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8. A Randomized Phase II Study Comparing Two Schedules of the 21-Day Regimen of Gemcitabine and Carboplatin in Advanced Non-Small Cell Lung Cancer

Author

Surmont, VFM, Aerts, Joachim, Klaveren, RJ, Tournoy, K, Tan, KY, Vernhout, René, Schmitz, Paul, Legrand, C, Hoogsteden, Henk, van Meerbeeck, JPAM (Jan), Surmont, VFM, Aerts, Joachim, Klaveren, RJ, Tournoy, K, Tan, KY, Vernhout, René, Schmitz, Paul, Legrand, C, Hoogsteden, Henk, and van Meerbeeck, JPAM (Jan)

Abstract

Purpose: Carboplatin area under the curve (AUC) 5 ml/min on day 1 with gemcitabine 1,250 mg/m(2) on day 1 and day 8 is a widely used regimen in advanced non-small cell lung cancer. Grade 3-4 thrombocytopenia and neutropenia are frequent. The aim of this study is to investigate whether toxicity of gemcitabine/carboplatin could be reduced by administering carboplatin on day 8 instead of day 1 without a decrease in response rate (RR). Methods: Patients received gemcitabine 1,250 mg/m(2) on days 1 and 8, carboplatin AUC 5 on day 1 (arm A) or day 8 (arm B). Drugs were administered over a 21-day cycle. Toxicity and RR were evaluated weekly and every second cycle, respectively. Results: 71 patients were enrolled into the study. We found 79% (95% CI 61-91%) grade 3-4 toxicity (neutropenia and thrombocytopenia) in arm A and 50% (95% CI 32-68%) in arm B; 66% grade 3-4 thrombocytopenia in arm A and 26% in arm B. We observed 30% grade 4 hematological toxicity in arm A and 3% in arm B. In arm A an overall RR of 20% (95% CI 7.7-38.6%) was seen, and 18.2% (95% CI 7-35.5%) in arm B. Conclusions: Although the study was prematurely closed, the current data are of interest. The schedule with carboplatin on day 8 is associated with substantially lower grade 3-4 neutropenia and thrombocytopenia with comparable dose intensity and RR. Copyright (C) 2010 S. Karger AG, Basel

Published
2010

10. Longafwijkingen door asbest

Author

Hoogsteden, Henk, van Meerbeeck, JPAM (Jan), Demedts, M., Dijkman, J.H., Hilvering, C., Postma, D.S., and Pulmonary Medicine

Published
1999

11. De pleura

Author

Burgers, JA (Jacobus), van Meerbeeck, JPAM (Jan), Postmus, PE, Hoogsteden, H.C., Dekhuijzen, P.N.R., Joos, G.F., Postmus, P.E., and Pulmonary Medicine

Published
1999

12. Epidemiologie van longtumoren

Author

van Meerbeeck, JPAM (Jan), Demedts, M., Dijkman, J.H., Hilvering, C., Postma, D.S., and Pulmonary Medicine

Published
1999

14. Nieuwvormingen in de long

Author

van Meerbeeck, JPAM (Jan), Hoogsteden, Henk, Postmus, PE, Hoogsteden, H.C., Dekhuijzen, P.N.R., Joos, G.F., Postmus, P.E., and Pulmonary Medicine

Published
1999

15. Pleurale tumoren

Author

van Meerbeeck, JPAM (Jan), Kwast, Theodorus, Hoogsteden, Henk, Demedts, M., Dijkman, J.H., Hilvering, C., Postma, D.S., and Pulmonary Medicine

Published
1999

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