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2. Epidemiology, Outcomes, and Complement Gene Variants in Secondary Thrombotic Microangiopathies

Author

Werion, Alexis, Storms, Pauline, Zizi, Ysaline, Beguin, Claire, Bernards, Jelle, Cambier, Jean-François, Dahan, Karin, Dierickx, Daan, Godefroid, Nathalie, Hilbert, Pascale, Lambert, Catherine, Levtchenko, Elena, Meyskens, Thomas, Poiré, Xavier, van den Heuvel, Lambert, Claes, Kathleen J., Morelle, Johann, Aydin, Selda, Cuvelier, Charles, Decleire, Pierre-Yves, Demoulin, Nathalie, Devresse, Arnaud, Gérard, Ludovic, Gillerot, Gaëlle, Gillion, Valentine, Goffin, Eric, Hantson, Philippe, Jadoul, Michel, Jamez, Jean, Kanaan, Nada, Labriola, Laura, Lengelé, Jean-Philippe, Mazzoleni, Lionel, Pirson, Yves, Pochet, Jean-Michel, Ranguelov, Nadejda, van Dievoet, Marie-Astrid, van Regemorter, Elliott, Wittebole, Xavier, all the collaborators of UCLouvain Kidney Disease Network, Bammens, Bert, de Vlieger, Greet, Devriendt, Koenraad, de Vusser, Katrien, Evenepoel, Pieter, Godinas, Laurent, Koshy, Priyanka, Kuypers, Dirk, Lerut, Evelyne, Meijers, Björn, Naesens, Maartens, Schöffski, Patrick, Sprangers, Ben, Timmerman, Dirk, van Craenenbroeck, Amaryllis, Wilmer, Alexander, and all the collaborators/nephrologists from the Leuvense Samenwerkende Groep voor Nefrologen (LSGN)

Published
2023
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4. PKD1 mosaicism associated with severe renal, hepatic, and vascular phenotype

Author

Van Regemorter, Elliott, Dahan, Karin, Hougardy, Charlotte, Ciccarelli, Olga, Kanaan, Nada, Pirson, Yves, Demoulin, Nathalie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, and UCL - SSS/IREC - Institut de recherche expérimentale et clinique

Subjects
Nephrology, General Medicine
Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by mutations in or genes. Mosaicism is characterized by a post-zygotic mutation resulting in the presence of two or more populations of cells with different genotypes in an individual. Mosaicism of , rarely identified by conventional Sanger sequencing, is more easily detected using next generation sequencing techniques (NGS). mosaicism has classically been associated with either milder kidney disease, asymmetric kidney disease, and/or negative family history. We report the case of a patient presenting severe renal, hepatic, and vascular phenotype secondary to mosaicism, with a surprisingly low percentage of mutant allele in the patient's kidney and liver tissue. We reviewed clinical presentations of reported cases of mosaicism.

Published
2022
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5. Quiz: A Case of Acute Intravascular Hemolysis During Dialysis: A Quiz.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Dufour, Inès, Briol, Sébastien, Van Regemorter, Elliott, Goffin, Eric, Devresse, Arnaud, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Dufour, Inès, Briol, Sébastien, Van Regemorter, Elliott, Goffin, Eric, and Devresse, Arnaud

Published
2023

7. Humoral responses to BNT162b2 SARS-CoV-2 and hepatitis B vaccines are associated in patients on maintenance hemodialysis: a single-centre experience in Belgium.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Van Regemorter, Elliott, Scohy, Anais, Morelle, Johann, Jadoul, Michel, Labriola, Laura, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Van Regemorter, Elliott, Scohy, Anais, Morelle, Johann, Jadoul, Michel, and Labriola, Laura

Published
2022

8. PKD1 mosaicism associated with severe renal, hepatic, and vascular phenotype.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Van Regemorter, Elliott, Dahan, Karin, Hougardy, Charlotte, Ciccarelli, Olga, Kanaan, Nada, Pirson, Yves, Demoulin, Nathalie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Van Regemorter, Elliott, Dahan, Karin, Hougardy, Charlotte, Ciccarelli, Olga, Kanaan, Nada, Pirson, Yves, and Demoulin, Nathalie

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by mutations in or genes. Mosaicism is characterized by a post-zygotic mutation resulting in the presence of two or more populations of cells with different genotypes in an individual. Mosaicism of , rarely identified by conventional Sanger sequencing, is more easily detected using next generation sequencing techniques (NGS). mosaicism has classically been associated with either milder kidney disease, asymmetric kidney disease, and/or negative family history. We report the case of a patient presenting severe renal, hepatic, and vascular phenotype secondary to mosaicism, with a surprisingly low percentage of mutant allele in the patient's kidney and liver tissue. We reviewed clinical presentations of reported cases of mosaicism.

Published
2022

11. Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine in a Multicenter Cohort of Nursing Home Residents Receiving Maintenance Hemodialysis.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de médecine interne générale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba, Benoît, Rodriguez-Villalobos, Hector, Jadoul, Michel, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de médecine interne générale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba, Benoît, Rodriguez-Villalobos, Hector, and Jadoul, Michel

Published
2021

12. Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine in a Multicenter Cohort of Nursing Home Residents Receiving Maintenance Hemodialysis

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba-Mukadi, Benoît, Rodriguez-Villalobos, Hector, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba-Mukadi, Benoît, Rodriguez-Villalobos, Hector, and Jadoul, Michel

Published
2021

13. Humoral responses to BNT162b2 SARS-CoV-2 and hepatitis B vaccines are associated in patients on maintenance hemodialysis: a single-center experience in Belgium

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Van Regemorter, Elliott, Scohy, Anaïs, Morelle, Johann, Jadoul, Michel, Labriola, Laura, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Van Regemorter, Elliott, Scohy, Anaïs, Morelle, Johann, Jadoul, Michel, and Labriola, Laura

Published
2021

14. Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1α Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes

Author

Van Regemorter, Elliott, primary, Joris, Virginie, additional, Van Regemorter, Victoria, additional, Marique, Lancelot, additional, Behets, Catherine, additional, Lengelé, Benoit, additional, Boschi, Antonella, additional, Baldeschi, Lelio, additional, Daumerie, Chantal, additional, Many, Marie-Christine, additional, and Craps, Julie, additional

Published
2021
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16. Oxidative Stress and Upregulation of Antioxidant Proteins, Including Adiponectin, in Extraocular Muscular Cells, Orbital Adipocytes, and Thyrocytes in Graves' Disease Associated with Orbitopathy

Author

Marique, Lancelot, primary, Senou, Maximin, additional, Craps, Julie, additional, Delaigle, Aurélie, additional, Van Regemorter, Elliott, additional, Wérion, Alexis, additional, Van Regemorter, Victoria, additional, Mourad, Michel, additional, Nyssen-Behets, Catherine, additional, Lengelé, Benoit, additional, Baldeschi, Lelio, additional, Boschi, Antonella, additional, Brichard, Sonia, additional, Daumerie, Chantal, additional, and Many, Marie-Christine, additional

Published
2015
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17. Bridging the Gap Between CKD Management Paradigms in Transplant and Nontransplant Settings: Published Evidence, Challenges, and Perspectives.

Author

Dufour I, Van Regemorter E, Kanaan N, Buemi A, Darius T, Mourad M, Goffin E, Jadoul M, Devresse A, and Gillion V

Abstract

Kidney transplantation (KT) is the best treatment for patients with kidney failure, associated with improved survival and quality of life compared with maintenance dialysis. However, despite constant improvements in the assessment and management of the alloimmune response, KT patients frequently demonstrate a reduced estimated glomerular filtration rate. Therefore, the usual complications of chronic kidney disease (CKD), such as anemia, hypertension, metabolic acidosis, hyperkalemia, or persistent secondary hyperparathyroidism, are highly prevalent after KT. However, their underlying mechanisms are different in the transplant setting (compared with the nontransplanted CKD population), and management recommendations are based on relatively poor-quality data. In recent years, new therapies have emerged, significantly improving kidney and cardiovascular outcomes of non-KT patients with CKD. Whether those new drugs could improve the outcomes of KT patients has largely been under investigated so far. In this review, we will address the challenges of the management of a KT patient with a reduced estimated glomerular filtration rate, cover the published evidence, and highlight the critical knowledge gaps., Competing Interests: T.D. reports research support from the Fonds National de Recherche Scientifique – FNRS (F.R.S.-FNRS) as well as travel support from Organ Recovery Systems, Diegem, Belgium. E.G. reports research support from Baxter Healthcare, conference support from Baxter Healthcare, Fresenius, Nx Stage, Dirinco, and AstraZeneca; and consulting fees from Amgen, Astellas, AstraZeneca, Bayer, Baxter Healthcare, Fresenius, NxStage, and Dirinco. M.J. reports research support from AstraZeneca, speaker fees from AstraZeneca, Bayer, Boehringer-Ingelheim, and Menarini; consulting fees from Astellas, AstraZeneca, Bayer, Boehringer-Ingelheim, Cardiorenal, CSL Vifor, GlaxoSmithKline, Stada-Eurogenerics, and Vertex; and other: co-chair of Kidney Disease Improving Global Outcomes (KDIGO) since January 2019. A.D. reports consultancy fees from Alnylam and Merck. E.V.R. reports support from CSL Vifor and Pharmacosmos; speaker fees from Baxter Healthcare, Astellas, and Bayer; and consulting fees from Bayer. N.K. reports consulting fees from Hansa Biopharm. The other authors declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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