Georgia Savva, additional, Dreosti, Lydia, additional, Govender, Poovandren, additional, Jordaan, Johannes Petrus, additional, Veersamy, Petrosian, additional, Romero, Jose Luis Alonso, additional, Lopez, Norberto Batista, additional, Arias, Carmen Cañabate, additional, Chacon, Jose, additional, Aramburo, Antonio Fernandez, additional, Morales, Luis Antonio Fernandez, additional, Garcia, Mirta, additional, Estevez, Laura Garcia, additional, Garcia-Palomo Perez, Andres, additional, Garcia Saenz, Jose Angel, additional, Garcia Sanchis, Laura, additional, Cubells, Laia Garrigos, additional, Cortijo, Lucia Gonzalez, additional, Santiago, Santiago Gonzalez, additional, De Aranguiz, Blanca Hernando Fernandez, additional, Mañas, José Juan Illarramendi, additional, Gallego, Pedro Jimenez, additional, Cussac, Antonio Llombart, additional, Ferrandiz, Cristina Llorca, additional, Garrido, Maria Lomas, additional, Alvarez, Pilar Lopez, additional, Vega, Jose Manuel Lopez, additional, Del Prado, Purificacion Martinez, additional, Jañez, Noelia Martinez, additional, Murillo, Serafin Morales, additional, Rosales, Adolfo Murias, additional, Jaso, Laura Murillo, additional, Fernandez, Ignacio Pelaez, additional, Martorell, Antonia Perello, additional, Carrion, Ramon Perez, additional, Simon, Sonia Pernas, additional, Alcibar, Arrate Plazaola, additional, Lorenzo, Jose Ponce, additional, Garcia, Vanesa Quiroga, additional, Asensio, Teresa Ramon y Cajal, additional, Maicas, Maria Dolores Torregrosa, additional, Villanueva Silva, Maria Jose, additional, Killander, Fredrika, additional, Svensson, Jan Henry, additional, Fehr, Mathias, additional, Hauser, Nik, additional, Müller, Andreas, additional, Pagani, Olivia, additional, Passmann-Kegel, Heike, additional, Popescu, Razvan, additional, Rabaglio, Manuela, additional, Rauch, Daniel, additional, Schlatter, Christina, additional, Zaman, Khalil, additional, Chang, Tsai-Wang, additional, Huang, Chiun-Sheng, additional, Wang, Hwei-Chung, additional, Yu, Jyh-Cherng, additional, Bandidwattanawong, Chanyoot, additional, Maneechavakajorn, Jedzada, additional, Seetalarom, Kasan, additional, Dejthevaporn, Thitiya (Sirisinha), additional, Somwangprasert, Areewan, additional, Vongsaisuwon, Mawin, additional, Akbulut, Hakan, additional, Altundag, Kadri, additional, Arican, Ali, additional, Bozcuk, Hakan, additional, Eralp, Yesim, additional, Idris, Mohamed, additional, Isikdogan, Abdurrahman, additional, Senol, Coskun Hasan, additional, Sevinc, Alper, additional, Uygun, Kazim, additional, Yucel, Eftal, additional, Yucel, Idris, additional, Yumuk, Fulden, additional, Shparyk, Yaroslav, additional, Voitko, Nataliia, additional, Jaloudi, Mohammed, additional, Adams, Jocelyn, additional, Agrawal, Rajiv, additional, Ahmed, Samreen, additional, Alhasso, Abdulla, additional, Allerton, Rozenn, additional, Anwar, Suhail, additional, Archer, Caroline, additional, Ashford, Richard, additional, Barraclough, Lisa, additional, Bertelli, Gianfilippo, additional, Bishop, Jill, additional, Branson, Tony, additional, Butt, Mohammed, additional, Chakrabarti, Amit, additional, Chakraborti, Prabir, additional, Churn, Mark, additional, Crowley, Clare, additional, Davis, Ruth, additional, Dhadda, Amandeep, additional, Eldeeb, Hany, additional, Fraser, Judith, additional, Hall, Julia, additional, Hickish, Tamas, additional, Hogg, Martin, additional, Howe, Theresa, additional, Joffe, Jonathan, additional, Kelleher, Muireann, additional, Kelly, Stephen, additional, Kendall, Anne, additional, Kristeleit, Hartmut, additional, Lumsden, Graeme, additional, Macmillan, Craig, additional, MacPherson, Iain, additional, Malik, Zafar, additional, Mithal, Natasha, additional, Neal, Anthony, additional, Panwar, Udaiveer, additional, Proctor, Andrew, additional, Proctor, Steven John, additional, Raj, Sanjay, additional, Rehman, Shazza, additional, Sandri, Ines, additional, Scatchard, Kate, additional, Sherwin, Elizabeth, additional, Sims, Eliot, additional, Singer, Julian, additional, Smith, Sarah, additional, Tahir, Saad, additional, Taylor, Wendy, additional, Tsalic, Medy, additional, Verrill, Mark, additional, Wardley, Andrew, additional, Waters, Simon, additional, Wheatley, Duncan, additional, Wright, Kathryn, additional, Yuille, Frances, additional, Alonso, Isabel, additional, Artagaveytia, Nora, additional, Rodriguez, Robinson, additional, Arbona, Esther, additional, Garcia, Yuraima, additional, Lion, Lorena, additional, Marcano, Dalila, additional, and Van Thuan, Tran, additional

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2017
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24. Neutrophil Recovery in Breast Cancer Patients Receiving Docetaxel-Containing Chemotherapy with and without Granulocyte Colony-Stimulating Factor Prophylaxis

Author

Aarts, Maureen J., primary, Vriens, Birgit E., additional, de Boer, Maaike, additional, Peters, Frank P., additional, Mandigers, Caroline M., additional, Dercksen, M. Wouter, additional, Stouthard, Jacqueline M., additional, Tol, Jolien, additional, van Warmerdam, Laurence J., additional, van de Wouw, Agnes J., additional, Jacobs, Esther M., additional, van der Rijt, Carin C.D., additional, Smilde, Tineke J., additional, van der Velden, Annette W., additional, Peer, Nelly, additional, and Tjan-Heijnen, Vivianne C.G., additional

Published
2017
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26. Primary Granulocyte Colony-Stimulating Factor Prophylaxis During the First Two Cycles Only or Throughout All Chemotherapy Cycles in Patients With Breast Cancer at Risk for Febrile Neutropenia

Author

Aarts, Maureen J., primary, Peters, Frank P., additional, Mandigers, Caroline M., additional, Dercksen, M. Wouter, additional, Stouthard, Jacqueline M., additional, Nortier, Hans J., additional, van Laarhoven, Hanneke W., additional, van Warmerdam, Laurence J., additional, van de Wouw, Agnes J., additional, Jacobs, Esther M., additional, Mattijssen, Vera, additional, van der Rijt, Carin C., additional, Smilde, Tineke J., additional, van der Velden, Annette W., additional, Temizkan, Mehmet, additional, Batman, Erdogan, additional, Muller, Erik W., additional, van Gastel, Saskia M., additional, Borm, George F., additional, and Tjan-Heijnen, Vivianne C.G., additional

Published
2013
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27. Cost Effectiveness of Primary Pegfilgrastim Prophylaxis in Patients With Breast Cancer at Risk of Febrile Neutropenia

Author

Aarts, Maureen J., primary, Grutters, Janneke P., additional, Peters, Frank P., additional, Mandigers, Caroline M., additional, Dercksen, M. Wouter, additional, Stouthard, Jacqueline M., additional, Nortier, Hans J., additional, van Laarhoven, Hanneke W., additional, van Warmerdam, Laurence J., additional, van de Wouw, Agnes J., additional, Jacobs, Esther M., additional, Mattijssen, Vera, additional, van der Rijt, Carin C., additional, Smilde, Tineke J., additional, van der Velden, Annette W., additional, Temizkan, Mehmet, additional, Batman, Erdogan, additional, Muller, Erik W., additional, van Gastel, Saskia M., additional, Joore, Manuela A., additional, Borm, George F., additional, and Tjan-Heijnen, Vivianne C., additional

Published
2013
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34. Urinary excretion of paclitaxel and metabolites in a large series of study.

Author

Panday, Vinodh R. Nannan, Rosing, Hilde, Huizing, Manon T., Koopman, Francesca J., van Warmerdam, Laurence J.C., Huinik, Wim W. ten Bokkel, and Beijnen, Jos H.

Subjects
PACLITAXEL, URINALYSIS
Abstract

Examines the relationships between mean urinary paclitaxel excretion fraction and measured paclitaxel area under plasma concentration versus time curve. Side effects of paclitaxel; Determination of paclitaxel urinary fraction; Detection of paclitaxel metabolites in the urine.

Published
1998
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