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This work proposes a fairness monitoring approach for machine learning models that predict patient mortality in the ICU. We investigate how well models perform for patient groups with different race, sex and medical diagnoses. We investigate Documentation bias in clinical measurement, showing how fairness analysis provides a more detailed and insightful comparison of model performance than traditional accuracy metrics alone., Comment: 8 pages

Estimated brain age from magnetic resonance image (MRI) and its deviation from chronological age can provide early insights into potential neurodegenerative diseases, supporting early detection and implementation of prevention strategies. Diffusion MRI (dMRI), a widely used modality for brain age estimation, presents an opportunity to build an earlier biomarker for neurodegenerative disease prediction because it captures subtle microstructural changes that precede more perceptible macrostructural changes. However, the coexistence of macro- and micro-structural information in dMRI raises the question of whether current dMRI-based brain age estimation models are leveraging the intended microstructural information or if they inadvertently rely on the macrostructural information. To develop a microstructure-specific brain age, we propose a method for brain age identification from dMRI that minimizes the model's use of macrostructural information by non-rigidly registering all images to a standard template. Imaging data from 13,398 participants across 12 datasets were used for the training and evaluation. We compare our brain age models, trained with and without macrostructural information minimized, with an architecturally similar T1-weighted (T1w) MRI-based brain age model and two state-of-the-art T1w MRI-based brain age models that primarily use macrostructural information. We observe difference between our dMRI-based brain age and T1w MRI-based brain age across stages of neurodegeneration, with dMRI-based brain age being older than T1w MRI-based brain age in participants transitioning from cognitively normal (CN) to mild cognitive impairment (MCI), but younger in participants already diagnosed with Alzheimer's disease (AD). Approximately 4 years before MCI diagnosis, dMRI-based brain age yields better performance than T1w MRI-based brain ages in predicting transition from CN to MCI.

Rapid detection of gas concentration is important in different domains like gas leakage monitoring, pollution control, and so on, for the prevention of health hazards. Out of different types of gas sensors, Metal oxide (MOx) sensors are extensively used in such applications because of their portability, low cost, and high sensitivity for specific gases. However, how to effectively sample the MOx data for the real-time detection of gas and its concentration level remains an open question. Here we introduce a simple analog front-end for one MOx sensor that encodes the gas concentration in the time difference between pulses of two separate pathways. This front-end design is inspired by the spiking output of a mammalian olfactory bulb. We show that for a gas pulse injected in a constant airflow, the time difference between pulses decreases with increasing gas concentration, similar to the spike time difference between the two principal output neurons in the olfactory bulb. The circuit design is further extended to a MOx sensor array and this sensor array front-end was tested in the same environment for gas identification and concentration estimation. Encoding of gas stimulus features in analog spikes at the sensor level itself may result in data and power-efficient real-time gas sensing systems in the future that can ultimately be used in uncontrolled and turbulent environments for longer periods without data explosion.

Accurate musculoskeletal soft tissue tumor segmentation is vital for assessing tumor size, location, diagnosis, and response to treatment, thereby influencing patient outcomes. However, segmentation of these tumors requires clinical expertise, and an automated segmentation model would save valuable time for both clinician and patient. Training an automatic model requires a large dataset of annotated images. In this work, we describe the collection of an MR imaging dataset of 199 musculoskeletal soft tissue tumors from 199 patients. We trained segmentation models on this dataset and then benchmarked them on a publicly available dataset. Our model achieved the state-of-the-art dice score of 0.79 out of the box without any fine tuning, which shows the diversity and utility of our curated dataset. We analyzed the model predictions and found that its performance suffered on fibrous and vascular tumors due to their diverse anatomical location, size, and intensity heterogeneity. The code and models are available in the following github repository, https://github.com/Reasat/mstt, Comment: Dataset will be made publicly available after the acceptance of the paper

For Edge AI applications, deploying online learning and adaptation on resource-constrained embedded devices can deal with fast sensor-generated streams of data in changing environments. However, since maintaining low-latency and power-efficient inference is paramount at the Edge, online learning and adaptation on the device should impose minimal additional overhead for inference. With this goal in mind, we explore energy-efficient learning and adaptation on-device for streaming-data Edge AI applications using Spiking Neural Networks (SNNs), which follow the principles of brain-inspired computing, such as high-parallelism, neuron co-located memory and compute, and event-driven processing. We propose EON-1, a brain-inspired processor for near-sensor extreme edge online feature extraction, that integrates a fast online learning and adaptation algorithm. We report results of only 1% energy overhead for learning, by far the lowest overhead when compared to other SoTA solutions, while attaining comparable inference accuracy. Furthermore, we demonstrate that EON-1 is up for the challenge of low-latency processing of HD and UHD streaming video in real-time, with learning enabled.

Animals have evolved to rapidly detect and recognise brief and intermittent encounters with odour packages, exhibiting recognition capabilities within milliseconds. Artificial olfaction has faced challenges in achieving comparable results -- existing solutions are either slow; or bulky, expensive, and power-intensive -- limiting applicability in real-world scenarios for mobile robotics. Here we introduce a miniaturised high-speed electronic nose; characterised by high-bandwidth sensor readouts, tightly controlled sensing parameters and powerful algorithms. The system is evaluated on a high-fidelity odour delivery benchmark. We showcase successful classification of tens-of-millisecond odour pulses, and demonstrate temporal pattern encoding of stimuli switching with up to 60 Hz. Those timescales are unprecedented in miniaturised low-power settings, and demonstrably exceed the performance observed in mice. For the first time, it is possible to match the temporal resolution of animal olfaction in robotic systems. This will allow for addressing challenges in environmental and industrial monitoring, security, neuroscience, and beyond.

Imaging findings inconsistent with those expected at specific chronological age ranges may serve as early indicators of neurological disorders and increased mortality risk. Estimation of chronological age, and deviations from expected results, from structural MRI data has become an important task for developing biomarkers that are sensitive to such deviations. Complementary to structural analysis, diffusion tensor imaging (DTI) has proven effective in identifying age-related microstructural changes within the brain white matter, thereby presenting itself as a promising additional modality for brain age prediction. Although early studies have sought to harness DTI's advantages for age estimation, there is no evidence that the success of this prediction is owed to the unique microstructural and diffusivity features that DTI provides, rather than the macrostructural features that are also available in DTI data. Therefore, we seek to develop white-matter-specific age estimation to capture deviations from normal white matter aging. Specifically, we deliberately disregard the macrostructural information when predicting age from DTI scalar images, using two distinct methods. The first method relies on extracting only microstructural features from regions of interest. The second applies 3D residual neural networks (ResNets) to learn features directly from the images, which are non-linearly registered and warped to a template to minimize macrostructural variations. When tested on unseen data, the first method yields mean absolute error (MAE) of 6.11 years for cognitively normal participants and MAE of 6.62 years for cognitively impaired participants, while the second method achieves MAE of 4.69 years for cognitively normal participants and MAE of 4.96 years for cognitively impaired participants. We find that the ResNet model captures subtler, non-macrostructural features for brain age prediction., Comment: SPIE Medical Imaging: Image Processing. San Diego, CA. February 2024 (accepted as poster presentation)

This article introduces the Event based Prediction Suffix Tree (EPST), a biologically inspired, event-based prediction algorithm. The EPST learns a model online based on the statistics of an event based input and can make predictions over multiple overlapping patterns. The EPST uses a representation specific to event based data, defined as a portion of the power set of event subsequences within a short context window. It is explainable, and possesses many promising properties such as fault tolerance, resistance to event noise, as well as the capability for one-shot learning. The computational features of the EPST are examined in a synthetic data prediction task with additive event noise, event jitter, and dropout. The resulting algorithm outputs predicted projections for the near term future of the signal, which may be applied to tasks such as event based anomaly detection or pattern recognition.

Gas concentration detection is important for applications such as gas leakage monitoring. Metal Oxide (MOx) sensors show high sensitivities for specific gases, which makes them particularly useful for such monitoring applications. However, how to efficiently sample and further process the sensor responses remains an open question. Here we propose a simple analog circuit design inspired by the spiking output of the mammalian olfactory bulb and by event-based vision sensors. Our circuit encodes the gas concentration in the time difference between the pulses of two separate pathways. We show that in the setting of controlled airflow-embedded gas injections, the time difference between the two generated pulses varies inversely with gas concentration, which is in agreement with the spike timing difference between tufted cells and mitral cells of the mammalian olfactory bulb. Encoding concentration information in analog spike timings may pave the way for rapid and efficient gas detection, and ultimately lead to data- and power-efficient monitoring devices to be deployed in uncontrolled and turbulent environments., Comment: \c{opyright} 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

Neuromorphic computing is one of the few current approaches that have the potential to significantly reduce power consumption in Machine Learning and Artificial Intelligence. Imam & Cleland presented an odour-learning algorithm that runs on a neuromorphic architecture and is inspired by circuits described in the mammalian olfactory bulb. They assess the algorithm's performance in "rapid online learning and identification" of gaseous odorants and odorless gases (short "gases") using a set of gas sensor recordings of different odour presentations and corrupting them by impulse noise. We replicated parts of the study and discovered limitations that affect some of the conclusions drawn. First, the dataset used suffers from sensor drift and a non-randomised measurement protocol, rendering it of limited use for odour identification benchmarks. Second, we found that the model is restricted in its ability to generalise over repeated presentations of the same gas. We demonstrate that the task the study refers to can be solved with a simple hash table approach, matching or exceeding the reported results in accuracy and runtime. Therefore, a validation of the model that goes beyond restoring a learned data sample remains to be shown, in particular its suitability to odour identification tasks., Comment: 8 pages, 4 figures

Deep Neural Network (DNN) based inference at the edge is challenging as these compute and data-intensive algorithms need to be implemented at low cost and low power while meeting the latency constraints of the target applications. Sparsity, in both activations and weights inherent to DNNs, is a key knob to leverage. In this paper, we present RAMAN, a Re-configurable and spArse tinyML Accelerator for infereNce on edge, architected to exploit the sparsity to reduce area (storage), power as well as latency. RAMAN can be configured to support a wide range of DNN topologies - consisting of different convolution layer types and a range of layer parameters (feature-map size and the number of channels). RAMAN can also be configured to support accuracy vs power/latency tradeoffs using techniques deployed at compile-time and run-time. We present the salient features of the architecture, provide implementation results and compare the same with the state-of-the-art. RAMAN employs novel dataflow inspired by Gustavson's algorithm that has optimal input activation (IA) and output activation (OA) reuse to minimize memory access and the overall data movement cost. The dataflow allows RAMAN to locally reduce the partial sum (Psum) within a processing element array to eliminate the Psum writeback traffic. Additionally, we suggest a method to reduce peak activation memory by overlapping IA and OA on the same memory space, which can reduce storage requirements by up to 50%. RAMAN was implemented on a low-power and resource-constrained Efinix Ti60 FPGA with 37.2K LUTs and 8.6K register utilization. RAMAN processes all layers of the MobileNetV1 model at 98.47 GOp/s/W and the DS-CNN model at 79.68 GOp/s/W by leveraging both weight and activation sparsity.

This paper presents an efficient hardware implementation of the recently proposed Optimized Deep Event-driven Spiking Neural Network Architecture (ODESA). ODESA is the first network to have end-to-end multi-layer online local supervised training without using gradients and has the combined adaptation of weights and thresholds in an efficient hierarchical structure. This research shows that the network architecture and the online training of weights and thresholds can be implemented efficiently on a large scale in hardware. The implementation consists of a multi-layer Spiking Neural Network (SNN) and individual training modules for each layer that enable online self-learning without using back-propagation. By using simple local adaptive selection thresholds, a Winner-Takes-All (WTA) constraint on each layer, and a modified weight update rule that is more amenable to hardware, the trainer module allocates neuronal resources optimally at each layer without having to pass high-precision error measurements across layers. All elements in the system, including the training module, interact using event-based binary spikes. The hardware-optimized implementation is shown to preserve the performance of the original algorithm across multiple spatial-temporal classification problems with significantly reduced hardware requirements., Comment: 15 Pages, 19 Figures

The drive to create thinner, lighter, and more energy efficient devices has resulted in modern SoCs being forced to balance a delicate tradeoff between power consumption, heat dissipation, and execution speed (i.e., frequency). While beneficial, these DVFS mechanisms have also resulted in software-visible hybrid side-channels, which use software to probe analog properties of computing devices. Such hybrid attacks are an emerging threat that can bypass countermeasures for traditional microarchitectural side-channel attacks. Given the rise in popularity of both Arm SoCs and GPUs, in this paper we investigate the susceptibility of these devices to information leakage via power, temperature and frequency, as measured via internal sensors. We demonstrate that the sensor data observed correlates with both instructions executed and data processed, allowing us to mount software-visible hybrid side-channel attacks on these devices. To demonstrate the real-world impact of this issue, we present JavaScript-based pixel stealing and history sniffing attacks on Chrome and Safari, with all side channel countermeasures enabled. Finally, we also show website fingerprinting attacks, without any elevated privileges.

Neuromorphic computing shows promise for advancing computing efficiency and capabilities of AI applications using brain-inspired principles. However, the neuromorphic research field currently lacks standardized benchmarks, making it difficult to accurately measure technological advancements, compare performance with conventional methods, and identify promising future research directions. Prior neuromorphic computing benchmark efforts have not seen widespread adoption due to a lack of inclusive, actionable, and iterative benchmark design and guidelines. To address these shortcomings, we present NeuroBench: a benchmark framework for neuromorphic computing algorithms and systems. NeuroBench is a collaboratively-designed effort from an open community of nearly 100 co-authors across over 50 institutions in industry and academia, aiming to provide a representative structure for standardizing the evaluation of neuromorphic approaches. The NeuroBench framework introduces a common set of tools and systematic methodology for inclusive benchmark measurement, delivering an objective reference framework for quantifying neuromorphic approaches in both hardware-independent (algorithm track) and hardware-dependent (system track) settings. In this article, we present initial performance baselines across various model architectures on the algorithm track and outline the system track benchmark tasks and guidelines. NeuroBench is intended to continually expand its benchmarks and features to foster and track the progress made by the research community., Comment: Updated from whitepaper to full perspective article preprint

Sparse and event-driven spiking neural network (SNN) algorithms are the ideal candidate solution for energy-efficient edge computing. Yet, with the growing complexity of SNN algorithms, it isn't easy to properly benchmark and optimize their computational cost without hardware in the loop. Although digital neuromorphic processors have been widely adopted to benchmark SNN algorithms, their black-box nature is problematic for algorithm-hardware co-optimization. In this work, we open the black box of the digital neuromorphic processor for algorithm designers by presenting the neuron processing instruction set and detailed energy consumption of the SENeCA neuromorphic architecture. For convenient benchmarking and optimization, we provide the energy cost of the essential neuromorphic components in SENeCA, including neuron models and learning rules. Moreover, we exploit the SENeCA's hierarchical memory and exhibit an advantage over existing neuromorphic processors. We show the energy efficiency of SNN algorithms for video processing and online learning, and demonstrate the potential of our work for optimizing algorithm designs. Overall, we present a practical approach to enable algorithm designers to accurately benchmark SNN algorithms and pave the way towards effective algorithm-hardware co-design.

This paper presents a reconfigurable digital implementation of an event-based binaural cochlear system on a Field Programmable Gate Array (FPGA). It consists of a pair of the Cascade of Asymmetric Resonators with Fast Acting Compression (CAR FAC) cochlea models and leaky integrate and fire (LIF) neurons. Additionally, we propose an event-driven SpectroTemporal Receptive Field (STRF) Feature Extraction using Adaptive Selection Thresholds (FEAST). It is tested on the TIDIGTIS benchmark and compared with current event-based auditory signal processing approaches and neural networks., Comment: 12 pages, 8 figures

As an emerging approach to space situational awareness and space imaging, the practical use of an event-based camera in space imaging for precise source analysis is still in its infancy. The nature of event-based space imaging and data collection needs to be further explored to develop more effective event-based space image systems and advance the capabilities of event-based tracking systems with improved target measurement models. Moreover, for event measurements to be meaningful, a framework must be investigated for event-based camera calibration to project events from pixel array coordinates in the image plane to coordinates in a target resident space object's reference frame. In this paper, the traditional techniques of conventional astronomy are reconsidered to properly utilise the event-based camera for space imaging and space situational awareness. This paper presents the techniques and systems used for calibrating an event-based camera for reliable and accurate measurement acquisition. These techniques are vital in building event-based space imaging systems capable of real-world space situational awareness tasks. By calibrating sources detected using the event-based camera, the spatio-temporal characteristics of detected sources or `event sources' can be related to the photometric characteristics of the underlying astrophysical objects. Finally, these characteristics are analysed to establish a foundation for principled processing and observing techniques which appropriately exploit the capabilities of the event-based camera.

We describe the solution of an optimal stopping problem for a stable L\'evy process killed at state-dependent rate, which can be seen as a model for bankruptcy. The killing rate is chosen in such a way that the killed process remains self-similar, and the solution to the optimal stopping problem is obtained by characterising a self-similar Markov process associated with the stable process. The optimal stopping strategy is to stop upon first passage into an interval, found explicitly in terms of the parameters of the model., Comment: 25 pages