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150 results on '"van Nunen, Lokien"'

1. Upper extremity versus lower extremity for secondary access during transcatheter aortic valve implantation: rationale and design of the randomised TAVI XS trial

Author

Rooijakkers, Maxim J. P., Versteeg, Geert A. A., Hemelrijk, Kimberley I., Aarts, Hugo M., Overduin, Daniël C., van Ginkel, Dirk-Jan, Vlaar, Pieter J., van Wely, Marleen H., van Nunen, Lokien X., van Geuns, Robert Jan, van Garsse, Leen A. F. M., Geuzebroek, Guillaume S. C., Verkroost, Michel W. A., Rodwell, Laura, Heijmen, Robin H., Tonino, Pim A. L., ten Berg, Jurrien M., Delewi, Ronak, and van Royen, Niels

Published
2024
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2. Functional and morphological improvement of significant non-culprit coronary artery stenosis by LDL-C reduction with a PCSK9 antibody: Rationale and design of the randomized FITTER trial

Author

Mensink, Frans B., Los, Jonathan, Oemrawsingh, Rohit M., von Birgelen, Clemens, Ijsselmuiden, Alexander, Meuwissen, Martijn, Cheng, Jin M., van Wijk, Diederik F., Smits, Pieter C., Paradies, Valeria, van der Heijden, Dirk J., Rai, Himanshu, ten Cate, Tim JF., Camaro, Cyril, Damman, Peter, van Nunen, Lokien X., Dimitriu-Leen, Aukelien C., van Wely, Marleen H., Cetinyurek-Yavuz, Aysun, Byrne, Robert A., van Royen, Niels, and van Geuns, Robert-Jan M.

Published
2024
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4. Rationale and design of the pullback pressure gradient (PPG) global registry

Author

Munhoz, Daniel, Collet, Carlos, Mizukami, Takuya, Yong, Andy, Leone, Antonio Maria, Eftekhari, Ashkan, Ko, Brian, da Costa, Bruno R., Berry, Colin, Collison, Damien, Perera, Divaka, Christiansen, Evald Høj, Rivero, Fernando, Zimmermann, Frederik M., Ando, Hirohiko, Matsuo, Hitoshi, Nakayama, Masafumi, Escaned, Javier, Sonck, Jeroen, Sakai, Koshiro, Adjedj, Julien, Desta, Liyew, van Nunen, Lokien X., West, Nick E.J., Fournier, Stephane, Storozhenko, Tatyana, Amano, Tetsuya, Engstrøm, Thomas, Johnson, Thomas, Shinke, Toshiro, Biscaglia, Simone, Fearon, William F., Ali, Ziad, De Bruyne, Bernard, and Johnson, Nils P.

Published
2023
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9. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlos, primary, Munhoz, Daniel, additional, Mizukami, Takuya, additional, Sonck, Jeroen, additional, Matsuo, Hitoshi, additional, Shinke, Toshiro, additional, Ando, Hirohiko, additional, Ko, Brian, additional, Biscaglia, Simone, additional, Rivero, Fernando, additional, Engstrøm, Thomas, additional, Arslani, Ketina, additional, Leone, Antonio Maria, additional, van Nunen, Lokien X., additional, Fearon, William F., additional, Christiansen, Evald Høj, additional, Fournier, Stephane, additional, Desta, Liyew, additional, Yong, Andy, additional, Adjej, Julien, additional, Escaned, Javier, additional, Nakayama, Masafumi, additional, Eftekhari, Ashkan, additional, Zimmermann, Frederik M., additional, Sakai, Koshiro, additional, Storozhenko, Tatyana, additional, da Costa, Bruno R., additional, Campo, Gianluca, additional, West, Nick E.J., additional, De Potter, Tom, additional, Heggermont, Ward, additional, Buytaert, Dimitri, additional, Bartunek, Jozef, additional, Berry, Colin, additional, Collison, Damien, additional, Johnson, Thomas, additional, Amano, Tetsuya, additional, Perera, Divaka, additional, Jeremias, Allen, additional, Ali, Ziad, additional, Pijls, Nico H.J., additional, De Bruyne, Bernard, additional, and Johnson, Nils P., additional

Published
2024
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11. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, and Leone, Antonio Maria (ORCID:0000-0002-1276-9883)

Abstract

Background: Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularisation and procedural outcomes. Methods: This prospective, investigator-initiated, single-arm, multicentre study enrolled patients with at least one epicardial lesion with an FFR ≤ 0.80 scheduled for PCI. Manual FFR pullbacks were employed to calculate PPG. The primary outcome of optimal revascularisation was defined as a post-PCI FFR ≥ 0.88. Results: 993 patients with 1044 vessels were included. The mean FFR was 0.68 ± 0.12, PPG 0.62 ± 0.17, and post-PCI FFR 0.87 ± 0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65, 95% CI 0.61-0.69, p<0.001) and demonstrated excellent predicted capacity for optimal revascularisation (AUC 0.82, 95% CI 0.79-0.84, p<0.001). Conversely, FFR alone did not predict revascularisation outcomes (AUC 0.54, 95% CI 0.50-0.57). PPG influenced treatment decisions in 14% of patients, redirecting them from PCI to alternative treatment modalities. Periprocedural myocardial infarction occurred more frequently in patients with low PPG (<0.62) compared to those with focal disease (OR 1.71, 95% CI: 1.00-2.97). Conclusions: Pathophysiological CAD patterns distinctly affect the safety and effectiveness of PCI. The PPG showed an excellent predictive capacity for optimal revascularisation and demonstrated added value compared to a FFR measurement.

Published
2024

12. Using Upper Arm Vein as Temporary Pacemaker Access Site: A Next Step in Minimizing the Invasiveness of Transcatheter Aortic Valve Replacement

Author

Rooijakkers, Maxim J. P., primary, Versteeg, Geert A. A., additional, van Wely, Marleen H., additional, Rodwell, Laura, additional, van Nunen, Lokien X., additional, van Geuns, Robert Jan, additional, van Garsse, Leen A. F. M., additional, Geuzebroek, Guillaume S. C., additional, Verkroost, Michel W. A., additional, Heijmen, Robin H., additional, and van Royen, Niels, additional

Published
2024
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18. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial

Author

van Nunen, Lokien X, Zimmermann, Frederik M, Tonino, Pim A L, Barbato, Emanuele, Baumbach, Andreas, Engstrøm, Thomas, Klauss, Volker, MacCarthy, Philip A, Manoharan, Ganesh, Oldroyd, Keith G, Ver Lee, Peter N, van't Veer, Marcel, Fearon, William F, De Bruyne, Bernard, and Pijls, Nico H J

Published
2015
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21. Angiographic predictors of aberrant circumflex artery during cardiac catheterization

Author

Triantafyllis, Andreas S., primary, van Nunen, Lokien X., additional, Lesizza, Pierluizi, additional, Pagourelias, Efstathios D., additional, Kalogeris, Aimilianos, additional, Bouwmeester, Sjoerd, additional, Tsinivizov, Pavlos, additional, Kontogiannis, Nestoras, additional, Giannakopoulos, Andreas, additional, Poulimenos, Leonidas E., additional, Bennett, Johan, additional, Teeuwen, Koen, additional, Kyfnidis, Konstantinos, additional, Desmet, Walter, additional, Tonino, Pim A. L., additional, and McCutcheon, Keir, additional

Published
2022
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22. Accuracy and Potential Benefit of Ultraselective Invasive Coronary Angiography Guided by Computed Tomographic Coronary Angiography

Author

van Beek, Konrad A.J., de Lepper, Anouk G.W., van't Veer, Marcel, Bouwmeester, Sjoerd, Otterspoor, Luuk C., Tonino, Pim A.L., Lammers, Jeroen, Winkens, Mark, van Nunen, Lokien X., Signal Processing Systems, Eindhoven MedTech Innovation Center, and Cardiovascular Biomechanics

Subjects
radiation exposure, computed tomographic coronary angiography, coronary angiography, coronary artery disease
Abstract

OBJECTIVES: It is unknown whether computed tomographic coronary angiography (CTCA) can be used to perform ultraselective invasive coronary angiography (ICA) by only visualizing the abnormal coronary artery on CTCA and defer visualization of the normal contralateral coronary artery. This study assessed the accuracy of CTCA in patients with coronary artery disease (CAD) on CTCA limited to either the left (LCA) or right coronary artery (RCA) in predicting a contralateral coronary artery without abnormalities on CTCA determined to be normal by ICA. METHODS: This retrospective analysis included patients with CAD limited to the LCA or RCA on CTCA. Primary endpoint was the accuracy of CTCA to predict a contralateral coronary artery without abnormalities on CTCA to be normal by ICA. Secondary endpoints were potential reductions in procedure time and radiation exposure if an ultraselective ICA approach would be used compared to standard ICA. RESULTS: In total, 202 patients were included. CTCA was correct in predicting a normal contralateral coronary artery in 201 of the 202 patients (99.5%). Deferring ICA of the normal contralateral coronary artery on CTCA resulted in a potential reduction in procedure time and dose area product of 4.22 ± 2.67 minutes (61 ± 16% reduction) and 1501 ± 1304 mGy•cm² (29 ± 13% reduction). CONCLUSIONS: In this retrospective study, CTCA was extremely accurate in predicting a normal contralateral coronary artery in patients with LCA- or RCA-limited CAD on CTCA. A potential CTCA-guided ultraselective ICA approach was feasible and would have led to a considerable decrease in procedure time and radiation exposure.

Published
2022

24. Upper- vs Lower-Extremity Secondary Access During Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial.

Author

Versteeg, Geert A. A., Rooijakkers, Maxim J. P., Hemelrijk, Kimberley I., Vlaar, Pieter J., Overduin, Daniël C., van Wely, Marleen H., Aarts, Hugo M., van Ginkel, Dirk-Jan, van Nunen, Lokien X., van Geuns, Robert Jan, van Garsse, Leen A. F. M., Geuzebroek, Guillaume S. C., Verkroost, Michel W. A., Cetinyurek-Yavuz, Aysun, Heijmen, Robin H., ten Berg, Jurrien M., Tonino, Pim A. L., Delewi, Ronak, and van Royen, Niels

Published
2024
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25. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial

Author

Zimmermann, Frederik M., Ferrara, Angela, Johnson, Nils P., van Nunen, Lokien X., Escaned, Javier, Albertsson, Per, Erbel, Raimund, Legrand, Victor, Gwon, Hyeong-Cheol, Remkes, Wouter S., Stella, Pieter R., van Schaardenburgh, Pepijn, Bech, G. Jan Willem, De Bruyne, Bernard, and Pijls, Nico H.J.

Published
2015
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31. Intra-aortic balloon pump counterpulsation in extensive myocardial infarction with persistent ischemia: the SEMPER FI pilot study

Author

van Nunen, Lokien X., van ’t Veer, Marcel, Zimmermann, Frederik M., Wijnbergen, Inge, Brueren, Guus R.G., Tonino, Pim A.L., Aarnoudse, Wilbert A., Pijls, Nico H.J., van Nunen, Lokien X., van ’t Veer, Marcel, Zimmermann, Frederik M., Wijnbergen, Inge, Brueren, Guus R.G., Tonino, Pim A.L., Aarnoudse, Wilbert A., and Pijls, Nico H.J.

Abstract

Objectives: This study aimed to prospectively investigate intra-aortic balloon pump counterpulsation (IABP) support in large myocardial infarction complicated by persistent ischemia after primary percutaneous coronary intervention (PCI). Background: Use of IABP is suggested to be effective by increasing diastolic aortic pressure, thereby improving coronary blood flow. This can only be expected with exhausted coronary autoregulation, typical in acute myocardial infarction complicated by persistent ischemia. In this situation, augmented diastolic pressure is expected to increase myocardial oxygenation. Methods: One hundred patients with large STEMI complicated by persistent ischemia after primary PCI were randomized to treatment with or without IABP therapy on top of standard care. IABP support was initiated following primary PCI, immediately after inclusion. Primary end point was all-cause mortality, need for (additional) mechanical hemodynamic support, or readmission for heart failure within 6 months. Results: Mean age was 63 ± 10 years, 76% were male. Mean systolic and diastolic blood pressure were 120 ± 25 mmHg and 73 ± 17 mmHg. Mean heart rate was 75 ± 18 mmHg. Before PCI, mean summed ST-deviation was 21 ± 8 mm with only minimal ST-resolution after PCI. One patient in the IABP group reached the primary end point versus four patients in the control group (2% vs. 8%; p = 0.16). After primary PCI, resolution of ST-deviation was significantly more pronounced in the IABP group (73 ± 17%) compared to the control group (56 ± 26%; p < 0.01). Conclusions: In this pilot study, in patients with large STEMI and persistent ischemia after primary PCI, use of IABP showed a nonsignificant decrease in mortality, necessity for (additional) mechanical hemodynamic support or readmission for heart failure at 6 months, and resulted in more rapid ST-resolution.

Published
2020

37. Comparison of different diastolic resting indexes to iFR: are they all equal?

Author

Van't Veer, Marcel, Pijls, Nico H.J., Hennigan, Barry, Watkins, Stuart, Ali, Ziad A., De Bruyne, Bernard, Zimmermann, Frederik M., van Nunen, Lokien X., Barbato, Emanuele, Berry, Colin, Oldroyd, Keith G., Van't Veer, Marcel, Pijls, Nico H J, Hennigan, Barry, Watkins, Stuart, Ali, Ziad A, De Bruyne, Bernard, Zimmermann, Frederik M, van Nunen, Lokien X, Barbato, Emanuele, Berry, Colin, and Oldroyd, Keith G

Subjects
coronary physiology, iFR, resting indexe, wave-free period, FFR, coronary pressure measurement
Abstract

Background: \ud Pressure measurement for the duration of the wave-free period (WFP) is considered essential for resting-state physiological assessment of coronary stenosis severity using the instantaneous wave-free ratio (iFR).\ud \ud Objectives: \ud The aim of this study was to compare other diastolic resting indexes to iFR.\ud \ud Methods: \ud In the population of the VERIFY2 (Pd/Pa vs iFR in an Unselected Population Referred for Invasive Angiography) study, iFR calculated by proprietary software (Volcano Harvest, Volcano Corporation, Rancho Cordova, California) was compared with the ratio of resting distal coronary pressure and aortic pressure during the complete duration of diastole (dPR), 25% to 75% of diastole (dPR25–75), and midpoint of diastole (dPRmid), along with Matlab calculated iFR (iFRmatlab) and iFR-like indexes shortening the length of the WFP by 50 and 100 ms (iFR−50ms and iFR−100ms), respectively. Mutual differences, Spearman correlations, area under the curve values from receiver-operating characteristic analyses, and diagnostic performance with respect to iFR and fractional flow reserve (FFR) were calculated for all indexes.\ud \ud Results: \ud Median iFR in 197 patients with 257 vessels was 0.91 with an interquartile range of 0.87 to 0.95. The mutual differences (± SD) with iFR were 0.006 ± 0.011 (dPR), 0.001 ± 0.007 (dPR25–75), 0.001 ± 0.008 (dPRmid), 0.005 ± 0.009 (iFRmatlab), 0.003 ± 0.008 (iFR−50ms), and 0.001 ± 0.009 (iFR−100ms). Correlations for all indexes with iFR were >0.99 (p < 0.001 for all). Area under the curve values for predicting iFR were >0.99 for all indexes as well. Diagnostic accuracy compared with FFR was 76% to 77% for all indexes including iFR.\ud \ud Conclusions: \ud All diastolic resting indexes tested were identical to iFR, both numerically and with respect to their agreement with FFR. A numerically equal value to iFR can be determined without restriction to the WFP. Cutoff values, guidelines, and clinical recommendations for iFR can therefore be extended to these other indexes. (Pd/Pa vs iFR in an Unselected Population Referred for Invasive Angiography [VERIFY2]; NCT02377310).

Published
2017

41. Results of systematic patient outcome monitoring: Does post-dilatation during angiography-guided percutaneous coronary intervention improve clinical outcomes?

Author

Slingerland, Stacey R., van Beek, Konrad A.J., Schulz, Daniela N., van Steenbergen, Gijs J., Brouwer, Tim, Stoel, Martin, Vlaar, Pieter-Jan, Tonino, Pim A., Dekker, Lukas, van Nunen, Lokien X., Teeuwen, Koen, and van Veghel, Dennis

Abstract

This study evaluates clinical outcomes after implementing a liberal post-dilatation strategy during PCI.

Published
2024
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46. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial

Author

van Nunen, Lokien, Zimmermann, F.M. (Frederik), Tonino, P.A.L. (Pim), Barbato, E. (Emanuele), Baumbach, A. (Andreas), Engstrøm, T. (Thomas), Klauss, V. (Volker), MacCarthy, P.A. (Philip), Manoharan, G. (Ganesh), Oldroyd, Keith G., Ver Lee, P.N. (Peter), van 't Veer, Marcel, Fearon, W.F. (William), Bruyne, de, B. (Bernard), Pijls, Nico, van Nunen, Lokien, Zimmermann, F.M. (Frederik), Tonino, P.A.L. (Pim), Barbato, E. (Emanuele), Baumbach, A. (Andreas), Engstrøm, T. (Thomas), Klauss, V. (Volker), MacCarthy, P.A. (Philip), Manoharan, G. (Ganesh), Oldroyd, Keith G., Ver Lee, P.N. (Peter), van 't Veer, Marcel, Fearon, W.F. (William), Bruyne, de, B. (Bernard), and Pijls, Nico

Abstract

Summary Background In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up. Methods The FAME study was a multicentre trial done in Belgium, Denmark, Germany, the Netherlands, Sweden, the UK, and the USA. Patients (aged ???18 years) with multivessel coronary artery disease were randomly assigned to undergo angiography-guided PCI or FFR-guided PCI. Before randomisation, stenoses requiring PCI were identified on the angiogram. Patients allocated to angiography-guided PCI had revascularisation of all identified stenoses. Patients allocated to FFR-guided PCI had FFR measurements of all stenotic arteries and PCI was done only if FFR was 0??80 or less. No one was masked to treatment assignment. The primary endpoint was major adverse cardiac events at 1 year, and the data for the 5-year follow-up are reported here. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00267774. Findings After 5 years, major adverse cardiac events occurred in 31% of patients (154 of 496) in the angiography-guided group versus 28% (143 of 509 patients) in the FFR-guided group (relative risk 0??91, 95% CI 0??75-1??10; p=0??31). The number of stents placed per patient was significantly higher in the angiography-guided group than in the FFR-guided group (mean 2??7 [SD 1??2] vs 1??9 [1??3], p

Published
2015

47. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial

Author

Cardiologie, Circulatory Health, Zimmermann, Frederik M., Ferrara, Angela, Johnson, Nils P., Van Nunen, Lokien X., Escaned, Javier, Albertsson, Per, Erbel, Raimund, Legrand, Victor, Gwon, Hyeong Cheol, Remkes, Wouter S., Stella, Pieter R., Van Schaardenburgh, Pepijn, Jan Willem Bech, G., De Bruyne, Bernard, Pijls, Nico H J, Cardiologie, Circulatory Health, Zimmermann, Frederik M., Ferrara, Angela, Johnson, Nils P., Van Nunen, Lokien X., Escaned, Javier, Albertsson, Per, Erbel, Raimund, Legrand, Victor, Gwon, Hyeong Cheol, Remkes, Wouter S., Stella, Pieter R., Van Schaardenburgh, Pepijn, Jan Willem Bech, G., De Bruyne, Bernard, and Pijls, Nico H J

Published
2015

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