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Your search keyword '"van Scherpenzeel, Revina C."' showing total 8 results
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8 results on '"van Scherpenzeel, Revina C."'

4. Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Author

CMM Groep Maurice, Regenerative Medicine and Stem Cells, Cancer, Fenderico, Nicola, van Scherpenzeel, Revina C., Goldflam, Michael, Proverbio, Davide, Jordens, Ingrid, Kralj, Tomica, Stryeck, Sarah, Bass, Tarek Z., Hermans, Guy, Ullman, Christopher, Aastrup, Teodor, Gros, Piet, Maurice, Madelon M., CMM Groep Maurice, Regenerative Medicine and Stem Cells, Cancer, Fenderico, Nicola, van Scherpenzeel, Revina C., Goldflam, Michael, Proverbio, Davide, Jordens, Ingrid, Kralj, Tomica, Stryeck, Sarah, Bass, Tarek Z., Hermans, Guy, Ullman, Christopher, Aastrup, Teodor, Gros, Piet, and Maurice, Madelon M.

Published
2019

5. Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Author

Sub NMR Spectroscopy, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Cellular Protein Chemistry, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics, Cellular Protein Chemistry, Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D, Maurice, Madelon M, Sub NMR Spectroscopy, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Cellular Protein Chemistry, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics, Cellular Protein Chemistry, Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D, and Maurice, Madelon M

Published
2016

6. Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Author

NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics, Cellular Protein Chemistry, Sub NMR Spectroscopy, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Cellular Protein Chemistry, Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D, Maurice, Madelon M, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics, Cellular Protein Chemistry, Sub NMR Spectroscopy, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Cellular Protein Chemistry, Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D, and Maurice, Madelon M

Published
2016

7. Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Author

CMM Groep Maurice, CMM Groep Burgering, Regenerative Medicine and Stem Cells, Cancer, Anvarian, Zeinab, Nojima, Hisashi, Van Kappel, Eline C., Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y., Van Scherpenzeel, Revina C., Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean Paul, Rüdiger, Stefan G D, Maurice, Madelon M., CMM Groep Maurice, CMM Groep Burgering, Regenerative Medicine and Stem Cells, Cancer, Anvarian, Zeinab, Nojima, Hisashi, Van Kappel, Eline C., Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y., Van Scherpenzeel, Revina C., Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean Paul, Rüdiger, Stefan G D, and Maurice, Madelon M.

Published
2016

8. A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein.

Author

Ballegeer M, van Scherpenzeel RC, Delgado T, Iglesias-Caballero M, García Barreno B, Pandey S, Rush SA, Kolkman JA, Mas V, McLellan JS, and Saelens X

Subjects
Humans, Antibodies, Viral, Antibodies, Neutralizing, Epitopes, Viral Fusion Proteins metabolism, Metapneumovirus genetics, Metapneumovirus metabolism, Single-Domain Antibodies
Abstract

Importance: Human metapneumovirus (hMPV) is an important respiratory pathogen for which no licensed antivirals or vaccines exist. Single-domain antibodies represent promising antiviral biologics that can be easily produced and formatted. We describe the isolation and detailed characterization of two hMPV-neutralizing single-domain antibodies that are directed against the fusion protein F. One of these single-domain antibodies broadly neutralizes hMPV A and B strains, can prevent proteolytic maturation of F, and binds to an epitope in the F trimer interface. This suggests that hMPV pre-F undergoes trimer opening or "breathing" on infectious virions, exposing a vulnerable site for neutralizing antibodies. Finally, we show that this single-domain antibody, fused to a human IgG1 Fc, can protect cotton rats against hMPV replication, an important finding for potential future clinical applications., Competing Interests: This work was supported by a grant from Janssen Pharmaceuticals Inc. to X.S.

Published
2024
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