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129 results on '"van Melick, H."'

9. Is cribriform pattern in prostate biopsy a risk factor for metastatic disease on 68Ga-PSMA-11 PET/CT?

Author

Heetman, J. G., Versteeg, R., Wever, L., Paulino Pereira, L. J., Soeterik, T. F. W., Lavalaye, J., de Bruin, P. C., van den Bergh, R. C. N., and van Melick, H. H. E.

Subjects
DISEASE risk factors, PROSTATE biopsy, PROSTATE cancer, COMPUTED tomography
Abstract

Introduction: Cribriform growth pattern (CP) in prostate cancer (PCa) has been associated with different unfavourable oncological outcomes. This study addresses if CP in prostate biopsies is an independent risk factor for metastatic disease on PSMA PET/CT. Methods: Treatment-naive patients with ISUP GG ≥ 2 staged with 68Ga-PSMA-11 PET/CT diagnosed from 2020 to 2021 were retrospectively enrolled. To test if CP in biopsies was an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT, regression analyses were performed. Secondary analyses were performed in different subgroups. Results: A total of 401 patients were included. CP was reported in 252 (63%) patients. CP in biopsies was not an independent risk factor for metastatic disease on the 68Ga-PSMA PET/CT (p = 0.14). ISUP grade group (GG) 4 (p = 0.006), GG 5 (p = 0.003), higher PSA level groups per 10 ng/ml until > 50 (p-value between 0.02 and > 0.001) and clinical EPE (p > 0.001) were all independent risk factors. In the subgroups with GG 2 (n = 99), GG 3 (n = 110), intermediate-risk group (n = 129) or the high-risk group (n = 272), CP in biopsies was also not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT. If the EAU guideline recommendation for performing metastatic screening was applied as threshold for PSMA PET/CT imaging, in 9(2%) patients, metastatic disease was missed, and 18% fewer PSMA PET/CT would have been performed. Conclusion: This retrospective study found that CP in biopsies was not an independent risk factor for metastatic disease on 68Ga-PSMA PET/CT. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Circulating tumour cells to drive the use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer

Author

Beije, N., de Kruijff, I. E., de Jong, J. J., Klaver, S. O., de Vries, P., Jacobs, R. A.L., Somford, D. M., te Slaa, E., van der Heijden, A. G., Alfred Witjes, J., Fossion, L. M.C.L., Boevé, E. R., van der Hoeven, J., van Melick, H. H.E., Wijburg, C. J., Bickerstaffe, H., Martens, J. W.M., de Wit, R., Kraan, J., Sleijfer, S., Boormans, J. L., Beije, N., de Kruijff, I. E., de Jong, J. J., Klaver, S. O., de Vries, P., Jacobs, R. A.L., Somford, D. M., te Slaa, E., van der Heijden, A. G., Alfred Witjes, J., Fossion, L. M.C.L., Boevé, E. R., van der Hoeven, J., van Melick, H. H.E., Wijburg, C. J., Bickerstaffe, H., Martens, J. W.M., de Wit, R., Kraan, J., Sleijfer, S., and Boormans, J. L.

Abstract

Background: Guidelines recommend neoadjuvant chemotherapy (NAC) for the treatment of nonmetastatic muscle-invasive bladder cancer (MIBC). NAC is, however, underutilized in practice because of its associated limited overall survival (OS) benefit and significant treatment-related toxicity. We hypothesized that the absence of circulating tumour cells (CTCs) identifies MIBC patients with such a favourable prognosis that NAC may be withheld. Patients and methods: The CirGuidance study was an open-label, multicentre trial that included patients with clinical stage T2-T4aN0-N1M0 MIBC, scheduled for radical cystectomy. CTC-negative patients (no CTCs detectable using the CELLSEARCH system) underwent radical surgery without NAC; CTC-positive patients (≥1 detectable CTCs) were advised to receive NAC, followed by radical surgery. The primary endpoint was the 2-year OS in the CTC-negative group with a prespecified criterion for trial success of ≥75% (95% confidence interval (CI) ±5%). Results: A total of 273 patients were enrolled. Median age was 69 years; median follow-up was 36 months. The primary endpoint of 2-year OS in the CTC-negative group was 69.5% (N = 203; 95% CI 62.6%-75.5%). Two-year OS was 58.2% in the CTC-positive group (N = 70; 95% CI 45.5%-68.9%). CTC-positive patients had a higher rate of cancer-related mortality [hazard ratio (HR) 1.61, 95% CI 1.05-2.45, P = 0.03] and disease relapse (HR 1.87, 95% CI 1.28-2.73, P = 0.001) than CTC-negative patients. Explorative analyses suggested that CTC-positive patients who had received NAC (n = 22) survived longer than CTC-positive patients who had not (n = 48). Conclusion: The absence of CTCs in MIBC patients was associated with improved cancer-related mortality and a lower risk of disease relapse after cystectomy; however, their absence alone does not justify to withhold NAC. Exploratory analyses suggested that CTC-positive MIBC patients might derive more benefit from NAC. Trial registration: Netherlands Trial Register

Published
2022

11. Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer

Author

Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, MS Radiologie, MS Radiotherapie, MS Urologische Oncologie, Urologie Medisch volwassenen, Trialbureau Beeld, Klinische Fysica RT, Teunissen, F. R., Wortel, R. C., Wessels, F. J., Claes, A., van de Pol, S. M.G., Rasing, M. J.A., Meijer, R. P., van Melick, H. H.E., de Boer, J. C.J., Verkooijen, H. M., van der Voort van Zyp, J. R.N., Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, MS Radiologie, MS Radiotherapie, MS Urologische Oncologie, Urologie Medisch volwassenen, Trialbureau Beeld, Klinische Fysica RT, Teunissen, F. R., Wortel, R. C., Wessels, F. J., Claes, A., van de Pol, S. M.G., Rasing, M. J.A., Meijer, R. P., van Melick, H. H.E., de Boer, J. C.J., Verkooijen, H. M., and van der Voort van Zyp, J. R.N.

Published
2022

14. Interrater agreement in contouring the neurovascular bundle and internal pudendal artery for MRgRT

Author

Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, MS Radiologie, MS Radiotherapie, Klinische Fysica RT, MS Urologische Oncologie, Trialbureau Beeld, Teunissen, F., Wortel, R., Wessels, F., van de Pol, S., Rasing, M., Claes, A., de Boer, J., Meijer, R., van Melick, H., Verkooijen, H., van Zyp, J. van der Voort, Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, MS Radiologie, MS Radiotherapie, Klinische Fysica RT, MS Urologische Oncologie, Trialbureau Beeld, Teunissen, F., Wortel, R., Wessels, F., van de Pol, S., Rasing, M., Claes, A., de Boer, J., Meijer, R., van Melick, H., Verkooijen, H., and van Zyp, J. van der Voort

Published
2021

15. Feasibility of neurovascular sparing MR-guided adaptive radiotherapy for prostate cancer

Author

Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, Klinische Fysica RT, MS Urologische Oncologie, Trialbureau Beeld, MS Radiotherapie, Teunissen, F., Wortel, R., Hes, J., Willigenburg, T., de Boer, J., Meijer, R., van Melick, H., Verkooijen, H., van Zyp, J. van der Voort, Onderzoek Radiotherapie, Cancer, Urologie Onderzoek, Klinische Fysica RT, MS Urologische Oncologie, Trialbureau Beeld, MS Radiotherapie, Teunissen, F., Wortel, R., Hes, J., Willigenburg, T., de Boer, J., Meijer, R., van Melick, H., Verkooijen, H., and van Zyp, J. van der Voort

Published
2021

17. New national and regional bryophyte records, 66

Author

Ellis, L. T., primary, Alataş, M., additional, Aleffi, M., additional, Álvaro Alba, W. R., additional, Becerra Infante, D. A., additional, Cárdenas Espinosa, K. A., additional, Aziz, Md N., additional, Bakalin, V. A., additional, Bergamo Decarli, G., additional, Boiko, M., additional, Zagorodniuk, N., additional, Boiko, L. M., additional, Borovichev, E. A., additional, Brusa, G., additional, Cano, M. J., additional, Jiménez, J. A., additional, Choi, S. S., additional, Draper, I., additional, Lara, F., additional, Dunlin, M. V., additional, Enroth, J., additional, Ezer, T., additional, Fedosov, V. E., additional, Fuertes, E., additional, Garilleti, R., additional, Albertos, B., additional, Gradstein, S. R., additional, Graulich, A., additional, Hugonnot, V., additional, Hyun, C. W., additional, Kırmacı, M., additional, Filiz, F., additional, Çatak, U., additional, Konstantinova, N. A., additional, Savchenko, A. N., additional, Kropik, M., additional, Kučera, J., additional, Kürschner, H., additional, Yu. Kuzmina, E., additional, Liksakova, N. S., additional, Maity, D., additional, Martin, P., additional, McIntosh, T. T., additional, van Melick, H. M. H., additional, Moncada, B., additional, Németh, Cs., additional, O’Leary, S. V., additional, Peñaloza-Bojacá, G. F., additional, Maciel-Silva, S. A., additional, Poponessi, S., additional, Cogoni, A., additional, Porley, R. D., additional, Potemkin, A. D., additional, Puglisi, M., additional, Sciandrello, S., additional, Rawat, K. K., additional, Sahu, V., additional, Paul, R. R., additional, Ryan, M., additional, Saha, P., additional, Salas, D. S., additional, Segarra-Moragues, J. G., additional, Sguazzin, F., additional, Shafigullina, N. R., additional, Shevock, J. R., additional, Ștefănuţ, S., additional, Uygur, A., additional, Karaman Erkul, S., additional, Ursavaş, S., additional, Özen, A., additional, Zechmeister, H. G., additional, and Zander, R. H., additional

Published
2021
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18. Treatment of High-grade Non–muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial “NIMBUS”

Author

MS Urologische Oncologie, Cancer, Urologie Medisch volwassenen, Grimm, Marc Oliver, van der Heijden, A. G., Colombel, Marc, Muilwijk, Tim, Martínez-Piñeiro, Luis, Babjuk, Marko M., Türkeri, Levent N., Palou, Joan, Patel, Anup, Bjartell, Anders S., Caris, Christien, Schipper, Raymond G., Witjes, Wim P.J., Horstmann, Jörg, Machtens, Stefan, Mumperow, Eberhard, Ghazal, Andreas Al, Pulte, Thomas, Stephan-Odenthal, Michael, Gakis, Georgios, Kramer, Mario, Zaak, Dirk, Schmitz-Dräger, Bernd, Schreier, Holger, Lehmann, Jan, Werner, Torsten, Klier, Jörg, Marin, Jan, Rulf, Wolfgang, Hellmis, Eva, Schneider, Andreas, Spiegelhalder, Wirth, Manfred, Klotz, Theodor, Suttmann, Henrik, Siebels, Michael, Rodemer, Gerd, Rudolph, Robert, Zillmann, Roger, de Bruin, M., Bos, S., van Moorselaar, R., de Reijke, T., Boormans, J., Wijsman, B., van Melick, H. H.E., van Boven, E., Meijer, R. P., Vergunst, H., te Slaa, E., Leliveld-Kors, A. M., Ruffion, Alain, Pfister, Christian, Roupret, Morgan, Irani, Jacques, Stoica, Gabriel, Van Bruwaene, Siska, Ameye, Filip, Arentsen, Harm, Joniau, Steven, Beardo, Pastora, MS Urologische Oncologie, Cancer, Urologie Medisch volwassenen, Grimm, Marc Oliver, van der Heijden, A. G., Colombel, Marc, Muilwijk, Tim, Martínez-Piñeiro, Luis, Babjuk, Marko M., Türkeri, Levent N., Palou, Joan, Patel, Anup, Bjartell, Anders S., Caris, Christien, Schipper, Raymond G., Witjes, Wim P.J., Horstmann, Jörg, Machtens, Stefan, Mumperow, Eberhard, Ghazal, Andreas Al, Pulte, Thomas, Stephan-Odenthal, Michael, Gakis, Georgios, Kramer, Mario, Zaak, Dirk, Schmitz-Dräger, Bernd, Schreier, Holger, Lehmann, Jan, Werner, Torsten, Klier, Jörg, Marin, Jan, Rulf, Wolfgang, Hellmis, Eva, Schneider, Andreas, Spiegelhalder, Wirth, Manfred, Klotz, Theodor, Suttmann, Henrik, Siebels, Michael, Rodemer, Gerd, Rudolph, Robert, Zillmann, Roger, de Bruin, M., Bos, S., van Moorselaar, R., de Reijke, T., Boormans, J., Wijsman, B., van Melick, H. H.E., van Boven, E., Meijer, R. P., Vergunst, H., te Slaa, E., Leliveld-Kors, A. M., Ruffion, Alain, Pfister, Christian, Roupret, Morgan, Irani, Jacques, Stoica, Gabriel, Van Bruwaene, Siska, Ameye, Filip, Arentsen, Harm, Joniau, Steven, and Beardo, Pastora

Published
2020

19. Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer

Author

Researchgr. Nucleaire Geneeskunde, MS Urologische Oncologie, Urologie Medisch volwassenen, Cancer, CMM Groep Coffer, Child Health, Regenerative Medicine and Stem Cells, MS Radiologie, Unit Opleiding Aios, van Kalmthout, L W M, van Melick, H H E, Lavalaye, J, Meijer, R P, Kooistra, A, de Klerk, J M H, Braat, A J A T, Kaldeway, H P, de Keizer, B, Lam, M G E H, Researchgr. Nucleaire Geneeskunde, MS Urologische Oncologie, Urologie Medisch volwassenen, Cancer, CMM Groep Coffer, Child Health, Regenerative Medicine and Stem Cells, MS Radiologie, Unit Opleiding Aios, van Kalmthout, L W M, van Melick, H H E, Lavalaye, J, Meijer, R P, Kooistra, A, de Klerk, J M H, Braat, A J A T, Kaldeway, H P, de Keizer, B, and Lam, M G E H

Published
2020

23. Adjuvant recMAGE-A3 Immunotherapy After Cystectomy for Muscle-invasive Bladder Cancer: Lessons Learned from the Phase 2 MAGNOLIA Clinical Trial

Author

Mulders, Peter F. A., Martinez-Pineiro, Luis, Heidenreich, Axel, Babjuk, Marko, Colombel, Marc, Colombo, Renzo, Radziszewski, Piotr, Korneyev, Igor, Surcel, Cristian, Yakovlevi, Pavel, Witjes, J. Alfred, Caris, Christien, Schipper, Raymond, Witjes, Wim P. J., Villers, A., Malavaud, B., Rouboud, G., Grimm, M. O., Retz, M., Wagenlehner, F., Stenzl, A., Olbert, P., Niegisch, G., Hakenberg, O., Goebell, P., Wirth, M., Bolenz, C., Tubaro, A., Selli, C., Porena, M., Kerst, M., van Melick, H., Antoniewicz, A., Chlosta, P., Palou, J., Ponce Diaz-Reixa, J., Alonso Dorrego, J. M., Llorente, C., Fernandez-Gomez, J., Alvarez Maestro, M., Alvarez-Ossorio, J. L., Sanchez Chapado, M., Ribal, M., Guix, M., Bellmunt, J., Villacampa, F., Schraml, J., Zachoval, R., Sinescu, I, Stoica, L., Sakalo, V, Matveev, V, Alekseev, B., Komyakov, B., Van den Steen, Peter, Mulders, Peter F. A., Martinez-Pineiro, Luis, Heidenreich, Axel, Babjuk, Marko, Colombel, Marc, Colombo, Renzo, Radziszewski, Piotr, Korneyev, Igor, Surcel, Cristian, Yakovlevi, Pavel, Witjes, J. Alfred, Caris, Christien, Schipper, Raymond, Witjes, Wim P. J., Villers, A., Malavaud, B., Rouboud, G., Grimm, M. O., Retz, M., Wagenlehner, F., Stenzl, A., Olbert, P., Niegisch, G., Hakenberg, O., Goebell, P., Wirth, M., Bolenz, C., Tubaro, A., Selli, C., Porena, M., Kerst, M., van Melick, H., Antoniewicz, A., Chlosta, P., Palou, J., Ponce Diaz-Reixa, J., Alonso Dorrego, J. M., Llorente, C., Fernandez-Gomez, J., Alvarez Maestro, M., Alvarez-Ossorio, J. L., Sanchez Chapado, M., Ribal, M., Guix, M., Bellmunt, J., Villacampa, F., Schraml, J., Zachoval, R., Sinescu, I, Stoica, L., Sakalo, V, Matveev, V, Alekseev, B., Komyakov, B., and Van den Steen, Peter

Published
2019

24. De FUTURE trial; een multicenter RCT naar MRI-geleide prostaatbiopten: Vergelijking van drie technieken van target biopten en vergelijking met systematische biopten

Author

MS Urologische Oncologie, Wegelin, O., Exterkate, L., Barentsz, J. O., van der Leest, M. G., Kelder, J. C., Kummer, J. A., Vreuls, W., de Bruin, P. C., de Vocht, T. F., Nuininga, J. E., Bosch, J. L.H.R., Somford, D. M., van Melick, H. H.E., MS Urologische Oncologie, Wegelin, O., Exterkate, L., Barentsz, J. O., van der Leest, M. G., Kelder, J. C., Kummer, J. A., Vreuls, W., de Bruin, P. C., de Vocht, T. F., Nuininga, J. E., Bosch, J. L.H.R., Somford, D. M., and van Melick, H. H.E.

Published
2019

26. New national and regional bryophyte records, 58

Author

Ellis, L. T., primary, Afonina, O. M., additional, Doroshina, G. Ya., additional, Agudelo, C., additional, Andriamiarisoa, R. L., additional, Asthana, A. K., additional, Gupta, D., additional, Gupta, R., additional, Rawat, K. K., additional, Sahu, V., additional, Aymerich, P., additional, Bednarek-Ochyra, H., additional, Brugués, M., additional, Ruiz, E., additional, Sáez, L., additional, Callaghan, D. A., additional, Caspari, S., additional, Drapela, P., additional, Dugarova, O. D., additional, Tubanova, D. Ya., additional, Erzberger, P., additional, Flores, J. R., additional, Suárez, G. M., additional, Fedosov, V. E., additional, Gospodinov, G., additional, Gradstein, S. R., additional, Reeb, C., additional, Jukonienė, I., additional, Subkaitė, M., additional, Kučera, J., additional, Lee, G. E., additional, Lombo, Y. J., additional, Suarez, K. Y., additional, Lebouvier, M., additional, Majumdar, S., additional, Müller, F., additional, Nagy, J., additional, Norhazrina, N., additional, Papp, B., additional, Plášek, V., additional, Pócs, T., additional, Puglisi, M., additional, Schäfer-Verwimp, A., additional, Shirzadian, S., additional, Singh, D. K., additional, Ştefănuţ, S., additional, Torzewski, K., additional, van Melick, H., additional, Wolski, G. J., additional, and Zander, R. H., additional

Published
2019
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29. Reduce bladder cancer recurrence in patients treated for upper urinary tract urothelial carcinoma: The REBACARE-trial

Author

UMC Utrecht, Cancer, Urologie Medisch volwassenen, MS Urologische Oncologie, van Doeveren, T., van Leeuwen, P. J., Aben, K. K.H., van der Aa, M., Barendrecht, M., Boevé, E. R., Cornel, E. B., van der Heijden, A. G., Hendricksen, K., Hirdes, W., Kooistra, A., Kroon, B. K., Leliveld, A. M., Meijer, R. P., van Melick, H., Merks, B., de Reijke, T. M., de Vries, P., Wymenga, L. F.A., Wijsman, B., Boormans, J. L., UMC Utrecht, Cancer, Urologie Medisch volwassenen, MS Urologische Oncologie, van Doeveren, T., van Leeuwen, P. J., Aben, K. K.H., van der Aa, M., Barendrecht, M., Boevé, E. R., Cornel, E. B., van der Heijden, A. G., Hendricksen, K., Hirdes, W., Kooistra, A., Kroon, B. K., Leliveld, A. M., Meijer, R. P., van Melick, H., Merks, B., de Reijke, T. M., de Vries, P., Wymenga, L. F.A., Wijsman, B., and Boormans, J. L.

Published
2018

30. Effect of a decision aid for lower urinary tract symptoms due to benign prostatic hyperplasia on informed and value congruent decision making: A prospective study with a historical control group

Author

Van Der Wijden, F., primary, De Angst, I., additional, Cuypers, M., additional, De Vries, M., additional, Lamers, R., additional, Van Melick, H., additional, De Beij, J., additional, Oerlemans, D., additional, Van De Beek, C., additional, and Kil, P., additional

Published
2018
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34. Surgical safety of immediate versus deferred cytoreductive nephrectomy (CN) in patients with synchronous metastatic renal cell carcinoma (mRCC) receiving sunitinib. Data from the EORTC randomized trial 30073 SURTIME

Author

Bex, A., primary, Mulders, P., additional, Jewett, M., additional, Wagstaff, J., additional, Van Velthoven, R., additional, Laguna, P., additional, Wood, L., additional, Van Melick, H., additional, Soetekouw, P., additional, Lattouf, J., additional, Powles, T., additional, De Jong, I., additional, Rottey, S., additional, Tombal, B., additional, Marreaud, S., additional, Collette, S., additional, Collette, L., additional, and Haanen, J., additional

Published
2018
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49. New national and regional bryophyte records, 40. Bryum calophyllum R. Br

Author

Ellis, L. T., Aleffi, Michele, Asthana, A. K., Srivastava, A., Bakalin, V. A., Batan, N., Özdemir, T., Bednarek Ochyra, H., Borovichev, E. A., Brugués, M., Cano, M. J., Choi, S. S., De Beer, D., Eckstein, J., Erzberger, P., Fedosov, V. E., Ganeva, A., Natcheva, R., Garcia, C. A., Sérgio, C., Garilleti, R., Albertos, B., Puche, F., Gücel, S., Higuchi, M., Hugonnot, V., Hylander, K., Kırmacı, M., Aslan, G., Koponen, T., Lara, F., Mazimpaka, V., van Melick, H., Müller, F., Özenoglu Kiremit, H., Papp, B., Szurdoki, E., Plášek, V., Čihal, L., van der Pluijm, A., Poponessi, S., Mariotti, M. G., Reyniers, J., Sabovljević, M. S., Sawicki, J., Smith, V. R., Stebel, A., Ştefănuţ, S., Sun, B. Y., Váňa, J., and Venanzoni, R.

Published
2014

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