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205 results on '"van Schooten, F. J."'

8. Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia

Author

Heijnen, NFL, Hagens, LA, van Schooten, F-J, Bos, LDJ, van der Horst, ICC, Mommers, A, Schultz, MJ, Smit, MR, Bergmans, DCJJ, Smolinska, A, and Schnabel, RM

Abstract

Rationale The concentration of octane and acetaldehyde in exhaled breath has good diagnostic accuracy for acute respiratory distress syndrome (ARDS). We aimed to determine whether breath octane and acetaldehyde are able to distinguish the presence and absence of ARDS in critically ill patients suspected to have ventilator-associated pneumonia (VAP). Methods This is a secondary analysis of a prospective observational study into exhaled breath analysis using gas chromatography–time-of-flight mass spectrometry. Difference in the relative abundance of octane and acetaldehyde in exhaled breath was compared between patients with and without ARDS using the Mann–Whitney U-test and the association was quantified using logistic regression. The discriminative accuracy of octane and acetaldehyde, alone or in combination, was calculated using the area under the receiver operating characteristic curve (AUROCC). Results We included 98 patients, of whom 32 had ARDS and 66 did not. The area under the acetaldehyde peak was higher in patients with ARDS (p=0.03), and associated with the presence of ARDS (OR 1.06 per 100 000 count change, 95% CI 1.02–1.13 per 100 000 count change; p=0.01). A combined model with octane and acetaldehyde showed a high specificity and low sensitivity (90% and 40.6%, respectively), with a low accuracy (AUROCC 0.65, 95% CI 0.53–0.78). Conclusion Patients suspected to have VAP with ARDS had a higher acetaldehyde concentration in exhaled breath than patients suspected to have VAP without ARDS. However, in this patient population, discrimination of these breath biomarkers for ARDS was poor, indicating the difficulty of translating diagnostic tests between clinical settings.

Published
2022
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26. A european respiratory society technical standard: Exhaled biomarkers in lung disease

Author

Horváth, I. Barnes, P.J. Loukides, S. Sterk, P.J. Högman, M. Olin, A.-C. Amann, A. Antus, B. Baraldi, E. Bikov, A. Boots, A.W. Bos, L.D. Brinkman, P. Bucca, C. Carpagnano, G.E. Corradi, M. Cristescu, S. De Jongste, J.C. Dinh-Xuan, A.-T. Dompeling, E. Fens, N. Fowler, S. Hohlfeld, J.M. Holz, O. Jöbsis, Q. De Kant, K.V. Knobel, H.H. Kostikas, K. Lehtimäki, L. Lundberg, J.O. Montuschi, P. Van Muylem, A. Pennazza, G. Reinhold, P. Ricciardolo, F.L.M. Rosias, P. Santonico, M. van der Schee, M.P. van Schooten, F.-J. Spanevello, A. Tonia, T. Vink, T.J.

Subjects
respiratory tract diseases
Abstract

Breath tests cover the fraction of nitric oxide in expired gas (FENO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FENO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FENO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management. Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members. Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised. Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice. Copyright ©ERS 2017

Published
2017

31. Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in mouth floor and buccal mucosa cells of smokers and nonsmokers

Author

Besaratinia, A., Besarati Nia, A., van Straaten, H. W., Godschalk, R. W., van Zandwijk, N., Balm, A. J., Kleinjans, J. C., van Schooten, F. J., Gezondheidsrisico Analyse en Toxicologie, Anatomie en Embryologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: GROW - School for Oncology and Reproduction, and Other departments

Subjects
Mouth neoplasm, medicine.medical_specialty, Immunoperoxidase, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Arbitrary unit, Mutagen, Cheek, medicine.disease_cause, Gastroenterology, chemistry.chemical_compound, stomatognathic diseases, medicine.anatomical_structure, Tar (tobacco residue), Benzo(a)pyrene, chemistry, stomatognathic system, Internal medicine, Medicine, business, Genetics (clinical), Carcinogen
Abstract

Tobacco smoking is a major risk factor for oral cancer; mouth floor and buccal mucosa are among the most and least cancer-prone subsites, respectively, in the oral cavity. We investigated the applicability of immunohistochemistry of smoking-induced DNA adducts in oral cells for assessing the exposure to carcinogens, and estimating the risk for oral cancer. Polycyclic aromatic hydrocarbon (PAH)-DNA adducts were measured in mouth floor and buccal mucosa cells of smokers (n = 26) and nonsmokers (n = 22) by means of a semiquantitative immunoperoxidase assay. Smokers had elevated levels of PAH-DNA adducts compared to nonsmokers in their mouth floor cells (0.045 ± 0.022 versus 0.022 ± 0.016, P = 0.0008 arbitrary units of immunohistochemistry) as well as in their buccal mucosa cells (0.058 ± 0.028 versus 0.028 ± 0.012, P = 0.001). Also, there was a correlation between the levels of PAH-DNA adducts in mouth floor cells and those in buccal mucosa cells (r = 0.4, P = 0.01). Furthermore, PAH-DNA adduct levels in both mouth floor and buccal mucosa cells were significantly related to current smoking indices (amount of tar and number of cigarettes consumed per day). Expectedly, the levels of PAH-DNA adducts neither in mouth floor cells nor in buccal mucosa cells, both being short-lived cells, were related to smoking history index (pack years). The levels of PAH-DNA adducts, however, in mouth floor cells as the cancer prone cells were lower than those in buccal mucosa cells (0.037 ± 0.023 versus 0.044 ± 0.026, P = 0.04). We conclude that immunohistochemistry of PAH-DNA adducts in oral cells can be used for exposure assessment of tobacco-related carcinogens, however, it cannot be used for oral cancer risk estimation. Environ. Mol. Mutagen. 36:127–133, 2000. © 2000 Wiley-Liss, Inc.

Published
2000

35. Abstracts of papers

Author

Vercammen-Grandjean, A., Renoux, G., Vermeulen, N. P. E., van Bree, L., de Vries, J., Commandeur, J., Lamberts, B. B., Redegeld, F. A. M., van Schooten, F. -J., Scholte, B. J., de Vries, J., Groot, G. S. P., Laduron, Pierre M., and Blankenstein, M. A.

Published
1983
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36. Abstracts of papers Toxicological meeting

Author

Breukink, H. J., Baars, A. J., Vroomen, L. H. M., Jager, L. P., Korstanje, C., Witkamp, R. J., van Leeuwen, F. X. R., Boogaard, P. J., Zoeteweij, J. P., Mulder, G. J., Nagelkerke, J. F., Bos, R. P., Kromhout, H., Ikink, H., Theuws, J. L. G., Dentener, M. A., Maessen, J. G., Buurman, W. A., de Vries, H., Bojarski, J., van Henegouwen, G. M. J. Beijersbergen, de Wolff, F. A., van Welsum, R. A., Marani, E., van Keep, J. P., van der Voet, G. B., den Besten, P. J., Livingstone, D. R., Dogterom, P., Evelo, C. T. A., Fijneman, P. H. S., Pötgens, A. J. G., Furnée, Carina, Verhagen, Hans, Schutte, Bert, Reynders, Michèle M. J., Blijham, Geert H., ten Hoor, Foppe, Kieinjans, Jos C. S., Haenen, G. R. M. M., Bast, A., Hageman, Geja, Kjkken, Rene, Kleinjans, Jos, Welle, Irene, Hajee, C. A. J., Rietveld, E. C., Seutter-Berlage, F., Hoogenboom, L. A. P., van Vliet, T., Kuiper, H. A., Canssen, Y., Hageman, G., van Agen, B., Schreurs, J., Jongeneelen, F. J., van Schooten, F. J., Kriek, E., van Leeuwen, F., Kelder, P. P., Dubbeling, M., de Mol, N. J., Janssen, L. H. M., Koymans, Luc, van Lenthe, Joop H., van de Straat, Ronald, den Kelder, Gabriëlle M. Donn-Op, Vermeulen, Nico P. E., Luyckx, Niels B. Lucas, Mennes, Wim C., van Pelt, Frank N. A. M., Noordhoek, Jan, Blaauboer, Bas J., Lusthof, K. J., Richter, W., Mannes, Wim C., van Holsteijn, Ineke W. M., Spierenburg, Th. J., van der Molen, E. J., de Graaf, G. J., Jager, L. P., Spierenburo, Th. J., Jager, L. P., Brus, D. H. J., Tielen, M. J. M., Arts, B. J., Stijntjes, G. J., Vermeulen, N. P. E., ten Hoor, F., ten Kate, J., Moerkerk, P., Bosman, F., Kleinjans, J., van Benthem, J., Wilmer, J. W. G. M., Leeman, U. R., Winterwerp, H. H. K., den Engelse, L., Scherer, E., van Bree, L., Rietjens, I. M. C. M., Verhoef, M. A., de Boer, R., Muller, J. J. A., Dormans, J. A. M. A., Rombout, P. J. A., van de Poll, M. L. M., van der Hulst, O. A. M., Tates, A. D., Meerman, J. H. N., van de Wiel, J. A. G., Duyf, C. M. P., Bos, P. P., Verweij, P. E., Sips, A., van Erp, Yvette H. H., Heirbaut, Petra R. C. M., Koopmans, Marion J. E., Weterings, Peter J. J. M., van Ginkel, M. F., van der Voet, E. V., van Loveren, H., Blommaert, F. A., Krajnc, E. I., Vos, J. G., van Ommen, Ben, Bogaards, Jan, van Bladeren, Peter J., van der Heijden, Ruud M., Hassing, Ine G. A. M., van Welie, R. T. H., van Duyn, P., Beckers, Rico H. G., Kleinjans, Jos C. S., and Maas, Lou M.

Published
1989
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42. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

Author

Godschalk, R. W. L., primary, Ersson, C., additional, St pnik, M., additional, Ferli ska, M., additional, Palus, J., additional, Teixeira, J. P., additional, Costa, S., additional, Jones, G. D. D., additional, Higgins, J. A., additional, Kain, J., additional, Moller, L., additional, Forchhammer, L., additional, Loft, S., additional, Lorenzo, Y., additional, Collins, A. R., additional, van Schooten, F.-J., additional, Laffon, B., additional, Valdiglesias, V., additional, Cooke, M., additional, Mistry, V., additional, Karbaschi, M., additional, Phillips, D. H., additional, Sozeri, O., additional, Routledge, M. N., additional, Nelson-Smith, K., additional, Riso, P., additional, Porrini, M., additional, Lopez de Cerain, A., additional, Azqueta, A., additional, Matullo, G., additional, Allione, A., additional, and Moller, P., additional

Published
2014
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45. An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells

Author

Ersson, C., primary, Moller, P., additional, Forchhammer, L., additional, Loft, S., additional, Azqueta, A., additional, Godschalk, R. W. L., additional, van Schooten, F.-J., additional, Jones, G. D. D., additional, Higgins, J. A., additional, Cooke, M. S., additional, Mistry, V., additional, Karbaschi, M., additional, Phillips, D. H., additional, Sozeri, O., additional, Routledge, M. N., additional, Nelson-Smith, K., additional, Riso, P., additional, Porrini, M., additional, Matullo, G., additional, Allione, A., additional, Stepnik, M., additional, Ferlinska, M., additional, Teixeira, J. P., additional, Costa, S., additional, Corcuera, L.-A., additional, Lopez de Cerain, A., additional, Laffon, B., additional, Valdiglesias, V., additional, Collins, A. R., additional, and Moller, L., additional

Published
2013
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47. Exhaled breath profiling in diagnosing wheezy preschool children

Author

van de Kant, K. D. G., primary, van Berkel, J. J. B. N., additional, Jobsis, Q., additional, Lima Passos, V., additional, Klaassen, E. M. M., additional, van der Sande, L., additional, van Schayck, O. C. P., additional, de Jongste, J. C., additional, van Schooten, F. J., additional, Derks, E., additional, Dompeling, E., additional, and Dallinga, J. W., additional

Published
2012
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